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  • Species Specificity  (23)
  • Cell Line  (22)
  • American Association for the Advancement of Science (AAAS)  (43)
  • Uppsala
  • 2010-2014
  • 1980-1984  (43)
  • 1981  (43)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (43)
  • Uppsala
Years
  • 2010-2014
  • 1980-1984  (43)
Year
  • 1
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    Similar amino acid sequences: chance or common ancestry? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-09
    Description: The systemic comparison of every newly determined amino acid sequence with all other known sequences may allow a complete reconstruction of the evolutionary events leading to contemporary proteins. But sometimes the surviving similarities are so vague that even computer-based sequence comparisons procedures are unable to validate relationships. In other cases similar sequences may appear in totally alien proteins as a result of mere chance or, occasionally, by the convergent evolution of sequences with special properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doolittle, R F -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):149-59.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280687" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; Animals ; *Biological Evolution ; Carrier Proteins/genetics ; Humans ; Proteins/classification/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Insulin as a potent, specific growth factor in a rat hepatoma cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnani, J L -- Brockhaus, M -- Smith, D F -- Ginsburg, V -- Blaszczyk, M -- Mitchell, K F -- Steplewski, Z -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):55-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209516" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Antibodies, Neoplasm/*immunology ; Antibody Specificity ; Antigens, Neoplasm/*immunology/isolation & purification ; Cell Line ; Chromatography, Thin Layer ; Colonic Neoplasms/*immunology ; Gangliosides/*immunology/isolation & purification ; Humans ; Melanoma/immunology ; Neuraminidase/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    The complement system of the nurse shark: hemolytic and comparative characteristics (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: The complement system of the nurse shark was investigated. Six functionally pure components were isolated from a single serum sample. Sequential reactions of the components with sensitized sheep erythrocytes resulted in membrane lesions indistinguishable from the "holes" caused by guinea pig complement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, J A -- Festa, E -- Smith, D S -- Cayer, M -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):566-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Complement System Proteins/*physiology ; Erythrocyte Membrane/immunology ; Hemolysis ; Sharks/*immunology ; Sheep ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Human lupus inclusions and interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: Raji cells, a human B lymphoblastoid cell line of Burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of Raji cells whose DNA thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. Ultracentrifugation of this medium in excess of that required to remove Epstein-Barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase destroyed the activity. These results demonstrate the presence of a protein that is secreted from bromodeoxyuridine-substituted Raji cells and is capable of inducing nonbromodeoxyuridine-substituted cells to form lupus inclusions. Interferon (100 units per milliliter) was found in the conditioned medium. Inclusions also formed in Raji cells grown in fresh medium supplemented with human leukocyte or fibroblast interferon (100 units per milliliter).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, S A -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):772-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6166984" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/*metabolism ; Burkitt Lymphoma ; Cell Line ; Culture Media ; Cytoplasmic Granules/ultrastructure ; DNA Replication ; Humans ; Interferons/*biosynthesis ; Lupus Erythematosus, Systemic/*pathology
    Print ISSN: 0036-8075
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  • 9
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Elastic arteries in invertebrates: mechanics of the octopus aorta (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: The aorta of the octopus, Octopus dofleini, is a highly distensible, elastic tube. The circumferential elastic modulus increases with inflation in the physiological range from abut 10(4) to 10(5) newtons per square meter. Rubber-like fibers have been isolated, apparently for the first time, from the aorta of an invertebrate. These fibers have an elastic modulus, like elastin, of about 4 x 10(5) newtons per square meter and are present in sufficient quantity to account for the elastic properties of the intact vessel under physiological conditions. Thus the circulatory system of an invertebrate animal provides an "elastic reservoir" (much like that of the vertebrate system), which increases the efficiency of the circulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shadwick, R E -- Gosline, J M -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):759-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/anatomy & histology/*physiology ; Elasticity ; Octopodiformes/*physiology ; Proteins/physiology ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Studies in histocompatibility (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snell, G D -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):172-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017931" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Viral/genetics ; Antigens, Viral, Tumor ; Female ; Genetic Linkage ; Genotype ; H-2 Antigens/genetics ; Heterozygote ; *Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/genetics/*immunology ; Pedigree ; Rats ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Tumor cell killing by phorbol ester--differentiated human leukemia cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, J B -- 27070-02/PHS HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Line ; *Cytotoxicity, Immunologic ; Humans ; Immunity, Cellular ; Leukemia, Experimental/immunology/*pathology ; Macrophages/cytology/*immunology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong-Staal, F -- Dalla-Favera, R -- Franchini, G -- Gelmann, E P -- Gallo, R C -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):226-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Cell Transformation, Viral ; *Cloning, Molecular ; DNA/*genetics ; DNA, Viral/*genetics ; *Genes ; Humans ; Nucleic Acid Hybridization ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/genetics ; Sarcoma Viruses, Murine/genetics ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yogeeswaran, G -- Salk, P L -- CA19312-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233237" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/*physiology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/*physiopathology ; Sialic Acids/*analysis
    Print ISSN: 0036-8075
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  • 16
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    Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: A biologically active rhodamine conjugate of thyrotropin binds at 4 degrees C to diffusely distributed membrane thyrotropin receptors which patch and become endocytosed into thyroid cells in a temperature-sensitive process. When the cells are first incubated with 8-bromo-cyclic adenosine monophosphate at 37 degrees C, the conjugate also binds to clustered receptors at 4 degrees C. Furthermore, 8-bromo-cyclic adenosine monophosphate reduces the amount of adenosine 3',5'-monophosphate (cyclic AMP) induced by thyrotropin. Hence, increased intracellular cyclic AMP induces receptor patching and reduces the concentration of cyclic AMP normally induced by thyrotropin. This suggests that cyclic AMP acts both as the second messenger of thyrotropin and also as the regulator of the level of thyrotropin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Avivi, A -- Tramontano, D -- Ambesi-Impiombato, F S -- Schlessinger, J -- CA-25820/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272396" target="_blank"〉PubMed〈/a〉
    Keywords: 8-Bromo Cyclic Adenosine Monophosphate ; Animals ; Cell Line ; Cell Membrane/drug effects/metabolism ; Cyclic AMP/*analogs & derivatives/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/drug effects/*metabolism ; Receptors, Thyrotropin ; Thyroid Gland/metabolism ; Thyrotropin/*metabolism/pharmacology
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  • 17
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    Immunology of archaebacteria that produce methane gas (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: The antigenic map of 17 methanogenic bacteria representing the entire range of available species was determined by multiple assay with antibody probes. Four major clusters of antigenically related strains coincide with the females proposed on the basis of 16S ribosomal RNA analysis. Immunological mapping uncovered relationships not yet shown by other methods and allowed identification and classification of two new bacterial isolates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conway de Macario, E -- Wolin, M J -- Macario, A J -- NIAID AI-12461/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):74-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792708" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Bacterial/*analysis ; Archaea/classification/*immunology ; Bacteria/*immunology ; Euryarchaeota/classification/*immunology ; Species Specificity
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  • 18
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    Substance P activity in the bullfrog retina: localization and identification in several vertebrate species (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: Immunoreactive substance P is present in the bullfrog retina, possibly in two types of stratified amacrine cells, with their somas in the inner nuclear layer and their neuronal processes entering the inner plexiform layer and ramifying in sublayers 3 or 4 (or both). Occasionally, polygonal somas positive for substance P were found in the ganglion cell layer. Approximately 75 percent of the cell bodies positive for substance P and 65 percent of the radioimmunoassayable substance P were found in the superior half of the frog retina. On the basis of high-performance liquid chromatography, the immunoreactive substance P in the neural retina of the rat, monkey, or chick is similar to synthetic substance P, whereas this is not true of the immunoreactive substance P in the bullfrog or carp retina.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eskay, R L -- Furness, J F -- Long, R T -- New York, N.Y. -- Science. 1981 May 29;212(4498):1049-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6165081" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chickens ; Fluorescent Antibody Technique ; Macaca ; Rana catesbeiana ; Rats ; Retina/analysis/*cytology ; Species Specificity ; Substance P/*analysis
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  • 19
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    Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-06
    Description: The etiologic agent of Korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. The cells, described as type II, alveolar epithelial, support replication of the agent and successive passages. Antigen of the Korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. Previous attempts to propagate this agent in vitro had been unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉French, G R -- Foulke, R S -- Brand, O A -- Eddy, G A -- Lee, H W -- Lee, P W -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1046-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6110243" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Viral/analysis ; Cell Line ; Hantavirus/*growth & development/immunology ; Hemorrhagic Fever with Renal Syndrome/*microbiology ; Humans ; Pulmonary Alveoli/microbiology ; RNA Viruses/*growth & development
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  • 20
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    Estradiol and progesterone profiles indicate a lack of endocrine recognition of pregnancy in the opossum (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: Concentrations of estradiol and progesterone in blood collected during the 12.5-day gestation period of the Virginia opossum were not significantly different from those during equivalent days of the estrous cycle. Progesterone was correlated with an index of corpora luteral mass. Ratio of estradiol to progesterone were highest 3 to 4 days before estrus and on the day of parturition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harder, J D -- Fleming, M W -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corpus Luteum/physiology ; Estradiol/*blood ; Estrus ; Female ; Opossums/*physiology ; Pregnancy ; *Pregnancy, Animal ; Progesterone/*blood ; Species Specificity
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  • 21
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    Somatic cell hybrids from frog lymphocytes and mouse myeloma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: Stable somatic cell hybrids were obtained by fusing Xenopus lymphocytes with mouse myeloma cells. These hybrids contained one to four Xenopus chromosomes and expressed Xenopus gene products, one of which was a lymphocyte membrane protein of 85,000 daltons precipitated by a monoclonal antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hengartner, H -- Du Pasquier, L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1034-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antibodies, Monoclonal ; Cell Line ; Clone Cells ; Genes ; Hybrid Cells/*physiology ; Lymphocytes/*physiology ; Membrane Proteins/biosynthesis ; Mice ; Molecular Weight ; Neoplasms, Experimental/physiopathology ; Plasmacytoma/*physiopathology ; Xenopus
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  • 22
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
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  • 23
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    Rapid induction of cellular strain specificity by newly acquired cytoplasmic components in amoebas (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorch, I J -- Jeon, K W -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):949-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466367" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/genetics/microbiology/*physiology ; Animals ; Cell Nucleus/physiology ; Cytoplasm/physiology ; Species Specificity ; *Symbiosis
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  • 24
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    Owl monkey cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus ; Cell Line ; Hodgkin Disease/*pathology ; Humans ; Phenotype
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  • 25
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    Psychoneuroendocrine influences on immunocompetence and neoplasia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Emotional, psychosocial, or anxiety-stimulated stress produces increased plasma concentrations of adrenal corticoids and other hormones though well-known neuroendocrine pathways. A direct consequence of these increased corticoid concentrations is injury to elements of the immunological apparatus, which may leve the subject vulnerable to the action of latent oncogenic viruses, newly transformed cancer cells, or other incipient pathological processes that are normally held in check by an intact immunological apparatus. This article describes studies that examine the adverse effects of increased plasma concentrations of adrenal corticoids on the thymus and thymus-dependent T cells, inasmuch as these elements constitute a major defense system against various neoplastic processes and other pathologies. The studies demonstrate that anxiety-stress can be quantitatively induced and the consequences measured through specific biochemical and cellular parameters, providing that authentic quiescent baselines of these conditions are obtained in the experimental animals by the use of low-stress protective housing and handling techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- CA 12188/CA/NCI NIH HHS/ -- CA 16308/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1100-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticosterone/blood ; Female ; Handling (Psychology) ; Humans ; *Immunocompetence ; Leukocytes/physiology ; Mice ; Mice, Inbred Strains ; Neoplasms/*etiology/physiopathology/psychology ; Neoplasms, Experimental/*physiopathology ; Species Specificity ; Stress, Physiological/*complications ; Stress, Psychological/*complications ; Tumor Virus Infections/physiopathology
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  • 26
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    Dissections and reconstructions of genes and chromosomes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, P -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):296-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosomes/*physiology/ultrastructure ; DNA Restriction Enzymes ; DNA, Recombinant ; DNA, Viral/genetics ; *Genes ; Histones ; Humans ; Plasmids ; RNA, Messenger/genetics ; Simian virus 40/genetics ; Transduction, Genetic
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  • 27
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    Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: Isolated hydra mesoglea served as a suitable substrate for the attachment and spreading of hydra cells in vitro, irrespective of the species tested. Hydra cells did not attach and spread on substrates typically used for culturing mammalian cells. Mammalian and Drosophila cells attached and spread on plastic culture dishes but not on isolated mesoglea. Xenopus epithelial cells spread on both plastic and mesoglea. Because of the similarities of hydra mesoglea to vertebrate basement membranes, suggestions are offered for using mesoglea to study the interactions of epithelial cells with their basement membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, R M -- Lenhoff, H M -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):291-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/physiology ; Biological Evolution ; Cell Adhesion ; Cell Line ; Epithelial Cells ; Extracellular Space/physiology ; Hydra/*cytology ; Species Specificity
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  • 28
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    Lophotoxin: a novel neuromuscular toxin from Pacific sea whips of the genus Lophogorgia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: A new neuromuscular toxin, lophotoxin, has been isolated from several pacific gorgonians of the genus Lophogorgia. The structure of lophotoxin was deduced by combined spectrochemical methods, and belongs to the well-known cembrene class of diterpenoid molecules. Lophotoxin contains furanoaldehyde and alpha, beta-epoxy-gamma-lactone functional groups, in sharp contrast to the cationic ammonium functional groups of the established neurotoxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fenical, W -- Okuda, R K -- Bandurraga, M M -- Culver, P -- Jacobs, R S -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1512-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6112796" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cnidaria/*analysis ; Cnidarian Venoms/*isolation & purification/pharmacology ; Diterpenes/*isolation & purification/pharmacology/toxicity ; Electric Stimulation ; Mice ; Muscle Contraction/drug effects ; Muscles/innervation ; Neuromuscular Junction/drug effects/physiology ; Species Specificity ; *Terpenes
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  • 29
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    Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-04
    Description: The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kazmers, I S -- Mitchell, B S -- Dadonna, P E -- Wotring, L L -- Townsend, L B -- Kelley, W N -- AM 19045/AM/NIADDK NIH HHS/ -- CA 26032/CA/NCI NIH HHS/ -- CA 26284/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795718" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/enzymology ; Cell Line ; Deoxyguanosine/pharmacology ; Guanosine/*analogs & derivatives/pharmacology ; Humans ; Kinetics ; Pentosyltransferases/*antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/*antagonists & inhibitors ; T-Lymphocytes/drug effects/*enzymology
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    Carcinogens and regulation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lappe, M -- Hooper, K -- Blake, E -- Pfund, N -- Gardner, E -- Rosenberg, J -- New York, N.Y. -- Science. 1981 Jan 23;211(4480):332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221543" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; *Carcinogens ; Dose-Response Relationship, Drug ; Humans ; Species Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 31
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    Plasminogen activator release at the neuronal growth cone (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-25
    Description: The site of plasminogen activator release by differentiated neuroblastoma clonal cell lines was determined with a fibrin overlay assay. Release of plasminogen activator was seen at the growth cone in 72 percent of the cells bearing neurites. For 21 percent of these cells the growth cone was the predominant or exclusive site of this enzyme activity. Selective release of protease at the "trailblazing" tip of the neurite may be important in neuron migration and neurite growth in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krystosek, A -- Seeds, N W -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1532-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197054" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; *Cell Movement ; Cytochalasin B/pharmacology ; Fibroblasts/metabolism ; Mice ; Neuroblastoma ; Neurons/cytology/*enzymology ; Plasminogen Activators/*metabolism/secretion ; Secretory Rate/drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 32
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    Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-03
    Description: Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, N J -- Krohn, K J -- Mathis, C A -- Chasko, J H -- Geiger, K R -- Gregor, M E -- Peek, N F -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Nitrates/administration & dosage/*metabolism ; Nitrites/administration & dosage/*metabolism ; Nitrogen Isotopes ; Oxidation-Reduction ; Rabbits ; Species Specificity ; Tissue Distribution ; Trachea
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  • 33
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    Neural gonadal steroid actions (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-20
    Description: Neurons sensitive to gonadal steroids are located strategically within neural circuits that mediate behaviors broadly related to the reproductive process. Some neuronal events and properties are regulated by these hormones. Variability in the occurrence and distribution of particular neural hormonal sensitivities across species may be related to variations in the hormonal requirements for sexual differentiation and for activation of reproductive behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McEwen, B S -- NS07080/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1303-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259728" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism/physiology ; Animals ; Brain/enzymology/metabolism ; Estrogens/metabolism/physiology ; Female ; Gonadal Steroid Hormones/*physiology ; Gonads/secretion ; Humans ; Male ; Neurons/metabolism ; Progestins/metabolism ; Rats ; Receptors, Cell Surface/metabolism ; Receptors, Progesterone/metabolism ; *Sex Differentiation ; *Sexual Behavior ; Species Specificity ; Vertebrates/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    High levels of intracellular bombesin characterize human small-cell lung carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-11
    Description: "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moody, T W -- Pert, C B -- Gazdar, A F -- Carney, D N -- Minna, J D -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272398" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/analysis ; Bombesin/*analysis ; Carcinoma, Small Cell/*analysis ; Carcinoma, Squamous Cell/analysis ; Cell Line ; Humans ; Lung Neoplasms/*analysis ; Mesothelioma/analysis ; Peptides/*analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Species-typical behavior of hamsters deprived from birth of the neocortex (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: Hamsters deprived from birth of the neocortex developed normally and displayed the usual hamster-typical behavioral patterns. With the additional concurrent destruction of midline limbic convolutions (cingulate and underlying dorsal hippocampal), there were deficits in maternal behavior and a lack of development of play behavior. These findings demonstrate in a rodent (i) that the striatal complex and limbic system, along with the remaining neuraxis, are sufficient for giving expression to a wide range of unlearned forms of species-typical behavior and (ii) that midline limbic structures are required for the expression of play behavior and the integrated performance of maternal behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, M R -- MacLean, P D -- Hamilton, S C -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244642" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Behavior, Animal ; Cerebral Cortex/*physiology ; Cricetinae ; Mesocricetus ; Species Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    Cross-contamination of cells in culture (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: Lists are presented of references to all known publications describing cell properties that serve to characterize (i) known strains of HeLa and purported human cell lines indicated as HeLa contaminants, (ii) strains of human cell lines contaminated with human but non-HeLa cells, and (iii) strains of cells contaminated by cells from one or more other species. Frequencies of cell cross-contaminations are cited and references are presented to relatively simple techniques that could serve to detect such contamination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson-Rees, W A -- Daniels, D W -- Flandermeyer, R R -- YO1 CP8-0500/CP/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):446-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6451928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Line ; Cells, Cultured/enzymology/*physiology ; Glucosephosphate Dehydrogenase/analysis ; Humans ; Isoenzymes/analysis ; Karyotyping ; Phosphoglucomutase/analysis ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 37
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    Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollard, M -- Luckert, P H -- CA 00295/CA/NCI NIH HHS/ -- CA 15957/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):558-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dimethylnitrosamine/*analogs & derivatives/antagonists & inhibitors ; Indomethacin/*pharmacology ; Intestinal Neoplasms/*chemically induced ; Male ; Neoplasms, Experimental/chemically induced ; Rats ; Rats, Inbred Strains ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sires, L R -- Hruby, S -- Alvord, E C Jr -- Hellstrom, I -- Hellstrom, K E -- Kies, M W -- Martemspm, R -- Deibler, G E -- Beckman, E D -- Casnellie, J E -- CA-19148/CA/NCI NIH HHS/ -- CA-25558/CA/NCI NIH HHS/ -- CA-26584/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169147" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Cattle ; Chickens ; Epitopes ; Guinea Pigs ; Humans ; Macaca ; Myelin Basic Protein/*immunology ; Peptide Fragments/immunology ; Rabbits ; Rats ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Induction of hemoglobin accumulation in human K562 cells by hemin is reversible (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in K562 cells does not depend on irreversible differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dean, A -- Erard, F -- Schneider, A P -- Schechter, A N -- AM 00103/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163216" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation/drug effects ; Cell Line ; Fetal Hemoglobin/biosynthesis ; Gene Expression Regulation/drug effects ; Heme/*analogs & derivatives ; Hemin/*pharmacology ; Hemoglobins/*biosynthesis ; Humans
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    Efferents to the retina have multiple sources in teleost fish (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Multiple efferent systems project to the retina in three species of teleost fish investigated with the horseradish peroxidase technique. These animals are the first vertebrates shown to have more than one central nervous system structure projecting to the retina. The connections discovered may reflect a primitive organization of retina-brain interconnections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ebbesson, S O -- Meyer, D L -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):924-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Efferent Pathways/*physiology ; Fishes ; Horseradish Peroxidase ; Retina/*physiology ; Species Specificity
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    5-Methylcytosine in eukaryotic DNA (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side. This methylation of eukaryotic DNA has been proposed to function in many ways, including control of transcription, maintenance of chromosome structure, repair of DNA, establishment of preferred sites for mutation, oncogenic transformation, and, in certain systems, protection of DNA against enzymatic degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrlich, M -- Wang, R Y -- CA-19942/CA/NCI NIH HHS/ -- GM-26986/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1350-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262918" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Animals ; Base Sequence ; Cytosine/*analogs & derivatives/analysis ; DNA/*genetics ; DNA Replication ; DNA Restriction Enzymes/metabolism ; *Genes ; Methylation ; Pyrimidines ; Species Specificity ; Substrate Specificity ; Transcription, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    Temporal coding of species recognition signals in an electric fish (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: An electric fish in the African family Mormyridae recognizes members of its own species by "listening" to electric organ discharges, which are species-specific signatures. Reactions of fish in the field and of individual electroreceptors to both normal and modified computer-synthesized discharges emphasize the importance of the waveform (time-domain cues) in species recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hopkins, C D -- Bass, A H -- MH26140/MH/NIMH NIH HHS/ -- NS06309/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209524" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Electric Organ/*physiology ; Female ; Fishes/*physiology ; Male ; Sex Factors ; Sexual Behavior, Animal/physiology ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 43
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    Warburg effect revisited: merger of biochemistry and molecular biology (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Racker, E -- Spector, M -- CA-08964/CA/NCI NIH HHS/ -- CA-14454/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):303-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264596" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*metabolism ; Animals ; Avian Sarcoma Viruses/metabolism ; Brain/*enzymology ; Carcinoma, Ehrlich Tumor/*metabolism ; Cell Line ; Cell Transformation, Neoplastic ; Electric Organ/enzymology ; Electrophorus ; *Glycolysis/drug effects ; Macromolecular Substances ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Ouabain/pharmacology ; Oxidation-Reduction ; Polyomavirus/metabolism ; Protein Kinases/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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