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  • Articles  (4,517)
  • Springer  (4,517)
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  • 1990-1994
  • 1980-1984  (4,517)
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  • 1980  (4,517)
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  • Articles  (4,517)
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  • 1990-1994
  • 1980-1984  (4,517)
  • 1940-1944
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  • 1
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    Bulletin of mathematical biology 42 (1980), S. 131-135 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The theory of complementary variational principles is used to obtain maximum and minimum principles for diffusion problems with Michaelis-Menten kinetics. In an illustrative calculation we obtain an extremely accurate variational solution in good agreement with the numerical solution of McElwain (1978).
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  • 2
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    Bulletin of mathematical biology 42 (1980), S. 137-141 
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  • 3
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    Bulletin of mathematical biology 42 (1980), S. 181-189 
    ISSN: 1522-9602
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    Notes: Abstract Necessary and sufficient conditions for primitivity of a product of two Leslie matrices are given. Such a product could be used in modeling the growth of a population governed alternately by two different sets of fertility and survival parameters.
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  • 4
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    Bulletin of mathematical biology 42 (1980), S. 173-180 
    ISSN: 1522-9602
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    Notes: Abstract Zadeh's transfer function method for linear time-variable systems is used to apply frequency-domain analysis to a periodically time-varying elastance model of the left ventricle. Left ventricular pressure computed from the system function of the time-varying elastance and the phasors of aortic flow shows a typical waveform of the measured ventricular pressure.
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  • 5
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    Bulletin of mathematical biology 42 (1980), S. 901-901 
    ISSN: 1522-9602
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  • 6
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    Bulletin of mathematical biology 42 (1980), S. 147-160 
    ISSN: 1522-9602
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    Notes: Abstract A theory of noise fluctuations is developed which is applicable to systems of any size in which unimolecular or bimolecular reactions are occurring. The main difference between small and large reacting systems is that in the former the probability of finding a particle in a particular state does not obey a Gaussian distribution, but satisfies a distribution which reflects the mechanism of the chemical reaction. This difference is reflected in the main result of the theory: an autocorrelation function that is expressible as a sum of exponentials, the amplitudes of which are explicit functions of the moments of the distribution. Thus, by using small systems, the autocorrelation function,in principle, allows the elucidation of reaction mechanisms. Numerical simulations indicate that for reacting systems having ten or fewer particles, the deviation of the autocorrelation function from a single exponential should be easily detectable, and that estimates of the first four moments of the distribution should be possible. Accurate inference of the distribution, however, will require further mathematical and experimental advances.
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  • 7
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    Bulletin of mathematical biology 42 (1980), S. 161-172 
    ISSN: 1522-9602
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    Notes: Abstract The recent mathematical formalization of the concepts of matter and extrinsical energy, which are used for the relational representation of biological systems, is employed in the analysis of the important experimental discoveries of Comorosanet al. related to low energy electromagnetic irradiations on enzyme substrates. By means of the present analysis one of the properties inherent to the experimental phenomena is more precisely exposed, and theoretical developments corresponding to “energetical evolutions” in a biological system (Leguizamón, 1976) may now have an experimental basis. Important limitations are introduced for the validity of the commutativity and associativity of cartesian product of sets, when they represent matter and its linked extrinsical energy. In connection with this last aspect, new important knowledge is obtained for the relational mathematical representation of biological systems.
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  • 8
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    Bulletin of mathematical biology 42 (1980), S. 397-429 
    ISSN: 1522-9602
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    Notes: Abstract The structure of solutions to a simple spatially dependent population model involving growth and death is investigated. Two forms of motility of the population are considered: (1) random motion only modeled by a Fickian law, and (2) a directed component of motion (chemotaxis), included in addition to the random motion. Under certain growth conditions a traveling wave of constant speed is approached. This speed can be increased by the addition of the chemotaxis with a corresponding increase in the asymptotic population. Development of initial conditions into a wave is illustrated numerically.
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  • 9
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    Bulletin of mathematical biology 42 (1980), S. 365-396 
    ISSN: 1522-9602
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    Notes: Abstract This paper describes mechanisms of intracellular and intercellular adaptation that are due to spatial or temporal factors. The spatial mechanisms support self-regulating pattern formation that is capable of directing self-organization in a large class of systems, including examples of directed intercellular growth, transmitter production, and intracellular conductance changes. A balance between intracellular flows and counterflows causes adaptation. This balance can be shifted by environmental inputs. The decrease in Ca2+-modulated outward K+ conductance in certain molluscan nerve cells is a likely example. Examples wherein Ca2+ acts as a second messenger that shunts receptor sensitivity can also be discussed from this perspective. The systems differ in basic ways from recent diffusion models. Chemical transducers driven by membrane-bound intracellular signals can establish long-range intercellular interactions that compensate for variable intercellular distances and are invariant under developmental size changes; diffusional signals do not. The intracellular adaptational mechanisms are formally analogous to intercellular mechanisms that include cellular properties which are omitted in recent reaction-diffusion models of pattern formation. The cellular models use these properties to compute size-invariant properties despite wide variations in their intercellular signals. Mechanisms of temporal adaptation can be derived from the simplest laws of chemical transduction by using a correspondence principle. These mechanisms lead to such properties of intercellular signals as transient overshoot, antagonistic rebound, and an inverted U in sensitivity as intracellular signals or adaptation levels shift. Such effects are implicated in studies of behavioral, reinforcement, motor control, and cognitive coding.
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    Bulletin of mathematical biology 42 (1980), S. 447-459 
    ISSN: 1522-9602
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    Notes: Abstract Large radiation doses to the lung can cause early death from cardiopulmonary insufficiency resulting from radiation pneumonitis and pulmonary fibrosis. A model for early death following inhalation of insoluble radioactive particles is propose. The model is based on three assumptions: (1) early death results from damage to a cluster of cells from a large number of cell clusters at risk, (2) the dose that causes early death depends on how the radiation is delivered in time and (3) the cell clusters at risk to damage are equally sensitive ro radiation. Results from asymptotic theory of extreme values, along with biophysical considerations, suggest that the cumultive distribution function for the absorbed radiation dose to the production of pulmonary injury sufficient to cause early death is best estimated by the third asymptotic distribution without a threshold. This distribution function is identical to the Weibull cumulative distribution function. Data for Beagle dogs after inhaling relatively insoluble forms of alpha- or beta-gamma-emitting particles are shown to support the Weibull model.
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  • 11
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    Bulletin of mathematical biology 42 (1980), S. 461-480 
    ISSN: 1522-9602
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    Notes: Abstract Models of the human respiratory tract were developed based on detailed morphometric measurements of a silicone rubber cast of the human tracheobronchial airways. Emphasis was placed on the “Typical Path Lung Model” which used one typical pathway to represent a portion of the lung, such as a lobe, or to represent the whole lung. The models contain geometrical parameters, including airway segment diameters, lengths, branching angles and angles of inclination to gravity, which are needed for estimating inhaled particle deposition. Aerosol depositions for various breathing patterns and particle sizes were calculated using these lung models and the modified Findeisen-Landahl computational scheme. The results agree reasonably well with recent experimental data. Regional deposition, including lobar deposition fractions, are also calculated and compared with results based on the ICRP lung deposition model.
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  • 12
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    Bulletin of mathematical biology 42 (1980), S. 481-488 
    ISSN: 1522-9602
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    Notes: Abstract The completely symmetrical system is defined as having identical transfer coefficients between pairs of compartments and the same loss coefficient for each compartment. The eigenvalues and eigenvector are explicitly found along with the inverses of the system matrix and the matrix of eigenvectors. Many properties, special instances of more general theorems, can be seen at once from the explicit analytic solution of the initial value, washout and washin problems. The system serves as a known case for testing estimation procedures, algorithms for solutions of linear systems, eigenvalue-eigenvector and inversion routines and is of considerable tutorial value.
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  • 13
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    Bulletin of mathematical biology 42 (1980), S. 431-446 
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    Notes: Abstract The mathematical structures underlying the theories of organismic sets, (M, R)-systems and molecular sets are shown to be transformed naturally within the theory of categories and functors. Their natural transformations allow the comparison of distinct entities, as well as the modelling of dynamics in “organismic” structures.
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    Bulletin of mathematical biology 42 (1980), S. 489-505 
    ISSN: 1522-9602
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    Notes: Abstract To explain the sodium conductance change using Wei's dipole model (Wei, 1969), we may expect that during depolarization the dipole's population difference, ΔN, is first reduced and then returns more slowly to its resting value. This paper shows that the experimental results of gating currents support this idea. Such time course of ΔN, however, is not a usual relaxation process. To account for the unusual behavior of ΔN, we propose two additional assumptions: (1) there exists a special coupling system (probably the intramolecular vibrations) whose coupling strength with the dipoles is much stronger than with the thermal bath (intermolecular vibrations), and (2) there also exist “traps” for the dipole's excitation energy so that this energy is transformed into other energy forms at a rate increasing with the increase of depolarization. Experiments suggest that the traps are proteins located at the inner membrane surface.
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    Bulletin of mathematical biology 42 (1980), S. 507-528 
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    Notes: Abstract Current research into the dynamics of iterative ecological and biological models has lead to a number of theorems concerning the existence of various types of iterative dynamical behavior. In particular, much study has been done on the dynamical behavior of the “simplest dynamical system”f b(x)=bx(1−x), which is just the canonical discrete form of logistic growth equations found in ecology, sociobiology, and population biology. In this paper, we make use of some of the techniques and concepts of topological dynamics to construct a number of generalized conjugacy theorems. These theorems are then used to demonstrate that the mappingf b has a number of conjugacy classes in which the dynamics of the iterates is equivalent to within a change of variables. The concepts of fitness and survival in logistic equations are then shown to be independent, if we follow certain intuitive definitions for these concepts. This conclusion follows from a comparison of the conjugacy classes of the functionf b and the extinction sets off b.
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    Notes: Abstract For chemical reactions not at equilibrium but proceeding in the forward direction in the steady state, a result found by a method first introduced by H. G. Britton (1963, 1965) is generalized to prove that if $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is the unidirectional flux ratio, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ exp (−ΔG/RT). The conditions under which the equality or inequality applies are discussed. If the unidirectional fluxes are not in the steady state, the unidirectional flux ratio is time invariant in certain specific situations. One such important case is for chemical reaction systems with an ordered sequence of reactions. For systems with more than one pathway, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is not constant except for special cases. These results also apply to diffusional and active transport systems.
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    Bulletin of mathematical biology 42 (1980), S. 599-600 
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    Bulletin of mathematical biology 42 (1980), S. 539-549 
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    Bulletin of mathematical biology 42 (1980), S. 551-597 
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    Notes: Abstract The nonlinear second-order difference equationx n+1=axn(1-xn−1), where 0≦x nX≦1 anda ≧1, is examined from varying points of view, analytical, numerical and geometrical. An analytic expression is obtained for an invariant attracting curveC ∞ (a) in phase space, which becomes the central object of study. This basic curve, which replaces the simple parabolic shape typical of many analogous first-order models, may have a complicated geometrical structure. As the parametera increases,C ∞(a) undergoes transformations characterized by the dynamical descriptions: stable node→stable focus→stable limit cycle →chaotic attractor. Although the limited characterization ofchaos by the appearance of nonperiodic solutions and solutions of arbitrarily large period is relied upon, this appears to be only a simplified approximation of the real behavior of solutions. Trajectories (x n, xn+1),n=0,1,…, are calculated using the related nonlinear planar mapT a(x,y)=(y,ay(1−x)), and regions of persistence and escape are described for characteristic values ofa. The study of persistence, of even more fundamental interest than the associated problems of periodicity and stability, receives special attention. We introduce a geometrical model, similar in many respects to that for the well-known analoguex n+1=axn(1−x n), but having several new and important features. It appears that as the parametera increases in the chaotic regime there are infinitely many intermittent bursts of increase in the probability that any initial point (x 0, x1) will persist in the unit square under successive iterations of the mappingT a, an unexpected property that should be of interest for applications. A discussion of the applicability of these results to population dynamics theory is given, and it is suggested that such equations might find useful application to problems in developmental biology as well.
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    Bulletin of mathematical biology 42 (1980), S. 627-645 
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    Notes: Abstract Based on the principle of minimum power, a mathematical model of the functional state of the oxygen transport system is presented. The optimization model minimizes the power expenditure of the heart, bone marrow, lung and other tissues. The model is used to determine the functional parameters of the oxygen transport system in man under both normal and varying barometric pressures. Theoretical results are compared with experimental data.
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    Bulletin of mathematical biology 42 (1980), S. 601-625 
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    Notes: Abstract A quantitative model of ion binding and molecular interactions in the lipid bilayer membrane is proposed and found to be useful in examining the factors underlying such membrane characteristics as shape, sidedness, stability and vesicle size at various cation concentrations. The lipid membrane behaves as a bilayer couple whose preferential radius of curvature depends on the expansion or contraction of one monolayer relative to the other. It is proposed that molecular packing may be altered by electrostatic repulsion of adjacent like-charged phospholipid headgroups, or by bringing two headgroups closer together by divalent cation crossbridging. The surface concentrations of each type of cation-phospholipid complex can be described by simple binding equilibria and the Gouy-Chapman-Stern formulation for the surface potential in a diffuse double layer. The asymmetric distribution of acidic phospholipids in most biological membranes can account for the differential effects of identical ionic environments on either side of the bilayer. The fraction of vesicle material which tends to have a right-side-out orientation may be approximated by a normal distribution about the mean curvature. The theory generates vesicle sidedness distributions that, when fitted to experimental results from human erythrocyte membranes, provide an alternative method of estimating intrinsic cationphospholipid dissociation constants and other molecular parameters of the bilayer. The results also corroborate earlier suggestions that the Gouy-Chapman theory tends to overestimate free counter-ion concentrations at the surface under large surface potentials.
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    Bulletin of mathematical biology 42 (1980), S. 681-689 
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    Notes: Abstract The “yellow strips” on the cuticle of the Oriental Hornet (Vespa orientalis, Hymenoptera, Vespinae), present photoelectric properties. A mathematical model for the relative changes in resistance as a photoconductive process conforms to the general model for a semiconductor with traps.
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    Bulletin of mathematical biology 42 (1980), S. 701-718 
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    Notes: Abstract Damped nonlinear oscillations in biological and biochemical systems are investigated by the extended Krylov-Bogoliubov-Mitropolskii (KBM) method. A review on the extension made by Popov to the KBM method is given and also further improvements are presented. Applications are made to models of oscillating chemical reactions (Lefever and Nicolis, 1971), FitzHugh (1961) equations, and population dynamics (Gatto and Rinaldi, 1977). Comparison to damped oscillating physical and engineering systems is made.
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    Bulletin of mathematical biology 42 (1980), S. 719-728 
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    Notes: Abstract The conditions that will allow the lumping together of several age classes in the Leslie model are investigated. We show that if the lumping is to be valid for all population distributions, then the parameters of the model must be periodic. Lumping is valid when the population is in equilibrium, but equilibrium should be tested before the model is lumped.
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    Bulletin of mathematical biology 42 (1980), S. 647-679 
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    Notes: Abstract Catastrophe theory is a mathematical theory which, allied with a new and controversial methodology, has claimed wide application, particularly in the biological and the social sciences. These claims have recently been heatedly opposed. This article describes the debate and assesses the merits of the different arguments advanced.
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    Bulletin of mathematical biology 42 (1980), S. 765-795 
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    Notes: Abstract Estimates of capillary tracer permeability calculated using multiple indicator data depend upon the particular model adopted to describe blood tissue exchange. The model proposed by Crone (1963) is appropriate when some of the injected tracer diffuses into the tissue but does not return appreciably to the bloodstream before data collection is terminated. Under these conditions extraction of tracer by the tissue depends on a single dimensionless parameter, αcap, defined as the ratio of capillary permeability surface area to water flow. The effects of finite red cell tracer permeability on the Crone model estimate of capillary permeability are examined in the present study. The results indicate that even when back diffusion from the extravascular space is negligible, significant errors in the Crone model estimate can be expected when capillary permeability is relatively high and the ratio of red cell to capillary permeability is less than unity. However, when an aliquot of blood is equilibrated with tracer prior to injection and the dimensionless capillary permeability is relatively low (i.e. αcap ≦ 0.25 for a haematocrit≦50%), the whole blood Crone model estimate of αcap will be within 10% of the actual value, irrespective of red cell permeability. Red cell-plasma exchange for commonly used tracer-organ combinations should not significantly affect Crone estimates of capillary permeability under normal physiological conditions, but may be important in low flow situations.
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    Bulletin of mathematical biology 42 (1980), S. 807-828 
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    Notes: Abstract Assuming truncated ellipsoidal geometry for the right and left ventricles, a model is developed for the myocardium enabling biventricular mechanical behavior to be studied. Employing pressure-volume data taken from normal dog hearts and from hearts in which the pulmonary artery has been banded over periods of 2–40 weeks, it is shown that: (a) right ventricular wall stresses are higher than left ventricular stresses; (b) right ventricular wall stress increases initially to a maximum after 3–4 weeks followed by a decline to normal and even subnormal levels, attaining a minimum value at 32–33 weeks; (c) left ventricular stresses behave in a similar manner, attaining their maximum and minimum levels after 7–8 weeks and 32–33 weeks respectively. These results suggest that surgical or medical therapy in patients with hypertrophied ventricles might be more appropriate during the period of wall stress reduction.
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    Bulletin of mathematical biology 42 (1980), S. 837-845 
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    Notes: Abstract In this paper we describe a mathematical model of the oscillations of the diaphragm which limits the vitreous body from the anterior segment of the human eye after the lens has been removed in a cataract operation. We study the motion of this diaphragm driven by movements of the eye. Firstly, a mathematical statement of the problem is given and then we solve the problem exactly for a given class of eye movements. From the analysis we deduce that significant oscillations of the membrane are driven by saccades and that it is the angular acceleration of the eye which causes these types of oscillations. A numerical example is given.
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    Bulletin of mathematical biology 42 (1980), S. 871-887 
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    Notes: Abstract The Lotka-Volterra system of prey-predator equations is considered with a special type of continuous time delay. In the case of equal diffusion coefficients Hopf’s bifurcation technique is used to show the existence of travelling wave train solutions for the prey-predator system.
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    Bulletin of mathematical biology 42 (1980), S. 861-870 
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    Notes: Abstract A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.
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    Bulletin of mathematical biology 42 (1980), S. 847-859 
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    Notes: Abstract A new model of the upper tracheobronchial tree is proposed to account for the three-dimensional nature of the airway system. In addition to the tube length, the tube diameter, and the branching angle, the model includes information on the orientation angle of each tube relative to its parent tube. The orientation angle, defined as the angle between two successive bifurcations, is useful for calculating the gravitational inclination of each tube. The information on orientation angle is further used to construct a binary coding system for identifying individual tubes in the airway tree. The proposed model is asymmetrical, but the same principles can be readily used to construct a symmetrical one.
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    Bulletin of mathematical biology 42 (1980), S. 889-897 
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    Notes: Abstract In any control system for which the number of independent controls is smaller than the number of degrees of freedom to be controlled, our choice of control in any state is restricted to a submanifold of smaller dimension than the tangent space. This simple fact has a number of important consequences for questions of biological import; we consider its implications for adaptation, for senescent phenomena and for the determination of tertiary structures of polypeptides through control of certain average properties. We also formulate the Pontryagin Maximum Principle of Optimal control theory in such a way as to inquire whether specific biodynamic systems can be regarded as optimal with respect to rate of accumulation of particular quantities of the system. We find that if this is possible, the quantity in question must play the role of a clock.
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    Bulletin of mathematical biology 42 (1980), S. 899-900 
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    Bulletin of mathematical biology 42 (1980), S. 1-15 
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    Notes: Abstract A computational model to predict deposition of a wide variety of particulate pollutants in several species of mammals is presented. The model incorporates breathing pattern and detailed anatomical models of the respiratory tract based on extensive morphometric measurements of individual airways. The predicted deposition from this general model is in close agreement with observed deposition of monodisperse aerosols in rats. Particle size and density and respiratory breathing patterns are the critical parameters affecting regional deposition.
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    Bulletin of mathematical biology 42 (1980), S. 17-36 
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    Notes: Abstract A theory of antigen-antibody induced particulate aggregation is developed by investigating the stability of model systems of particles. Conditions for the formation of large aggregates are derived by imposing the requirement that at equilibrium a statistically significant number of redundant bonds would occur in a reduced monomer-dimer model system. A relationship is obtained which predicts the fractional agglutination in the reduced dimer system as a function of the antigen, antibody and particulate concentrations: $$\frac{g}{{2f c_0 (1 - g)^{2^ - } }} = \frac{{s_1 }}{r} + \frac{{s_1 s_2 }}{{2!r^2 }} + ... + \frac{{s_1 s_2 ...s_j }}{{j!r^j }},$$ wherec 0 is the initial concentration of monomer,f is a proximity factor,g is the fractional agglutination,s i is the average rate of formation of theith bond from an (i−1)th bound dimer, andr is the average rate of dissociation of a single antibody-antigen bond.
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    Bulletin of mathematical biology 42 (1980), S. 37-56 
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    Notes: Abstract The roles of the concentrations of the three interacting constituents in the aggregation process (antibodies, antigens and particulates) are analyzed in detail. It is shown that the basic equation derived in Part I is consistent over a broad range of conditions with experimental findings previously reported.
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    Bulletin of mathematical biology 42 (1980), S. 57-78 
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    Notes: Abstract A general mathematical model describing the biochemical interactions of the hormones luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH) and testosterone (T) in the male is presented. The model structure consists of a negative feedback system of three ordinary differential equations, in which the qualitative behavior is either a stable constant equilibrium solution or oscillatory solutions. A specific realization of the model is used to describe the experimental observations of pulsatile hormone release, its experimental suppression, the onset of puberty, the effects of castration, and several other qualitative and quantitative results. This model is presented as a first step in understanding the physicochemical interactions of the hypothalamic-pituitary-gonadal axis.
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    Bulletin of mathematical biology 42 (1980), S. 79-94 
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    Notes: Abstract Based upon the transition rate equation of dipoles in the membrane, we deal with two important aspects of interaction of nerve signals: (1) conditions for nerve excitation and (2) frequency spectrum analysis of nerve impulse. Interrelations between signal amplitudes and frequencies are formulated in detail. There are several important conclusions which can be drawn from our calculations. First, toexcite the nerve, low frequencies are generally more effective than high frequencies. Second, tosedate the nerve (i.e. to suppress undesired activities), high frequencies would suit better. Third, harmonics produced through interactions of nerve signals are not necessarily weaker than the fundamental frequencies. The great significance of our theory is that it indicates in principle the feasibility to alter or rewrite the information contents of a nerve message in our body by applying stimulations of appropriate strengths and frequencies. Thus, the theory provides a physical basis and hence some understanding for a new branch of medicine—neuro therapy such as Nogier's auriculotherapy, Lamy's phonophoresis, Voll's electroacupuncture and the fast rising TENS (transcutaneous electro-neuro stimulation).
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    Bulletin of mathematical biology 42 (1980), S. 107-117 
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    Notes: Abstract A new physical property, called resonance of the B-type is hypothetically attached to the λ =546 nm irradiated crystalline (small) molecules. In this respect an up or down configuration is assumed for those states obtained through irradiation times that are multiples of 5 sec. With these assumptions, the cellular receptors that may detect these states appear to belong to three classes: the up, down and alternatively mixed up-down. Using the classic formalism of eigenvectors and eigenvalues, a simple spectroscopic type of formula is derived, through which all the possible states of the above characteristic may be obtained.
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    Bulletin of mathematical biology 42 (1980), S. 119-130 
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    Notes: Abstract A model of ecosystems with migration is proposed from the viewpoint of flow. This model explains the following two points: (1) How the density-dependent terms in population dynamics arise as a consequence of migration. (2) How the ecosystem exhibits a hierarchy in energy per unit biomass.
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    Bulletin of mathematical biology 42 (1980), S. 143-145 
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    Bulletin of mathematical biology 42 (1980), S. 95-106 
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    Notes: Abstract For precise boundary conditions of biological relevance, it is proved that the steadily propagating plane-wave solution to the Fisher equation requires the unique (eigenvalue) velocity of advance 2(Df)1/2, whereD is the diffusivity of the mutant species andf is the frequency of selection in favor of the mutant. This rigorous result shows that a so-called “wrong equation”, i.e. one which differs from Fisher's by a term that is seemingly inconsequential for certain initial conditions, cannot be employed readily to obtain approximate solutions to Fisher's, for the two equations will often have qualitatively different manifolds of exact solutions. It is noted that the Fisher equation itself may be inappropriate in certain biological contexts owing to the manifest instability of the lowerconcentration uniform equilibrium state (UES). Depicting the persistence of a mutantdeficient spatial pocket, an exact steady-state solution to the Fisher equation is presented. As an alternative and perhaps more faithful model equation for the propagation of certain species properties through a homogeneous population, we consider a reaction-diffusion equation that features a cubic-polynomial rate expression in the species concentration, with two stable UES and one intermediate unstable UES. This equation admits a remarkably simple exact analytical solution to the steadily propagating plane-wave eigenvalue problem. In the latter solution, the sign of the eigenvelocity is such that the wave propagates to yield the “preferred” stable UES (namely, the one further removed from the unstable intermediate UES) at all spatial points ast→∞. The cubic-polynomial equation also admits an exact steady-state solution for a mutant-deficient or mutant-isolated spatial pocket. Finally, the perpetuating growth of a mutant population from an arbitrary localized initial distribution, a mathematical problem analogous to that for ignition in laminar flame theory, is studied by applying differential inequality analysis, and rigorous sufficient conditions for extinction are derived here.
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    Bulletin of mathematical biology 42 (1980), S. 191-220 
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    Notes: Abstract The binding of mono-, di- and trivalent cations to negatively charged surfaces is studied within the framework of a modified Gouy-Chapman equation. For any given combination of ions of the above valences, the existence and uniqueness of the solution for the surface potential is shown. The treatment provides the surface potential and charge density. For a system containing only monovalent and divalent ions, analytical solutions are given. When trivalent ions are also present, a procedure based on numerical integration is described. The distance dependence of the electrostatic potential for planar surfaces is given. The calculations provide the amount of cations tightly bound and the amount trapped in the double layer region. The competition between cations for binding to surfaces is elucidated.
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    Bulletin of mathematical biology 42 (1980), S. 221-238 
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    Notes: Abstract This paper deals with a model describing the behavior of barium-treatedApalysia neurons. The model is represented by a dynamical system, so-called “complete system”, defined in R4 and depending on a small parameter. The study of this system under zero membrane current conditions was performed with the use of the qualitative theory of singular perturbations. We show that this system has a stable periodic solution of the discontinuous type when the small parameter tends to 0+. A reduced system defined in R3, associated to the complete system was also studied: it corresponds to a constant activation of the inward current. We demonstrate that the corresponding hypothetical cell remains silent under zero current conditions.
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    Notes: Abstract In the study of chemical modification of enzymes and other biologically active proteins, plots of fractional residual activity as a function of number of groups modified per enzyme molecule are often used to establish a correlation between the chemical modification and enzyme inactivation reactions and to determine the stoichiometry of the modification reaction. This paper presents a critical examination of the underlying theoretical framework of such graphs. Whereas these plots are usually presented as linear functions, it is shown here that the general equation describing the relationship between inactivation and modification contains an exponential term; therefore, in the general case, the plot is actually a curve. It is suggested that caution be exercised in the interpretation of such plots and that equations such as those derived in the text be used to fit theoretical curves to the data, in order to maximize the information gained from chemical modification experiments.
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    Bulletin of mathematical biology 42 (1980), S. 257-265 
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    Notes: Abstract This communiction argues that so-called “hermaphroditic” tracer systems, which are neither open nor closed, do not exist physically. The argument is based on the assumption that any observable (possibly nonhomogeneous) macroscopic compartment can be approximated by a compartmentC with a finite number of entry points for the tracer, each associated with an abstract subcompartment ofC. It is shown that the “hermaphroditic” property requires that the mean waiting time be infinite in at least one of the subcompartments, or in a subcompartment elsewhere in the system. A subcompartment with infinite mean waiting time must have some sort of memory, of infinite duration, which knows how long a given particle has been retained, however long that is, and thereby determines its probability of departure. Assuming, as seems likely, that no physical basis exists for such an infinite memory, it follows that “hermaphroditic” systems do not exist.
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    Bulletin of mathematical biology 42 (1980), S. 273-274 
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    Bulletin of mathematical biology 42 (1980), S. 275-275 
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    Bulletin of mathematical biology 42 (1980), S. 277-281 
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    Bulletin of mathematical biology 42 (1980), S. 267-272 
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    Notes: Abstract The implication of state space structure on the existence of a repeatable experimentE designed to determine if a states∈L has propertyP or notP is investigated. It is shown that if a state spaceL is connected, then no experimentE is repeatable. This formalism is used to demonstrate that if a propertyP has an associated set of points inL which is dense with dense complement inL, then there exists no repeatable experimentE which can be used to test whethers has propertyP or notP. Other consequences of this formalization are discussed.
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    Bulletin of mathematical biology 42 (1980), S. 282-282 
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    Bulletin of mathematical biology 42 (1980), S. 283-294 
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    Notes: Abstract It has been shown that the resistance of flow and the wall shear increase with the size of the stenosis but these increases are comparatively small due to non-Newtonian behaviour of the blood indicating the usefulness of its rheological character in the functioning of the diseased arterial circulation.
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    Bulletin of mathematical biology 42 (1980), S. 327-337 
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    Notes: Abstract The modern theory of generalized Hamiltonian systems is used to construct a unified canonical description of the linear Lagrangian biodynamics introduced by Kerner.
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    Bulletin of mathematical biology 42 (1980), S. 305-325 
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    Notes: Abstract The purpose of this paper is to justify an asymptotic method developed for the study of peristaltic transport in a tube of arbitrary cross section. Within the framework of long wave approximation, the three-dimensional nonlinear Navier-Stokes equations are reduced to a sequence of two-dimensional linear boundary value problems of Laplace and biharmonic operators. It is shown that, if a Reynolds number is less than some constant, the solution of the approximate equations is indeed an asymptotic approximation to the exact solution of the problem as the ratio of the maximum radius of the tube to the wave length of the peristaltic motion of the wall tends to zero, and the error estimates are expressed inL 2 norms. Furthermore, under the same condition the exact solution is shown to be unique and stable under arbitrary perturbation of spatially periodic disturbance. Application of the stability condition to peristaltic transport in a tube of circular cross section is given.
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    Bulletin of mathematical biology 42 (1980), S. 295-304 
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    Notes: Abstract A mathematical analysis, including existence and uniqueness, is given for some boundary value problems which model the flow of a fluid-solute mixture in a tube which is placed in an interstitium. The model permits an interchange of fluid and solute across the tube walls.
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    Bulletin of mathematical biology 42 (1980), S. 339-364 
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    Notes: Abstract The vertebrate nervous system has topographic interconnections in many parts, known for example as retinotopy, somatotopy, etc. It is plausible that modifiable synapses play an important role in forming and refining these connections together with the sensory experiences. To elucidate the mechanism of topographic organization, we propose a simple model consisting of two nerve fields connected by modifiable excitatory synapses. The model also includes modifiable inhibitory synapses. The behavior of the model is described by a set of simultaneous non-linear integro-differential equations. By analyzing the equations, we obtain the equilibrium solution of topographic connections. It is also proved that a part of the presynaptic field which is frequently stimulated comes to be mapped on a large area of the postsynaptic field so that it has a good resolution.
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    Bulletin of mathematical biology 42 (1980), S. 691-700 
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    Notes: Abstract The steady-state solution of the equations governing substrate exchange between vascular and extravascular compartments separated by a membrane with finite, symmetrical substrate permeability is presented. Substrate removal from the extravascular compartment by Michaelis-Menten saturation type kinetics with negligible diffusion in the axial and instantaneous diffusion in the transverse directions in both compartments are assumed. It is shown that the solution degenerates into known expressions for special linearized and asymptotic cases. The method of solution is also applied to an extension of the original model incorporating autoregulatory feedback effects upon the process responsible for substrate removal.
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    Bulletin of mathematical biology 42 (1980), S. 729-737 
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    Notes: Abstract Global asymptotic stability and equilibrium coexistence is established in two species Lotka-Volterra-type competition when there are time delays in interspecific interaction terms and the intraspecies competition is stronger than the interspecies competition.
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    Bulletin of mathematical biology 42 (1980), S. 739-746 
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    Notes: Abstract The realized (observed) value of Landau’s dominance hierarchy index is examined. Under a model of constant pairwise dominance probabilities, the observed index is shown to be a strongly consistent estimator of the underlying (true) index. However, a large number of encounters between animals is shown to be required in order to reduce bias and variance to practical levels except when the pairwise dominance probabilities are near one.
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    Bulletin of mathematical biology 42 (1980), S. 747-748 
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    Bulletin of mathematical biology 42 (1980), S. 749-749 
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    Bulletin of mathematical biology 42 (1980), S. 751-763 
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    Notes: Abstract The steady state potassium conductance as a function of measured membrane potential difference (p.d.) ϕ of the squid giant axon is corrected for the effect of accumulation of potassium in the periaxonal space. This correction is made on the assumption that several mathematical models of the axon are valid. These are (i) the McIlroy (1975), McIlroy-Hahn (1978) model of membrane conductanceg i(i=K, Na) which is a detailed model of passive transport of ions across the axonal membrane with the aid of mobile, negatively-charged carriers, (ii) the Adelmanet al. (1973) compartmental model of the periaxonal and external bathing-solution spaces, (iii) the enzymatic theory of nervous conduction due to McIlroy (1970 a, b, c), (iv) the Wien dissociative effect of the axolemmic electric field on the weak membrane buffer proposed by Bass and Moore (1968) as a trigger mechanism in nervous excitation and (v) the model (McIlroy, 1979) of the interfacial double-layer p.d.s. which are assumed to exist at the membrane’s surfaces because of the presence of a fixed surface charge. From the correctedg k (ϕ) curves the values of the double-layer p.d.s. of model (v) are deduced and these are shown to lead to a consistent, physically reasonable solution for the distance (approx. 6.8Å) between the fixed surface charges and for the dissociation constants of these sites in their interactions with the ions of the extra-membrane electrolytes. Assuming that the selectivity coefficint of the potassium conducting system for the squid giant axon is approx. 52 it is deduced that the potassium permeability,P ks , of the periaxonal barrier ≈1.37(±0.5)×10−4 cm sec−1 and the thickness of the periaxonal space ≈451±159Å.
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    Bulletin of mathematical biology 42 (1980), S. 797-805 
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    Notes: Abstract The effects of peripheral layer viscosity on physiological characteristics of blood flow through the artery with mild stenosis have been studied. It has been shown that the resistance to flow and the wall shear decrease as the peripheral layer viscosity decreases.
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    Bulletin of mathematical biology 42 (1980), S. 829-836 
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    Notes: Abstract A study was made of Higgins’ model of glycolysis incorporating molecular diffusion of intermediates, utilizing an earlier conjecture due to Landau. Conditions for the existence of asymptotically stable spatio-temporal periodic solutions are obtained.
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    Mathematical programming 19 (1980), S. 300-312 
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    Keywords: Equilibrium Prices ; Nonconvex Mathematical Programming ; Shadow Prices
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    Notes: Abstract In this paper a definition is proposed for the concept of shadow prices in nonconvex programming. For a nonlinear program with equality and inequality constraints, existence of these prices and bounds for their possible values are obtained under the Mangasarian—Fromowitz regularity condition. Their exact values and some continuity properties are obtained under the more restrictive linear independence regularity condition. A definition of equilibrium prices is also proposed. Under convexity assumptions, all definitions and results coincide with those already known on this subject in convex programming.
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    Mathematical programming 19 (1980), S. 313-327 
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    Keywords: Retrogressing Paths ; Homotopy Method ; Fixed-point Algorithm
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    Notes: Abstract For certain functionsf fromR n toR n , the Eaves—Saigal algorithm computes a path inR n × (0, 1] which converges to a zero off. In this case, it is shown that even whenf is of classC ∞ and has a unique zero, the converging path may retrogress infinitely many times.
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    Mathematical programming 18 (1980), S. 186-196 
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    Keywords: Weber's Problem ; Weiszfeld's Method ; Optimal Location
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    Notes: Abstract For solving the Euclidean distance Weber problem Weiszfeld proposed an iterative method. This method can also be applied to generalized Weber problems in Banach spaces. Examples for generalized Weber problems are: minimal surfaces with obstacles, Fermat's principle in geometrical optics and brachistochrones with obstacles.
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    Mathematical programming 18 (1980), S. 84-88 
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    Keywords: Complementary Pivot Algorithms ; Triangulations ; Vector Labels ; Borsuk's Theorem on Antipodal Points
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    Notes: Abstract In this short note a simple and constructive proof is given for Borsuk's theorem on antipodal points. This is done through a special application of the complementary pivoting algorithm.
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    Mathematical programming 18 (1980), S. 110-110 
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    Mathematical programming 18 (1980), S. 155-168 
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    Keywords: Constrained Optimization ; Differential Equation ; Global Solution ; Nonlinear Programming
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    Notes: Abstract A new method is presented for finding a local optimum of the equality constrained nonlinear programming problem. A nonlinear autonomous system is introduced as the base of the theory instead of usual approaches. The relation between critical points and local optima of the original optimization problem is proved. Asymptotic stability of the critical points is also proved. A numerical algorithm which is capable of finding local optima systematically at the quadratic rate of convergence is developed from a detailed analysis of the nature of trajectories and critical points. Some numerical results are given to show the efficiency of the method.
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    Mathematical programming 18 (1980), S. 215-227 
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    Keywords: Frank—Wolfe Theorem ; Quadratic Programming ; Norm Coercive Functions ; Polyhedral Sets
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    Notes: Abstract The Frank—Wolfe theorem states that a quadratic function, bounded below on a nonempty polyhedral convex set, attains its infimum there. This paper gives sufficient conditions under which a function either attains its infimum on a nonempty polyhedral convex set or is unbounded below on some halfline of that set. Quadratic functions are shown to satisfy these sufficient conditions.
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    Mathematical programming 18 (1980), S. 248-273 
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    Keywords: Legendre Transform ; Stationary Points ; Convex Functions ; Duality
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    Notes: Abstract In this work non-convex programs are analyzed via Legendre transform. The first part includes definitions and the classification of programs that can be handled by the transformation. It is shown that differentiable functions that are represented as a sum of strictly concave and convex functions belong to this class. Conditions under which a function may have such representation are given. Pseudo duality is defined and the pseudo duality theorem for non linear programs with equality constraints is proved. The techniques described are constructive ones, and they enable tocalculate explicitly a pseudo dual once the primal program is given. Several examples are included. In the convex case these techniques enable the explicit calculation of the dual even in cases where direct calculation was not possible.
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    Mathematical programming 18 (1980), S. 286-290 
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    Keywords: Facility Location ; Steiner's Problem ; Location on the Sphere
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    Notes: Abstract This note describes the nature of optimal solutions for the spherical Steiner-Weber location problem for the case of unit weights and either 3 or 4 demand points (requireing 4 demand points to lie in an open hemisphere). Geometrically appealing results which are necessary conditions for optimum solutions and spherical analogs of known planar results are obtained.
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    Mathematical programming 18 (1980), S. 62-67 
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    Keywords: Economic Interpretation ; Mathematical Programming ; Duality ; Stochastic Programming
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    Notes: Abstract The purpose of this note is to interpret a class of stochastic programming problems in economic terms. The primal stochastic program is shown to represent a certain production program of an entrepreneur. The dual program, which is also a stochastic program, represents the problem of a contractor who desires to purchase the entrepreneur's resources and sell product back to him.
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    Mathematical programming 18 (1980), S. 138-145 
    ISSN: 1436-4646
    Keywords: Set-covering Problem ; Branch and Bound ; Lower Bounds ; Steiner Triple Systems
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    Topics: Computer Science , Mathematics
    Notes: Abstract Fulkerson et al. have given two examples of set covering problems that are empirically difficult to solve. They arise from Steiner triple systems and the larger problem, which has a constraint matrix of size 330 × 45 has only recently been solved. In this note, we show that the Steiner triple systems do indeed give rise to a series of problems that are probably hard to solve by implicit enumeration. The main result is that for ann variable problem, branch and bound algorithms using a linear programming relaxation, and/or elimination by dominance require the examination of a super-polynomial number of partial solutions
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    Mathematical programming 18 (1980), S. 228-228 
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    Mathematical programming 18 (1980), S. 232-232 
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    Mathematical programming 18 (1980), S. 308-329 
    ISSN: 1436-4646
    Keywords: Polytopes ; Linear Programming
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    Topics: Computer Science , Mathematics
    Notes: Abstract This paper provides answers to several questions raised by V. Klee regarding the efficacy of Mattheiss' algorithm for finding all vertices of convex polytopes. Several results relating to the expected properties of polytopes are given which indicate thatn-polytopes defined by “large” numbers of constraints are difficult to obtain by random processes, the expected value of the number of vertices of polytope is considerably less than Klee's least upper bound the expected performance of Mattheiss' algorithm is far better than Klee's upper bound would suggest.
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    OR spectrum 1 (1980), S. 143-168 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Die Elemente der Modellierungskonzeption System Dynamics werden beschrieben und anhand von zwei einfachen Lager- und Produktionsplanungsmodellen demonstriert. Nach der Darstellung des Aufbaus eines implementierten System Dynamics Modells wird die Anwendbarkeit dieses Modellierungskonzeptes kritisch analysiert.
    Notes: Summary The fundamentals of the modelling approach System Dynamics are described and illustrated by two simple inventory and production planning models. After discussing the structure of an implemented System Dynamics model the applicability of this modelling approach is critically analysed.
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    OR spectrum 1 (1980), S. 169-181 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary This paper discusses a heuristic algorithm for solving a special scheduling problem: the assignment of a set of ships to a set of routes under specific complex restrictions. The usefulness of the resulting schedule is demonstrated by comparisation with a given schedule for container ships in the Europe — Australia — NewZealand service.
    Notes: Zusammenfassung In der vorliegenden Arbeit wird ein heuristisches Verfahren zur Lösung eines besonderen Reihenfolgeproblems behandelt: die Zuordnung einer Menge von Schiffen zu einer Menge von Routen unter besonderen, komplexen Bedingungen. Die Brauchbarbeit des sich ergebenden Fahrplans wird durch Vergleich mit einem gegebenen Fahrplan für Container-Schiffe im Liniendienst zwischen Europa und Australien/Neuseeland veranschaulicht.
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    OR spectrum 1 (1980), S. 183-198 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary Personnel expense planning is of great importance within big enterprise corporate planning. Orientation points are given from total economic development and from the market. The task is to find out personnel expense depending on personnel figures, work time requirement, etc. by implementation of a general matrix model. Non linear components are includet. The model runs in routine.
    Notes: Zusammenfassung Die Personalaufwandsplanung hat für die Unternehmensplanung eines Großunternehmens besondere Bedeutung. Orientierungspunkte dabei sind die gesamtwirtschaftliche Entwicklung und die Absatzmarktlage. Aufgabe ist die Ermittlung des Personalaufwands in Abhängigkeit von Belegschaftszahlen, Arbeitszeitbedarf usw. mit Hilfe eines allgemeinen Matrizenmodells, das auch nichtlineare Komponenten enthält. Das Modell ist routinemäßig im Einsatz.
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    OR spectrum 1 (1980), S. 209-209 
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    OR spectrum 1 (1980), S. 207-209 
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    OR spectrum 1 (1980), S. 210-210 
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  • 85
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    Description / Table of Contents: Zusammenfassung Diese Arbeit untersucht die Parameter-Abhängigkeit von Ergebnissen kriegerischer Auseinandersetzungen zweier homogener Gegner (insbesondere Vernichtung eingesetzter Kräfte), die mit Gleichungen der Lanchester-Theorie mit zeitabhängigen Verlustraten modelliert werden. Es wurde gezeigt, daß die Vorhersage der Vernichtung von Kräften von sogenannten Paritätsbedingungen nur von Verlustraten abhängen. Neue wichtige Ergebnisse geben Auskunft, wie diese Paritätsbedingungen von der Kampfintensität und der relativen Feuereffektivität der Gegner abhängen. Bisherige analytische Ergebnisse des Autors können Anwendung in einer viel umfangreicheren Art von Verlustraten finden. Diese neuen Ergebnisse erlauben es, daß eine umfangreiche Art von Gleichungen der LanchesterTheorie moderner Kriegsführung mit zeitlicher Feuereffektivitätsveränderung beinahe so leicht untersucht werden können, wie das klassische Modell von Lanchester mit konstanter Verlustrate.
    Notes: Summary This paper studies the parametric dependence of battle outcome (in particular, force annihilation) for combat between two homogeneous forces modelled by Lanchester-type equations of modern warfare with time-dependent attrition-rate coefficients. Force-annihilation prediction has been shown to depend on a so-called parity-condition parameter, which depends on only the attrition-rate coefficients. New important results are given on how the parity-condition parameter depends on the intensity of combat and the relative fire effectiveness of the combatants. Previous analytical results of the author are shown to apply to a much wider class of attrition-rate coefficients. These new results allow a wide class of Lanchester-type equations of modern warfare with temporal variations in fire effectiveness to be studied almost as easily as Lanchester's classic constant-coefficient model.
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    OR spectrum 1 (1980), S. 211-232 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary This article gives an overview on the mathematical methods of cluster analysis. It describes algorithms for constructing homogeneous classes of objects, several criteria for the evaluation of classifications, and some examples of application.
    Notes: Zusammenfassung Dieser Artikel gibt einen Überblick über die mathematischen Methoden der Clusteranalyse. Er berichtet über Algorithmen zur Konstruktion von homogenen Objektklassen, über Verfahren zur Bewertung von Klassifikationen sowie über praktische Anwendungsfälle.
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    OR spectrum 1 (1980), S. 243-249 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary Selected real-world nonlinear programming applications are presented that have arisen in different industries, namely food, electric utility, insurance and engineering. The models belong to the class of all-quadratic programs, that is, a quadratic function is to be minimized subject to quadratic constraints. The problems are solved by means of computer software for the Sequential Unconstrained Minimization Technique (SUMT) and for Geometric Programming.
    Notes: Zusammenfassung Es wird über einige ausgewählte Anwendungen der nichtlinearen Programmierung berichtet, die in unterschiedlichen Wirtschaftszweigen aufgetreten sind, nämlich in der Nahrungsmittelindustrie, in der Energieversorgungswirtschaft, in der Versicherungswirtschaft und im Maschinenbau. Die Modelle gehören der Klasse der ganz-quadratischen Programme an, d.h. eine quadratische Zielfunktion ist zu minimieren unter quadratischen Nebenbedingungen. Die Optimierungsprobleme werden mit Hilfe von Computersoftware für die Sequential Unconstrained Minimization Technique (SUMT) und für die Geometrische Programmierung gelöst.
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    OR spectrum 1 (1980), S. 233-242 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Wir betrachten Markoffsche Entscheidungsprozesse mit endlichem Zustands- und Aktionenräumen für das Kriterium des Durchschnittsertrags. Wir untersuchen die Methode der wertorientierten sukzessiven Approximation, die für das Kriterium des Gesamtertrags von Van Nunen ausführlich untersucht wurde. Unter einer starken Aperiodizitätsbedingung und verschiedenen Voraussetzungen, die eine Unabhängigkeit des optimalen Durchschnittsertrages vom Anfangszustand garantieren, beweisen wir die Konvergenz der Methode.
    Notes: Summary We consider the Markov decision process with finite state and action spaces at the criterion of average reward per unit time. We study the method of value oriented successive approximations, extensively treated by Van Nunen for the total reward case. Under a strong aperiodicity assumption and various conditions which guarantee that the gain of the process is independent of the starting state we show that the method converges and produces nearly optimal policies.
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    OR spectrum 1 (1980), S. 261-264 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary In network applications the problem of sensitivity often is of great practical interest. The aim of this paper is to provide indices of sensitivity for the arcs and vertices of a network, depending on the number of paths running through. In connection with a powerful algorithm for computing these numbers, the indices will be useful for considerations of sensitivity.
    Notes: Zusammenfassung Sensitivitätsbetrachtungen in Netzen sind in vielen praktischen Anwendungsfällen von großem Interesse. In dieser Arbeit werden für die Knoten und Kanten eines Netzes Sensitivitätsindices angegeben, die auf der Anzahl der durch sie verlaufenden Wege des Netzes basieren. Zusammen mit einem leistungsfähigen Algorithmus zur Berechnung dieser Anzahlen stellen diese Indices ein brauchbares Mittel für Sensitivitätsbetrachtungen in Netzen dar.
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    Description / Table of Contents: Summary This contribution describes the solution of an one-dimensional cutting problem in the context of a production control system. The solution of the cutting problem is demonstrated at the example of the production of central heating radiator units. The procedure is subdivided in an initial heuristic phase in order to concentrate the problem description. Afterwards an optimization phase is added to find the best solution of the reduced problem by using Linear Programming. Test results of field experiences are given. The last part of the contribution shows the integration of this solution in the global material and machine planning and control moduls. This is done by the determination of the interfaces of the batch oriented production control system and the process control of an NC saw machine.
    Notes: Zusammenfassung In diesem Beitrag wird am Beispiel der Produktion von Radiator-Heizungskörpern die Lösung des Zuschnittproblems der Vor- und Rücklaufrohre mit einem heuristisch-optimierenden Verfahren dargestellt. Die heuristische Vorschaltphase des Verfahrens ermöglicht bei geschickter Wahl der Kriterien eine Reduktion der Dimension des Verschnittproblems, ohne die Lösungsgüte unzulässig einzuschränken. Im Rahmen der reduzierten Problembeschreibung folgt anschließend die Optimierungsphase durch Anwendung der Linearen Programmierung. Es werden Testergebnisse im praktischen Einsatz des Verfahrens beschrieben. Weiterhin wird die Betrachtung der Integration des Verfahrens in ein globales EDV-gestütztes Produktionsplanungs- und -steuerungssystem behandelt, indem die Schnittstellen in der Material- und Terminbewirtschaftung zwischen dem stapelorientierten Planungskonzept und der Prozeßkontrolle einer NC-Sägeanlage definiert werden.
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    OR spectrum 1 (1980), S. 265-265 
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    OR spectrum 1 (1980), S. 270-270 
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    OR spectrum 1 (1980), S. 271-272 
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    OR spectrum 1 (1980), S. 272-272 
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    OR spectrum 2 (1980), S. 79-89 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung In einer Simulationsstudie werden mehrere hierarchische Methoden zur Produktionsplanung und Lagerhaltung untersucht, die zusammen mit der Materialbedarfsplanung eingesetzt werden können. Die verwendeten Daten stammen aus einem Unternehmen, dessen Endprodukt eine komplexe Struktur besitzt. In dem zunächst gebildeten aggregierten Modell werden alle Teilprodukte zu einer Produktgruppe und alle Maschinen zu einer Maschinengruppe zusammengefaßt. Mit Hilfe verschiedener Lösungsmethoden wurde dieses aggregierte Planungsproblem gelöst. Ausgehend von der Optimallösung des aggregierten Modells wird der detaillierte Produktionsplan in der Weise ermittelt, daß durch Variation der Freigabezeiten und durch Variation der Auftragsgrößen dieser an die Optimallösung möglichst gut angepaßt wird. Unsere Ergebnisse zeigen, daß sehr einfache hierarchische Planungsmethoden signifikante Kostenminderungen verglichen mit einer Materialbedarfsplanung auf der Basis prognostizierter Nachfragen ergeben können.
    Notes: Summary Hierarchical planning methods which can be utilized in connection with material requirements planning have been evaluated in a simulation study. Data have been obtained from a company producing one final product having a complex structure. In the aggregate model all items are aggregated into one product group and all machines into one machine group. Different solution methods have been used for solving the aggregate planning problem. The aggregate plan is disaggregated by adjusting the detailed production plans using two methods involving changes of order release times and changes of order quantities. Our results indicate that also very simple hierarchical planning processes can give significant cost reductions compared to using material requirements planning based on predicted demand.
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    Monatshefte für Mathematik 89 (1980), S. 1-8 
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    Monatshefte für Mathematik 89 (1980), S. 19-44 
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    Topics: Mathematics
    Notes: Abstract A new proof of a theorem of W. Neiss is given that the rays of the Quadratwurzelschnecke are uniformly distributed mod 2 π. The exact order of the discrepancy of the sequence is determined. Multidimensional generalizations of this sequence are also considered. It is shown that the Quadratwurzelschnecke is something like a roulette.
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    Monatshefte für Mathematik 89 (1980), S. 45-56 
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    Topics: Mathematics
    Notes: Abstract We continue our investigations started in a paper with the same title. The γ-length of a curve defined in this paper can be written as an integral along the curve. Furthermore, we determine necessary and sufficient conditions for the existence of a measure of orientated lines which generates a given non-symmetric pseudo-metric.
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    Monatshefte für Mathematik 89 (1980), S. 9-17 
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    Topics: Mathematics
    Notes: Abstract The spaceG B of $$\bar B$$ -orbits of an [FIA] B − groupG is a commutative hypergroup (=commutative convo in Jewett's terminology). Its space of “hypergroup characters” is a hypergroup itself (see [3]) which can be identified withE (G, B) (the extreme points ofB-invariant positive definite continuous functionsp:G→ℂ withp (e)=1), endowed with the topology of compact convergence. We determine the structure space ofL 1 (E(G, B), μ PL ) whereμ PL is the Plancherel measure (which is the “Haar measure” ofE(G, B)) and characterize the convolution algebrasM (E(G, B)) andL 1 (E(G, B)) via the inverse Fourier-Stieltjes transformation.
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