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  • Middle Aged  (17)
  • American Association for the Advancement of Science (AAAS)  (17)
  • American Association of Petroleum Geologists (AAPG)
  • Elsevier
  • Wiley
  • 1990-1994
  • 1975-1979  (17)
  • 1979  (17)
Collection
Publisher
  • American Association for the Advancement of Science (AAAS)  (17)
  • American Association of Petroleum Geologists (AAPG)
  • Elsevier
  • Wiley
Years
  • 1990-1994
  • 1975-1979  (17)
Year
  • 1
    Publication Date: 1979-10-05
    Description: The metabolism of americium-241 has been studied during an 8-year period in an adult male and his son who, at the ages of 50 and 4 years, respectively, were accidentally and unknowingly contaminated within their home by means of inhalation. Chelation therapy with calcium trisodium pentetate was more effective in enhancing the removal of americium-241 from the child than from the father.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, N -- Sasso, T L -- Wrenn, M E -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482925" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Americium/*metabolism/poisoning ; Body Burden ; Body Height ; Body Weight ; Bone and Bones/metabolism ; Chelating Agents/*therapeutic use ; Child, Preschool ; Humans ; Liver/metabolism ; Lung/metabolism ; Male ; Middle Aged
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
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  • 3
    Publication Date: 1979-01-19
    Description: Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Rossier, J -- Bloom, F E -- Guillemin, R -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83674" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*physiology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid/immunology ; Enkephalins/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Radioimmunoassay
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  • 4
    Publication Date: 1979-09-07
    Description: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223241" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Cholesterol/*blood/metabolism ; Diet ; Female ; Humans ; Lipoproteins, HDL/*blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Risk ; Running ; Sex Factors ; Tissue Distribution
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
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  • 8
    Publication Date: 1979-11-09
    Description: Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehr, T A -- Wirz-Justice, A -- Goodwin, F K -- Duncan, W -- Gillin, J C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):710-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227056" target="_blank"〉PubMed〈/a〉
    Keywords: Bipolar Disorder/*physiopathology/therapy ; Body Temperature Regulation ; *Circadian Rhythm ; Female ; Humans ; Middle Aged ; Motor Activity/physiology ; Sleep, REM/*physiology
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  • 9
    Publication Date: 1979-08-24
    Description: Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casper, R F -- Yen, S S -- Wilkes, M M -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462193" target="_blank"〉PubMed〈/a〉
    Keywords: *Climacteric ; Dopamine/blood ; Epinephrine/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood/*secretion ; Middle Aged ; Norepinephrine/blood ; Prolactin/blood
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-04
    Description: Disaturated (fully saturated) lecithins adsorb onto solid surfaces more readily than lecithins in which one or both fatty acids are unsaturated. If saturated lecithins adsorb to arterial walls as they do to glass and polystyrene surfaces, there may be increased probability of atherosclerosis when the disaturated lecithin content of plasma is elevated. Analyses of lecithins in plasma samples from patients with myocardial infarction, and from patients with premature atherosclerosis but with low concentrations of plasma cholesterol and triglycerides, are consistent with the hypothesis that a high concentration of disaturated lecithin in plasma may be a significant risk factor for atherosclerosis, independent of triglyceride and cholesterol concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gershfeld, N L -- New York, N.Y. -- Science. 1979 May 4;204(4392):506-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/581915" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; Adult ; Aged ; Arteriosclerosis/blood/*etiology ; Coronary Disease/*blood ; Fatty Acids, Unsaturated ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; *Phosphatidylcholines/blood ; Pulmonary Surfactants/blood ; Structure-Activity Relationship ; Temperature
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  • 11
    Publication Date: 1979-07-13
    Description: Human erythrocytes have specific insulin receptors. When studied in an insulin radioreceptor assay, erythrocytes from adult-onset, nonobese diabetic subjects bound at least 42 percent less insulin than the normal subjects at insulin concentrations from 0.1 to 100 nanograms per milliliter. The diabetic subjects had 190 insulin receptor sites per cell as compared with the 380 insulin receptor sites per cell for the normal subjects. The deficit of insulin binding in the diabetic subject was thus associated with a fewer number of insulin binding sites per cell with little or no change in affinity. The erythrocyte is a readily available cell for the evaluation of cellular insulin receptor activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, T J -- Archer, J A -- Gambhir, K K -- Hollis, V W Jr -- Carter, L -- Bradley, C -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):200-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451590" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Diabetes Mellitus/*blood/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Female ; Humans ; Insulin/metabolism ; Male ; Middle Aged ; Receptor, Insulin/*metabolism
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-14
    Description: Plasma beta-endorphin-like immunoreactivity was measured by a method that was equally sensitive to beta-endorphin and [Leu5]-beta-endorphin. Immunoreactivity in 98 schizophrenic patients did not differ greatly from that in 42 normal subjects. No immunoreactivity was detectable in dialyzates from first-time hemodialysis of eight nonpsychotic renal patients and nine schizophrenic patients. These results are not compatible with recent reports of extremely high concentrations of [Leu5]-beta-endorphin in hemodialyzates from schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M -- Berger, P A -- Goldstein, A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1163-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472735" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Endorphins/*blood/immunology ; Female ; Humans ; Male ; Middle Aged ; Radioimmunoassay ; Schizophrenia/*blood ; Stress, Physiological/blood
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-16
    Description: Golgi-stained dendrites of single randomly chosen layer-II pyramidal neurons in the human parahippocampal gyrus were quantified with a computer-microscope system. In nondemented aged cases (average age, 79.6 years), dendritic trees were more extensive than in adult cases (average age, 51.2), with most of the difference resulting from increases in the number and average length of terminal segments of the dendritic tree. These results provide morphological evidence for plasticity in the mature and aged human brain. In senile dementia (average age, 76.0), dendritic trees were less extensive than in adult brains, largely because their terminal segments were fewer and shorter. Cells with shrunken dendritic trees were found in all brains. These data suggest a model of aging in the central nervous system in which one population of neurons dies and regresses and the other survives and grows. The latter appears to be the dominant population in aging without dementia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buell, S J -- Coleman, P D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):854-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493989" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Cells, Cultured ; Dementia/pathology/*physiopathology ; Dendrites/pathology/physiology/ultrastructure ; Hippocampus/pathology ; Humans ; Middle Aged
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-04
    Description: The time for the long-term clearance of dust from human lungs was measured. Three heavy cigarette smokers and nine nonsmokers inhaled a harmless trace amount of magnetic dust, Fe3O4. From periodic measurements with a sensitive magnetic detector of the amount of this dust remaining in the lungs, a clearance curve was determined for each subject. This magnetic tracer method allows clearance to be safely followed for a much longer time than with radioactive tracer methods. The dust clearance in the smokers is considerably slower than in the nonsmokers. After about a year, 50 percent of the dust originally deposited remained in the lungs of the smokers whereas only 10 percent remained in the lungs of the nonsmokers. The smokers therefore retained five times more dust than the nonsmokers. This impaired clearance of Fe3O4 suggests impaired clearance in smokers of other dusts, such as toxic occupational and urban dusts. The higher retention of these dusts may contribute to the higher incidence of lung diseases in smokers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, D -- Arai, S F -- Brain, J D -- New York, N.Y. -- Science. 1979 May 4;204(4392):514-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432655" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Dust ; Humans ; Iron ; Lung/*physiopathology ; Lung Compliance ; Magnetics ; Male ; Middle Aged ; Smoking/*physiopathology
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  • 15
    Publication Date: 1979-12-07
    Description: Concentrations of dopamine-related tetrahydroisoquinolines (salsolinol and O-methylated salsolinol) were significantly higher in the daily urine samples of alcoholic subjects admitted for alcohol detoxification than in the daily urine samples of nonalcoholic control subjects. Salsolinol concentrations in alcoholic subjects appeared to drop to trace (control) values 2 to 3 days after admission, following the disappearance of ethanol and its reactive metabolite acetaldehyde from the blood. These results indicate that physiologically active tetrahydroisoquinolines increase in humans during long-term alcohol consumption, presumably because of acetaldehyde's direct condensation with catecholamines. The presence of these or similar condensation products in the urine could be useful as clinical indicators of prior blood acetaldehyde concentrations in chronic alcoholics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, M A -- Nijm, W P -- Borge, G F -- Teas, G -- Goldfarb, C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1184-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505002" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/blood ; Adult ; Alcoholism/metabolism/*urine ; Dopamine/*metabolism ; Humans ; Isoquinolines/*urine ; Male ; Middle Aged ; Salsoline Alkaloids/urine ; Substance Withdrawal Syndrome/urine
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-20
    Description: Absolute amounts of cadmium (in milligrams) in the left kidney and concentrations of cadmium (micrograms per gram) in the liver were measured in vivo in 20 healthy adult male volunteers. Organ cadmium levels of smokers were significantly elevated above those of nonsmokers. No relationship was evident between body stores of cadmium (liver and kidney) and cadmium or beta 2-microglobulin in urine or blood. The average total body burden of cadmium in man at age 50 is estimated to be 19.3 milligrams for nonsmokers and 35.5 milligrams for smokers (38.7 pack-year smoking history). Biological half-time for the whole body was, on average, 15.7 years (10- to 33-year range). Dietary absorption was 2.7 micrograms per day. Cigarette smoking resulted in the absorption of 1.9 micrograms per pack.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ellis, K J -- Vartsky, D -- Zanzi, I -- Cohn, S H -- Yasumura, S -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377488" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cadmium/*analysis ; Diet ; Humans ; Kidney/analysis ; Liver/analysis ; Male ; Middle Aged ; Neutron Activation Analysis ; Smoking/*physiopathology ; Tissue Distribution ; beta 2-Microglobulin/urine
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  • 17
    Publication Date: 1979-11-02
    Description: Serum samples from 158 West Africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. Antibodies specific for Plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. More than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nardin, E H -- Nussenzweig, R S -- McGregor, I A -- Bryan, J H -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):597-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386511" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Antibodies/*analysis ; Child ; Child, Preschool ; Disease Reservoirs/immunology ; Fluorescent Antibody Technique ; Humans ; Malaria/*immunology ; Middle Aged ; Plasmodium falciparum/*immunology ; Vaccines
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