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  • AERODYNAMICS  (471)
  • Animals  (374)
  • 2000-2004
  • 1980-1984
  • 1975-1979  (845)
  • 1925-1929
  • 1979  (845)
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  • 2000-2004
  • 1980-1984
  • 1975-1979  (845)
  • 1925-1929
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  • 101
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-02
    Description: Conditional methods are proposed for investigating the number and relationships of processes that are rate-limiting for the genesis of consecutive stages in a developmental sequence. These methods depend on the differential sensitivity of "timer" pathways to small changes in temperature and can be applied to any developmental sequence in which discrete stages can be reproducibly monitored with time. We have applied the methods to multicellular morphogenesis in the slime mold Dictyostelium discoideum and have obtained an unexpected tentative scheme for timer relationships. A minimum of six timers has been delineated, each specific for at least one morphological stage. The majority of these timers appear to be in parallel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soll, D R -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):841-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419408" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Clocks ; Cell Adhesion ; Cell Differentiation ; Dictyostelium/*cytology ; Embryo, Nonmammalian/*physiology ; *Models, Biological ; Morphogenesis ; Temperature
    Print ISSN: 0036-8075
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  • 102
    Publication Date: 1979-06-29
    Description: The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, J W -- Parker, J B -- Haussler, M R -- Boass, A -- Toverud, S V -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451573" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/blood ; Dihydroxycholecalciferols/*blood ; Female ; Hydroxycholecalciferols/*blood ; *Lactation ; Parathyroid Glands/physiology ; Parathyroid Hormone/physiology ; Phosphorus/blood ; Pregnancy ; *Pregnancy, Animal ; Rats
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  • 103
    Publication Date: 1979-12-07
    Description: After mature rats that had been fed on a vitamin D3-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D3, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, and colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hairshafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D3 or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D3 metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stumpf, W E -- Sar, M -- Reid, F A -- Tanaka, Y -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Digestive System/*metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Intestinal Mucosa/metabolism ; Kidney/*metabolism ; Male ; Parathyroid Glands/*metabolism ; Pituitary Gland/*metabolism ; Rats ; Skin/*metabolism ; Stomach/metabolism
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  • 104
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-01-19
    Description: Human speech and animal sounds contain phonemes with prominent and meaningful harmonics. The biosonar signals of the mustache bat also contain up to four harmonics, and each consists of a long constant-frequency component followed by a short frequency-modulated component. Neurons have been found in a large cluster within auditory cortex of this bat whose responses are facilitated by combinations of two or more harmonically related tones. Moreover, the best frequencies for excitation of these neurons are closely associated with the constant-frequency components of the biosonar signals. The properties of these neurons make them well suited for identifying the signals produced by other echolocating mustache bats. They also show how meaningful components of sound are assembled by neural circuits in the central nervous system and suggest a method by which sounds with important harmonics (or formants) may be detected and recognized by the brain in other species, including humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suga, N -- O'Neill, W E -- Manabe, T -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760193" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Auditory Cortex/cytology/*physiology ; Auditory Pathways/physiology ; Auditory Perception/*physiology ; Chiroptera/*physiology ; Echolocation/physiology ; Neurons/physiology ; Time Factors
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  • 105
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-19
    Description: In echolocating bats, the primary cue for determining distance to a target is the interval between an emitted orientation sound and its echo. Whereas frequency is represented by place in the bat cochlea, no anatomical location represents of primary range. Target range is coded by the time interval between grouped discharges of primary auditory neurons in response to both the emitted sound and its echo. In the frequency-modulated-signal processing area of the auditory cortex of the mustache bat (Pteronotus parnellii rubiginosus), neurons respond poorly or not at all to synthesized orientation sounds or echoes alone but respond vigorously to echoes following the emitted sound with a specific delay from targets at a specific range. These range-tuned neurons are systemically arranged along the rostrocaudal axis of the frequency-modulated-signal processing area according to the delays to which they best respond, and thus represent target range in terms of cortical organization. The frequency-modulated-signal processing area therefore shows odotopic representation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suga, N -- O'Neill, W E -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):351-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Cortex/physiology ; Auditory Threshold ; Behavior, Animal/physiology ; Chiroptera/*physiology ; *Echolocation ; Evoked Potentials ; Neurons/physiology ; *Orientation
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  • 106
    Publication Date: 1979-03-30
    Description: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
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  • 107
    Publication Date: 1979-04-20
    Description: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweeny, G D -- Jones, K G -- Cole, F M -- Basford, D -- Krestynski, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):332-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dioxins/*toxicity ; Enzyme Induction ; Iron/*deficiency ; Liver/pathology ; Mice ; Microsomes, Liver/enzymology ; Mixed Function Oxygenases/metabolism ; Porphyrias/*chemically induced ; Tetrachlorodibenzodioxin/*toxicity ; Uroporphyrinogen Decarboxylase/metabolism
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  • 108
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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  • 109
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
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  • 110
    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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  • 111
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-27
    Description: The body distribution of gavaged or intravenously administered nitrate labeled with nitrogen-13 was studied in humans and rats with the following results: (i) the labeled compound is not quickly absorbed from the stomach; (ii) the concentration of the label increases inside the lower intestinal tract (cercum and large intestine) when ingested or intravenously injected; and (iii) humans and rats have the capacity to store a portion of the label in their bodies. These observation indicate that depletion of body stores, the passage of nitrate down the gut, or the secretion of nitrate into the intestinal lumen may be a better explanation of the urinary, ileal, and fecal concentrations of nitrate and nitrite recently measured in humans that a bacterial nitrification reaction in the intestines, as suggested by Tannenbbaum et al.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Witter, J P -- Gatley, S J -- Balish, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441728" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestines/metabolism ; Nitrates/blood/*metabolism ; Nitrites/metabolism ; *Nitrogen Radioisotopes ; Rats ; Tissue Distribution
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  • 112
    Publication Date: 1979-04-20
    Description: A study was made of the function of the intervening sequences in the ovalbumin gene, Radioactively labeled DNA probes for the intervening sequences were prepared and RNA's were isolated from whole cells, nuclei, and polysomes of estrogen-stimulated chick oviducts. The concentrations of messenger RNA (mRNA) transcripts from ovalbumin structural sequences (mRNAov) and transcripts corresponding to intervening sequences were then estimated by hybridization to cloned DNA probes. Oviduct tissue contains approximately 58,000 molecules of mRNAov sequences per tubular gland cell and most of these sequences are present in the cytoplasm. In contrast, there are 200 to 300 molecules of RNA per cell which are transcribed from the intervening sequences of the natural ovalbumin gene and almost all of these are found in the nucleus. The difference in distribution of structural and intervening sequence transcripts suggests that, unlike mature mRNA, the intervening sequences are not preferentially transported to cytoplasmic polysomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsai, M J -- Tsai, S Y -- O'Malley, B W -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Cell Nucleus/metabolism ; Chickens ; Cytoplasm/metabolism ; *Genes ; In Vitro Techniques ; Nucleic Acid Precursors/*genetics/metabolism ; Ovalbumin/*genetics ; Oviducts ; Polyribosomes/metabolism ; RNA, Messenger/*genetics ; *Transcription, Genetic
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  • 113
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-30
    Description: Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yotti, L P -- Chang, C C -- Trosko, J E -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication/*drug effects ; Cell Membrane/drug effects ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Resistance ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/pharmacology ; Thioguanine/pharmacology
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  • 114
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-07
    Description: Research on pigeon homing suggests that magnetic field information is used for orientation. The ability of pigeons to sense magnetic fields may be associated with a small, unilateral structure between the brain and the skull which contains magnetic in what appears to be single domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walcott, C -- Gould, J L -- Kirschvink, J L -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1027-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472725" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/physiology ; Columbidae/*physiology ; Head/physiology ; *Magnetics ; Orientation/*physiology
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  • 115
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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  • 116
    Publication Date: 1979-04-13
    Description: The anterior cingulate cortex receives thalamic afferents mainly from the midline and intralaminar nuclei rather than the anterior thalamic nuclei. In contrast, the posterior cingulate cortex receives afferents primarily from the anterior thalamic nuclei and from extensive cortical areas in the frontal, parietal, and temporal lobes. These contrasting afferents may provide a structural basis for pain-related functions of the anterior cingulate cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, B A -- Rosene, D L -- Pandya, D N -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107587" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/cytology ; Animals ; Brain Mapping ; Cerebral Cortex/*cytology ; Gyrus Cinguli/*cytology/physiology ; Haplorhini ; Horseradish Peroxidase ; Macaca mulatta ; Thalamic Nuclei/*cytology
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  • 117
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wedeen, R P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):725-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drinking Behavior/*drug effects ; Lead Poisoning/*physiopathology ; Lithium/*pharmacology ; Rats ; Water-Electrolyte Balance/drug effects
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  • 118
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, H L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):696-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462176" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminobutyrate Transaminase/*blood ; Animals ; Blood Platelets/*enzymology ; Brain/enzymology ; Dogs ; Enzyme Activation/drug effects ; Humans ; Kinetics ; Pyridoxal Phosphate/pharmacology ; Rats ; Substrate Specificity ; Transaminases/*blood ; gamma-Aminobutyric Acid/blood
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  • 119
    Publication Date: 1979-10-26
    Description: A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- Farb, D H -- Leeman, S E -- Jessell, T M -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):481-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capsaicin/*pharmacology ; Fatty Acids, Unsaturated/*pharmacology ; Hot Temperature ; Injections, Spinal ; Movement/drug effects ; Nociceptors/drug effects ; Pain/*physiopathology ; Rats ; Spinal Cord/*metabolism ; Substance P/administration & dosage/*metabolism ; Synaptic Transmission/drug effects
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  • 120
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-20
    Description: Male rats consumed a diet containing 0, 12, or 48 percent sucrose on days 16 to 30 of life. Thereafter, they had simultaneous access to all three diets until day 63. No relationship was detected between sucrose consumption early in life and subsequent preference for sucrose. The onset of puberty was associated with a decreased appetite for sucrose among animals of both sexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wurtman, J J -- Wurtman, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Dietary Carbohydrates ; Food Preferences/*drug effects ; Male ; Rats ; Saccharin ; Sexual Maturation ; Sucrose/*pharmacology ; Taste
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  • 121
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, S N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):834.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents ; Brain Chemistry/*drug effects ; Choline/pharmacology ; Rats ; Tryptophan/*pharmacology
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  • 122
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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  • 123
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-22
    Description: Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yen, A -- Pardee, A B -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Division ; Cell Nucleus/physiology/*ultrastructure ; Cells, Cultured/*physiology/ultrastructure ; Clone Cells/ultrastructure ; DNA/biosynthesis ; Mice
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  • 124
    Publication Date: 1979-01-26
    Description: Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zatz, M -- Brownstein, M J -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/32619" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/metabolism ; Animals ; Biological Clocks/drug effects ; Carbachol/administration & dosage/*pharmacology ; Circadian Rhythm/*drug effects/radiation effects ; Injections, Intraventricular ; *Light ; Male ; Neurotransmitter Agents/pharmacology ; Pineal Gland/enzymology/*physiology ; Rats ; Serotonin
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  • 125
    Publication Date: 1979-05-25
    Description: Monkeys of four species were trained to discriminate between sets of natural tonal calls of Japanese macaques (Macaca fuscata) by the position of a frequency-inflection peak or by initial pitch. The Japanese macaques consistently performed best on peak position and the other species on pitch. The results imply special strategies for perceptional processing of vocal sounds and suggest parallels with human speech perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoloth, S R -- Petersen, M R -- Beecher, M D -- Green, S -- Marler, P -- Moody, D B -- Stebbins, W -- New York, N.Y. -- Science. 1979 May 25;204(4395):870-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/108805" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Species Specificity ; Speech Perception/*physiology ; Vocalization, Animal/*physiology
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  • 126
    Publication Date: 1979-08-24
    Description: Persistent light-induced depolarization results from Ca2+ influx across a photoreceptor membrane. The marked dependence on potential of this Ca2+ influx and a Ca+-dependent K+ efflux accounts for enhancement of the light-induced depolarization when light is paired with rotation. A positive feedback cycle between light-induced depolarization and synaptic depolarization due to stimulus pairing can explain long-lasting behavioral changes produced by associative training but not control paradigms. The sensitivity of this Ca2+ influx to intracellular levels of adenosine 3'-5'-monophosphate suggests biochemical steps for this model of associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alkon, D L -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):810-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning/*physiology ; Calcium/*metabolism ; Cyclic AMP/pharmacology ; Electrophysiology ; Iontophoresis ; Learning/*physiology ; Membrane Potentials ; Mollusca/*physiology ; Photic Stimulation ; Photoreceptor Cells/*physiology ; Potassium/*metabolism ; Rotation ; Tetraethylammonium Compounds/pharmacology
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  • 127
    Publication Date: 1979-09-14
    Description: Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alving, C R -- Schneider, I -- Swartz, G M Jr -- Steck, E A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ceramides/therapeutic use ; Erythrocytes/parasitology ; Glycolipids/*therapeutic use ; Liposomes/therapeutic use ; Liver/parasitology ; Malaria/parasitology/*therapy ; Mice ; Plasmodium berghei ; Structure-Activity Relationship
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  • 128
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 16;203(4381):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens/administration & dosage ; Dose-Response Relationship, Drug ; Mice ; Mutagens ; Neoplasms, Experimental/chemically induced ; Rats ; Vinyl Chloride/*toxicity ; Vinyl Compounds/*toxicity
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  • 129
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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  • 130
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-29
    Description: A domestic dog residing in New England suffered a fatal febrile illness caused by a Babesia infection. The morphology of these intraerythrocytic protozoa and the range of hosts that could be infected experimentally suggested that the parasite was B. gibsoni. Although this tick-bourne disease is enzootic in wild and domestic Canidae in Africa and Asia, it appears to be new to the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J F -- Magnarelli, L A -- Donner, C S -- Spielman, A -- Piesman, J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropod Vectors ; Babesia/classification/cytology ; Babesiosis/epidemiology/*parasitology/transmission ; Cricetinae ; Dog Diseases/*parasitology ; Dogs ; Erythrocytes/parasitology ; Mice ; United States
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  • 131
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beary, J F 3rd -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1260.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cetacea/*metabolism ; Meat/*analysis ; Organomercury Compounds/*analysis ; Whales/*metabolism
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  • 132
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-03
    Description: The contrast sensitivity of the rhesus monkey was tested, according to a modified reaction-time paradigm, for sine-wave grating targets at different orientations. The monkey possesses an oblique effect slightly larger than that of humans. A reaction time analysis showed the oblique effect to be a suprathreshold as well as a threshold phenomenon. The presence of this effect further strengthens the use of the monkey as a model for the human visual system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boltz, R L -- Harwerth, R S -- Smith, E L 3rd -- R01 EY001139/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Haplorhini ; Humans ; Macaca mulatta ; Species Specificity ; *Visual Perception
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  • 133
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-02
    Description: Displaced retinal ganglion cells in birds are the sole source of the retinal projection onto the nucleus of the basal optic root, the main component of the accessory optic system. This nucleus has direct bilateral axonal projections onto the oculomotor nuclear complex, the trochlear nucleus- and folia IXc,d and paraflocculus of the vestibulocerebellum. The cerebellar projection terminates within a superficial band of the granule cell layer adjacent to the Purkinje cell layer as a mossy fiber system. This bisynaptic projection onto oculomotor neurons and the cerebellum may play a functionally distinct and specific role in oculomotor reflexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brecha, N -- Karten, H J -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):913-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/570303" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebellum/*cytology ; Columbidae ; Mesencephalon/*cytology ; Oculomotor Nerve/cytology ; Reflex/physiology ; Retina/cytology ; Vestibular Nuclei/cytology ; Visual Pathways/*cytology
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  • 134
    Publication Date: 1979-03-23
    Description: Morphological, karyological, and allozyme analyses indicate that the parthenogenetic lizards Cnemidophorus neomexicanus and diploid C. tesselatus are hybrids formed, respectively, by crosses involving the bisexual species C. tigris and C. inornatus, and C. tigris and C. septemvittatus. Mitochondrial DNA, which is inherited maternally, was obtained from each of these species. Analyses of the mitochondrial DNA's and their restriction endonuclease digestion products by electron microscopy and agarose gel electrophoresis support the hybridization hypothesis by indicating that C. tigris (specifically the subspecies marmoratus) was the maternal parent species for both C. neomexicanus and C. tesselatus. Furthermore, these data imply that these two parthenogenetic species are younger than some races of C. tigris.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, W M -- Wright, J W -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424751" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA Restriction Enzymes/metabolism ; DNA, Mitochondrial/*genetics ; Lizards/*genetics ; *Parthenogenesis ; Reproduction ; Species Specificity
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  • 135
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
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  • 136
    Publication Date: 1979-02-09
    Description: The diffusion of horseradish peroxidase was restricted to layers I and II of the striate cortex in Tupaia glis and Galago senegalensis. In the lateral geniculate body of Tupaia labeled cells were found only in layer 3; some labeled cells were also found in the lateral nucleus. In Galago labeled cells were found only in layers 4 and 5 of the lateral geniculate body; a band of cells was also found in the pulvinar nucleus. These results support the distinction between two overlapping thalamic systems, a layer I and a layer IV system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carey, R G -- Fitzpatrick, D -- Diamond, I T -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):556-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Galago ; Geniculate Bodies/*cytology ; Horseradish Peroxidase ; Neural Pathways/cytology ; Tupaiidae ; Visual Cortex/*cytology
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  • 137
    Publication Date: 1979-07-27
    Description: Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carew, T -- Castellucci, V F -- Kandel, E R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/*physiology ; Electric Stimulation ; *Habituation, Psychophysiologic ; Learning ; Synapses/*physiology
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  • 138
    Publication Date: 1979-04-20
    Description: Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caruso, T P -- Takemori, A E -- Larson, D L -- Portoghese, P S -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86208" target="_blank"〉PubMed〈/a〉
    Keywords: *Alkylating Agents ; Animals ; Chlorambucil/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Guinea Pigs ; Hydromorphone/*analogs & derivatives ; In Vitro Techniques ; Morphine/pharmacology ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives/pharmacology ; Nitrogen Mustard Compounds/*pharmacology ; Norepinephrine/pharmacology ; Oxymorphone/*analogs & derivatives/pharmacology ; Phenoxybenzamine/pharmacology ; Receptors, Opioid/*drug effects
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  • 139
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-02
    Description: Increasing numbers of anthropological studies about native Amazonian warfare and demographic practices attempt to explain these phenomena as competition over or a response to scarce game animals and other sources of high-quality protein. Recently completed field research among the Yanomamo Indians living at the Venezuela-Brazil border indicates that their protein intake is comparable to that found in highly developed industrialized nations and as much as 200 percent more than many nutritional authorities recommend as daily allowances. Recent data on other Amazonian tribes likewise fails to indicate a correlation between protein intake and intensity of warfare patterns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chagnon, N A -- Hames, R B -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):910-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/570302" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild ; Behavior/physiology ; Brazil ; Dietary Proteins/*metabolism ; Energy Intake ; Fishes ; Humans ; *Indians, South American ; Meat ; Warfare
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  • 140
    Publication Date: 1979-03-02
    Description: The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H W -- Israel, M A -- Garon, C F -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):887-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217088" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Coliphages/*genetics ; DNA Restriction Enzymes/metabolism ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; Polyomavirus/*genetics ; Risk ; Tumor Virus Infections/*genetics ; Virus Replication
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  • 141
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-27
    Description: In the abdominal ganglion of Aplysia, a burst of action potentials in peptide-secreting neuroendocrine cells, the bag cells, produces slow inhibition of two identified bursting pacemaker neurons. The inhibition is due to slow hyperpolarizing potential that reduces bursting pacemaker activity for 3 hours or more. The slow inhibitory potential results from a large and prolonged increase in membrane conductance to potassium ions as well as a slower ionic process that is relatively independent of membrane conductance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, P -- Mayeri, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):417-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35827" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Aplysia/*physiology ; Electric Conductivity ; Electric Stimulation ; Female ; Ganglia/physiology ; *Neural Inhibition ; Neurosecretory Systems/*physiology ; Neurotransmitter Agents/physiology ; Oviposition ; Peptides/physiology
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  • 142
    Publication Date: 1979-08-17
    Description: Adult Drosophila were fed with tritium labeled deoxyglucose prior to a 5-hour period of visual stimulation. A flickering disk of light and a moving grating were presented to the left and right eyes, respectively. Autoradiography revealed enhanced labeling solely in that part of the second optic ganglion (medulla) whose visual field was stimulated by movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchner, E -- Buchner, S -- Hengstenberg, R -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):687-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Drosophila melanogaster/anatomy & histology/*physiology ; Female ; Ganglia/metabolism ; Motion Perception/*physiology ; Neurons/*metabolism ; Visual Pathways/metabolism ; Visual Perception/physiology
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  • 143
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-21
    Description: Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elias, E -- Boyer, J L -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574316" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Chlorpromazine/*analogs & derivatives/*pharmacology ; Cytoskeleton/drug effects ; Dose-Response Relationship, Drug ; Gels ; Protein Binding/drug effects ; Rabbits ; Viscosity
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  • 144
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-22
    Description: The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, T K -- Lester, G E -- Lorenc, R S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dihydroxycholecalciferols/biosynthesis ; Female ; Fetal Blood/metabolism ; Hydroxycholecalciferols/*metabolism ; Hydroxylation ; Kidney/embryology/metabolism ; *Nephrectomy ; Placenta/metabolism ; Pregnancy ; *Pregnancy, Animal
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  • 145
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guntheroth, W G -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1040-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472729" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo ; Hemodynamics ; Respiration ; Sleep/*physiology ; Sudden Infant Death/physiopathology
    Print ISSN: 0036-8075
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  • 146
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-20
    Description: The opiate antagonist naloxone has been used to treat shock following acute blood loss in conscious rats. Naloxone treatment rapidly increased mean arterial pressure and pulse pressure in this new shock model. More importantly, these blood pressure changes were sustained and survival was significantly increased with maloxone as compared with placebo treatment. From these findings, it may be inferred that endorphins may play a role in the pathophysiology of hypovolemic shock. It is suggested that narcotic antagonists may prove to be of therapeutic value in the treatment of shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faden, A I -- Holaday, J W -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):317-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure ; Hypotension/drug therapy ; Male ; Naloxone/*therapeutic use ; Rats ; Shock/*drug therapy/physiopathology
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  • 147
    Publication Date: 1979-04-27
    Description: Isografts of Callyspongia diffusa fuse compatibly, but allografts are invariably incompatible. Extensive polymorphism of cell-surface histocompatibility markers is evident. The histocompatibility barriers range from strong to weak depending on the interclonal combination, but early rejection with conspicous cytotoxic sequelae is typical. Reaction times of first-set, second-set, and third-party grafts indicate highly discriminating transplantation immunity with a specific memory component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hildemann, W H -- Johnson, I S -- Jokiel, P L -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):420-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441730" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Histocompatibility Antigens ; Humans ; Immunologic Memory ; Porifera/*immunology ; *Transplantation Immunology
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  • 148
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):522-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/366748" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Electrons ; Electrophysiology ; Free Radicals ; History, 20th Century ; Humans ; Hungary ; Massachusetts ; Neoplasms/*physiopathology ; Pyruvaldehyde/metabolism ; Research Support as Topic
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  • 149
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Findley, J S -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):434-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441733" target="_blank"〉PubMed〈/a〉
    Keywords: Amphibians/anatomy & histology ; Animals ; Anura ; Biological Evolution ; Classification/*methods ; Genotype ; Humans ; Phenotype ; Primates/anatomy & histology
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  • 150
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
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  • 151
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-15
    Description: When fluid secretion by the pancreas was mechanically blocked, amylase secretion into the duct ceased. When flow was reduced in a graded fashion by the application of a back pressure, amylase output was reduced proportionately and amylase concentration in secretion was maintained constant. Thus, the secretion of digestive enzyme from the cell into the duct appears to be dependent upon the concentration of enzyme in the duct system. This behavior is most simply explained by diffusion-like (concentration dependent, bidirectional) fluxes of digestive enzyme across the plasma membrane. A unidirectional process, such as exocytosis, whose rate should be unaffected by fluid flow, cannot readily explain these results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isenman, L D -- Rothman, S S -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1212-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451566" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*secretion ; Animals ; Biological Transport ; Diffusion ; Exocytosis ; Hydrostatic Pressure ; Kinetics ; Pancreas/*secretion ; Rabbits ; Water-Electrolyte Balance
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  • 152
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-05
    Description: Low concentrations of lead, mercury, or cadmium depress the amplitude of the rod receptor potential in the perfused bullfrog retina. Responses from the cones were not affected. The data implicate the rods as a lesion site in animals exhibiting scotopic vision deficits as a result of heavy metal poisoning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, D A -- Sillman, A J -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):78-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/314667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Cadmium/*pharmacology ; Cations, Divalent ; Evoked Potentials/drug effects ; In Vitro Techniques ; Lead/*pharmacology ; Mercury/*pharmacology ; Photoreceptor Cells/*drug effects/physiology ; Rana catesbeiana
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  • 153
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-11
    Description: By using 4.45-angstrom radiation generated by Cl+15 ions in a laser plasma and nanosecond exposures, low-angle x-ray diffraction patterns were obtained from dried rat spinal nerves and a powder of cholesterol. Three to four 400-picosecond, 45-joule pulses were required for the exposure. This new technique should have wide application in structural kinetic studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, R D -- Forsyth, J M -- New York, N.Y. -- Science. 1979 May 11;204(4393):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432665" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cholesterol ; In Vitro Techniques ; *Lasers ; Neurons/*ultrastructure ; Rats ; Time Factors ; X-Ray Diffraction/*methods
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  • 154
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
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  • 155
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-12
    Description: Exposure of the head to pulse-modulated microwaves induces the perception of a sound. It has been hypothesized that the electromagnetic energy is converted to acoustic energy in the skull and then conducted through the bone. Dynamic time-averaged interferometric holography showed that the predicted motion of head tissue did not occur. An alternative locus for this hearing effect is suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, A H -- Coren, E -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):232-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482939" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Bone and Bones/radiation effects ; Cochlea/physiology/radiation effects ; Guinea Pigs ; Hearing/*physiology ; Holography ; Humans ; *Microwaves ; Models, Biological ; Motion ; Rats ; Vibration
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  • 156
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-28
    Description: Field studies, a rearing and maintenance program, and a transfer experiment have shown that anomalous male traits found in some female Ilyanassa obsoleta are an expression of environmentally controlled psuedohermaphroditism. The particular pattern of pseudohermaphroditism discovered in this species has not been reported previously from any other group, but may be characteristic of the Neogastropoda.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenner, M G -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/pathology/*physiopathology ; Female ; Male ; Sex Differentiation ; Snails/growth & development/*physiology
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  • 157
    Publication Date: 1979-08-17
    Description: Discharges of Purkinje cells were recorded from the vermis, lobules VI and VII, of a monkey trained to track a visual target. When the monkey tracked a sinusoidally oscillating target, cellular activity changes in phase with the velocity signal of the eye movement. When the monkey fixated a stationary point, almost identical modulation in activity occurred, reflecting the velocity signal of the motion of the retinal image of the target. The data suggest that the vermis participates in the control of smooth pursuit eye movements by providing the oculomotor system with the actual target velocity information which is the sum of eye velocity and retinal image velocity signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kase, M -- Noda, H -- Suzuki, D A -- Miller, D C -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):717-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111350" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Eye Movements ; Haplorhini ; Motion Perception/physiology ; Proprioception ; Purkinje Cells/*physiology ; Visual Perception/*physiology
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  • 158
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-04
    Description: Compact bovine bone subjected to constant torsional load for long periods of time exhibits large anelastic effects. Displacements occur at the cement lines and are responsible for part or all of the long-term deformation. The absence of an asymptotic creep strain is consistent with an interpretation of the cement line as a viscous interface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lakes, R -- Saha, S -- New York, N.Y. -- Science. 1979 May 4;204(4392):501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Bone and Bones/*physiology ; Cattle ; Compliance ; Stress, Mechanical ; Viscosity
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  • 159
    Publication Date: 1979-05-25
    Description: Recessive mutant gene c in axolotl embryos results in an absence of heart function. Normal (+/+) anterior endoderm cultured with mutant (c/c) hearts totally corrects the defect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemanski, L F -- Paulson, D J -- Hill, C S -- New York, N.Y. -- Science. 1979 May 25;204(4395):860-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441740" target="_blank"〉PubMed〈/a〉
    Keywords: Ambystoma/*embryology/genetics ; Animals ; Culture Techniques ; Embryonic Induction ; Endoderm/physiology ; Genes, Recessive ; Heart/*embryology ; Mutation ; Myocardium/ultrastructure
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  • 160
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-05
    Description: Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewiston, N -- Newman, A -- Robin, E -- Holtzman, D -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):75-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482928" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Animals ; Mitochondria, Heart/*metabolism ; Mitochondria, Liver/metabolism ; *Osmolar Concentration ; *Oxygen Consumption ; Rats ; Sharks/*metabolism ; Species Specificity
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  • 161
    Publication Date: 1979-12-21
    Description: Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Like, A A -- Rossini, A A -- Guberski, D L -- Appel, M C -- Williams, R M -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/388619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/*therapeutic use ; *Autoimmune Diseases ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/*immunology/prevention & control/therapy ; Immunosuppression ; Islets of Langerhans/immunology ; Isoantibodies ; Lymphocytes/*immunology ; Rats
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  • 162
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-06
    Description: Pigeons were trained to perform delayed matching to samples of food and no food when each sample concurrently served as the outcome of a discrimination learning trial which immediately preceded each matching trial. Ambient light presented during the delays after the samples of food or no food severely disrupted matching but had no effect on the rate of discrimination learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maki, W S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):83-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432629" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association ; Columbidae/physiology ; Discrimination Learning/*physiology ; Memory/*physiology ; Memory, Short-Term/*physiology
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  • 163
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-14
    Description: Progress was rapid in attempts to develop lines of quail resistant to acute aflatoxicosis induced by oral dosing with aflatoxin. After five generations of selection, 8- and 11-fold differences were present in mortality between two selected lines and their respective control lines. These quail lines should be of value in investigating the physiological basis of resistance to aflatoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marks, H L -- Wyatt, R D -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515737" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxins/*pharmacology ; Animals ; Coturnix/*genetics ; *Drug Resistance ; Female ; Genes ; Male ; Quail/*genetics ; Selection, Genetic
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  • 164
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: In the normal newborn rat the retinotectal pathway from each eye distributes across the whole area of both the ipsilateral and contralateral superior colliculus. Most of the ipsilateral projection retracts during the first ten postnatal days to produce the normal adult pattern, but retraction fails to occur if one eye is removed at birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Land, P W -- Lund, R D -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):698-700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462177" target="_blank"〉PubMed〈/a〉
    Keywords: Albinism/physiopathology ; Animals ; Animals, Newborn/growth & development ; Functional Laterality ; Optic Chiasm/growth & development ; Rats ; Retina/*growth & development ; Superior Colliculi/cytology/*growth & development ; Visual Pathways/*growth & development
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  • 165
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-22
    Description: The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus. Extensive neuronal loss and gliosis were observed around the injection site. In addition, a significant and consistent 25 percent depletion of hippocampal-cortical noradrenaline was also obtained. The results suggest that although kainic acid has its greatest destructive action on neuronal perikarya, a significant amount of damage to axons of passage may also occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451544" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*drug effects ; Animals ; Brain/metabolism ; Brain Stem/cytology/drug effects ; Cerebral Cortex/drug effects ; Hippocampus/drug effects ; Hydroxydopamines/pharmacology ; Kainic Acid/*pharmacology ; Locus Coeruleus/drug effects ; Male ; Neurons/*drug effects/ultrastructure ; Norepinephrine/metabolism ; Pyrrolidines/*pharmacology ; Rats
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  • 166
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-07
    Description: The subfornical organ, a circumventricular structure of the central nervous system, has efferent neural projections to sites within the brain known to be involved in drinking behavior and secretion of antidiuretic hormone. By using anterograde tracing techniques, it is shown that the subfornical organ projects to the nucleus medians of the medial preoptic area, to the organum vasculosum of the lamina terminalis, and to the supraoptic nuclei bilaterally. Its efferent connectivity is confirmed by retrograde transport of horseradish peroxidase. The organum vasculosum of the lamina terminalis, another circumventricular organ and a suspected receptor site for angiotensin II, is involved in the circuitry of the subfornical organ and also has an efferent projection to the supraoptic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miselis, R R -- Shapiro, R E -- Hand, P J -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cerebral Ventricles/*cytology ; Drinking Behavior/physiology ; Efferent Pathways/physiology ; Male ; Neurosecretory Systems/*physiology ; Preoptic Area/cytology ; Rats ; Subfornical Organ/cytology/*physiology ; Supraoptic Nucleus/cytology ; *Water-Electrolyte Balance
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  • 167
    Publication Date: 1979-07-20
    Description: The trajectory of the intracortical noradrenergic fibers has been characterized by histochemical analysis following the production of cortical lesions in the rate. A large group of noradrenergic fibers enters the cortex at the frontal pole and proceeds caudally through the deep layers of dorsolateral cortex. Branches arise from these longitudinally directed fibers and form a uniform pattern of innervation throughout lateral cortex. Because these fibers travel long distances rostrocaudally within the gray matter, a large area of cortex can be deprived of noradrenergic innervation by a relatively small lesion of frontal cortex. The medial and lateral cortex can be selectively and differentially denervated of noradrenergic fibers, and there is a medial to lateral topographic relationship between deep longitudinally running fibers and overlying cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morrison, J H -- Molliver, M E -- Grzanna, R -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):313-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*physiology ; Gyrus Cinguli/physiology ; Nerve Fibers/*ultrastructure ; Norepinephrine/*physiology ; Pia Mater/physiology ; Rats
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  • 168
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-10
    Description: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagase, S -- Shimamune, K -- Shumiya, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/*blood ; Chromosome Disorders ; Crosses, Genetic ; Female ; Immunoelectrophoresis ; Male ; Mutation ; Rats/*genetics ; Serum Albumin/*deficiency ; Serum Globulins/analysis
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  • 169
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-23
    Description: More than 19,000 multisign utterances of an infant chimpanzee (Nim) were analyzed for syntactic and semantic regularities. Lexical regularities were observed in the case of two-sign combinations: particular signs (for example, more) tended to occur in a particular position. These regularities could not be attributed to memorization or to position habits, suggesting that they were structurally constrained. That conclusion, however, was invalidated by videotape analyses, which showed that most of Nim's utterances were prompted by his teacher's prior utterance, and that Nim interrupted his teachers to a much larger extent than a child interrupts an adult's speech. Signed utterances of other apes (as shown on films) revealed similar non-human patterns of discourse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terrace, H S -- Petitto, L A -- Sanders, R J -- Bever, T G -- New York, N.Y. -- Science. 1979 Nov 23;206(4421):891-902.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504995" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Humans ; Language Development ; Male ; Pan troglodytes/*physiology ; Semantics ; Sign Language ; Time Factors
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  • 170
    Publication Date: 1979-10-19
    Description: The nucleotide sequence of a cloned rabbit chromosomal DNA segment of 1620 nucleotides length which contains a beta-globin gene is presented. The coding regions are separated into three blocks by two intervening sequences of 126 and 573 base pairs, respectively. The rabbit sequence was compared with a homologous mouse sequence. The segments flanking the rabbit gene, as well as the coding regions, the 5' noncoding and part of the 3' noncoding messenger RNA sequences are similar to those of the mouse gene; the homologous introns, despite identical location, are distinctly dissimilar except for the junction regions. Homologous introns may be derived from common ancestral introns by large insertions and deletions rather than be multiple point mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Ooyen, A -- van den Berg, J -- Mantei, N -- Weissmann, C -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):337-44.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Genetic Linkage ; Globins/*genetics ; Mice/*genetics ; Rabbits/*genetics
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  • 171
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
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  • 172
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Upton, A C -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):746.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; *Drug Evaluation, Preclinical ; *National Institutes of Health (U.S.) ; United States
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  • 173
    Publication Date: 1979-03-30
    Description: Curare is known to be less effective as an acetycholine antagonist when the divalent cation concentration of the extracellular solution is increased. This observation can be accounted for by the negative surface potential on the end plate; an increase in divalent cation concentration decreases the negativity of the surface potential and thereby lowers the concentrations of cations at the membrane-solution interface. The concentration of divalent cations, such as curare, will be reduced more than the concentration of univalent cations, such as acetylcholine. The observations can be accounted for by a surface potential of about -50 millivolts. The same principle can explain the reported actions of divalent cations on the affinity of receptors for acetylcholine. The effects of surface potential on concentrations at active sites may play an important role in drug interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van der Kloot, W G -- Cohen, I -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1351-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424757" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*pharmacology ; Animals ; Anura ; Curare/*pharmacology ; Drug Interactions ; Electric Conductivity ; Ions ; *Membrane Potentials ; Models, Biological ; Motor Endplate/*physiology ; Neuromuscular Junction/*physiology ; Receptors, Cholinergic/*drug effects
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  • 174
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-08
    Description: Intracellular recordings show that (i) paramecia hyperpolarize slightly in attractants and depolarize in repellents that depend on the avoiding reaction (an abrupt change of swimming direction), and (ii) paramecia more strongly hyperpolarize in repellents and more strongly depolarize in attractants that depend on changes of swimming velocity. These membrane potential changes are in agreement with a hypothesis of membrane potential control of chemokinesis in Paramecium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Houten, J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1100-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; *Chemotaxis ; Escape Reaction/physiology ; *Membrane Potentials ; Mutation ; Paramecium/*physiology
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  • 175
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
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  • 176
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
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  • 177
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-10
    Description: The subicular cortices of the primate hippocampal formation form a physical and connectional link between the cortex of the temporal lobe and the hippocampus. Their direct connections with all classes of cortex in the temporal lobe except primary sensory cortex underscore the pivotal role of these areas in the potential interplay between the hippocampal formation and the association cortices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Hoesen, G W -- Rosene, D L -- Mesulam, M M -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):608-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109926" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Haplorhini ; Hippocampus/anatomy & histology/*physiology ; Macaca mulatta ; Temporal Lobe/anatomy & histology/*physiology
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  • 178
    Publication Date: 1979-05-25
    Description: Red fluorescent Evans blue and blue fluorescent DAPI-primuline were injected into the anterior-medial and lateral-caudal forebrains, respectively, of the same rats. Separate clusters of cells labeled by retrograde transport were observed in the substantia nigra, while in the dorsal raphe many cells were double-labeled. Thus, single raphe cells send divergent axon collaterals to widespread forebrain areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Kooy, D -- Kuypers, H G -- New York, N.Y. -- Science. 1979 May 25;204(4395):873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441742" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping/methods ; Brain Stem/*cytology ; Cerebral Cortex/*cytology ; Fluorescent Dyes ; Neural Pathways/cytology ; Raphe Nuclei/*cytology ; Rats ; Substantia Nigra/*cytology
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  • 179
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-25
    Description: Specific binding of ovine prolactin was found in microsomal preparations of tail, gill, and kidney of the bullfrog Ran catesbeiana. Binding by larval and adult liver and by kidney before larval stage XVII was low or nondetectable. Renal binding increased during metamorphic climax and in response to treatment with thyroid hormone. The emergence of renal binding of prolactin may signify a shift in the hormone's participation in the control of hydromineral homeostasis from the gill, which is resorbed, to the kidney. A renal action of prolactin during climax may facilitate metamorphosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, B A -- Nicoll, C S -- New York, N.Y. -- Science. 1979 May 25;204(4395):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/220708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gills/metabolism ; Kidney/metabolism ; Kinetics ; Liver/metabolism ; *Metamorphosis, Biological ; Microsomes/metabolism ; Prolactin/*physiology ; Rana catesbeiana/*growth & development ; Receptors, Cell Surface/*metabolism ; Tail/metabolism ; Thyroxine/pharmacology ; Water-Electrolyte Balance
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  • 180
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-19
    Description: Identified reticulospinal neurons whose giant axons were severed after spinal cord transection were filled with horseradish peroxidase. Whole mounts and serial-section light and electron micrographs show axon regeneration across the spinal lesion and the formation of new synapses. Normal swimming activity returns in the spinally transected animals, although the regenerated synapses are in atypical regions of the spinal cord.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wood, M R -- Cohen, M J -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):344-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482943" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Fishes/*physiology ; Lampreys/*physiology ; Movement ; *Nerve Regeneration ; Spinal Cord/*physiology ; Synapses/physiology
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  • 181
    Publication Date: 1979-07-27
    Description: The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing gamma-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zieglgansberger, W -- French, E D -- Siggins, G R -- Bloom, F E -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Endorphins/*pharmacology ; Enkephalins/*pharmacology ; Hippocampus/drug effects/*physiology ; Magnesium/pharmacology ; Neurons/drug effects/*physiology ; Rats
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  • 182
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-06
    Description: The methods of Fechner and Stevens for assessing sensation quantity usually yield different psychophysical functions even when all other factors are controlled. In this experiment, corresponding differences occurred when different features of the same sensory receptor signals were analyzed. In the visual system, the receptor potential saturated if the peak but not the area was measured; these results match visual psychophysical functions obtained with the methods of Fechner and Stevens, respectively. This result suggests that both methods are equally valid but that each method yields the particular psychophysical function appropriate for a particular kind of information processing. A novel factor in determining sensation quantity, namely the time used by the observer to make a judgment, is implicated by the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wasserman, G S -- Felsten, G -- Easland, G S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Radiation ; Evoked Potentials ; Horseshoe Crabs ; Humans ; Light ; Models, Neurological ; Photoreceptor Cells/*physiology ; Visual Perception/*physiology
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  • 183
    Publication Date: 1979-02-09
    Description: The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyatt, R G -- Mebus, C A -- Yolken, R H -- Kalica, A R -- James, H D Jr -- Kapikian, A Z -- Chanock, R M -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):548-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/216077" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/immunology ; Cattle ; Cross Reactions ; Diarrhea, Infantile/prevention & control ; Germ-Free Life ; Humans ; Immunization ; RNA Viruses/*immunology ; Rotavirus/*immunology ; Species Specificity ; Viral Vaccines/immunology ; Virus Diseases/*prevention & control
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  • 184
    Publication Date: 1979-11-02
    Description: Horseradish peroxidase (HRP) in the presence of specific immunoglobulin G antibody to HRP is selectively absorbed from the gut lumen and transferred by intestinal epithelial cells to the lamina propria in newborn rats. The HRP is not transferred in detectable amounts in the absence of the antibody. Transport of maternally derived antigen via antigen-antibody complexes may have important influences on the developing immune system in young mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamson, D R -- Powers, A -- Rodewald, R -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):567-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; *Antigen-Antibody Complex ; *Antigens ; Biological Transport, Active ; Female ; Horseradish Peroxidase/immunology ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; *Intestinal Absorption ; Jejunum/*immunology/metabolism ; Male ; Rats
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  • 185
    Publication Date: 1979-06-29
    Description: Chick ciliary ganglionic neurons require an interaction with their peripheral targets for survival during a critical period of their embryonic development in vivo. It has recently been shown that survival of these neurons in dissociated cell cultures is supported by extract from whole chick embryo. In this study, an assay system based on microwell cultures of ciliary ganglionic neurons was used to demonstrate that a very rich source of trophic factor for them is the intraocular target tissues they innervate. Out of 8000 trophic units present in a 12-day embryo, 2500 were contained in the eye. A subdissection of the eye showed its activity to be localized in a fraction containing the ciliary body and choroid coat, with a specific activity almost 20-fold higher than that of the whole embryo. This selective intraocular distribution at a time when survival or death of ciliary ganglionic neurons is decided in vivo suggests that this soluble factor may be involved in the normal development of the ciliary ganglion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, R -- Landa, K B -- Manthorpe, M -- Varon, S -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451576" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Survival ; Chick Embryo ; Cholinergic Fibers/*embryology ; Ciliary Body/embryology/*innervation ; Embryonic Induction ; Ganglia/*embryology ; Nerve Growth Factors/*metabolism ; Tissue Distribution
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  • 186
    Publication Date: 1979-04-20
    Description: A retrovirus previously isolated from a tumored Russell's viper is shown by molecular hybridization to be an endogenous virus of this reptilian species. Radio-immunologic techniques revealed that the viper retrovirus is immunologically and, hence, evolutionarily related to endogenous type D retorviruses of Old World primates. These findings extend the number of vertebrate classes possessing endogenous retroviruses and suggest that type D retroviruses may even be more widely distributed in nature than type C retroviruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andersen, P R -- Barbacid, M -- Tronick, S R -- Clark, H F -- Aaronson, S A -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):318-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219480" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Base Sequence ; *Biological Evolution ; *Genes, Viral ; Nucleic Acid Hybridization ; Primates/*microbiology ; Retroviridae/*genetics/immunology ; Snakes/genetics/*microbiology ; Viral Proteins/immunology
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  • 187
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
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  • 188
    Publication Date: 1979-12-14
    Description: Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baetens, D -- Malaisse-Lagae, F -- Perrelet, A -- Orci, L -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/390711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catheterization ; Glucagon/metabolism ; Insulin/metabolism ; Islets of Langerhans/*anatomy & histology/metabolism ; Pancreatic Polypeptide/metabolism ; Rats ; Somatostatin/metabolism
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  • 189
    Publication Date: 1979-05-11
    Description: The vascular smooth muscle of cerebral blood vessels is relatively insensitive to sympathomimetic stimulation compared with muscle from systemic vessels. The transition in the vertebral artery occurs just rostral to the emergence of that artery from the foramen of the lateral process of the atlas and in the internal carotid artery just before it enters the carotid canal. These sites in the adult correspond to embryological junctions between segments of the vertebral and internal carotid arteries derived from the primitive dorsal aortas and their branches with vessels originating locally from the bilateral longitudinal neural arteries. Topographic patterns of vascular properties may in some cases be explained by the different sites of origin of their primordial mesodermal cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevan, J A -- New York, N.Y. -- Science. 1979 May 11;204(4393):635-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432670" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/embryology ; Animals ; Carotid Artery, Internal/embryology/*innervation ; Cerebral Arteries/embryology/innervation ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects/innervation ; Norepinephrine/*pharmacology ; Rabbits ; Vertebral Artery/embryology/*innervation
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  • 190
    Publication Date: 1979-11-16
    Description: Embryonic chick lens epithelial cells cultured in serum-supplemented medium elongated in the absence of microtubules after treatment with the antimicrotubule drug nocodazole. Colchicine, at concentrations lower than those that dissociate microtubules, blocks cell elongation and the associated increase in cell volume. These results indicate that an increase in cell volume, not microtubules, is responsible for lens cell elongation and suggest a previously undescribed effect of colchicine on cell volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beebe, D C -- Feagans, D E -- Blanchette-Mackie, E J -- Nau, M E -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):836-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Cells, Cultured ; Chick Embryo ; Colchicine/*pharmacology ; Epithelium/ultrastructure ; Lens, Crystalline/*cytology ; Microtubules/*drug effects
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  • 191
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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  • 192
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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  • 193
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-07
    Description: The sex of hatchling map turtles is determined by incubation temperature of eggs in the laboratory as well as in nature. Temperature controls sex differentiation rather than causing a differential mortality of sexes. Temperature has no effect on sex determination in a soft-shelled turtle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Vogt, R C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genotype ; Male ; *Sex Determination Analysis ; Species Specificity ; Temperature ; Turtles/*physiology
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  • 194
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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  • 195
    Publication Date: 1979-08-24
    Description: Previous studies on the genome of Strongylocentrotus purpuratus sea urchin have shown that changes in the nucleotide sequence of inverted repeat sequences occur during embryogenesis. The present study indicates that these sequence changes fail to occur when the embryos are raised in the presence of 5-bromodeoxyuridine. This drug is an analog of thymidine, is incorporated into the DNA during embryogenesis, and inhibits cell differentiation in these embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickinson, D G -- Baker, R F -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):816-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence/*drug effects ; Bromodeoxyuridine/*pharmacology ; DNA Replication/*drug effects ; Female ; Ovum/*metabolism ; Sea Urchins
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  • 196
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-10-12
    Description: The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dukelow, W R -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone/pharmacology ; Haplorhini/*physiology ; Ovulation/*drug effects ; Saimiri/*physiology
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  • 197
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-04-06
    Description: An excitatory synaptic potential in a local nonspiking interneuron of a locust is able to effect the release of chemical transmitter. The consequence is that a discrete inhibitory synaptic potential is evoked in an identified postsynaptic motoneuron. These local interactions between interneurons and motoneurons are of behavioral significance in that they ensure the correct operation of a resistance reflex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burrows, M -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/34878" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Extremities/innervation ; Grasshoppers ; Interneurons/*physiology ; Membrane Potentials ; Motor Neurons/physiology ; Neural Inhibition ; Neurotransmitter Agents/*metabolism ; Synaptic Membranes/*physiology
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  • 198
    Publication Date: 1979-09-28
    Description: Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamide, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone-dependent mammary tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho-Chung, Y S -- Archibald, D -- Clair, T -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224463" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene ; Animals ; Cell Nucleus/metabolism ; Cell-Free System ; Chromosomal Proteins, Non-Histone/*metabolism ; Cyclic AMP/*metabolism ; Female ; Mammary Neoplasms, Experimental/*metabolism ; Neoplasm Proteins/metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Cyclic AMP/*metabolism
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  • 199
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-07-20
    Description: Rats given continuous access to etonitazene hydrochloride in their drinking water (5 micrograms per milliliter) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self-administered etonitazene (10 micrograms per kilogram) intravenously on a continuous reinforcement schedule, and the number of infusions increased significantly on days when they were deprived of food. These results suggest that feeding condition may be a powerful determinant of drug-reinforced behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, M E -- France, C P -- Meisch, R A -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36665" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*administration & dosage ; Drinking Behavior ; *Food Deprivation ; Humans ; Injections, Intravenous ; Male ; Rats ; Self Administration ; Stereotyped Behavior/physiology
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  • 200
    Publication Date: 1979-10-19
    Description: Experimental infection of hamster ciliated tracheal epithelium in organ culture with virulent Mycoplasma pneumoniae resulted in the deterioration o ciliary necklaces and an altered distribution of membrane-associated particles on the shafts of the affected cilia. To our knowledge that is the first report of an altered disposition of ciliary membrane-associated particles in response to a specific infectious agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carson, J L -- Collier, A M -- Clyde, W A Jr -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113877" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/ultrastructure ; Cilia/ultrastructure ; Cricetinae ; Culture Techniques ; Epithelium/ultrastructure ; Mycoplasma Infections/*pathology ; Mycoplasma pneumoniae ; Trachea/*pathology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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