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  • Cells, Cultured  (28)
  • American Association for the Advancement of Science (AAAS)  (28)
  • American Meteorological Society
  • 1980-1984
  • 1975-1979  (28)
  • 1970-1974
  • 1925-1929
  • 1978  (28)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (28)
  • American Meteorological Society
Years
  • 1980-1984
  • 1975-1979  (28)
  • 1970-1974
  • 1925-1929
Year
  • 1
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Murine lymphoma-induced immunosuppression: requirement for direct tumour cell contact (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: The FBL-3 lymphoma cell line caused impaired antibody formation in vivo when injected into mice intraperitoneally, and in vitro when added to normal syngeneic spleen cells immunized in vitro with sheep erythrocytes. Immunosuppression occurred only when intact viable tumor cells were cocultivated with the normal spleen cells. As few as 10(5) FBL-3 cells, when added to 5 X 10(6) normal cells, impaired antibody formation. However, cell-free extracts of filtrates from even much larger numbers of tumor cells did not affect antibody formation, either in vitro or in vivo. Heating the tumor cells at 56 degrees C or irradiation with as little as 1000 rads completely abolished immunosuppressive activity, both in vitro and in vivo. Separation of viable tumor cells from target antibody-forming cells by cell-impermeable membranes prevented immunosuppression, showing that direct cell-to-cell contact is required for immunosuppression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cimprich, R S -- Specter, S -- Friedman, H -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):60-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635572" target="_blank"〉PubMed〈/a〉
    Keywords: *Antibody Formation ; Cell Communication ; Cells, Cultured ; *Immunosuppression ; Lymphoma/*immunology ; Neoplasms, Experimental/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Diazepam inhibits myoblast fusion and expression of muscle specific protein synthesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The presence of diazepam in culutres of chicken embryo myoblasts arrests normal muscle cell differentiation. High concentrations of the drug reversibly prevent myoblasts from fusing to form multinucleated myotubes. Lower concentrations of diazepam allow cell fusion to occur, but inhibit the synthesis and accumulation of myosin heavy chain, implying that cell fusion does not obligate myoblasts to synthesize and accumulate large quantities of muscle specific protein. The effect of diazepam on muscle cells in culture is direct and specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bandman, E -- Walker, C R -- Strohman, R C -- New York, N.Y. -- Science. 1978 May 5;200(4341):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Fusion/drug effects ; Cells, Cultured ; Chick Embryo ; Diazepam/*pharmacology ; Dose-Response Relationship, Drug ; Macromolecular Substances ; Muscles/cytology/*drug effects ; Myosins/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Neale, J H -- Smith, T G Jr -- Macdonald, R L -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204016" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Excitatory Amino Acid Antagonists ; Glutamates/*pharmacology ; Iontophoresis ; Naloxone/pharmacology ; Neurons/*drug effects ; Spinal Cord ; Synapses/*drug effects ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Loss of division potential in vitro: aging or differentiation? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: We have examined the hypothesis that diploid cells grown in vitro age, and propose that only proliferative potential and not life-span is telescoped. We suggest that explanted or transplanted diploid cells are driven to divide by the process of subculturing in vitro or in vivo and, in response to this pressure, also complete their differentiation and become refractory to further mitotic stimulation. We conclude that differentiation rather than "mortality" distinguishes diploid from transformed cells and that the former may not age in vitro, but are lost because culture methods are selective for cycling cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, E -- Marek, L F -- Levinstone, D S -- Merrill, C -- Sher, S -- Young, I T -- Eden, M -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1158-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725592" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle ; *Cell Differentiation ; *Cell Division ; *Cell Survival ; Cells, Cultured ; Fibroblasts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Neurotrophic protein regulates muscle acetylcholinesterase in culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oh, T H -- Markelonis, G J -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635593" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholinesterase/biosynthesis/*metabolism ; Cells, Cultured ; Enzyme Induction/drug effects ; Muscle Denervation ; Muscles/*enzymology ; Nerve Tissue Proteins/*pharmacology ; Peripheral Nerves/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: The opiate etorphine depresses monosynaptic excitatory postsynaptic potentials (EPSP's) elicited in spinal cord cells by activation of dorsal root ganglion cells in murine neuronal cell culture. The depression is reversed by naloxone. Statistical analysis of the synaptic responses reveals that the opiate reduces EPSP quantal content at this synapse without altering quantal size. Therefore, the opiate action is presynaptic and affects transmitter release rather than postsynaptic responsiveness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Nelson, P G -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204015" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Depression, Chemical ; Dose-Response Relationship, Drug ; Etorphine/*pharmacology ; Ganglia, Spinal/*drug effects ; Membrane Potentials/drug effects ; Morphinans/*pharmacology ; Naloxone/pharmacology ; Nerve Endings/drug effects ; Spinal Cord/drug effects ; Synapses/drug effects ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
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  • 9
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    Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raymond, V -- Beaulieu, M -- Labrie, F -- Boissier, J -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/418505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Dihydroergotoxine/antagonists & inhibitors ; *Dopamine Antagonists ; Estradiol/*pharmacology ; Female ; Phenethylamines/antagonists & inhibitors ; Pituitary Gland, Anterior/*drug effects/secretion ; Prolactin/*secretion ; Rats ; Thyrotropin-Releasing Hormone/pharmacology
    Print ISSN: 0036-8075
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  • 10
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    Nature and nurture in development of the autonomic neuron (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Arguments are presented for the hypothesis that during an early stage of development the cells which become principal neurons of the autonomic nervous system possess information regarding the positions they will occupy within the body. A second stage of development, during which a decision is made regarding which neurotransmitter to employ, is delayed until each neuron has assumed its permanent position in the body and has sampled, presumably via its growing axons, the peripheral field which it will innervate. The development of cholinergic mechanisms takes precedence; adrenergic neurons may develop only when cholinergic sites have been occupied. An extended period during which the differentiation of transmitter mechanisms may be modulated permits the neuron to adequately sample the periphery prior to commitment to a specific transmitter economy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunge, R -- Johnson, M -- Ross, C D -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1409-16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24273" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/cytology ; Animals ; Autonomic Nervous System/*embryology/growth & development ; Cell Differentiation ; Cells, Cultured ; Chimera ; Cholinergic Fibers/cytology ; Embryonic Induction ; Ganglia, Autonomic/cytology ; Heart/innervation ; Intestines/innervation ; Nerve Endings/ultrastructure ; Neurotransmitter Agents/metabolism ; Phylogeny ; Synaptic Vesicles/ultrastructure
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Deficiencies of glucosamine-6-sulfate or galactosamine-6-sulfate sulfatases are responsible for different mucopolysaccharidoses (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: [1-3H]Galactitol-6-sulfate, N- [1-3H]acetylgalactosaminitol-6-sulfate, N-[1-3H]acetylglucosaminitol-6-sulfate, N-acetylglucosamine-6-sulfate, and 6-sulfated tetrasaccharides from chondroitin-6-sulfate have been used for the measurement of 6-sulfatase activity of extracts of normal skin fibroblasts and of fibroblasts cultured from patients with genetic mucopolysaccharidoses. With these substrates, extracts of fibroblasts derived from Morquio patients lack or have greatly reduced activities for galactitol-6-sulfate, N-acetylgalactosaminitol-6-sulfate, and 6-sulfated tetrasaccharides but have normal activity for N-acetylglucosamine-6-sulfate and its alditol; those derived from a patient with a newly discovered mucopolysaccharidosis have greatly reduced activity for N-acetylglucosamine-6-sulfate and its alditol but normal activity for galactitol-6-sulfate, N-acetylgalactosaminitol-6-sulfate, and the 6-sulfated tetrasaccharides. These findings demonstrate the existence of two different hexosamine-6-sulfate sulfatases, specific for the glucose or galactose configuration of their substrates. Their respective deficiencies, causing inability to degrade keratan sulfate and heparan sulfate in one case and keratan sulfate and chondroitin-6-sulfate in the other, are responsible for different clinical phenotypes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Di Ferrante, N -- Ginsberg, L C -- Donnelly, P V -- Di Ferrante, D T -- Caskey, C T -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):79-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratories of Connective Tissue Research, Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569489" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylgalactosamine/analogs & derivatives/metabolism ; Acetylglucosamine/analogs & derivatives/metabolism ; Cells, Cultured ; Child, Preschool ; Chondroitin Sulfates/metabolism ; Chondroitinsulfatases/*deficiency/metabolism ; Fibroblasts/enzymology ; Galactitol/metabolism ; Heparitin Sulfate/metabolism ; Humans ; Hydrogen-Ion Concentration ; Keratan Sulfate/metabolism ; Male ; Mucopolysaccharidoses/*enzymology ; Mucopolysaccharidosis III/enzymology ; Mucopolysaccharidosis IV/*enzymology ; Skin/cytology/enzymology ; Substrate Specificity ; Sulfatases/*deficiency/metabolism
    Print ISSN: 0036-8075
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  • 12
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    Age affect and replicative life-span of fibroblasts of diabetic, prediabetic, and normal donors: another look at the data (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gleason, R E -- Goldstein, S -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1217-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725599" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/*physiopathology ; Humans ; Middle Aged ; Prediabetic State/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Entry of insulin into human cultured lymphocytes: electron microscope autoradiographic analysis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: Electron microscope autoradiographs were prepared of IM-9 human cultured lymphocytes incubated with iodine-125-labeled insulin. With the use of [125I]insulin and Ilford L-4 emulsion, the technique had a resolution half-distance of approximately 0.085 micrometer. Autoradiographs revealed a time-dependent entry of insulin into the cell interior that was maximal after 30 minutes of incubation. At this time point nearly 40 percent of the [125I]insulin was in the interior of the cell at a distance 1 micrometer or greater from the plasma membrane. Grain distribution and volume density analyses revealed that the intracellular insulin was concentrated in the endoplasmic reticulum and nuclear membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldfine, I D -- Jones, A L -- Hradek, G T -- Wong, K Y -- Mooney, J S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):760-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715440" target="_blank"〉PubMed〈/a〉
    Keywords: Autoradiography ; Biological Transport ; Cell Nucleus/metabolism ; Cells, Cultured ; Endoplasmic Reticulum/metabolism ; Humans ; Insulin/*metabolism ; Kinetics ; Lymphocytes/*metabolism
    Print ISSN: 0036-8075
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  • 14
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    Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, S -- Moerman, E J -- Soeldner, J S -- Gleason, R E -- Barnett, D M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):781-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622567" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/pathology/*physiopathology ; Fibroblasts/*cytology/pathology ; Humans ; Middle Aged ; Prediabetic State/pathology/*physiopathology ; Regression Analysis ; Skin/cytology/pathology
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  • 15
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    Pattern formation by cultured human epidermal cells: development of curved ridges resembling dermatoglyphs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: In cultures made from disaggregated human epidermal cells, growth to a confluent cell layer is followed by the emergence of patterns resembling those of human dermatoglyphs. These patterns reflect intrinsic properties of kertinocytes. In vivo, only the epidermis of the volar surfaces forms patterns, but in culture, patterns are formed by epidermal cells from other sites as well. Patterns develop by a process of cell movement which first produces ridges and then curves the ridges into figures of increasing complexity, ultimately whorls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, H -- Thomas, J -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663617" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Movement ; Cells, Cultured ; *Dermatoglyphics ; Embryonic Induction ; Epidermis/*cytology ; Fibroblasts/cytology ; Humans ; Time Factors
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  • 16
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    Lichen myxedematosus serum stimulates human skin fibroblast proliferation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: Serum from patients with lichen myxedematosus, when added to exponentially growing normal human skin fibroblasts, stimulates DNA synthesis and cell proliferation. The degree of response in vitro is correlated with the extent of the disease in vivo and is specific for fibroblasts. The results suggest that there is a systemic factor (or factors) which may play a role in the etiology of diseases affecting the connective tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Rispler, J -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):545-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622555" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Humans ; Immunoglobulin G/analysis ; Male ; Middle Aged ; Skin Diseases/*blood/immunology/pathology ; Thymidine/metabolism
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  • 17
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    Chemotactic antibody (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Antibody of the immunoglobulin G class to herpes simplex virus and antibody of the immunoglobulin M class to sheep red blood cells were coupled to the synthetic peptide formylmethionylleucylphenylalanine (fMet-Leu-Phe), which is chemotactic for both mononuclear and polymorphonuclear leukocytes. The resulting molecules were chemotactic and retained their antigen-binding activity. When antibodies coupled to fMet-Leu-Phe were incubated with antigen, the resulting immune complexes were also chemotactic. Chemotactic antibody may provide a potent means of enhancing the migration of inflammatory cells to specific sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isturiz, M A -- Sandberg, A L -- Schiffmann, E -- Wahl, S M -- Notkins, A L -- New York, N.Y. -- Science. 1978 May 5;200(4341):554-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205950" target="_blank"〉PubMed〈/a〉
    Keywords: *Antibodies ; Antibodies, Viral ; Antigen-Antibody Complex ; Cells, Cultured ; Chemotaxis, Leukocyte/*drug effects ; Erythrocytes/immunology ; Immunoglobulin G ; Immunoglobulin M ; Inflammation/immunology ; Oligopeptides/*pharmacology ; Simplexvirus/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Enkephalin-containing neurons visualized in spinal cord cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Neuronal cells, axons, and terminals containing immunoreactive enkephalin have been visualized in cultures of dissociated fetal spinal cord. These cultures may provide a valuable system in which to explore the effects of chronic drug treatment on the physiology of enkephalin-containing cells and their interactions with other cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neale, J H -- Barker, J L -- Uhl, G R -- Snyder, S H -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):467-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351811" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Fluorescent Antibody Technique ; Ganglia, Spinal/metabolism ; Mice ; Neurons/*metabolism ; Spinal Cord/cytology/embryology/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Reovirus type 3, passaged in pancreatic beta-cell cultures, produced an insulitis when inoculated into 1- to 2-week-old mice. By means of a double-label antibody technique, in which we used fluorescein-labeled antibody to reovirus and rhodamine-labeled antibody to insulin, reovirus antigens were found in beta cells. By electron microscopy, viral particles in different stages of morphogenesis were observed in insulin-containing beta cells but not glucagon-containing alpha cells. The infection resulted in destruction of beta cells, reduction in the insulin content of the pancreas, and alteration in the host's capacity to respond normally to a glucose tolerance test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onodera, T -- Jenson, A B -- Yoon, J W -- Notkins, A L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Cells, Cultured ; Diabetes Mellitus, Experimental/etiology/metabolism/*microbiology ; Diabetes Mellitus, Type 1/microbiology ; Insulin/metabolism ; Islets of Langerhans/metabolism/*microbiology ; Mammalian orthoreovirus 3/immunology ; Mice ; Reoviridae Infections/*complications ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Antibody-dependent lymphocytotoxicity induced by immunoglobulin G from Hodgkin's disease splenic lymphocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Immunoglobulin G, produced in cultures of splenic lymphocytes obtained from patients with Hodgkin's disease, bound to a population of homologous peripheral blood lymphocytes and initiated antibody-dependent cell cytotoxicity in cultures from five out of eight patients. Two patients whose cultures produced negative results had minimal disease; the other was in remission. The target cells appear to be T lymphocytes; the effector cells bear Fc receptors that are inhibited by antigen-antibody complexes. Antibody-dependent cell cytotoxicity events may produce the anergy and lymphopenia often seen in Hodgkin's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Longmire, R L -- Ryan, S -- McMillan, R -- Lightsey, A -- Heath, V -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):71-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Hematology and Oncology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569485" target="_blank"〉PubMed〈/a〉
    Keywords: *Antibody-Dependent Cell Cytotoxicity ; Cells, Cultured ; Hodgkin Disease/*immunology ; Humans ; Immunoglobulin G/*immunology ; Lymphocytes/*immunology ; Spleen/cytology/immunology ; T-Lymphocytes/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Papayannopoulou, T -- Nakamoto, B -- Buckley, J -- Kurachi, S -- Nute, P E -- Stamatoyannopoulos, G -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1349-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628844" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anemia, Sickle Cell/blood ; Cell Differentiation ; Cells, Cultured ; Fetal Hemoglobin/*biosynthesis ; Hematopoietic Stem Cells/cytology/*metabolism ; Hemoglobin A/biosynthesis ; Hemoglobin, Sickle/biosynthesis ; Humans ; Reticulocytes/metabolism ; Thalassemia/blood
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Ultraviolet radiation--induced chromosomal abnormalities in fetal fibroblasts from New Zealand black mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, A L -- Fialkow, P G -- Salo, A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; *Chromosome Aberrations ; Chromosomes/*radiation effects ; Disease Models, Animal ; Dose-Response Relationship, Radiation ; Mice ; Mice, Inbred BALB C/physiology ; Mice, Inbred NZB/*physiology ; *Ultraviolet Rays ; Xeroderma Pigmentosum/physiopathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Gene amplification and drug resistance in cultured murine cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: Resistance of mouse cells to the folate analog, methotrexate, results from selection of increasingly resistant cells on progressive increases of methotrexate in the culture medium. High-level resistance is associated with high rates of synthesis of dihydrofolate reductase and correspondingly high numbers of reductase genes. In some variants high resistance and gene copy number are stable in the absence of selection pressure, whereas in others they are unstable. Analogies are made to antibiotic and insecticide resistance wherein selection of organisms with increased capacity to counteract the drug effect results in emergence of resistance. Gene amplification may underlie many such resistance phenomena.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schimke, R T -- Kaufman, R J -- Alt, F W -- Kellems, R F -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1051-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715457" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Cells, Cultured ; Crossing Over, Genetic ; DNA Replication ; *Drug Resistance ; Folic Acid Antagonists ; *Genes ; Methotrexate/*pharmacology ; RNA, Messenger/genetics ; Tetrahydrofolate Dehydrogenase/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Growth of infective forms of Trypanosoma rhodesiense in vitro, the causative agent of African trypanosomiasis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: A new approach to the culture of African trypanosomes led to the growth of the infective forms of the causative agent of human African trypanosomiasis. Infective cultures of Trypanosoma rhodesiense were initiated and maintained in vitro on Chinese hamster lung cells. By changing daily one-third of the Hepes-buffered RPMI 1640 medium containing 20 percent fetal bovine serum, the trypanosome numbers increased to 3 X 10(6) to 5 X 10(6) cells per milliliter. After 80 days in vitro at 37 degrees C, the cultured trypomastigotes are infective for mice and rats and morphologically similar to bloodstream trypomastigotes in having a subterminal kinetoplast and a surface coat. In addition, they possess L-alpha-glycerophosphate oxidase, the predominant steady-state terminal oxidase of bloodstream trypomastigotes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, G C -- Shimer, S P -- Caughey, B -- Sauer, L S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):763-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Oxidoreductases/metabolism ; Trypanosoma brucei brucei/cytology/enzymology/*growth & development ; Trypanosomiasis, African/*parasitology
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  • 26
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    Preparation of sarcolemmal membrane from myocardial tissue culture monolayer by high-velocity gas dissection (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: A high-velocity stream of nitrogen is used to simultaneously disrupt myocardial cells in monolayer culture and fractionate their sarcolemmal membranes. The membranes show a high degree of ultrastructural and enzymatic purity, with less than 1 percent intracellular residuum. They are produced in less than 1 second and remain as tightly adherent sheets on the surface on which the cells were grown. The cells are exposed to no agent other than nitrogen gas during the preparative procedure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langer, G A -- Frank, J S -- Philipson, K D -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1388-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Fractionation/methods ; Cells, Cultured ; Ferritins ; Membrane Proteins/analysis ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Myocardium/ultrastructure ; Nitrogen ; Rats ; *Sarcolemma/analysis/ultrastructure
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  • 27
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    Switch in immunoglobulin class production observed in single clones of committed lymphocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Mouse spleen cells, after stimulation with lipopolysaccharide, were cloned in culture. After 4 to 5 days, the daughter cells were stained and examined for immunoglobulin class with double immunofluorescent reagents. A switch of the stained color of these cells was observed, implying a switch from imunoglobulin M to immunoglobulin G production in the progeny of a single B cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wabl, M R -- Forni, L -- Loor, F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1078-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/305113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Cells, Cultured ; Clone Cells/immunology ; Cytoplasm/immunology ; Immunoglobulin Fc Fragments ; Immunoglobulin G/*biosynthesis ; Immunoglobulin M/*biosynthesis ; Mice ; Receptors, Antigen, B-Cell/biosynthesis ; Spleen/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 28
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    Collagenase immunolocalization in cultures of rheumatoid synovial cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Cultures of rheumatoid synovial cells that have been enzymatically dissociated and are adherent to a culture vessel are morphologically heterogeneous. When these cells are cultured on a collagenous substrate for 2 to 6 days at 37 degrees C in serum-free medium, they produce collagenase. A monospecific antibody to human collagenase has localized the enzyme extracellularly around cytoplasmic extensions of dendritic cells and intracellularly within a few macrophage-like and fibroblast-like cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woolley, D E -- Harris, E D Jr -- Mainardi, C L -- Brinckerhoff, C E -- New York, N.Y. -- Science. 1978 May 19;200(4343):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205952" target="_blank"〉PubMed〈/a〉
    Keywords: Arthritis, Rheumatoid/*enzymology ; Cells, Cultured ; Fibroblasts/enzymology ; Humans ; Microbial Collagenase/antagonists & inhibitors/*metabolism ; Synovial Fluid/cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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