Publication Date:
1998-08-26
Description:
In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Munn, D H -- Zhou, M -- Attwood, J T -- Bondarev, I -- Conway, S J -- Marshall, B -- Brown, C -- Mellor, A L -- New York, N.Y. -- Science. 1998 Aug 21;281(5380):1191-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9712583" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Enzyme Inhibitors/pharmacology
;
Female
;
Fetus/*immunology
;
Genes, MHC Class I
;
Genes, RAG-1
;
H-2 Antigens/genetics
;
Humans
;
*Immune Tolerance
;
Indoleamine-Pyrrole 2,3,-Dioxygenase
;
Macrophage Colony-Stimulating Factor/physiology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred CBA
;
Placenta/enzymology
;
Pregnancy
;
T-Lymphocytes/*immunology/metabolism
;
Transgenes
;
Trophoblasts/*enzymology
;
Tryptophan/analogs & derivatives/*metabolism/pharmacology
;
Tryptophan Oxygenase/antagonists & inhibitors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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