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  • Books  (5,687)
  • Frontiers Media SA  (2,449)
  • De Gruyter  (2,066)
  • Routledge  (1,171)
  • Madrid : Secc
  • 2020-2024  (5,687)
  • 2020-2020
  • 1965-1969  (1)
  • 2021  (5,687)
  • 1981
  • 1967  (1)
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Years
Year
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  • 1
    Monograph available for loan
    Monograph available for loan
    Madrid : Secc
    Call number: PIK N 456-17-90913
    Type of Medium: Monograph available for loan
    Pages: 536 Seiten
    Series Statement: Ministerio de Transportes Turismo Y Comunicaciones : Publicación Serie A 114
    Parallel Title: 1,1=6; 2,1=13 von Publicaciones / D / Ministerio del Aire, Subsecretaria de Aviación Civil, Servicio Meteorológico Nacional
    Language: Spanish
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
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    De Gruyter
    Publication Date: 2024-04-14
    Description: This book is an introduction to the subjects of linked data, open data and open linked data, and to their specific relevance for libraries. It illustrates these concepts through detailed descriptions of actual data projects. The volume will be useful to individuals involved in library practice and those in library management who have not yet become familiarized with these important contemporary fields.
    Keywords: Z ; Q350-390 ; Libraries ; Internet ; hyperlinks ; thema EDItEUR::U Computing and Information Technology
    Language: German
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  • 3
    Publication Date: 2022-01-31
    Description: As records of the link between a manuscript and the texts it contains, paratexts document many aspects of a manuscript’s life: production, transmission, usage, and reception. Comprehensive studies of paratexts are still rare in the field of manuscript studies, and the universal categories of time and space are used to create a common frame for research and comparisons. Contributions in this volume span over three continents and one millennium.
    Keywords: PN1-6790 ; Genette ; Gérard ; Paratext
    Language: English
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  • 4
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 5
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    De Gruyter
    Publication Date: 2024-04-08
    Description: The present volume is the seventeenth and last in this series of the Jerusalem Talmud. The four tractates of theSecond Order - Ta'aniot, Megillah, Hagigah, Mo'ed Qatan (Mašqin) - deal with different fasts and holidays as well as with the pilgrimage to the Temple. The texts are accompanied by an English translation and presented with full use of existing Genizah texts and with an extensive commentary explaining the Rabbinic background.
    Keywords: Talmud ; Jewish Studies ; Rabbinic Scripture ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: English , Hebrew
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  • 6
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    Taylor & Francis | The Transformation of Yunnan in Ming China | Routledge
    Publication Date: 2023-09-12
    Description: This book examines how the Ming state transformed the multi-ethnic society of Yunnan into a province. Yunnan had remained outside the ambit of central government when ruled by the Dali kingdom, 937-1253, and its foundation as a province by the Yuan regime in 1276 did not disrupt Dali kingdom style political, social and religious institutions. It was the Ming state in the fourteenth to seventeenth centuries through its institutions for military and civilian control which brought about profound changes and truly transformed local society into a province. In contrast to other studies which have portrayed Yunnan as a non-Han frontier region waiting to be colonised, this book, by focusing on changes in local society, casts off the idea of Yunnan as a border area far from civilisation.
    Keywords: Yunnan, Ming China ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics
    Language: English
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  • 7
    Publication Date: 2024-04-01
    Description: Modern popular culture came to the world from the stage. Even before film and radio had established themselves, popular theater had developed into a commercial and boundary-crossing entertainment industry that reached a mass audience. Tobias Becker compares the theater landscapes of London and Berlin and points out the cultural exchanges that took place between these metropolises during the long turn of the century (1880&#82111930).
    Keywords: D204-475 ; media history ; German-British history ; theater history ; urban history ; history of popular culture ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 8
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 9
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 10
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    De Gruyter
    Publication Date: 2024-04-01
    Description: Psychiatric disorders in adolescents are an important social problem relevant to almost all healthcare professionals. The prevalence of mood, anxiety, substance use and other psychiatric disorders among adolescents is high. However, medical professionals are not sufficiently trained about adolescent psychiatric disorders. Primary care providers correctly identify less than a fourth of youth with a depressive or anxiety disorder and many clinicians underestimate the importance of the problem of adolescent psychiatric illnesses and suicidal behavior. Multiple clinical, neurobiological, cultural and legal aspects of psychiatric disorders in adolescents are discussed in this book.
    Keywords: Medicine & Public Health ; Medicine ; Public Health ; Psychiatric disorders ; Adolescence ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKL Psychiatry
    Language: English
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  • 11
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 12
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 13
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    Taylor & Francis | Classical Heritage and European Identities | Routledge
    Publication Date: 2024-04-01
    Description: This book examines how different agents and institutions within the Danish nation state have situated themselves within this complex landscape of competing appropriations of classical antiquity from the eighteenth century to the present day. In particular, it focuses on the use of classical heritages to construct both European and national identities (in the plural) and especially on how Danes in this period have engaged with a sense of European commonality through their engagements with the classical past.
    Keywords: Classical heritage ; European identities ; Europe ; Danish nation ; Denmark ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 14
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    De Gruyter
    Publication Date: 2022-05-02
    Description: The future of area studies lies in opening out into TransArea studies, which tie together area-connected competencies with transdisciplinary research practices. It is one of the loftiest and most urgent duties of philology to lift up this treasure in the awareness of the special relevance of literature, and to make it democratically available to the broadest possible sections of the population.
    Keywords: Modern Languages and Linguistics ; Area Studies ; Literary Studies ; Literature ; History of Globalization ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFS Globalization
    Language: English
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  • 15
    Publication Date: 2024-04-01
    Description: This book is a reflection on the politics of heritage in Europe at the present time, in a moment of pluralised conceptions of the political, social and demographic organisation proper to Europe. It is not a book that seeks to survey, define or characterise an enduring ‘European heritage’ as an entity, but rather to explore what heritage does – how it is understood, instrumentalised and what it enables – within what we will argue is a ‘critical’ moment for both identities and geopolitics in Europe.
    Keywords: European heritage ; political organisation ; social organisation ; demographic organisation ; Europe ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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  • 16
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 17
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 18
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-08
    Description: The Orthodox Christian tradition has all too often been sidelined in conversations around contemporary religion. Despite being distinct from Protestantism and Catholicism in both theology and practice, it remains an underused setting for academic inquiry into current lived religious practice. This collection, therefore, seeks to redress this imbalance by investigating modern manifestations of Orthodox Christianity through an explicitly gender-sensitive gaze. By addressing attitudes to gender in this context, it fills major gaps in the literature on both religion and gender. Starting with the traditional teachings and discourses around gender in the Orthodox Church, the book moves on to demonstrate the diversity of responses to those narratives that can be found among Orthodox populations in Europe and North America. Using case studies from several countries, with both large and small Orthodox populations, contributors use an interdisciplinary approach to address how gender and religion interact in contexts such as, iconography, conversion, social activism and ecumenical relations, among others. From Greece and Russia to Finland and the USA, this volume sheds new light on the myriad ways in which gender is manifested, performed, and engaged within contemporary Orthodoxy. Furthermore, it also demonstrates that employing the analytical lens of gender enables new insights into Orthodox Christianity as a lived tradition. It will, therefore, be of great interest to scholars of both Religious Studies and Gender Studies.
    Keywords: Gender, Identity ; Christianity ; Women ; Religious ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVP Religious life and practice::QRVP7 Religious aspects of sexuality, gender and relationships ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVP Religious life and practice::QRVP7 Religious aspects of sexuality, gender and relationships ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities
    Language: English
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  • 19
    Publication Date: 2024-04-05
    Description: Polymer Engineering focuses on the preparation and application of polymers in several hot topics such as artificial photosynthesis, water purification by membrane technologies, and biodiesel production from wastewater plants. The authors not only describe the latest developments in polymer science, but also support these experimental results by computational chemistry and modelling studies.
    Keywords: QD1-999 ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 20
    Publication Date: 2024-04-05
    Keywords: B1-5802 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: German
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  • 21
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    Taylor & Francis | Environmental Policy in the EU | Routledge
    Publication Date: 2023-09-12
    Description: The European Union (EU) has a hugely important effect on the way in which environmental policies are framed, designed and implemented in many parts of the world, but especially Europe. The new edition of this leading textbook provides a state-of-the-art analysis of the EU’s environmental policies. Comprising five parts, Environmental Policy in the EU covers the rapidly changing context in which EU environmental policies are made, the key actors who interact to co-produce them and the most salient dynamics of policy making, ranging from agenda setting and decision making, through to implementation and evaluation. Written by leading international experts, individual chapters examine how the EU is responding to a multitude of different challenges including biodiversity loss, climate change, energy insecurity, and water and air pollution. They tease out the different ways in which the EU’s policies on these topics co-evolve with national and international environmental policies. In this systematically updated fourth edition, a wider array of learning features are employed to ensure that readers fully understand how EU environmental policies have developed over the last fifty years and how they are currently adapting to the rapidly evolving challenges of the twenty-first century, including the COVID-19 pandemic. It is an essential resource for undergraduate and postgraduate students studying environmental policy and politics, climate change, environmental law and EU politics more broadly.
    Keywords: Brexit; Climate Change; Energy security; Europe; European Union; European Parliament; Governance; Global Environmental Policy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNK Environment, transport & planning law::LNKJ Environment law ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNC Applied ecology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RND Environmental policy & protocols
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  • 22
    Publication Date: 2024-04-04
    Description: The southeastern Land of Seven Rivers (Kazakhstan) – a small region in the Eurasian steppes – shows an enormous concentration of Bronze and early Iron Age archeological monuments, only a small fraction of which have been described by researchers. This study, the first comprehensive investigation of these monuments, also makes an important contribution to knowledge about the historical – cultural evolution of the region.
    Keywords: CC1-960 ; D51-90 ; Kurgans ; Scythians ; Kazakhstan ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: German
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  • 23
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 24
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-14
    Description: This book introduces a new mechanism for representing social networks in which pairwise relationships can be drawn from a range of realistic possibilities, including different types of relationships, different strengths in the directions of a pair, positive and negative relationships, and relationships whose intensities change with time. For each possibility, the book shows how to model the social network using spectral embedding. It also shows how to compose the techniques so that multiple edge semantics can be modeled together. The modeling techniques are then applied to a range of datasets to show how they can produce results that are useful in understanding real-world social networks.
    Keywords: Computer Science ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics::UBW Internet: general works
    Language: English
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  • 25
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Language: English
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  • 26
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 27
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 28
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 29
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 30
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    De Gruyter
    Publication Date: 2024-03-25
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French , German
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  • 31
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 32
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: E-commerce offers immense challenges to traditional dispute resolution methods, as it entails parties often located in different parts of the world making contracts with each other at the click of a mouse. The use of traditional litigation for disputes arising in this forum is often inconvenient, impractical, time-consuming and expensive due to the low value of the transactions and the physical distance between the parties. Thus modern legal systems face a crucial choice: either to adopt traditional dispute resolution methods that have served the legal systems well for hundreds of years or to find new methods which are better suited to a world not anchored in territorial borders. Online Dispute Resolution (ODR), originally an off-shoot of Alternative Dispute Resolution (ADR), takes advantage of the speed and convenience of the Internet, becoming the best, and often the only option for enhancing consumer redress and strengthening their trust in e-commerce. This book provides an in-depth account of the potential of ODR for European consumers, offering a comprehensive and up to date analysis of the development of ODR. It considers the current expansion of ODR and evaluates the challenges posed in its growth. The book proposes the creation of legal standards to close the gap between the potential of ODR services and their actual use, arguing that ODR, if it is to realise its full potential in the resolution of e-commerce disputes and in the enforcement of consumer rights, must be grounded firmly on a European regulatory model. Introduction 1. Consumer Protection and Access to Justice in the E-Commerce Era: A European Perspective 2. Online Dispute Resolution as a Consumer Redress Strategy 3. Consumer Adjudicative Processes Supported by ICT: Court Processes and Arbitration 4. Online Mediation for Consumers: The Way Forward 5. The Need for a Legal Framework to Develop Consumer ODR in the EU
    Keywords: law ; dispute resolution ; information technology ; e-commercie ; information technology law ; commercial law ; e-commerce ; commercieel recht ; informatie technologie ; informatie technologie recht ; recht ; Alternative dispute resolution ; Arbitration ; Consumer protection ; European Union ; Mediation ; Online dispute resolution ; Uniform Domain-Name Dispute-Resolution Policy ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNT Media, information & communication industries::KNTX Information technology industries ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law::LNCB2 E-commerce law
    Language: English
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  • 33
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 34
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 35
    Publication Date: 2022-01-31
    Keywords: DD1-905
    Language: German
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  • 36
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 37
    Publication Date: 2024-04-08
    Description: As part of the German Jewish Cultural Heritage project, the expert contributors to this volume examine the cultural influence of the German-speaking Jewish intelligentsia around the world. This influence continues to be felt in many countries of origin and exile without being adequately reflected in collective consciousness. This volume makes a substantive contribution to the search for traces of German-speaking Jewish culture in the wake of emigration.
    Keywords: BM1-990 ; Emigration Judaism Jewish identity cultural heritage cultural history ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: German
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  • 38
    Publication Date: 2024-03-25
    Description: In welcher Weise und in welchem Maß haben die Ergebnisse des Newtonschen Experiments der Farbbrechung Einfluss auf die Bildende Kunst des 18. und 19. Jahrhunderts genommen? Diese Fragen stehen im Zentrum der Beiträge, welche die Malpraxis, die Theoriebildung zur Farbe, die neuen graphischen Reproduktionstechniken, die steigende Sehkompetenz, die Materialität von Farbe, die Verfeinerung der Darstellungsdetails und die Rolle optischer Instrumente untersuchen. Die Irritation im 18. Jahrhundert entstand aus der nicht eindeutigen Trennung in Licht- und Pigmentfarben. Für die Künstler hatte die alte Farbtrias - Blau, Rot, Gelb - weiterhin Bestand. Nichtsdestotrotz ist eine Verfeinerung des Sehens zu konstatieren, wie zunehmende Differenzierungskompetenz, die nicht nur neue graphische Techniken hervorbrachte, die im 19. Jahrhundert zur Fotographie führen sollten, sondern auch die Ästhetisierung verstärkte. Beiträge von: Ulrike Boskamp, Werner Busch, Erna Fiorentini, John Gage, Bettina Gockel, Ursula Klein, Carolin Meister, Jutta Müller-Tamm, Annik Pietsch, H. Otto Sibum, Monika Wagner, Marc Wellmann.
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 39
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
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  • 40
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 41
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 42
    Publication Date: 2022-01-31
    Keywords: PT1-4897
    Language: German
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  • 43
    Publication Date: 2024-04-08
    Description: This volume includes both historical treatments of differing German-Jewish understandings of their experience – their relations to their Judaism, general culture and to other Jews – and contemporary reflections and competing interpretations as to how to understand the overall experience of German Jewry.
    Keywords: BM1-990 ; DD1-905 ; German-Jewish Intellectuals Jewish Modernity ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
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  • 44
    Publication Date: 2024-04-01
    Description: The year 2014 saw the 200th anniversary of Napoleon's downfall - and the restauration of the French monarchy under the house of Bourbon. With this as a starting point, Volker Sellin shows how the European monarchies restored and prolonged their reigns by giving their countries constitutions. This new angle results in an astonishing history of the 19th century in Europe from Spain to Russia.
    Keywords: D204-475 ; political legitimacy ; legal history ; constitutions ; Restauration ; monarchies ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
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  • 45
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 46
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 47
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: The Gender-Sensitive University explores the prevailing forces that pose obstacles to driving a gender-sensitive university, which include the emergence of far-right movements that seek to subvert advances towards gender equality and managerialism that promotes creeping corporatism. This book demonstrates that awareness of gender equality and gender sensitivity are essential for pulling contemporary academia back from the brink. New forms of leadership are fundamental to reforming our institutions. The concept of a gender-sensitive university requires re-envisioning academia to meet these challenges, as does a different engagement of men and a shift towards fluidity in how gender is formulated and performed. Academia can only be truly gender-sensitive if, learning from the past, it can avoid repeating the same mistakes and addressing existing and new biases. The book chapters analyse these challenges and advocate the possibilities to ‘fix it forward’ in all areas. Representing ten EU countries and multiple disciplines, contributors to this volume highlight the evidence of persistent gender inequalities in academia, while advocating a blueprint for addressing them. The book will be of interest to a global readership of students, academics, researchers, practitioners, academic and political leaders and policy makers who share an interest in what it takes to establish gender-sensitive universities.
    Keywords: EU ; Europe ; GEPs ; gender ; equality ; university ; gender bias ; inequality ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
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  • 48
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    Taylor & Francis | International Perspectives on Writing Curricula and Development | Routledge
    Publication Date: 2023-09-12
    Description: This chapter analyses how writing and writing development has been and currently is prescribed and enacted in the curriculum for Danish as a subject (L1) in Years 1–9. Highlighting historical points of impact for writing in curricula from the early–nineteenth century through frequent reforms in the twentieth and twenty-first centuries, we focus empirically on the 2014 ruling curricular document Common Standards and auxiliary documents framing writing assessment at the school-leaving exam, as well as empirical classroom studies. Analyses of steering documents indicate that there has been an unprecedented push towards outcome-based and competence-oriented writing curricula. Following Ivanič's Discourses of Writing (DoW) framework, process writing is found to be the most dominant discourse from Grades 1–7. The analysis of the enacted writing curriculum, which focuses on empirical studies from 2009 until now, reveals that the enacted curriculum is misaligned with the prescriptive curriculum and tends to position the student in ambiguous ways—from joyful writer to a writer tested in high-stakes exams. For discussion, we call for a more coherent writing curriculum. Methodologically, we argue that the DoW framework needs to be complemented with a Nordic Bildung tradition, which accentuates personal formation, and a multimodal framework informing the Danish curriculum.
    Keywords: writing studies, writing development, cross-national writing research, school writing, curricular analysis, curriculum, assessment tools, national education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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  • 49
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
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  • 50
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 51
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
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  • 53
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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    De Gruyter
    Publication Date: 2024-03-27
    Description: To honor the 20th year of his reign, Emperor Constantine was given what may be the most precious gift of his lifetime: a codex of artistic panegyrics and odes dedicated to him by the poet Optatianus. Optatianus’ poems showcase the poetic talent of their creator and go beyond the classical confines of a panegyric: they form a literary invitation to an intellectual bond between laudator and laudandus.
    Keywords: Panegyric ; Visual poetry ; Late Antiquity ; Performativity ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: German
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  • 56
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
    Language: English
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  • 57
    Publication Date: 2023-09-12
    Description: The Routledge Handbook of International Human Rights Law provides the definitive global survey of the discipline of international human rights law. Each chapter is written by a leading expert and provides a contemporary overview of a significant area within the field. As well as covering topics integral to the theory and practice of international human rights law the volume offers a broader perspective though examinations of the ways in which human rights law interacts with other legal regimes and other international institutions, and by addressing the current and future challenges facing human rights. Providing up-to-date and authoritative articles covering key aspects of international human rights law, this book work is an essential work of reference for scholars, practitioners and students alike. Chapter 35 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9780203481417.ch35
    Keywords: books by Nigel Rodley ; counter-terrorism and human rights ; economic, social and cultural rights ; human rights enforcement ; International criminal law and human rights ; International trade and human rights ; international human rights ; international human rights law ; investment and human rights ; Nigel Rodley ; non-State actors and human rights ; UN and human rights ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
    Language: English
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  • 59
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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  • 61
    Publication Date: 2022-02-01
    Description: acques Derrida’s extensive early writings devoted considerable attention to “being as presence,” the reality underlying the history of metaphysics. In Derrida on Being as Presence: Questions and Quests, David A. White develops the intricate conceptual structure of this notion by close exegetical readings drawn from these writings. White discusses cardinal concepts in Derrida’s revamping of theoretical considerations pertaining to language–signification, context, negation, iterability–as these considerations depend on the structure of being as presence and also as they ground “deconstructive” reading. White’s appraisal raises questions invoking a range of problems. He deploys these questions in conjunction with thematically related quests that arise given Derrida’s conviction that the history of metaphysics, as variations on being as presence, has concealed and skewed vital elements of reality. White inflects this critical apparatus concerning being as presence with texts drawn from that history–e.g., by Plato, Aristotle, Bacon, Hume, Kant, Whitehead. The essay concludes with a speculative ensemble of provisional categories, or zones of specificity. Implementing these categories will ground the possibility that philosophy in general and metaphysics in particular can be pursued in ways which acknowledge the relevance of Derrida’s thought when integrated with the philosophical enterprise as traditionally understood.
    Keywords: BC1-199 ; B1-5802
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    Publication Date: 2022-01-31
    Description: Despite the richness of its facets, the short religious epic has been largely neglected by scholars until now. This study explores this literary phenomenon using a multi-perspectival descriptive model. Extensive detailed case studies provide basic information and present the genre in its broader literary historical and systematic context.
    Keywords: PT1-4897 ; short epic ; classification of texts ; Middle High German literature ; religious literature
    Language: German
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: "This book offers multidisciplinary perspectives on renewable economies in the Arctic and how these are being supported scientifically, economically, socially, and politically by Arctic states. The economic development of the Arctic region is witnessing new, innovative trends which hold promise for the sustainable development of the region. This book discusses the emerging forms of renewable economies to understand where intellectual and technological innovations are being made. It draws on the expertise of scholars from across the Arctic and provides the reader with a foundation of knowledge to identify the unique challenges of the region and explore opportunities to unlock the immense potential of renewable resources to boost the region’s economy. This book offers a holistic Arctic perspective against the backdrop of prevailing social, economic, and climatic challenges. With critical insights on the economic state of play and the role of renewable resources in the development of the Arctic region, this book will be a vital point of reference for Arctic scholars, communities, and policy makers."
    Keywords: Geography;Human geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography
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    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Publication Date: 2024-04-01
    Description: This volume is an investigation of how Augustine was received in the Carolingian period, and the elements of his thought which had an impact on Carolingian ideas of ‘state’, rulership and ethics. It focuses on Alcuin of York and Hincmar of Rheims, authors and political advisers to Charlemagne and to Charles the Bald, respectively. It examines how they used Augustinian political thought and ethics, as manifested in the De civitate Dei, to give more weight to their advice. A comparative approach sheds light on the differences between Charlemagne’s reign and that of his grandson. It scrutinizes Alcuin’s and Hincmar’s discussions of empire, rulership and the moral conduct of political agents during which both drew on the De civitate Dei, although each came away with a different understanding. By means of a philological–historical approach, the book offers a deeper reading and treats the Latin texts as political discourses defined by content and language.
    Keywords: Augustine ; De Civitate Dei ; Rulership ; Alcuin ; Hincmar ; Early medieval Europe ; Carolingian ; Ethics ; Political thought ; Charlemagne ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    De Gruyter
    Publication Date: 2024-04-04
    Description: An increasing complexity of models used to predict real-world systems leads to the need for algorithms to replace complex models with far simpler ones, while preserving the accuracy of the predictions. This two-volume handbook covers methods as well as applications. This second volume focuses on applications in engineering, biomedical engineering, computational physics and computer science.
    Keywords: Applied mathematics ; PROM ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBK Calculus and mathematical analysis::PBKS Numerical analysis ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHU Mathematical physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering
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  • 68
    Publication Date: 2022-02-01
    Description: Zentrales Thema des Sammelbandes ist der Begriff der Verfestigung bzw. der formalen Stabilität im Deutschen und im Sprachvergleich, der die Aktualität der neueren lexikographischen und phraseologischen Forschung besonders prägt. Die hier versammelten 23 Beiträge reihen sich thematisch in diese Aktualität ein und behandeln diskursive Aspekte der Verfestigungs- bzw. Stabilitätsproblematik im Diskurs. Arbeiten und Forschungsergebnisse ausgewiesener internationaler Experten werden hier zusammengefu?hrt, die sich der Schnittstelle zwischen Pragmatik und Morphologie/Syntax widmen und vor allem das Deutsche oder den Sprachvergleich betreffende Fragestellungen im Zusammenhang mit Grammatikalisierungs-, Lexikalisierungs- und/oder Phraseologisierungsphänomenen diskutieren. Hiermit verbunden wird u.a. der Frage nachgegangen, wie verfestigte Strukturen zu Argumentationszwecken im Diskurs eingesetzt werden. Der vier thematische Bereiche umfassende Band zeigt damit, wie facettenreich der Verfestigungsbegriff im Diskurs sein kann und bietet zugleich Impulse fu?r die ku?nftige Forschung in diesem Bereich.
    Keywords: P1-1091 ; Discourse ; Phraseology ; Lexicalization ; Grammaticalization
    Language: German
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World
    Keywords: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: This book provides a comparative and transnational examination of the complex and multifaceted experiences of anti-labour mobilisation, from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. It retraces the formation of an extensive market for corporate policing, privately contracted security and yellow unionism, as well as processes of professionalisation in strikebreaking activities, labour espionage and surveillance. It reconstructs the diverse spectrum of right-wing patriotic leagues and vigilante corps which, in support or in competition with law enforcement agencies, sought to counter the dual dangers of industrial militancy and revolutionary situations. Although considerable research has been done on the rise of socialist parties and trade unions the repressive policies of their opponents have been generally left unexamined. This book fills this gap by reconstructing the methods and strategies used by state authorities and employers to counter outbreaks of labour militancy on a global scale. It adopts a long-term chronology that sheds light on the shocks and strains that marked industrial societies during their turbulent transition into mass politics from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. Offering a new angle of vision to examine the violent transition to mass politics in industrial societies, this is of great interest to scholars of policing, unionism and striking in the modern era.
    Keywords: Armed Associations ; Austria-Hungary ; Czarism ; Dublin Lockout ; Geoff Eley ; Iberian Peninsula ; Industrial vigilantism ; Proto-Fascism ; Russian Empire ; The Dark Side of the Belle Époque ; Tsarism ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
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    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Taylor & Francis | Changing Paradigms and Approaches in Interpreter Training | Routledge
    Publication Date: 2024-03-24
    Description: The aim of the chapter is to determine whether the current education of interpreters in the Republic of Slovenia responds to the needs of the society. In order to do that, the chapter first briefly outlines the development of the education of Slovene interpreters from its beginnings to the present. By drawing on the results of a nation-wide survey of language-support needs in Slovene healthcare institutions from 2016, which gathered responses of 564 healthcare workers, and on statistics of the Ministry of Interior Affairs of the Republic of Slovenia providing the countries of origin of applicants for international protection in Slovenia in the period between 2013 and 2019, the language needs on the contemporary Slovene society are outlined. These needs are then compared to the results provided by a nation-wide survey of interpreters and sworn interpreters from 2020 (n=123) focusing on language combinations they offer and identifying different settings in which they work. The results of this comparison show that there is a serious mismatch between the needs of the society and the existing language profiles of professional interpreters in the market, which results in the fact that ad-hoc interpreters are used for almost all the languages of newly arrived migrants with negative consequences for society at large. The chapter concludes with the description of educational efforts aimed at remedying the situation: first, a short specialisation program for sworn interpreters introduced in 2018, and second, the education of teachers of community interpreters for Albanian, Arabic and Persian which took place from 2019 to 2020.
    Keywords: Interpreting studies; community interpreting; community interpreter education; interpreting in Slovenia; Slovenia ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general
    Language: English
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    De Gruyter | De Gruyter Oldenbourg
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 76
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
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  • 77
    Publication Date: 2023-12-20
    Description: This volume contains presentations and discussions from the Conference of the Association of German Constitutional Lawyers, which was held in Düsseldorf from 1 to 4 October 2014.
    Keywords: K1-7720 ; constitutional law ; fundamental rights ; democracy ; bic Book Industry Communication::L Law
    Language: German
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  • 78
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 79
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 80
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 81
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    Taylor & Francis | Negotiating bioethics | Routledge
    Publication Date: 2024-04-05
    Description: The sequencing of the entire human genome has opened up unprecedented possibilities for healthcare, but also ethical and social dilemmas about how these can be achieved, particularly in developing countries. UNESCO's Bioethics Programme was established to address such issues in 1993. Since then, it has adopted three declarations on human genetics and bioethics (1997, 2003 and 2005), set up numerous training programmes around the world and debated the need for an international convention on human reproductive cloning. Negotiating Bioethics presents Langlois' research on the negotiation and implementation of the three declarations and the human cloning debate, based on fieldwork carried out in Kenya, South Africa, France and the UK, among policy-makers, geneticists, ethicists, civil society representatives and industry professionals. The book examines whether the UNESCO Bioethics Programme is an effective forum for (a) decision-making on bioethics issues and (b) ensuring ethical practice. Considering two different aspects of the UNESCO Bioethics Programme - deliberation and implementation - at international and national levels, Langlois explores: - how relations between developed and developing countries can be made more equal - who should be involved in global level decision-making and how this should proceed - how overlap between initiatives can be avoided - what can be done to improve the implementation of international norms by sovereign states - how far universal norms can be contextualized - what impact the efficacy of national level governance has at international level Drawing on extensive empirical research, Negotiating Bioethics presents a truly global perspective on bioethics
    Keywords: unesco's bioethics programm ; bioethics ; genetics, medical ; program evaluation ; ethics, medical ; international cooperation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics
    Language: English
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  • 82
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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  • 83
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
    Language: English
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  • 84
    Publication Date: 2024-03-25
    Description: Die sächsische Lebensgeschichte des Historikers Karl Buchheim ist eine dichtbelegte Schilderung unterschiedlicher Perioden der deutschen Geschichte im 20. Jahrhundert. Sie dokumentiert den Werdegang Buchheims vom Schüler zum Münchner Hochschullehrer und die Entwicklung seines Geschichtsbildes. Karl Buchheim plädierte mit Nachdruck für die Revision des herrschenden kleindeutschen Geschichtsbildes und erwies sich damit als entschiedener Kritiker Bismarcks und Luthers.
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 85
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 86
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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  • 87
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 88
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 89
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 90
    Publication Date: 2024-03-24
    Description: This synchronic study presents a new onomasiological, frame-theoretical model for the description, classification and theoretical analysis of the cross-linguistic content category aspectuality. It deals specifically with those pieces of information, which, in their interplay, constitute the aspectual value of states of affairs. The focus is on Romance Languages, although the model can be applied just as well to other languages, in that it is underpinned by a principle grounded in a fundamental cognitive ability: the delimitation principle. Unlike traditional approaches, which generally have a semasiological orientation and strictly adhere to a semantic differentiation between grammatical aspect and lexical aspect (Aktionsart), this study makes no such differentiation and understands these as merely different formal realisations of one and the same content category: aspectuality.
    Keywords: P1-1091 ; Aspectuality ; Onomasiology ; thema EDItEUR::C Language and Linguistics
    Language: English
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  • 91
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    Taylor & Francis | The Routledge Handbook of Philosophy and Improvisation in the Arts | Routledge
    Publication Date: 2024-04-05
    Description: The idea of improvisation, broadly defined, has been integral to our imagination of the medieval musical past. It can be related to many elements of production: to the act of un-notated creation; to the manipulation and amplification of notated materials; to our observance of rigid rules and formulae; or to spontaneous freedom. Likely a product of the Carolingian Renaissance, this is the first medieval music treatise to address an aspect of chant performance that does not only relate to a memorized repertoire, but includes an unwritten practice of extemporizing an accompanying voice to a pre-given melody. The art of “coloration” or the ornamentation of a line, whether polyphonic or monophonic, had been an integral part of extemporization since at least the time of the Ad organum faciendum treatises. When planning author's ontological inquiries, the author's would do well to remember the possible existence of creativity that is not inspired, or ephemerality that is not performer- or expression-centered.
    Keywords: Philosophy, Ontology, Music, Improvisation, Arts, Performance ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 92
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 93
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 94
    Publication Date: 2024-03-25
    Description: Die Geschichte der römischen Kaiser wurde im 20. Jahrhundert von der seriösen Historiographie meist vernachlässigt. Die in diesem Band versammelten Aufsätze loten die Möglichkeiten einer neuen, strukturgeschichtlich fundierten und personalistische Erklärungsmuster vermeidenden Kaisergeschichte aus. Behandelt werden die Quellenproblematik, die strukturellen Bedingungen kaiserlicher Handlungsfelder und die biographische Forschung zu den Kaisern von Augustus bis Commodus (31 v. Chr. &#8211 192 n. Chr.). Beiträge von Christer Bruun, Olivier Hekster, Ralf von den Hoff, Martin Hose, Christian Ronning, Dirk Schnurbusch, Gunnar Seelentag, Dieter Timpe, Uwe Walter, Aloys Winterling, Christian Witschel, Martin Zimmermann.
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 95
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    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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  • 96
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: This book investigates the ways in which soft power is used by African countries to help drive global influence. Selecting four of the countries most associated with soft power across the continent, this book delves into the currencies of soft power across the region: from South Africa’s progressive constitution and expanding multinational corporations, to Nigeria’s Nollywood film industry and Technical Aid Corps (TAC) scheme, Kenya’s sport diplomacy, fashion and tourism industries, and finally Egypt’s Pan-Arabism and its reputation as the cradle of civilisation. The book asks how soft power is wielded by these countries and what constraints and contradictions they encounter. Understandings of soft power have typically been driven by Western scholars, but throughout this book, Oluwaseun Tella aims to Africanise our understanding of soft power, drawing on prominent African philosophies, including Nigeria’s Omolúwàbí, South Africa’s Ubuntu, Kenya’s Harambee, and Egypt’s Pharaonism. This book will be of interest to researchers from across political science, international relations, cultural studies, foreign policy and African Studies.
    Keywords: African Studies ; cultural studies ; foreign policy ; international relations ; political science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies
    Language: English
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  • 97
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    De Gruyter
    Publication Date: 2024-03-29
    Description: Anhand neuer Quellen werden die Berliner 'jüdischen Salons' um 1800 als ebenso lebendiges wie fragiles kommunikatives Netz präsentiert. Der Querschnitt durch die Salongesellschaft des Beispieljahrs 1794/95 beleuchtet eine Geselligkeitskultur, in der verschiedene Orte zu Salons wurden. Längsschnitte durch jahrzehntelang geführte Korrespondenzen erlauben die Frage nach Wechselwirkungen zwischen Salons und zeitgenössischen Emanzipationsdiskursen.
    Keywords: Jewish Studies ; Europe ; Germany ; HIS022000 ; History ; Jewish ; LIT004210 ; SOC049000 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: English
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  • 98
    Publication Date: 2024-03-25
    Description: Der Rifkrieg (1921-1926) in Nordmarokko ist von der deutschen Geschichtsschreibung nur wenig beachtet worden, und dies obwohl Deutschland in vielfältiger Weise an den Geschehnissen beteiligt war. Mohammed ben Abdelkrim el Khattabi alias Abdelkrim schaffte es, die zerstrittenen Rifkabylen zu vereinen und aus der Widerstandsbewegung gegen die spanischen Invasoren die 1923 proklamierte "Rif-Republik" erwachsen zu lassen. Dirk Sasse geht den deutschen, britischen und französischen Helfern Abdelkrims nach – Ärzten, Technikern usw. –, die zu einer schleichenden Verlängerung des Krieges beitrugen, aber auch bei der vorgesehenen Modernisierung des Landes mithelfen sollten. Sein Buch ist ein Beitrag zur Geschichte der Dekolonisation und zur Geschichte der Vernetzung zwischen der außereuropäischen Bevölkerung und antikolonial eingestellten Sympathisanten in Europa.
    Keywords: D1-2009 ; DAW1001-1051 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 99
    Publication Date: 2023-09-12
    Description: This book brings together researchers from the fields of international human rights law, EU law and constitutional law to reflect on the tug-of-war over the positioning of the centre of gravity of human rights protection in Europe. It addresses both the position of the Convention system vis-à-vis the Contracting States, and its positioning with respect to fundamental rights protection in the European Union. The first part of the book focuses on interactions in this triangle from an institutional and constitutional point of view and reflects on how the key actors are trying to define their relationship with one another in a never-ending process. Having thus set the scene, the second part takes a critical look at the tools that have been developed at European level for navigating these complex relationships, in order to identify whether they are capable of responding effectively to the complexities of emerging realities in the triangular relationship between the EHCR, EU law and national law. Chapter 10 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781138121249_oachapter10.pdf
    Keywords: accession ; agreement ; court ; draft ; european ; geir ; judgment ; pilot ; procedure ; ulfstein ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::L Law::LB International law ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPV Political control & freedoms::JPVH Human rights
    Language: English
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  • 100
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    De Gruyter
    Publication Date: 2024-03-24
    Description: The 2013 Annual of the Institute for the German Language provides a classification of discourse on language decline based on language history and variation linguistics. In addition, it offers an analysis of the processes underlying the public debate from the perspectives of language sociology.
    Keywords: Language ; language decline ; language change ; thema EDItEUR::C Language and Linguistics
    Language: German
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