ISSN:
0570-0833
Keywords:
Isoureas
;
Alkylation
;
Carbodiimides
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The CuCl2-catalysed addition of alcohols to aliphatic caribodiimides (particularly diisopropylcarbodiimide) to form O,N,N′-trialkylisoureas may, in the case of bifunctional hydroxy compounds (esters of α-hydroxycarboxylic acids, diols, halogeno alcohols, amino alcohols, and cyclic hydroxy ethers), continue to give 5-, 6-, and 7-membered 1,3-O,N or 1,3-N,N heterocycles. O,N,N′-Trialkylisoureas are selective alkylating agents. Thus alcohols with allyl structures can be etherified with diisopropylcarbodiimide; a new method of esterification via O,N,N′-trialkylisoureas has been applied to mesitylenecarboxylic acid.
Additional Material:
8 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.196604701
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