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  • United States  (126)
  • Structure-Activity Relationship  (39)
  • American Association for the Advancement of Science (AAAS)  (164)
  • Nature Publishing Group
  • 1980-1984  (164)
  • 1935-1939
  • 1982  (75)
  • 1981  (89)
  • 1939
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (164)
  • Nature Publishing Group
Years
  • 1980-1984  (164)
  • 1935-1939
Year
  • 1
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    GABA analogues activate channels of different duration on cultured mouse spinal neurons (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-17
    Description: Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Mathers, D A -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects ; Ion Channels/*drug effects ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects ; Receptors, Cell Surface/metabolism ; Receptors, GABA-A ; Spinal Nerves/*drug effects ; Structure-Activity Relationship ; Time Factors ; gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    National Science Foundation budgets: fiscal years 1982, 1982, and beyond (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branscomb, L M -- New York, N.Y. -- Science. 1981 May 1;212(4494):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209546" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; Budgets ; Cognition ; Economics ; Engineering/economics ; Forecasting ; *Government Agencies ; Research Support as Topic/*economics ; Social Sciences/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Fraud and the structure of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1981 Apr 10;212(4491):137-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209527" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Fraud ; National Institutes of Health (U.S.) ; *Research ; Social Control, Formal ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Cancer researchers defend NCI against congressional attacks (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):117.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244625" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; National Institutes of Health (U.S.)/*organization & administration ; *Neoplasms ; *Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Science and the universities (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: The university system in Canada, as well as its method of funding, was built on the expectation of growth. It is now necessary to consider what effect the expected decline in enrollment may have on the ability of the university system to serve national needs. Neither the government nor the universities have had any experience that would fit them for carrying out effectively, humanly, and economically the kind of contraction that may be required, while still maintaining the quality of education. Such an adjustment is going to require the best efforts of the universities and the two senior levels of government working in concert, as well as the support of the public. Parallels are drawn with the situation in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fortier, C -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1065-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268413" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; *Science ; United States ; Universities/manpower/*trends
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Multiple opiate receptors: alcohol selectively inhibits binding to delta receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: The addition of ethanol or other aliphatic alcohols to rat brain membranes strongly inhibits binding of enkephalins at concentrations at which little inhibition of opiate alkaloids is seen. Inhibition is reversible, and potency increases with chain length of the alcohol. The results suggest that delta receptors are considerably more sensitive to alcohols than mu receptors. This is the first demonstration of selective inhibition of one of the postulated classes of opiate receptors by a reagent that is not a ligand for the receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiller, J M -- Angel, L M -- Simon, E J -- DA-00017/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270788" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohols/*pharmacology ; Animals ; Brain/metabolism ; Cells, Cultured ; In Vitro Techniques ; Neuroblastoma/metabolism ; Rats ; Receptors, Opioid/classification/*drug effects/metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Insulin as a potent, specific growth factor in a rat hepatoma cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Library of medicine versus private enterprise (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1125-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015508" target="_blank"〉PubMed〈/a〉
    Keywords: Industry ; *Information Services ; *Medlars ; *National Library of Medicine (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Asbestos surface charge heterogeneity and biological effects (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Light, W G -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280676" target="_blank"〉PubMed〈/a〉
    Keywords: *Asbestos ; Humans ; Occupational Diseases/chemically induced ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    FDA sees no radiation risk in VDT screens (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1120-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7248044" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Display ; Humans ; Radiation Injuries/*etiology ; Risk ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    A new wave of antibiotics builds (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302591" target="_blank"〉PubMed〈/a〉
    Keywords: *Cephalosporins/therapeutic use ; Humans ; Research ; Structure-Activity Relationship ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    FDA approves hepatitis B vaccine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302582" target="_blank"〉PubMed〈/a〉
    Keywords: Hepatitis B/*prevention & control ; Hepatitis B Surface Antigens/*standards ; Humans ; United States ; United States Food and Drug Administration ; *Vaccines
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Thymosin stimulates secretion of luteinizing hormone-releasing factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rebar, R W -- Miyake, A -- Low, T L -- Goldstein, A L -- AG-01531/AG/NIA NIH HHS/ -- HD-12303/HD/NICHD NIH HHS/ -- HD-14362/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):669-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7027442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gonadotropin-Releasing Hormone/*secretion ; Hormones/pharmacology ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamus/*drug effects ; Peptide Fragments/pharmacology ; Rats ; Structure-Activity Relationship ; Thymosin/*pharmacology ; Thymus Hormones/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Didemnins: antiviral and antitumor depsipeptides from a caribbean tunicate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-22
    Description: Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, didemnins A, B, and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at the lowest concentration in inhibiting viral replication in vitro and P388 leukemia in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rinehart, K L Jr -- Gloer, J B -- Hughes, R G Jr -- Renis, H E -- McGovren, J P -- Swynenberg, E B -- Stringfellow, D A -- Kuentzel, S L -- Li, L H -- AI 04769/AI/NIAID NIH HHS/ -- GM 27029/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):933-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibiotics, Antineoplastic/*isolation & purification ; Antiviral Agents/*isolation & purification ; *Depsipeptides ; Leukemia, Experimental/*drug therapy ; Peptides, Cyclic/*isolation & purification/therapeutic use ; Structure-Activity Relationship ; Urochordata/*analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    E. Margaret Burbidge, president-elect (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, V C -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):915-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008193" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; History, 20th Century ; Societies, Scientific/*history ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    The federal government's role in basic research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmitt, H -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444463" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Aspartame approved despite risks (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):986-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268411" target="_blank"〉PubMed〈/a〉
    Keywords: Aspartame/*standards ; Dipeptides/*standards ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    FDA plans action on sodium in foods (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1373.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233225" target="_blank"〉PubMed〈/a〉
    Keywords: *Food Handling ; Humans ; *Sodium ; United States ; *United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    OSHA shifts direction on health standards (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1482-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233234" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Government Agencies ; *Government Regulation ; *Health Policy ; Humans ; Occupational Diseases/*prevention & control ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Cancer institute passes first test in senate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1122.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233205" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; National Institutes of Health (U.S.) ; *Neoplasms ; Politics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Compensation for victims of vaccines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):906-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466364" target="_blank"〉PubMed〈/a〉
    Keywords: *Compensation and Redress ; Costs and Cost Analysis ; Disclosure ; Drug Industry/economics/*standards ; *Federal Government ; Humans ; Insurance ; *Jurisprudence ; Mandatory Programs ; Risk ; Risk Assessment ; United States ; Vaccines/*adverse effects ; Voluntary Programs
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Cancer institute's drug program reproved (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):887-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302567" target="_blank"〉PubMed〈/a〉
    Keywords: Disclosure ; Drug Evaluation/*standards ; Federal Government ; *Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; Politics ; Risk Assessment ; *Therapeutic Human Experimentation ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Reagan reforms create upheaval at NIOSH (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280688" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Occupational Medicine/*standards ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Institute, keratotomists don't see eye to eye (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):423-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244640" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; Myopia/*surgery ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 27
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    Hatch batters NCI with straus case (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015513" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Federal Government ; *Government Regulation ; History, 20th Century ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms ; Politics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 28
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    Amniocentesis: be prepared (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233217" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; *Amniocentesis ; Congenital Abnormalities/diagnosis ; Federal Government ; Female ; Humans ; Legislation, Medical ; Pregnancy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    Gold pipettes make for tight lips (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1368.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233223" target="_blank"〉PubMed〈/a〉
    Keywords: Ethics ; *Industry ; *Information Dissemination ; *Research ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 30
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    Gene therapy pioneer draws Mikadoesque rap (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6940246" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*therapeutic use ; Ethics Committees, Research ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; *Legislation, Medical ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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  • 31
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    Gene therapy caught in more entanglements (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259731" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *DNA, Recombinant ; *Ethics Committees, Research ; *Ethics, Medical ; Federal Government ; Female ; *Genetic Engineering/history ; Genetic Vectors ; Globins/genetics ; Government Regulation ; History, 20th Century ; Humans ; Informed Consent ; Israel ; Plasmids ; Thalassemia/*therapy ; United States
    Print ISSN: 0036-8075
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  • 32
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    Medical journal draws lancet on rival (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):561.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455694" target="_blank"〉PubMed〈/a〉
    Keywords: Information Services ; *Periodicals as Topic ; Publishing ; Research ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 33
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    Mouse pox threat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: A News and Comment Briefing ("OSHA backs away from strict lab rules," 28 Nov. 1980, p. 992) incorrectly quoted a National Research Council report on safe handling of laboratory chemicals as saying, "For most laboratory environments, ... regular monitoring of the airborne concentrations of a variety of different toxic materials is both unjustified and unjust." The report actually said it was "unjustified and impractical."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallace, G D -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):438.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6256854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Laboratory/*microbiology ; Disease Outbreaks/*veterinary ; Ectromelia virus ; Ectromelia, Infectious/*epidemiology ; Mice ; Mice, Inbred Strains ; Poxviridae Infections/*epidemiology ; Rodent Diseases/epidemiology ; United States
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  • 34
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    Carter transmits an interim budget (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455684" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; Financial Management/*legislation & jurisprudence ; Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Abortion and the limitations of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zack, B G -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):291.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244615" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Spontaneous ; *Beginning of Human Life ; *Embryo, Mammalian ; Female ; Humans ; *Jurisprudence ; *Life ; *Personhood ; Pregnancy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
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  • 37
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    Artificial enzymes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, R -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):532-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123255" target="_blank"〉PubMed〈/a〉
    Keywords: Catalysis ; Cyclodextrins ; *Enzymes ; Kinetics ; Models, Chemical ; Ribonucleases ; Structure-Activity Relationship ; Substrate Specificity ; Transaminases
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  • 38
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    Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: (+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their behavioral effects on squirrel monkeys and rats trained to discriminate phencyclidine from saline. Dose-response determinations were made for responses to phencyclidine, to a racemic mixture of N-allylnormetazocine, and to the pure levo and dextro isomers of N-allylnormetazocine. In both rats and monkeys, the dextro isomer and the racemic mixture produced dose-dependent responses appropriate for phencyclidine; the levo isomer did not produce the responses appropriate for phencyclidine at any of the doses tested. In both species, the levo isomer was more potent than the dextro isomer in decreasing the rate of responding. Thus racemic N-allylnormetazocine is a mixture of compounds that produce different behavioral effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brady, K T -- Balster, R L -- May, E L -- DA-00490/DA/NIDA NIH HHS/ -- DA-01442/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274022" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Male ; Naloxone/pharmacology ; Phenazocine/*analogs & derivatives/pharmacology ; Phencyclidine/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid/drug effects ; Saimiri ; Stereoisomerism ; Structure-Activity Relationship
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  • 39
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    NIH grapples with misconduct (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):227.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089558" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Ethics ; Federal Government ; *Fraud ; National Institutes of Health (U.S.) ; *Research ; United States ; a staff symposium held at the National Institutes of Health (NIH) in June 1982. ; Organized by William Raub, head of extramural research, the session covered such ; topics as when and to whom to report suspected data falsification, the legal ; liability of accusers and investigators in view of slander and libel laws, how to ; protect the rights of the accused, and sanctions against researchers found guilty ; of fraud. The reports resulting from the symposium will offer guidance not only ; to NIH staffers and study review committee members, but also to client ; universities and institutions.
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  • 40
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    OSHA policy on carcinogens (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, M D -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):884.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Humans ; Occupational Diseases/chemically induced ; United States ; *United States Occupational Safety and Health Administration
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  • 41
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 42
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    Heart study produces a surprise result (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):31-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123213" target="_blank"〉PubMed〈/a〉
    Keywords: Diuretics/*adverse effects ; Heart Diseases/*drug therapy ; Humans ; National Institutes of Health (U.S.) ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 43
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    Purinergic regulation of food intake (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, A S -- Morley, J E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Deoxyguanosine/pharmacology ; Diazepam/pharmacology ; Eating/*drug effects ; Food Deprivation ; Inosine/analogs & derivatives/pharmacology ; Insulin/pharmacology ; Male ; Muscimol/pharmacology ; Purines/*pharmacology ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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    Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-28
    Description: The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLaughlin, J A -- Anderson, R R -- Holick, M F -- AM 27334/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1001-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281884" target="_blank"〉PubMed〈/a〉
    Keywords: Cholecalciferol/*biosynthesis/metabolism ; Dehydrocholesterols/radiation effects ; Ergosterol/metabolism ; Humans ; In Vitro Techniques ; Isomerism ; Photochemistry ; Skin/*metabolism ; Spectrum Analysis ; Structure-Activity Relationship ; Ultraviolet Rays
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Index Medicus: essential tool (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nevill, A D -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750788" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; Costs and Cost Analysis ; MEDLARS/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Intellectual property: the control of scientific information (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-14
    Description: Control of scientific information is increasingly at the center of legal and administrative disputes, raising questions of sovereignty and secrecy, of proprietary rights over research. Disputes originate from efforts to extend the right of access to data at an early stage of research, from demands for information that threaten confidentiality, from proprietary interests in competitive areas of research, and from government restrictions on the free exchange of scientific ideas. They reflect policy changes with respect to information disclosure, university-industry collaboration, patent rights, and national security. A review of diverse situations that have led to disputes and of efforts to negotiate principles for controlling intellectual property suggests the problems of establishing such principles in the context of the changing role of science.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelkin, D -- New York, N.Y. -- Science. 1982 May 14;216(4547):704-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079728" target="_blank"〉PubMed〈/a〉
    Keywords: *Confidentiality ; Government ; Information Services/*supply & distribution ; Research ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    No fraud found in alcoholism study (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):771.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134972" target="_blank"〉PubMed〈/a〉
    Keywords: *Alcoholism ; *Behavioral Research ; Fraud ; Humans ; *Research ; United States ; allegations that they fabricated data in a project on treatment of alcoholics. ; Their research, which suggested that some alcoholics can reject abstinence and ; learn to moderate their drinking, was disputed by other researchers. The ; investigating committee did not judge whether alcoholics can indeed become ; moderate drinkers but concluded that the Sobells had carried out the research as ; reported except for one lapse ascribed to carelessness. The procedures of the ; committee, which was appointed by the Addiction Research Foundation where the ; Sobells are now employed, have been questioned by critics.
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    The risks of living near Love Canal (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):808-9, 811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100924" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemical Industry ; Humans ; *Industrial Waste ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Hawaiian milk problems stir little action (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):612-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896391" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Food Contamination ; Hawaii ; Heptachlor/pharmacology ; Milk ; United States ; United States Environmental Protection Agency ; United States Food and Drug Administration
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    Love Canal study attracts criticism (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):714-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100914" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Industry ; *Government Agencies ; *Industrial Waste ; United States ; *United States Environmental Protection Agency
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Education, science, and national economic competitiveness (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Opel, J R -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1116-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112117" target="_blank"〉PubMed〈/a〉
    Keywords: Education/*trends ; *Science ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    OSHA's new thoughts on cancer policy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089538" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; *Government Agencies ; Humans ; Neoplasms/chemically induced/*prevention & control ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    DNA rules kept to head off new laws (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063840" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Containment of Biohazards/*standards ; Federal Government ; *Government Regulation ; Mandatory Programs ; National Institutes of Health (U.S.) ; United States ; Voluntary Programs ; approved a proposal to loosen the NIH Guidelines on federally funded DNA research ; while keeping the rules mandatory. The committee rejected a proposal that would ; have made the guidelines completely voluntary out of fear that this action could ; lead to overly tight restriction by state and local governments. Committee ; members were also concerned about the potential risks of some gene-splicing ; experiments.
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    Oxytocin induces maternal behavior in virgin female rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, C A -- Ascher, J A -- Monroe, Y L -- Prange, A J Jr -- MH-22536/MH/NIMH NIH HHS/ -- MH-32316/MH/NIMH NIH HHS/ -- MH-34933/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):648-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine Vasopressin/pharmacology ; Brain/physiology ; Female ; Injections, Intraventricular ; *Maternal Behavior ; Oxytocin/administration & dosage/*pharmacology ; Rats ; Structure-Activity Relationship
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    EPA issues hazardous waste rules (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):430.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896388" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Pollutants ; Facility Regulation and Control/*standards ; *Refuse Disposal ; United States ; United States Environmental Protection Agency ; Waste Products
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    Information services (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willard, R S -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):586.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046054" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government/economics ; Information Services/*economics ; MEDLARS/economics ; *National Library of Medicine (U.S.) ; United States
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    Translational efficiency of transfer RNA's: uses of an extended anticodon (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarus, M -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):646-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753149" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Escherichia coli/genetics ; Kinetics ; Nucleic Acid Conformation ; *Protein Biosynthesis ; RNA, Transfer/*genetics ; Ribosomes/metabolism ; Structure-Activity Relationship ; Suppression, Genetic
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    Effectiveness of psychotherapy (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bordin, E S -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):394-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244638" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; National Institutes of Health (U.S.) ; *Psychotherapy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    AAAS officers, staff, committees, and representatives for 1981 (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Feb 27;211(4485):925-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008194" target="_blank"〉PubMed〈/a〉
    Keywords: *Directories as Topic ; *Societies, Scientific ; United States
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    Love Canal (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Jan 2;211(4477):8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6893760" target="_blank"〉PubMed〈/a〉
    Keywords: New York ; State Health Planning and Development Agencies ; United States ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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    Team research: responsibility at the top (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):114-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244624" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Ethics ; Humans ; Moral Obligations ; *Research ; *Social Responsibility ; United States
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    Research in EPA: A congressional point of view (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: From lessons learned in several years of overseeing the research programs of the Environmental Protection Agency, the authors conclude that the agency should give more support to the accumulation of the scientific "intellectual capital" needed for managing the environment in the long term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, G E Jr -- Byerly, R Jr -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466395" target="_blank"〉PubMed〈/a〉
    Keywords: Environment ; *Government Agencies ; *Research ; Research Support as Topic ; United States
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    Age at menarche: a misunderstanding (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bullough, V L -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):365-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017929" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Age Factors ; Child ; England ; Female ; *History of Medicine ; History, 19th Century ; History, 20th Century ; History, Medieval ; Humans ; *Menstruation ; United States
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    Fredrickson resigns for NIH (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):111-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017930" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; National Institutes of Health (U.S.)/*organization & administration ; United States
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    Hatch on NCI hearings (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hatch, O G -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):392.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244636" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *National Institutes of Health (U.S.) ; *Neoplasms ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Hayes intends modest reforms at FDA. Interview by R. Jeffery Smith (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, A Jr -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):984-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268410" target="_blank"〉PubMed〈/a〉
    Keywords: Pharmaceutical Preparations/standards ; United States ; *United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heldin, C H -- Wasteson, A -- Fryklund, L -- Westermark, B -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1122-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6973821" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Growth Substances/*pharmacology ; Humans ; Neuroglia ; Peptides/*pharmacology ; Somatomedins/*pharmacology ; Structure-Activity Relationship
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    Peripherally administered reduced pterins do enter the brain (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-22
    Description: The content of tetrahydrobiopterin in rat brain was doubled by peripherally administered tetrahydrobiopterin, with the natural 1 diastereoisomer more effective than the unnatural d configuration. The model pteridine, 6-methyltetrahydropterin was ten times more efficient than tetrahydrobiopterin in crossing the blood-brain barrier, and striatal concentrations of 6-methyltetrahydropterin remained elevated for 2 hours, declining with a half-life of 3 hours. While no evidence for a specific uptake mechanism for concentrating 6-methyltetrahydropterin in cells containing tetrahydrobiopterin was detected, the pterin was found in ts presumed site of action, the nerve terminal. Replacement therapy with reduced pterins may therefore be effective in the treatment of the neurological disorders associated with the variant forms of hyperphenylalaninemia that result from defects in the biosynthesis or metabolism of tetrahydrobiopterin within the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kapatos, G -- Kaufman, S -- New York, N.Y. -- Science. 1981 May 22;212(4497):955-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233193" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biopterin/analogs & derivatives/*metabolism ; Blood-Brain Barrier ; Brain/*metabolism ; Male ; Pteridines/*metabolism ; Pterins/*metabolism ; Rats ; Stereoisomerism ; Structure-Activity Relationship
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    Clinical trial of psychotherapies is under way (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):432-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209541" target="_blank"〉PubMed〈/a〉
    Keywords: Cognition ; Depression/*therapy ; Humans ; Interpersonal Relations ; National Institutes of Health (U.S.) ; *Psychotherapy/methods ; Research Support as Topic ; United States
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  • 70
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    Cousins' account of self-cure rapped (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7029711" target="_blank"〉PubMed〈/a〉
    Keywords: Ascorbic Acid/therapeutic use ; *Famous Persons ; History, 20th Century ; *Holistic Health/history ; Humans ; Male ; Spondylitis, Ankylosing/*therapy ; United States
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    Police seize primates at NIH-funded lab (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792707" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Haplorhini ; National Institutes of Health (U.S.) ; Research/standards ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 72
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    The Hmong: dying of culture shock? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshal, E -- New York, N.Y. -- Science. 1981 May 29;212(4498):1008.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233195" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Cultural Characteristics ; *Culture ; Female ; Humans ; Laos/ethnology ; Male ; Middle Aged ; *Mortality ; Refugees/*psychology ; Stress, Physiological ; United States
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  • 73
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    Risk and benefit in environmental law (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: Judicial review establishes whether the mandate of Congress is observed by an agency's rule-making mechanisms for setting environmental standards or other regulations. Central issues in risk assessment now include whether a risk is significant, what the burden of proof for significance is, how to resolve the tension between the effort to reduce hazardous exposures and the goal of efficient regulation, and precisely how and in what detail the costs of regulation must be measured. Under current regulatory statutes, there are several paradigms for balancing costs and benefits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ricci, P F -- Molton, L S -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1096-100.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302580" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; *Environment ; Environmental Pollution ; Government Agencies ; Humans ; *Legislation as Topic ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Report absolves Harvard in case of fakery (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1982 Feb 12;215(4534):874-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058339" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; Ethics ; *Fraud ; *National Institutes of Health (U.S.) ; Research ; United States ; Hopkins, New York University, and Tufts University medical schools has decided ; that Harvard Medical School officials acted reasonably in allowing John Darsee to ; perform research for six months after he confessed to fabrication of research ; data. Although the committee found justification for Harvard's slowness in ; notifying the National Institutes of Health that Darsee was working on a federal ; study, an NIH spokesman has faulted Harvard on national television for its delay ; in reporting the problem. Excerpts from the committee's report, and its ; suggestions for preventing dishonesty in scientific research, are included here.
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    AAMC speaks on coping with fraud (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):226-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089557" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Ethics ; *Fraud ; Moral Obligations ; *Research ; Societies ; United States ; Universities ; have formal mechanisms for dealing with accusations of dishonesty made against ; their scientists. The Association of American Medical Colleges has issued a ; policy statement, "The maintenance of high ethical standards in the conduct of ; research," to encourage its member schools to develop such procedures. The AAMC ; policy offers guidelines for protecting the confidentiality of the accused and ; accusers, establishing a two-tiered system of departmental and outside ; investigation, insuring fair procedures, and determining what actions should be ; taken once the allegations are proved or disproved. Policies are also suggested ; to promote high ethical standards in all research.
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    Reagan alters makeup of ethics panel (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):715-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6954644" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Bioethical Issues ; *Ethics, Medical ; Genetic Engineering ; *Social Control, Formal ; Terminal Care ; United States ; President's Commission for the Study of Ethical Problems in Medicine and ; Biomedical and Behavioral Research. Although the Reagan appointees tend to have ; strong Republican Party ties, their opinions diverge on bioethical issues such as ; abortion. The President's Commission, currently scheduled for termination at the ; end of 1982, is involved in writing reports on sustaining the lives of the ; terminally ill, genetic screening, informed consent, genetic engineering, and ; access to health care.
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    Odor quality: semantically generated multidimensional profiles are stable (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-19
    Description: Odors of ten compounds were characterized by approximately 150 subjects who used a list of 146 descriptors. Duplicate profiles correlated highly (P less than .001) and consistently higher than profiles of different odors. Profiles also agreed with those obtained previously. Thus, profiles based on combined responses of many subjects are stable constructs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dravnieks, A -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):799-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134974" target="_blank"〉PubMed〈/a〉
    Keywords: *Alcohols ; Anisoles ; Hexanols ; Humans ; *Odors ; Pyridines ; *Smell ; Structure-Activity Relationship
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    Grant funding (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Englander, S W -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):984.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112115" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The National Cancer Chemotherapy Program (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: The National Cancer Chemotherapy Program was initiated in 1955. It is administered and integrated by the Division of Cancer Treatment at the National Cancer Institute. The program involves the discovery and development of potential new antitumor agents; their screening in preclinical experimental systems for antitumor effect, and, if active, for toxicology; and, for selected agents, preliminary, and more definitive clinical trials. While serendipity and empiricism played a substantial role in the early years of the program, the program has increasingly emphasized and been influenced by advances in tumor biology, drug development, clinical pharmacology, and the science of clinical trials. There has been effective interaction between investigator-initiated research on the one hand and developmental research at preclinical and clinical levels on the other. Over 30 chemotherapeutic agents with substantial clinical antitumor activity have been discovered, and their proper use, often in combination and often integrated with surgery or radiotherapy, has resulted in significant progress in the effective treatment of many forms of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frei, E 3rd -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):600-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046055" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/adverse effects/*therapeutic use ; Antineoplastic Agents, Phytogenic/therapeutic use ; Clinical Trials as Topic ; Drug Evaluation ; Drug Evaluation, Preclinical ; Forecasting ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*drug therapy/mortality ; Research ; United States
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    Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: Morphine, methadone, meperidine, fentanyl, and clonidine rapidly depressed transmission through sympathetic preganglionic neurons in cats with the spinal cord transected. Naloxone promptly antagonized this effect of the opiates but not that of clonidine which was reversed by alpha 2-adrenergic receptor antagonists. The independent depression of preganglionic neurons by clonidine may contribute to the ability of this drug to depress the symptoms of opiate withdrawal that are characterized by sympathetic hyperactivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Franz, D N -- Hare, D B -- McCloskey, K L -- GM-07579/GM/NIGMS NIH HHS/ -- HL-24085/HL/NHLBI NIH HHS/ -- RR-05428/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1643-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Clonidine/*pharmacology/therapeutic use ; Evoked Potentials/drug effects ; Humans ; Narcotics/pharmacology ; Receptors, Drug/drug effects ; Reflex/drug effects ; Spinal Cord/cytology ; Structure-Activity Relationship ; Substance Withdrawal Syndrome/*drug therapy ; Sympathetic Nervous System/*drug effects ; Synaptic Transmission/*drug effects
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    Federal information services (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, I Y -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):107.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806901" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Government Agencies ; *Information Services ; *National Library of Medicine (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    NIH 3T3 cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Littlefield, J W -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; *Cell Line ; Mice ; Mice, Inbred BALB C ; National Institutes of Health (U.S.) ; United States
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    TV report affirms violence-aggression link (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079761" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Child ; Humans ; *Television ; United States ; *Violence
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  • 84
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    EPA's high-risk carcinogen policy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):975-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6897126" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; *Government Agencies ; Risk ; United States ; *United States Environmental Protection Agency
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  • 85
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    A turnabout on EPA lead rules (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):711.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100912" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Environmental Exposure ; *Government Agencies ; Humans ; *Lead ; United States ; *United States Environmental Protection Agency
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  • 86
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    USDA research under fire (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089537" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; *Government Agencies ; Research/*standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    NRC must weigh psychic costs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1203-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079754" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Agencies ; Humans ; Jurisprudence ; *Radiation Injuries ; Stress, Psychological ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    Yellow rain: filling in the gaps (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):31-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089535" target="_blank"〉PubMed〈/a〉
    Keywords: Asia, Southeastern ; *Chemical Warfare ; Humans ; *Mycotoxins ; Ussr ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    New disease baffles medical community (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):618-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089584" target="_blank"〉PubMed〈/a〉
    Keywords: Haiti/ethnology ; Homosexuality ; Humans ; Immunologic Deficiency Syndromes/*epidemiology/etiology ; Male ; Sarcoma, Kaposi/complications ; Substance-Related Disorders ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    "Cancer is not inevitable" (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089539" target="_blank"〉PubMed〈/a〉
    Keywords: *Diet ; Humans ; Neoplasms/etiology/*prevention & control ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Marijuana "justifies serious concern" (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1488-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6977847" target="_blank"〉PubMed〈/a〉
    Keywords: Cannabinoids/therapeutic use ; *Cannabis ; Humans ; Marijuana Abuse/epidemiology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Environmental uses of the NIH-EPA chemical information system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-22
    Description: A publicly accessible computer system for chemical information has been developed jointly by a number of agencies of the U.S. government. The system contains spectroscopic, crystallographic, toxicological, and regulatory data for more than 200,000 chemicals. The entire data base may be searched for a particular chemical structure or substructure, whose properties may then be retrieved. Alternatively, searching with numeric properties data is possible, permitting the identification of chemicals. Access is by local telephone call, and the system is used on a fee-for-service basis by organizations in over 20 countries. An important application of the system is to problems of chemical pollution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milne, G W -- Fisk, C L -- Heller, S R -- Potenzone, R Jr -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):371-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058322" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; *Chemistry ; Computers ; Environmental Pollutants/analysis ; Information Systems/*organization & administration ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Martin Cline loses appeal on NIH grant (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):37.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123214" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant ; Ethics, Medical ; Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; by the National Institutes of Health to withhold funding from Martin J. Cline, a ; researcher at the University of California at Los Angeles who in July 1980 ; violated regulations governing recombinant DNA research and human ; experimentation. Cline may continue to apply for federal grants, but under ; special restrictions that will be in effect until May 1984.
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  • 94
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    Stanford patent delayed (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):712-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100913" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; *Patents as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    DNA conformation, dynamics, and interactions in solution (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: The conformation and dynamics of the d(CGCGAATTCGCG) duplex, its analogs containing mismatched base pairs and helix interruptions, and its complexes with actinomycin and Netropsin, bound separately and simultaneously, have been investigated by nuclear magnetic resonance spectroscopy in aqueous solution. Structural information has been deduced from chemical shift and nuclear Overhauser effect parameters, while the kinetics have been probed from line width and saturation recovery experiments on proton and phosphorus markers at the individual base pair level. These studies lead to an improved understanding of the role of nucleic acid sequence on the structure, flexibility, and conformational interconversions in the duplex state. The nuclear magnetic resonance measurements readily identify helix modification and antibiotic binding sites on the nucleic acid and estimate the extent to which the observed conformational and dynamic perturbations are transmitted to adjacent base pair regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patel, D J -- Pardi, A -- Itakura, K -- New York, N.Y. -- Science. 1982 May 7;216(4546):581-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280281" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Dna ; Dactinomycin ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Motion ; Netropsin ; *Nucleic Acid Conformation ; Oligodeoxyribonucleotides ; Protons ; Structure-Activity Relationship ; Temperature
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  • 96
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    (+)-Amphetamine binding to rat hypothalamus: relation to anorexic potency for phenylethylamines (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Saturable and stereospecific binding sites for (+)-[3H]amphetamine were demonstrated in membrane preparations from rat brain. The density of these binding sites varies among brain regions and is highest in the hypothalamus and brainstem. Specific (+)-[3H]amphetamine binding in hypothalamus is largely confined to synaptosomal membranes, rapidly reversible, and sensitive to both heat and proteolytic enzymes. Scatchard analysis of the equilibrium binding data revealed two distinct sites with apparent affinity constants of 93 and 300 nanomoles per liter, respectively. The effects of various psychotropic drugs as well as a number of putative neurotransmitters and related agonists and antagonists in displacing specific (+)-[3H]amphetamine binding demonstrate that these binding sites are not associated with any previously described neurotransmitter or drug receptors, but are specific for amphetamine and related phenylethylamine derivatives. Furthermore, the relative affinities of a series of phenylethylamine derivatives for (+)-[3H]amphetamine binding sites in hypothalamic membranes is highly correlated to their potencies as anorexic agents. These results suggest the presence of specific receptor sites in hypothalamus that mediate the anorexic activity of amphetamine and related drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, S M -- Hulihan-Giblin, B -- Skolnick, P -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):487-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123250" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anorexia/physiopathology ; Appetite Depressants/*pharmacology ; Cell Membrane/metabolism ; Dextroamphetamine/*metabolism ; Hypothalamus/drug effects/*metabolism/physiology ; Male ; Phenethylamines/metabolism ; Rats ; Receptors, Drug/*metabolism ; Structure-Activity Relationship
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    A new arthritis institute nears approval (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):610-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896390" target="_blank"〉PubMed〈/a〉
    Keywords: *Arthritis ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.)/*organization & administration ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Use of "Super-plus" tampons discouraged (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281894" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Centers for Disease Control and Prevention (U.S.) ; Female ; Humans ; *Menstruation ; Shock, Septic/*etiology ; Tampons, Surgical/*adverse effects ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    NIH developing policy on misconduct (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 May 14;216(4547):711-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079729" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Federal Government ; Government Regulation ; *National Institutes of Health (U.S.) ; Research/*standards ; United States ; when a university should have to inform the government that one of its ; federally-funded researchers is suspected of wrongdoing. A committee is expected ; to submit a draft set of recommendations shortly. The problems that universities ; face in this area are illustrated by a recent case being investigated by NIH, in ; which a UCLA researcher's calculations linking a rare motor disorder with an ; enzyme deficiency have been shown to be incorrect, though not necessarily ; willfully misrepresented.
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  • 100
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    Crisis in NIH funding (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesell, E S -- Mandel, H G -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063837" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; Research Support as Topic/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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