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  • Articles  (61)
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  • American Association for the Advancement of Science (AAAS)  (61)
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  • Articles  (61)
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  • American Association for the Advancement of Science (AAAS)  (61)
  • American Geophysical Union
  • American Meteorological Society
  • American Physical Society (APS)
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  • 2010-2014  (13)
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  • 1
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    2013 Runners-Up. Human cloning at last (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2013 Dec 20;342(6165):1436. doi: 10.1126/science.342.6165.1436-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Separation ; Cloning, Organism/*methods ; Female ; Humans ; *Induced Pluripotent Stem Cells ; Nuclear Transfer Techniques ; Pregnancy ; *Research Embryo Creation ; Surrogate Mothers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that combined exposure to prenatal immune challenge and peripubertal stress induces synergistic pathological effects on adult behavioral functions and neurochemistry. We further demonstrate that the prenatal insult markedly increases the vulnerability of the pubescent offspring to brain immune changes in response to stress. Our findings reveal interactions between two adverse environmental factors that have individually been associated with neuropsychiatric disease and support theories that mental illnesses with delayed onsets involve multiple environmental hits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giovanoli, Sandra -- Engler, Harald -- Engler, Andrea -- Richetto, Juliet -- Voget, Mareike -- Willi, Roman -- Winter, Christine -- Riva, Marco A -- Mortensen, Preben B -- Feldon, Joram -- Schedlowski, Manfred -- Meyer, Urs -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1095-9. doi: 10.1126/science.1228261.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/immunology ; Disease Models, Animal ; Female ; Humans ; Mental Disorders/*immunology ; Mice ; Mice, Inbred C57BL ; Poly I-C/immunology/pharmacology ; Pregnancy ; Prenatal Exposure Delayed Effects/*immunology/virology ; Puberty/*immunology ; Stress, Physiological/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Response to comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: Lazic criticizes the statistical analyses used to support the conclusions in our mouse model. His theory-biased criticism is disproportionate in view of the robustness of our findings (even if different statistical methods are applied) and falls short in explaining the postpubertal onset of effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giovanoli, Sandra -- Meyer, Urs -- New York, N.Y. -- Science. 2013 May 17;340(6134):811. doi: 10.1126/science.1238060.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, Schwerzenbach, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23687030" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Humans ; Mental Disorders/*immunology ; Pregnancy ; Prenatal Exposure Delayed Effects/*immunology ; Puberty/*immunology ; Stress, Physiological/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Virology. Our viral inheritance (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, Robin A -- Stoye, Jonathan P -- MC_U117512710/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2013 May 17;340(6134):820-1. doi: 10.1126/science.1235148.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK. rweiss@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23687035" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Viral/genetics ; Endogenous Retroviruses/*genetics ; Female ; Genome, Human/*genetics ; Humans ; Placenta/virology ; Pregnancy ; Promoter Regions, Genetic ; Proviruses/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Response to comment on "The placental mammal ancestor and the post-K-Pg radiation of placentals" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-10
    Description: Tree-building with diverse data maximizes explanatory power. Application of molecular clock models to ancient speciation events risks a bias against detection of fast radiations subsequent to the Cretaceous-Paleogene (K-Pg) event. Contrary to Springer et al., post-K-Pg placental diversification does not require "virus-like" substitution rates. Even constraining clade ages to their model, the explosive model best explains placental evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Leary, Maureen A -- Bloch, Jonathan I -- Flynn, John J -- Gaudin, Timothy J -- Giallombardo, Andres -- Giannini, Norberto P -- Goldberg, Suzann L -- Kraatz, Brian P -- Luo, Zhe-Xi -- Meng, Jin -- Ni, Xijun -- Novacek, Michael J -- Perini, Fernando A -- Randall, Zachary -- Rougier, Guillermo W -- Sargis, Eric J -- Silcox, Mary T -- Simmons, Nancy B -- Spaulding, Michelle -- Velazco, Paul M -- Weksler, Marcelo -- Wible, John R -- Cirranello, Andrea L -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):613. doi: 10.1126/science.1238162.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomical Sciences, HSC T-8 (040), Stony Brook University, Stony Brook, NY 11794-8081, USA. maureen.oleary@stonybrook.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929968" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Female ; *Fossils ; *Mammals ; *Phylogeny ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Technical comment on "The placental mammal ancestor and the post-K-Pg radiation of placentals" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-10
    Description: O'Leary et al. (Research Article, 8 February 2013, p. 662) examined mammalian relationships and divergence times and concluded that a single placental ancestor crossed the Cretaceous-Paleogene (K-Pg) boundary. This conclusion relies on phylogenetic analyses that fail to discriminate between homology and homoplasy and further implies virus-like rates of nucleotide substitution in early Paleocene placentals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Springer, Mark S -- Meredith, Robert W -- Teeling, Emma C -- Murphy, William J -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):613. doi: 10.1126/science.1238025.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Riverside, CA 92521, USA. mark.springer@ucr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929967" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Female ; *Fossils ; *Mammals ; *Phylogeny ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Evolution. Fossils versus clocks (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoder, Anne D -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):656-8. doi: 10.1126/science.1233999.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Duke University, Durham, NC 27708, USA. anne.yoder@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23393254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Female ; *Fossils ; *Mammals ; *Phylogeny ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: Giovanoli et al. (Reports, 1 March 2013, p. 1095) applied an immune challenge to pregnant females, and therefore to all offspring, and subsequently applied stress to offspring on a per cage basis. The data, however, were analyzed as a completely randomized design, which is inappropriate given these restrictions on randomization. This will increase both false positives and false negatives.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazic, Stanley E -- New York, N.Y. -- Science. 2013 May 17;340(6134):811. doi: 10.1126/science.1237793.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland. stan.lazic@cantab.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23687029" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Humans ; Mental Disorders/*immunology ; Pregnancy ; Prenatal Exposure Delayed Effects/*immunology ; Puberty/*immunology ; Stress, Physiological/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Alarm over autism test (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2013 Sep 13;341(6151):1164-7. doi: 10.1126/science.341.6151.1164.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24030995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autistic Disorder/*diagnosis/*immunology ; Brain/embryology/*immunology ; California ; Child, Preschool ; Female ; Fetal Proteins/*immunology ; Humans ; *Immunologic Tests ; Maternal-Fetal Exchange/immunology ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Intellectual property. California moves shake up prenatal gene testing market (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2013 Nov 8;342(6159):680. doi: 10.1126/science.342.6159.680.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24202151" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/blood ; Down Syndrome/*diagnosis ; Female ; Genetic Testing/*legislation & jurisprudence ; Humans ; Intellectual Property ; Male ; Patents as Topic/*legislation & jurisprudence ; Pregnancy ; Prenatal Diagnosis/*methods ; San Francisco
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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