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  • 101
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 627-645 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Based on the principle of minimum power, a mathematical model of the functional state of the oxygen transport system is presented. The optimization model minimizes the power expenditure of the heart, bone marrow, lung and other tissues. The model is used to determine the functional parameters of the oxygen transport system in man under both normal and varying barometric pressures. Theoretical results are compared with experimental data.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 102
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 601-625 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A quantitative model of ion binding and molecular interactions in the lipid bilayer membrane is proposed and found to be useful in examining the factors underlying such membrane characteristics as shape, sidedness, stability and vesicle size at various cation concentrations. The lipid membrane behaves as a bilayer couple whose preferential radius of curvature depends on the expansion or contraction of one monolayer relative to the other. It is proposed that molecular packing may be altered by electrostatic repulsion of adjacent like-charged phospholipid headgroups, or by bringing two headgroups closer together by divalent cation crossbridging. The surface concentrations of each type of cation-phospholipid complex can be described by simple binding equilibria and the Gouy-Chapman-Stern formulation for the surface potential in a diffuse double layer. The asymmetric distribution of acidic phospholipids in most biological membranes can account for the differential effects of identical ionic environments on either side of the bilayer. The fraction of vesicle material which tends to have a right-side-out orientation may be approximated by a normal distribution about the mean curvature. The theory generates vesicle sidedness distributions that, when fitted to experimental results from human erythrocyte membranes, provide an alternative method of estimating intrinsic cationphospholipid dissociation constants and other molecular parameters of the bilayer. The results also corroborate earlier suggestions that the Gouy-Chapman theory tends to overestimate free counter-ion concentrations at the surface under large surface potentials.
    Materialart: Digitale Medien
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  • 103
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 681-689 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The “yellow strips” on the cuticle of the Oriental Hornet (Vespa orientalis, Hymenoptera, Vespinae), present photoelectric properties. A mathematical model for the relative changes in resistance as a photoconductive process conforms to the general model for a semiconductor with traps.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 104
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 701-718 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Damped nonlinear oscillations in biological and biochemical systems are investigated by the extended Krylov-Bogoliubov-Mitropolskii (KBM) method. A review on the extension made by Popov to the KBM method is given and also further improvements are presented. Applications are made to models of oscillating chemical reactions (Lefever and Nicolis, 1971), FitzHugh (1961) equations, and population dynamics (Gatto and Rinaldi, 1977). Comparison to damped oscillating physical and engineering systems is made.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 105
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 719-728 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The conditions that will allow the lumping together of several age classes in the Leslie model are investigated. We show that if the lumping is to be valid for all population distributions, then the parameters of the model must be periodic. Lumping is valid when the population is in equilibrium, but equilibrium should be tested before the model is lumped.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 106
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 647-679 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Catastrophe theory is a mathematical theory which, allied with a new and controversial methodology, has claimed wide application, particularly in the biological and the social sciences. These claims have recently been heatedly opposed. This article describes the debate and assesses the merits of the different arguments advanced.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 107
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 765-795 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Estimates of capillary tracer permeability calculated using multiple indicator data depend upon the particular model adopted to describe blood tissue exchange. The model proposed by Crone (1963) is appropriate when some of the injected tracer diffuses into the tissue but does not return appreciably to the bloodstream before data collection is terminated. Under these conditions extraction of tracer by the tissue depends on a single dimensionless parameter, αcap, defined as the ratio of capillary permeability surface area to water flow. The effects of finite red cell tracer permeability on the Crone model estimate of capillary permeability are examined in the present study. The results indicate that even when back diffusion from the extravascular space is negligible, significant errors in the Crone model estimate can be expected when capillary permeability is relatively high and the ratio of red cell to capillary permeability is less than unity. However, when an aliquot of blood is equilibrated with tracer prior to injection and the dimensionless capillary permeability is relatively low (i.e. αcap ≦ 0.25 for a haematocrit≦50%), the whole blood Crone model estimate of αcap will be within 10% of the actual value, irrespective of red cell permeability. Red cell-plasma exchange for commonly used tracer-organ combinations should not significantly affect Crone estimates of capillary permeability under normal physiological conditions, but may be important in low flow situations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 108
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 807-828 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Assuming truncated ellipsoidal geometry for the right and left ventricles, a model is developed for the myocardium enabling biventricular mechanical behavior to be studied. Employing pressure-volume data taken from normal dog hearts and from hearts in which the pulmonary artery has been banded over periods of 2–40 weeks, it is shown that: (a) right ventricular wall stresses are higher than left ventricular stresses; (b) right ventricular wall stress increases initially to a maximum after 3–4 weeks followed by a decline to normal and even subnormal levels, attaining a minimum value at 32–33 weeks; (c) left ventricular stresses behave in a similar manner, attaining their maximum and minimum levels after 7–8 weeks and 32–33 weeks respectively. These results suggest that surgical or medical therapy in patients with hypertrophied ventricles might be more appropriate during the period of wall stress reduction.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 109
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 837-845 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In this paper we describe a mathematical model of the oscillations of the diaphragm which limits the vitreous body from the anterior segment of the human eye after the lens has been removed in a cataract operation. We study the motion of this diaphragm driven by movements of the eye. Firstly, a mathematical statement of the problem is given and then we solve the problem exactly for a given class of eye movements. From the analysis we deduce that significant oscillations of the membrane are driven by saccades and that it is the angular acceleration of the eye which causes these types of oscillations. A numerical example is given.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 110
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 871-887 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The Lotka-Volterra system of prey-predator equations is considered with a special type of continuous time delay. In the case of equal diffusion coefficients Hopf’s bifurcation technique is used to show the existence of travelling wave train solutions for the prey-predator system.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 111
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 861-870 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 112
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 847-859 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new model of the upper tracheobronchial tree is proposed to account for the three-dimensional nature of the airway system. In addition to the tube length, the tube diameter, and the branching angle, the model includes information on the orientation angle of each tube relative to its parent tube. The orientation angle, defined as the angle between two successive bifurcations, is useful for calculating the gravitational inclination of each tube. The information on orientation angle is further used to construct a binary coding system for identifying individual tubes in the airway tree. The proposed model is asymmetrical, but the same principles can be readily used to construct a symmetrical one.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 113
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 889-897 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In any control system for which the number of independent controls is smaller than the number of degrees of freedom to be controlled, our choice of control in any state is restricted to a submanifold of smaller dimension than the tangent space. This simple fact has a number of important consequences for questions of biological import; we consider its implications for adaptation, for senescent phenomena and for the determination of tertiary structures of polypeptides through control of certain average properties. We also formulate the Pontryagin Maximum Principle of Optimal control theory in such a way as to inquire whether specific biodynamic systems can be regarded as optimal with respect to rate of accumulation of particular quantities of the system. We find that if this is possible, the quantity in question must play the role of a clock.
    Materialart: Digitale Medien
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  • 114
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 899-900 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 115
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. iii 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 116
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 1-11 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A stochastic model for the population regulated by logistic growth and spreading in a given region of two-or three-dimensional space has been introduced. For many-species population the interactions among the species have also been icorporated in this model. From the random variables that describe stochastic processes of a Wiener type the space-dependent random population densities have been formed and shown to satisfy the Langevin equations. The Fokker-Planck equation corresponding to these Langevin equations has been approximately solved for the transition probability of the population spreading and it has been found that such approximate expressions of the transition probability depend on the solutions of the deterministic equations of the diffusion model with logistic growth and interactions. Also, the stationary or equilibrium solutions of the Fokker-Planck equation together with the special discussion on the pattern of single-species population spreading have been made.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 117
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 13-50 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The notion of an evolutive hierarchical system proposed in this paper is a mathematical model for systems, like organisms, with more or less complex objects. This model, based on category theory, retains the following characteristics of natural systems: they have an internal organization consisting of components with interrelations; they maintain their organization in time though their components are changing; their components are divided into several levels corresponding to the increasing complexity of their own organization, and the system may be studied at any of these levels (e.g. molecular, cellular...). The state of the system at a given instant is modeled by a category whose objects are its components, the state transition by a functor, a complex object by the (direct) limit of a pattern of linked objects (which describes its internal organization). The properties of limits in a category make it possible to ‘measure’ the emergence of properties for a complex object with respect to its components, and to reduce the study of a hierarchical system to that of its components of the lowest degree and their links. Categorical constructions describe the formation of a hierarchical evolutive system stepwise, by means of the operations: absorption of external objects, destruction of some components, formation of new complex objects.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 118
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 93-123 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract An algorithmic formulation is presented for the inference procedure concerning lineage models. The problem is to find lineage rules from observed sequences of tree structures under the assumption that no interactions take place in the course of development and that sufficiently frequent observations are available at equal time intervals. The underlying structural pattern is taken to be a OL system, and the goal is to find propagating and deterministic OL schemes with minimal properties satifsying certain biological reliance criteria. Upper bounds have been found for the complexity of the inference algorithms.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 119
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 125-131 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A statistical theory of non-equilibrium fluctuation in Volterra-Lotka systems has been presented on the basis of the technique of statistical linearization of non-linear coupled stochastic differential equations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 120
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 135-152 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Under certain basic assumptions the branching pattern of dendrites can be modeled as a Galton-Watson process in varying environment. Using results from graph theory we compute the probability distributions, expectations and variances for biologically significant variables such as the number of (intermediate and terminal) branches, the maximum number of orders, etc., together with the limit behavior of these quantities. Furthermore, the probability measure induced by the Galton-Watson process on the set of all trees is calculated. The measure assigns to any set of branching patterns the probability that it is realized by a certain process, which is completely described through the bifurcation probabilities.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 121
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 187-216 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Theoretical models for DNA repair mechanisms are constructed. Reliability studies considering the living cell as a repairable system are done. The DNA repair process is discussed along with applications and comparison with available experimental data.
    Materialart: Digitale Medien
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  • 122
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 153-169 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A mathematical model has been developed to simulatein vivo transmural accumulation of an intravenously injected tracer in the aortic wall of experimental animals. Parameters have been included to represent the following processes that affect tracer distribution: permeation of the blood-tissue interface, diffusion through the layers of the artery wall,convective solute drag through the same, and degradation. Of particular interest for thein vivo situation situation is the inclusion of boundary conditions that account for the variation in the plasma concentration of injected tracer as a function of time. Two analytical solutions are presented. The first describes a system in which two boundaries must be delineated; it pertains if the tracer is allowed to circulate until it enters the avascular media of the artery wall both across its luminal boundary and from the capillaries in its outer layer. The second applies to shorter duration experiments in which entry across only the luminal boundary is considered. A limiting case of the solution for short circulation times is presented, compared with a previously published solution, and examined for its potential utility in parameter estimation. Because of its treatment of time-dependent boundary conditions, the model has unique application toin vivo experiments related to macromolecular transport in atherosclerosis that may otherwise elude proper interpretation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 123
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 49 (1987), S. 233-252 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Several current reaction-diffusion mechanisms have been proposed as models for morphogenesis in the Turing (1952,Phil. Trans. R. Soc. Lond. B 237, 37–72) sense. We introduce and exploit a quantity, we have termed heterogeneity, which allows us to elaborate the differences between the various models with regard to spatial pattern formation. It is shown that this quantity provides a concise view for the comparison of theoretical models with experimental observations. Two model mechanisms are treated explicitly both for linear and for biased diffusion.
    Materialart: Digitale Medien
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  • 124
    Digitale Medien
    Digitale Medien
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    Bulletin of mathematical biology 49 (1987), S. 351-361 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The optimum number of total capillaries in the whole human body was estimated from the analysis of the efficiency for oxygen (O2) transport in the vascular-tissue system. We used a tissue model composed of uniform spheres in which O2 diffuses from the capillary located at the centre of each sphere towards the surrounding tissue consuming O2 at a constant rate. The tissue mass supplied by a single capillary was estimated as the area of positive O2 concentration under a given condition of capillary flow and O2 consumption rate. Total tissue mass was determined as the function of the capillary numbern and the total blood flow. On the other hand, the energy cost required to maintain the vascular system withn terminals was assessed by using the minimum volume model (Kamiya and Togawa,Bull. math. Biophys. 34, 431–438, 1972). The efficiency of the entire vascular-tissue system was evaluated by calculating the ratio of total tissue mass/cost function. The result of the calculation using physiological data of cardiac output and O2 consumption for an average human adult during a heavy exercise revealed the maximum efficiency occurring at the capillary number 3.7×1010 which coincided well with its normal range of physiological estimates (3.2×1010–4.2×1010). We concluded that the entire vascular-tissue system is constructed so as to attain the highest efficiency in O2 transport at its maximum activity.
    Materialart: Digitale Medien
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  • 125
    Digitale Medien
    Digitale Medien
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    Bulletin of mathematical biology 49 (1987), S. 379-394 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A kinetic model involving synthesis of proinsulin in the rough endoplasmic reticulum, maturation through the Golgi apparatus and granules, with conversion to insulin, is proposed to account for data on the amount of insulin and of proinsulin both secreted during various time intervals and remaining in islets. Introducing three compartments for granules makes it possible to account for the measurement of both hot (pulse labeled with tritiated leucine) and cold proinsulin and insulin over a period of 21/2 hr under constant glucose. Data from islets from animals pretreated with tolbutamide are also presented and modeled. The model is then expanded so that it can be successfully applied to available data on the effects of a period of glucose deprivation on secretion of both hot and cold hormone. Parameters have essentially the same values, where they overlap, as were obtained (Landahl and Grodsky, 1982Bull. math. Biol. 44, 399–410) from insulin secretion by perfused rat pancreas stimulated by a variety of temporal patterns of glucose concentration.
    Materialart: Digitale Medien
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  • 126
    Digitale Medien
    Digitale Medien
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    Bulletin of mathematical biology 49 (1987), S. 413-429 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Two models of binary tree growth are examined in terms of the Strahler order branching ratio (Rb) and the types of vertex produced during growth, and their inter-relationship. The sequential growth model is that described by Van Pelt and Verwer (1985,Bull. math. Biol. 47, 323–336) in which random growth occurs according to attributed probabilities on terminal or internal segments, one branch at a time. This model generates values ofRb≥3. The synchronous growth model is new and permits more than one segment to branch at a time, again randomly with attributed probabilities. This model generates values ofRb≥2 and in particular, when only terminal branching is permitted, gives 2≤Rb〈3. Such a model might explain the branching in the human bronchial tree, in which 2.5≤Rb≤2.8. Our synchronous model is an alternative to the centrifugal-order-dependent sequential model of Van Pelt and Verwer.
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  • 127
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    Bulletin of mathematical biology 49 (1987), S. 449-460 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract From an energy budget of a deciduous plant leaf in moderate conditions, entropy fluxes into or out of the leaf due to solar radiation, infrared radiation, evaporation of water and heat conduction are calculated. Net entropy flow into the leaf is negative. On the assumption that the entropy in the leaf is in a steady state, the entropy production in the typical deciduous leaf in moderate conditions [the solar energy absorbed by both sides of the leaf isE solar=0.0602 (J cm−2 s−1)] becomesS prod=1.8×10−4 (J cm−2 s−1 K−1). The positiveness of the entropy production shows that the Second Law of Thermodynamics certainly holds in the plant leaf. Entropy productions in other conditions are also calculated. The entropy production in the leafS prod becomes a linear function of the solar energy absorbed by the leafE solar:S prod≈-(29.5E solar)×10−4. A theorem is presented: the entropy production in plant leaves oscillates during the period of one day, paralleling the daily solar energy absorbed by leaves.
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  • 128
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    Digitale Medien
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    Bulletin of mathematical biology 49 (1987), S. 461-467 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Molecular biologists strive to infer evolutionary relationships from quantitative macromolecular comparisons obtained by immunological, DNA hybridization, electrophoretic or amino acid sequencing techniques. The problem is to find unrooted phylogenies that best approximate a given dissimilarity matrix according to a goodness-of-fit measure, for example the least-squares-fit criterion or Farris'sf statistic. Computational costs of known algorithms guaranteeing optimal solutions to these problems increase exponentially with problem size; practical computational considerations limit the algorithms to analyzing small problems. It is established here that problems of phylogenetic inference based on the least-squares-fit criterion and thef statistic are NP-complete and thus are so difficult computationally that efficient optimal algorithms are unlikely to exist for them.
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  • 129
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    Bulletin of mathematical biology 38 (1976), S. 95-96 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
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  • 130
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    Bulletin of mathematical biology 38 (1976), S. 119-133 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A method, based on symmetry, is suggested for determining the information content of systems. A comparison has been made between the information for symmetry, topology, and chemical composition. The new information measure increases when the asymmetry of the molecules and the number of atoms in the latter increases. It can distinguish between different molecular conformations, and give a linear correlation with the absolute entropy for homologous series of chemical compounds.
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  • 131
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    Bulletin of mathematical biology 38 (1976), S. 135-159 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The micromorphic theory of Eringen is applied to study the tube flow of blood. The blood is considered to be a deformable suspension, with constitutive relations of the form of those of simple microfluids. By means of energy consideration, a relation is established between the local concentration parameter and the measure of rotationality involving both macro-and micromotions. The tube flow problem is then solved with some analyses on viscosity coefficients and boundary conditions. The results obtained indicate an integrated explanation of various important physical phenomena associated with blood flow, such as the tube size dependence of the apparent viscosity and the non-uniform concentration distribution over a tube cross section.
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  • 132
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    Bulletin of mathematical biology 38 (1976), S. 193-197 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract By observing that the n-tuple of rate functionsQ(c) is orthogonal to the c-space gradients of each of the (n - 1) constants of the motion Φ v (c), a generic canonical expression for the rate functions is given in terms of the exterior product of the gradients of the (n - 1) Φ v 's. For models withQ so prescribed from the outset, an analytical general solution is obtainable directly for the system of autonomous ordinary differential equations dc/dt =Q(c). Thus, the generic canonical expression for the rate functions can be utilized to construct analytically solvable models for interacting biological species, as ilIus~rated by examples here.
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  • 133
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    Bulletin of mathematical biology 38 (1976), S. 39-57 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A model for the extraocular plant of the human visual eye tracking mechanisms is discussed. Its sensitivity to variation of controller signal nervous activity is studied in order to determine the type of activity that yields realistic simulations characteristic of typical saccadic eye movements.
    Materialart: Digitale Medien
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  • 134
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    Bulletin of mathematical biology 38 (1976), S. 359-368 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Mathematical models of predator-prey systems in which the prey species has a three-stage life cycle are studied. Certain stages of the prey life history are allowed to use younger stages as food. It is shown that sufficiently restricted cannibalism can result in an increase in the numbers of adult prey on a sustained basis when cannibalism decreases the vulnerability of a stage subject to predation or increases overall productivity.
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  • 135
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    Bulletin of mathematical biology 38 (1976), S. 369-386 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A general analysis is presented for the thermal behavior of a biological tissue. Energy transport by the circulatory system is assumed to be represented by a modified Fick's law. General boundary conditions are assumed for the two-dimensional model and solutions are obtained for rectangular, cylindrical, and spherical geometries. The effects of blood perfusion rate, metabolic rate, arterial temperature and heat exchange with the environment are considered. Results indicate a region of almost constant temperature in the deeper layers of the tissue and reaffirm the important role which blood flow plays in maintaining homeostasis.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 136
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    Bulletin of mathematical biology 38 (1976), S. 351-358 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The oscillatory aspect in a system having two steady states is studied theoretically using a model of excitable nerve membrane. The condition for the occurrence of oscillatory instability is discussed on the basis of the kinetic picture of nerve excitation in consideration of the non-Markoffian effect caused by ion transport in the system. Small oscillations around a steady state as well as a giant fluctuation between two states are obtained. Results are compared with experiments carried out with squid giant axons perfused intracellularly.
    Materialart: Digitale Medien
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  • 137
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    Bulletin of mathematical biology 38 (1976), S. 415-423 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract An expression for the variance in birth volumes during balanced growth of a cell population is derived. The requirement of this expression being positive and finite allows a discussion of some of the requirements imposed on the mechanisms of growth and division.
    Materialart: Digitale Medien
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  • 138
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    Bulletin of mathematical biology 38 (1976), S. 425-433 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The phenomenon of axonal transport of material has been well documented (Ochs, 1971; Lasek, 1970; and Grafstein, 1967). This report seeks to establish the role of diffusion—if any—in such a transport process. We report that diffusion cannot account for the observed build-up of material as reported in the literature.
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  • 139
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    Bulletin of mathematical biology 38 (1976), S. 445-452 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The question of how to fit a general cubic model of a multicomponent, interactive growth system to observed data is addressed. A multidimensional-polynomial type of regression analysis is used, with a least-squares criterion. By testing the scheme on a problem with known solution, the way in which the accuracy of the results varies with the number of datum points used is investigated in an heuristic manner.
    Materialart: Digitale Medien
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  • 140
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    Bulletin of mathematical biology 38 (1976), S. 453-458 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The describing function method is used as a guide to the behaviour of the solutions of the equations of Danziger and Elmergreen, proposed as a model of periodic catatonia. The method suggests that whenever the equilibrium point is unstable it is surrounded by a stable closed periodic orbit. This is confirmed in specific cases by computation.
    Materialart: Digitale Medien
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  • 141
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    Bulletin of mathematical biology 38 (1976), S. 497-504 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A theory of ambiguous pattern perception is formulated. This theory proposes a feature selector (field of attention) based on the time-sequential discrete property of the attention, a short-term memory for storage of the selected features, and a displayer (perception) to display the consecutively stored features. Since the selected features continuously enter, and since the features can only be stored in the short-term memory for a short period, the features which can be displayed in the displayer vary with time. When all the essential features belonging to one pattern happen to be in the displayer, the picture is perceived to be that pattern; when all the essential features belonging to another pattern happen to be in the displayer, then the picture is perceived to be the other pattern. Thus the picture appears to vary with time and alternate between two patterns. A numerical calculation is presented.
    Materialart: Digitale Medien
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  • 142
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    Bulletin of mathematical biology 38 (1976), S. 479-496 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The thermodynamics of irreversible processes is derived from the principles of dynamical field theory independently of all elements of thermostatics, in particular the assumption of local equilibrium. Field thermodynamics proceeds from the premise that all driving forces experienced by the molecules in a continuum are conservative and arise from scalar potential functions. Dynamically the temperature potentialT is no different from the pressure potentialp. A field is converted to a force upon multiplication by a scale factor. A potential is converted to potential energy by the same scale factor. To scale the field −∇p to the force per mole of molecular speciesk, the partial molar, volume $$\bar V_k $$ is the scale factor. Similarly the partial molar entropy, $$\bar S_k $$ , scales the temperature field. The transition from the scale factors (which are physical parameters) to the systemic variables, for example $$\bar S_k \to s\left( {x,y,z;t} \right)$$ , is not trivial. From the dynamics and the structure of the derived potential energy function are inducted the conjugate variables such as (p, V I) and (T, s). The meta-mechanical properties of the thermal variables (T, s) are discovered via the local First Law of Thermodynamics, which relates internal energy, thermal flux, and work, and from the local Second Law, which prescribes, the possible partitions of internal energy between kinetic, potential, and thermal energies. From the form of the potential energy come Maxwell's relationships. From the energy partition comes the equation of continuity for entropy, with its important source term. In contrast to earlier theories of irreversible thermodynamics, the dissipation function does not include the stress tensor, a constitutive parameter.
    Materialart: Digitale Medien
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  • 143
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    Bulletin of mathematical biology 38 (1976), S. 527-534 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The transfer of solute through a membrane separating two aqueous solutions is studied with the time-dependent diffusion equation for composite media. By introducing new independent and dependent variables it is shown that the differential equations and boundary conditions can be transformed into a dimensionless form which does not explicitly depend on the diffusivities of the media. Laplace transforms are used to derive explicit solutions for the solute concentration as a function of position and time. It is shown that at large time the concentration approaches the equilibrium distribution exponentially. Explicit results are given for the decay time as a function of the parameters of the system. In addition, an accurate and simplified expression is derived for the decay time for the case of small membrane permeability. The accuracy of the analytic solutions for the concentration profiles is tested by comparing them with numerical results obtained by solving the diffusion equations by the method of finite differences. Excellent agreement is found.
    Materialart: Digitale Medien
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  • 144
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    Bulletin of mathematical biology 38 (1976), S. 679-693 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Physiological systems are often modelled by a set of compartments. Alternatively they can be described by the diffusion-convection-reaction equations governing distributed systems. The problem considered here is that of identifying a continuously changing input of some metabolite )tracee), endogenous to the system and hence inaccessible, when a nonlinear or time-varying component is also introduced into the loss parameter, as for example through feedback mechanisms. A tracer is used to determine the steady-state impulse response under time-invariant, linear conditions. A known input of tracer is also administered when the system is driven out of steady state. The integral equations developed utilize the predetermined impulse response, the measured concentrations of both tracer and tracee (output) in some region of the system to estimate the changing loss parameter and the unknown input in a continuous fashion.
    Materialart: Digitale Medien
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  • 145
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    Bulletin of mathematical biology 38 (1976), S. 597-622 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The equilibrium distribution for a generalQth-order multivariate reaction system is studied. The state transition intensity matrix is developed and examples are given for small numbers of reaction components. A closed-form expression for the equilibrium distribution for systems which are symmetric with respect to the order of component reactions is presented. Numerical examples for three component systems are discussed.
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  • 146
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    Bulletin of mathematical biology 38 (1976), S. 623-631 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The model recently proposed by Dreitlein and Smoes for oscillatory kinetic systems is studied. Diffusion of the oscillating species is taken into account, and bounds on the total number of individuals of each species are determined for both two- and three-dimensional finite regions with various boundary conditons applied. It is found that in general the effect of diffusion on the system behavior is to reduce the maximum possible radius of limit cycles. In particular, in some cases global limit cycle behavior is precluded.
    Materialart: Digitale Medien
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  • 147
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    Bulletin of mathematical biology 38 (1976), S. 671-677 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The Kedem-Katchalsky equations for fluid flux across membranes may not be adequate for large solvent flows. In particular, for an example of two membranes in series, it is argued that they would predict physically unreasonable behavior. An alternate equation for solute flow is proposed for a simple sieving membrane. For the same example, this equation predicts more physically reasonable results.
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  • 148
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    Bulletin of mathematical biology 57 (1995), S. 205-227 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The formation of neuronal networks requires axonal growth towards target neutons. A simple set of grammar rules is introduced to describe axonal growth towards target cells situated both at short and long distances from the growing neuron. Growth for short distances is descrbed by growth following the highest gradient of a chemical compound (which is spread by diffusion from the targets). This approach fails to describe long-distance growth, which is addressed by adopting a graph grammar theory for growing trees. With these rules a flexible tool to draw network of neurons by computer can be developed.
    Materialart: Digitale Medien
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  • 149
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    Bulletin of mathematical biology 57 (1995), S. 345-366 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A pair of growth control triads are used to describe coincident tumor growth and liver regeneration after partial hepatectomy. The models are extensions of previous growth control models which describe tumor growth in an unperturbed host (Michelson and Leith, 1991,Bull. math. Biol. 53, 639–656; idem, 1992, Proceedings of the Third International Conference on Communications and Control, Vol. 2, pp. 481–490; idem, 1992,Bull. math. Biol. 55, 993–1011; idem,J. theor. Biol. 169, 327–338). The linkage between the two triads depends upon systemic signals carried by soluble factors, and mathematical descriptors based upon biological first principals are proposed. The sources of the growth factors, their targets and the processing of their signals are investigated. Analyses of equilibrium in the constant coefficients case and simulated growth curves for the dynamic system are presented, and the effects of growth factor-induced mitogenesis and angiogenesis are discussed in particular. A case is made for early and late responses in the coupled control system. The biology of the signal processing paradigm is placed within a new theoretical context and discussed with regard to tumor adaptation, liver differentiation and the development of a tumor hypoxic fraction.
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  • 150
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    Bulletin of mathematical biology 57 (1995), S. 381-399 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We consider the problem of optimal stabilization and control of populations which follow the Leslie model dynamics, within state space and control systems theory and methodology. Various types of culling strategies are formulated and introduced into the Leslie model as control inputs, and their effect on global asymptotic stability is investigated. Our new approach provides answers to several unexplored problems. We show that in general it is possible to achieve a desired stable equilibrium population level, through the design of a class ofshifted-proportional stabilizing culling policies. Further, we formulate general non-linear constrained opitmization problems, for obtaining the cost-optimal policy among this generally infinite class of such stabilizing policies. The theoretical findings are illustrated through the solution of the problem over an infinite planning horizon for a numerical example. A comparative study of the costs and dynamic effects of various culling strategies also supports the mathematical results.
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  • 151
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    Bulletin of mathematical biology 57 (1995), S. 593-617 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new approach for data assimilation, which is based on the adjoint method, but allows the computer code for the adjoint to be constructed directly from the model computer code, is described. This technique is straightforward and reduces the chance of introducing errors in the construction of the adjoint code. Implementation of the technique is illustrated by applying it to a simple predator-prey model in a model fitting mode. A series of identical twin numerical experiments are used to show that this data assimilation approach can successfully recover model parameters as well as initial conditions. However, the ease with which these values are recovered is dependent on the form of the model equations as well as on the type and amount of data that are available. Additional numerical experiments show that sufficient coefficient and parameter recoveries are possible even when the assimilated data contain significant random noise. Thus, for biological systems that can be described by ecosystem models, the adjoint method represents a powerful approach for estimating values for little-known biological parameters, such as initial conditions, growth rates, and mortality rates.
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  • 152
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The effect of group size on behavioral parameters of the Oriental hornet,Vespa orientalis, was assessed experimentally under laboratory conditions. Hornet groups of various sizes (ranging from 1 to 100 individuals per group) comprised of young individuals (0–24 hr of age) devoid of a queen were placed in artificial breeding boxes (ABBs). The following three quantitative parameters were evaluated: the amount and rate of building as a function of the number of hornets in the group, the rate of oviposition as, related to group size and the longevity of hornets as a function of their group size. The probability for the occurrence of these events was similarly considered and additional behavioral parameters were only assessed qualitatively. Results of this investigation revealed a relation between the three mentioned quantitative behavioral parameters and the number of hornets per group. The number of hornets per group was positively related to the extent of building, the number of cells built by a group is $$2\pi \sqrt {group size} $$ , but negatively related to the rate of building. As for the delay of building, a non-monotone relation was found. The relation between number of hornets per group and the oviposition delay was found to be non-monotone; the number of hornets per group and their longevity were found to be inversely related. Discrepanices were recorded on the very small (1–2 individuals) or very large (100 individuals) hornet groups.
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  • 153
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    Bulletin of mathematical biology 57 (1995), S. 527-537 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new method for reconstructing evolutionary relationship among bacteria by use of rRNA sequence data is proposed. The method is based on the concept of fuzzy classification of probabilitiesp(i), p(i/j) andp(i/j*) (i=A,G,C,U) of each sequence. The resulting partition tree shares common features of previous works but has some new peculiarities.
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  • 154
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    Bulletin of mathematical biology 57 (1995), S. 619-630 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
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  • 155
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    Bulletin of mathematical biology 57 (1995), S. 631-650 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We describe the behaviour of motile microorganisms (e.g. flagellates) attracted by “gyrotaxis” to a sinking, non-motile particle (e.g. an algal cell). The model is based on the application of Stokes' solution for the flow field around the settling cell. The volume within which the flagellate is attracted to the sinking particle is determined from the trajectories of the flagellate. The model of gyrotaxis has several applications; these include the colonization of sinking marine snow particles with motile microoganisms and suspension feeding by protozoa.
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  • 156
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    Bulletin of mathematical biology 57 (1995), S. 507-526 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The effect of varying habitat dimensionality on the dynamics of a model predator-prey system is examined using an individual-based simulation. The general results are that in one dimension fluctuations in abundance of prey and predators occur over a large range of spatial scales (extinctions occur over many spatial scales). In two dimensions (and low mobilities of prey and predators) the dynamics become more predictably periodic at local scales and constant at larger scales due to statistical stabilization. In three dimensions, the model can become “phase-locked” with prey and predators displaying oscillations in abundance over large spatial scales.
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  • 157
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    Bulletin of mathematical biology 57 (1995), S. 557-568 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A rather complete model of the gluconeogenic pathway was used, with the known separate pools of mitochondrial and cytosolic oxalacetate, malate and aspartate. The fumarase, malate dehydrogenase and glutamate oxalacetate transaminase reactions were assumed to be isotopically actively reversible, but none at isotopic equilibrium. Malate was assumed to exchange actively between the mitochondrial and cytosol, while aspartate exchange was more limited, in agreement with the known electrogenic nature of aspartate export from the mitochondria. This model was fit to14C data obtained in hepatocyte studies, and to the whole rat14C data obtained by Heath and Rose (Biochem J. 227, 851–876, 1985). The latter data were easily fit to our model, when a single mitochondrial oxalacetate pool was assumed. However, invoking two mitochondrial oxalacetate pools, as proposed by Heath and Rose, with the oxalacetate formed via pyruvate carboxylase preferentially channelled to gluconeogenesis, could not be fit with the known differences in scrambling in glucose and glutamate produced from L[3-14C]lactate.
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  • 158
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    Bulletin of mathematical biology 57 (1995), S. 569-591 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Oscillatory secretion of insulin has been observed in many different experimental preparations ranging from pancreatic islets to the whole pancreas. Here we examine the mathematical features underlying a possible model for oscillatory secretion from the perifused, insulin-secreting cell line, HIT-15. The model includes the kinetics of uptake of glucose by GLUT transporters, the rate of glucose metabolism within the cell, and the effect of glucose on the rate of insulin secretion. Putative feedback by insulin on the rate of glucose transport into the cells is treated phenomenologically and leads to insulin oscillations similar to those observed experimentally in HIT cells. The resulting set of ordinary differential equations is simplified by time-scale analysis to a two-variable set of ordinary differential equations. Because of this simplification we can explore, in great detail, the characteristics of the oscillations and their sensitivity to parameter variation using phase plane analysis.
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  • 159
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    Bulletin of mathematical biology 57 (1995), S. 679-699 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The fluid dynamics of sperm motility near both rigid and elastic walls is studied using the immersed boundary method. Simulations of both single and interacting organisms are presented. In particular, we find that nearby organisms originally undulating with a 90° phase shift may adjust their relative swimming velocities and phase-lock. Comparisons with previous analytical results are also discussed. The tendency of a near-wall to attract organisms is demonstrated.
    Materialart: Digitale Medien
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  • 160
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    Bulletin of mathematical biology 57 (1995), S. 713-731 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The secondary immune response is one of the most important features of immune systems. During the secondary immune response, the immune system can eliminate the antigen, which has been encountered by the individual during the primary invasion, more rapidly and efficiently. Both T and B memory cells contribute to the secondary response. In this paper, we only concentrate on the functions of memory B cells. We explore a model describing the memory contributed by the specific long-lived clone which is maintained by continued stimulation with a small amount of antigens sequestered on the surfaces of the follicular dendritic cells (FDC). The behavior of the secondary response provided by the model can be compared with experimental observations. The model shows that memory B cells indeed play an important role in the secondary response. It is found that a single memory cell in a long-lived clone may not be long-lived. In the present note, the influences of relevant parameters on the secondary response are also explored.
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  • 161
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    Bulletin of mathematical biology 57 (1995), S. 749-782 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A biological system consisting of a population of cells suspended in a liquid substrate is considered. The general problem addressed in the paper is the derivation of the kinetic pattern of population growth as a statistical effect of a very large number of elementary interactions between a single cell and the molecules of nutrient in substrate. Solution of the problem is obtained in the form of equation expressing the population growth ratec as a function of substrate concentration,C s. The analytical expression derived is applied to a real bacterial population (Escherichi coli) and kinetic patterns are theoretically computed. The major findings, expressed roughly, without nuances, are: (i) the concentration of nutrient at the cell membrane,C c, can only be equal to either 0 (for theC s below some threshold valueC *) orC s (forC s〉C *); (ii) the Michaelis-Menten-Monod kinetics observed in experiments is an artifact: the pure (not contaminated by foreign factors) dependence ofc onC s is actually such that the functionc=c(C s) has practically linear increase whenC s〈C *, and is constant,c=c(C *)=const, whenC s〉C *; (iii) the Liebig principle is strictly fulfilled: up to a feasible accuracy of observation, under no circumstances can population growth be limited (controlled) by more than one substrate component—replacement of a limiting component for another one is an instant event rather than a gradual process.
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  • 162
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    Bulletin of mathematical biology 57 (1995), S. 841-881 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We study the equilibrium properties of idiotypically interacting B cell clones in the case where only the differentiation of B cells is affected by idiotypic interactions. Furthermore, we assume that clones may recognize and be stimulated by self antigen in the same fashion as by antiantibodies. For idiotypically interacting pairs of non-autoreactive clones we observe three qualitatively different dynamical regimes. In the first regime, at small antibody production an antibody-free fixed point, the virgin state, is the only attractor of the system. For intermediate antibody production, a symmetric activated state replaces the virgin state as the only attractor of the system. For large antibody production, finally, the symmetric activated state gives way to two asymmetric activated states where one clone suppresses the other clone. If one or both clones in the pair are autoreactive there is no virgin state. However, we still observe the switch from an almost symmetric activated state to two asymmetric activated states. The two asymmetric activated states at high antibody production have profoundly different implications for a self antigen which is recognized by one of the clones of the pair. In the attractor characterized by high autoantibody concentration the self antigen is attacked vigorously by the immune system while in the opposite steady state the tiny amount of autoantibody hardly affects the self antigen. Accordingly, we call the first state the autoimmune state and the second the tolerant state. In the tolerant state the autoreactive clone is down-regulated by its anti-idiotype providing an efficient mechanism to prevent an autoimmune reaction. However, the antibody production required to achieve this anti-idiotypic control of autoantibodies is rather large.
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  • 163
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    Bulletin of mathematical biology 57 (1995), S. 899-929 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract It is widely believed, following the work of Connor and Stevens (1971,J. Physiol. Lond. 214, 31–53) that the ability to fire action potentials over a wide frequency range, especially down to very low rates, is due to the transient, potassium A-current (I A). Using a reduction of the classical Hodgkin-Huxley model, we study the effects ofI A on steady firing rate, especially in the near-threshold regime for the onset of firing. A minimum firing rate of zero corresponds to a homoclinic bifurcation of periodic solutions at a critical level of stimulating current. It requires that the membrane's steady-state current-voltage relation be N-shaped rather than monotonic. For experimentally based genericI A parameters, the model does not fire at arbitrarily low rates, although it can for the more atypicalI A parameters given by Connor and Stevens for the crab axon. When theI A inactivation rate is slow, we find that the transient potassium current can mediate more complex firing patterns, such as periodic bursting in some parameter regimes. The number of spikes per burst increases asg A decreases and as inactivation rate decreases. We also study howI A affects properties of transient voltage responses, such as threshold and firing latency for anodal break excitation. We provide mathematical explanations for several of these dynamic behaviors using bifurcation theory and averaging methods.
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  • 164
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    Bulletin of mathematical biology 57 (1995), S. 939-941 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
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  • 165
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    Bulletin of mathematical biology 57 (1995), S. 945-946 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
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  • 166
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    The journal of Fourier analysis and applications 2 (1995), S. 65-107 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Hardy spaces of analytic functions are studied both on strongly pseudoconvex domains in ℂn and on domains of finite type in ℂ2. Duality theorems, atomic decompositions, and factorization of functions are treated. Mapping properties of certain Hankel operators are studied.
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  • 167
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    The journal of Fourier analysis and applications 2 (1995), S. 181-189 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract As a particular wavelet subspace, the Paley-Wiener space $B_{\pi}$ has both regular and irregular sampling theorems. A regular sampling theorem in general wavelet subspaces has been established for several years. In this paper, we discuss the irregular sampling problem in wavelet subspaces.
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  • 168
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    The journal of Fourier analysis and applications 2 (1995), S. 217-225 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The Adler-Konheim theorem [Proc. Amer. Math. Soc. 13 (1962), 425-428] states that the collection of nth-order autocorrelation functions ${\cal M} = \{M^n(\cdot): n=1,2,\dots\}$ is a complete set of translation invariants for real-valued L1 functions on a locally compact abelian group. It is shown here that there are proper subsets of ${\cal M}$ that also form a complete set of translation invariants, and these subsets are characterized. Specifically, a subset is complete if and only if it contains infinitely many even-order autocorrelation functions. In addition, any infinite subset of $\cal M$ is complete up to a sign. While stated here for functions on $\cal R,$ the proofs presented hold for functions on any locally compact abelian group that is not compact, in particular, on ${\cal R}^n$ and the integer lattice ${\cal Z}^n.$
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  • 169
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    The journal of Fourier analysis and applications 2 (1995), S. 49-64 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract For $k \in {\Bbb N}, k \not= 0,$ define ${\cal F}_kf(\gamma) = \int_{{\Bbb R}^n} f(t)R_k(-2i \pi \gamma.t) \, dt, n\geq 1,$ where $R_k(i\lambda) = e^{i\lambda} - \sum^{k-1}_{j=0} \left(i \lambda \right)^{j} / \left(j~!\right).$ Pointwise estimates and weighted inequalities describing the local Lipschitz continuity of ${\cal F}_kf$ are established. Sufficient conditions are found for the boundedness of ${\cal F}_k$ from $L^p_v$ into $L^q_\mu,$ and a spherical restriction property is proved. A study of the moment subspaces of $L^p_v$ is next developed in the one-variable case, for $1 〈 p 〈 \infty, v$ locally integrable, $v 〉 0$ a.e. It includes a decomposition theorem and a complete classification of all possible sequences of moment subspaces in $L^p_v.$ Characterizations are also given for each class. Applications related to the approximation and decomposition of ${\cal F}_k$ are discussed.
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  • 170
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    The journal of Fourier analysis and applications 2 (1995), S. 135-159 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Often, the Dyadic Wavelet Transform is performed and implemented with the Daubechies wavelets, the Battle-Lemarie wavelets, or the splines wavelets, whereas in continuous-time wavelet decomposition a much larger variety of mother wavelets is used. Maintaining the dyadic time-frequency sampling and the recursive pyramidal computational structure, we present various methods for constructing wavelets ψwanted, with some desired shape and properties and which are associated with semi-orthogonal multiresolution analyses. We explain in detail how to design any desired wavelet, starting from any given multiresolution analysis. We also explicitly derive the formulae of the filter bank structure that implements the designed wavelet. We illustrate these wavelet design techniques with examples that we have programmed with Matlab routines.
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  • 171
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    The journal of Fourier analysis and applications 2 (1995), S. 191-215 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract This paper studies a class of linear operators on spaces of functions of one real variable, which correspond to multiplication by a measurable function under the Weil transform $\Theta.$ These operators are called Weil multipliers, and arise out of the authors' study of Gabor series and radar ambiguity functions. Representation theory provides a natural class of Weil multipliers: the set of doubly periodic functions with absolutely convergent Fourier series, ${\bf A}({\bf T}^2).$ It will be proved that functions in ${\bf A}({\bf T}^2)$ are $L^p$ multipliers for all $1 \leq p \leq 2$ and, therefore, define bounded linear endomorphisms of ${\bf L}^p({\bf R}).$ Also, we record the fact that the Wiener lemma tells us something about the orbit structure of these multipliers acting on function spaces on the Heisenberg nilmanifold. Linear maps that correspond to multiplication by a function under a unitary conjugacy have a particularly simple spectral decomposition, which yields an approximation theory for these operators and provides insight into the foundation of the authors' previous work on approximate orthonormal bases. Finally, the problem of inversion of a multiplier will be analyzed for smooth functions that have a specified structure near their zeros.
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  • 172
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    The journal of Fourier analysis and applications 2 (1995), S. 227-235 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Let $\Omega$ be a smooth domain in R2 containing a polygon D. The inverse conductivity problem to the the elliptic equation ${\rm div}((1+(k-1)\chi_D)\nabla u)=0\ {\rm in }\ \Omega$ is considered. We show that D is uniquely determined from boundary measurements corresponding two appropriately chosen Neumann datas.
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  • 173
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    The journal of Fourier analysis and applications 2 (1995), S. 1-14 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract K.-H. Grochenig and A. Haas asked whether for every expanding integer matrix A ∈ Mn(ℤ) there is a Haar type orthonormal wavelet basis having dilation factor A and translation lattice ℤn. They proved that this is the case when the dimension n = 1. This article shows that this is also the case when the dimension n = 2.
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  • 174
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    The journal of Fourier analysis and applications 2 (1995), S. 15-28 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Let $1 〈 p 〈 \infty, h \in L_p ({\Bbb R}),$ and $f \in L_{p^\prime} ({\Bbb R}).$ Under certain conditions on $h,$ we shall prove that $\int_y^\infty (h_t \ast f)(x)\,dt/t$ converges nontangentially to $f(x_0)$ at $(x_0,0)$ for $a.a.\, x_0.$
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  • 175
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    Circuits, systems and signal processing 14 (1995), S. 669-674 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The stochastic likelihood function [(STO)LF] associated with the narrowband signal processing problem can be concentrated with respect to the signal covariance matrix elements and the noise power. Although this is a known fact, no clear-cut derivation of the concentrated (STO)LF appears to be available in the literature. In this short paper we provide a simple, complete proof of the concentrated (STO)LF formula.
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  • 176
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    Circuits, systems and signal processing 14 (1995), S. 725-734 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We give bounds on the self-sustained limit cycles in fixed-poin implementations of state-variable-form digital filters having general stable system matrices. These bounds, which are period independent and which concern limit cycles due to quantization errors in physical realizations of digital filters, are given in closed form for second-order sections. A numerical comparison shows that the bounds are smaller than corresponding ones reported in the literature. This is due to our use of real similarity transformations.
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  • 177
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    Circuits, systems and signal processing 14 (1995), S. 787-815 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We consider the concept reachability for Polynomial Matrix Descriptions (PMDs); i.e., systems of the form ∑: A(ρ)β(t)=B(ρ)u(t),y(t)=C(ρ)β(t), whereρ:=d/dt the differential operator,A(ρ)=A0+A1 ρ+...+ Av ρ v εR r×r[ρ], AiεR r×r,i=0, 1,..., ν ≥ 1 with rank R A v ≤r B(ρ) =B 0+B 1ρ+...+B σρσ εR r×m[ρ], Bi εR r×m,i=0,1,...,σ ≥ 0 C(ρ)=C0+C1 ρ+...+Cσ1 ρ σ1 εR m1×r[ρ],C i εR m1×r ,i=0, 1,..., σ1 ≥ 0, β(t): (0−, ∞) →R r is the pseudostate of (∑),u(t): [0, ∞) →R m is the control input to (∑), and y(t) is the output of the system (∑). Starting from the fact that generalized state space systems, i.e., systems of the form ∑1: Ex(t)=Ax(t)+ Bu(t), y(t)=Cx(t), whereE εR r×r, rank R E 〈r, A εR r×r,B εR r×m,C εR m1×r represent a particular case of PMDs, we generalize various known results regarding the smooth and impulsive solutions of the homogeneous and the nonhomogeneous system (∑1) to the more general case of PMDs (∑). Relying on the above generalizations we develop a theory regarding the reachability of PMDs using time-domain analysis, which takes into account finite and infinite zeros of the matrix A(s)=L.[A(ρ)]. The present analysis extends in a general way many results previously known only for regular and generalized state space systems.
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  • 178
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    Circuits, systems and signal processing 14 (1995), S. 445-463 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper proposes a scaling and squaring geometric series method along with the inverse-geometric series method for finding discrete-time (continuous-time) structured uncertain linear models from continuous-time (discrete-time) structured uncertain linear systems. The above methods allow the use of well-developed theorems and algorithms in the discrete-time (continuous-time) domain to indirectly solve the continuous-time (discretetime) domain problems. Moreover, these methods enhance the flexibility in modeling and control of a hybrid composite system. It has been shown that the commonly used bilinear approximation model is a specific class of the proposed geometric series model.
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  • 179
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    Circuits, systems and signal processing 14 (1995), S. 525-538 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Of concern is the undistorted propagation of pulse stress waves in long thin bodies. The primary signals are arbitrarily sharp pulses projected along thex-axis. It will be seen that these pulses travel close to the speed of sound in unbounded media. Secondary pulses follow representing interactive disturbances traveling along they-axis. But the process brings out certain anomalies in circuit realizability requirements. These issues, transmission parameters, and coupling between the various signals are studied in detail. The results are supported by experiments.
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  • 180
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    Circuits, systems and signal processing 14 (1995), S. 187-211 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper investigates circuit Markov processes under the standpoint of duality principle.
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  • 181
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    Circuits, systems and signal processing 14 (1995), S. 237-254 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, a high resolution technique for estimating DOAs of spatially close source signals is presented. It is observed that the array manifold over a sector of interest is rank deficient and the dimension of the array manifold space, which is the range space of the array manifold, is less than the number of sensors in the array. The true signal subspace is a subspace in the array manifold space. A novel technique is provided that searches for the signal subspace in this array manifold space. The resulting estimated signal subspace has minimum principal angles with the data signal subspace generated by eigen-decomposing the covariance matrix of the array data vector. It is proved that the proposed estimator is asymptotically consistent and the estimated signal subspace is closer to the true signal subspace than the data signal subspace formed by MUSIC. The proposed novel technique has better performance than the MUSIC algorithm. Its performance is comparable to MLE and MD-MUSIC yet it requires only one-dimensional searches and is computationally much less intense. Simulation results are presented to show the effectiveness of the proposed technique, and comparisons with MUSIC, MLE, and MD-MUSIC algorithms are also included.
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  • 182
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    Circuits, systems and signal processing 14 (1995), S. 351-400 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract High-level synthesis is becoming increasingly important in the area of VLSI CAD. During the last decade, much research has been carried out in this area and some results have been achieved. This paper presents a survey on the state-of-the-art of current high-level synthesis research and applications. Besides basic knowledge, a comprehensive overview has been conducted among the various theories, methods, algorithms, and applications of the existing systems. Their advantages, limitations, and feasibilities are also described. Finally, some points on current status and future directions of high-level synthesis are addressed.
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  • 183
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    Circuits, systems and signal processing 14 (1995), S. 401-414 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper introduces the running kernels that yield recursive structures for time-frequency distributions (TFDs). The running kernels offer important properties not possessed by the commonly used block distribution kernels. The introduced kernels allow an invariance in computations with respect to the extent of the kernel in the time or the lag variable. However, contrary to the wide class of block kernels that satisfy the desired timefrequency (t-f) properties, most recursive (running) time-frequency distributions (RTFDs) violate the marginal and the support properties. This paper considers both the direct and the indirect types of recursion and presents examples for illustration.
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  • 184
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    Circuits, systems and signal processing 14 (1995), S. 465-472 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper the dual topics of robust signal detection and robust estimation of a random variable are considered, where the data may be both dependent and nonstationary. We note that classical saddlepoint techniques for robustness do not readily apply in the dependent and/or nonstationary situation, and thus our results have application in a larger domain than what was feasible heretofore. In addition, our methods make possible the quantitative measurement of robustness and admit essentially arbitrary perturbations in an underlying joint statistical distribution away from the nominal. In particular, our methods show that the presence of dependency can result in a reduction of the robustness of the linear detector by approximately 50% and that appropriate censoring can improve this situation. We also show that, somewhat surprisingly, a weak amount of censoring can actually reduce robustness rather than increase it, even with dependent data that is “almost” independent. This calls into question the common practice, inspired by classical saddlepoint results for independent data, of employing censoring in cases where residual dependency is conceded. When applied to estimation, our work shows that for nominally Gaussian data, the conditional expectation estimator is optimal not only in terms of performance but also robustness (under appropriate performance measures), thus reinforcing the appeal of this estimator. On the other hand, for other performance measures, we also note that the conditional expectation estimator can be completely unrobust, regardless of whether the data is nominally Gaussian or not. Finally, our results establish a bound on estimator robustness.
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  • 185
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    Circuits, systems and signal processing 14 (1995), S. 707-724 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Selection of test nodes is an important phase of the fault dictionary approach. It is demonstrated in this paper that the techniques used for this purpose in other approaches of analog fault diagnosis like fault analysis and fault verification are not in general suitable for the fault dictionary approach. The ambiguity set is a simple and effective concept for choosing test nodes in the context of dictionaries. These sets are formed such that each faulty condition lies in only one ambiguity set. Deviating from this thinking, overlapping ambiguity sets are proposed in this paper, giving rise to a generalized fault dictionary. These sets use information more fully and hence reduce the number of test nodes. The concept of hashing is applied in this paper for selecting test nodes. This gives a linear time algorithm (linear in the number of fault voltage specificationsf′) and it isf′ times faster than the existing methods. It is not possible to select test nodes faster than this. This technique can also be used to select test nodes by the process of elimination of nodes. This is also linear inf′ per node elimination. Even a group of nodes can be eliminated or selected within the same computation. This freedom is not possible with the existing methods.
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  • 186
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    Circuits, systems and signal processing 14 (1995), S. 689-705 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A major reason for the success of linear autoregressive (AR) modeling is that Kolmogrorov proved that every linear system could be represented by a linear AR model of infinite order. The computation of a finite order AR approximation is, of course, the practical goal. In this paper, we prove that every nonlinear system with a Volterra series expansion can be represented as a nonlinear AR model of infinite order. Our method shows how an approximation to any desired order and degree can be achieved.
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  • 187
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    Bulletin of mathematical biology 42 (1980), S. 1-15 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A computational model to predict deposition of a wide variety of particulate pollutants in several species of mammals is presented. The model incorporates breathing pattern and detailed anatomical models of the respiratory tract based on extensive morphometric measurements of individual airways. The predicted deposition from this general model is in close agreement with observed deposition of monodisperse aerosols in rats. Particle size and density and respiratory breathing patterns are the critical parameters affecting regional deposition.
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  • 188
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    Bulletin of mathematical biology 42 (1980), S. 17-36 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A theory of antigen-antibody induced particulate aggregation is developed by investigating the stability of model systems of particles. Conditions for the formation of large aggregates are derived by imposing the requirement that at equilibrium a statistically significant number of redundant bonds would occur in a reduced monomer-dimer model system. A relationship is obtained which predicts the fractional agglutination in the reduced dimer system as a function of the antigen, antibody and particulate concentrations: $$\frac{g}{{2f c_0 (1 - g)^{2^ - } }} = \frac{{s_1 }}{r} + \frac{{s_1 s_2 }}{{2!r^2 }} + ... + \frac{{s_1 s_2 ...s_j }}{{j!r^j }},$$ wherec 0 is the initial concentration of monomer,f is a proximity factor,g is the fractional agglutination,s i is the average rate of formation of theith bond from an (i−1)th bound dimer, andr is the average rate of dissociation of a single antibody-antigen bond.
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  • 189
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    Bulletin of mathematical biology 42 (1980), S. 37-56 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The roles of the concentrations of the three interacting constituents in the aggregation process (antibodies, antigens and particulates) are analyzed in detail. It is shown that the basic equation derived in Part I is consistent over a broad range of conditions with experimental findings previously reported.
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  • 190
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    Bulletin of mathematical biology 42 (1980), S. 57-78 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A general mathematical model describing the biochemical interactions of the hormones luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH) and testosterone (T) in the male is presented. The model structure consists of a negative feedback system of three ordinary differential equations, in which the qualitative behavior is either a stable constant equilibrium solution or oscillatory solutions. A specific realization of the model is used to describe the experimental observations of pulsatile hormone release, its experimental suppression, the onset of puberty, the effects of castration, and several other qualitative and quantitative results. This model is presented as a first step in understanding the physicochemical interactions of the hypothalamic-pituitary-gonadal axis.
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    Bulletin of mathematical biology 42 (1980), S. 79-94 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Based upon the transition rate equation of dipoles in the membrane, we deal with two important aspects of interaction of nerve signals: (1) conditions for nerve excitation and (2) frequency spectrum analysis of nerve impulse. Interrelations between signal amplitudes and frequencies are formulated in detail. There are several important conclusions which can be drawn from our calculations. First, toexcite the nerve, low frequencies are generally more effective than high frequencies. Second, tosedate the nerve (i.e. to suppress undesired activities), high frequencies would suit better. Third, harmonics produced through interactions of nerve signals are not necessarily weaker than the fundamental frequencies. The great significance of our theory is that it indicates in principle the feasibility to alter or rewrite the information contents of a nerve message in our body by applying stimulations of appropriate strengths and frequencies. Thus, the theory provides a physical basis and hence some understanding for a new branch of medicine—neuro therapy such as Nogier's auriculotherapy, Lamy's phonophoresis, Voll's electroacupuncture and the fast rising TENS (transcutaneous electro-neuro stimulation).
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 192
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 107-117 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new physical property, called resonance of the B-type is hypothetically attached to the λ =546 nm irradiated crystalline (small) molecules. In this respect an up or down configuration is assumed for those states obtained through irradiation times that are multiples of 5 sec. With these assumptions, the cellular receptors that may detect these states appear to belong to three classes: the up, down and alternatively mixed up-down. Using the classic formalism of eigenvectors and eigenvalues, a simple spectroscopic type of formula is derived, through which all the possible states of the above characteristic may be obtained.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 193
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 119-130 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A model of ecosystems with migration is proposed from the viewpoint of flow. This model explains the following two points: (1) How the density-dependent terms in population dynamics arise as a consequence of migration. (2) How the ecosystem exhibits a hierarchy in energy per unit biomass.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 194
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 143-145 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 195
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 95-106 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract For precise boundary conditions of biological relevance, it is proved that the steadily propagating plane-wave solution to the Fisher equation requires the unique (eigenvalue) velocity of advance 2(Df)1/2, whereD is the diffusivity of the mutant species andf is the frequency of selection in favor of the mutant. This rigorous result shows that a so-called “wrong equation”, i.e. one which differs from Fisher's by a term that is seemingly inconsequential for certain initial conditions, cannot be employed readily to obtain approximate solutions to Fisher's, for the two equations will often have qualitatively different manifolds of exact solutions. It is noted that the Fisher equation itself may be inappropriate in certain biological contexts owing to the manifest instability of the lowerconcentration uniform equilibrium state (UES). Depicting the persistence of a mutantdeficient spatial pocket, an exact steady-state solution to the Fisher equation is presented. As an alternative and perhaps more faithful model equation for the propagation of certain species properties through a homogeneous population, we consider a reaction-diffusion equation that features a cubic-polynomial rate expression in the species concentration, with two stable UES and one intermediate unstable UES. This equation admits a remarkably simple exact analytical solution to the steadily propagating plane-wave eigenvalue problem. In the latter solution, the sign of the eigenvelocity is such that the wave propagates to yield the “preferred” stable UES (namely, the one further removed from the unstable intermediate UES) at all spatial points ast→∞. The cubic-polynomial equation also admits an exact steady-state solution for a mutant-deficient or mutant-isolated spatial pocket. Finally, the perpetuating growth of a mutant population from an arbitrary localized initial distribution, a mathematical problem analogous to that for ignition in laminar flame theory, is studied by applying differential inequality analysis, and rigorous sufficient conditions for extinction are derived here.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 196
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 191-220 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The binding of mono-, di- and trivalent cations to negatively charged surfaces is studied within the framework of a modified Gouy-Chapman equation. For any given combination of ions of the above valences, the existence and uniqueness of the solution for the surface potential is shown. The treatment provides the surface potential and charge density. For a system containing only monovalent and divalent ions, analytical solutions are given. When trivalent ions are also present, a procedure based on numerical integration is described. The distance dependence of the electrostatic potential for planar surfaces is given. The calculations provide the amount of cations tightly bound and the amount trapped in the double layer region. The competition between cations for binding to surfaces is elucidated.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 197
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 221-238 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This paper deals with a model describing the behavior of barium-treatedApalysia neurons. The model is represented by a dynamical system, so-called “complete system”, defined in R4 and depending on a small parameter. The study of this system under zero membrane current conditions was performed with the use of the qualitative theory of singular perturbations. We show that this system has a stable periodic solution of the discontinuous type when the small parameter tends to 0+. A reduced system defined in R3, associated to the complete system was also studied: it corresponds to a constant activation of the inward current. We demonstrate that the corresponding hypothetical cell remains silent under zero current conditions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 198
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In the study of chemical modification of enzymes and other biologically active proteins, plots of fractional residual activity as a function of number of groups modified per enzyme molecule are often used to establish a correlation between the chemical modification and enzyme inactivation reactions and to determine the stoichiometry of the modification reaction. This paper presents a critical examination of the underlying theoretical framework of such graphs. Whereas these plots are usually presented as linear functions, it is shown here that the general equation describing the relationship between inactivation and modification contains an exponential term; therefore, in the general case, the plot is actually a curve. It is suggested that caution be exercised in the interpretation of such plots and that equations such as those derived in the text be used to fit theoretical curves to the data, in order to maximize the information gained from chemical modification experiments.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 199
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 257-265 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This communiction argues that so-called “hermaphroditic” tracer systems, which are neither open nor closed, do not exist physically. The argument is based on the assumption that any observable (possibly nonhomogeneous) macroscopic compartment can be approximated by a compartmentC with a finite number of entry points for the tracer, each associated with an abstract subcompartment ofC. It is shown that the “hermaphroditic” property requires that the mean waiting time be infinite in at least one of the subcompartments, or in a subcompartment elsewhere in the system. A subcompartment with infinite mean waiting time must have some sort of memory, of infinite duration, which knows how long a given particle has been retained, however long that is, and thereby determines its probability of departure. Assuming, as seems likely, that no physical basis exists for such an infinite memory, it follows that “hermaphroditic” systems do not exist.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 200
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 42 (1980), S. 273-274 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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