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  • 1995-1999  (127.748)
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 205-207 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 161-192 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In order to evaluate the effect of anatomic asymmetries on the gas concentration distribution in the pulmonary airways, a Monte Carlo simulation of combined bulk flow and molecular diffusion was carried out in a realistic distal airway model (Parkeret al., 1971). This airway model, composed of branches distal to the 0.5-ram diameter airways, contained an upper symmetric segment consisting of four generations of conducting airways and a lower asymmetric segment of alveolar ducts and sacs arranged in five transport paths of varying lengths. In accounting for the volume increases of these ducts and sacs occurring during normal respiration, uniform alveolar filling rates and a fixed length-to-diameter ratio of all airways were assumed. For a pulse injection of inert tracer gas, the simulation was employed to determine the longitudinal concentration profiles in the conducting airways. In the alveolated airways, not only were the longitudinal profiles determined along each path, but radial transport from the core to the periphery of the airways was considered. The results of the simulations indicate that geometric asymmetries alone contribute substantially to regional concentration variations in the distal airways. For example, when a gas bolus is injected at mid*inspiration, there are concentration differences as great as 40% between two points along different transport paths located equi-distant from the proximal end of the model. As viewed from the terminal end of the model (acinus), average concentration differences as large as 6-to-1 exist between the longest and shortest transport paths respectively for gas boli introduced near the end of inspiration. The results further indicate because of large radial diffusion rates, no significant concentration differences exist between the periphery a-ld the central core of alveolated airways. Simulation of the expired concentration profiles indicate that boll injected very late during inspiration exhibit a sloping tail, unlike the earlier injected boll whose tails are virtually horizontal. Through the use of superposition teehniqnes, it was found that these sloping tails correspond to an alveolar slope of 1.5 vol% between 750 and 1250 ml expired for a continuous washing of tracer. This result is in disagreement with other transport analyses which did not directly account for the effect of geometric asymmetries.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Assuming a spherical geometry for the left ventricle, passive elastic stiffness-stress relations have been obtained on the basis of linear elasticity theory and large deformation theory. Employing pressure-volume aata taken from rat hearts of various age groups, it is shown that young rat heart muscle (1 month) is stiffer than either adult (7 months) or old rat heart muscle (17 months). Although the qualitative results are similar for both elasticity theories, the large deformation theory gave results in closer agreement with those obtained from papillary muscle studies. These results imply that stiffness of muscleper se can be assessed from left ventricular pressure-volume data.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 277-293 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Deliberate evaluation of the quantum theory of nerve excitation is made by comparing it with Hill's theory in fitting the experimental data on threshold-frequency relation, optimum frequency (v0) for nerve excitation and strength-duration relation. Decrease of v0 and increase of all the time constants (Hill's λ andk, Wei'sT 2 and spike durationw) with decreasing temperature are interpreted on the basis of the dipole relaxation timeT 2 but inexplicable from Hill's theory or any other existing theory. The closeness ofk,T 2 andw values is explained. A variety of experimental results obtained by others is discussed. Finally, a comparison is made between the Hodgkin-Huxley equations and the quantum theory. Most of the facts (electrical and non-electrical) tend to support the thesis that nerve excitation is a macroscopic expression of quantum transitions of dipoles between energy states.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 317-319 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In the periodic Leslie model the asymptotic period of total population is a divisor of the asymptotic period of the population vector. Under reasonable circumstances these periods are identical.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 305-315 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A number of biological branching systems, such as the bronchial and pulmonary arterial trees, are being investigated in an ongoing study in order to define their physiological properties. The technique involves the description of branching trees by the use of hierarchical systems of ordering, especially those described by Horsfield and by Strahler. During this work some mathematical properties of branching trees were demonstrated and these are described in this paper.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 323-324 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 209-217 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 387-400 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Luteinizing hormone (LH) is secreted continuously from the anterior pituitary gland. The concentration in the blood of this gonadotropic hormone plays a regulatory role in the development of puberty in both sexes, in the induction of ovulation in females, and in the production of testosterone in males. The secretion of LH is in turn controlled by luteinizing hormone releasing hormone (LHRH) secreted by the hypothalamus. LH and LHRH are removed from the blood by degradation and excretion. This hormonal system is modelled by a system of ordinary differential equations based upon specific physiological and biochemical assumptions current among experimentalists in this field. The one exception is the assumption that LHRH may bind reversibly to a serum protein; an analysis of the data shows that this or a similar mechanism is a crucial specification. Data on the serum levels of LH and LHRH in two human subjects were fitted using the model. The data consist of the transients and subsequent decays created by a bolus intravenous injection of LHRH.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 401-413 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A thick-wall incompressible, elastic sphere was used as a model for the diastolic rat left ventricle. A model for myocardial nonhomogeneity was derived assuming that fiber (circumferential) stress was independent of position in the ventricular wall. The theoretical implications of the resulting constitutive relations together with the spherical model were analyzed in the context of large deformation elasticity theory. It was found that muscle stiffness at a given level of uniaxial stress increased monotonically from the endocardium to the epicardium. In addition, fiber stress was found to be essentially a linear function of transmural pressure above a pressure of 6 g/cm2. It was also shown theoretically that neglecting the nonhomogeneity of the myocardium resulted in a state of stress which differed significantly from that predicted by the nonhomogeneous model. For example, at a transmural pressure of 14 g/cm2, fiber stress in the nonhomogenous model was equal to 17 g/cm2 while fiber stress in the homogeneous model varied between 100 g/cm2 at the endocardial surface and 2 g/cm2 at the epicardial surface. The change in muscle stiffness with position which characterized the nonhomogeneous model also tended to linearize the highly curvilinear radial stress distribution predicted by the homogeneous model at a given transmural pressure.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 435-444 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The phenomenon of axonal transport has been well documented (Ochs, 971; Lasek, 1970; and Grafstein, 1967). In a previous paper, we showed how diffusion alone could not account for this process. In this report we show that convection or convection with diffusion can account for the observed build-up of material. By including a first-order catabolic sequestration term, we are able to offer an understanding of the several apparent rates of transport with the same underlying velocity and variable sequestration.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 459-465 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract It is known that the Lotka-Volterra coupled nonlinear differential equations for a two-species prey-predator ecosystem possess a periodic solution, although its exact form is not yet obtained analytically. The conventional linearization approximation for solving these nonlinear equations leads to a harmonic oscillator whose frequency depends only on the intraspecific coefficients. We propose here a prescription for obtaining nonlinear correction to the linear frequency by using the Hamilton-Jacobi canonical formalism of classical mechanics. It is found that the first-order correction, which also involves interspecific parameters, exhibits the basic qualitative features of the nonlinearity.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 467-478 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Environmental safety testing typically requires procedures for extrapolating from the relatively high experimental to the very low use doses of potentially harmful substances. In the present paper, a stochastic mammillary compartmental model for environmental safety testing is proposed and extrapolation procedures based on its dose-response relationship are developed. The proposed model is a direct generalization of one of the basic safety models, the one-hit model, in that a harmful reaction is assumed to occur if at any time any of the peripheral compartments attains a specified threshold of particles. Consideration of a closed model yields an upper bound on the probability of attaining a certain threshold level, thus providing a conservative procedure for extrapolating to a low dose, while a lower bound obtained from a related open model provides a useful monitoring device as to the sharpness of the upper, bound. The extrapolation procedure is illustrated with simulated data and approximations for initial values are developed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 505-516 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract By using chromosome images as a framework, algorithms for finding most dissimilar images are presented and illustrated by examples. In terms of angles, a chromosome image consists of two exterior biangles and two interior biangles. Biangles are defined and classified into 180° biangles, 〉180° biangles and 〈180° biangles. The dissimilarity of biangles and its geometric interpretation together with various properties of biangles are also presented. The results may have useful applications in pattern recognition, scene analysis, information storage and retrieval, artificial intelligence and fuzzy set theory.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 38 (1976), S. 517-526 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The Volterra equations which represent competitions between two species are utilized to examine the phenomenon of boundary formation between two species of plants. The set of stable stationary points for these equations is determined and is illustrated in a product space of parameters and dynamical variables. The stages of boundary appearance and succession are visualized by considering slow changes of the parameters as functions of time and space.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 40 (1978), S. 45-58 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract For certain environments, the Darwinian model allows unique prediction of a function that any surviving system adapted to such an environment has to perform. This is the case for those environments that determine a “survival functional” of position in space-time of known shape. Purely temporal survival functionals can be distinguished from spatial and mixed ones. In each case, there exists an optimum path in combined physical and (reduced) metabolic space. Dependent on the admissible error, approximate solutions of different complexity are sufficient. All solutions possess an afferent, a central, and an efferent part. Within this general frame, specific, “probably simplest”, solutions are proposed for adaptive chemotaxis, insect locomotion, lower vertebrates locomotion, higher vertebrates locomotion, chronobiological systems, and immune systems, respectively—or rather, for the underlying functionals.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 40 (1978), S. 59-77 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Mathematical models afford a procedure of unifying concepts and hypotheses by expressing quantitative relationships between observables. The model presented indicates the roles of both insulin and glucagon as regulators of blood glucose, albeit in different ranges of the blood glucose concentrations. Insulin secretion is induced during hyperglycemia, while glucagon secretion results during hypoglycemia. These are demonstrated by simulations of a mathematical model conformed to data from the oral glucose tolerance test and the insulin infusion test in normal control subjects and stable and unstable diabetic patients. The model studies suggest the parameters could prove of value in quantifying the diabetic condition by indicating the degree of instability.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 40 (1978), S. 123-131 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A model for the dynamics of a single-species population whose birth rate depends on densities of previous generations is introduced. A difference equation formulation is proposed and the solutions classified for the various parameter values. Data from an experimental population of mice growing in limited space is cited and compared with the model predictions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 40 (1978), S. 161-182 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract All soft tissues are modeled as either one-dimensionalstrings, two-dimensionalmembranes, or three-dimensionalsolids. Attention is restricted to tissues in which one of the principal stress components is large and positive in comparison with the other negligible components. Results indicate the following: (1) If a deformed string isconstrained to lie on a surface and is free of tangential pressure, the tension is carried by rays which are geodesics of the surface. If a string or membrane isfree to deform in space without normal pressure, the tension rays are straight lines. If a membrane deforms without tangential surface loads, the tension rays are always geodesics on the deformed surface. If a solid deforms without body forces, the tension rays are straight lines. (2) The stress in a string is a constant if the string is free of tangential pressure and has constant cross-sectional area. The stress in flat tension fields free of tangential surface loads decays inversely with distance along a tension ray from the edge of regression. The stress in a spherically symmetric tension field free of body forces decays inversely with the square of the distance from the center of the sphere. (3) Stress singularities can occur in soft tissues, such as at the corners of a closed rectangular hole in a flat membrane strip. (4) The tension rays in the torsion of soft annular membranes are more steeply inclined from the radial direction than the tension rays for hard metals equally displaced.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 23-41 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We consider a host-solitary parasitoid system with three categories of individuals: parasitoids, healthy hosts and parasitized hosts. Parasitoids are assumed to discriminate perfectly between the two kinds of hosts and they can reject those which are already parasitized. If parasitoids systematically accept or reject superparasitism or behave randomly, the system is always unstable. Using an optimal foraging model, we determine the behavior of parasitoids which leads to maximization of the instantaneous reproductive rate. When following this adaptive decision rule, parasitoids accept or refuse superparasitism according to the densities of both healthy and parasitized hosts. We study the dynamics of the system when parasitoids follow the optimal rule and show that under certain conditions it possesses a locally stable equilibrium point. In addition, our model predicts that at equilibrium parasitoids show partial preferences for superparasitism.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 21
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 205-232 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A system of differential equations for the control of tumor growth cells in a cycle nonspecific chemotherapy is analyzed. Spontaneously acquired drug resistance is taken into account, and a criterion for the selection of chemotherapeutic treatment is used. This criterion purports to describe the possibility of improvement of the patient's health when treatment is discontinued. Contrary to our early results which also take drug resistance into account, in this context strategies of continuous chemotherapy in which rest periods take part may be better than maximum drug concentration throughout the treatment (which appears to be in accordance with clinical practice). This bears out our previous conjecture that when drug resistance is accounted for, the imperfections in the usual modelling of treatment criteria, which in general do not allow for patient recuperation, ruled out the possibility of rest periods in optimal continuous chemotherapy.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 22
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 255-262 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A logistic density-dependent matrix model is developed in which the matrices contain only parameters and recruitment is a function of adult population density. The model was applied to simulate introductions of white-tailed deer into an area; the fitted model predicted a carrying capacity of 215 deer, which was close to the observed carrying capacity of 220 deer. The rate of population increase depends on the dominant eigenvalue of the Leslie matrix, and the age structure of the simulated population approaches a stable age distribution at the carrying capacity, which was similar to that generated by the Leslie matrix. The logistic equation has been applied to study many phenomena, and the matrix model can be applied to these same processes. For example, random variation can be added to life history parameters, and population abundances generated with random effects on fecundity show both the affect of annual variation in fecundity and a longer-term pattern resulting from the age structure.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 23
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 399-406 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 24
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 707-724 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. Spontaneously acquired drug resistance is accounted for, as well as the evolution in time of normal cells. In addition, optimization of conflicting objectives forms the aim of the chemotherapeutic treatment. For general cell growth, some results are given, whereas for the special case of Malthusian (exponential) growth of tumor cells and rather general growth rate for normal cells, the optimal strategy is worked out. The latter, from the clinical standpoint, corresponds to maximum drug concentration throughout the treatment.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 25
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 787-807 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 809-831 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This study examines the influence of various host-feeding patterns on host-parasitoid population dynamics. The following types of host-feeding patterns are considered: concurrent and non-destructive, non-concurrent and non-destructive, and non-concurrent and destructive. The host-parasitoid population dynamics is described by the Lotka-Volterra continuous-time model. This study shows that when parasitoids behave optimally, i.e. they maximize their fitness measured by the instantaneous per capita growth rate, the non-destructive type of host feeding stabilizes host-parasitoid dynamics. Other types of host feeding, i.e. destructive, concurrent, or non-concurrent, do not qualitatively change the neutral stability of the Lotka-Volterra model. Moreover, it is shown that the pattern of host feeding which maximizes parasitoid fitness is either non-concurrent and destructive, or concurrent and non-destructive host feeding, depending on the host abundance and parameters of the model. The effects of the adaptive choice of host-feeding patterns on host-parasitoid population dynamics are discussed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 931-952 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Game theory has had remarkable success as a framework for the discussion of animal behaviour and evolution. It suggested new interpretations and prompted new observational studies. Most of this work has been done with 2-player games. That is the individuals of a population compete in pairwise interactions. While this is often the case in nature, it is not exclusively so. Here we introduce a class of models for situations in which more than two (possibly very many) individuals compete simultaneously. It is shown that the solutions (i.e. the behaviour which may be expected to be observable for long periods) are more complex than for 2-player games. The concluding section lists some of the new phenomena which can occur.
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  • 28
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A method allowing to measure the inhomogeneous distribution of purines/pyrimidines in nucleotide sequences is developed. We show that this measure relates to the coding or non-coding character of the considered sequence. Coding sequences present a near to the random Pu or Py distribution. This property is shared by both protein-coding DNA and functional RNA-coding DNA. Non-coding sequences present a highly clustered inhomogeneity. We propose the hypothesis, corroborated with appropriate computer simulations, that this is due to the action of various transposition events accumulated for long time periods.
    Materialart: Digitale Medien
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  • 29
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1047-1075 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The potential generated in the smooth muscle of the vas deferens on release of a quantum of transmitter from a varicosity was analyzed using a three-dimensional bidomain continuum model. Current was injected at the origin of the bidomain; this current had the temporal characteristics of the junctional current. The membrane potential, intracellular potential, and extracellular potential, as well as the extracellular current, were then calculated throughout the bidomain at different times. Calculations were performed to show the effect of changing the anisotropy ratios of the intracellular and extracellular conductivities on the spread of current and potential in each of the three dimensions. These results provide a theoretical framework for ascertaining the time course of transmitter interaction at a varicosity following the secretion of a quantum of transmitter.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 30
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1145-1154 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Parabolic growth invariably results in the survival of all competing types. Under the constraint of constant total concentration, there is a unique equilibrium in the simplex interior, which is asymptotically stable inside the whole simplex. The appropriate Lyapunov function is obtained in terms of the excess productivity which is shown to be maximized for the competitive system with fractional order kinetics. Claims to the contrary are refuted.
    Materialart: Digitale Medien
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  • 31
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1191-1201 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 32
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 195-196 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 101-129 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Due to the increasing importance of the extracellular matrix in many biological problems, in this paper we develop a model for fibroblast and collagen orientation with the ultimate objective of understanding how fibroblasts form and remodel the extracellular matrix, in particular its collagen component. The model uses integrodifferential equations to describe the interaction between the cells and fibers at a point in space with various orientations. The equations are studied both analytically and numerically to discover different types of solutions and their behavior. In particular we examine solutions where all the fibroblasts and collagen have discrete orientations, a localized continuum of orientations and a continuous distribution of orientations with several maxima. The effect of altering the parameters in the system is explored, including the angular diffusion coefficient for the fibroblasts, as well as the strength and range of the interaction between fibroblasts and collagen. We find the initial conditions and the range of influence between the collagen and the fibroblasts are the two factors which determine the behavior of the solutions. The implications of this for wound healing and cancer are discussed including the conclusion that the major factor in determining the degree of scarring is the initial deposition of collagen.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 215-230 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This paper considers the time to extinction for a stochastic epidemic model of SEIR form without replacement of susceptibles. It first shows how previous rigorous results can be heuristically explained in terms of the more transparent dynamics of an approximating deterministic system. The model is then extended to include a host population structured into patches, with weak nearest-neighbour mixing of infection. It is shown, by considering the approximating deterministic system, that the expected time to extinction in a population of n + 1 patches each of size N is of the form a log N + bn, provided that N 〉 N c where N c is a critical patch size below which transits are unlikely to occur. This corresponds to the simple decomposition of the time of an epidemic into the time it takes to spread through one patch plus the time it takes to transit to each of n successive patches. Expressions for this threshold and the coefficients of the time to extinction are given in terms of the transmission parameters of infection and the coupling strength between patches. These expressions are compared with numerical results using parameters relevant to a study of phocine distemper virus in North Sea seals, and the agreement is found to be good for large and small N. In the region when N ≈ N c , where transits may or may not occur, interesting transitional behaviour is seen, leading to a non-monotonicity of the extinction time as a function of N.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 409-415 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 36
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 355-372 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract When directly transmitted infectious diseases are modeled assuming an everlasting induced immunity (and constant contact rate), there are well-established formulas to deal with, which is not true if we include the loss of induced immunity. In general, the immunity induced by the disease is everlasting. We propose a model considering the loss of immunity and present methods for the estimation of two epidemiological parameters: the force of infection and the basic reproduction ratio. We also analyze the effects of the loss of immunity on these parameters. Based on these results, we conclude that reinfection can play an important role in highly vaccinated populations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 449-475 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We studied mathematical models for the length distributions of actin filaments under the effects of polymerization/depolymerization, and fragmentation. In this paper, we emphasize the effects of these two processes acting alone. In this case, simple discrete and continuous models can be derived and solved explicitly (in several special cases), making the problem interesting from a modeling and pedagogical point of view. In a companion paper (Ermentrout and Edelstein-Keshet, 1998, Bull. Math. Biol. 60, 477–503) we investigate what happens when the processes act together, with particular attention to fragmentation by gelsolin, and with a greater level of biological detail.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 197-213 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A possible experimental design for combination experiments is to compare the doseresponse curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of doseresponse relations both for the dose-additivity (Loewe additivity) and for the independence (Bliss independence) criteria for defining zero interaction. Parallelism between doseresponse curves of a single agent and those of the same agent in the presence of a fixed amount of another one is found for the Loewe-additivity criterion for linear doseresponse relations. For nonlinear relations, one has to differentiate between effect parallelism (parallel shift on the effect scale) and dose parallelism (parallel shift on the dose scale). In the case of Loewe additivity, zero-interaction dose parallelism is found for power, Weibull, median-effect and logistic doseresponse relations, given that special parameter relationships are fulfilled. The mechanistic model of competitive interaction exhibits dose parallelism but not effect parallelism for Loewe additivity. Bliss independence and Loewe additivity lead to identical results for exponential doseresponse curves. This is the only case for which dose parallelism was found for Bliss independence. Parallelism between single-agent doseresponse relations and Loewe additivity mixture relations is found for examples with a fixed doseratio design. However, this is again not a general property of the design adopted but holds only if special conditions are fulfilled. The comparison of combination doseresponse curves with single-agent relations has to be performed taking into account both potency and shape parameters. The results of this analysis lead to the conclusion that parallelism between zero interaction combination and single-agent doseresponse relations is found only for special cases and cannot be used as a general criterion for defining zero-interaction in combined-action assessment even if the correct potency shift is taken into account.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 39
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 763-785 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The purpose of this study was to investigate strategies in the monotherapy treatment of HIV infection in the presence of drug-resistant (mutant) strains. A mathematical system is developed to model resistance in HIV chemotherapy. It includes the key players in the immune response to HIV infection: virus and both uninfected CD4+ and infected CD4+ T-cell populations. We model the latent and progressive stages of the disease, and then introduce monotherapy treatment. The model is a system of differential equations describing the interaction of two distinct classes of HIV—drug-sensitive (wild type) and drug-resistant (mutant)—with lymphocytes in the peripheral blood. We then introduce chemotherapy effects. In the absence of treatment, the model produces the three types of qualitative clinical behavior—anuninfected steady state, andinfected steady state (latency), andprogression to AIDS. Simulation of treatment is provided for monotherapy, during theprogression to AIDS state, in the consideration of resistance effects. Treatment benefit is based on an increase or retention in CD4+ T-cell counts together with a low viral titer. We explore the following treatment approaches: an antiviral drug which reduces viral infectivity that is administered early—when the CD4+ T-cell count is ≥300/mm3, and late—when the CD4+ T-cell count is less than 300/mm3. We compare all results with data. When treatment is initiated during the progression to AIDS state, treatment prevents T-cell collapse, but gradually loses effectiveness due to drug resistance. We hypothesize that it is the careful balance of mutant and wild-type HIV strains which provides the greatest prolonged benefit from treatment. This is best achieved when treatment is initiated when the CD4+ T-cell counts are greater than 250/mm3, but less than 400/mm3 in this model (i.e. not too early, not too late). These results are supported by clinical data. The work is novel in that it is the first model to accurately simultate data before, during and after monotherapy treatment. Our model also provides insight into recent clinical results, as well as suggests plausible guidelines for clinical testing in the monotherapy of HIV infection.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 833-856 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A mathematical model which describes adhesion of bacteria to host cell lines is presented. The model is flexible enough to account for the following situations: extracellular bacteria are either in exponential or in stationary phase. Adhesion is described as a reversible binding process in which the bacteria attach to or detach from specific receptors uniformly distributed on the cell surface. In turn, attached bacteria can either replicate or, conversely, they are restrained to remain in stationary phase. In the first case, however, we must consider the problem of whether the decrease of unoccupied receptors as adhesion progresses imposes a limit to the replicating capacity of the attached bacteria. The effect exerted by the multiplicity of infection (MOI), i.e. the ratio of the number of bacteria to the number of host cells, on the process of adhesion is also contemplated by the model. This has revealed that experiments performed at the same values of MOI can show completely different levels of adhered bacteria, depending on the number of host cells in the assays. This finding demonstrates that the report of the MOI values is insufficient to characterize comparative studies of bacterial adhesion since it could lead to a misunderstanding of the corresponding data. Simplified models based on the steady-state approximation and in equilibrium analysis by means of a Lagmuir adsorption isotherm for the attached bacteria are also discussed. This allows us to define the adhesion coefficient (β) in a given bacterium-cell system so that, with the exception of those systems where these coefficients cannot be defined, larger values of β are related to a greater adhesion capacity. An overview of the procedures to perform quantitative adhesion data analysis is outlined. Finally, theoretical predictions are compared with experimental results from the literature.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 41
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 897-910 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new measure of toxicity based on stochastic modelling of single photon-counting processes, representing time-resolved phagocyte luminescence of xenobiotic-perturbed human neutrophils, has been constructed. The stochastic measure of toxicity has been verified by the QSAR method, and then compared and contrasted with the traditional toxicity measure used in bio- and chemiluminescent research. Phenol and benzene homologues were chosen as perturbers due to their importance from the viewpoint of ecotoxicology and occupational medicine.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 953-973 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We describe a mathematical model of the flow and deformation in a human teat. Our aim is to compare the theoretical milk yield during infant breast feeding with that obtained through the use of a breast pump. Infants use a peristaltic motion of the tongue, along with some suction, to extract milk, whereas breast pumps use a cyclic pattern of suction only. Our model is based on quasi-linear poroelasticity whereby the teat is modelled as a cylindrical porous elastic material saturated with fluid. We impose a cyclic axial suction pressure difference across the teat and impose a radial compressive force moving along the teat which mimics infant suckling. This is compared to the case of cyclic and steady pumping only which models the action of breast pumps. The results illustrate that there is an optimal time to apply the compressive force during the suction cycle that will increase the flow rate in our theoretical teat. The model and results may be of use in the future design of effective breast pumps.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 993-1012 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In the present work, we study the propagation of solitary waves in a prestressed thick walled elastic tube filled with an incompressible inviscid fluid. In order to include the geometric dispersion in the analysis the wall inertia and shear deformation effects are taken into account for the inner pressure-cross-sectional area relation. Using the reductive perturbation technique, the propagation of weakly non-linear waves in the long-wave approximation is examined. It is shown that, contrary to thin tube theories, the present approach makes it possible to have solitary waves even for a Mooney-Rivlin (M-R) material. Due to dependence of the coefficients of the governing Korteweg-deVries equation on initial deformation, the solution profile changes with inner pressure and the axial stretch. The variation of wave profiles for a class of elastic materals are depicted in graphical forms. As might be seen from these illustrations, with increasing thickness ratio, the profile of solitary wave is steepened for a M-R material but it is broadened for biological tissues.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1077-1100 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Adult dermal wounds, in contrast to fetal wounds, heal with the formation of scar tissue. A crucial factor in determining the degree of scarring is the ratio of types I and III collagen, which regulates the diameter of the combined fibers. We developed a reaction-diffusion model which focuses on the control of collagen synthesis by different isoforms of the polypeptide transforming growth factor-β (TGFβ). We used the model to investigate the current controversy as to whether the fibroblasts migrate into the wound from the surrounding unwounded dermis or from the underlying subcutaneous tissue. Numerical simulations of a spatially independent, temporal model led to a value of the collagen ratio consistent with that of healthy tissue for the fetus, but corresponding to scarring in the adult. We investigated the effect of topical application of TGFβ and show that addition of isoform 3 reduces scar tissue formation, in agreement with the experiment. However, numerical solutions of the reaction-diffusion system do not exhibit this sensitivity to growth factor application. Mathematically, this corresponds to the observation that behind healing wavefront solutions, a particular healed state is always selected independent of transients, even though there is a continuum of possible positive steady states. We explain this phenomenon using a caricature system of equations, which reflects the key qualitative features of the full model but has a much simpler mathematical form. Biologically, our results suggest that the migration into a wound of fibroblasts and TGFβ from the surrounding dermis alone cannot account for the essential features of the healing process, and that fibroblasts entering from the underlying subcutaneous tissue are crucial to the healing process.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1125-1144 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Oscillations in cytosolic Ca2+ concentrations in living cells are often a manifestation of propagating waves of Ca2+. Numerical simulations with a realistic model of inositol 1, 4, 5-trisphosphate (IP3)-induced Ca2+ wave trains lead to wave speeds that increase linearly at long times when (a) IP3 levels are in the range for Ca2+ oscillations, (b) a gradient of phase is established by either an initial ramp or pulse of IP3, and (c) IP3 concentrations asymptotically become uniform. We explore this phenomenon with analytical and numerical methods using a simple two-variable reduction of the De Young-Keizer model of the IP3 receptor that includes the influence of Ca2+ buffers. For concentrations of IP3 in the oscillatory regime, numerical solution of the resulting reaction diffusion equations produces nonlinear wave trains that shows the same asymptotic growth of wave speed. Due to buffering, diffusion of Ca2+ is quite slow and, as previously noted, these waves occur without appreciable bulk movement of Ca2+. Thus, following Neu and Murray, we explore the behavior of these waves using an asymptotic expansion based on the small size of the buffered diffusion constant for Ca2+. We find that the gradient in phase of the wave obeys Burgers' equation asymptotically in time. This result is used to explain the linear increase of the wave speed observed in the simulations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 59 (1997), S. 1183-1189 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The robustness of patterning events in development is a key feature that must be accounted for in proposed models of these events. When considering explicitly cellular systems, robustness can be exhibited at different levels of organization. Consideration of two widespread patterning mechanisms suggests that robustness at the level of cell communities can result from variable development at the level of individual cells; models of these mechanisms show how interactions between participating cells guarantee community-level robustness. Cooperative interactions enhance homogeneity within communities of like cells and the sharpness of boundaries between communities of distinct cells, while competitive interactions amplify small inhomogeneities within communities of initially equivalent cells, resulting in fine-grained patterns of cell specialization.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 1-26 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Many models have been proposed for spatial pattern formation in embryology and analyzed for the standard case of zero-flux boundary conditions. However, relatively little attention has been paid to the role of boundary conditions on the form of the final pattern. Here we investigate, numerically, the effect of nonstandard boundary conditions on a model pattern generator, which we choose to be of a cell-chemotactic type. We specifically focus on the role of boundary conditions and the effects of scale and aspect ratio, and study the spatiotemporal dynamics of pattern formation. We illustrate the properties of the model by application to the spatiotemporal sequence of skeletal development.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 79-100 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A model, based on the principles of continuum mechanics, is presented for the analysis of cell-velocity fields within wool follicles. The model requires specification of three follicle characteristics in the form of spatially varying fields: viscosity, cell density and cell production rate. The viscosity is introduced as an attempt to model both complex intercellular interactions and individual cell deformation as the cells move. It is demonstrated that the distribution of cell production is more important than axial variation in viscosity in determining the overall flow pattern.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 131-150 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A microbial trichome extracts nutrients from its immediate surroundings. It may also oxidize electron donors, reduce electron acceptors, and exude the ‘waste’ products of endogenous redox metabolism. Finally, it may effect light harvesting. These exchange fluxes are summed up in a generic model, which covers photoautotrophs as well as chemoheterotrophs. The focus is on endogenous metabolism and the cellular homeostasis of both reducing and phosphorylating equivalents. A novel result is the formulation of four ‘rules’, akin to the Pasteur effect, which govern the compatibility of endogenous metabolism with various assimilatory processes.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 49-65 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In this paper we present a deterministic, discrete-time model for a two-patch predator-prey metapopulation. We study optimal harvesting for the metapopulation using dynamic programming. Some rules are established as generalizations of rules for a single-species metapopulation harvesting theory. We also establish rules to harvest relatively more (or less) vulnerable prey subpopulations and more (or less) efficient predator subpopulations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 51
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 919-935 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract To analyze signals measured from human blood flow in the time-frequency domain, we used the wavelet transform which gives good time resolution for high-frequency components and good frequency resolution for low-frequency components. Five characteristic frequency peaks, corresponding to five almost periodic rhythmic activities, were found on the time scale of minutes. These oscillations were characterized by time and spatial invariant measures. The potential of this approach in studying the blood-flow dynamics was illustrated by revealing differences between the groups of control subjects and athletes.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 52
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 997-998 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 1167-1200 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The interaction of a pair of weakly coupled biological bursters is examined. Bursting refers to oscillations in which an observable slowly alternates between phases of relative quiescence and rapid oscillatory behavior. The motivation for this work is to understand the role of electrical coupling in promoting the synchronization of bursting electrical activity (BEA) observed in the β-cells of the islet of Langerhans, which secrete insulin in response to glucose. By studying the coupled fast subsystem of a model of BEA, we focus on the interaction that occurs during the rapid oscillatory phase. Coupling is weak, diffusive and non-scalar. In addition, non-identical oscillators are permitted. Using perturbation methods with the assumption that the uncoupled oscillators are near a Hopf bifurcation, a reduced system of equations is obtained. A detailed bifurcation study of this reduced system reveals a variety of patterns but suggests that asymmetrically phase-locked solutions are the most typical. Finally, the results are applied to the unreduced full bursting system and used to predict the burst pattern for a pair of cells with a given coupling strength and degree of heterogeneity.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 1017-1037 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Hemodynamic forces affect endothelial cell morphology and function. In particular, circumferential cyclic stretch of blood vessels, due to pressure changes during the cardiac cycle, is known to affect the endothelial cell shape, mediating the alignment of the cells in the direction perpendicular to stretch. This change in cell shape proceeds a drastic reorganization at the internal level. The cellular scaffolding, mainly composed of actin filaments, reorganize in the direction which later becomes the cell’s long axis. How this external mechanical stimulus is ’sensed’ and transduced into the cell is still unknown. Here, we develop a mathematical model depicting the dynamics of actin filaments, and the influence of the cyclic stretch of the substratum based on the experimental evidence that external stimuli may be transduced inside the cell via transmembrane proteins which are coupled with actin filaments on the cytoplasmic side. Based on this view, we investigate two approaches describing the formulation of the transduction mechanisms involving the coupling between filaments and the membrane proteins. As a result, we find that the mechanical stimulus could cause the experimentally observed reorganization of the entire cytoskeleton simply by altering the dynamics of the filaments connected with the integral membrane proteins, as described in our model. Comparison of our results with previous studies of cytoskeletal dynamics reveals that the cytoskeleton, which, in the absence of the effect of stretch would maintain its isotropic distribution, slowly aligns with the precise direction set by the external stimulus. It is found that even a feeble stimulus, coupled with a strong internal dynamics, is sufficient to align actin filaments perpendicular to the direction of stretch.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 60 (1998), S. 1149-1166 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We study a general predator—prey system in a spatially heterogeneous environment. The predation process, which occurs on a behavioural time-scale, is much faster than the other processes (reproduction, natural mortality and migrations) occurring on the population dynamics time-scale. We show that, taking account of this difference in time-scales, and assuming that the prey have a refuge, the dynamics of the system on a slow time-scale become donor-controlled. Even though predators may control the prey density locally and on a behavioural fast time-scale, nevertheless, both globally and on a slow time-scale, the prey dynamics are independent of predator density: the presence of predators generates a constant prey mortality. In other words, in heterogeneous environments, the prey population dynamics depend in a switch-like manner on the presence or absence of predators, not on their actual density.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 56
    Digitale Medien
    Digitale Medien
    Springer
    The journal of Fourier analysis and applications 4 (1998), S. 283-297 
    ISSN: 1531-5851
    Schlagwort(e): Primary 42B25 ; 30D10 ; Secondary 26A16 ; 46B45 ; 47B10 ; 47B35 ; Mean oscillation ; Paley-Wiener space ; Besov spaces ; wavelets ; commutators ; Hankel operators ; Schatten-von Neumann ideals
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The oscillatory behavior of functions with compactly supported Fourier transform is characterized in a quantified way using various function spaces. In particular, the results in this article show that the oscillations of a function at large scale are comparable to the oscillations of its samples on an appropriate discrete set of points. Several open questions about spaces of sequences are answered and applications in the study of commutator operators on the Paley-Wiener space are shown.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 57
    Digitale Medien
    Digitale Medien
    Springer
    The journal of Fourier analysis and applications 4 (1998), S. 329-340 
    ISSN: 1531-5851
    Schlagwort(e): 42C15 ; 46E35 ; Wavelets ; function spaces ; fractals
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Wavelets on self-similar fractals are introduced. It is shown that for certain totally disconnected fractals, function spaces may be characterized by means of the magnitude of the wavelet coefficients of the functions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 58
    Digitale Medien
    Digitale Medien
    Springer
    The journal of Fourier analysis and applications 4 (1998), S. 357-375 
    ISSN: 1531-5851
    Schlagwort(e): 42C15 ; 94A12 ; wavelets ; interpolation ; orthogonal expansions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Gibbs' phenomenon occurs for most orthogonal wavelet expansions. It is also shown to occur with many wavelet interpolating series, and a characterization is given. By introducing modifications in such a series, it can be avoided. However, some series that exhibit Gibbs' phenomenon for orthogonal series do not for the associated sampling series.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 59
    Digitale Medien
    Digitale Medien
    Springer
    Transformation groups 2 (1997), S. 225-267 
    ISSN: 1531-586X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We study Edidin and Graham's equivariant Chow groups in the case of torus actions. Our main results are: (i) a presentation of equivariant Chow groups in terms of invariant cycles, which shows how to recover usual Chow groups from equivariant ones; (ii) a precise form of the localization theorem for torus actions on projective, nonsingular varieties; (iii) a construction of equivariant multiplicities, as functionals on equivariant Chow groups; (iv) a construction of the action of operators of divided differences on theT-equivariant Chow group of any scheme with an action of a reductive group with maximal torusT. We apply these results to intersection theory on varieties with group actions, especially to Schubert calculus and its generalizations. In particular, we obtain a presentation of the Chow ring of any smooth, projective spherical variety.
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  • 60
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    Digitale Medien
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    Transformation groups 2 (1997), S. 375-390 
    ISSN: 1531-586X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper we explicitly determine the virtual representations of the finite Weyl subgroups of the affine Weyl group on the cohomology of the space of affine flags containing a family of elementsn t in an affine Lie algebra. We also compute the Euler characteristic of the space of partial flags containingn t and give a connection with hyperplane arrangements.
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  • 61
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    Transformation groups 2 (1997), S. 351-374 
    ISSN: 1531-586X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract LetG be a connected, simply-connected, real semisimple Lie group andK a maximal compactly embedded subgroup ofG such thatD=G/K is a hermitian symmetric space. Consider the principal fiber bundleM=G/K s →G/K, whereK s is the semisimple part ofK=K s ·Z K 0 andZ K 0 is the connected center ofK. The natural action ofG onM extends to an action ofG 1=G×Z K 0 . We prove as the main result thatM is weakly symmetric with respect toG 1 and complex conjugation. In the case whereD is an irreducible classical bounded symmetric domain andG is a classical matrix Lie group under a suitable quotient, we provide an explicit construction ofM=D×S 1 and determine a one-parameter family of Riemannian metrics Ω onM invariant underG 1. Furthermore,M is irreducible with respect to Ω. As a result, this provides new examples of weakly symmetric spaces that are nonsymmetric, including those already discovered by Selberg (cf. [M]) for the symplectic case and Berndt and Vanhecke [BV1] for the rank-one case.
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  • 62
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    Circuits, systems and signal processing 16 (1997), S. 27-40 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The Wigner bispectrum of multicomponent signals is studied, and its modified and reduced forms are introduced. A generalization of the presented forms to the Wigner higher-order spectra (WHOS), in the case of multicomponent signals, is provided. From our previous work it is known that cross terms removal (reduction) is possible for odd-order spectra with equal numbers of conjugated and nonconjugated terms. Here, we extend the analysis to even-order spectra. The theory is illustrated by examples.
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  • 63
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    Circuits, systems and signal processing 16 (1997), S. 83-89 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We describe methods to establish identifiability and information-regularity of parameters in normal distributions. Parameters are considered identifiable when they are determined uniquely by the probability distribution and they are information-regular when their Fisher information matrix is full rank. In normal distributions, information-regularity implies local identifiability, but the converse is not always true. Using the theory of holomorphic mappings, we show when the converse is true, allowing information-regularity to be established without having to explicitly compute the information matrix. Some examples are given.
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  • 64
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    Circuits, systems and signal processing 16 (1997), S. 141-163 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The extendibility of estimated correlation bisequences from an available sampled data array is described in terms of the generating functions of associated block Toeplitz with Toeplitz block (BTTB) matrices. The periodogram-based correlation bisequences are shown to be extendible. It is shown that the method of resultants and subresultants is convenient for generating the nonlinear constraints in the optimization problem which is solved iteratively for power spectrum estimation. A nontrivial example illustrates the concepts developed.
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  • 65
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    Circuits, systems and signal processing 16 (1997), S. 217-239 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A multiresolutional approach is presented for effectively recognizing three-dimensional (3D) objects. The approach is both pose and scale invariant. A multiresolutional model base is constructed, and multiscale edges of the object are detected using the wavelet transform. The minimum alignment between model base and object is realized by the linear mapping scheme.
    Materialart: Digitale Medien
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  • 66
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    Circuits, systems and signal processing 16 (1997), S. 59-67 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The potential for data compression in using fractal interpolation functions (FIFs) is realized by the construction of a set of multirate filters. The filter tap weights are determined by optimizing the energy contents of a preselected set of frequency bands. This filter bank implementation of the FIF is successfully used to compress data simulated in a tracking environment.
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  • 67
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    Circuits, systems and signal processing 16 (1997), S. 91-106 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A first-order autoregressive filter is altered by changing the constant gain to two or more gains that cyclically alternate in time. The advantages of this system are shown, and the relation to linear autoregressive moving average difference equations of higher order is derived.
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  • 68
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    Circuits, systems and signal processing 16 (1997), S. 165-195 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper refers to the fast implementation of the positional forward acceleration of the end effector of revolute robotic arms with spherical wrists, using the distributed arithmetic technique. The acceleration of the end effector is calculated by a cascade configuration of two pipelined arrays that calculate the Jacobian matrix and its time derivative, as well as the centrifugal-Coriolis and linear accelerations. These partial accelerations are then added in the adder tree. The building blocks of the arrays are the distributed arithmetic-based circuits that implement the matrix-vector multiplications involved in the calculations. The digit-serial configuration of the proposed implementation of the positional forward acceleration of the end effector is described. The serial and the parallel configurations may result as special cases of the digit-serial configuration. The proposed distributed arithmetic (DA) implementation of the positional forward acceleration may be applied, after appropriate modifications, to the general case of robots having either revolute or prismatic joints, with any type of wrist.
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  • 69
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    Circuits, systems and signal processing 16 (1997), S. 241-245 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper addresses the calculation of the extrema of the sin x/x function. First the Newton-Raphson method is used, which allows us to obtain the extrema locations very fast through the use of a recursion formula. Then a second approach is proposed, which gives the extrema locations and the extrema amplitudes in the form of series expansions. Simple, accurate algebraic expressions are derived.
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  • 70
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    Circuits, systems and signal processing 16 (1997), S. 307-324 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We give some existence results for a resistive network in which the components are neither voltage nor current controlled; that is, they are merely unicursal. In fact we allow coupling. Degree arguments give existence and bounds. We study several ways of avoiding the requirement of eventual passivity. No-gain and passive multiterminal elements are included. The results are extended to infinite networks.
    Materialart: Digitale Medien
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  • 71
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    Circuits, systems and signal processing 16 (1997), S. 375-386 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Random sampling is one of the methods that can overcome the Nyquist limit when evaluating a frequency spectrum of a signal. However, the computational complexity becomesN 2 as the FFT cannot be used. A new approach, called hybrid additive random sampling, is proposed. This new scheme is devised by concatenating random sampling sequences in such a way that symmetry is created in the transform kernel for reducing the computational effort while the anti-alias property is maintained. A savings of the least 75% in computation is achieved. The sampling scheme is also found to be suitable for parallel implementation. In this paper, the algorithms for generating the sampling sequence and evaluating the spectrum are described in detail. The performances of the scheme in terms of noise, accuracy, etc., are compared with genuine random sampling and another approach proposed previously. The advantages and limitations are included.
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  • 72
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    Circuits, systems and signal processing 17 (1998), S. 85-102 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, we present a hybrid space-time-filtered Viterbi receiver using multiple antennas for co-channel interference (CCI) reduction and intersymbol interference (ISI) equalization in a slow Rayleigh fading channel. In this approach, a space-time filter is first applied at the antenna outputs to maximize the signal-to-interference-plus-noise ratio (SINR), and the scalar output is then sent to a Viterbi equalizer. We propose a closed-form solution to jointly determine the weight vector for the space-time filter and the channel vector for the Viterbi equalizer. We also examine the need for a whitening filter prior to the Viterbi equalizer and show that it only marginally improves the performance. Simulation results are provided to validate our approach and to compare the performance of our receiver with that of different existing receivers.
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  • 73
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    Circuits, systems and signal processing 17 (1998), S. i 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 74
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    Circuits, systems and signal processing 17 (1998), S. 123-136 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Prosthetic heart valves have been responsible for extending the life spans and improving the quality of life of many people with serious heart conditions. Even though the heart valves are extremely reliable, eventually they are susceptible to the long-term fatigue and structural failure effects expected for mechanical devices operating over long periods of time. In [2] a classification procedure was developed using spectral features obtained from acoustic signals to determine the condition of the prosthetic heart valve. Although this classification procedure has produced very encouraging results, this method still lacks a fundamental physical description of the sounds produced by the valve during normal operation. In order to obtain a better understanding of the valve acoustic response, we have performed a set of anechoic tests. In this paper, we describe the anechoic experiment and also present limited transient response results. This transient information will eventually be used to identify and improve the features used to classify the valve condition.
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  • 75
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    Circuits, systems and signal processing 17 (1998), S. 195-218 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this two-part study we present a new design methodology for neural classifiers. The design procedure utilizes a multiclass vector quantization (MVQ) algorithm for information extraction from the training set. The extracted information suffices to specify the hidden layer in a canonical neural network architecture. The extracted information also leads to the specification of neuron inhibition rules and subsequently the design of the hidden layer-to-output map. In Part I of the study we focus attention on the MVQ algorithm and how it is used to extract information from a training set. The extracted information is referred to as thecodebook. The codebook is used to directly specify the hidden layer. This specification can take the form of a perceptron layer, a radial basis layer, or a heterogeneous layer involving a mixture of neuron types. These and otherh-layer specifications are determined directly from the same extracted information. The MVQ codebook also suffices to scale the activation function of each neuron. In Part II we consider the nonsimplistic hidden layer-to-output map design. We note that the MVQ algorithm, as it extracts information, decomposes the design set into disjoint neighborhoods. For each neighborhood we identify subsets of the hidden layer neurons, which are significant sensors for the neighborhood. For each such subset we construct an output map. Inhibition rules are established to ensure that the proper output map is activated. In benchmark simulations the overall design exhibits excellent performance, to the extent that we are hard pressed to identify bounds on performance, if any.
    Materialart: Digitale Medien
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  • 76
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    Circuits, systems and signal processing 17 (1998), S. 361-389 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A transform domain image tagging orwatermarking method that survives image cropping (and, hence, is “holographic”) was proposed at Bell Labs in September 1994. This report analyzed in detail the various properties of this method and introduces an optimal procedure for watermark recovery.
    Materialart: Digitale Medien
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  • 77
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    Circuits, systems and signal processing 17 (1998), S. 483-493 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract An algorithm for the exact computation of the frequency responses of linear interval systems is obtained. For the computation a sectoring stage is added to an elimination algorithm to eliminate interior curves. It is shown that the intersection of a ray and the frequency response set is an empty set or a line segment whose endpoints are extrema of the functions defined. Required mathematical analysis tools for the development of the sectoring algorithm and an illustrative example are provided.
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  • 78
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    Circuits, systems and signal processing 17 (1998), S. 559-574 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The geometric theory of the domain of an ordered pair (F, G) of matrices or the geometry associated with matrix pencils provides a unifying framework for the study of algebraic, dynamic and feedback properties of linear singular systems. The key concepts and tools of the geometry are the notions of the (F, G)-, (G, F)-invariance and a set of subspace sequences. In this paper, an alternative characterization of these sequences is given based on the properties of the partitioned null spaces of appropriate sequences of Toeplitz matrices defined by the (F, G) pair. The results provide a simple procedure for the computation of the limit spaces of these sequences and clearly cover corresponding problems of the singular, implicit systems theory.
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  • 79
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    Circuits, systems and signal processing 17 (1998), S. 667-682 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper presents a new concept of narrowband and broadband active noise compression (ANCom) systems which improves the conventional active noise equalization (ANE) technique to meet some practical requirements. By using a variable equalization coefficient, the narrowband ANCom system can automatically switch among the four different operating modes of narrowband ANE, according to the primary noise power. As a result, it can “compress” the narrowband noise into a desired power range when the primary noise power varies drastically. Compared to a conventional broadband ANE system, the novel broadband ANCom system not only has the ability to shape the residual noise power spectrum, but can also compress the residual noise power into a predetermined dynamic range as the narrowband AN-Com does. Theoretical analyses are conducted for both the narrowband ANCom and broadband ANCom systems. Simulation results show that the proposed algorithms work well in both static and dynamic situations.
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  • 80
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    Circuits, systems and signal processing 17 (1998), S. 703-708 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The cornerstone of the theory of discrete-space single-input single-output linear systems is the idea that every such system has an input-output mapH that can be represented by a convolution or the familiar generalization of a convolution. This thinking involves an oversight, which, for the case of bounded inputs mapped continuously into bounded outputs, was recently corrected by adding an additional term to the representation. Here we give a more general result that addresses an important larger family of inputs.
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  • 81
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    Circuits, systems and signal processing 17 (1998), S. 737-755 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper the problem of robust stabilizing a linear, time-invariant singular system is studied. The characterization is given in terms ofH ∞-bounded perturbations to the numerator and denominator factors of its normalized left coprime factorization. An optimal stability margin is provided in terms of the definition of the Hankel norm of a singular system. The Hankel norm is computed using two generalized Lyapunov equations.
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  • 82
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    Circuits, systems and signal processing 16 (1997), S. 41-58 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper presents a comparison between the traditional image processing method and the area vector concept as well as the new technique of artificial neural networks. Freeman chain coding is considered in the study, and the principle of segmentation may be based and implemented for further investigations resulting from the proposed work. The pattern recognition concept is analyzed and defined through the sigmoid function and the determination of the threshold of a gray image for an object. The block schemes for the given protocols are summarized in a single scheme for illustration and comparison purposes. The synthetic pictures are generated and investigated regarding the dependence of computer vision on the contents of the artificial neural network. The normalization technique is included to eliminate noise and zooming problems. The minimum computational time for image processing with the generated pictures is also determined. The rate of deflection in the computational time is recommended for sensing the minimum computational time according to the variation of the number of hidden units in the hidden layer. A three-layer neural network has been used. The study of gray binary imaging for color pictures is illustrated to save computational time and effort.
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  • 83
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    Circuits, systems and signal processing 16 (1997), S. 247-270 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Of concern is an environment made up of signals and systems tightly confined both in time and frequency. Such an environment is often encountered in transmission line circuits, radar, sonar, and optical circuits, and when the principal signals are well-defined sharp pulses. It will be seen that once this environment is achieved, the signals and systems possess some attractive properties. A conventional system may preserve the symmetry of a propagating signal or change its symmetry from even to odd or from odd to even. Another system may be used to predict the arrival of an incoming pulse with a high degree of accuracy. Electrical networks may also be associated with these properties. Approximation problems, existence theorems, and realization schemes will be addressed and developed.
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  • 84
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    Circuits, systems and signal processing 16 (1997), S. 325-347 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper develops a new digitally redesigned pulse-amplitude modulated (PAM) controller for a continuous-time input time-delay/nondelay system with nonsynchronous sampling. The concept of the law of the mean from the input integral calculus is utilized for the development of the equivalent digital predictor controllers from the available analog predictor controllers. As a result, the digitally controlled states closely match the original continuous-time states. To implement the developed discrete-time state-feedback PAM controller, this paper also develops an ideal discrete-time state using nonsynchronously sampled input-output data of the continuous-time input delay/nondelay system without establishing a dynamic observer.
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  • 85
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    Circuits, systems and signal processing 16 (1997), S. 429-438 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The model-matching problem for systems described by external models is considered in frameworks of both external and input-output equivalence. Necessary conditions for the solvability of the problem are produced, and it is shown that in certain cases these conditions are also sufficient. In the case where necessary and sufficient conditions exist, the solutions of the problem are obtained in a constructive way and a parametrization of solutions is given.
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  • 86
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    Circuits, systems and signal processing 16 (1997), S. 523-536 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper addresses the invariance property of Gaussian signals, originally derived by Bussgang, which characterizes the input/output moment relation of a hybrid nonlinear moment (HNM) estimator based on a zero-memory nonlinearity (ZMN) g(y). Some re-derivations of this property are reviewed, and an original, direct, and simple proof is presented (Appendix 1). The paper then derives a new interpretation of this property (Theorem 1) that shows a moment-sense equivalence between g(y) and a linear mappingh 1(y) whose coefficients a0 and a1 are completely characterized in terms ofg(y) and are shown to be optimal in a mean square error (MSE) sense. A direct and very interesting byproduct of this interpretation is a simple linear relationship between the input and output of the HNM estimator involved. The property is then generalized (Theorem 2) to signals other than Gaussian, resulting in an infinite cumulant series expansion of the HNM estimator output, whose coefficients are all characterized in terms ofg(y). Applications of Theorem 1 to some ZMNs commonly used in signal processing and control theory are presented that clearly illustrate the power and elegance of the invariance property. Finally, some conclusions are given.
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  • 87
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    Circuits, systems and signal processing 16 (1997), S. 547-557 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper the connection between ‘mass’M, ‘resistance’ϱ and ‘commute time’θ for random walks on graphs is further explored, and the relationθ=2M ·ϱ is proved. An extension of the result is made to multigraphs, which are an extension of the graph concept where a black box is treated like an edge.
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  • 88
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    Circuits, systems and signal processing 16 (1997), S. 625-647 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Let {S(A):A ∈A}, whereA is a subset of an infinite-dimensional normed linear spaceL, be a class of general nonlinear input-output systems that are governed by operator equations relating the input, state, and output, all of which are in extended spaces. IfQ is a given operator from a specified set ¯D i, of inputs into the space of outputs ¯H 0, the problem we consider is to find, for a given ɛ〉0, a “parameter”A ε∈A such that the transmission operatorR(A ε) ofS(A ε) furnishes a nearly best (or ɛ-best) approximation toQ from allR(A),A ∈A. Here the “distance” betweenQ andR(A) is defined as the supremum of distances betweenQz andR(A)z taken over allz ∈ ¯D i. In Theorems 2 through 5 we show that ifS(A) is “normal” (Definition 2),A satisfies some mild requirement andL contains a fundamental sequence, then establishingA ε∈A reduces to minimizing a certain continuous functional on a compact subset ofR n, and thus can be carried out by conventional methods. The applications of results are illustrated by the example of a model-matching problem for a nonlinear system, and of optimal tracking.
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  • 89
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    Circuits, systems and signal processing 16 (1997), S. 649-654 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract It is shown that the elementsG of a large class of input-output maps can be uniformly approximated arbitrarily well using a certain structure if and only ifG is continuous. For the case considered the system inputs and outputs are defined on a discrete set {0, 1,...,a 1}×...{0, 1,...,a m }, in which a1,...,a m are positive integers. Our approximating structure involves certain functions that can be chosen in different ways. For the special case in which these functions are taken to be certain polynomial functions, the input-output map of our structure is a generalized discrete Volterra series. Our results provide an analytical basis for the use of such series.
    Materialart: Digitale Medien
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  • 90
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 16 (1997), S. 663-701 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, the stability robustness of deterministic state feedback discretetime linear quadratic (LQ) optimal regulators for the performance index with cross-product terms is analyzed. Guaranteed stability margins for such a type of LQ optimal regulator are suggested for the first time. These stability margins are obtained on the basis of a modified return difference equality and are expressed directly in terms of the elementary cost and system matrices. Sufficient conditions to guarantee the required stability margins are presented. Finally, the connection between the suggested stability margins and the selection of weighting state, input, and cross-product matrices is investigated, and useful guidelines for choosing proper weighting matrices are presented.
    Materialart: Digitale Medien
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  • 91
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 1-27 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A novel computationally efficient realization of sharp linear-phase finite impulse response (FIR) bandstop filters is proposed. The synthesis scheme for the bandstop filters is derived from variations of the frequency-response-masking technique. Five realization structures are presented in this paper for the synthesis of five different classes of bandstop filters. Approximate expressions for the optimal value of the impulse response up-sampling ratio (M) and the corresponding number of multipliers are derived.
    Materialart: Digitale Medien
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  • 92
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 29-49 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Estimating the covariance sequence of a wide-sense stationary process is of fundamental importance in digital signal processing (DSP). A new method, which makes use of Fourier inversion of the Capon spectral estimates and is referred to as theCapon method, is presented in this paper. It is shown that the Capon power spectral density (PSD) estimator yields an equivalent autoregressive (AR) or autoregressive moving-average (ARMA) process; hence, theexact covariance sequence corresponsing to the Capon spectrum can be computed in a rather convenient way. Also, without much accuracy loss, the computation can be significantly reduced via an approximate Capon method that utilizes the fast Fourier transform (FFT). Using a variety of ARMA signals, we show that Capon covariance estimates are generally better than standard sample covariance estimates and can be used to improve performances in DSP applications that are critically dependent on the accuracy of the covariance sequence estimates.
    Materialart: Digitale Medien
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  • 93
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 51-68 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Results in the study of signal processing based on the use of parameter structural modeling (PSM) are presented. First, we introduce a special form of time-series modeling based on signal-dependent building blocks. Such modeling is used in the design of a nestedform transversal structure, known as a composite filter, based on a shift-invariant finite impulse resonse (FIR) as well as infinite impulse response (IIR) building blocks. The newly proposed composite PSM model (CPSM) possesses a unique feature, namely, its ability to suppress one signal of a given structure, while at the same time being ideally transparent to another one. The intrinsic property of this proposed CPSM is its enhanced insensitivity with respect to noise as well as its ability to fast track, in contrast to the commonly used linear line-enhancer based on conventional autoregressive moving average (ARMA), thus leading to a more practically sound processing of short-duration signals. It is shown that the proposed time-series modeling based on CPSM can be effectively applied towards the separation of superimposed signals of heavily overlapping spectra. Next, the parameter-invariant nonlinear structural signal representation based on shift-invariant CPSM is presented. The use of this model in the design of annihilation operators (AO) is described, and composite parameter-free structural modeling (CPFSM) is developed. Based on this model, two canonical forms of the parameter-invariant null filters (PINF) are presented, and their use in the suppression of a given class of signals, independently of the values of theira priori unknown parameters, is illustrated. The paper also presents some simulation examples illustrating the application of the proposed CPSM and CPFSM in solving problems of detection and parameter estimation in the presence of highly non-Gaussian, mainly signal-like interferences.
    Materialart: Digitale Medien
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  • 94
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 69-83 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This work is motivated by the need forFaithful digital simulation of cellular neural networks (CNNs) that maintains most of their qualitative properties of stability and convergence. An interconnection of nonlinear digital filters mimicking behaviors of the analog CNNs is proposed, and the main properties are studied in detail. The discrete model obtained is proven to have the same convergence properties as the original analog network. The key to this development is the use of anAppropriate discretization scheme. Our discrete approximation to the nonlinear state-space representation of cellular neural networks is such that the Lyapunov function used to show convergence in analog cellular neural networks is still a Lyapunov function (when appropriately discretized) for our nonlinear digital filter network. This is in contrast to other digital simulations of CNNs, which have not been proven to preserve the convergence properties. The network of nonlinear digital filters so introduced thus adds another item to the catalog of digital filters obtained viaappropriate discretization of analog circuits, e.g., wave digital filters, orthogonal filters, and certain other of their more recently studied nonlinear counterparts.
    Materialart: Digitale Medien
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  • 95
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 117-122 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, the problem of blind channel identification and equalization is reviewed, and some recent results are presented.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 137-164 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper presents in summarizing form a description of halfband filters and the related symmetrical Hilbert transformers. It starts with the two complemetary relations by which halfband filters are defined and the consequences for their impulse responses. The idealized versions of the frequency responses of halfband lowpasses and Hilbert transformers are introduced, and the related tolerance schemes that realized systems must satisfy are described. Using their frequency responses, the transformation of one filter type into the other is presented in general form. The design of finite impulse response (FIR)-halfband filters and their relation to corresponding Hilbert transformers are recalled, using maximally flat and Chebyshev approximations as examples. It is shown that the relation between both types of systems can be used for the infinite impulse response (IIR) case as well. The design of IIR-halfband filters is presented for systems with approximately linear phase and for those with minimum phase again for maximally flat and Chebyshev approximations. The design methods are partly new. The general procedure for the transformation into Hilbert transformers yields noncausal solutions, one of which is already known from the literature. By modifying this operation, phase-splitting systems are obtained, one of them related to corresponding continuous ones, discussed in papers published around 1950. Another system with approximately linear phase corresponds to a paper presented in 1987. Finally, the coupled form of these phase splitting allpasses is found to be a Hilbert transformer with precise phase difference, but with deviations of the magnitudes of the frequency responses.
    Materialart: Digitale Medien
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  • 97
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 165-193 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The matched field processing (MFP) localization performance of very low frequency (VLF) arrays operated in the deep ocean basins appears to be limited more by uncertainty in the sound velocity profile (SVP) than by low signal-to-noise ratio (SNR). We present a new robust variation of MFP designed to be less sensitive to velocity error in weakly inhomogeneous environments. We analyze the computational requirements of this and other MFP algorithms. When either the search volume is large of the acoustic array is large, computational efficiency is an issue. We present an efficient MFP implementation for the conventional MFP algorithm and our robust algorithm. We show that parallel implementation of these algorithms may allow real-time performance.
    Materialart: Digitale Medien
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  • 98
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 219-241 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract By applying results from homotopy theory, new conditions are obtained for the existence and uniqueness of an equilibrium for a class of continuous-time feedback neural networks which contains the Hopfield model as a special case. Next, new criteria are established for the global asymptotic stability of the unique equilibrium of this class of neural networks by utilizing Lur'e-type Lyapunov functions and the stability theory for systems of differential inequalities. Several practical stability testing conditions are given. As a special case, criteria are derived for the global asymptotic stability of Hopfield neural networks. This is followed by a robustness analysis of the class of neural networks considered. The results obtained are then applied to an optimization problem.
    Materialart: Digitale Medien
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  • 99
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 271-287 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Functional artificial neural networks (FANNs) are artificial neural networks (ANNs) in which the synaptic weights are “functions” rather than numbers. Thus the signals in such networks are analog, and the action of a synapse on a signal passing through it takes place in the form of a scalar product inL 2 between the functional weight and the signal. In this paper, four classes of FANNs are introduced. They result from the solution of a nonparametric optimization problem in a generalized Fock space (GFS) of abstract Volterra series under interpolating or smoothing input-output training data constraints. Two of these classes of FANNs correspond to the interpolating case and are represented by what we call the (two-layer)optimal interpolating (OI) FANN and theoptimal multilayer neural interpolating (OMNI) FANN. The remaining two classes correspond to the smoothing case. We name their representations as the (two-layer)optimal smoothing (OS) FANN and theoptimal smoothing multilayer artificial neural (OSMAN) FANN. In addition to providing the background and the derivation of these FANNs, this paper presents a novel approach to their implementation. This approach does away with the computationally cumbersome use of functional weights. Instead, the effect of these weights is provided by linear time-invariant differential equation models of which those weights are impulse responses. These are implemented by a linear filter bank. This approach thus leads to simple and meaningful causal realizations of FANNs which we call Dynamical FANNs or simply D-FANNs.
    Materialart: Digitale Medien
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  • 100
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 17 (1998), S. 243-270 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, we study the problem of maximizing an objective function over the discrete set {−1, 1} n using a neural network. It is now known that a binary (two-state) Hopfield network can take, in the worst case, an exponential number of time steps to find even a local maximum of the objective function. In this paper, we carry this argument further by studying theradius of attraction of the global maxima of the objective function. If a binary neural network is used, in general there is no guarantee that a global maximum has a nonzero radius of attraction. In other words, even if the optimization process is started off with the neural network in an initial state that isadjacent to the global maximum, the resulting trajectory of the network may not converge to the nearby maximum, but may instead go off to another maximum. At the same time, another set of recent results shows that, if ananalog neural network is used to optimize the same objective function, thenevery local maximum of the objective function has a nontrivial domain of attraction, and conversely, the only equilibria that are attractive are the local maxima of the objective function. This raises the question as to whether analog neural networks offer some advantages over binary neural networks for optimizing the same objective function. As a motivation for this line of inquiry, we study the problem of decoding an algebraic block code using a neural network. It is shown that the binary neural network implementation has the undesirable property thatall the global maxima of the objective function have azero radius of attraction. In contrast, if an analog neural network is used to maximize exactly the same objective function, the region of attraction of each maximum contains not only the associated “orthant” of the state space, but also some points not in this orthant. In other words, the analog implementation exhibits the desired tolerance to transmission errors, whereas the binary neural network does not have this property. With this motivation, two open questions are posed that provide a program of research for studying the possible superiority of analog neural networks over binary neural networks.
    Materialart: Digitale Medien
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