Publication Date:
1994-05-27
Description:
Fifty-eight percent of hepatocellular carcinomas (HCCs) from Qidong, China, contain an AGG to AGT mutation at codon 249 of the p53 tumor suppressor gene, a mutation that is rarely seen in HCCs from Western countries. The population of Qidong is exposed to high levels of aflatoxin B1 (AFB1), a fungal toxin that has been shown to induce the same mutation in cultured human HCC cells. To investigate the role of AFB1 and of these p53 mutations in hepatocarcinogenesis, normal liver samples from the United States, Thailand, and Qidong (where AFB1 exposures are negligible, low and high, respectively) were examined for p53 mutations. The frequency of the AGG to AGT mutation at codon 249 paralleled the level of AFB1 exposure, which supports the hypothesis that this toxin has a causative--and probably early--role in hepatocarcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aguilar, F -- Harris, C C -- Sun, T -- Hollstein, M -- Cerutti, P -- New York, N.Y. -- Science. 1994 May 27;264(5163):1317-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Carcinogenesis, Swiss Institute for Experimental Cancer Research, Lausanne.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8191284" target="_blank"〉PubMed〈/a〉
Keywords:
Aflatoxin B1/*adverse effects
;
Carcinoma, Hepatocellular/chemically induced/*genetics
;
China
;
Codon/genetics
;
*Genes, p53
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Humans
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Liver/*chemistry
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Liver Neoplasms/chemically induced/*genetics
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*Point Mutation
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Thailand
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United States
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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