ALBERT

Description: We reconstructed the late Holocene relative sea-level (RSL) evolution of the ancient harbour of Naples, one of the largest coastal conurbations in the Mediterranean. We carried out multiproxy investigations, coupling archaeological evidence with biological indicators. Our data robustly constrain 2000 yr of non-monotonic changes in sea level, chiefly controlled by the complex volcano-tectonic processes that characterize the area. Between ∼200 BC and AD ∼0, a subsidence rate of more than ∼1.5 mm/yr enhanced the postglacial RSL rise, while negligible or moderate land uplift 〈 ∼0.5 mm/yr triggered a RSL stabilization during the Roman period (first five centuries AD). This stabilization was followed by a post-Roman enhancement of the sea-level rise when ground motion was negative, attested by a subsidence rate of ∼0.5 to ∼1 mm/yr. Our analysis seems to indicate very minor impacts of this nonmonotonic RSL evolution on the activities of the ancient harbour of Naples, which peaked from the third century BC to the second century AD. After this period, the progressive silting of the harbour basin made it impossible to safely navigate within the basin, leading to the progressive decline of the harbour.

Description: Published

Description: 284-298

Description: 1V. Storia eruttiva

Description: JCR Journal

Description: Late Quaternary landscapes of unglaciated Beringia were largely shaped by ice-wedge polygon tundra. Ice Complex (IC) strata preserve such ancient polygon formations. Here we report on the Yukagir IC from Bol’shoy Lyakhovsky Island in northeastern Siberia and suggest that new radioisotope disequilibria (230Th/U) dates of the Yukagir IC peat confirm its formation during the MIS 7a-c Interglacial. The preservation of the ice-rich Yukagir IC proves its resilience to Last Interglacial and lateglacial-Holocene warming. This study compares the Yukagir IC to IC strata of MIS 5, MIS 3 and MIS 2 ages exposed on Bol’shoy Lyakhovsky Island. Besides high intrasedimental ice content and syngenetic ice wedges intersecting silts, sandy silts, the Yukagir IC is characterized by high organic matter (OM) accumulation and low OM decomposition of a distinctive Drepanocladus moss-peat. The Yukagir IC pollen data reveals grassshrub-moss tundra indicating rather wet summer conditions similar to modern ones. The stable isotope composition of Yukagir IC wedge ice is similar to those of the MIS 5 and MIS 3 ICs pointing to similar atmospheric moisture generation and transport patterns in winter. Ice Complex data from glacial and interglacial periods provide insights into permafrost and climate dynamics since about 200 ka.

Description: The points where the horizontal component of the geomagnetic field vanishes are located in polar areas, far away from the geomagnetic (analytic) poles and the poles of rotation of the Earth and, differently from the geomagnetic poles, can be found experimentally with a magnetic survey to determine where the field is vertical. The experimental determination of the area where the total field is perfectly vertical, commonly known as dip pole, is not simple, due to the remoteness and harsh climatic conditions; another difficulty is related to the short term geomagnetic field variations, due to the interaction with the external solar wind, which causes the magnetospheric dynamics, particularly evident at high latitude, and as a consequence a displacement of the dip pole. Actually, the study of the dip pole displacements over short time scales can be an important tool for monitoring the magnetospheric dynamics at high latitude. In this study we present the updated location of the the dip poles, using data from the Swarm ESA’s constellation of satellites along their almost polar orbits. We also analyse the spatial shift of these areas during different seasons and interplanetary magnetic field orientations.

Description: Published

Description: 135-138

Description: 1A. Geomagnetismo e Paleomagnetismo

Description: N/A or not JCR

Description: We use low frequency geomagnetic field measurements at two Antarctic stations to statistically investigate the longitudinal location of the polar cusp. The two stations are both located in the polar cap at a geomagnetic latitude close to the cusp latitude; they are separated by one hour in magnetic local time. At each station the Pc5 power maximizes when the station approaches the cusp, i.e. around magnetic local noon. The comparison between the Pc5 power at the two stations allows to determine the longitudinal location of the cusp. Our analysis is conducted considering separately different orientation of the interplanetary magnetic field. The results, which indicate longitudinal shifts of the polar cusp depending on the selected conditions, are discussed in relation to previous studies of the polar cusp location based on polar magnetospheric satellite data.

Description: Published

Description: 139-141

Description: 1A. Geomagnetismo e Paleomagnetismo

Description: N/A or not JCR

Description: 〈p〉The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing–enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.〈/p〉

Description: 〈p〉Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.〈/p〉

Description: 〈p〉Voters may be unable to hold politicians to account if they lack basic information about their representatives’ performance. Civil society groups and international donors therefore advocate using voter information campaigns to improve democratic accountability. Yet, are these campaigns effective? Limited replication, measurement heterogeneity, and publication biases may undermine the reliability of published research. We implemented a new approach to cumulative learning, coordinating the design of seven randomized controlled trials to be fielded in six countries by independent research teams. Uncommon for multisite trials in the social sciences, we jointly preregistered a meta-analysis of results in advance of seeing the data. We find no evidence overall that typical, nonpartisan voter information campaigns shape voter behavior, although exploratory and subgroup analyses suggest conditions under which informational campaigns could be more effective. Such null estimated effects are too seldom published, yet they can be critical for scientific progress and cumulative, policy-relevant learning.〈/p〉

Description: 〈p〉The canonical view is that touch is signaled by fast-conducting, thickly myelinated afferents, whereas pain is signaled by slow-conducting, thinly myelinated ("fast" pain) or unmyelinated ("slow" pain) afferents. While other mammals have thickly myelinated afferents signaling pain (ultrafast nociceptors), these have not been demonstrated in humans. Here, we performed single-unit axonal recordings (microneurography) from cutaneous mechanoreceptive afferents in healthy participants. We identified A-fiber high-threshold mechanoreceptors (A-HTMRs) that were insensitive to gentle touch, encoded noxious skin indentations, and displayed conduction velocities similar to A-fiber low-threshold mechanoreceptors. Intraneural electrical stimulation of single ultrafast A-HTMRs evoked painful percepts. Testing in patients with selective deafferentation revealed impaired pain judgments to graded mechanical stimuli only when thickly myelinated fibers were absent. This function was preserved in patients with a loss-of-function mutation in mechanotransduction channel PIEZO2. These findings demonstrate that human mechanical pain does not require PIEZO2 and can be signaled by fast-conducting, thickly myelinated afferents.〈/p〉

Description: 〈p〉Mineralization is the most fundamental process in vertebrates. It is predominantly mediated by osteoblasts, which secrete mineral precursors, most likely through matrix vesicles (MVs). These vesicular structures are calcium and phosphate rich and contain organic material such as acidic proteins. However, it remains largely unknown how intracellular MVs are transported and secreted. Here, we use scanning electron-assisted dielectric microscopy and super-resolution microscopy for assessing live osteoblasts in mineralizing conditions at a nanolevel resolution. We found that the calcium-containing vesicles were multivesicular bodies containing MVs. They were transported via lysosome and secreted by exocytosis. Thus, we present proof that the lysosome transports amorphous calcium phosphate within mineralizing osteoblasts.〈/p〉

Description: 〈p〉Over 140 Mha of restoration commitments have been pledged across the global tropics, yet guidance is needed to identify those landscapes where implementation is likely to provide the greatest potential benefits and cost-effective outcomes. By overlaying seven recent, peer-reviewed spatial datasets as proxies for socioenvironmental benefits and feasibility of restoration, we identified restoration opportunities (areas with higher potential return of benefits and feasibility) in lowland tropical rainforest landscapes. We found restoration opportunities throughout the tropics. Areas scoring in the top 10% (i.e., restoration hotspots) are located largely within conservation hotspots (88%) and in countries committed to the Bonn Challenge (73%), a global effort to restore 350 Mha by 2030. However, restoration hotspots represented only a small portion (19.1%) of the Key Biodiversity Area network. Concentrating restoration investments in landscapes with high benefits and feasibility would maximize the potential to mitigate anthropogenic impacts and improve human well-being.〈/p〉

Description: 〈div data-abstract-type="normal"〉〈p〉The effectiveness of streak modes in controlling the oblique-type breakdown in a supersonic boundary-layer at Mach 2.0 is investigated using direct numerical simulations. Investigations in the literature have shown the effectiveness of streak modes in delaying the onset of transition dominated by two-dimensional waves, but in oblique breakdown, three-dimensional waves and a strong streak mode dominate the transition process. Paredes 〈span〉et al.〈/span〉 (〈span〉J. Fluid Mech.〈/span〉, vol. 831, 2017, pp. 524–553) discussed the possible stabilization of supersonic boundary layers by optimally growing streaks using parabolized stability equations. However, no study has as yet been reported regarding direct nonlinear control of oblique breakdown. This study deals with the effects of large-amplitude decaying streak modes generated by a blowing–suction strip at the wall to control full breakdown in a reference case. Modes with four to five times the fundamental wavenumber are found to be beneficial for controlling the transition. In the first region after the control-mode forcing, the beneficial mean-flow distortion (MFD), generated by inducing the control mode, is solely responsible for hampering the growth of the fundamental-mode. On the whole, the MFD and the three-dimensional part of the control contribute equally towards controlling the oblique breakdown. The results show significant suppression of transition, and substantial improvements have been observed in the levels of the skin-friction coefficient and wall-temperature in comparison to the uncontrolled case. Moreover, refreshing the control using an additional downstream control strip increases the gain. However, the forcing amplitude must be carefully chosen in order not to introduce a generalized inflection point in the spanwise averaged mean flow invoking enhanced disturbance growth.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉The problem of interaction between disturbances and shock waves was solved by a theoretical approach called linear interaction analysis in the mid-twentieth century. More recently, great progress has been made in analysing shock–turbulence interactions by direct numerical simulation. However, an unsolved theoretical problem remains: What happens when no acoustic waves are stimulated behind the shock wave? The concept of a damped wave is introduced, which is a type of excited plane wave. Based on this, the dispersion and amplitude relationships between any incident plane wave and resulting stimulated waves are constructed analytically, systematically and comprehensively. The physical essence of damped waves and the existence of critical angles are clarified. It is demonstrated that a damped wave is a complex number space solution to the acoustic dispersion relationship under certain conditions. It acts as a bridge connecting fast and slow acoustic waves at the position where the 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628130807083-0762:S0022112019004385:S0022112019004385_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 component of the group velocity is zero. There are two critical angles that can excite fast and slow acoustic waves, which determine the conditions that stimulate a damped wave. Our results show good agreement with theoretical and simulation results. The contribution of each excited wave to the transmission coefficient is evaluated, the distribution of the transmission coefficient is analysed and application to an engineering wedge model is performed.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉The onset of thermal convection in a rapidly rotating spherical shell is studied by linear stability analysis based on the fully compressible Navier–Stokes equations. Compressibility is quantified by the number of density scale heights 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, which measures the intensity of density stratification of the motionless, polytropic base state. The nearly adiabatic flow with polytropic index 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is considered, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the adiabatic polytropic index. By investigating the stability of the base state with respect to the disturbance of specified wavenumber, the instability process is found to be sensitive to the Prandtl number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. For large 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and small 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, the quasi-geostrophic columnar mode loses stability first; while for relatively small 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 a new quasi-geostrophic compressible mode is identified, which becomes unstable first under strong density stratification. The inertial mode can also occur first for relatively small 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and a certain intensity of density stratification in the parameter range considered. Although the Rayleigh numbers 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for the onsets of the quasi-geostrophic compressible mode and columnar mode are different by several orders of magnitude, we find that they follow very similar scaling laws with the Taylor number. The critical 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline11.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for convection onset is found to be always positive, in contrast with previous results based on the widely used anelastic model that convection can occur at negative 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline12.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. By evaluating the relative magnitude of the time derivative of density perturbation in the continuity equation, we show that the anelastic approximation in the present system cannot be applied in the small-〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline13.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and large-〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628092857401-0357:S0022112019004361:S0022112019004361_inline14.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 regime.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We study the breakup of confined fluid threads at low flow rates to understand instability mechanisms. To determine the critical conditions between the earlier quasi-stable necking stage and the later unstable collapse stage, simulations and experiments are designed to operate at an extremely low flow rate. The critical mean radii at the neck centres are identified by the stop-flow method for elementary microfluidic configurations. Two distinct origins of capillary instabilities are revealed for different confinement situations. One is the gradient of capillary pressure induced by the confinements of geometry and external flow, whereas the other is the competition between the capillary pressure and internal pressure determined by the confinements.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We report on a combined experimental and numerical study of convective heat transfer along ratchet surfaces in vertical natural convection (VC). Due to the asymmetry of the convection system caused by the asymmetric ratchet-like wall roughness, two distinct states exist, with markedly different orientations of the large-scale circulation roll (LSCR) and different heat transport efficiencies. Statistical analysis shows that the heat transport efficiency depends on the strength of the LSCR. When a large-scale wind flows along the ratchets in the direction of their smaller slopes, the convection roll is stronger and the heat transport is larger than the case in which the large-scale wind is directed towards the steeper slope side of the ratchets. Further analysis of the time-averaged temperature profiles indicates that the stronger LSCR in the former case triggers the formation of a secondary vortex inside the roughness cavity, which promotes fluid mixing and results in a higher heat transport efficiency. Remarkably, this result differs from classical Rayleigh–Bénard convection (RBC) with asymmetric ratchets (Jiang 〈span〉et al.〈/span〉, 〈span〉Phys. Rev. Lett.〈/span〉, vol. 120, 2018, 044501), wherein the heat transfer is stronger when the large-scale wind faces the steeper side of the ratchets. We reveal that the reason for the reversed trend for VC as compared to RBC is that the flow is less turbulent in VC at the same 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628072522266-0966:S0022112019004464:S0022112019004464_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. Thus, in VC the heat transport is driven primarily by the coherent LSCR, while in RBC the ejected thermal plumes aided by gravity are the essential carrier of heat. The present work provides opportunities for control of heat transport in engineering and geophysical flows.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We explore the dynamics of inclined temporal gravity currents using direct numerical simulation, and find that the current creates an environment in which the flux Richardson number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, gradient Richardson number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and turbulent flux coefficient 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 are constant across a large portion of the depth. Changing the slope angle 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 modifies these mixing parameters, and the flow approaches a maximum Richardson number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 as 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 at which the entrainment coefficient 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. The turbulent Prandtl number remains 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for all slope angles, demonstrating that 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is not caused by a switch-off of the turbulent buoyancy flux as conjectured by Ellison (〈span〉J. Fluid Mech.〈/span〉, vol. 2, 1957, pp. 456–466). Instead, 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 occurs as the result of the turbulence intensity going to zero as 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline11.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, due to the flow requiring larger and larger shear to maintain the same level of turbulence. We develop an approximate model valid for small 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline12.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 which is able to predict accurately 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline13.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline14.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline15.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 as a function of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline16.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and their maximum attainable values. The model predicts an entrainment law of the form 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190627132031350-0413:S0022112019004300:S0022112019004300_inline17.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, which is in good agreement with the simulation data. The simulations and model presented here contribute to a growing body of evidence that an approach to a marginally or critically stable, relatively weakly stratified equilibrium for stratified shear flows may well be a generic property of turbulent stratified flows.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Ice scallops are a small-scale (5–20 cm) quasi-periodic ripple pattern that occurs at the ice–water interface. Previous work has suggested that scallops form due to a self-reinforcing interaction between an evolving ice-surface geometry, an adjacent turbulent flow field and the resulting differential melt rates that occur along the interface. In this study, we perform a series of laboratory experiments in a refrigerated flume to quantitatively investigate the mechanisms of scallop formation and evolution in high resolution. Using particle image velocimetry, we probe an evolving ice–water boundary layer at sub-millimetre scales and 15 Hz frequency. Our data reveal three distinct regimes of ice–water interface evolution: a transition from flat to scalloped ice; an equilibrium scallop geometry; and an adjusting scallop interface. We find that scalloped-ice geometry produces a clear modification to the ice–water boundary layer, characterized by a time-mean recirculating eddy feature that forms in the scallop trough. Our primary finding is that scallops form due to a self-reinforcing feedback between the ice-interface geometry and shear production of turbulent kinetic energy in the flow interior. The length of this shear production zone is therefore hypothesized to set the scallop wavelength.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Direct numerical simulation (DNS) is performed for two wall-bounded flow configurations: laminar Couette flow at 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and turbulent channel flow at 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the shear stress at the wall. The top wall is smooth and the bottom wall is a realistically rough superhydrophobic surface (SHS), generated from a three-dimensional surface profile measurement. The air–water interface, which is assumed to be flat, is simulated using the volume-of-fluid (VOF) approach. The two flow cases are studied with varying interface heights 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 to understand its effect on slip and drag reduction (〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉). For the laminar Couette flow case, the presence of the surface roughness is felt up to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 of the channel height in the wall-normal direction. Nonlinear dependence of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 on 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is observed with three distinct regions. A nonlinear curve fit is obtained for gas fraction 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 as a function of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline11.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 determines the amount of slip area exposed to the flow. A power law fit is obtained from the data for the effective slip length as a function of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline12.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and is compared to those derived for structured geometry. For the turbulent channel flow, statistics of the flow field are compared to that of a smooth wall to understand the effects of roughness and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline13.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. Four cases are simulated ranging from fully wetted to fully covered and two intermediate regions in between. Scaling laws for slip length, slip velocity, roughness function and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline14.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 are obtained for different penetration depths and are compared to past work for structured geometry. 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190628070320625-0031:S0022112019004191:S0022112019004191_inline15.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is shown to depend on a competing effect between slip velocity and turbulent losses due to the Reynolds shear stress contribution. Presence of trapped air in the cavities significantly alters near-wall flow physics where we examine near-wall structures and propose a physical mechanism for their behaviour. The fully wetted roughness increases the peak value of turbulent intensities, whereas the presence of the interface suppresses them. The pressure fluctuations have competing contributions between turbulent pressure fluctuations and stagnation due to asperities, the near-wall structure is altered and breaks down with increasing slip. Overall, there exists a competing effect between the interface and the asperities, the interface suppresses turbulence whereas the asperities enhance them. The present work demonstrates DNS over a realistic multiphase SHS for the first time, to the best of our knowledge.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We developed a numerical method for the set of equations governing fully compressible convection in the limit of infinite Prandtl numbers. Reduced models have also been analysed, such as the anelastic approximation and the anelastic liquid approximation. The tests of our numerical schemes against self-consistent criteria have shown that our numerical simulations are consistent from the point of view of energy dissipation, heat transfer and entropy budget. The equation of state of an ideal gas has been considered in this work. Specific effects arising because of the compressibility of the fluid are studied, like the scaling of viscous dissipation and the scaling of the heat flux contribution due to the mechanical power exerted by viscous forces. We analysed the solutions obtained with each model (fully compressible model, anelastic and anelastic liquid approximations) in a wide range of dimensionless parameters and determined the errors induced by each approximation with respect to the fully compressible solutions. Based on a rationale on the development of the thermal boundary layers, we can explain reasonably well the differences between the fully compressible and anelastic models, in terms of both the heat transfer and viscous dissipation dependence on compressibility. This could be mostly an effect of density variations on thermal diffusivity. Based on the different forms of entropy balance between exact and anelastic models, we find that a necessary condition for convergence of the anelastic results to the exact solutions is that the product 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 must be small compared to unity, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the ratio of the superadiabatic temperature difference to the adiabatic difference, and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the ratio of the superadiabatic heat flux to the heat flux conducted along the adiabat. The same condition seems also to be associated with a convergence of the computed heat fluxes. Concerning the anelastic liquid approximation, we confirm previous estimates by Anufriev 〈span〉et al.〈/span〉 (〈span〉Phys. Earth Planet. Inter.〈/span〉, vol. 152, 2005, pp. 163–190) and find that its results become generally close to those of the fully compressible model when 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is small compared to unity, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the isobaric thermal expansion coefficient, 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the temperature (here 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for an ideal gas) and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190625082702251-0920:S0022112019004208:S0022112019004208_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the dissipation number.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Progress in roughness research, mapping any given roughness geometry to its fluid dynamic behaviour, has been hampered by the lack of accurate and direct measurements of skin-friction drag, especially in open systems. The Taylor–Couette (TC) system has the benefit of being a closed system, but its potential for characterizing irregular, realistic, three-dimensional (3-D) roughness has not been previously considered in depth. Here, we present direct numerical simulations (DNSs) of TC turbulence with sand grain roughness mounted on the inner cylinder. The model proposed by Scotti (〈span〉Phys. Fluids〈/span〉, vol. 18, 031701, 2006) has been modified to simulate a random rough surface of monodisperse sand grains. Taylor numbers range from 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉(corresponding to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉) to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 (〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉). We focus on the influence of the roughness height 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 in the transitionally rough regime, through simulations of TC with rough surfaces, ranging from 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 up to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. We analyse the global response of the system, expressed both by the dimensionless angular velocity transport 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and by the friction factor 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. An increase in friction with increasing roughness height is accompanied with enhanced plume ejection from the inner cylinder. Subsequently, we investigate the local response of the fluid flow over the rough surface. The equivalent sand grain roughness 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is calculated to be 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline11.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline12.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the size of the sand grains. We find that the downwards shift of the logarithmic layer, due to transitionally rough sand grains exhibits remarkably similar behaviour to that of the Nikuradse (〈span〉VDI-Forsch.〈/span〉, vol. 361, 1933) data of sand grain roughness in pipe flow, regardless of the Taylor number dependent constants of the logarithmic layer. Furthermore, we find that the dynamical effects of the sand grains are contained to the roughness sublayer 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline13.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 with 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621104521411-0582:S0022112019003768:S0022112019003768_inline14.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Geometric, kinematic and dynamic properties of focusing deep-water surface gravity wave packets are examined in a simplified model with the intent of deriving a wave breaking threshold parameter. The model is based on the spatial modified nonlinear Schrödinger equation of Dysthe (〈span〉Proc. R. Soc. Lond.〈/span〉 A, vol. 369 (1736), 1979, pp. 105–114). The evolution of initially narrow-banded and weakly nonlinear chirped Gaussian wave packets are examined, by means of a trial function and a variational procedure, yielding analytic solutions describing the approximate evolution of the packet width, amplitude, asymmetry and phase during focusing. A model for the maximum free surface gradient, as a function of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621105221417-0357:S0022112019004282:S0022112019004282_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621105221417-0357:S0022112019004282:S0022112019004282_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, for 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621105221417-0357:S0022112019004282:S0022112019004282_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 the linear prediction of the maximum slope at focusing and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621105221417-0357:S0022112019004282:S0022112019004282_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 the non-dimensional packet bandwidth, is proposed and numerically examined, indicating a quasi-self-similarity of these focusing events. The equations of motion for the fully nonlinear potential flow equations are then integrated to further investigate these predictions. It is found that a model of this form can characterize the bulk partitioning of 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621105221417-0357:S0022112019004282:S0022112019004282_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 phase space, between non-breaking and breaking waves, serving as a breaking criterion. Application of this result to better understanding air–sea interaction processes is discussed.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We conduct direct numerical simulations (DNS) of the Cahn–Hilliard–Navier–Stokes (CHNS) equations to investigate the statistical properties of a turbulent phase-separating symmetric binary-fluid mixture. Turbulence causes an arrest of the phase separation which leads to the formation of a statistically steady emulsion. We characterise turbulent velocity fluctuations in an emulsion for different values of the Reynolds number and the Weber number. Our scale-by-scale kinetic energy budget analysis shows that the interfacial terms in the CHNS equations provide an alternative route for the kinetic energy transfer. By studying the probability distribution function (p.d.f.) of the energy dissipation rate, the vorticity magnitude and the joint-p.d.f. of the velocity-gradient invariants we show that the statistics of the turbulent fluctuations do not change with the Weber number.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉With the aim to characterize the near-wall flow structures and their interaction with large-scale motions in the log-law region, time-resolved planar and volumetric flow field measurements were performed in the near-wall and log-law region of an adverse pressure gradient turbulent boundary layer following a zero pressure gradient turbulent boundary layer at a friction Reynolds number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621113954055-0112:S0022112019004087:S0022112019004087_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. Due to the high spatial and temporal resolution of the measurements, it was possible to resolve and identify uniform-momentum zones in the region 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621113954055-0112:S0022112019004087:S0022112019004087_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 or 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621113954055-0112:S0022112019004087:S0022112019004087_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and to relate them with well known coherent flow motions near the wall. The space–time results confirm that the turbulent superstructures have a strong impact even on the very near-wall flow motion and also their alternating appearance in time and intensity could be quantified over long time sequences. Using the time record of the velocity field, rare localized separation events appearing in the viscous sublayer were also analysed. By means of volumetric particle tracking velocimetry their three-dimensional topology and dynamics could be resolved. Based on the results, a conceptual model was deduced that explains their rare occurrence, topology and dynamics by means of a complex interaction process between low-momentum turbulent superstructures, near-wall low-speed streaks and tilted longitudinal and spanwise vortices located in the near-wall region.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We experimentally investigate the extensional flow of a sheet – or curtain – of viscoelastic liquid falling freely from a slot at constant flow rate under gravity. Extruded liquids are aqueous solutions of flexible polyethylene oxide (PEO) and of semi-rigid partially hydrolysed polyacrylamide (HPAM) with low shear viscosities. Velocimetry measurements reveal that the mean velocity field 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 (where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the distance from the slot exit) does not reduce to a free fall. More precisely, we show that the liquid falls initially with sub-gravitational accelerations up to a distance from the slot which scales as 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 (where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is gravity and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the extensional relaxation time of the liquid) due to the stretching of polymer molecules. Beyond this elastic length, inertia dominates and the local acceleration reaches the asymptotic free-fall value 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. The length of the sub-gravitational part of the curtain is shown to be much larger than the equivalent viscous length 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for Newtonian liquids of density 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and dynamic viscosity 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 which is usually small compared to the curtain length. By analogy with Newtonian curtains, we show that the velocity field 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621102720940-0917:S0022112019003896:S0022112019003896_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 rescales on a master curve. Besides, the flow is shown to be only weakly affected by the history of polymer deformations in the die upstream of the curtain. Furthermore, investigations on the curtain stability reveal that polymer addition reduces the minimum flow rate required to maintain a continuous sheet of liquid.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Previous experiments have revealed that shock waves driven through dissipative media may become unstable, for example, in granular gases, and in molecular gases undergoing strong relaxation effects. The current paper addresses this problem of shock stability at the Euler and Navier–Stokes continuum levels in a system of disks (two-dimensional) undergoing activated inelastic collisions. The dynamics of shock formation and stability is found to be in very good agreement with earlier molecular dynamic simulations (Sirmas & Radulescu, 〈span〉Phys. Rev.〈/span〉 E, vol. 91, 2015, 023003). It was found that the modelling of shock instability requires the introduction of molecular noise for its development and sustenance. This is confirmed in two stability problems. In the first, the evolution of shock formation dynamics is monitored without noise, with only initial noise and with continuous molecular noise. Only the latter reproduces the results of shock instability of molecular dynamics simulations. In the second problem, the steady travelling wave solution is obtained for the shock structure in the inviscid and viscous limits and its nonlinear stability is studied with and without molecular fluctuations, again showing that instability can be sustained only in the presence of fluctuations. The continuum results show that instability takes the form of a rippled front of a wavelength comparable with the relaxation thickness of the steady shock wave, at scales at which molecular fluctuations become important, in excellent agreement with the molecular dynamic simulations.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We performed two-way coupled direct numerical simulations of turbulent channel flow with Lagrangian tracking of small, heavy spheres at a dimensionless gravitational acceleration of 0.077 in wall units, which is based on the flow condition in the experiment by Gerashchenko 〈span〉et al.〈/span〉 (〈span〉J. Fluid Mech.〈/span〉, vol. 617, 2008, pp. 255–281). We removed deposited particles after several collisions with the lower wall and then released new particles near the upper wall to observe direct interactions between particles and coherent structures of near-wall turbulence during gravitational settling through the mean shear. The results indicate that when the Stokes number is approximately 1 on the basis of the Kolmogorov time scale of the flow (〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190624134045701-0463:S0022112019004002:S0022112019004002_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉), the so-called preferential sweeping occurs in association with coherent streamwise vortices, while the effect of crossing trajectories becomes significant for 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190624134045701-0463:S0022112019004002:S0022112019004002_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. Consequently, in either case, the settling particles deposit on the wall without strong accumulation in low-speed streaks in the viscous sublayer. When particles settle through near-wall turbulence from the upper wall, more small-scale vortical structures are generated in the outer layer as low-speed fluid is pulled farther in the direction of gravity, while the opposite is true near the lower wall.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉Streaks have been found to be an important part of wall-turbulence dynamics. In this paper, we extend the analysis for unbounded shear flows, in particular a Mach 0.4 round jet, using measurements taken using dual-plane, time-resolved, stereoscopic particle image velocimetry (PIV) taken at pairs of jet cross-sections, allowing the evaluation of the cross-spectral density of streamwise velocity fluctuations resolved into azimuthal Fourier modes. From the streamwise velocity results, two analyses are performed: the evaluation of wavenumber spectra (assuming Taylor’s hypothesis for the streamwise coordinate) and a spectral proper orthogonal decomposition (SPOD) of the velocity field using PIV planes in several axial stations. The methods complement each other, leading to the conclusion that large-scale streaky structures are also present in turbulent jets where they experience large growth in the streamwise direction, energetic structures extending up to eight diameters from the nozzle exit. Leading SPOD modes highlight the large-scale, streaky shape of the structures, whose aspect ratio (streamwise over azimuthal length) is approximately 15. The data were further analysed using SPOD, resolvent and transient growth analyses, good agreement being observed between the models and the leading SPOD mode for the wavenumbers considered. The models also indicate that the lift-up mechanism is active in turbulent jets, with streamwise vortices leading to streaks. The results show that large-scale streaks are a relevant part of the jet dynamics.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We study single-phase and particle-laden turbulent channel flows bounded by two incompressible hyper-elastic walls with different deformability at bulk Reynolds number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621111752900-0025:S0022112019004130:S0022112019004130_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. The solid volume fraction of finite-size neutrally buoyant rigid spherical particles considered is 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621111752900-0025:S0022112019004130:S0022112019004130_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. The elastic walls are assumed to be of a neo-Hookean material. A fully Eulerian formulation is employed to model the elastic walls together with a direct-forcing immersed boundary method for the coupling between the fluid and the particles. The data show a significant drag increase and the enhancement of the turbulence activity with growing wall elasticity for both the single-phase and particle-laden flows when compared with the single-phase flow over rigid walls. Drag reduction and turbulence attenuation is obtained, on the other hand, with highly elastic walls when comparing the particle-laden flow with the single-phase flow for the same wall properties; the opposite effect, drag increase, is observed upon adding particles to the flow over less elastic walls. This is explained by investigating the near-wall turbulence, where the strong asymmetry in the magnitude of the wall-normal velocity fluctuations (favouring positive 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621111752900-0025:S0022112019004130:S0022112019004130_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉), is found to push the particles towards the channel centre. The particle layer close to the wall contributes to turbulence production by increasing the wall-normal velocity fluctuations, so that in the absence of this layer, smaller wall deformations and in turn turbulence attenuation is observed. For a moderate wall elasticity, we increase the particle volume fraction up to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621111752900-0025:S0022112019004130:S0022112019004130_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and find that particle migration away from the wall is the cause of turbulence attenuation with respect to the flow over rigid walls. However, for this higher volume fractions, the particle induced stress compensates for the decreasing Reynolds shear stress, resulting in a higher overall drag for the case with elastic walls. The effect of the wall elasticity on the overall drag reduces significantly with increasing particle volume fraction.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We present large-eddy simulation (LES) of flow past different airfoils with 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, based on the free-stream velocity and airfoil chord length, ranging from 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. To avoid the challenging resolution requirements of the near-wall region, we develop a virtual wall model in generalized curvilinear coordinates and incorporate the non-equilibrium effects via proper treatment of the momentum equations. It is demonstrated that the wall model dynamically captures the instantaneous skin-friction vector field on arbitrary curved surfaces at the resolved scale. By combining the present wall model with the stretched-vortex subgrid-scale model, we apply the wall-modelled LES approach to three different airfoil cases, spanning different geometrical parameters, different attack angles and low to high 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. The numerical results are verified with direct numerical simulation (DNS) at low 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, and validated with experiment data at higher 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, including typical aerodynamic properties such as pressure coefficient distributions, velocity components and also more challenging measurements such as skin-friction coefficient and Reynolds stresses. All comparisons show reasonable agreement, providing a measure of validity that enables us to further probe simulation results into aspects of flow physics that are not available from experiments. Two techniques to quantify hitherto unexplored physics of flows past airfoils are employed: one is the construction of the anisotropy invariant map, and the second is skin-friction portraits with emphasis on flow transition and unsteady separation along the airfoil surface. The anisotropy maps for all three 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 cases, show clearly that a portion of the flow field is aligned along the axisymmetric expansion line, corresponding to the turbulent boundary layer log-law behaviour and the appearance of turbulent transition. The instantaneous skin-friction portraits reveal a monotonic shrinking of the near wall structure scale. At 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, the interaction between the primary separation bubble and the secondary separation bubble contributes to turbulent transition, similar to the case of flow past a cylinder. At higher 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, the primary separation breaks into several small separation bubbles. At even higher 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190621103821391-0158:S0022112019003604:S0022112019003604_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, near the turbulent separation, the skin-friction lines show small-scale reversal flows that are similar to those observed in DNS of the flat plate turbulent separation. A notable feature of turbulent separation in flow past an airfoil is the appearance of turbulence structures and small-scale reversal flows in the spanwise direction due to the vortex shedding behaviour.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉In the framework of the complete formulation of the conjugate problem, the liquid–gas flow structure arising upon local heating using thermal sources is investigated numerically. The two-layer system is confined by solid impermeable walls. The Navier–Stokes equations in the Boussinesq approximation in the ‘streamfunction–vorticity’ variables are used to describe the media motion. The dynamic conditions at the interface are formulated in terms of the tangential and normal velocities, while the temperature conditions at the external boundaries of the system take into account the presence of local heaters. The influence of the number of heaters and heating modes on the dynamics and character of the appearing convective regimes is analysed. The steady and commutated heating modes for one and two heaters arranged at the lower boundary are investigated. The heating initiates convective and thermocapillary mechanisms causing the fluid motion. Transient regimes with the successive formation of two-vortex, quadruple-vortex and two-vortex flows are observed before the stabilization of the system in the uniform heating mode. A stable thermocapillary deflection appears at the interface above the heater. The commutated mode of heating entails oscillations of the interface with a change in the deflection form and the formation of travelling vortices in the fluids. The impact of particular mechanisms on the flow patterns is analysed. The paper presents typical distributions of the velocity and temperature fields in the system and the position of the interface for the considered cases.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉In the context of dynamic wetting, wall slip is often treated as a microscopic effect for removing viscous stress singularity at a moving contact line. In most drop spreading experiments, however, a considerable amount of slip may occur due to the use of polymer liquids such as silicone oils, which may cause significant deviations from the classical Tanner–de Gennes theory. Here we show that many classical results for complete wetting fluids may no longer hold due to wall slip, depending crucially on the extent of de Gennes’s slipping ‘foot’ to the relevant length scales at both the macroscopic and microscopic levels. At the macroscopic level, we find that for given liquid height 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 and slip length 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline2.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, the apparent dynamic contact angle 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline3.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 can change from Tanner’s law 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline4.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline5.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 to the strong-slip law 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline6.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 for 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline7.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline8.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the capillary number and 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline9.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the macroscopic length scale. Such a no-slip-to-slip transition occurs at the critical capillary number 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline10.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, accompanied by the switch of the ‘foot’ of size 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline11.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 from the inner scale to the outer scale with respect to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline12.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. A more generalized dynamic contact angle relationship is also derived, capable of unifying Tanner’s law and the strong-slip law under 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline13.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉. We not only confirm the two distinct wetting laws using many-body dissipative particle dynamics simulations, but also provide a rational account for anomalous departures from Tanner’s law seen in experiments (Chen, 〈span〉J. Colloid Interface Sci〈/span〉., vol. 122, 1988, pp. 60–72; Albrecht 〈span〉et al.〈/span〉, 〈span〉Phys. Rev. Lett.〈/span〉, vol. 68, 1992, pp. 3192–3195). We also show that even for a common spreading drop with small macroscopic slip, slip effects can still be microscopically strong enough to change the microstructure of the contact line. The structure is identified to consist of a strongly slipping precursor film of length 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline14.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 followed by a mesoscopic ‘foot’ of width 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline15.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 ahead of the macroscopic wedge, where 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline16.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 is the molecular length. It thus turns out that it is the ‘foot’, rather than the film, contributing to the microscopic length in Tanner’s law, in accordance with the experimental data reported by Kavehpour 〈span〉et al.〈/span〉 (〈span〉Phys. Rev. Lett.〈/span〉, vol. 91, 2003, 196104) and Ueno 〈span〉et al.〈/span〉 (〈span〉Trans. ASME J. Heat Transfer〈/span〉, vol. 134, 2012, 051008). The advancement of the microscopic contact line is still led by the film whose length can grow as the 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline17.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 power of time due to 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619140754267-0248:S0022112019003525:S0022112019003525_inline18.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉, as supported by the experiments of Ueno 〈span〉et al.〈/span〉 and Mate (〈span〉Langmuir〈/span〉, vol. 28, 2012, pp. 16821–16827). The present work demonstrates that the behaviour of a moving contact line can be strongly influenced by wall slip. Such slip-mediated dynamic wetting might also provide an alternative means for probing slippery surfaces.〈/p〉〈/div〉

Description: 〈div data-abstract-type="normal"〉〈p〉We numerically investigated the unsteady dynamics of a two-dimensional airfoil undergoing a continuous, prescribed pitch-up motion and freely translating as a response to aerodynamic forces and the gravity field. The pitch-up motion was applied about an axis located 〈span〉〈span〉〈img data-mimesubtype="gif" data-type="simple" src="http://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20190619142124772-0727:S002211201900421X:S002211201900421X_inline1.gif"〉 〈span data-mathjax-type="texmath"〉 〈/span〉 〈/span〉〈/span〉 chord away from the leading edge and was parameterized using the shape change number, with a Reynolds number set to 2000. It was shown that the minimum kinetic energy reached by the airfoil depends stochastically and asymptotically on shape change numbers for values below and above 1, respectively. Very low kinetic energy levels (close to zero) can be reached in both stochastic and asymptotic regions but high shape change numbers are accompanied by significant gain in altitude which may be undesirable from a practical perspective. Rather, shape change numbers in the range [0.1–0.3] allow us to reach relatively low levels of kinetic energy for close perching locations. We showed that highly nonlinear fluid–structure interactions induced by massive flow separations and strong vortices are conducive to low kinetic energy, but responsible for the stochastic dependence of kinetic energy to shape change number, which can make perching manoeuvres hardly controllable for flying vehicles.〈/p〉〈/div〉

Description: 〈p〉In engineering, the "softness" of an object, as measured by an indenter, manifests as two measurable parameters: (i) indentation depth and (ii) contact area. For humans, softness is not well defined, although it is believed that perception depends on the same two parameters. Decoupling their relative contributions, however, has not been straightforward because most bulk—"off-the-shelf"—materials exhibit the same ratio between the indentation depth and contact area. Here, we decoupled indentation depth and contact area by fabricating elastomeric slabs with precise thicknesses and microstructured surfaces. Human subject experiments using two-alternative forced-choice and magnitude estimation tests showed that the indentation depth and contact area contributed independently to perceived softness. We found an explicit relationship between the perceived softness of an object and its geometric properties. Using this approach, it is possible to design objects for human interaction with a desired level of perceived softness.〈/p〉

Description: 〈p〉The electronic energy and dynamics of solvated electrons, the simplest yet elusive chemical species, is of interest in chemistry, physics, and biology. Here, we present the electron binding energy distributions of solvated electrons in liquid water, methanol, and ethanol accurately measured using extreme ultraviolet (EUV) photoelectron spectroscopy of liquids with a single-order high harmonic. The distributions are Gaussian in all cases. Using the EUV and UV photoelectron spectra of solvated electrons, we succeeded in retrieving sharp electron kinetic energy distributions from the spectra broadened and energy shifted by inelastic scattering in liquids, overcoming an obstacle in ultrafast UV photoelectron spectroscopy of liquids. The method is demonstrated for the benchmark systems of charge transfer to solvent reaction and ultrafast internal conversion of hydrated electron from the first excited state.〈/p〉

Description: 〈p〉Topological surface states (TSSs) in a topological insulator are expected to be able to produce a spin-orbit torque that can switch a neighboring ferromagnet. This effect may be absent if the ferromagnet is conductive because it can completely suppress the TSSs, but it should be present if the ferromagnet is insulating. This study reports TSS-induced switching in a bilayer consisting of a topological insulator Bi〈sub〉2〈/sub〉Se〈sub〉3〈/sub〉 and an insulating ferromagnet BaFe〈sub〉12〈/sub〉O〈sub〉19〈/sub〉. A charge current in Bi〈sub〉2〈/sub〉Se〈sub〉3〈/sub〉 can switch the magnetization in BaFe〈sub〉12〈/sub〉O〈sub〉19〈/sub〉 up and down. When the magnetization is switched by a field, a current in Bi〈sub〉2〈/sub〉Se〈sub〉3〈/sub〉 can reduce the switching field by ~4000 Oe. The switching efficiency at 3 K is 300 times higher than at room temperature; it is ~30 times higher than in Pt/BaFe〈sub〉12〈/sub〉O〈sub〉19〈/sub〉. These strong effects originate from the presence of more pronounced TSSs at low temperatures due to enhanced surface conductivity and reduced bulk conductivity.〈/p〉

Description: 〈p〉The in situ two-dimensional (2D) and 3D imaging of the chemical speciation of organic fossils is an unsolved problem in paleontology and cultural heritage. Here, we use x-ray Raman scattering (XRS)–based imaging at the carbon K-edge to form 2D and 3D images of the carbon chemistry in two exceptionally preserved specimens, a fossil plant dating back from the Carboniferous and an ancient insect entrapped in 53-million-year-old amber. The 2D XRS imaging of the plant fossil reveals a homogeneous chemical composition with micrometric "pockets" of preservation, likely inherited from its geological history. The 3D XRS imaging of the insect cuticle displays an exceptionally well preserved remaining chemical signature typical of polysaccharides such as chitin around a largely hollowed-out inclusion. Our results open up new perspectives for in situ chemical speciation imaging of fossilized organic materials, with the potential to enhance our understanding of organic specimens and their paleobiology.〈/p〉

Description: 〈p〉The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure.〈/p〉

Description: 〈sec〉〈st〉Electron energy bands of crystalline solids generically exhibit degeneracies called band-structure nodes. Here, we introduce non-Abelian topological charges that characterize line nodes inside the momentum space of〈/st〉〈p〉〈b〉-symmetric crystalline metals with weak spin-orbit coupling. We show that these are quaternion charges, similar to those describing disclinations in biaxial nematics. Starting from two-band considerations, we develop the complete many-band description of nodes in the presence of 〈/b〉 〈b〉and mirror symmetries, which allows us to investigate the topological stability of nodal chains in metals. The non-Abelian charges put strict constraints on the possible nodal line configurations. Our analysis goes beyond the standard approach to band topology, and implies the existence of 1D topological phases not present in existing classifications.〈/b〉〈/p〉〈/sec〉

Description: 〈p〉Investigating slow earthquake activity in subduction zones provides insight into the slip behavior of megathrusts, which can provide important clues about the rupture extent of future great earthquakes. Using the S-net ocean-bottom seismograph network along the Japan Trench, we mapped a detailed distribution of tectonic tremors, which coincided with very-low-frequency earthquakes and a slow slip event. Compiling these and other related observations, including repeating earthquakes and earthquake swarms, we found that the slow earthquake distribution is complementary to the Tohoku-Oki earthquake rupture. We used our observations to divide the megathrust in the Japan Trench into three along-strike segments characterized by different slip behaviors. We found that the rupture of the Tohoku-Oki earthquake, which nucleated in the central segment, was terminated by the two adjacent segments.〈/p〉

Description: 〈p〉Stimuli-responsive materials activated by biological signals play an increasingly important role in biotechnology applications. We exploit the programmability of CRISPR-associated nucleases to actuate hydrogels containing DNA as a structural element or as an anchor for pendant groups. After activation by guide RNA–defined inputs, Cas12a cleaves DNA in the gels, thereby converting biological information into changes in material properties. We report four applications: (i) branched poly(ethylene glycol) hydrogels releasing DNA-anchored compounds, (ii) degradable polyacrylamide-DNA hydrogels encapsulating nanoparticles and live cells, (iii) conductive carbon-black–DNA hydrogels acting as degradable electrical fuses, and (iv) a polyacrylamide-DNA hydrogel operating as a fluidic valve with an electrical readout for remote signaling. These materials allow for a range of in vitro applications in tissue engineering, bioelectronics, and diagnostics.〈/p〉

Description: 〈p〉Understanding genomic variation and population structure of 〈i〉Plasmodium falciparum〈/i〉 across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 〈i〉P. falciparum〈/i〉 isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite’s origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against 〈i〉P. falciparum〈/i〉 malaria.〈/p〉

Description: 〈p〉In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest 〈i〉Ceratitis capitata〈/i〉 (Mediterranean fruit fly, Medfly) we identified a Y-linked gene, 〈i〉Maleness-on the-Y〈/i〉 (〈i〉MoY〈/i〉), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of 〈i〉MoY〈/i〉 in XY embryos causes feminization whereas overexpression of 〈i〉MoY〈/i〉 in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. 〈i〉MoY〈/i〉 is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.〈/p〉

Description: 〈p〉Membraneless organelles involved in RNA processing are biomolecular condensates assembled by phase separation. Despite the important role of intrinsically disordered protein regions (IDRs), the specific interactions underlying IDR phase separation and its functional consequences remain elusive. To address these questions, we used minimal condensates formed from the C-terminal disordered regions of two interacting translational regulators, FMRP and CAPRIN1. Nuclear magnetic resonance spectroscopy of FMRP-CAPRIN1 condensates revealed interactions involving arginine-rich and aromatic-rich regions. We found that different FMRP serine/threonine and CAPRIN1 tyrosine phosphorylation patterns control phase separation propensity with RNA, including subcompartmentalization, and tune deadenylation and translation rates in vitro. The resulting evidence for residue-specific interactions underlying co–phase separation, phosphorylation-modulated condensate architecture, and enzymatic activity within condensates has implications for how the integration of signaling pathways controls RNA processing and translation.〈/p〉

Description: 〈p〉SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD〈sup〉+〈/sup〉) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show, feature self-association–dependent NAD〈sup〉+〈/sup〉 cleavage activity associated with cell death signaling. We further show that SARM1 SAM (sterile alpha motif) domains form an octamer essential for axon degeneration that contributes to TIR domain enzymatic activity. The crystal structures of ribose and NADP〈sup〉+〈/sup〉 (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site. NAD〈sup〉+〈/sup〉 cleavage by TIR domains is therefore a conserved feature of animal and plant cell death signaling pathways.〈/p〉

Description: 〈p〉The near-Earth asteroid (162173) Ryugu is a 900-m-diameter dark object expected to contain primordial material from the solar nebula. The Mobile Asteroid Surface Scout (MASCOT) landed on Ryugu’s surface on 3 October 2018. We present images from the MASCOT camera (MASCam) taken during the descent and while on the surface. The surface is covered by decimeter- to meter-sized rocks, with no deposits of fine-grained material. Rocks appear either bright, with smooth faces and sharp edges, or dark, with a cauliflower-like, crumbly surface. Close-up images of a rock of the latter type reveal a dark matrix with small, bright, spectrally different inclusions, implying that it did not experience extensive aqueous alteration. The inclusions appear similar to those in carbonaceous chondrite meteorites.〈/p〉

Description: 〈p〉Van Meter 〈i〉et al〈/i〉. (Reports, 27 April 2018, p. 427) warn that achieving nitrogen reduction goals in the Gulf of Mexico will take decades as a result of legacy nitrogen effects. We discuss limitations of the modeling approach and demonstrate that legacy effects ranging from a few years to decades are equally consistent with observations. The presented time scales for system recovery are therefore highly uncertain.〈/p〉

Description: 〈p〉Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire 〈i〉Plasmodium berghei〈/i〉 life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.〈/p〉

Description: 〈p〉Soil organisms represent the most biologically diverse community on land and govern the turnover of the largest organic matter pool in the terrestrial biosphere. The highly complex nature of these communities at local scales has traditionally obscured efforts to identify unifying patterns in global soil biodiversity and biogeochemistry. As a result, environmental covariates have generally been used as a proxy to represent the variation in soil community activity in global biogeochemical models. Yet over the past decade, broad-scale studies have begun to see past this local heterogeneity to identify unifying patterns in the biomass, diversity, and composition of certain soil groups across the globe. These unifying patterns provide new insights into the fundamental distribution and dynamics of organic matter on land.〈/p〉

Description: 〈p〉Welding of ceramics is a key missing component in modern manufacturing. Current methods cannot join ceramics in proximity to temperature-sensitive materials like polymers and electronic components. We introduce an ultrafast pulsed laser welding approach that relies on focusing light on interfaces to ensure an optical interaction volume in ceramics to stimulate nonlinear absorption processes, causing localized melting rather than ablation. The key is the interplay between linear and nonlinear optical properties and laser energy–material coupling. The welded ceramic assemblies hold high vacuum and have shear strengths comparable to metal-to-ceramic diffusion bonds. Laser welding can make ceramics integral components in devices for harsh environments as well as in optoelectronic and/or electronic packages needing visible-radio frequency transparency.〈/p〉

Description: 〈p〉The concept of topological phases is a powerful framework for characterizing ground states of quantum many-body systems that goes beyond the paradigm of symmetry breaking. Topological phases can appear in condensed-matter systems naturally, whereas the implementation and study of such quantum many-body ground states in artificial matter require careful engineering. Here, we report the experimental realization of a symmetry-protected topological phase of interacting bosons in a one-dimensional lattice and demonstrate a robust ground state degeneracy attributed to protected zero-energy edge states. The experimental setup is based on atoms trapped in an array of optical tweezers and excited into Rydberg levels, which gives rise to hard-core bosons with an effective hopping generated by dipolar exchange interaction.〈/p〉

Description: 〈p〉Ballard 〈i〉et al〈/i〉. argue that our prediction of a 30-year or longer recovery time for Gulf of Mexico water quality is highly uncertain, and that much shorter time lags are equally likely. We demonstrate that their argument, based on the use of a two-component regression model, does not sufficiently consider fundamental watershed processes or multiple lines of evidence suggesting the existence of decadal-scale lags.〈/p〉

Description: 〈p〉Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1 receptor (TIR) domains of NLRs are enzymes capable of degrading nicotinamide adenine dinucleotide in its oxidized form (NAD〈sup〉+〈/sup〉). Both cell death induction and NAD〈sup〉+〈/sup〉 cleavage activity of plant TIR domains require known self-association interfaces and a putative catalytic glutamic acid that is conserved in both bacterial TIR NAD〈sup〉+〈/sup〉-cleaving enzymes (NADases) and the mammalian SARM1 (sterile alpha and TIR motif containing 1) NADase. We identify a variant of cyclic adenosine diphosphate ribose as a biomarker of TIR enzymatic activity. TIR enzymatic activity is induced by pathogen recognition and functions upstream of the genes 〈i〉enhanced disease susceptibility 1〈/i〉 (〈i〉EDS1〈/i〉) and 〈i〉N requirement gene 1〈/i〉 (〈i〉NRG1〈/i〉), which encode regulators required for TIR immune function. Thus, plant TIR-NLR receptors require NADase function to transduce recognition of pathogens into a cell death response.〈/p〉

Description: 〈p〉How do neurons encode long-term memories? Bilateral imaging of neuronal activity in the mouse hippocampus reveals that, from one day to the next, ~40% of neurons change their responsiveness to cues, but thereafter only 1% of cells change per day. Despite these changes, neuronal responses are resilient to a lack of exposure to a previously completed task or to hippocampus lesions. Unlike individual neurons, the responses of which change after a few days, groups of neurons with inter- and intrahemispheric synchronous activity show stable responses for several weeks. The likelihood that a neuron maintains its responsiveness across days is proportional to the number of neurons with which its activity is synchronous. Information stored in individual neurons is relatively labile, but it can be reliably stored in networks of synchronously active neurons.〈/p〉

Description: 〈p〉How the microbiota modulate immune functions remains poorly understood. Mucosal-associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in germ-free mice. Here, we show that commensal bacteria govern murine MAIT intrathymic development, as MAIT cells did not recirculate to the thymus. MAIT development required 〈i〉RibD〈/i〉 expression in bacteria, indicating that production of the MAIT antigen 5-(2-oxopropylideneamino)-6-〈scp〉d〈/scp〉-ribitylaminouracil (5-OP-RU) was necessary. 5-OP-RU rapidly traveled from mucosal surfaces to the thymus, where it was captured by the major histocompatibility complex class Ib molecule MR1. This led to increased numbers of the earliest MAIT precursors and the expansion of more mature receptor–related orphan receptor t–positive MAIT cells. Thus, a microbiota-derived metabolite controls development of mucosally targeted T cells, in a process blurring the distinction between exogenous and self-antigens.〈/p〉

Description: 〈p〉Host cell metabolism can be modulated by viral infection, affecting viral survival or clearance. The cellular metabolism rewiring mediated by 〈i〉N〈/i〉〈sup〉6〈/sup〉-methyladenosine (m〈sup〉6〈/sup〉A) modification in virus-host interaction remains largely unknown. Here we report that in response to viral infection, host cells impair the enzymatic activity of RNA m〈sup〉6〈/sup〉A demethylase ALKBH5. This increases the m〈sup〉6〈/sup〉A methylation on α-ketoglutarate dehydrogenase (OGDH) mRNA to reduce its mRNA stability and protein expression. Reduced OGDH decreases the production of metabolite itaconate that is required for viral replication. With reduced OGDH and itaconate production in vivo, ALKBH5-deficient mice display an innate immune response-independent resistance to viral challenge. Our findings reveal that m〈sup〉6〈/sup〉A RNA modification-mediated down-regulation of OGDH-Itaconate pathway reprograms cellular metabolism to inhibit viral replication, proposing potential targets for controlling viral infection.〈/p〉

Description: 〈p〉Artificial intelligence and other data-intensive applications have escalated the demand for data storage and processing. New computing devices, e.g., phase-change random access memory (PCRAM) based neuro-inspired devices, are promising options for breaking the von Neumann barrier by unifying storage with computing in memory cells. However, current PCRAM devices have considerable noise and drift in electrical resistance that erodes the precision and consistency of these devices. We designed a phase-change heterostructure (PCH) consisting of alternately stacked phase-change and confinement nanolayers to suppress the noise and drift, allowing reliable iterative RESET and cumulative SET operations for high-performance neuro-inspired computing. Our PCH architecture is amenable to industrial production as an intrinsic materials solution, without complex manufacturing procedure nor much increased fabrication cost.〈/p〉