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  • Springer  (45,323)
  • American Chemical Society  (33,082)
  • Nature Publishing Group  (4,717)
  • American Institute of Physics (AIP)
  • 2005-2009  (83,122)
  • 1980-1984
  • 2006  (83,122)
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  • 2005-2009  (83,122)
  • 1980-1984
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  • 1
    Publication Date: 2017-04-04
    Description: Secondary minerals of a 91 meters-thick sequence of pillow basalts cored during ODP Leg 195 (Site 1201, West Philippine Basin) were investigated to reconstruct the hydrothermal alteration history and regime. The basement was first buried by red clays, and then by a thick turbidite sequence, thereby isolating it from seawater. The basalts are primitive to moderately fractionated, texturally variable from hypocrystalline and spherulitic to intersertal, sub-ophitic and intergranular. Relic primary minerals are plagioclase, clinopyroxene and opaques. Hydrothermal alteration pervasively affected the basalts, generating secondary clay minerals (mostly glauconite, minor Al-saponite and Fe-beidellite, Na-zeolites, minor alkali-feldspar and calcite. The secondary mineral paragenesis and mutual relationships suggest that the hydrothermal alteration occurred under zeolite-facies conditions, at temperatures 100-150 C. The main phase of alteration occurred under oxidizing conditions, with a high seawater rock ratio, in an open-circulation regime, at temperatures of 30-60 C, with precipitation of abundant glauconite and iddingsite. A later stage of alteration occurred at ca. 70 C, with precipitation of abundant Na-zeolites and minor calcite, in a more restricted circulation regime as a consequence of basement burial under the sedimentary cover, which supplied an altered, Ca-rich and Magma-sulfate-poor water causing precipitation of almost pure calcite.
    Description: Published
    Description: 87-112
    Description: open
    Keywords: west Philippine ; Mineral chemistry ; 04. Solid Earth::04.04. Geology::04.04.05. Mineralogy and petrology ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 2
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    In:  EPIC3The Andes - Active Subduction Orogeny, Frontiers in Earth Sciences, Springer, pp. 3-27, ISBN: 978-3-540-24329-8
    Publication Date: 2014-04-15
    Description: We quantitatively analyse the spatial pattern of deformation partitioning and of temporal accumulation of deformation in the Central Andes (15–26° S) with the aim of identifying those mechanisms responsible for initiating and controlling Cenozoic plateau evolution in this region. Our results show that the differential velocity between upper plate velocity and oceanic plate slab rollback velocity is crucial for determining the amount and rate of shortening, as well as their lateral variability at the leading edge of the upper plate. This primary control is modulated by factors affecting the strength balance between the upper plate lithosphere and the Nazca/South American Plate interface. These factors particularly include a stage of reduced slab dip (33 to 20 Ma) that accelerated shortening and an earlier phase (45 to 33 Ma) of higher trenchward sediment flux that reduced coupling at the plate interface, resulting in slowed shortening and enhanced slab rollback. Because high sediment flux and transfer of convergence into upper plate shortening constitute a negative feedback, we suggest that interruption of this feedback is critical for sustaining high shortening transfer, as observed for the Andes. Although we show that climate trends have no influence on the evolution of the Central Andes, the position of this region in the global arid belt in a low erosion regime is the key that provides this interruption; it inhibits high sediment flux into the trench despite the formation of relief from ongoing shortening. Along-strike variations in Andean shortening are clearly related to changes of the above factors. The spatial pattern of distribution of deformation in the Central Andes, as well as the synchronization of fault systems and the total magnitude of shortening, was mainly controlled by large-scale, inherited upper plate features that constitute zones of weakness in the upper plate leading edge. In summary, only a very particular combination of parameters appears to be able to trigger plateau-style deformation at a convergent continental margin. The combination of these parameters (in particular, differential trench-upper plate velocity evolution, high plate interface coupling from low trench infill, and the lateral distribution of weak zones in the upper plate leading edge) was highly uncommon during the Phanerozoic. This led to very few plateau-style orogens at convergent margins like the Cenozoic Central Andes in South America or, possibly, the Laramide North American Cordillera.
    Repository Name: EPIC Alfred Wegener Institut
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  • 3
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    Nature biotechnology 24 (2006), S. 1048-1049 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 200% ethanol boost from Oz sugar University of Queensland (UQ), Australia, molecular geneticist Robert Birch got more than he bargained for when he introduced a bacterial gene into sugarcane to convert sucrose into its high-value isomer, isomaltulose. In fact, the gene encoding sucrose isomerase, ...
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  • 4
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    Nature biotechnology 24 (2006), S. 1484-1485 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Common bacteria, engineered to safely seek out and kill tumors, may well be the next generation of cancer therapeutics. In this issue, Bettegowda et al. report the genome sequence of one such bacterium, Clostridium novyi-NT, which has been engineered to be non-toxic by deleting the major systemic ...
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  • 5
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    Nature biotechnology 24 (2006), S. 1491-1493 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This June, Basel-based Novartis Pharmaceuticals made a first reconnoiter into antimicrobial antibodies in its quest to find new weapons to fight infections. It paid $569 million to acquire NeuTec Pharmaceuticals of Manchester, UK, and its two late-stage products, both antibody fragments ...
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  • 6
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    Nature biotechnology 24 (2006), S. 1504-1507 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The scarcity of disease in wild plants indicates that the success of plant defense mechanisms in combating pathogen infection rivals that of mammalian immune systems. Although there are some interesting parallels between plant and animal defense strategies—for instance, both groups sacrifice ...
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  • 7
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    Nature biotechnology 24 (2006), S. 1515-1519 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Food and Drug Administration (FDA) has recently rejected new antibiotics for common infections citing the requirement that the drugs intended to treat non-serious infections prove superior to placebo rather than active controls. With the introduction of more stringent statistical criteria, ...
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  • 8
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    Nature biotechnology 24 (2006), S. 1521-1528 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
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  • 9
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    Nature biotechnology 24 (2006), S. 1565-1567 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A support vector machine (SVM) is a computer algorithm that learns by example to assign labels to objects. For instance, an SVM can learn to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and nonfraudulent credit card activity reports. Alternatively, an ...
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  • 10
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb ...
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  • 11
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    Nature biotechnology 24 (2006), S. 1569-1571 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The utility of blue fluorescent protein (BFP) has been limited by its low quantum yield and rapid photobleaching. A library targeting residues neighboring the chromophore yielded a variant with enhanced quantum yield (0.55 versus 0.34), reduced pH sensitivity and a 40-fold increase in ...
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  • 12
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    Nature biotechnology 24 (2006), S. 1551-1557 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting ...
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  • 13
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    Nature biotechnology 24 (2006), S. 1300-1300 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Is it possible that ImClone didn't do its homework on Erbitux's ...
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  • 14
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    Nature biotechnology 24 (2006), S. 1303-1303 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On the average report card a test score of three out of five would usually draw the comment 'could do better'. The admonishment to try harder was also given by some observers to Darmstadt-based Merck KGaA's surprise €10.6- ($13.2)-billion acquisition of Serono on September 21. Although ...
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  • 15
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    Nature biotechnology 24 (2006), S. 1081-1081 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech stocks can be white-knuckle volatile, but there is a way you can profit from, or insure against, such rapid and dramatic price changes. Through put and call options, you may not only make more profits, but also buy and sell 'protection' for your investments (with no need for 'knuckle' ...
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  • 16
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    Nature biotechnology 24 (2006), S. 1095-1095 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recent patent applications in tissue engineering ...
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  • 17
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    Nature biotechnology 24 (2006), S. 1091-1094 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Gene patenting has attracted intense scrutiny for decades, raising a host of ethical, legal and economic concerns. Much of the policy debate has focused on seemingly quantifiable and practical concerns about the effect of patents on access to useful technologies in the contexts of both research and ...
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  • 18
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    Nature biotechnology 24 (2006), S. 1322-1323 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: One of the challenges for the future is how to integrate all the DNA microarray data that have been generated and deposited in public databases. We have studied data from two data repositories and identified that only 38% meet necessary quality and data format standards. Our results ...
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  • 19
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    Nature biotechnology 24 (2006), S. 1097-1098 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Of the many differentiated cell types that have been derived in vitro from mouse embryonic stem (ES) cells, among the most intriguing are cells resembling male and female gametes. Such ES cell–derived germ cells have been shown to undergo meiosis to form haploid gametes that can support early ...
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  • 20
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    Nature biotechnology 24 (2006), S. 1352-1354 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The increasingly commercial nature of biomedical research is, rightly or not, a reality of the contemporary research environment. The percentage of biomedical research supported by industry continues to grow, and many public funding agencies now encourage industry partnerships. Although links with ...
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  • 21
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    Nature biotechnology 24 (2006), S. 1359-1361 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant-derived 'essential oils' such as terpenoids are widely used in the fragrance and flavor industries. In this issue, Chappell and colleagues describe an approach for engineering plants that produce elevated levels of commercially relevant terpenoids. They co-express both an enzyme that supplies ...
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  • 22
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    Nature biotechnology 24 (2006), S. 1365-1366 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The rallying cry of early 21st century biomedical science is that new combinations of genomic, proteomic and bioinformatic research will provide deeper insights into disease mechanisms, novel markers for diagnostics and new molecular targets for therapeutic intervention. DNA and protein microarrays ...
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  • 23
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    Nature biotechnology 24 (2006), S. 1374-1376 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Trying to make some sense of it all, But I can see that it makes no sense at all, Is it cool to go to sleep on the floor, 'Cause I don't think that I can take anymore Clowns to the left of me, jokers to the right, Here I am, stuck in the middle with you. Joe Egan and Gerry Rafferty There are ...
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  • 24
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    Nature biotechnology 24 (2006), S. 1448-1448 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 24, 397–400 (2006); published online 29 March 2006; corrected after print 8 November 2006. In the version of this article initially published, on page 399, column 2, paragraph 4, the authors wrongly credited the idea for using cells from nonviable human embryos as an ...
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  • 25
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    Notes: [Auszug] Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene expression throughout myriad cellular processes. However, the DNA binding specificities of only a small fraction of TFs are sufficiently characterized to predict the sequences that they can and cannot bind. ...
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  • 26
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    Notes: [Auszug] Severe acute liver failure, even when transient, must be treated by transplantation and lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) support, but this approach is hindered by a shortage of human hepatocytes. To generate an alternative source of cells for BAL ...
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  • 27
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    Nature biotechnology 24 (2006), S. 1377-1383 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development ...
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    Nature biotechnology 24 (2006), S. 1039-1039 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] No technology embodies the rise of 'omic' science more than the DNA microarray. First reduced to practice in the early 1990s, it has since undergone numerous iterations, adaptations and refinements to achieve its present status as the platform of choice for massively parallel gene expression ...
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    Nature biotechnology 24 (2006), S. 1184-1184 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] One year on from the enforcement of Brazil's innovation law, the first national innovation law in Latin America, it has already earned praise from the country's scientific community, especially from that part dealing with applied research in industry and agriculture, with an emphasis on biotech. ...
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    Nature biotechnology 24 (2006), S. 1188-1188 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] When Michael Fernandez took over as director of the Pew Initiative on Food and Biotechnology (PIFB) in September 2005, his former boss bequeathed to him a lava lamp for his desk. Oddly enough, the lamp had been the prize for a Halloween costume that parodied Fernandez' image as a dapper science ...
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    Nature biotechnology 24 (2006), S. 1199-1200 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To the editor: In their letter of correspondence “Eprex-associated pure red cell aplasia and leachates” in the June issue (Nat. Biotechnol. 24, 613–614, 2006), Schellekens & Jiskoot discuss what they consider to be flaws in Johnson & Johnson's (J&J; New Brunswick, NJ, ...
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    Nature biotechnology 24 (2006), S. 1207-1207 
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    Notes: [Auszug] When a biotech company succeeds, it can find more cash in the bank than needed for research and development. It may decide to buy back, or repurchase, its own shares. A buyback is neither good nor bad by definition, but may be smart, dumb or bordering on fraudulent. To make you a savvier, more ...
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    Nature biotechnology 24 (2006), S. 1474-1475 
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    Notes: [Auszug] To the editor: Determining the functions of genes and proteins is a central problem in biology, fundamental to understanding the molecular and biochemical processes that sustain health or cause disease, to identifying and validating new drug targets and to developing reliable diagnostics. Recent ...
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    Nature biotechnology 24 (2006), S. 1223-1224 
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    Notes: [Auszug] The emergence of systems biology has led to a demand for quantitative, comprehensive data on all aspects of biological phenomena. Some aspects, such as RNA expression and protein structure, have received much attention, while others, such as protein location, have lagged behind. In this issue, ...
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    Nature biotechnology 24 (2006), S. 1227-1229 
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    Notes: [Auszug] The shift toward sustainable production systems has focused attention on bioplastics, which can be produced by many microorganisms from renewable raw materials. Polyhydroxyalkanoates (PHAs) are natural polyesters synthesized in the form of discrete intracellular granules in abundances that can ...
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    Nature biotechnology 24 (2006), S. 1229-1230 
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    Notes: [Auszug] Wastewater treatment around the world relies largely on microbial ecosystems, yet little is known about the organisms involved. This 'black box' system mediates aerobic and anaerobic processes that diminish high phosphate loads in wastewaters, a process known as enhanced biological phosphate ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 24, 841–847 (2006); published online 25 June 2006; corrected after print 25 July 2006 In the print version of this article and the version initially published online, the last sentence of the URLs section in Methods, p.846, reads, “Sequence information regarding the ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 23, 995–1001 (2005), published online 17 July 2005; corrected after print 25 July 2006 In the Methods section, p. 1,000, col. 2, paragraph 2, the text beginning: “The whole plate was discarded if for any time point...” and ending, “The final data set ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 24, 708–712 (2006); published online 21 May 2006; corrected after print 25 July 2006 In the Methods section, p.711, “Library construction and selection,” line 11 of the print version of this article and the version initially published online, the plates used for ...
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    Nature biotechnology 24 (2006), S. 51-53 
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    Notes: [Auszug] How does one model a simple cell-signaling pathway? Consider a simple example consisting of a stimulant, an extracellular signal, an inhibitor of the signal, a G protein–coupled receptor, a G protein and the cellular response. The stimulant induces production of the extracellular signal in ...
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    Nature biotechnology 24 (2006), S. 79-88 
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    Notes: [Auszug] Existing variants of green fluorescent protein (GFP) often misfold when expressed as fusions with other proteins. We have generated a robustly folded version of GFP, called 'superfolder' GFP, that folds well even when fused to poorly folded polypeptides. Compared to 'folding reporter' GFP, a ...
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    Nature biotechnology 24 (2006), S. 100-104 
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    Notes: [Auszug] Bacterial protein secretion is important in the life cycles of most bacteria, in which it contributes to the formation of pili and flagella and makes available extracellular enzymes to digest polymers for nutritional purposes and toxins to kill host cells in infections of humans, animals and ...
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    Nature biotechnology 24 (2006), S. 63-71 
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    Notes: [Auszug] The area devoted to growing transgenic plants expressing insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) is increasing worldwide. A major concern with the adoption of Bt crops is their potential impact on nontarget organisms including biological control organisms. Regulatory ...
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    Nature biotechnology 24 (2006), S. 874-874 
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    Notes: [Auszug] The return of the multiple sclerosis (MS) drug Tysabri (natalizumab) to the US market, sanctioned by the US Food and Drug Administration (FDA) on June 5, and its first-time approval in the EU, announced on June 29, was welcomed by investors. The move should also eventually lead to a clearer ...
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    Nature biotechnology 24 (2006), S. 875-876 
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    Notes: [Auszug] Nuvelo is forging ahead with phase 3 trials on its blood-clot buster enzyme alfimeprase, with results expected early next year. The recombinant enzyme attracted the attention of Bayer Healthcare, which earlier this year signed a $385-million deal for alfimeprase's non-US rights—an ...
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    Nature biotechnology 24 (2006), S. 884-884 
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    Notes: [Auszug] Diagnostics companies have had record fundraising on the public markets over the past few years. Venture capital also expanded last year, raising more than double than in previous years, with $113 million the average quarterly amount raised over the past year compared with only $47 ...
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    Nature biotechnology 24 (2006), S. 885-887 
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    Notes: [Auszug] Even as the science supporting innovation in drug and device development moves forward, the US agency charged with evaluating the products of that science remains embroiled in battles over resources and even its proper mandate. Indeed, the Food and Drug Administration (FDA, Rockville, MD, USA), ...
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    Nature biotechnology 24 (2006), S. 888-890 
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    Notes: [Auszug] Once the province of clinical genetics units in hospitals and clinics, genetic tests have become a commodity. With the click of a mouse, you can order up tests to find out whether you are a carrier of the cystic fibrosis (CF) gene, prone to cardiovascular disease or a member of an ancient tribe. ...
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    Nature biotechnology 24 (2006), S. 1226-1227 
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    Notes: [Auszug] Mass spectrometry (MS) allows the localization of phosphorylated amino acid residues in proteins. Precise annotation of phosphorylation sites is not trivial, however, because of the inherent complexity of most phosphopeptide mass spectra. In this issue, Beausoleil et al. report computational ...
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    Nature biotechnology 24 (2006), S. 899-899 
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    Notes: [Auszug] To the editor: In their commentary in the December issue (Nat. Biotechnol. 23, 1479–1480, 2005) Jon Beckwith and Franklin Huang chastise T. H. Morgan for his failure to make a fuss about eugenics in 1915. That year, he gave the Vanuxem Lectures at Princeton University, which were published ...
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    Nature biotechnology 24 (2006), S. 899-900 
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    Notes: [Auszug] To the editor: An endorsement of ethical responsibility in science is difficult to oppose. The challenge, however, often is to ascertain what constitutes an ethical or wise course of action. In their commentary, Beckwith and Huang allude specifically to a “stirring of the scientific ...
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    Nature biotechnology 24 (2006), S. 900-901 
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    Notes: [Auszug] To the editor: The letter by Katariina Majander et al. in last year's April issue (Nat. Biotechnol. 23, 475–481, 2005) described the use of a modified flagellar type III secretion system (TTSS) to secrete heterologous polypeptides into the growth medium of Escherichia coli. N-terminal ...
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    Nature biotechnology 24 (2006), S. 901-902 
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    Notes: [Auszug] Katariina Majander et al. respond In contrast to the comments of Gál et al., the aim of our paper was not to address the nature of the secretion signal motif per se but to evaluate the biotechnological potential of the secretion system. We did, however, briefly discuss the three proposed ...
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    Nature biotechnology 24 (2006), S. 914-916 
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    Notes: [Auszug] Chromogenic stains have been a mainstay as readouts for immunodiagnostics. 'Brown' staining—also known as diaminobenzidine (DAB) chromogenic staining or immunoperoxidase staining—was adopted very early in anatomic pathology and rapidly became the standard for immunohistochemistry in ...
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    Nature biotechnology 24 (2006), S. 902-903 
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    Notes: [Auszug] To the editor: PubMed is the key retrieval engine for Medline abstracts, and its host, the US National Library of Medicine (NLM; Bethesda, Maryland), provides efficient query interfaces. The result of queries is a list of abstracts, in which the most recent documents appear at the top. If the list ...
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    Nature biotechnology 24 (2006), S. 905-908 
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    Notes: [Auszug] Biomarkers measured in a variety of patient samples, including blood, tissue, urine and cerebrospinal fluid, are used in a diverse array of clinical settings. Although many successful biomarkers have been developed to date, advances in genetics and proteomics promise to usher in a new era of ...
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    Nature biotechnology 24 (2006), S. 927-929 
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    Notes: [Auszug] In vitro diagnostics (IVDs) has been an area of considerable innovation over the past decade, transforming the practice of medicine in the process. In the area of cardiovascular care alone, new markers for early cardiac injury and for heart failure have fundamentally changed the way doctors manage ...
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    Nature biotechnology 24 (2006), S. 930-930 
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    Notes: [Auszug] Although you might have been led to believe there is a 'clear vision' for the molecular diagnostics revolution, in reality the investing picture is much murkier. Revenues haven't produced much profit or free cash flow (and are unlikely to do so anytime soon). And rather than stand-alone diagnostics ...
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    Nature biotechnology 24 (2006), S. 45-46 
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    Notes: [Auszug] Fish have been used as models in cancer research for almost a century because of the strikingly similar histopathological features of fish and human tumors. Despite this agreement, however, very little is known about the correspondence of the molecular mechanisms that drive tumorigenesis in these ...
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    Nature biotechnology 24 (2006), S. 971-983 
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    Notes: [Auszug] Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted therapy and monitor activity and therapeutic response across a wide spectrum of disease. Proteomics methods based on mass spectrometry hold special promise for the discovery of novel biomarkers that might form ...
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    Nature biotechnology 24 (2006), S. 725-725 
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    Notes: [Auszug] The last time biofuels figured prominently on the editorial pages of this journal was July 1996. Back then, we were struck by how many biofuel projects appeared to be “solutions in search of a problem.” Ten years later, a problem has been found. Biofuels, in particular ethanol, are ...
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    Nature biotechnology 24 (2006), S. 727-728 
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    Notes: [Auszug] A flurry of investment activity during the first months of 2006 is evidence that some investors are waking up to the untapped market potential of a range of widely occurring gastrointestinal (GI) conditions that are as yet not well served. Companies, however, face difficult challenges because of ...
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    Nature biotechnology 24 (2006), S. 726-726 
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    Notes: [Auszug] While biotech researchers are stepping up to increase the efficiency and reduce the environmental impact of ethanol production, investors are also doing their bit to get biofuel off the launch pad. No less than Bill Gates, entrepreneur Richard Branson, venture capital guru Vinod Khosla and ...
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    Nature biotechnology 24 (2006), S. 729-729 
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    Notes: [Auszug] Exelixis just presented phase 1 clinical trial data for three new kinase inhibitors at the 2006 American Society of Clinical Oncology annual meeting held in Atlanta, Georgia June 2–3. The compounds are included in a licensing and development deal with GlaxoSmithKline (GSK) that gives the ...
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    Nature biotechnology 24 (2006), S. 730-730 
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    Notes: [Auszug] In May, Merck, one of the oldest and stodgiest pharmaceutical companies, entered the biotech arena by announcing its plans to purchase two protein manufacturing firms: GlycoFi for $400 million and Abmaxis for $80 million. Now that even the most traditional pharmaceutical companies are ...
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    Nature biotechnology 24 (2006), S. 735-735 
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    Notes: [Auszug] Anyone who has spent time with Elliot Entis, CEO and cofounder of Aqua Bounty Technologies (ABT), has heard him say that he subscribes to the “pinball theory of life.” That is, when the right people and the right ideas are bouncing around together, the combination eventually results in ...
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    Nature biotechnology 24 (2006), S. 749-751 
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    Notes: [Auszug] To the editor: In their Perspective on commercialized Bacillus thuringiensis (Bt) toxin transgenic crops and biological control in the January issue (Nat. Biotechnol. 24, 63–71, 2006), Jörg Romeis et al. draws some conclusions that do not fully and accurately represent the published ...
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    Nature biotechnology 24 (2006), S. 751-753 
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    Notes: [Auszug] Jörg Romeis, Michael Meissle and Franz Bigler respond: Our Perspective compiled available peer-reviewed literature addressing the impact on biological control organisms of transgenic crops that express Cry proteins derived from Bacillus thuringiensis (Bt). The published results were discussed ...
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    Nature biotechnology 24 (2006), S. 755-760 
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    Notes: [Auszug] Are biofuels an idea whose time has come? Biotech industry boosters, environmental groups, farmers, automobile manufacturers and even some oil companies say that fuel made from plants, organic waste products and various other forms of biomass is now a feasible proposition. There are even ...
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    Nature biotechnology 24 (2006), S. 753-753 
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    Notes: [Auszug] To the editor: While the debate continues on the appropriate level of regulatory oversight for transgenic plants, we believe there are strong reasons for legislators to differentiate cisgenic from transgenic plants. A cisgenic plant is a crop plant that has been genetically modified with one or ...
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    Nature biotechnology 24 (2006), S. 761-764 
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    Notes: [Auszug] The recent establishment of the Regional Greenhouse Gas Initiative, a carbon cap-and-trade strategy to help curb global warming by nine states in the northeast United States, is significant not only because it sharply contrasts with US federal policy but also because it sends a message, rather than ...
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    Nature biotechnology 24 (2006), S. 765-767 
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    Notes: [Auszug] Plants use the energy of sunlight to fix atmospheric CO2 into a vast biomass, yet we currently use only a small proportion of this fixed carbon for fuel, fiber and building materials. At least three major factors—rapidly increasing atmospheric CO2 levels, dwindling fossil fuel reserves and ...
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    Nature biotechnology 24 (2006), S. 768-768 
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    Notes: [Auszug] Just like you should go for a health checkup every year, you should also periodically check the vital signs of your investments. There are essentially three steps in checking your stock picks and comparing them with passive investments that mimic the well-known market averages. The first is to ...
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    Nature biotechnology 24 (2006), S. 769-776 
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    Notes: [Auszug] The past three years have been interesting times for the biopharmaceutical industry. The first biosimilar product—Omnitrope (recombinant human growth hormone (rhGH); Sandoz, Holzkirchen, Germany) for treating growth hormone deficiencies—was approved in both the United States and Europe; ...
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    Nature biotechnology 24 (2006), S. 777-784 
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    Notes: [Auszug] Biodiesel and ethanol, despite their surging popularity as transportation fuels, barely put a dent in our use of oil. But that could change. The biggest well in biofuels has yet to be tapped—lignocellulose, the woody part of the plant and a potentially abundant source of energy. ...
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    Nature biotechnology 24 (2006), S. 787-787 
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    Notes: [Auszug] Recent patent applications in microarrays ...
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    Nature biotechnology 24 (2006), S. 785-786 
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    Notes: [Auszug] Academics and governmental agencies express concern that the explosive growth in biotech patenting might hamper successful innovation, technology transfer and commercialization of biotechnological advances for society's use. The prospect of a 'patent thicket' or 'anti-commons' is especially serious ...
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    Nature biotechnology 24 (2006), S. 789-790 
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    Notes: [Auszug] Techniques commonly used with fission and budding yeasts, such as genetic analysis and the endogenous tagging of proteins, are often the envy of people working with higher eukaryotes. In this issue, Yoshida and colleagues at the RIKEN Institute in Japan present a long-awaited report on an ORFeome ...
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    Nature biotechnology 24 (2006), S. 791-792 
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    Notes: [Auszug] Although invasive pathogens may express thousands of proteins containing millions of potential epitopes, only a small subset of these sequences actually stimulates immunity. Indeed, accurate prediction of epitopes is akin to finding a needle in a haystack. In this issue, Moutaftsi et al. ...
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    Nature biotechnology 24 (2006), S. 793-794 
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    Notes: [Auszug] In phage display, a protein of interest is incorporated into the coat of a filamentous bacteriophage of Escherichia coli by genetically fusing it with one of several phage coat proteins. However, because the phage coat is assembled in the periplasm, phage display has been limited to the subset of ...
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    Nature biotechnology 24 (2006), S. 794-796 
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    Notes: [Auszug] Protein kinases have proved their mettle as drug targets in oncology. The strategy of “drugging the cancer kinome” has led to trastuzumab (Herceptin), targeted to ERBB2/HER2; imatinib (Gleevec), targeted to BRC-ABL, KIT and PDFGR; and gefitinib/erlotinib (Iressa/Tarceva), targeted to ...
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    Nature biotechnology 24 (2006), S. 796-797 
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    Notes: [Auszug] The enthusiasm surrounding RNA interference (RNAi) as a new therapeutic modality has been tempered by a growing awareness of its potential to cause unwanted side effects. RNAi has been found variously to induce 'off-target' gene silencing, to trigger an interferon response leading to global ...
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    Nature biotechnology 24 (2006), S. 799-799 
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    Notes: [Auszug] Siliconized spider silk What do you get if you cross a cobweb with plankton? The answer is probably something similar to what Kaplan and colleagues have obtained through genetic engineering: hard, crystal-like threads that could be useful in the design and engineering of biomaterials for bone ...
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    Notes: [Auszug] Even proteins that fold well in bacteria are frequently displayed poorly on filamentous phages. Low protein presentation on phage might be caused by premature cytoplasmic folding, leading to inefficient translocation into the periplasm. As translocation is an intermediate step in phage assembly, we ...
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    Notes: [Auszug] The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b ...
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    Nature biotechnology 24 (2006), S. 848-851 
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    Notes: [Auszug] Although optical absorption is strongly associated with the physiological status of biological tissue, existing high-resolution optical imaging modalities, including confocal microscopy, two-photon microscopy and optical coherence tomography, do not sense optical absorption directly. ...
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    Notes: [Auszug] Conventional anti-inflammatory strategies induce multiple side effects, highlighting the need for novel targeted therapies. Here we show that knockdown of the basic-region leucine zipper protein, c-Jun, by a catalytic DNA molecule, Dz13, suppresses vascular permeability and transendothelial ...
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    Nature biotechnology 24 (2006), S. 594-594 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Every year, Nature Biotechnology publishes a financial survey of the public biotech sector (); this year, for the first time, we also analyze the financial health of that other uncharted universe, private biotech firms (). Throughout biotech's history, few have questioned the wisdom of using the ...
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    Nature biotechnology 24 (2006), S. 595-596 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In April, Pfizer bought a Genentech spinoff, Rinat Neuroscience, for “close to $500 million dollars,” according to one source. What drew Pfizer's interest to Rinat was its pipeline, in particular, two of its most advanced drugs. Both are monoclonal antibodies that Pfizer hopes to ...
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    Nature biotechnology 24 (2006), S. 597-597 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first ever clinical trial of a therapeutic that binds to natural killer (NK) cell receptors is slated to take place before the year end. Its goal is to harness directly the therapeutic potential of NK cells in the treatment of a wide range of immune-related conditions, including cancers, ...
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    Nature biotechnology 24 (2006), S. 598-599 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Now that valuations and market performance have plummeted, many biotech companies have little chance at an initial public offering (IPO). Some therefore turn to the old trick of doing a reverse merger, as an attractive financing option. Essentially the acquisition of a public company shell by a ...
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    Nature biotechnology 24 (2006), S. 635-641 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Around 85% of all healthcare and healthcare-related biotech companies are privately owned, and yet relatively little is known about most of them. This is partly because privately owned companies contribute proportionally little to the overall statistics of the sector: they account for less than 50% ...
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    Nature biotechnology 24 (2006), S. 643-651 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Over the past two decades, biotech firms have played an increasingly important role in the research and development of drugs, technologies and tools. In recent years, a lot of attention has been paid to the role of universities in fostering innovation and technology transfer in biotech in the post ...
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    Nature biotechnology 24 (2006), S. 656-656 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recent patent applications relating to peptide therapeutics ...
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    Nature biotechnology 24 (2006), S. 653-655 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The United States Patent and Trademark Office (USPTO) has, to date, granted 41 patents that claim human embryonic stem (hES) cells in their title and front pages. These include patents on culture methods, differentiated cells derived from hES cells and even hES cells per se. By contrast, the ...
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    Nature biotechnology 24 (2006), S. 657-658 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Relatively few bacterial species observed in nature have been grown in pure culture. For the vast majority of bacteria, genome sequencing has been prevented by the inability to obtain cloned populations using standard microbiological techniques. As a result, bacterial genomicists have become ...
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    Nature biotechnology 24 (2006), S. 661-662 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One of the difficulties facing gene therapy is the risk of an immune response against newly introduced transgenes. Although partial success in abrogating such immune responses has been achieved, additional strategies to limit the risk of host-mediated immune rejection will likely be essential. In a ...
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    Nature biotechnology 24 (2006), S. 663-664 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Robust and reproducible methods for deriving adult pluripotent stem cells would have an immense impact on regenerative medicine. Such cells would circumvent the ethical and technical problems associated with embryonic stem (ES) cells, and the possibility of autologous transplantation would avoid ...
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    Nature biotechnology 24 (2006), S. 665-665 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Silence is golden A recent paper in Science describes a new addition to the toolbox of techniques for knocking down gene expression in cultured cells. Mirkin and colleagues study the utility of gold nanoparticles decorated with antisense oligos for silencing a reporter gene in mouse endothelial ...
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    Nature biotechnology 24 (2006), S. 667-672 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The number of software packages for kinetic modeling of biochemical networks continues to grow. Although most packages share a common core of functionality, the specific capabilities and user interfaces of different packages mean that choosing the best package for a given task is not trivial. We ...
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