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  • Chemistry  (18,239)
  • History, 21st Century
  • Wiley-Blackwell  (18,235)
  • Nature Publishing Group (NPG)  (60)
  • American Institute of Physics (AIP)
  • Cell Press
  • 2010-2014  (60)
  • 1985-1989  (8,157)
  • 1965-1969  (10,078)
  • 2010  (60)
  • 1987  (8,157)
  • 1969  (4,882)
  • 1965  (5,196)
Collection
Publisher
Years
  • 2010-2014  (60)
  • 1985-1989  (8,157)
  • 1965-1969  (10,078)
Year
  • 1
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2010 Apr 1;464(7289):664-7. doi: 10.1038/464664a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Data Mining ; Gene Expression Regulation ; Genes/genetics ; Genome, Human/*genetics ; Genomics/history/trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; *Models, Biological ; Molecular Biology/*history ; Neoplasms/genetics/therapy ; RNA, Untranslated/genetics/metabolism ; Sea Urchins/embryology/genetics ; Systems Biology/*trends ; Tumor Suppressor Protein p53/chemistry/genetics/metabolism ; *Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Sep 30;467(7315):499-500. doi: 10.1038/467499b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20881967" target="_blank"〉PubMed〈/a〉
    Keywords: European Union ; Financing, Organized/economics ; Germany ; History, 20th Century ; History, 21st Century ; Internationality ; Politics ; Research Support as Topic/economics/history ; Science/economics/history/*standards/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simmons, John Galbraith -- England -- Nature. 2010 Oct 14;467(7317):S14-5. doi: 10.1038/467S14a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944614" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Blogging ; Congresses as Topic/*history/*trends ; Conservation of Natural Resources/trends ; Germany ; History, 20th Century ; History, 21st Century ; *Nobel Prize ; Nuclear Warfare ; *Research Personnel/history/trends ; Science/*history/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
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    Nature Publishing Group (NPG)
    Publication Date: 2010-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Aug 12;466(7308):808-10. doi: 10.1038/466808a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20703281" target="_blank"〉PubMed〈/a〉
    Keywords: American Recovery and Reinvestment Act/economics ; Biomedical Research/economics/organization & administration/trends ; Budgets/trends ; Comparative Effectiveness Research ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; National Institutes of Health (U.S.)/*economics/*organization & ; administration/trends ; Religion and Science ; Translational Medical Research ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2010-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mastrandrea, Michael D -- England -- Nature. 2010 Aug 19;466(7309):933. doi: 10.1038/466933a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Intergovernmental Panel on Climate Change Working Group II, Stanford University, Stanford, California 94305, USA. mikemas@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20725032" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols ; Climate Change/*history ; History, 20th Century ; History, 21st Century ; Policy Making ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2010-01-22
    Description: In the lowermost layer of the atmosphere-the troposphere-ozone is an important source of the hydroxyl radical, an oxidant that breaks down most pollutants and some greenhouse gases. High concentrations of tropospheric ozone are toxic, however, and have a detrimental effect on human health and ecosystem productivity. Moreover, tropospheric ozone itself acts as an effective greenhouse gas. Much of the present tropospheric ozone burden is a consequence of anthropogenic emissions of ozone precursors resulting in widespread increases in ozone concentrations since the late 1800s. At present, east Asia has the fastest-growing ozone precursor emissions. Much of the springtime east Asian pollution is exported eastwards towards western North America. Despite evidence that the exported Asian pollution produces ozone, no previous study has found a significant increase in free tropospheric ozone concentrations above the western USA since measurements began in the late 1970s. Here we compile springtime ozone measurements from many different platforms across western North America. We show a strong increase in springtime ozone mixing ratios during 1995-2008 and we have some additional evidence that a similar rate of increase in ozone mixing ratio has occurred since 1984. We find that the rate of increase in ozone mixing ratio is greatest when measurements are more heavily influenced by direct transport from Asia. Our result agrees with previous modelling studies, which indicate that global ozone concentrations should be increasing during the early part of the twenty-first century as a result of increasing precursor emissions, especially at northern mid-latitudes, with western North America being particularly sensitive to rising Asian emissions. We suggest that the observed increase in springtime background ozone mixing ratio may hinder the USA's compliance with its ozone air quality standard.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, O R -- Parrish, D D -- Stohl, A -- Trainer, M -- Nedelec, P -- Thouret, V -- Cammas, J P -- Oltmans, S J -- Johnson, B J -- Tarasick, D -- Leblanc, T -- McDermid, I S -- Jaffe, D -- Gao, R -- Stith, J -- Ryerson, T -- Aikin, K -- Campos, T -- Weinheimer, A -- Avery, M A -- England -- Nature. 2010 Jan 21;463(7279):344-8. doi: 10.1038/nature08708.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, Colorado 80309, USA. owen.r.cooper@noaa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090751" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis/chemistry ; Asia ; Atmosphere/*chemistry ; Ecosystem ; Greenhouse Effect ; History, 20th Century ; History, 21st Century ; North America ; Ozone/*analysis/chemical synthesis/chemistry ; Sample Size ; Seasons
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
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    Nature Publishing Group (NPG)
    Publication Date: 2010-06-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clayton, Julie -- England -- Nature. 2010 Jun 24;465(7301):S4-5. doi: 10.1038/nature09220.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20571553" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Disease ; Animals ; Carrier State/epidemiology/immunology/parasitology ; *Chagas Disease/drug therapy/epidemiology/parasitology/transmission ; Chronic Disease/drug therapy/epidemiology ; Clinical Trials as Topic ; History, 16th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Insect Vectors/parasitology ; Latin America/epidemiology/ethnology ; Neglected Diseases/economics ; Nitroimidazoles/pharmacology/therapeutic use ; Trypanocidal Agents/pharmacology/therapeutic use ; Trypanosoma cruzi/immunology/pathogenicity/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Nov 4;468(7320):6. doi: 10.1038/468006a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21048719" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; Famous Persons ; History, 17th Century ; History, 18th Century ; History, 21st Century ; Italy ; *Jupiter ; *Space Flight ; United States ; United States National Aeronautics and Space Administration/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venter, J Craig -- England -- Nature. 2010 Apr 1;464(7289):676-7. doi: 10.1038/464676a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. Craig Venter Institute, La Jolla, California 92121, USA. jcventer@jcvi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360717" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Continental Population Groups/genetics ; Diploidy ; Female ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genetics, Medical/*trends ; Genome, Human/*genetics ; Genomics/economics/history/*trends ; Haploidy ; Haplotypes/genetics ; History, 20th Century ; History, 21st Century ; Human Genome Project/economics/history ; Humans ; Male ; Phenotype ; Precision Medicine/*trends ; Sequence Analysis, DNA/economics/history/instrumentation/methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Nature Publishing Group (NPG)
    Publication Date: 2010-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lok, Corie -- England -- Nature. 2010 Sep 2;467(7311):18-21. doi: 10.1038/467018a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20811430" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Financing, Government/legislation & jurisprudence ; Nanostructures/chemistry ; *Nanotechnology/economics ; *Research Support as Topic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 11
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis -- England -- Nature. 2010 Apr 1;464(7289):674-5. doi: 10.1038/464674a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, Maryland 20892, USA. francis.collins@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360716" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Genetic Predisposition to Disease/genetics ; Genetics, Medical/*trends ; Genome, Human/*genetics ; Genome-Wide Association Study ; Genomics/economics/history/*trends ; Haplotypes/genetics ; History, 20th Century ; History, 21st Century ; Humans ; Precision Medicine/*trends ; Sequence Analysis, DNA/economics/history/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 12
    Publication Date: 2010-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schrope, Mark -- England -- Nature. 2010 Aug 5;466(7307):680-4. doi: 10.1038/466680a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686546" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disasters/*statistics & numerical data ; *Expeditions/trends ; Food Chain ; Geologic Sediments/analysis/chemistry ; History, 21st Century ; Industry/legislation & jurisprudence ; Liability, Legal ; Methane/analysis/metabolism ; Oceans and Seas ; Oxygen/analysis/metabolism ; Petroleum/*adverse effects/*analysis/poisoning ; *Research ; *Research Personnel ; Seawater/analysis/*chemistry ; United States ; United States Government Agencies/legislation & jurisprudence ; Water Microbiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 13
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    Nature Publishing Group (NPG)
    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schrope, Mark -- England -- Nature. 2010 Jul 15;466(7304):304-5. doi: 10.1038/466304a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631769" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disasters/history ; *Ecosystem ; Fisheries/history/statistics & numerical data ; History, 20th Century ; History, 21st Century ; Marine Biology/history/trends ; Mexico ; Oceans and Seas ; Ostreidae ; Petroleum/*analysis/*toxicity ; Population Dynamics ; Research/history/*statistics & numerical data/trends ; Seawater/*chemistry
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 14
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    Nature Publishing Group (NPG)
    Publication Date: 2010-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Briggs, Derek E G -- England -- Nature. 2010 Aug 5;466(7307):706. doi: 10.1038/466706a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology and Geophysics, and the Peabody Museum of Natural History, Yale University, New Haven, Connecticut 06520, USA. derek.briggs@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686564" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; British Columbia ; *Fossils ; Geologic Sediments/analysis/chemistry ; Great Britain ; History, 20th Century ; History, 21st Century ; Paleontology/*history ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 15
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalton, Rex -- England -- Nature. 2010 Jan 7;463(7277):16. doi: 10.1038/463016a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20054370" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Disasters/prevention & control/statistics & numerical data ; Earthquakes/history/*statistics & numerical data ; Floods/history/*statistics & numerical data ; Fresh Water ; History, 15th Century ; History, 18th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; *Risk Management ; Rivers ; Water Movements
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 16
    Publication Date: 2010-02-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Penders, Bart -- Vermeulen, Niki -- Parker, John N -- England -- Nature. 2010 Jan 14;463(7278):157. doi: 10.1038/463157d.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075896" target="_blank"〉PubMed〈/a〉
    Keywords: Government ; History, 20th Century ; History, 21st Century ; *Learning ; Private Sector ; Public Policy ; Science/*history/*methods/trends ; *Search Engine ; Universities
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 17
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Apr 1;464(7289):649-50. doi: 10.1038/464649a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360688" target="_blank"〉PubMed〈/a〉
    Keywords: Data Collection ; Genetic Testing/trends ; Genetics, Medical/*trends ; Genome, Human/*genetics ; Genomics/economics/*history/trends ; Haplotypes/genetics ; History, 20th Century ; History, 21st Century ; Human Genome Project/*history ; Humans ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 18
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gomory, Ralph -- England -- Nature. 2010 Nov 18;468(7322):378. doi: 10.1038/468378a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085164" target="_blank"〉PubMed〈/a〉
    Keywords: Fractals/*history ; France ; History, 20th Century ; History, 21st Century ; Mathematics/history ; Nature ; Poland ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 19
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    Nature Publishing Group (NPG)
    Publication Date: 2010-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalton, Rex -- England -- Nature. 2010 Feb 11;463(7282):724-5. doi: 10.1038/463724a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20148008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; Cryopreservation ; DNA/genetics/isolation & purification ; DNA, Mitochondrial/analysis/genetics ; Denmark ; Emigration and Immigration/*history ; Feces ; Fossils ; Genetics, Medical/history ; Genome, Human/*genetics ; Greenland/ethnology ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Inuits/*ethnology/*history ; Male ; Paleontology/*history ; Phylogeny ; Reproducibility of Results ; Sequence Analysis, DNA ; Siberia/ethnology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 20
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2009 Dec 17;462(7275):948.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20108440" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; History, 20th Century ; History, 21st Century ; Japan ; *Mentors/psychology ; Periodicals as Topic ; *Research Personnel/education/standards
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 21
    Publication Date: 2010-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Munnich, Arnold -- England -- Nature. 2010 Jul 1;466(7302):20. doi: 10.1038/466020a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20595986" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/organization & administration ; Biomedical Research/*economics/*organization & administration/standards ; France ; Genetics, Medical ; History, 20th Century ; History, 21st Century ; Hospitals, University/trends ; Research Support as Topic/organization & administration ; Universities/economics/*organization & administration/standards
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 22
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agre, Peter -- England -- Nature. 2010 Oct 14;467(7317):S11. doi: 10.1038/467S11a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944611" target="_blank"〉PubMed〈/a〉
    Keywords: Aquaporins/metabolism ; Chemistry ; Happiness ; Interdisciplinary Communication ; Mentors ; Neurosciences/trends ; *Nobel Prize ; Peer Review, Research ; Politics ; Public Policy ; Research/standards/trends ; *Research Personnel/psychology/standards
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 23
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agre, Peter -- England -- Nature. 2010 Jan 21;463(7279):281. doi: 10.1038/463281a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090722" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Communication ; Cuba ; Democratic People's Republic of Korea ; History, 21st Century ; *International Cooperation ; International Educational Exchange ; Politics ; *Science/economics/trends ; United States
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  • 24
    Publication Date: 2010-09-17
    Description: Every winter, the high-latitude oceans are struck by severe storms that are considerably smaller than the weather-dominating synoptic depressions. Accompanied by strong winds and heavy precipitation, these often explosively developing mesoscale cyclones-termed polar lows-constitute a threat to offshore activities such as shipping or oil and gas exploitation. Yet owing to their small scale, polar lows are poorly represented in the observational and global reanalysis data often used for climatological investigations of atmospheric features and cannot be assessed in coarse-resolution global simulations of possible future climates. Here we show that in a future anthropogenically warmed climate, the frequency of polar lows is projected to decline. We used a series of regional climate model simulations to downscale a set of global climate change scenarios from the Intergovernmental Panel of Climate Change. In this process, we first simulated the formation of polar low systems in the North Atlantic and then counted the individual cases. A previous study using NCEP/NCAR re-analysis data revealed that polar low frequency from 1948 to 2005 did not systematically change. Now, in projections for the end of the twenty-first century, we found a significantly lower number of polar lows and a northward shift of their mean genesis region in response to elevated atmospheric greenhouse gas concentration. This change can be related to changes in the North Atlantic sea surface temperature and mid-troposphere temperature; the latter is found to rise faster than the former so that the resulting stability is increased, hindering the formation or intensification of polar lows. Our results provide a rare example of a climate change effect in which a type of extreme weather is likely to decrease, rather than increase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zahn, Matthias -- von Storch, Hans -- England -- Nature. 2010 Sep 16;467(7313):309-12. doi: 10.1038/nature09388.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environmental Systems Science Centre, University of Reading, 3 Earley Gate, Reading, Berkshire RG6 6AL, UK. matthias.zahn@gkss.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844533" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Atmosphere/chemistry ; Cyclonic Storms/*statistics & numerical data ; Global Warming/*statistics & numerical data ; Greenhouse Effect ; History, 20th Century ; History, 21st Century ; Models, Theoretical ; Seasons ; Seawater ; Temperature
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  • 25
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nordling, Linda -- England -- Nature. 2010 Nov 4;468(7320):17. doi: 10.1038/468017a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21048736" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Archives ; Astronomy/history ; Data Collection/*methods/*trends ; Databases, Factual/history/trends ; History, 20th Century ; History, 21st Century ; Information Storage and Retrieval/methods/trends ; Museums ; *Research/history ; *Research Personnel ; Temperature
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  • 26
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    Nature Publishing Group (NPG)
    Publication Date: 2010-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farley, Donald T -- England -- Nature. 2010 Mar 25;464(7288):502. doi: 10.1038/464502a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20336130" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/*history ; Atmosphere/analysis ; Engineering/*history ; Extraterrestrial Environment ; History, 20th Century ; History, 21st Century ; New York ; Puerto Rico ; Radar/history/instrumentation ; Radio
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  • 27
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapman, Henry N -- England -- Nature. 2010 Sep 23;467(7314):409-10. doi: 10.1038/467409a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864990" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/*cytology/*radiography ; Female ; History, 19th Century ; History, 21st Century ; Humans ; Imaging, Three-Dimensional/*methods ; Mice ; Microscopy/history/*methods ; Nanotechnology/*methods ; Tomography, X-Ray Computed/*methods
    Print ISSN: 0028-0836
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 28
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    Nature Publishing Group (NPG)
    Publication Date: 2010-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sarewitz, Daniel -- England -- Nature. 2010 Feb 4;463(7281):607. doi: 10.1038/463607a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Consortium for Science, Policy and Outcomes at Arizona State University, USA. dsarewitz@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20130627" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/history ; *Acquired Immunodeficiency Syndrome/drug therapy/history/prevention & control ; *Conservation of Energy Resources/methods/trends ; Energy-Generating Resources ; Global Warming/prevention & control ; History, 20th Century ; History, 21st Century ; Humans ; Zidovudine/history/therapeutic use
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  • 29
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tollefson, Jeff -- England -- Nature. 2010 Oct 21;467(7318):902-5. doi: 10.1038/467902a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20962820" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/analysis/history/prevention & control ; Chlorofluorocarbons/analysis/history ; Cities/epidemiology/history/*statistics & numerical data ; *City Planning/trends ; Climate Change/history/statistics & numerical data ; Conservation of Natural Resources/*trends ; Ecology/*trends ; Environmental Monitoring ; Epidemiological Monitoring ; History, 20th Century ; History, 21st Century ; Humans ; Mexico ; Nobel Prize ; Ozone/analysis/history ; Public Policy/trends ; Smog/analysis/prevention & control
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    Electronic ISSN: 1476-4687
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  • 30
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crutzen, Paul J -- England -- Nature. 2010 Oct 14;467(7317):S10. doi: 10.1038/467S10a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944610" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; Chemistry ; Human Activities ; Interdisciplinary Communication ; Mentors ; *Nobel Prize ; Ozone/analysis ; Politics ; Public Opinion ; Public Policy ; *Research Personnel
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 31
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-12
    Description: How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current unsatisfactory outcomes may change as we approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Insel, Thomas R -- England -- Nature. 2010 Nov 11;468(7321):187-93. doi: 10.1038/nature09552.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Mental Health, Bethesda, Maryland 20892, USA. tinsel@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21068826" target="_blank"〉PubMed〈/a〉
    Keywords: Cognition Disorders/complications/prevention & control/therapy ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; *Models, Neurological ; Schizophrenia/genetics/history/*physiopathology/therapy ; Schizophrenic Psychology
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  • 32
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Nov 11;468(7321):134. doi: 10.1038/468134a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21068784" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/history/legislation & jurisprudence ; Genetic Predisposition to Disease/genetics ; Genetic Privacy/legislation & jurisprudence ; Genetic Testing/ethics/*legislation & jurisprudence ; Genetics, Medical/ethics/*legislation & jurisprudence/standards/*trends ; Genomics/ethics ; Germany ; History, 17th Century ; History, 20th Century ; History, 21st Century ; Humans ; Infant, Newborn ; Neonatal Screening ; Practice Guidelines as Topic
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  • 33
    Publication Date: 2010-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gann, Alexander -- Witkowski, Jan -- England -- Nature. 2010 Sep 30;467(7315):519-24. doi: 10.1038/467519a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 11724, USA. ganna@cshl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20881989" target="_blank"〉PubMed〈/a〉
    Keywords: *Correspondence as Topic/history ; DNA/chemistry/*history ; Great Britain ; History, 20th Century ; History, 21st Century ; Nucleic Acid Conformation ; Research Personnel/*history
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  • 34
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    Nature Publishing Group (NPG)
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Sep 23;467(7314):367. doi: 10.1038/467367a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864949" target="_blank"〉PubMed〈/a〉
    Keywords: Disasters ; Faculty ; Federal Government/history ; Floods ; History, 21st Century ; *International Cooperation ; Investments/*economics/history ; Pakistan ; Research Support as Topic/economics/history ; Salaries and Fringe Benefits/economics ; Universities/*economics/history/trends
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  • 35
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, Robert -- England -- Nature. 2010 Apr 1;464(7289):678. doi: 10.1038/464678a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA. weinberg@wi.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360718" target="_blank"〉PubMed〈/a〉
    Keywords: Genome, Human/genetics ; Genomics/economics/trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/economics ; Humans ; *Models, Biological ; Neoplasms/diagnosis/drug therapy/*genetics/pathology ; Signal Transduction ; Systems Biology/economics/*trends
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  • 36
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Jan 21;463(7279):269-70. doi: 10.1038/463269b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090703" target="_blank"〉PubMed〈/a〉
    Keywords: Bioengineering/history/*trends ; Biology/history/*trends ; Congresses as Topic ; History, 21st Century
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  • 37
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brumfiel, Geoff -- Inman, Mason -- England -- Nature. 2010 Sep 23;467(7314):378-9. doi: 10.1038/467378a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864966" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; History, 21st Century ; Investments/economics/history/*statistics & numerical data/trends ; Pakistan ; Plagiarism ; Research Personnel/economics ; Research Support as Topic/economics/history/statistics & numerical data/trends ; Uncertainty ; Universities/*economics/history/standards/trends
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  • 38
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2010 Oct 7;467(7316):641-2. doi: 10.1038/467641a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20930811" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; *Fertilization in Vitro/ethics/history ; Great Britain ; History, 20th Century ; History, 21st Century ; Humans ; Male ; *Nobel Prize
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  • 39
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    Nature Publishing Group (NPG)
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- England -- Nature. 2010 Jun 10;465(7299):673. doi: 10.1038/465673a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535171" target="_blank"〉PubMed〈/a〉
    Keywords: American Recovery and Reinvestment Act ; Budgets ; Engineering ; History, 20th Century ; History, 21st Century ; India/ethnology ; Politics ; United States ; United States Government Agencies/economics/*organization & administration
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  • 40
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    Nature Publishing Group (NPG)
    Publication Date: 2010-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cressey, Daniel -- England -- Nature. 2010 Aug 5;466(7307):675. doi: 10.1038/466675b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686542" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/*organization & administration ; Great Britain ; History, 21st Century ; Research Support as Topic/economics/organization & administration/trends
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  • 41
    Publication Date: 2010-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cressey, Daniel -- England -- Nature. 2010 Jan 28;463(7280):422-3. doi: 10.1038/463422a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20110964" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/genetics/therapy ; Female ; Genetic Testing/history ; History, 20th Century ; History, 21st Century ; Humans ; *Translational Medical Research/history
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  • 42
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kwok, Roberta -- England -- Nature. 2010 Nov 4;468(7320):22-5. doi: 10.1038/468022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21048740" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/history ; Genome, Bacterial/genetics ; *Genomics/history/trends ; Haemophilus influenzae/genetics ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; Molecular Biology/history/trends ; Mycoplasma genitalium/genetics ; Mycoplasma mycoides/genetics ; *Synthetic Biology/history/trends
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  • 43
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adam, David -- England -- Nature. 2010 Nov 18;468(7322):362-4. doi: 10.1038/468362a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085150" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Anniversaries and Special Events ; *Climate Change ; *Electronic Mail ; Ethics, Research ; Great Britain ; History, 21st Century ; Mass Media ; Reproducibility of Results ; *Research Personnel/ethics/psychology ; Temperature
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  • 44
    Publication Date: 2010-07-09
    Description: The Sahara Desert is the largest source of mineral dust in the world. Emissions of African dust increased sharply in the early 1970s (ref. 2), a change that has been attributed mainly to drought in the Sahara/Sahel region caused by changes in the global distribution of sea surface temperature. The human contribution to land degradation and dust mobilization in this region remains poorly understood, owing to the paucity of data that would allow the identification of long-term trends in desertification. Direct measurements of airborne African dust concentrations only became available in the mid-1960s from a station on Barbados and subsequently from satellite imagery since the late 1970s: they do not cover the onset of commercial agriculture in the Sahel region approximately 170 years ago. Here we construct a 3,200-year record of dust deposition off northwest Africa by investigating the chemistry and grain-size distribution of terrigenous sediments deposited at a marine site located directly under the West African dust plume. With the help of our dust record and a proxy record for West African precipitation we find that, on the century scale, dust deposition is related to precipitation in tropical West Africa until the seventeenth century. At the beginning of the nineteenth century, a sharp increase in dust deposition parallels the advent of commercial agriculture in the Sahel region. Our findings suggest that human-induced dust emissions from the Sahel region have contributed to the atmospheric dust load for about 200 years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mulitza, Stefan -- Heslop, David -- Pittauerova, Daniela -- Fischer, Helmut W -- Meyer, Inka -- Stuut, Jan-Berend -- Zabel, Matthias -- Mollenhauer, Gesine -- Collins, James A -- Kuhnert, Henning -- Schulz, Michael -- England -- Nature. 2010 Jul 8;466(7303):226-8. doi: 10.1038/nature09213.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MARUM-Center for Marine Environmental Sciences, University of Bremen, Leobener Strasse, D-28359 Bremen, Germany. smulitza@uni-bremen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20613839" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western ; Agriculture/*history ; Arachis/growth & development ; Atmosphere/chemistry ; Barbados ; Desert Climate ; Dust/*analysis ; Fresh Water/chemistry ; Geologic Sediments/chemistry ; Gossypium/growth & development ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Particle Size ; Rain ; Seawater ; Tropical Climate ; Wind
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  • 45
    Publication Date: 2010-10-12
    Description: More than half of the solar energy absorbed by land surfaces is currently used to evaporate water. Climate change is expected to intensify the hydrological cycle and to alter evapotranspiration, with implications for ecosystem services and feedback to regional and global climate. Evapotranspiration changes may already be under way, but direct observational constraints are lacking at the global scale. Until such evidence is available, changes in the water cycle on land-a key diagnostic criterion of the effects of climate change and variability-remain uncertain. Here we provide a data-driven estimate of global land evapotranspiration from 1982 to 2008, compiled using a global monitoring network, meteorological and remote-sensing observations, and a machine-learning algorithm. In addition, we have assessed evapotranspiration variations over the same time period using an ensemble of process-based land-surface models. Our results suggest that global annual evapotranspiration increased on average by 7.1 +/- 1.0 millimetres per year per decade from 1982 to 1997. After that, coincident with the last major El Nino event in 1998, the global evapotranspiration increase seems to have ceased until 2008. This change was driven primarily by moisture limitation in the Southern Hemisphere, particularly Africa and Australia. In these regions, microwave satellite observations indicate that soil moisture decreased from 1998 to 2008. Hence, increasing soil-moisture limitations on evapotranspiration largely explain the recent decline of the global land-evapotranspiration trend. Whether the changing behaviour of evapotranspiration is representative of natural climate variability or reflects a more permanent reorganization of the land water cycle is a key question for earth system science.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jung, Martin -- Reichstein, Markus -- Ciais, Philippe -- Seneviratne, Sonia I -- Sheffield, Justin -- Goulden, Michael L -- Bonan, Gordon -- Cescatti, Alessandro -- Chen, Jiquan -- de Jeu, Richard -- Dolman, A Johannes -- Eugster, Werner -- Gerten, Dieter -- Gianelle, Damiano -- Gobron, Nadine -- Heinke, Jens -- Kimball, John -- Law, Beverly E -- Montagnani, Leonardo -- Mu, Qiaozhen -- Mueller, Brigitte -- Oleson, Keith -- Papale, Dario -- Richardson, Andrew D -- Roupsard, Olivier -- Running, Steve -- Tomelleri, Enrico -- Viovy, Nicolas -- Weber, Ulrich -- Williams, Christopher -- Wood, Eric -- Zaehle, Sonke -- Zhang, Ke -- England -- Nature. 2010 Oct 21;467(7318):951-4. doi: 10.1038/nature09396.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Biogeochemistry, 07745 Jena, Germany. mjung@bgc-jena.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20935626" target="_blank"〉PubMed〈/a〉
    Keywords: Artificial Intelligence ; Atmosphere/*chemistry ; Fresh Water/*analysis ; *Global Warming/statistics & numerical data ; History, 20th Century ; History, 21st Century ; Humidity ; Plant Transpiration/*physiology ; Reproducibility of Results ; Seasons ; Soil/analysis ; Uncertainty ; Volatilization ; *Water Cycle
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  • 46
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Ommen, Gertjan -- England -- Nature. 2010 Apr 15;464(7291):992. doi: 10.1038/464992a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393553" target="_blank"〉PubMed〈/a〉
    Keywords: Finland ; Genetics, Medical/*history ; History, 20th Century ; History, 21st Century ; Humans ; Twin Studies as Topic/history
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  • 47
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    Nature Publishing Group (NPG)
    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Jul 15;466(7304):295. doi: 10.1038/466295a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631753" target="_blank"〉PubMed〈/a〉
    Keywords: Biofuels/supply & distribution ; Biotechnology/*history/*trends ; Brazil ; Genome, Bacterial/genetics ; Genomics/*history ; History, 20th Century ; History, 21st Century ; Humans ; Internationality ; Saccharum/genetics/metabolism ; Xylella/genetics
    Print ISSN: 0028-0836
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  • 48
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    Nature Publishing Group (NPG)
    Publication Date: 2010-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maher, Brendan -- England -- Nature. 2010 Jan 14;463(7278):150-2. doi: 10.1038/463150a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075894" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Centers for Disease Control and Prevention (U.S.)/organization & ; administration/standards ; *Communication ; *Health Education/methods/standards ; History, 20th Century ; History, 21st Century ; Humans ; Influenza A Virus, H1N1 Subtype/pathogenicity ; Influenza Vaccines/supply & distribution ; Influenza, Human/*epidemiology/prevention & control/psychology/virology ; Internationality ; Mexico/epidemiology ; Public Health/*methods/*standards ; Uncertainty ; United States ; World Health Organization
    Print ISSN: 0028-0836
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  • 49
    Publication Date: 2010-07-03
    Description: Global climate and the atmospheric partial pressure of carbon dioxide () are correlated over recent glacial cycles, with lower during ice ages, but the causes of the changes are unknown. The modern Southern Ocean releases deeply sequestered CO(2) to the atmosphere. Growing evidence suggests that the Southern Ocean CO(2) 'leak' was stemmed during ice ages, increasing ocean CO(2) storage. Such a change would also have made the global ocean more alkaline, driving additional ocean CO(2) uptake. This explanation for lower ice-age , if correct, has much to teach us about the controls on current ocean processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sigman, Daniel M -- Hain, Mathis P -- Haug, Gerald H -- England -- Nature. 2010 Jul 1;466(7302):47-55. doi: 10.1038/nature09149.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geosciences, Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA. sigman@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20596012" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Atmosphere/*chemistry ; Carbon Dioxide/*analysis/*history/metabolism ; Eukaryota/metabolism ; History, 21st Century ; History, Ancient ; Hydrogen-Ion Concentration ; *Ice Cover ; Oceans and Seas ; Seawater/*chemistry/microbiology
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  • 50
    Publication Date: 2010-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bown, William Cullerne -- England -- Nature. 2010 Aug 5;466(7307):689. doi: 10.1038/466689a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686550" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; Great Britain ; History, 20th Century ; History, 21st Century ; Research Support as Topic/history/*legislation & jurisprudence ; Universities/economics
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  • 51
    Publication Date: 2010-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waaijer, Cathelijn J F -- van Bochove, Cornelis A -- van Eck, Nees Jan -- England -- Nature. 2010 Jan 14;463(7278):157. doi: 10.1038/463157a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075899" target="_blank"〉PubMed〈/a〉
    Keywords: History, 21st Century ; Periodicals as Topic/*history ; Politics ; Publishing/*history ; Science/*history
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  • 52
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Apr 1;464(7289):670-1. doi: 10.1038/464670a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360711" target="_blank"〉PubMed〈/a〉
    Keywords: Archives ; Databases, Genetic/history/*statistics & numerical data/trends ; Female ; Genome, Human/*genetics ; Genomics/economics/history/methods/*trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/economics/history ; Humans ; Male ; Sequence Analysis, DNA/economics/history/methods
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  • 53
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    Nature Publishing Group (NPG)
    Publication Date: 2010-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kroto, Harold W -- England -- Nature. 2010 Oct 14;467(7317):S13. doi: 10.1038/467S13a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944613" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Conservation of Energy Resources/methods ; Freedom ; Interdisciplinary Communication ; *Nobel Prize ; Nuclear Fission ; Peer Review, Research ; Private Sector/economics ; Public Opinion ; Research/economics/education ; *Research Personnel/economics/education ; Research Support as Topic/economics/methods
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  • 54
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    Nature Publishing Group (NPG)
    Publication Date: 2010-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stafford, Ned -- England -- Nature. 2010 Dec 23;468(7327):S16-7. doi: 10.1038/468S16a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21179078" target="_blank"〉PubMed〈/a〉
    Keywords: Diet ; *Food ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; History, Medieval ; Humans ; Micronutrients ; Nutrigenomics ; Nutrition Disorders ; Nutritional Sciences/*history/*trends
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  • 55
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    Nature Publishing Group (NPG)
    Publication Date: 2010-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vance, Erik -- England -- Nature. 2010 Nov 18;468(7322):365-6. doi: 10.1038/468365a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085151" target="_blank"〉PubMed〈/a〉
    Keywords: Famous Persons ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Literature, Modern/history ; Male ; *Mass Media ; *Public Relations ; *Research Personnel/psychology/standards ; Sleep/physiology ; *Sleep Medicine Specialty/history ; United States
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  • 56
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    Nature Publishing Group (NPG)
    Publication Date: 2010-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vance, Erik -- England -- Nature. 2010 Jul 1;466(7302):22-3. doi: 10.1038/466022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20595988" target="_blank"〉PubMed〈/a〉
    Keywords: Evidence-Based Emergency Medicine ; History, 21st Century ; Humans ; Male ; *Research ; *Research Personnel/education ; Wilderness ; *Wilderness Medicine/education/manpower
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  • 57
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    Nature Publishing Group (NPG)
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2010 Apr 1;464(7289):668-9. doi: 10.1038/464668a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360710" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computational Biology/economics/history/trends ; Epigenesis, Genetic ; Genome, Human/*genetics ; Genomics/*history/standards/trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/*history ; Humans ; Metagenome ; Patents as Topic/history ; RNA Interference
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  • 58
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    Nature Publishing Group (NPG)
    Publication Date: 2010-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dolgin, Elie -- England -- Nature. 2010 Dec 2;468(7324):620-3. doi: 10.1038/468620a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124428" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics/legislation & jurisprudence/*organization & ; administration ; California ; Diabetes Mellitus, Type 1/therapy ; Embryonic Stem Cells ; Financing, Organized/economics/legislation & jurisprudence/organization & ; administration ; History, 21st Century ; Humans ; Male ; *Patient Advocacy ; Regenerative Medicine/economics/legislation & jurisprudence/*organization & ; administration ; *Stem Cell Research/economics/legislation & jurisprudence
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  • 59
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCray, Patrick -- England -- Nature. 2010 Sep 16;467(7313):271. doi: 10.1038/467271c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844516" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; History, 21st Century ; Imagination ; Nanotechnology/economics/*history/manpower ; Policy Making ; Public Opinion/*history ; Research Support as Topic/history ; United States
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  • 60
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    Nature Publishing Group (NPG)
    Publication Date: 2010-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Roff -- England -- Nature. 2010 May 6;465(7294):24-5. doi: 10.1038/465024a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20445603" target="_blank"〉PubMed〈/a〉
    Keywords: *Earthquakes/history ; Geology/history/instrumentation/*methods/*trends ; History, 20th Century ; History, 21st Century ; Humans
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  • 61
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 150 (1987), S. 189-192 
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A morphological study was made to examine the friction and wear mechanisms of ultrahigh molecular weight polyethylene in air and water by means of transmission electron microscopy of a carbon replica film of a very thin layer of the polymer surface slid against a steel ball. Electron diffractions revealed that a molecular orientation with a typical fiber pattern was formed in the friction in air, while thin ribbon-like crystals with particular crystal orientations were formed in water in a way that the sliding took place on the crystallographic a - c plane, giving rise to a low friction coefficient of the polymer.
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  • 62
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 150 (1987), S. 137-150 
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es wurde der relative Wirkungsgrad von fünf handelsüblichen Stabilisatoren bei Photooxidation und thermischer Alterung von Polypropylen (PP) anhand der Änderungen der mechanischen Eigenschaften untersucht. Es wurden Polypropylenproben mit unterschiedlichem Anteil an Cyasorb UV-531 hergestellt (bezeichnet als PC0.5-31, PC1-31, PC1.5-31 und PC2-31). Der Einfluß der Photooxidation auf das thermische Verhalten ist mit Hilfe der Differentialscanningkalorimetrie und durch thermogravimetrische Analysen untersucht worden. 2-Hydroxy-4-n-octyloxybenzophenon (2 Gew.-%) war am wirksamsten, Polypropylen, gegen Verfärbung und Brüchigkeit zu stabilisieren. Bei einer Probe mit 1% Stabilisatorzusatz fanden sich nach 32 h Bestrahlung noch 81% des ursprünglichen Wertes der Streckgrenze gegenüber 18% bei unstabilisiertem PP.
    Notes: The relative effectiveness of five commercially available stabilizers on the photooxidation and thermal ageing of polypropylene (PP) was investigated by following changes in mechanical properties. Samples of PP containing different percentages of Cyasorb UV-531 were prepared (designated as PC0.5-31, PC1-31, PC1.5-31, and PC2-31, respectively). The effect of photooxidation on thermal behaviour was investigated by differential scanning calorimetry and thermogravimetric analysis. 2-Hydroxy-4-n-octyloxy benzophenone (2% w/w) was most effective in stabilizing PP towards discolouration and brittleness. After 32 h irradiation, 81% retention in yield strength was observed in case of PC1-31 against 18% in case of PP.
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  • 63
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 153 (1987), S. 113-124 
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Käufliche Weizenmehlstärke wurde unter Verwendung verschiedener Mengen Schwefelkohlenstoff und Acrylnitril xanthogeniert und cyanethyliert und dann zur Herstellung von modifizierten Stärke-Naturkautschuk-Masterbatches eingesetzt. Weiterhin wurden die Einflüsse untersucht, die die Gleichgewichte der Xanthogenierung und Cyanethylierung gegenseitig aufeinander ausüben. Die Ergebnisse werden auf der Basis definierter Wechselwirkungen zwischen der Xanthogenatgruppe und dem freien Acrylnitril erklärt. Hierbei führen sowohl sterische Faktoren als auch die höhere Elektrophilie des Acrylnitrils zum Zerfall der Xanthogenatgruppe. Daher kann die Cyanethylierung nur noch in einem geringeren Ausmaß erfolgen.
    Notes: Common wheat flour starch was subjected to xanthation followed by cyanoethylation at various levels of carbon disulfide and acrylonitrile to prepare modified starchnatural rubber masterbatches. Mutual influences of the extents of equilibrium xanthation and cyanoethylation on each other have been studied. The results have been explained on the basis of a definite interaction between xanthate group and free acrylonitrile in which both the steric factors and higher electrophilicity of acrylonitrile lead to the decomposition of xanthate groups and reduced the extent of cyanoethylation.
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  • 64
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Aus Polychloropren und Polyvinylchlorid wurden Blends in verschiedenen Zusammensetzungen hergestellt und ihre Eigenschaften bestimmt. Die Eigenschaften der Blends zeigen, daß sie Polychloropren in vielen Anwendungen ersetzen können.
    Notes: Blends of polychloroprene rubber and plasticized polyvinylchloride have been prepared in various compositions and their properties evaluated. The properties of the blends show that they can be used to replace polychloroprene in many applications.
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  • 65
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The present paper describes a rheo-optical apparatus consisting of an elongational rheometer (with rotary clamps) and a device to measure birefringence. This equipment was designed to perform homogeneous deformations on polymer melts in the simple elongational mode. Elongational experiments were performed on polyisobutylene samples at room temperature using different strain rates (from \documentclass{article}\pagestyle{empty}\begin{document}$\dot \varepsilon$\end{document} 0.01 s-1 to 1 s-1). In typical experiments homogeneous elongations up to λ ≈ 200 and stresses up to 2 · 106 Pa were achieved. The stress, the birefringence, and the deformation were obtained by measuring the force, the sample thickness, the optical retardation (the frequency of the sampling was 20 Hz) and the width of the sample (the frequency of the sampling was 3 Hz). It was found that the stress-optical coefficient was constant. The homogeneity of the deformations was carefully controlled because inhomogeneities cause serious errors in the measurements of elongational viscosity and birefringence.
    Notes: Es wird über eine rheo-optische Apparatur zur Verstreckung von Polymerschmelzen mit rotierenden Klemmen berichtet, die mit einer Doppelbrechungs-Meßeinrichtung ausgerüstet ist. Mit dieser Einrichtung können einfache Dehnungen an Polymerschmelzen bis zu hohen Verstreckgraden unter homogenen Bedingungen durchgeführt werden. Während des Deformationsvorganges können die Spannung, die Doppelbrechung und die Probendicke mit einer Meßrate von 20 Hz, sowie die Probenbreite mit ca. 3 Hz erfaßt werden.Wir haben Messungen an Polyisobutylen bei Raumtemperatur mit verschiedenen Dehngeschwindigkeiten (0,01 s-1 〈 \documentclass{article}\pagestyle{empty}\begin{document}$\dot \varepsilon$\end{document} 〈 1 s-1) bis zu einem Verstreckgrad von λ ≈ 200 durchgeführt. Dabei wurden Spannungen bis zu 2 · 106 Pa erhalten. Das spannungsoptische Gesetz war bei homogener Versuchsführung stets erfüllt. Es wird gezeigt, daß ohne Kontrolle der Dehngeschwindigkeit und insbesondere bei inhomogener Dehung nicht nur Abweichungen vom spannungsoptischen Gesetz, sondern auch große Fehler bei der Spannungs- bzw. Viskositätsberechnung auftreten. Deshalb wurde großer Wert auf die Prüfung der Homogenität der Dehnung gelegt.
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  • 66
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 153 (1987), S. 187-195 
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The miscibility of various polymethylmethacrylate (PMMA)/polybutylmethacrylate (PBMA)/poly(methylmethacrylate-co-butylmethacrylate)systems has been studied. PMMA and PBMA are immiscible. Methacrylic homopolymers and copolymers are immiscible, too. A one-phase mixture from PMMA and PBMA is only accessible by copolymerization.
    Notes: Die Mischbarkeit von verschiedenen Systemen aus Polymethylmethacrylat (PMMA), Polybutylmethacrylat (PBMA) und Poly(methylmethacrylat-co-butylmethacrylat) (P(MMA-co-BMA)) wurde untersucht. PMMA und PBMA sind miteinander nicht mischbar. Die untersuchten Homopolymeren und entsprechende Methacrylatcopolymere bilden ebenfalls heterogene Systeme. Einphasige Mischungen aus PMMA und PBMA sind nur über Copolymerisation erreichbar.
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  • 67
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Mit Hilfe der 13C-NMR-Spektroskopie wurde die Entwicklung der Oligomerenverteilung während der Polymerisation von 13C-angereichertem Ethylen mit dem löslichen Ziegler-Katalysatorsystem Cp2TiMeCl/AlMe2Cl verfolgt. Zuordnung und quantitative Auswertung aller Signale der verschiedenen wachsenden Ketten werden beschrieben. Die Geschwindigkeiten der Ethylen- und der Cp2 TiMeCl-Abnahme sowie die Bildungsgeschwindigkeit neuer Ketten konnten direkt aus den Spektren ermittelt werden. So läßt sich zum ersten Mal zeigen, daß die Konzentration der Ti-Propyl-und Ti-Pentylspezies in einen stationthen Zustand einlaufen. Dies ermbglicht, die Geschwindigkeitskonstanten der Ethyleninsertion in die Ti-Kohlenstoffbindung von Ti-Me, Ti-Pr und Ti-Pe zu ermitteln. Diese Ergebnisse fiihren zu einem detaillierten Ein-blick in den Ablauf der ersten Insertionsschritte und sind so eine Grundlage fur die mathematische Modellierung. Sie sind aufierdem ein weiterer unabhlngiger Beweis für die Giiltigkeit des dynamischen Modells des Mechanismus der Ethylenpolymerisation mit lbslichen Ziegler-Katalysatoren, nlmlich die Bildung der polymerisationsaktiven Spezies in zwei aufeinanderfolgenden sehr dynamischen Gleichgewichtsreaktionen.
    Notes: The development of the oligomer distribution during the polymerization of 13C-enriched ethylene by the soluble Ziegler catalyst system Cp2 TiMeCl/AlMe2Cl was followed by 13C-NMR spectroscopy. The assignment of the signals from the growing chains is described in full. It is shown that the rate of consumption of ethylene and Cp2 TiMeCl and the rate of formation of new chains can be monitored directly from the spectra. The concentrations of Ti-propyl and Ti-pentyl species during the polymerization were followed spectroscopically; both attain a steady state concentration. The relative rates were determined for the insertion of ethylene in the Ti-carbon bond of Ti-Me, Ti-Pr and Ti-Pe. These results give a detailed insight into the way that the oligomer distribution develops and provide a basis for its computer simulation. They also provide an independent proof that the dynamic model for the mechanism of ethylene polymerization with soluble Ziegler catalysts of the type Cp2 TiRCl/AlRnClm is correct.
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  • 68
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    Angewandte Makromolekulare Chemie 154 (1987), S. 99-110 
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Der Einfluß verschiedener Reaktionsbedingungen auf die Bromierung von ataktischem Poly(propylen) (APP) in Tetrachlorkohlenstofflösung wurde untersucht. Mit zunehmender Reaktionszeit steigt der Bromierungsgrad. Auch mit steigender Verdünnung der APP-Lösung nimmt die Bromierungsgeschwindigkeit zu, welche bezüglich der APP-Konzentration die Ordnung 0,66 hat. Dies wird erklärt durch die anfängliche Substitution eines Wasserstoffs am tertiären Kohlenstoffatom. Die folgende H-Abstraktion an den benachbaren sekundären und primären Kohlenstoffatomen ist erleichtert. Die scheinbare Aktivierungsenergie wurde zu 11,9 kcal/mol bestimmt. Die Bromierungsgeschwindigkeit steigt bis zu einem APP : Br2-Molverhältnis von 1 : 1 an, darüber hinaus wird die Geschwindigkeit unabhängig vom Molverhältnis. Die Bromierung scheint folgendermaßen zu verlaufen: Nach anfänglicher Substitution eines tertiären H-Atoms durch freie Bromradikale werden nach und nach auchdie sekundäen und primären H-Atome durch weitergehende Substitution oder durch Addition nach einem Eliminierungsschritt ersetzt. Das IR-Spektrum bestätigt die Anwesenheit von Brom in den Proben.
    Notes: Effects of various reaction conditions on bromination of atactic poly(propylene) (APP) in carbon tetrachloride solution were studied. It was found that with the increase of the reaction time the extent of bromination increases. Also with an increased dilution of APP the rate of bromination increased following a bromination order of 0.66 with respect to APP concentration. This has been ascribed to initial replacement of the hydrogen at the tertiary carbon atoms followed by enhanced ease of abstraction from the neighbouring secondary and primary carbon atoms. The apparent activation energy was found to be 11.9 kcal/mol. The rate of bromination increases with an increase of the APP: Br2 molar ratio up to 1 : 1, beyond which the rate becomes independent of this ratio. Mechanism of bromination appears to be an initial substitution of tertiary H-atoms by bromine radicals followed subsequently by replacement of secondary and primary H-atoms via either progressive substitution or elimination-addition. IR spectra confirm the presence of bromine in the samples.
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  • 69
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    Biopolymers 26 (1987), S. 5-8 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
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  • 70
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    Biopolymers 26 (1987), S. 213-229 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We present a theoretical basis and new methods for the determination of thermodynamic functions from scanning calorimetry data. A thermodynamic state is defined here as an ensemble of microstates in the system, and it can be defined only through assumptions of its heat capacity function and the two integral constants. With these assumptions, scanning calorimetry data can be analyzed using the single or double (or multi-) deconvolution presented here. New equations to calculate the van't Hoff enthalpy function and the calorimetric enthalpy function are presented. We prove that the agreement of these two functions is a necessary and sufficient factor for the condition that the system can be described with the assumed two-state model.
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  • 71
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    Biopolymers 26 (1987), S. 251-260 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Infrared absorption and ir linear dichroism measurements have been performed on poly[d(A-T)-Cs+] films at various relative humidities. At high relative humidity, samples are in a B form; at low relative humidity, in a C form. The B → C conformational transition is shown to be a noncooperative one corresponding to a gradual evolution of the backbone geometry of the polynucleotide within the B family. the C-form-type spectrum is characteristic of an alternated phosphodiester chain with a dinucleotidic repeat unit.
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  • 72
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    Biopolymers 26 (1987) 
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    Keywords: Chemistry ; Polymer and Materials Science
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  • 73
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
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    Topics: Chemistry and Pharmacology
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  • 74
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    Biopolymers 26 (1987), S. 403-414 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Molecular mechanical simulations on base-paired deoxyhexanucleoside phosphates, (dAdT)3 · (dAdT)3, (dTdA)3 · (dTdA)3, (dGdC)3 · (dGdC)3, and (dCdG)3 · (dCdG)3, have been carried out to assess their energetic stabilities in left- and right-handed forms. These hexamers have also been simulated with alternating sugar-puckering profiles with the combinations (purine : C2′-endo-pyrimidine : C3′-endo) and (purine : C3′-endo-pyrimidine C2′-endo). The right-handed models have been found to be the energetically most stable structures and the left-handed structures are significantly destabilized. This instability has been rationalized in terms of competition between stabilizing stacking interactions on one hand, and distortions in the bond angles and torsion angles in the sugar-phosphate backbone on the other.
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  • 75
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The flexibility of hairpin loops containing n bases (residues) has been examined using a theoretical model [N. L. Marky and W. K. Olson (1982), Biopolymers, 21, 2329-2344] of oligonucleotide loop closure. The study is based on correlated probabilities of chain separation and terminal residue orientation as outlined previously. The probabilities are calculated using standard statistical mechanical methods as functions of local conformational changes of the chain backbone. Our results for an RNA chain of 9 residues suggest that the anticodon loop is a dynamic structure capable of assuming a variety of different spatial conformations. Free energy values related to the various conformations span a narrow range of values (2-4 kcal/mole) and compare well with experimental observations in aqueous solution. Conformational transitions between the loop conformations are within less than 0.5 kcal/mole in free energy. The different spatial loop conformations and the likely pathways between them may have potential relevance to the molecular translation of the genetic code.
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  • 76
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    Biopolymers 26 (1987), S. 463-480 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Secondary-structure prediction has been used to investigate the conformation of the N- and C-terminal telopeptides for type I and type III collagen. The three predictive methods (Chou and Fasman, Robson and co-workers, Lim) indicate mainly aperiodic conformations. A common structural motif is provided by the positioning of β-turns, particularly in the vicinity of the residue sites involved in intermolecular cross-links. An alternative model to that of Helseth et al [(1979) Biopolymers 18, 3005-3014] for the secondary structure of the N-terminal telopeptide of type I collagen is proposed. The general features of these two contrasting structures have been surveyed by model-building techniques employing molecular graphics and energy minimization. The role of the telopeptide component in the structural design of the biomaterial collagen is assessed. Notably, the alternative model clearly serves to demonstrate the compatibility of current cross-linking evidence with the quasi-hexagonal model for the packing of molecules within a collagen fibril.
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  • 77
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    Keywords: Chemistry ; Polymer and Materials Science
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    Topics: Chemistry and Pharmacology
    Notes: Conformational analysis from the pattern and intensities of cross-peaks in the two-dimensional nuclear Overhauser effect proton nmr spectra of the homopolymer, poly(dA) · poly(dT), and the analogous oligomer, d(AAAAAATTTTTT)2, indicate that they both exist in the B-conformation. The conformation of the ApT/TpA junction in the oligomer is significantly different from the rest of the base pairs.
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  • 78
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    Biopolymers 26 (1987) 
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  • 79
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    Biopolymers 26 (1987), S. 609-611 
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    Keywords: Chemistry ; Polymer and Materials Science
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  • 80
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    Biopolymers 26 (1987) 
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    Keywords: Chemistry ; Polymer and Materials Science
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  • 81
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    Biopolymers 26 (1987), S. iii 
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  • 82
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    Biopolymers 26 (1987), S. 1-3 
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    Keywords: Chemistry ; Polymer and Materials Science
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    Topics: Chemistry and Pharmacology
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    Biopolymers 26 (1987), S. 27-43 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The influence of calcium ions on the polymerization induced in fibrinogen solutions by thrombin and by Reptilase has been investigated by meansof static and dynamic light scattering in combination with measurements of the release of the fibrinopeptide A. The calcium concentration was varied in the range between 0.3 and 103 calcium ions per fibrinogen molecule. The enzyme concentration was chosen sufficiently low so that it was possible to make quantitative observations as a function of time, in particular, beforethe onset of gelation. Likewise, the influence of calcium ions on the enzymatically induced polymerization of fragment X was studied. The results indicate that there are at least three mechanisms by which calcium can influence the evolution of the polymer system on the path to gelation and clotting. Which mechanism dominates depends upon the calcium concentration.
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    Biopolymers 26 (1987), S. 17-26 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We examined the variation in the solvent accessibility and hydrophobicity of the amino acids along the sequences of 58 soluble globular proteins with known tertiary structure. We found that there is a significant tendency for the accessibilities to run in clusters along the sequence but that the hydrophobicities are distributed without such nonrandom clusters. Theseresults suggest severe limitations on the power of sequence analysis tools that use average hydrophobicity scores of overlapping subsequences to predict accessibility.
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    Biopolymers 26 (1987), S. 109-119 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The CD helix bands for infinitely long helical polymers are shown tobe composed of two parts: a derivative-shaped band plus an ordinary Gaussian-like band. The derivative-shaped band results from the zero-order term of an expansion while the Gaussian-like band results from the first-order expansion term. However, the intensities of the two bands are shown to be of the same order of magnitude. They are both linear in the coulombic coupling of transition charge densities for polymer transitions. The sum yields a skewed derivative-shaped band. The shapes of net CD helix bands are shown to not depend on the approximations used for averaging over orientations if the usual systems, such as polypeptides and polynucleotides, are considered in their long-wave-length spectral regions.
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    Biopolymers 26 (1987), S. 137-168 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A procedure, CONGEN, for uniformly sampling the conformational spaceof short polypeptide segments in proteins has been implemented. Because thetime required for this sampling grows exponentially with the number of residues, parameters are introduced to limit the conformational space that has to be explored. This is done by the use of the empirical energy function ofCHARMM [B. R. Brooks, R. E. Bruccoleri, B. D. Olafson, D. J. States, S. Swaminathan and M. Karplus (1983) J. Comput. Chem. 4, 187-217] and truncating the search when conformations of grossly unfavorable energy are sampled. Tests are made to determine control parameters that optimize the search without excluding important configurations. When applied to known protein structures, the resulting procedure is generally capable of generating conformations where the lowest energy conformation matches the known structure within a rms deviation of 1 Å.
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  • 87
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The binding of tris(2,2′-bipyridyl)ruthenium(II) cations [Ru(bpy)2+3] with single- and double-stranded (ss and ds) DNA, and the polynucleotides poly(A), poly(C), poly(G), poly(I), poly(I) · poly(C), and poly(U), was studied in aqueous solution. Steady-state electrical conductivity measurements with the polynucleotides, ssDNA, and dsDNA reveal that approximately three nucleotides offer one binding site. This may be compared with the ratio [nucleotide]/[Mg2+] of 2.4 : 1 for dsDNA. After laser excitation (353 nm), the luminescence of Ru(bpy)2+3 bound to nucleic acids shows two decay components. The contribution of the fast component, which is interpreted as resulting from quenching processes of the absorbed ruthenium complex, exhibits a maximum with increasing [nucleotide]/[Ru(bpy)2+3] at a ratio of about three to one. Bound Ru(bpy)2+3 can be released from the strand by addition of NaClO4 [half-concentration: 2.5 and ≤ 10 mM for poly(U) and dsDNA, respectively].
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  • 88
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    Keywords: Chemistry ; Polymer and Materials Science
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    Topics: Chemistry and Pharmacology
    Notes: One approach to finding the conformation of minimum energy for a complicated molecule is to perform energy minimization, perhaps coupled to more exhaustive search procedures such as dynamics or Monte Carlo sampling, from many starting conformation. Where there are geometric constraints on the conformations, as in a ring molecule, or a variable loop starting and ending in known constant regions of one of a series of homologous proteins, rapidly generating many such starting conformations, all satisfying the constraints, has been a problem in the past. We have devised an algorithm, which we call random tweak, which performs this task in the context of a torsional description of a molecule, and have used it to model the backbones of the six CDRs (complementarity determining regions) of the immunoglobulin MCPC603. These range in size from 5 to 19 residues, and have from 8 to 36 variable dihedral angles. Ensembles of 100 properly closed backbone structures for each CDR were generated under several conditions of van der Waals screening internally and against the rest of the molecule, and ensembles of 1000 were generated for selected CDRs. These structure “libraries” reveal how the geometry at the base of a CDR and the topography of the surrounding protein surface restrict the region of space that a given CDR can occupy. In accord with simple notions of chain molecule statistics, the more highly extended a CDR at its base, the more similar the possible structures and the fewer that are necessary to span the conformational space. Energy minimization and molecular dynamics studies (reported elsewhere) using these libraries to furnish starting conformations show that, as the number of residues in a CDR goes from five to nine, the number of randomly generated structures necessary to ensure that low-lying energetic minima, such as the native conformation, will be found several times goes from a few tens to a few hundred. Some of the spatial features of an ensemble of random conformations are implicit in the histogram of the rms atomic displacements calculated for all the pairs in the ensemble. The random tweak method is carried out by setting each dihederal angle on the main chain of the variable fragment to a random value, then using an iterated linearized Lagrange multiplier technique to enforce the geometric constraints with the minimal conformational perturbation. The time required for the algorithm is linear in fragment length, and the resulting ability of the method to handle large loops makes it especially applicable to the modeling of homologous proteins. In most cases, hundreds of acceptable structures could be generated in a few hours on a VAX 11/780. Where van der Waals screening against fixed atoms need not be performed, as for isolated ring molecules, generation times go down by an order of magnitude or more.
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    Biopolymers 26 (1987), S. 1717-1729 
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    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dynamic light-scattering measurements were carried out for collagen in acetate buffer (pH 4.8) extracted from lathyritic ratskin. The correlation functions were analyzed in terms of the semiflexibility of collagen molecules. The experimental Γ/K2 vs K2 relationship was compared with the theoretical one based on formulation including anisotropy in translational diffusion, chain flexibility, and the hydrodynamic interaction; Γ is the average decay rate and K is the magnitude of the momentum transfer vector. By using the model parameters evaluated from the Γ/K2 vs K2 relationship, a good agreement was obtained between profiles of theoretical and experimental correlation functions over the entire delay times. Detailed examinations of the dynamic light-scattering spectrum permitted us to conclude that a set of the contour length L of 300 nm and the Kuhn length γ-1 of 340 nm are much more probable than other sets of L and γ-1 that equally explain static quantities such as the radius of gyration. The results show that collagen molecules are well characterized by a wormlike chain model.
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  • 90
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    Topics: Chemistry and Pharmacology
    Notes: We have studied the absorption bands of oxy- and carbonmonoxyhemoglobin in the wavelength range of 650-350 nm (visible and Soret bands) and in the temperature range of 300-20 K. The spectra in the whole temperature range have been successfully deconvoluted in terms of gaussian components. The analysis of the temperature dependence of the first and second moment of the bands enables us to compare dynamic properties of the heme group in oxy- and carbonmonoxyhemoglobin. The results of the analysis indicate that the “mean-effective” frequency of the nuclear motion coupled to the electronic transition responsible for the visible bands is higher in carbonmonoxy- than in oxyhemoglobin. The possible functional relevance of this finding is discussed.
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    Biopolymers 26 (1987), S. 1789-1807 
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    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new static model of enzymatic cleavage of polymeric substrates such as nucleic acids has been derived. The model is compared to that elaborated by Tanford and to experimental data. In predicting the fragment distribution for a restriction enzyme digestion of a circular substrate, the model is superior to that of Tanford.
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  • 92
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
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    Topics: Chemistry and Pharmacology
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    Biopolymers 26 (1987), S. 1431-1444 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The allowed conformations of the μ-receptor-selective cyclic opioid peptide analog were determined using a grid search through the entire conformational space. Energy minimization of the 13-membered ring structure lacking the exocyclic Tyr1 residue and the Phe3 side chain using the molecular mechanics program Maximin resulted in only four low-energy conformations. These four ring structures served as templates for a further energy minimization study with the Tyr1 residue and Phe3 side chain added to the molecule. The results indicated that the Tyr1 and Phe3 side chains enjoy considerable orientational freedom, but nevertheless, only a limited number of low-energy side-chain configurations were found. The obtained low-energy conformers are discussed in relation to various proposed models of the bioactive conformation of enkephalins and morphiceptin.
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  • 94
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    Topics: Chemistry and Pharmacology
    Notes: The conformational equilibria of seven methyl β-D-mannobioside conformers have been studied theoretically in five solvents. The structure of each individual conformer has been refined by the PCILO quantum-chemical method from the seven distinct low-energy regions determined from (Φ, Ψ) maps calculated by a potential function method. The stability of the conformers in dilute solution has been evaluated by using a method that consists of electrostatic, dispersion, and cavity terms. The calculated abundance of conformers depends on the solvent and results indicate that the preponderant conformer in the solution may not be the one adopted by mannobiose in the crystalline form. Based on the determined abundance of conformers, thermodynamically averaged nmr parameters, dipole moment, and linkage rotation have been calculated. The solvation behavior of methyl β-D-mannobioside is compared to those previously estimated for cellobiose and maltose.
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    Biopolymers 26 (1987), S. 1509-1526 
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    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The nonspecific interaction of the mitogenic lectin Concanavalin A (Con A) with glycosyl-free liposomes of various composition has been investigated by microcalorimetric titration measurements. The results obtained show the following features of main interest: (1) the affinity constants (Ka) of the interaction of Con A with liposomal bilayers are in the order of magnitude 105-106M-1. The reaction enthalpies (ΔH) are positive, and small (approximately 0.1 KJ mol-1 lipid), compared to the free energy terms (-ΔG = 30-40 KJ mol-1 lipid). All lectin-lipid interactions are strongly entropy-controlled (ΔH/TΔS 〈 1.0). These thermodynamic features are characteristic for hydrophobic interaction processes. (2) The liposomal head-group charge does not significantly affect the lipid-affinity of Con A. Electrostatic forces thus appear to play a minor role in lectin-lipid interactions. (3) The lipid affinity of Con A is sensitive to the fluidity of the liposomal bilayers, increasing with increasing fluidity. Below the gel to liquid-crystal phase transition temperature, the lectin binding to liposomal bilayers is inhibited. (4) The binding isotherms, corresponding to the interaction of Con A with liposomes, composed of tightly packed, saturated phospholipids, exhibit pronounced positive cooperativity. This phenomenon is absent in the binding curves, corresponding to the interaction of Con A with more fluid liposomal bilayers. (5) The Con A specific inhibitor α-D-methylmannopyranoside (50 mM) drastically increases the molar reaction enthalpy. The Ka term is significantly reduced in presence of the inhibitor sugar. Urea induces analogous changes in the thermodynamic parameters of the lectin-lipid interaction. The effects of α-D-methylmannopyranoside are thus not Con A specific, but are attributable to solvent effects. (6) It was shown that the binding of one Con A molecule affects a large number (approximately 1000) of phospholipid molecules in the liposomal bilayer. (7) The affinity constants (Ka) of the interaction of Con A with glycosyl-free lipids are smaller by a factor of approximately 10, compared to the Ka terms, reported for Con A binding to biological membranes. The presence of glycosidic receptor groups thus controls the specificity of lectin-membrane interactions, whereas the nonspecific lectin-lipid interactions appear to represent the main driving force for the strong attachment of the lectin to membrane surfaces.
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  • 96
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 1601-1620 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this paper, we derive the general forms of the equations required to extract thermodynamic data from equilibrium transition curves on oligomeric and polymeric nucleic acids of any molecularity. Significantly, since the equations and protocols are general, they also can be used to characterize thermodynamically equilibrium processes in systems other than nucleic acids. We briefly review how the reduced forms of the general equations have been used by many investigators to evaluate mono- and bimolecular transitions, and then explain how these equations can be generalized to calculate thermodynamic parameters from common experimental observables for transitions of higher molecularities. We emphasize the strengths and weaknesses of each method of data analysis so that investigators can select the approach most appropriate for their experimental circumstances. We also describe how to analyze calorimetric heat capacity curves and noncalorimetric differentiated melting curves so as to extract both model-independent and model-dependent thermodynamic data for transitions of any molecularity. The general equations and methods of analysis described in this paper should be of particular interest to laboratories that currently are investigating association and dissociation processes in nucleic acids that exhibit molecularities greater than two.
    Additional Material: 4 Ill.
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  • 97
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We report the solid-phase synthesis and conformational analysis of a 14-membered, cyclic enkephalin analog, H—Tyr—c[—D—A2bu—Gly—Phe—D—Leu—] (where A2bu represents α,γ-diaminobutyric acid). The results from the guinea pig ileum (GPI) and mouse vas deferens (MVD) assays show that the analog, though active, has little selectivity for the μ or δ opioid receptors. Conformational analysis is carried out using 1H-nmr and computer simulations, including molecular dynamics and energy minimizations. The results obtained here are compared with the findings of our studies carried out on the μ-receptor-selective diastereomer, H—Tyr—c[—D—A2bu—Gly—Phe—Leu—] [N. Mammi, M. Hassan, and M. Goodman (1985) J. Am. Chem. Soc. 107, 4008-4013]. This comparison allows for insight into the regiospecificity of these cyclic enkephalin analogs.
    Additional Material: 3 Ill.
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  • 98
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Plasma fibronectin is a 450-kD glycoprotein composed of two similar subunits connected by interchain disulfide bridges that may fold over in solution, allowing the amino terminus of each chain to bind the carboxyl terminus of the same subunit or a different subunit, thereby allowing polymerization. In order to study the characteristics of the fold-over interaction, the interaction between the amino terminal 29-kD fragment of fibronectin with native fibronectin has been studied in detail. One 29-kD molecule bound per fibronectin subunit, the apparent equilibrium dissociation constant was 40 nM, and the half-times for association and dissociation at 22°C were, respectively, 16 h and 23 days. Complexation could be inhibited by high concentrations of salt, but not by 8M urea. Amino terminal 20-kD and carboxyl terminal 8-kD subfragments of the 29-kD fragment also bound fibronectin and the activity was dependent on the integrity of the type 1 loop structures. The kinetics of the interaction of 29-kD fragment with fibronectin were unaffected by the presence of ligands, but were affected by detergents such as sodium dodecyl sulfate or deoxycholate, which enhanced the rate of interaction over 100-fold or 6-fold, respectively. Therefore, the interaction of fibronectin with ionic cell membrane components such as deoxycholate in vivo may trigger polymerization.
    Additional Material: 6 Ill.
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  • 99
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. Si 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
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  • 100
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. S25 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis, spectroscopy, and computer simulations are used in an integrated approach to elucidate secondary structure of oligopeptides. Three lactam-bridge peptides were synthesized and examined. One of these model compounds was shown to prefer a β-turn conformation, as indicated by spectroscopy (CD and nmr), and by computer simulations of minimum potential energy and of molecular dynamics. Partial retro-inverso cyclic analogs of enkephalin were also synthesized and investigated. Biological activity studies of the analogs indicated that the Gly3 carbonyl group and the side-chain orientation of the L-Leu5 residue are important. Hydrogen-bonding patterns for the three analogs are described in terms of the spectroscopic evidence correlated to the molecular dynamics simulations.
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