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  • 1
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    Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors [Neuroscience] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-02-29
    Description: The endocannabinoid (eCB) system is widely expressed throughout the central nervous system (CNS) and the functionality of type-1 cannabinoid receptors in neurons is well documented. In contrast, there is little knowledge about type-2 cannabinoid receptors (CB2Rs) in the CNS. Here, we show that CB2Rs are located intracellularly in layer II/III pyramidal cells of the rodent medial prefrontal cortex (mPFC) and that their activation results in IP3R-dependent opening of Ca2+-activated Cl− channels. To investigate the functional role of CB2R activation, we induced neuronal firing and observed a CB2R-mediated reduction in firing frequency. The description of this unique CB2R-mediated signaling pathway, controlling neuronal excitability, broadens our knowledge of the influence of the eCB system on brain function.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Temporary reprieve for stem cells (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Sep 16;467(7313):258-9. doi: 10.1038/467258a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844505" target="_blank"〉PubMed〈/a〉
    Keywords: *Embryonic Stem Cells ; Financing, Organized/economics/*organization & administration ; Humans ; Induced Pluripotent Stem Cells ; National Institutes of Health (U.S.)/*economics/*legislation & jurisprudence ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    US stem-cell chaos felt abroad (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Sep 9;467(7312):138-9. doi: 10.1038/467138a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829764" target="_blank"〉PubMed〈/a〉
    Keywords: Cooperative Behavior ; Embryo Research/*economics ; Humans ; Internationality ; Research Support as Topic/legislation & jurisprudence ; *Stem Cells ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Francis Collins: One year at the helm (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Aug 12;466(7308):808-10. doi: 10.1038/466808a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20703281" target="_blank"〉PubMed〈/a〉
    Keywords: American Recovery and Reinvestment Act/economics ; Biomedical Research/economics/organization & administration/trends ; Budgets/trends ; Comparative Effectiveness Research ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; National Institutes of Health (U.S.)/*economics/*organization & ; administration/trends ; Religion and Science ; Translational Medical Research ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    NIH set to tighten financial rules for researchers (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 May 27;465(7297):407. doi: 10.1038/465407a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20505703" target="_blank"〉PubMed〈/a〉
    Keywords: Conflict of Interest/*legislation & jurisprudence ; National Institutes of Health (U.S.)/*legislation & jurisprudence ; Research Personnel/economics/ethics/*legislation & jurisprudence ; Research Support as Topic/economics/legislation & jurisprudence ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Funding crisis hits US ageing research (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-11-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Nov 11;468(7321):148. doi: 10.1038/468148a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21068800" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alzheimer Disease/economics/epidemiology/genetics ; American Recovery and Reinvestment Act/economics ; Biomedical Research/*economics ; Financing, Government/economics/*statistics & numerical data ; Financing, Organized/economics/statistics & numerical data ; Humans ; National Institute on Aging (U.S.)/*economics ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Diseased cells fail to win approval (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Jun 17;465(7300):852. doi: 10.1038/465852a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20559353" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Consent Forms/*ethics/standards ; *Embryonic Stem Cells ; Humans ; National Institutes of Health (U.S.)/*ethics/legislation & ; jurisprudence/standards ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    US midterm elections: NIH prepares for loss of political champions (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Oct 14;467(7317):761. doi: 10.1038/467761a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944702" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Federal Government ; Humans ; National Institutes of Health (U.S.)/economics/*legislation & jurisprudence ; *Politics ; Research Support as Topic/economics/trends ; Stem Cell Research/economics/*legislation & jurisprudence ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Plan for addiction institute splits NIH (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Oct 7;467(7316):643. doi: 10.1038/467643a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20930813" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/*organization & administration ; Humans ; National Institute on Alcohol Abuse and Alcoholism (U.S.)/economics/*organization ; & administration ; National Institute on Drug Abuse (U.S.)/economics/*organization & administration ; *Substance-Related Disorders/complications/physiopathology ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Stem-cell work thrown into limbo (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2010 Sep 2;467(7311):12-3. doi: 10.1038/467012a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20811425" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Embryo Research/*economics/*legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government/*legislation & jurisprudence ; Humans
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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