Publication Date:
1985-11-01
Description:
The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gidoni, D -- Kadonaga, J T -- Barrera-Saldana, H -- Takahashi, K -- Chambon, P -- Tjian, R -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):511-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996137" target="_blank"〉PubMed〈/a〉
Keywords:
Autoradiography
;
Base Sequence
;
Binding Sites
;
DNA-Binding Proteins/*metabolism
;
Deoxyribonuclease I/metabolism
;
Electrophoresis, Polyacrylamide Gel
;
Gene Expression Regulation
;
Mutation
;
Pregnancy Proteins/*metabolism
;
RNA, Messenger/analysis
;
RNA, Viral/biosynthesis
;
Simian virus 40/*genetics
;
Sp1 Transcription Factor
;
Templates, Genetic
;
Transcription Factors/*metabolism
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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