Publication Date:
1985-08-09
Description:
The T-cell receptor beta-chain gene has a nuclease hypersensitive site in several kinds of T cells, which does not appear in B cells expressing immunoglobulins. Conversely, the kappa immunoglobulin gene shows a known hypersensitive site at its enhancer element in B cells, as expected, but this site is absent in T cells. As is the case with immunoglobulin genes, the T-cell receptor site lies within the gene, in the intron separating joining and constant region segments. These nuclease hypersensitive DNA configurations in the introns of active T-cell receptor and immunoglobulin genes may arise from control elements that share ancestry but have diverged to the extent that each normally acts only in lymphoid cells which use the proximal gene product.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bier, E -- Hashimoto, Y -- Greene, M I -- Maxam, A M -- AI 19901/AI/NIAID NIH HHS/ -- CA 22427/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 9;229(4713):528-34.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3927483" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/metabolism
;
Base Sequence
;
Binding Sites
;
Cell Line
;
Chromosome Mapping
;
Collodion
;
Deoxyribonuclease I/*metabolism
;
Enhancer Elements, Genetic
;
Gene Expression Regulation
;
Humans
;
Hybridomas
;
Immunochemistry
;
Immunoglobulin Fragments/*genetics
;
Immunoglobulin Heavy Chains/genetics
;
Immunoglobulin kappa-Chains/genetics
;
Mice
;
Receptors, Antigen, T-Cell/*genetics
;
T-Lymphocytes/*metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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