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  • Science. 226(4674): 521.  (3)
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  • 1
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    Unbekannt
    Universal Quantum Simulators (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-23
    Beschreibung: Feynman's 1982 conjecture, that quantum computers can be programmed to simulate any local quantum system, is shown to be correct.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd -- New York, N.Y. -- Science. 1996 Aug 23;273(5278):1073-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The author is at the D'Arbeloff Laboratory for Information Systems and Technology, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: slloyd@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688088" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-02
    Beschreibung: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR). Treatment of cultured murine adipocytes with TNF-alpha was shown to induce serine phosphorylation of insulin receptor substrate 1 (IRS-1) and convert IRS-1 into an inhibitor of the IR tyrosine kinase activity in vitro. Myeloid 32D cells, which lack endogenous IRS-1, were resistant to TNF-alpha-mediated inhibition of IR signaling, whereas transfected 32D cells that express IRS-1 were very sensitive to this effect of TNF-alpha. An inhibitory form of IRS-1 was observed in muscle and fat tissues from obese rats. These results indicate that TNF-alpha induces insulin resistance through an unexpected action of IRS-1 to attenuate insulin receptor signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotamisligil, G S -- Peraldi, P -- Budavari, A -- Ellis, R -- White, M F -- Spiegelman, B M -- DK 42539/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):665-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571133" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipocytes/*metabolism ; Adipose Tissue/metabolism ; Animals ; Cells, Cultured ; Insulin/pharmacology ; Insulin Receptor Substrate Proteins ; Insulin Resistance/*physiology ; Male ; Mice ; Muscle, Skeletal/metabolism ; Obesity/*metabolism ; Phosphoproteins/metabolism/*physiology ; Phosphorylation ; Rats ; Rats, Zucker ; Receptor, Insulin/*antagonists & inhibitors/metabolism ; Serine/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    The science doctorate (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotchkiss, C E -- New York, N.Y. -- Science. 1996 Feb 9;271(5250):745b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17796302" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Merit, Quality, and the SIBR Program (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whalen, R L -- New York, N.Y. -- Science. 1996 Jun 21;272(5269):1725a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831837" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Persistent site-specific remodeling of a nucleosome array by transient action of the SWI/SNF complex (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-26
    Beschreibung: The SWI/SNF complex participates in the restructuring of chromatin for transcription. The function of the yeast SWI/SNF complex in the remodeling of a nucleosome array has now been analyzed in vitro. Binding of the purified SWI/SNF complex to a nucleosome array disrupted multiple nucleosomes in an adenosine triphosphate-dependent reaction. However, removal of SWI/SNF left a deoxyribonuclease I-hypersensitive site specifically at a nucleosome that was bound by derivatives of the transcription factor Gal4p. Analysis of individual nucleosomes revealed that the SWI/SNF complex catalyzed eviction of histones from the Gal4-bound nucleosomes. Thus, the transient action of the SWI/SNF complex facilitated irreversible disruption of transcription factor-bound nucleosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owen-Hughes, T -- Utley, R T -- Cote, J -- Peterson, C L -- Workman, J L -- GM47867/GM/NIGMS NIH HHS/ -- R01 GM049650/GM/NIGMS NIH HHS/ -- R37 GM049650/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jul 26;273(5274):513-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology and Center for Gene Regulation, Pennsylvania State University, University Park, PA 16802-4500, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662543" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphatases ; Adenosine Triphosphate/metabolism ; Base Sequence ; Binding Sites ; DNA, Fungal/metabolism ; DNA-Binding Proteins/*metabolism ; Deoxyribonuclease I/metabolism ; Fungal Proteins/*metabolism ; Histones/metabolism ; Molecular Sequence Data ; *Nuclear Proteins ; Nucleosomes/*metabolism/ultrastructure ; Saccharomyces cerevisiae ; *Saccharomyces cerevisiae Proteins ; Transcription Factors/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Contraceptive technology. Panel wants to break R&D barrier (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1996 May 31;272(5266):1258.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650534" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Contraceptive Agents/economics ; *Drug Industry/economics/legislation & jurisprudence ; Female ; Humans ; Institute of Medicine (U.S.) ; Insurance, Health ; Liability, Legal ; Male ; *Research/economics ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Explaining "linguistic features" of noncoding DNA (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonhoeffer, S -- Herz, A V -- Boerlijst, M C -- Nee, S -- Nowak, M A -- May, R M -- New York, N.Y. -- Science. 1996 Jan 5;271(5245):14b-5b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17798153" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Origin of replication of Mycoplasma genitalium (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lobry, J R -- New York, N.Y. -- Science. 1996 May 3;272(5262):745-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614839" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Composition ; Chromosomes, Bacterial/*genetics ; DNA Replication ; Genome, Bacterial ; Mycoplasma/*genetics ; *Replication Origin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-29
    Beschreibung: A 13.1-kilodalton protein, cysteine-rich neurotrophic factor (CRNF), was purified from the mollusk Lymnaea stagnalis by use of a binding assay on the p75 neurotrophin receptor. CRNF bound to p75 with nanomolar affinity but was not similar in sequence to neurotrophins or any other known gene product. CRNF messenger RNA expression was highest in adult foot subepithelial cells; in the central nervous system, expression was regulated by lesion. The factor evoked neurite outgrowth and modulated calcium currents in pedal motor neurons. Thus, CRNF may be involved in target-derived trophic support for motor neurons and could represent the prototype of another family of p75 ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fainzilber, M -- Smit, A B -- Syed, N I -- Wildering, W C -- Hermann -- van der Schors, R C -- Jimenez, C -- Li, K W -- van Minnen, J -- Bulloch, A G -- Ibanez, C F -- Geraerts, W P -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1540-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Berzelius Laboratories Building, Doktorsringen 12A, S-17177 Stockholm, Sweden. michael@cajal.mbb.ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8929417" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Binding, Competitive ; Calcium/metabolism ; Hemolymph/chemistry ; Humans ; Lymnaea/*chemistry ; Molecular Sequence Data ; Motor Neurons/ultrastructure ; Nerve Growth Factors/chemistry/genetics/isolation & ; purification/metabolism/*physiology ; Neurites/physiology ; RNA, Messenger/genetics/metabolism ; Receptor, Nerve Growth Factor ; Receptors, Nerve Growth Factor/*metabolism ; Recombinant Proteins/chemistry/isolation & purification/metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    Just how old is that DNA, anyway? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1996 May 10;272(5263):810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629007" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Amber/chemistry ; Amino Acids/*chemistry ; Animals ; DNA/*analysis/chemistry ; *Fossils ; History, Ancient ; *Paleontology ; Stereoisomerism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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