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Nature Communications. 2021; 12(1): 1000. Published 2021 Feb 12. doi: 10.1038/s41467-021-21138-y. (1)
Nature Communications. 2021; 12(1): 1001. Published 2021 Feb 12. doi: 10.1038/s41467-021-21157-9. (1)
Nature Communications. 2021; 12(1): 1002. Published 2021 Feb 12. doi: 10.1038/s41467-021-21191-7. (1)
Nature Communications. 2021; 12(1): 1003. Published 2021 Feb 12. doi: 10.1038/s41467-021-21162-y. (1)
Nature Communications. 2021; 12(1): 1004. Published 2021 Feb 12. doi: 10.1038/s41467-021-21166-8. (1)
Nature Communications. 2021; 12(1): 1005. Published 2021 Feb 12. doi: 10.1038/s41467-021-21284-3. (1)
Nature Communications. 2021; 12(1): 1006. Published 2021 Feb 12. doi: 10.1038/s41467-021-21303-3. (1)
Nature Communications. 2021; 12(1): 1007. Published 2021 Feb 12. doi: 10.1038/s41467-021-21338-6. (1)
Nature Communications. 2021; 12(1): 1008. Published 2021 Feb 12. doi: 10.1038/s41467-021-21182-8. (1)
Nature Communications. 2021; 12(1): 1009. Published 2021 Feb 12. doi: 10.1038/s41467-021-21109-3. (1)
Nature Communications. 2021; 12(1): 1010. Published 2021 Feb 12. doi: 10.1038/s41467-021-21086-7. (1)
Nature Communications. 2021; 12(1): 1011. Published 2021 Feb 12. doi: 10.1038/s41467-021-21366-2. (1)
Nature Communications. 2021; 12(1): 1012. Published 2021 Feb 12. doi: 10.1038/s41467-020-20799-5. (1)
Nature Communications. 2021; 12(1): 1013. Published 2021 Feb 12. doi: 10.1038/s41467-021-21129-z. (1)
Nature Communications. 2021; 12(1): 1014. Published 2021 Feb 12. doi: 10.1038/s41467-021-21117-3. (1)
Nature Communications. 2021; 12(1): 1015. Published 2021 Feb 12. doi: 10.1038/s41467-021-21183-7. (1)
Nature Communications. 2021; 12(1): 1016. Published 2021 Feb 15. doi: 10.1038/s41467-021-21331-z. (1)
Nature Communications. 2021; 12(1): 1017. Published 2021 Feb 15. doi: 10.1038/s41467-021-21332-y. (1)
Nature Communications. 2021; 12(1): 1018. Published 2021 Feb 15. doi: 10.1038/s41467-021-21336-8. (1)
Nature Communications. 2021; 12(1): 1019. Published 2021 Feb 15. doi: 10.1038/s41467-021-21340-y. (1)
134647
Natural Sciences in General (2,557)
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Nature Communications. 2021; 12(1): 1000. Published 2021 Feb 12. doi: 10.1038/s41467-021-21138-y. (1)
Nature Communications. 2021; 12(1): 1001. Published 2021 Feb 12. doi: 10.1038/s41467-021-21157-9. (1)
Nature Communications. 2021; 12(1): 1002. Published 2021 Feb 12. doi: 10.1038/s41467-021-21191-7. (1)
Nature Communications. 2021; 12(1): 1003. Published 2021 Feb 12. doi: 10.1038/s41467-021-21162-y. (1)
Nature Communications. 2021; 12(1): 1004. Published 2021 Feb 12. doi: 10.1038/s41467-021-21166-8. (1)

Nature Communications. 2021; 12(1): 1005. Published 2021 Feb 12. doi: 10.1038/s41467-021-21284-3. (1)

Nature Communications. 2021; 12(1): 1006. Published 2021 Feb 12. doi: 10.1038/s41467-021-21303-3. (1)

Nature Communications. 2021; 12(1): 1007. Published 2021 Feb 12. doi: 10.1038/s41467-021-21338-6. (1)

Nature Communications. 2021; 12(1): 1008. Published 2021 Feb 12. doi: 10.1038/s41467-021-21182-8. (1)

Nature Communications. 2021; 12(1): 1009. Published 2021 Feb 12. doi: 10.1038/s41467-021-21109-3. (1)

Nature Communications. 2021; 12(1): 1010. Published 2021 Feb 12. doi: 10.1038/s41467-021-21086-7. (1)

Nature Communications. 2021; 12(1): 1011. Published 2021 Feb 12. doi: 10.1038/s41467-021-21366-2. (1)

Nature Communications. 2021; 12(1): 1012. Published 2021 Feb 12. doi: 10.1038/s41467-020-20799-5. (1)

Nature Communications. 2021; 12(1): 1013. Published 2021 Feb 12. doi: 10.1038/s41467-021-21129-z. (1)

Nature Communications. 2021; 12(1): 1014. Published 2021 Feb 12. doi: 10.1038/s41467-021-21117-3. (1)

Nature Communications. 2021; 12(1): 1015. Published 2021 Feb 12. doi: 10.1038/s41467-021-21183-7. (1)

Nature Communications. 2021; 12(1): 1016. Published 2021 Feb 15. doi: 10.1038/s41467-021-21331-z. (1)

Nature Communications. 2021; 12(1): 1017. Published 2021 Feb 15. doi: 10.1038/s41467-021-21332-y. (1)

Nature Communications. 2021; 12(1): 1018. Published 2021 Feb 15. doi: 10.1038/s41467-021-21336-8. (1)

Nature Communications. 2021; 12(1): 1019. Published 2021 Feb 15. doi: 10.1038/s41467-021-21340-y. (1)

134647

Unknown

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases (2021)

Kapoor, Manav ; Chao, Michael J. ; Johnson, Emma C. ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5071. Published 2021 Aug 20. doi: 10.1038/s41467-021-25392-y.

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Publication Date: 2021-08-20

Description: Identification of causal variants and genes underlying genome-wide association study (GWAS) loci is essential to understand the biology of alcohol use disorder (AUD) and drinks per week (DPW). Multi-omics integration approaches have shown potential for fine mapping complex loci to obtain biological insights to disease mechanisms. In this study, we use multi-omics approaches, to fine-map AUD and DPW associations at single SNP resolution to demonstrate that rs56030824 on chromosome 11 significantly reduces SPI1 mRNA expression in myeloid cells and lowers risk for AUD and DPW. Our analysis also identifies MAPT as a candidate causal gene specifically associated with DPW. Genes prioritized in this study show overlap with causal genes associated with neurodegenerative disorders. Multi-omics integration analyses highlight, genetic similarities and differences between alcohol intake and disordered drinking, suggesting molecular heterogeneity that might inform future targeted functional and cross-species studies.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Ultrahigh-speed graphene-based optical coherent receiver (2021)

Wang, Yilun ; Li, Xiang ; Jiang, Zhibin ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5076. Published 2021 Aug 20. doi: 10.1038/s41467-021-25374-0.

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Publication Date: 2021-08-20

Description: Graphene-based photodetectors have attracted significant attention for high-speed optical communication due to their large bandwidth, compact footprint, and compatibility with silicon-based photonics platform. Large-bandwidth silicon-based optical coherent receivers are crucial elements for large-capacity optical communication networks with advanced modulation formats. Here, we propose and experimentally demonstrate an integrated optical coherent receiver based on a 90-degree optical hybrid and graphene-on-plasmonic slot waveguide photodetectors, featuring a compact footprint and a large bandwidth far exceeding 67 GHz. Combined with the balanced detection, 90 Gbit/s binary phase-shift keying signal is received with a promoted signal-to-noise ratio. Moreover, receptions of 200 Gbit/s quadrature phase-shift keying and 240 Gbit/s 16 quadrature amplitude modulation signals on a single-polarization carrier are realized with a low additional power consumption below 14 fJ/bit. This graphene-based optical coherent receiver will promise potential applications in 400-Gigabit Ethernet and 800-Gigabit Ethernet technology, paving another route for future high-speed coherent optical communication networks.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Gold-like activity copper-like selectivity of heteroatomic transition metal carbides for electrocatalytic carbon dioxide reduction reaction (2021)

Esmaeilirad, Mohammadreza ; Baskin, Artem ; Kondori, Alireza ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5067. Published 2021 Aug 20. doi: 10.1038/s41467-021-25295-y.

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Publication Date: 2021-08-20

Description: An overarching challenge of the electrochemical carbon dioxide reduction reaction (eCO2RR) is finding an earth-abundant, highly active catalyst that selectively produces hydrocarbons at relatively low overpotentials. Here, we report the eCO2RR performance of two-dimensional transition metal carbide class of materials. Our results indicate a maximum methane (CH4) current density of −421.63 mA/cm2 and a CH4 faradic efficiency of 82.7% ± 2% for di-tungsten carbide (W2C) nanoflakes in a hybrid electrolyte of 3 M potassium hydroxide and 2 M choline-chloride. Powered by a triple junction photovoltaic cell, we demonstrate a flow electrolyzer that uses humidified CO2 to produce CH4 in a 700-h process under one sun illumination with a CO2RR energy efficiency of about 62.3% and a solar-to-fuel efficiency of 20.7%. Density functional theory calculations reveal that dissociation of water, chemisorption of CO2 and cleavage of the C-O bond—the most energy consuming elementary steps in other catalysts such as copper—become nearly spontaneous at the W2C surface. This results in instantaneous formation of adsorbed CO—an important reaction intermediate—and an unlimited source of protons near the tungsten surface sites that are the main reasons for the observed superior activity, selectivity, and small potential.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans (2021)

Wang, Feng ; Dai, Yuxi ; Zhu, Xufeng ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5073. Published 2021 Aug 20. doi: 10.1038/s41467-021-25398-6.

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Publication Date: 2021-08-20

Description: The contents of numerous membrane lipids change upon ageing. However, it is unknown whether and how any of these changes are causally linked to lifespan regulation. Acyl chains contribute to the functional specificity of membrane lipids. In this study, working with C. elegans, we identified an acyl chain-specific sphingolipid, C22 glucosylceramide, as a longevity metabolite. Germline deficiency, a conserved lifespan-extending paradigm, induces somatic expression of the fatty acid elongase ELO-3, and behenic acid (22:0) generated by ELO-3 is incorporated into glucosylceramide for lifespan regulation. Mechanistically, C22 glucosylceramide is required for the membrane localization of clathrin, a protein that regulates membrane budding. The reduction in C22 glucosylceramide impairs the clathrin-dependent autophagic lysosome reformation, which subsequently leads to TOR activation and longevity suppression. These findings reveal a mechanistic link between membrane lipids and ageing and suggest a model of lifespan regulation by fatty acid-mediated membrane configuration.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair (2021)

Jamsen, Joonas A. ; Sassa, Akira ; Perera, Lalith ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5055. Published 2021 Aug 20. doi: 10.1038/s41467-021-24486-x.

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Publication Date: 2021-08-20

Description: Reactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase (pol) μ prepares breaks for end-joining and this is required for successful NHEJ in vivo. We previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP), that can lead to mutagenesis, cancer, aging and human disease. Here we reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during DSB repair by pol μ. Time-lapse crystallography snapshots of structural intermediates during nucleotide insertion along with computational simulations reveal substrate, metal and side chain dynamics, that allow oxidized ribonucleotides to escape polymerase discrimination checkpoints. Abundant nucleotide pools, combined with inefficient sanitization and repair, implicate pol μ mediated oxidized ribonucleotide insertion as an emerging source of widespread persistent mutagenesis and genomic instability.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers (2021)

Mao, Ninghui ; Zhang, Zeda ; Lee, Young Sun ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5053. Published 2021 Aug 20. doi: 10.1038/s41467-021-25341-9.

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Publication Date: 2021-08-20

Description: Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal that PI3K isoform dependency is not governed by loss of PTEN and is impacted by feedback inhibition and concurrent PIK3CA/PIK3CB alterations. Furthermore, while pan-PI3K inhibition in PTEN-deficient tumors is efficacious, upregulation of Insulin Like Growth Factor 1 Receptor (IGF1R) promotes resistance. Importantly, we show that this resistance can be overcome through targeting AKT and we find that AKT inhibitors are superior to pan-PI3K inhibition in the context of PTEN loss. However, in the presence of wild-type PTEN and PIK3CA-activating mutations, p110α-dependent signaling is dominant and selectively inhibiting p110α is therapeutically superior to AKT inhibition. These discoveries reveal a more nuanced understanding of PI3K isoform dependency and unveil novel strategies to selectively target PI3K signaling nodes in a context-specific manner.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Detection and characterization of lung cancer using cell-free DNA fragmentomes (2021)

Mathios, Dimitrios ; Johansen, Jakob Sidenius ; Cristiano, Stephen ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5060. Published 2021 Aug 20. doi: 10.1038/s41467-021-24994-w.

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Publication Date: 2021-08-20

Description: Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection model using an independent cohort of 385 non-cancer individuals and 46 lung cancer patients. Combining fragmentation features, clinical risk factors, and CEA levels, followed by CT imaging, detected 94% of patients with cancer across stages and subtypes, including 91% of stage I/II and 96% of stage III/IV, at 80% specificity. Genome-wide fragmentation profiles across ~13,000 ASCL1 transcription factor binding sites distinguished individuals with small cell lung cancer from those with non-small cell lung cancer with high accuracy (AUC = 0.98). A higher fragmentation score represented an independent prognostic indicator of survival. This approach provides a facile avenue for non-invasive detection of lung cancer.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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WS2 moiré superlattices derived from mechanical flexibility for hydrogen evolution reaction (2021)

Xie, Lingbin ; Wang, Longlu ; Zhao, Weiwei ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5070. Published 2021 Aug 20. doi: 10.1038/s41467-021-25381-1.

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Publication Date: 2021-08-20

Description: The discovery of moiré superlattices (MSLs) opened an era in the research of ‘twistronics’. Engineering MSLs and realizing unique emergent properties are key challenges. Herein, we demonstrate an effective synthetic strategy to fabricate MSLs based on mechanical flexibility of WS2 nanobelts by a facile one-step hydrothermal method. Unlike previous MSLs typically created through stacking monolayers together with complicated method, WS2 MSLs reported here could be obtained directly during synthesis of nanobelts driven by the mechanical instability. Emergent properties are found including superior conductivity, special superaerophobicity and superhydrophilicity, and strongly enhanced electro-catalytic activity when we apply ‘twistronics’ to the field of catalytic hydrogen production. Theoretical calculations show that such excellent catalytic performance could be attributed to a closer to thermoneutral hydrogen adsorption free energy value of twisted bilayers active sites. Our findings provide an exciting opportunity to design advanced WS2 catalysts through moiré superlattice engineering based on mechanical flexibility.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Achieving high strength and ductility in ODS-W alloy by employing oxide@W core-shell nanopowder as precursor (2021)

Dong, Zhi ; Ma, Zongqing ; Yu, Liming ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5052. Published 2021 Aug 20. doi: 10.1038/s41467-021-25283-2.

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Publication Date: 2021-08-20

Description: With excellent creep resistance, good high-temperature microstructural stability and good irradiation resistance, oxide dispersion strengthened (ODS) alloys are a class of important alloys that are promising for high-temperature applications. However, plagued by a nerve-wracking fact that the oxide particles tend to aggregate at grain boundary of metal matrix, their improvement effect on the mechanical properties of metal matrix tends to be limited. In this work, we employ a unique in-house synthesized oxide@W core-shell nanopowder as precursor to prepare W-based ODS alloy. After low-temperature sintering and high-energy-rate forging, high-density oxide nanoparticles are dispersed homogeneously within W grains in the prepared alloy, accompanying with the intergranular oxide particles completely disappearing. As a result, our prepared alloy achieves a great enhancement of strength and ductility at room temperature. Our strategy using core-shell powder as precursor to prepare high-performance ODS alloy has potential to be applied to other dispersion-strengthened alloy systems.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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UbiD domain dynamics underpins aromatic decarboxylation (2021)

Marshall, Stephen A. ; Payne, Karl A. P. ; Fisher, Karl ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5065. Published 2021 Aug 20. doi: 10.1038/s41467-021-25278-z.

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Publication Date: 2021-08-20

Description: The widespread UbiD enzyme family utilises the prFMN cofactor to achieve reversible decarboxylation of acrylic and (hetero)aromatic compounds. The reaction with acrylic compounds based on reversible 1,3-dipolar cycloaddition between substrate and prFMN occurs within the confines of the active site. In contrast, during aromatic acid decarboxylation, substantial rearrangement of the substrate aromatic moiety associated with covalent catalysis presents a molecular dynamic challenge. Here we determine the crystal structures of the multi-subunit vanillic acid decarboxylase VdcCD. We demonstrate that the small VdcD subunit acts as an allosteric activator of the UbiD-like VdcC. Comparison of distinct VdcCD structures reveals domain motion of the prFMN-binding domain directly affects active site architecture. Docking of substrate and prFMN-adduct species reveals active site reorganisation coupled to domain motion supports rearrangement of the substrate aromatic moiety. Together with kinetic solvent viscosity effects, this establishes prFMN covalent catalysis of aromatic (de)carboxylation is afforded by UbiD dynamics.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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