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Adaptation of muscle activation after patellar loading demonstrates neural control of joint variables (2019)

Barroso, Filipe O. ; Alessandro, Cristiano ; Tresch, Matthew C.

Springer Nature

In: Scientific Reports. 2019; 9(1): 20370. Published 2019 Dec 01. doi: 10.1038/s41598-019-56888-9.

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Publication Date: 2019-12-01

Description: We evaluated whether the central nervous system (CNS) chooses muscle activations not only to achieve behavioral goals but also to minimize stresses and strains within joints. We analyzed the coordination between quadriceps muscles during locomotion in rats before and after imposing a lateral force on the patella. Vastus lateralis (VL) and vastus medialis (VM) in the rat produce identical knee torques but opposing mediolateral patellar forces. If the CNS regulates internal joint stresses, we predicted that after imposing a lateral patellar load by attaching a spring between the patella and lateral femur, the CNS would reduce the ratio between VL and VM activation to minimize net mediolateral patellar forces. Our results confirmed this prediction, showing that VL activation was reduced after attaching the spring whereas VM and rectus femoris (RF) activations were not significantly changed. This adaptation was reversed after the spring was detached. These changes were not observed immediately after attaching the spring but only developed after 3–5 days, suggesting that they reflected gradual processes rather than immediate compensatory reflexes. Overall, these results support the hypothesis that the CNS chooses muscle activations to regulate internal joint variables.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Chronic oral exposure to field-realistic pesticide combinations via pollen and nectar: effects on feeding and thermal performance in a solitary bee (2019)

Azpiazu, Celeste ; Bosch, Jordi ; Viñuela, Elisa ; [et al.]

Springer Nature

In: Scientific Reports. 2019; 9(1): 13770. Published 2019 Sep 24. doi: 10.1038/s41598-019-50255-4.

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Publication Date: 2019-09-24

Description: Pesticide use is one of the main causes of pollinator declines in agricultural ecosystems. Traditionally, most laboratory studies on bee ecotoxicology test acute exposure to single compounds. However, under field conditions, bees are often chronically exposed to a variety of chemicals, with potential synergistic effects. We studied the effects of field-realistic concentrations of three pesticides measured in pollen and nectar of commercial melon fields on the solitary bee Osmia bicornis L. We orally exposed females of this species throughout their life span to 8 treatments combining two neonicotinoid insecticides (acetamiprid, imidacloprid) and a triazole fungicide (myclobutanil) via pollen and sugar syrup. We measured pollen and syrup consumption, longevity, ovary maturation and thermogenesis. Although bees consumed larger amounts of syrup than pollen, pesticide intake via syrup and pollen were similar. At the tested concentrations, no synergistic effects emerged, and we found no effects on longevity and ovary maturation. However, all treatments containing imidacloprid resulted in suppressed syrup consumption and drastic decreases in thoracic temperature and bee activity. Our results have important implications for pesticide regulation. If we had measured only lethal effects we would have wrongly concluded that the pesticide combinations containing imidacloprid were safe to O. bicornis. The incorporation of tests specifically intended to detect sublethal effects in bee risk assessment schemes should be an urgent priority. In this way, the effects of pesticide exposure on the dynamics of bee populations in agroecosystems will be better assessed.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice (2019)

Patel, Vruti ; Bidault, Guillaume ; Chambers, Joseph E. ; [et al.]

Springer Nature

In: Scientific Reports. 2019; 9(1): 2903. Published 2019 Feb 27. doi: 10.1038/s41598-019-39562-y.

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Publication Date: 2019-02-27

Description: Phosphorylation of the translation initiation factor eIF2α within the mediobasal hypothalamus is known to suppress food intake, but the role of the eIF2α phosphatases in regulating body weight is poorly understood. Mice deficient in active PPP1R15A, a stress-inducible eIF2α phosphatase, are healthy and more resistant to endoplasmic reticulum stress than wild type controls. We report that when female Ppp1r15a mutant mice are fed a high fat diet they gain less weight than wild type littermates owing to reduced food intake. This results in healthy leaner Ppp1r15a mutant animals with reduced hepatic steatosis and improved insulin sensitivity, albeit with a possible modest defect in insulin secretion. By contrast, no weight differences are observed between wild type and Ppp1r15a deficient mice fed a standard diet. We conclude that female mice lacking the C-terminal PP1-binding domain of PPP1R15A show reduced dietary intake and preserved glucose tolerance. Our data indicate that this results in reduced weight gain and protection from diet-induced obesity.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Loss of mRNA surveillance pathways results in widespread protein aggregation (2018)

Jamar, Nur Hidayah ; Kritsiligkou, Paraskevi ; Grant, Chris M.

Springer Nature

In: Scientific Reports. 2018; 8(1): 3894. Published 2018 Mar 01. doi: 10.1038/s41598-018-22183-2.

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Publication Date: 2018-03-01

Description: Eukaryotic cells contain translation-associated mRNA surveillance pathways which prevent the production of potentially toxic proteins from aberrant mRNA translation events. We found that loss of mRNA surveillance pathways in mutants deficient in nonsense-mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD) results in increased protein aggregation. We have isolated and identified the proteins that aggregate and our bioinformatic analyses indicates that increased aggregation of aggregation-prone proteins is a general occurrence in mRNA surveillance mutants, rather than being attributable to specific pathways. The proteins that aggregate in mRNA surveillance mutants tend to be more highly expressed, more abundant and more stable proteins compared with the wider proteome. There is also a strong correlation with the proteins that aggregate in response to nascent protein misfolding and an enrichment for proteins that are substrates of ribosome-associated Hsp70 chaperones, consistent with susceptibility for aggregation primarily occurring during translation/folding. We also identified a significant overlap between the aggregated proteins in mRNA surveillance mutants and ageing yeast cells suggesting that translation-dependent protein aggregation may be a feature of the loss of proteostasis that occurs in aged cell populations.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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ICP4-induced miR-101 attenuates HSV-1 replication (2016)

Wang, Xiangling ; Diao, Caifeng ; Yang, Xi ; [et al.]

Springer Nature

In: Scientific Reports. 2016; 6(1): 23205. Published 2016 Mar 17. doi: 10.1038/srep23205.

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Publication Date: 2016-03-17

Description: Hepes simplex Virus type 1 (HSV-1) is an enveloped DNA virus that can cause lytic and latent infection. miRNAs post-transcriptionally regulate gene expression and our previous work has indicated that HSV-1 infection induces miR-101 expression in HeLa cells. The present study demonstrates that HSV-1-induced miR-101 is mainly derived from its precursor hsa-mir-101-2 and the HSV-1 immediate early gene ICP4 (infected-cell polypeptide 4) directly binds to the hsa-mir-101-2 promoter to activate its expression. RNA-binding protein G-rich sequence factor 1 (GRSF1) was identified as a new target of miR-101; GRSF1 binds to HSV-1 p40 mRNA and enhances its expression, facilitating viral proliferation. Together, ICP4 induces miR-101 expression, which downregulates GRSF1 expression and attenuates the replication of HSV-1. This allows host cells to maintain a permissive environment for viral replication by preventing lytic cell death. These findings indicate that HSV-1 early gene expression modulates host miRNAs to regulate molecular defense mechanisms. This study provides novel insight into host-virus interactions in HSV-1 infection and may contribute to the development of antiviral therapeutics.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Emissions mitigation opportunities for savanna countries from early dry season fire management (2018)

Lipsett-Moore, Geoffrey J. ; Wolff, Nicholas H. ; Game, Edward T.

Springer Nature

In: Nature Communications. 2018; 9(1): 2247. Published 2018 Jun 08. doi: 10.1038/s41467-018-04687-7.

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Publication Date: 2018-06-08

Description: Savanna fires produce significant emissions globally, but if managed effectively could provide an important mitigation opportunity, particularly in African least developed countries. Here we show global opportunities for emissions reductions through early dry season burning for 37 countries including: 29 countries in Africa (69.1 MtCO2-e yr−1), six countries in South America (13.3 MtCO2-e yr−1), and Australia and Papua New Guinea (6.9 MtCO2-e yr−1). Emissions reduction estimates are based on the successful approach developed in Australia to reduce emissions from savanna fires using global-scale, remotely sensed estimates of monthly emissions. Importantly, 20 least developed countries in Africa account for 74% of the mitigation potential (60.2 MtCO2-e yr−1). More than 1.02 million km2 of savanna dominated protected areas within these countries could be used as pilot sites to test and advance a regional approach to mitigation efforts for savanna fires in Africa. Potential versus actual abatement opportunities are discussed.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Intensifying the response of distributed optical fibre sensors using 2D and 3D image restoration (2016)

Soto, Marcelo A. ; Ramírez, Jaime A. ; Thévenaz, Luc

Springer Nature

In: Nature Communications. 2016; 7(1): 10870. Published 2016 Mar 01. doi: 10.1038/ncomms10870.

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Publication Date: 2016-03-01

Description: Distributed optical fibre sensors possess the unique capability of measuring the spatial and temporal map of environmental quantities that can be of great interest for several field applications. Although existing methods for performance enhancement have enabled important progresses in the field, they do not take full advantage of all information present in the measured data, still giving room for substantial improvement over the state-of-the-art. Here we propose and experimentally demonstrate an approach for performance enhancement that exploits the high level of similitude and redundancy contained on the multidimensional information measured by distributed fibre sensors. Exploiting conventional image and video processing, an unprecedented boost in signal-to-noise ratio and measurement contrast is experimentally demonstrated. The method can be applied to any white-noise-limited distributed fibre sensor and can remarkably provide a 100-fold improvement in the sensor performance with no hardware modification.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke (2019)

Karbasforoushan, Haleh ; Cohen-Adad, Julien ; Dewald, Julius P. A.

Springer Nature

In: Nature Communications. 2019; 10(1): 3524. Published 2019 Aug 06. doi: 10.1038/s41467-019-11244-3.

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Publication Date: 2019-08-06

Description: Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response (2018)

Szlachta, Karol ; Kuscu, Cem ; Tufan, Turan ; [et al.]

Springer Nature

In: Nature Communications. 2018; 9(1): 4275. Published 2018 Oct 15. doi: 10.1038/s41467-018-06676-2.

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Publication Date: 2018-10-15

Description: Predicting the response and identifying additional targets that will improve the efficacy of chemotherapy is a major goal in cancer research. Through large-scale in vivo and in vitro CRISPR knockout screens in pancreatic ductal adenocarcinoma cells, we identified genes whose genetic deletion or pharmacologic inhibition synergistically increase the cytotoxicity of MEK signaling inhibitors. Furthermore, we show that CRISPR viability scores combined with basal gene expression levels could model global cellular responses to the drug treatment. We develop drug response evaluation by in vivo CRISPR screening (DREBIC) method and validated its efficacy using large-scale experimental data from independent experiments. Comparative analyses demonstrate that DREBIC predicts drug response in cancer cells from a wide range of tissues with high accuracy and identifies therapeutic vulnerabilities of cancer-causing mutations to MEK inhibitors in various cancer types.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Age-dependent carry-over effects in a long-distance migratory bird (2019)

López Calderón, Cosme ; Balbontín Arenas, Javier ; Hobson, Keith A. ; [et al.]

Springer Nature

In: Scientific Reports. 2019; 9(1): 12032. Published 2019 Aug 19. doi: 10.1038/s41598-019-47374-3.

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Publication Date: 2019-08-19

Description: Migratory birds usually respond to climate change by modifying breeding and/or wintering areas, as well as by reproducing earlier. In addition, changes in winter habitat use or breeding phenology could have important carry-over effects on subsequent breeding success. Here, we studied age- and sex-dependent carry-over effects from wintering to the breeding stage of a small aerial insectivorous long-distance migratory bird, the barn swallows (Hirundo rustica) breeding in Denmark during 1984–2013. First, we used stable isotope analyses combined with ringing recoveries to identify wintering areas. Second, we found that environmental conditions as inferred by Normalized Difference Vegetation Index (NDVI) have improved at the wintering grounds. Third, we used confirmatory path analysis to quantify the indirect effect of winter conditions on subsequent breeding success. Males delayed onset of breeding and raised fewer fledglings in the first brood when ecological conditions during the previous winter improved. This response was age dependent, since yearlings did not respond to this environmental cue but the response was increasingly stronger as males aged. Females showed a similar response to winter conditions, although not statistically significant. These results highlight the importance of studying carry-over effects within the context of climate change, especially in relation to age of individuals.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Adaptable surfactant-mediated method for the preparation of anisotropic metal chalcogenide nanomaterials (2018)

McCarthy, S. A. ; Ratkic, R. ; Purcell-Milton, F. ; [et al.]

Springer Nature

In: Scientific Reports. 2018; 8(1): 2860. Published 2018 Feb 12. doi: 10.1038/s41598-018-21328-7.

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Publication Date: 2018-02-12

Description: The hot injection synthesis of nanomaterials is a highly diverse and fundamental field of chemical research, which has shown much success in the bottom up approach to nanomaterial design. Here we report a synthetic strategy for the production of anisotropic metal chalcogenide nanomaterials of different compositions and shapes, using an optimised hot injection approach. Its unique advantage compared to other hot injection routes is that it employs one chemical to act as many agents: high boiling point, viscous solvent, reducing agent, and surface coordinating ligand. It has been employed to produce a range of nanomaterials, such as CuS, Bi2S3, Cu2-xSe, FeSe2, and Bi4Se3, among others, with various structures including nanoplates and nanosheets. Overall, this article will highlight the excellent versatility of the method, which can be tuned to produce many different materials and shapes. In addition, due to the nature of the synthesis, 2D nanomaterial products are produced as monolayers without the need for exfoliation; a significant achievement towards future development of these materials.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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A simple and robust real-time qPCR method for the detection of PIK3CA mutations (2018)

Alvarez-Garcia, Virginia ; Bartos, Clare ; Keraite, Ieva ; [et al.]

Springer Nature

In: Scientific Reports. 2018; 8(1): 4290. Published 2018 Mar 09. doi: 10.1038/s41598-018-22473-9.

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Publication Date: 2018-03-09

Description: PIK3CA mutations are seemingly the most common driver mutations in breast cancer with H1047R and E545K being the most common of these, accounting together for around 60% of all PIK3CA mutations and have promising therapeutic implications. Given the low sensitivity and the high cost of current genotyping methods we sought to develop fast, simple and inexpensive assays for PIK3CA H1047R and E545K mutation screening in clinical material. The methods we describe are based on a real-time PCR including a mutation specific primer combined with a non-productive oligonucleotide which inhibits wild-type amplification and a parallel internal control reaction. We demonstrate consistent detection of PIK3CA H1047R mutant DNA in genomic DNA extracted from frozen breast cancer biopsies, FFPE material or cancer cell lines with a detection sensitivity of approximately 5% mutant allele fraction and validate these results using both Sanger sequencing and deep next generation sequencing methods. The detection sensitivity for PIK3CA E545K mutation was approximately 10%. We propose these methods as simple, fast and inexpensive diagnostic tools to determine PIK3CA mutation status.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Novel Hybrid Evolutionary Algorithms for Spatial Prediction of Floods (2018)

Bui, Dieu Tien ; Panahi, Mahdi ; Shahabi, Himan ; [et al.]

Springer Nature

In: Scientific Reports. 2018; 8(1): 15364. Published 2018 Oct 18. doi: 10.1038/s41598-018-33755-7.

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Publication Date: 2018-10-18

Description: Adaptive neuro-fuzzy inference system (ANFIS) includes two novel GIS-based ensemble artificial intelligence approaches called imperialistic competitive algorithm (ICA) and firefly algorithm (FA). This combination could result in ANFIS-ICA and ANFIS-FA models, which were applied to flood spatial modelling and its mapping in the Haraz watershed in Northern Province of Mazandaran, Iran. Ten influential factors including slope angle, elevation, stream power index (SPI), curvature, topographic wetness index (TWI), lithology, rainfall, land use, stream density, and the distance to river were selected for flood modelling. The validity of the models was assessed using statistical error-indices (RMSE and MSE), statistical tests (Friedman and Wilcoxon signed-rank tests), and the area under the curve (AUC) of success. The prediction accuracy of the models was compared to some new state-of-the-art sophisticated machine learning techniques that had previously been successfully tested in the study area. The results confirmed the goodness of fit and appropriate prediction accuracy of the two ensemble models. However, the ANFIS-ICA model (AUC = 0.947) had a better performance in comparison to the Bagging-LMT (AUC = 0.940), BLR (AUC = 0.936), LMT (AUC = 0.934), ANFIS-FA (AUC = 0.917), LR (AUC = 0.885) and RF (AUC = 0.806) models. Therefore, the ANFIS-ICA model can be introduced as a promising method for the sustainable management of flood-prone areas.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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High diversity stabilizes the thermal resilience of pollinator communities in intensively managed grasslands (2015)

Sara Kühsel; Nico Blüthgen

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article How variation in species responses to climate may influence the resilience of ecological communities to environmental change is not fully understood. Here, the authors characterize the thermal niches of insect pollinator communities and show that resilience increases along a gradient of land-use intensity. Nature Communications doi: 10.1038/ncomms8989 Authors: Sara Kühsel, Nico Blüthgen

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Oestrogen sulfotransferase ablation sensitizes mice to sepsis (2015)

Xiaojuan Chai; Yan Guo; Mengxi Jiang; Bingfang Hu; Zhigang Li; Jie Fan; Meihong Deng; Timothy R. Billiar; Heidi R. Kucera; Nilesh W. Gaikwad; Meishu Xu; Peipei Lu; Jiong Yan; Haiyan Fu; Youhua Liu; Lushan Yu; Min Huang; Su Zeng; Wen Xie

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article Sepsis, a systemic inflammatory response to bacterial infection, can lead to organ failure and death. Here, Chai et al. investigate the mechanisms behind the septic response and identify the role of oestrogen sulfotransferase in this process in mice. Nature Communications doi: 10.1038/ncomms8979 Authors: Xiaojuan Chai, Yan Guo, Mengxi Jiang, Bingfang Hu, Zhigang Li, Jie Fan, Meihong Deng, Timothy R. Billiar, Heidi R. Kucera, Nilesh W. Gaikwad, Meishu Xu, Peipei Lu, Jiong Yan, Haiyan Fu, Youhua Liu, Lushan Yu, Min Huang, Su Zeng, Wen Xie

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing (2015)

Kazutaka Nishina; Wenying Piao; Kie Yoshida-Tanaka; Yumiko Sujino; Tomoko Nishina; Tsuyoshi Yamamoto; Keiko Nitta; Kotaro Yoshioka; Hiroya Kuwahara; Hidenori Yasuhara; Takeshi Baba; Fumiko Ono; Kanjiro Miyata; Koichi Miyake; Punit P. Seth; Audrey Low; Masayuki Yoshida; C. Frank Bennett; Kazunori Kataoka; Hidehiro Mizusawa; Satoshi Obika; Takanori Yokota

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article Antisense oligonucleotides (ASOs) can repress the expression of specific genes. Here, the authors show that a DNA/RNA heteroduplex oligonucleotide (HDO) with a structure different from ASOs is more potent in suppressing target gene expression, and causes a less adverse effect in mouse liver. Nature Communications doi: 10.1038/ncomms8969 Authors: Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P. Seth, Audrey Low, Masayuki Yoshida, C. Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis (2015)

Uday Ganapathy; Joeli Marrero; Susannah Calhoun; Hyungjin Eoh; Luiz Pedro Sorio de Carvalho; Kyu Rhee; Sabine Ehrt

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article Mycobacterium tuberculosis feeds on host fatty acids during infection, a process that requires a fructose bisphosphatase (FBPase) enzyme for gluconeogenesis. Here, Ganapathy et al. show that the bacterium has two different FBPases and that this enzymatic activity is required for full virulence. Nature Communications doi: 10.1038/ncomms8912 Authors: Uday Ganapathy, Joeli Marrero, Susannah Calhoun, Hyungjin Eoh, Luiz Pedro Sorio de Carvalho, Kyu Rhee, Sabine Ehrt

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice (2015)

Joseph R. Burgoyne; Olena Rudyk; Hyun-ju Cho; Oleksandra Prysyazhna; Natasha Hathaway; Amanda Weeks; Rachel Evans; Tony Ng; Katrin Schröder; Ralf P. Brandes; Ajay M. Shah; Philip Eaton

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article The regulatory subunits (RI) of protein kinase A (PKA) form a disulfide bond in response to cellular hydrogen peroxide. Here the authors show that disulfide-activation of PKARIa regulates VEGF-induced angiogenesis in mice and may represent a new therapeutic target in diseases with abnormal angiogenesis. Nature Communications doi: 10.1038/ncomms8920 Authors: Joseph R. Burgoyne, Olena Rudyk, Hyun-ju Cho, Oleksandra Prysyazhna, Natasha Hathaway, Amanda Weeks, Rachel Evans, Tony Ng, Katrin Schröder, Ralf P. Brandes, Ajay M. Shah, Philip Eaton

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Experimental superposition of orders of quantum gates (2015)

Lorenzo M. Procopio; Amir Moqanaki; Mateus Araújo; Fabio Costa; Irati Alonso Calafell; Emma G. Dowd; Deny R. Hamel; Lee A. RozemaČaslav Brukner; Philip Walther

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-09

Description: Article It has been conjectured that not only states but also quantum operations can be placed in a superposition of causal order. Here, the authors use a qubit superpose the order in which two photonic gates are applied, which is shown to enable a more efficient detection of their commutation relations. Nature Communications doi: 10.1038/ncomms8913 Authors: Lorenzo M. Procopio, Amir Moqanaki, Mateus Araújo, Fabio Costa, Irati Alonso Calafell, Emma G. Dowd, Deny R. Hamel, Lee A. Rozema, Časlav Brukner, Philip Walther

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Coupling of individual quantum emitters to channel plasmons (2015)

Esteban Bermúdez-Ureña; Carlos Gonzalez-Ballestero; Michael Geiselmann; Renaud Marty; Ilya P. Radko; Tobias Holmgaard; Yury Alaverdyan; Esteban Moreno; Francisco J. García-Vidal; Sergey I. Bozhevolnyi; Romain Quidant

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-09

Description: Article The confined surface plasmon-polariton modes in plasmonic waveguides are a promising platform for single-photon manipulation in small, coplanar architectures. Here, Bermúdez Ureña et al . demonstrate efficient coupling of a single quantum emitter to the supported modes of a V-groove plasmonic waveguide. Nature Communications doi: 10.1038/ncomms8883 Authors: Esteban Bermúdez-Ureña, Carlos Gonzalez-Ballestero, Michael Geiselmann, Renaud Marty, Ilya P. Radko, Tobias Holmgaard, Yury Alaverdyan, Esteban Moreno, Francisco J. García-Vidal, Sergey I. Bozhevolnyi, Romain Quidant

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Diastereomeric liquid crystal domains at the mesoscale (2015)

Dong Chen; Michael R. Tuchband; Balazs Horanyi; Eva Korblova; David M. Walba; Matthew A. Glaser; Joseph E. Maclennan; Noel A. Clark

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-09

Description: Article Helical nanofilaments—composed of achiral, bent core molecules—have been shown to assemble into left- and right-handed structures. Here, the authors show diastereomeric interactions on the mesocale between chiral liquid crystal guest compounds and helical nanofilament-based pores. Nature Communications doi: 10.1038/ncomms8763 Authors: Dong Chen, Michael R. Tuchband, Balazs Horanyi, Eva Korblova, David M. Walba, Matthew A. Glaser, Joseph E. Maclennan, Noel A. Clark

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Nanometre-scale probing of spin waves using single-electron spins (2015)

Toeno van der Sar; Francesco Casola; Ronald Walsworth; Amir Yacoby

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-09

Description: Article Exploring magnetic excitations and spin textures on the nanoscale may lead to new spintronic technologies and new understanding of condensed matter. Here, the authors demonstrate the potential of single-electron spins in diamond to image such excitations by characterizing spin waves in a ferromagnetic microdisc. Nature Communications doi: 10.1038/ncomms8886 Authors: Toeno van der Sar, Francesco Casola, Ronald Walsworth, Amir Yacoby

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Superhydrophobic-like tunable droplet bouncing on slippery liquid interfaces (2015)

Chonglei Hao; Jing Li; Yuan Liu; Xiaofeng Zhou; Yahua Liu; Rong Liu; Lufeng Che; Wenzhong Zhou; Dong Sun; Lawrence Li; Lei Xu; Zuankai Wang

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-09

Description: Article The impact of drops on surfaces is highly relevant to our daily life and many industrial applications, such as self-cleaning and ink printing. Here, Hao et al . show the transition from superhydrophobic-like drop bouncing, due to a trapped air layer, to substrate-dependent bouncing on a liquid thin film. Nature Communications doi: 10.1038/ncomms8986 Authors: Chonglei Hao, Jing Li, Yuan Liu, Xiaofeng Zhou, Yahua Liu, Rong Liu, Lufeng Che, Wenzhong Zhou, Dong Sun, Lawrence Li, Lei Xu, Zuankai Wang

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Improved binding site assignment by high-resolution mapping of RNA–protein interactions using iCLIP (2015)

Christian Hauer; Tomaz Curk; Simon Anders; Thomas Schwarzl; Anne-Marie Alleaume; Jana Sieber; Ina Hollerer; Madhuri Bhuvanagiri; Wolfgang Huber; Matthias W. Hentze; Andreas E. Kulozik

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article Individual-nucleotide resolution crosslinking and immunoprecipitation (iCLIP) can map RNA binding sites of RNA-binding proteins (RBPs). Here, the authors report an analysis tool that improves the binding site assignment for some RBPs that have length-dependent broader distribution for their iCLIP fragments. Nature Communications doi: 10.1038/ncomms8921 Authors: Christian Hauer, Tomaz Curk, Simon Anders, Thomas Schwarzl, Anne-Marie Alleaume, Jana Sieber, Ina Hollerer, Madhuri Bhuvanagiri, Wolfgang Huber, Matthias W. Hentze, Andreas E. Kulozik

Electronic ISSN: 2041-1723

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IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis (2015)

Rei Nakamura; Abdoulaye Sene; Andrea Santeford; Abdelaziz Gdoura; Shunsuke Kubota; Nicole Zapata; Rajendra S. Apte

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article Pathological neovascularization causes blinding eye disease. Here the authors show that IL10 activates STAT3 signalling in the macrophages in the ageing eye, promoting their polarization towards a pro-angiogenic phenotype; interfering with this pathway reverses the pathology in a mouse model. Nature Communications doi: 10.1038/ncomms8847 Authors: Rei Nakamura, Abdoulaye Sene, Andrea Santeford, Abdelaziz Gdoura, Shunsuke Kubota, Nicole Zapata, Rajendra S. Apte

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Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella (2015)

Adrien Sicard; Christian Kappel; Emily B. Josephs; Young Wha Lee; Cindy Marona; John R. Stinchcombe; Stephen I. Wright; Michael Lenhard

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-15

Description: Article A hybrid incompatibility between Capsella plant species is due to an interaction between two immune regulators. Here, the authors show that highly divergent haplotypes result from balancing selection in the ancestral lineage and their sorting into derived lineages facilitated the evolution of the incompatibility. Nature Communications doi: 10.1038/ncomms8960 Authors: Adrien Sicard, Christian Kappel, Emily B. Josephs, Young Wha Lee, Cindy Marona, John R. Stinchcombe, Stephen I. Wright, Michael Lenhard

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Mapping molecules in scanning far-field fluorescence nanoscopy (2015)

Haisen Ta; Jan Keller; Markus Haltmeier; Sinem K. Saka; Jürgen Schmied; Felipe Opazo; Philip Tinnefeld; Axel Munk; Stefan W. Hell

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-15

Description: Article Mapping the distribution of fluorescence molecules, rather than just their emission intensity, can improve super-resolution fluorescence microscopy. Here, the authors present a general solution for rendering the number of fluorescent molecules recorded by confocal or STED microscopy. Nature Communications doi: 10.1038/ncomms8977 Authors: Haisen Ta, Jan Keller, Markus Haltmeier, Sinem K. Saka, Jürgen Schmied, Felipe Opazo, Philip Tinnefeld, Axel Munk, Stefan W. Hell

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Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help (2015)

Juhyun Kim; Su Jeong Ryu; Keunhee Oh; Ji-Min Ju; Ji Yeong Jeon; Giri Nam; Dong-Sup Lee; Hang-Rae Kim; Joo Young Kim; Jun Chang; Thomas Sproule; Kyungho Choi; Derry Roopenian; Eun Young Choi

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article Persistent antigen stimulation can cause exhaustion and unresponsiveness of CD8 cells, impairing the immune response. Here the authors show that increasing the number of CD8 cells, decreasing the antigen load or providing CD4 help can overcome the exhaustion and establish a memory response. Nature Communications doi: 10.1038/ncomms8994 Authors: Juhyun Kim, Su Jeong Ryu, Keunhee Oh, Ji-Min Ju, Ji Yeong Jeon, Giri Nam, Dong-Sup Lee, Hang-Rae Kim, Joo Young Kim, Jun Chang, Thomas Sproule, Kyungho Choi, Derry Roopenian, Eun Young Choi

Electronic ISSN: 2041-1723

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Absorption-induced scattering and surface plasmon out-coupling from absorber-coated plasmonic metasurfaces (2015)

Christopher E. Petoukhoff; Deirdre M. O’Carroll

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article Plasmonic surfaces are used as two-dimensional metamaterials for light manipulation on nanoscale, and their optical properties can be further tuned by coating. Here the authors report a new absorption-induced scattering mode in a silver nanoparticle array coated with semiconducting organic absorbers. Nature Communications doi: 10.1038/ncomms8899 Authors: Christopher E. Petoukhoff, Deirdre M. O’Carroll

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Tectonic control on the persistence of glacially sculpted topography (2015)

Günther Prasicek; Isaac J. Larsen; David R. Montgomery

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article U-shaped glacial valleys dominate 〉10 ka since the last major glaciation and the transitions from glacier-dominated to fluvial regimes are poorly understood. Here, the authors use digital topographic data to show that glacial topography is rapidly replaced by fluvial topography where rock uplift rates are high. Nature Communications doi: 10.1038/ncomms9028 Authors: Günther Prasicek, Isaac J. Larsen, David R. Montgomery

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Conformational states of the full-length glucagon receptor (2015)

Linlin Yang; Dehua Yang; Chris de Graaf; Arne Moeller; Graham M. West; Venkatasubramanian Dharmarajan; Chong Wang; Fai Y. Siu; Gaojie Song; Steffen Reedtz-Runge; Bruce D. Pascal; Beili Wu; Clinton S. Potter; Hu Zhou; Patrick R. Griffin; Bridget Carragher; Huaiyu Yang; Ming-Wei Wang; Raymond C. Stevens; Hualiang Jiang

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-02

Description: Article G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in humans and exhibit diverse activation mechanisms. Here, the authors combine electron microscopy, hydrogen deuterium exchange and Molecular dynamics simulations to gain insight into the activation mechanism of the glucagon receptor. Nature Communications doi: 10.1038/ncomms8859 Authors: Linlin Yang, Dehua Yang, Chris de Graaf, Arne Moeller, Graham M. West, Venkatasubramanian Dharmarajan, Chong Wang, Fai Y. Siu, Gaojie Song, Steffen Reedtz-Runge, Bruce D. Pascal, Beili Wu, Clinton S. Potter, Hu Zhou, Patrick R. Griffin, Bridget Carragher, Huaiyu Yang, Ming-Wei Wang, Raymond C. Stevens, Hualiang Jiang

Electronic ISSN: 2041-1723

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Single-atom electron energy loss spectroscopy of light elements (2015)

Ryosuke Senga; Kazu Suenaga

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-02

Description: Article Light atoms are hardly visible through standard microscopy techniques, because of their smaller scattering power and higher knock-on probability. Here, the authors present an approach to probe light atoms by means of electron energy loss spectroscopy, relying on inelastically scattered electrons. Nature Communications doi: 10.1038/ncomms8943 Authors: Ryosuke Senga, Kazu Suenaga

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Evaluation of candidate vaccine approaches for MERS-CoV (2015)

Lingshu Wang; Wei Shi; M. Gordon Joyce; Kayvon Modjarrad; Yi Zhang; Kwanyee Leung; Christopher R. Lees; Tongqing Zhou; Hadi M. Yassine; Masaru Kanekiyo; Zhi-yong Yang; Xuejun Chen; Michelle M. Becker; Megan Freeman; Leatrice Vogel; Joshua C. Johnson; Gene Olinger; John P. Todd; Ulas Bagci; Jeffrey Solomon; Daniel J. Mollura; Lisa Hensley; Peter Jahrling; Mark R. Denison; Srinivas S. Rao; Kanta Subbarao; Peter D. Kwong; John R. Mascola; Wing-Pui Kong; Barney S. Graham

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Unmet need exists for a vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV). Here the authors report the establishment and evaluation, in mice and primates, of a series of MERS-CoV immunogens and show that they can serve as promising leads for vaccine development. Nature Communications doi: 10.1038/ncomms8712 Authors: Lingshu Wang, Wei Shi, M. Gordon Joyce, Kayvon Modjarrad, Yi Zhang, Kwanyee Leung, Christopher R. Lees, Tongqing Zhou, Hadi M. Yassine, Masaru Kanekiyo, Zhi-yong Yang, Xuejun Chen, Michelle M. Becker, Megan Freeman, Leatrice Vogel, Joshua C. Johnson, Gene Olinger, John P. Todd, Ulas Bagci, Jeffrey Solomon, Daniel J. Mollura, Lisa Hensley, Peter Jahrling, Mark R. Denison, Srinivas S. Rao, Kanta Subbarao, Peter D. Kwong, John R. Mascola, Wing-Pui Kong, Barney S. Graham

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Stabilization of 4H hexagonal phase in gold nanoribbons (2015)

Zhanxi Fan; Michel Bosman; Xiao Huang; Ding Huang; Yi Yu; Khuong P. Ong; Yuriy A. Akimov; Lin Wu; Bing Li; Jumiati Wu; Ying Huang; Qing Liu; Ching Eng Png; Chee Lip Gan; Peidong Yang; Hua Zhang

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Noble metals typically crystallize with the face-centered cubic structure. Here, the authors report the synthesis of gold nanoribbons in the 4H hexagonal polytype, a previously unreported, metastable phase of gold, and use it to stabilize 4H hexagonal phases of silver, palladium and platinum. Nature Communications doi: 10.1038/ncomms8684 Authors: Zhanxi Fan, Michel Bosman, Xiao Huang, Ding Huang, Yi Yu, Khuong P. Ong, Yuriy A. Akimov, Lin Wu, Bing Li, Jumiati Wu, Ying Huang, Qing Liu, Ching Eng Png, Chee Lip Gan, Peidong Yang, Hua Zhang

Electronic ISSN: 2041-1723

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Observation of non-Markovian micromechanical Brownian motion (2015)

S. Gröblacher; A. Trubarov; N. Prigge; G. D. Cole; M. Aspelmeyer; J. Eisert

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article All quantum systems are connected to their environment, and this reduces their quantumness through decoherence. Here, the authors show that the interaction between a macroscale quantum system—a micromechanical oscillator—and its environment leads to non-Markovian Brownian motion Nature Communications doi: 10.1038/ncomms8606 Authors: S. Gröblacher, A. Trubarov, N. Prigge, G. D. Cole, M. Aspelmeyer, J. Eisert

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Aversive learning shapes neuronal orientation tuning in human visual cortex (2015)

Lisa M. McTeague; L. Forest Gruss; Andreas Keil

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Sensory cortical tuning is shaped by experience to facilitate coding of features that are predictive of behaviourally relevant outcomes. Here the authors demonstrate that rapid behaviourally driven retuning of human visual cortex involves top–down projections as well as local inhibitory interactions. Nature Communications doi: 10.1038/ncomms8823 Authors: Lisa M. McTeague, L. Forest Gruss, Andreas Keil

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MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex (2015)

Kyung Yong Lee; Jun-Sub Im; Etsuko Shibata; Jonghoon Park; Naofumi Handa; Stephen C. Kowalczykowski; Anindya Dutta

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article The MCM8-9 complex is required for repair of DNA double-strand breaks (DSBs). Here, the authors show that MCM8-9 is required for the nuclease activity of the MRE11-RAD50-NBS1 complex (MRN) and stabilizes its association with DNA damage sites, promoting resection of DSB ends. Nature Communications doi: 10.1038/ncomms8744 Authors: Kyung Yong Lee, Jun-Sub Im, Etsuko Shibata, Jonghoon Park, Naofumi Handa, Stephen C. Kowalczykowski, Anindya Dutta

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Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52 (2015)

William A. Gaines; Stephen K. Godin; Faiz F. Kabbinavar; Timsi Rao; Andrew P. Van; Demark; Patrick Sung; Kara A. Bernstein

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Homologous repair of DNA double strand breaks in Saccharomyces cerevisiae is dependent on several conserved Rad51 paralogs. Here the authors provide biochemical evidence that Rad55-Rad57 synergistically interacts with the Shu complex to promote Rad51 filament formation and homology directed repair. Nature Communications doi: 10.1038/ncomms8834 Authors: William A. Gaines, Stephen K. Godin, Faiz F. Kabbinavar, Timsi Rao, Andrew P. VanDemark, Patrick Sung, Kara A. Bernstein

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Phytochrome diversity in green plants and the origin of canonical plant phytochromes (2015)

Fay-Wei Li; Michael Melkonian; Carl J. Rothfels; Juan Carlos Villarreal; Dennis W. Stevenson; Sean W. Graham; Gane Ka-Shu Wong; Kathleen M. Pryer; Sarah Mathews

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Phytochromes are red-light photoreceptors in plants that regulate key life cycle processes, yet their evolutionary origins are not well understood. Using transcriptomic and genomic data, Li et al. find that canonical plant phytochromes originated in a common ancestor of land plants and charophyte algae. Nature Communications doi: 10.1038/ncomms8852 Authors: Fay-Wei Li, Michael Melkonian, Carl J. Rothfels, Juan Carlos Villarreal, Dennis W. Stevenson, Sean W. Graham, Gane Ka-Shu Wong, Kathleen M. Pryer, Sarah Mathews

Electronic ISSN: 2041-1723

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Quantum Monte Carlo study of the phase diagram of solid molecular hydrogen at extreme pressures (2015)

N. D. Drummond; Bartomeu Monserrat; Jonathan H. Lloyd-Williams; P. López Ríos; Chris J. Pickard; R. J. Needs

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article Experimental studies of hydrogen at high pressure are challenging, so theory is central to understanding its phase behaviour; however, computed phase diagrams do not agree with previous measurements. Here, the authors use a quantum Monte Carlo method and present results in qualitative agreement with experiment. Nature Communications doi: 10.1038/ncomms8794 Authors: N. D. Drummond, Bartomeu Monserrat, Jonathan H. Lloyd-Williams, P. López Ríos, Chris J. Pickard, R. J. Needs

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Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation (2015)

F. S. Ruggeri; G. Longo; S. Faggiano; E. Lipiec; A. Pastore; G. Dietler

Springer Nature

In: Nature Communications

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Publication Date: 2015-07-30

Description: Article The onset of neurodegenerative disorders is associated at the molecular level with insoluble protein aggregates, named amyloids. Here, the authors characterize by infrared nanospectroscopy and nanomechanical studies, the amyloid aggregation at the individual species scale. Nature Communications doi: 10.1038/ncomms8831 Authors: F. S. Ruggeri, G. Longo, S. Faggiano, E. Lipiec, A. Pastore, G. Dietler

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Negative emissions physically needed to keep global warming below 2 °C (2015)

T. Gasser; C. Guivarch; K. Tachiiri; C. D. Jones; P. Ciais

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article It is widely acknowledged that some form of carbon capture will be necessary to limit global warming to less than 2 °C, but to what extent remains unclear. Here, using climate-carbon models, the authors quantify the amount of negative emissions and carbon storage capacity required to meet this target. Nature Communications doi: 10.1038/ncomms8958 Authors: T. Gasser, C. Guivarch, K. Tachiiri, C. D. Jones, P. Ciais

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An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer (2015)

D. M. Janzen; E. Tiourin; J. A. Salehi; D. Y. Paik; J. Lu; M. Pellegrini; S. Memarzadeh

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Despite normalization of the CA125 serum biomarker at the completion of carboplatin therapy the vast majority of patients with high grade serous ovarian cancers relapse. Here, Janzen et al ., identify a sub-population of tumor cells that are CA125 negative, cancer initiating and platinum resistant but readily eliminated with the addition of apoptosis enhancing drugs to carboplatin. Nature Communications doi: 10.1038/ncomms8956 Authors: D. M. Janzen, E. Tiourin, J. A. Salehi, D. Y. Paik, J. Lu, M. Pellegrini, S. Memarzadeh

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The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins (2015)

Amy E. M. Beedle; Ainhoa Lezamiz; Guillaume Stirnemann; Sergi Garcia-Manyes

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article In metalloproteins, a metal cofactor participates in the formation of the correct fold. Here the authors demonstrate—using single molecule force spectroscopy and the native copper centre as an embedded internal reporter—that the blue-copper proteins azurin and plastocyanin unfold via two independent competing pathways under force. Nature Communications doi: 10.1038/ncomms8894 Authors: Amy E. M. Beedle, Ainhoa Lezamiz, Guillaume Stirnemann, Sergi Garcia-Manyes

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Detection of entanglement in asymmetric quantum networks and multipartite quantum steering (2015)

D. Cavalcanti; P. Skrzypczyk; G. H. Aguilar; R. V. Nery; P.H. Souto Ribeiro; S. P. Walborn

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Quantum communications operate with shared multipartite entangled states, and this has to be certified in a setting where not all parties are trusted in the same way. Here the authors propose a method to certify multipartite entanglement in asymmetric scenarios and demonstrate it in an optical experiment. Nature Communications doi: 10.1038/ncomms8941 Authors: D. Cavalcanti, P. Skrzypczyk, G. H. Aguilar, R. V. Nery, P.H. Souto Ribeiro, S. P. Walborn

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Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex (2015)

Oriana S. Fisher; Hanqiang Deng; Dou Liu; Ya Zhang; Rong Wei; Yong Deng; Fan Zhang; Angeliki Louvi; Benjamin E. Turk; Titus J. Boggon; Bing Su

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article The protein kinase MEKK3 interacts with CCM2, which is associated with the predominantly cerebrovascular CCM disease. Here the authors use structural, biochemical, cell biology and in vivo techniques to show that regulation of Rho signalling by the CCM2:MEKK3 complex is needed to maintain neurovascular integrity. Nature Communications doi: 10.1038/ncomms8937 Authors: Oriana S. Fisher, Hanqiang Deng, Dou Liu, Ya Zhang, Rong Wei, Yong Deng, Fan Zhang, Angeliki Louvi, Benjamin E. Turk, Titus J. Boggon, Bing Su

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Flexible lithium–oxygen battery based on a recoverable cathode (2015)

Qing-Chao Liu; Ji-Jing Xu; Dan Xu; Xin-Bo Zhang

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Flexible energy storage systems usually have limited energy densities. Here the authors report a flexible lithium–oxygen battery with the cathode consisting of titanium dioxide nanowire arrays grown on carbon textiles, which displays high mechanical strength as well as promising electrochemical performance. Nature Communications doi: 10.1038/ncomms8892 Authors: Qing-Chao Liu, Ji-Jing Xu, Dan Xu, Xin-Bo Zhang

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Large-volume en-bloc staining for electron microscopy-based connectomics (2015)

Yunfeng Hua; Philip Laserstein; Moritz Helmstaedter

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Large-scale dense reconstruction of neuronal circuits (or connectomics) requires methods for large-volume dense en-bloc electron microscopy (EM) staining. Here the authors develop a protocol for staining tissue blocks from mouse neocortex sized at least 1 mm in diameter, enabling correlated functional and structural circuit analyses. Nature Communications doi: 10.1038/ncomms8923 Authors: Yunfeng Hua, Philip Laserstein, Moritz Helmstaedter

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Unlocking the energy capabilities of micron-sized LiFePO4 (2015)

Limin Guo; Yelong Zhang; Jiawei Wang; Lipo Ma; Shunchao Ma; Yantao Zhang; Erkang Wang; Yujing Bi; Deyu Wang; William C. McKee; Ye Xu; Jitao Chen; Qinghua Zhang; Cewen Nan; Lin Gu; Peter G. Bruce; Zhangquan Peng

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Nanonization of battery electrode particles is a usual way to enhance their conductivity, but the decreased tap density is detrimental to battery performance. Here, the authors coat micron-sized lithium iron phosphate with a conducting polymer layer and demonstrate some excellent electrochemical properties. Nature Communications doi: 10.1038/ncomms8898 Authors: Limin Guo, Yelong Zhang, Jiawei Wang, Lipo Ma, Shunchao Ma, Yantao Zhang, Erkang Wang, Yujing Bi, Deyu Wang, William C. McKee, Ye Xu, Jitao Chen, Qinghua Zhang, Cewen Nan, Lin Gu, Peter G. Bruce, Zhangquan Peng

Electronic ISSN: 2041-1723

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Hail formation triggers rapid ash aggregation in volcanic plumes (2015)

Alexa R. Van Eaton; Larry G. Mastin; Michael Herzog; Hans F. Schwaiger; David J. Schneider; Kristi L. Wallace; Amanda B. Clarke

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article The behaviour of airborne fine ash during explosive volcanic eruptions is poorly understood. Here, the authors study hail formation during an eruption, proposing a mechanism of particle aggregation that leads to the fallout of fine ash and the occurrence of concentrically layered aggregates in volcanic deposits Nature Communications doi: 10.1038/ncomms8860 Authors: Alexa R. Van Eaton, Larry G. Mastin, Michael Herzog, Hans F. Schwaiger, David J. Schneider, Kristi L. Wallace, Amanda B. Clarke

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Climate-mediated diversification of turtles in the Cretaceous (2015)

David B. Nicholson; Patricia A. Holroyd; Roger B. J. Benson; Paul M. Barrett

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-05

Description: Article Turtles are ectothermic vertebrates that have experienced major environmental perturbations. Here the authors show that the geographical distribution of turtles was mediated by climate throughout the Mezozoic and show an increase in diversity of non-marine turtles starting in the Early Cretaceous. Nature Communications doi: 10.1038/ncomms8848 Authors: David B. Nicholson, Patricia A. Holroyd, Roger B. J. Benson, Paul M. Barrett

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Unique metabolites protect earthworms against plant polyphenols (2015)

Manuel Liebeke; Nicole Strittmatter; Sarah Fearn; A. John Morgan; Peter Kille; Jens Fuchser; David Wallis; Vitalii Palchykov; Jeremy Robertson; Elma Lahive; David J. Spurgeon; David McPhail; Zoltán Takáts; Jacob G. Bundy

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In: Nature Communications

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Publication Date: 2015-08-06

Description: Article Little is known about how detritivorous invertebrates cope with high levels of defensive plant polyphenols. Here, Liebeke et al . identify a new class of surface-active metabolites in earthworms exposed to high-polyphenol diets, and show that they play a protective role against precipitation of proteins. Nature Communications doi: 10.1038/ncomms8869 Authors: Manuel Liebeke, Nicole Strittmatter, Sarah Fearn, A. John Morgan, Peter Kille, Jens Fuchser, David Wallis, Vitalii Palchykov, Jeremy Robertson, Elma Lahive, David J. Spurgeon, David McPhail, Zoltán Takáts, Jacob G. Bundy

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Rescue of long-term memory after reconsolidation blockade (2015)

Simon Trent; Philip Barnes; Jeremy Hall; Kerrie L. Thomas

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-06

Description: Article Recalled memories enter a labile state and are thought to be restabilized through reconsolidation. Here, the authors challenge the long-held notion that reconsolidation is a distinct memory process and demonstrate that the molecular events initiated at recall act instead to constrain premature extinction. Nature Communications doi: 10.1038/ncomms8897 Authors: Simon Trent, Philip Barnes, Jeremy Hall, Kerrie L. Thomas

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Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling (2015)

Tsunaki Hongu; Yuji Funakoshi; Shigetomo Fukuhara; Teruhiko Suzuki; Susumu Sakimoto; Nobuyuki Takakura; Masatsugu Ema; Satoru Takahashi; Susumu Itoh; Mitsuyasu Kato; Hiroshi Hasegawa; Naoki Mochizuki; Yasunori Kanaho

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In: Nature Communications

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Publication Date: 2015-08-06

Description: Article Targetting tumour angiogenesis is a useful strategy to reduce tumour burden; however, the clinical benefits of anti-angiogenetic drugs are modest. Here, the authors show that HGFR signalling, which contributes to tumour angiogenesis, requires Arf6 and that blocking Arf6 can lead to reduced tumour growth in mice. Nature Communications doi: 10.1038/ncomms8925 Authors: Tsunaki Hongu, Yuji Funakoshi, Shigetomo Fukuhara, Teruhiko Suzuki, Susumu Sakimoto, Nobuyuki Takakura, Masatsugu Ema, Satoru Takahashi, Susumu Itoh, Mitsuyasu Kato, Hiroshi Hasegawa, Naoki Mochizuki, Yasunori Kanaho

Electronic ISSN: 2041-1723

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 (2015)

Megan Carter; Ann-Sofie Jemth; Anna Hagenkort; Brent D. G. Page; Robert Gustafsson; Julia J. Griese; Helge Gad; Nicholas C. K. Valerie; Matthieu Desroses; Johan Boström; Ulrika Warpman Berglund; Thomas Helleday; Pål Stenmark

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In: Nature Communications

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Publication Date: 2015-08-06

Description: Article Dysfunctional redox regulation in cancer can damage dNTPs so inhibiting dNTP pool sanitizing enzymes, such as MTH1, is a potential cancer treatment. Here, Carter et al. characterize MTH2 (NUDT15) and show that it is not a dNTP sanitizer, and so is unlikely to influence the efficacy of MTH1 inhibitors. Nature Communications doi: 10.1038/ncomms8871 Authors: Megan Carter, Ann-Sofie Jemth, Anna Hagenkort, Brent D. G. Page, Robert Gustafsson, Julia J. Griese, Helge Gad, Nicholas C. K. Valerie, Matthieu Desroses, Johan Boström, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark

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Non-plasmonic nanoantennas for surface enhanced spectroscopies with ultra-low heat conversion (2015)

Martín Caldarola; Pablo Albella; Emiliano Cortés; Mohsen Rahmani; Tyler Roschuk; Gustavo Grinblat; Rupert F. Oulton; Andrea V. Bragas; Stefan A. Maier

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In: Nature Communications

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Publication Date: 2015-08-06

Description: Article Metallic nanoantennas can enhance and confine electromagnetic fields, however, localized heating hinders many applications. Here, Caldarola et al. demonstrate both high near-field enhancement and ultra-low heat conversion in the visible-near infrared region using silicon dimer nanoantennas with 20 nm gaps. Nature Communications doi: 10.1038/ncomms8915 Authors: Martín Caldarola, Pablo Albella, Emiliano Cortés, Mohsen Rahmani, Tyler Roschuk, Gustavo Grinblat, Rupert F. Oulton, Andrea V. Bragas, Stefan A. Maier

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Mode-selective vibrational modulation of charge transport in organic electronic devices (2015)

Artem A. Bakulin; Robert Lovrincic; Xi Yu; Oleg Selig; Huib J. Bakker; Yves L. A. Rezus; Pabitra K. Nayak; Alexandr Fonari; Veaceslav Coropceanu; Jean-Luc Brédas; David Cahen

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In: Nature Communications

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Publication Date: 2015-08-08

Description: Article The electronic properties of organic molecules are sensitive to structural dynamics, but device control through this phenomenon has not been attained. Bakulin et al . show that the photoconductivity can be modulated by selective excitation of molecular vibrations in an organic optoelectronic device. Nature Communications doi: 10.1038/ncomms8880 Authors: Artem A. Bakulin, Robert Lovrincic, Xi Yu, Oleg Selig, Huib J. Bakker, Yves L. A. Rezus, Pabitra K. Nayak, Alexandr Fonari, Veaceslav Coropceanu, Jean-Luc Brédas, David Cahen

Electronic ISSN: 2041-1723

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MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation (2015)

Julia R. Pon; Jackson Wong; Saeed Saberi; Olivia Alder; Michelle Moksa; S. -W. Grace Cheng; Gregg B. Morin; Pamela A. Hoodless; Martin Hirst; Marco A. Marra

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In: Nature Communications

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Publication Date: 2015-08-08

Description: Article Mutations in the transcription factor MEF2B are found in diffuse large B-cell lymphoma. In this study, the authors map the DNA-binding sites of the transcription factor in cells in vitro and find that the mutations decrease the ability of MEF2B to activate transcription. Nature Communications doi: 10.1038/ncomms8953 Authors: Julia R. Pon, Jackson Wong, Saeed Saberi, Olivia Alder, Michelle Moksa, S. -W. Grace Cheng, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst, Marco A. Marra

Electronic ISSN: 2041-1723

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Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity (2015)

Donald A. Winkelmann; Eva Forgacs; Matthew T. Miller; Ann M. Stock

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-08

Description: Article Omecamtiv Mecarbil (OM) is a small molecule allosteric effector of cardiac myosin in clinical trials for treatment of systolic heart failure. Here the authors determine the crystal structure of an OM-bound human β-cardiac myosin motor domain to provide molecular level insight into the mechanism of drug action. Nature Communications doi: 10.1038/ncomms8974 Authors: Donald A. Winkelmann, Eva Forgacs, Matthew T. Miller, Ann M. Stock

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Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription (2015)

Mihue Jang; Jong Hwan Kim; Hae Yun Nam; Ick Chan Kwon; Hyung Jun Ahn

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-08

Description: Article RNA interference has provided a promising tool to suppress the expression of specific genes associated with human diseases. Here, the authors present a platform technology for the systemic delivery of siRNA to tumour sites using rolling circle transcription. Nature Communications doi: 10.1038/ncomms8930 Authors: Mihue Jang, Jong Hwan Kim, Hae Yun Nam, Ick Chan Kwon, Hyung Jun Ahn

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Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications (2015)

Fuyao Liu; Xiuxia He; Hongda Chen; Junping Zhang; Huimao Zhang; Zhenxin Wang

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-08

Description: Article Coordination polymers are promising drug delivery nanomaterials as their structural properties can be easily controlled. Here, Wang et al . prepare coordination nanodots that integrate cancer imaging and therapeutic functions with beneficial renal clearance. Nature Communications doi: 10.1038/ncomms9003 Authors: Fuyao Liu, Xiuxia He, Hongda Chen, Junping Zhang, Huimao Zhang, Zhenxin Wang

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Inhibition of stationary phase respiration impairs persister formation in E. coli (2015)

Mehmet A. Orman; Mark P. Brynildsen

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-08

Description: Article A few bacterial cells within a genetically homogeneous population can become ‘persisters’, or temporarily tolerant to antibiotics. Here Orman and Brynildsen show that development of persisters among growth-arrested E. coli cells can be prevented by inhibiting bacterial respiration. Nature Communications doi: 10.1038/ncomms8983 Authors: Mehmet A. Orman, Mark P. Brynildsen

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Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries (2015)

Joana A. Vidigal; Andrea Ventura

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In: Nature Communications

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Publication Date: 2015-08-19

Description: Article CRISPR-Cas9 is a powerful tool for genome editing; however, difficulties in generating pools of paired guide RNAs limit its applicability to large-scale screening experiments. Here the authors report a one-step method for rapid and efficient generation of pooled libraries of guide RNA pairs. Nature Communications doi: 10.1038/ncomms9083 Authors: Joana A. Vidigal, Andrea Ventura

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Cell shape dynamics during the staphylococcal cell cycle (2015)

João M. Monteiro; Pedro B. Fernandes; Filipa Vaz; Ana R. Pereira; Andreia C. Tavares; Maria T. Ferreira; Pedro M. Pereira; Helena Veiga; Erkin Kuru; Michael S. Van; Nieuwenhze; Yves V. Brun; Sérgio R. Filipe; Mariana G. Pinho

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In: Nature Communications

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Publication Date: 2015-08-19

Description: Article Staphylococci are spherical bacteria that divide in sequential orthogonal planes. Here, the authors use super-resolution microscopy to show that staphylococcal cells elongate before dividing, and that the division septum generates less than one hemisphere of each daughter cell, generating asymmetry. Nature Communications doi: 10.1038/ncomms9055 Authors: João M. Monteiro, Pedro B. Fernandes, Filipa Vaz, Ana R. Pereira, Andreia C. Tavares, Maria T. Ferreira, Pedro M. Pereira, Helena Veiga, Erkin Kuru, Michael S. VanNieuwenhze, Yves V. Brun, Sérgio R. Filipe, Mariana G. Pinho

Electronic ISSN: 2041-1723

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Batf is important for IL-4 expression in T follicular helper cells (2015)

Anupama Sahoo; Andrei Alekseev; Kentaro Tanaka; Lidiya Obertas; Beatrisa Lerman; Cara Haymaker; Karen Clise-Dwyer; John S. McMurray; Roza Nurieva

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-19

Description: Article T follicular helper cells are a distinct subtype of CD4 T helper cells, which contributes to the regulation of type 2 humoral immunity by producing IL-4. Here, the authors identify Batf as an important transcription factor regulating IL-4 expression in T follicular helper cells but not in Th2 cells. Nature Communications doi: 10.1038/ncomms8997 Authors: Anupama Sahoo, Andrei Alekseev, Kentaro Tanaka, Lidiya Obertas, Beatrisa Lerman, Cara Haymaker, Karen Clise-Dwyer, John S. McMurray, Roza Nurieva

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Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations (2015)

M. Geoffrey Hayes; Margrit Urbanek; David A. Ehrmann; Loren L. Armstrong; Ji Young Lee; Ryan Sisk; Tugce Karaderi; Thomas M. Barber; Mark I. McCarthy; Stephen Franks; Cecilia M. Lindgren; Corrine K. Welt; Evanthia Diamanti-Kandarakis; Dimitrios Panidis; Mark O. Goodarzi; Ricardo Azziz; Yi Zhang; Roland G. James; Michael Olivier; Ahmed H. Kissebah; Elisabet Stener-Victorin; Richard S. Legro; Andrea Dunaif

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-20

Description: Article Polycystic Ovary Sydrome is a highly heritable, complex reproductive disorder with unknown underlying genetic factors. Here Hayes and Urbanek et al . identify three loci in European women strongly associated with neuroendocrine changes and disease susceptibility. Nature Communications doi: 10.1038/ncomms8502 Authors: M. Geoffrey Hayes, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M. Barber, Mark I. McCarthy, Stephen Franks, Cecilia M. Lindgren, Corrine K. Welt, Evanthia Diamanti-Kandarakis, Dimitrios Panidis, Mark O. Goodarzi, Ricardo Azziz, Yi Zhang, Roland G. James, Michael Olivier, Ahmed H. Kissebah, Elisabet Stener-Victorin, Richard S. Legro, Andrea Dunaif

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Habitat changes and changing predatory habits in North American fossil canids (2015)

B. Figueirido; A. Martín-Serra; Z. J. Tseng; C. M. Janis

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In: Nature Communications

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Publication Date: 2015-08-20

Description: Article Changes in vegetation can influence the evolution of morphology and behaviour. Here the authors show an association between elbow-joint shape and habitat for North American canids over the past ∼37 million years, which suggests that climate change can influence the evolution of predatory behaviour. Nature Communications doi: 10.1038/ncomms8976 Authors: B. Figueirido, A. Martín-Serra, Z. J. Tseng, C. M. Janis

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Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting (2015)

Munitta Muthana; Aneurin J. Kennerley; Russell Hughes; Ester Fagnano; Jay Richardson; Melanie Paul; Craig Murdoch; Fiona Wright; Christopher Payne; Mark F. Lythgoe; Neil Farrow; Jon Dobson; Joe Conner; Jim M. Wild; Claire Lewis

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-20

Description: Article Cell therapy requires the targeting of cells to specific sites in the body. Here Muthana et al. use a standard MRI scanner to direct oncolytic macrophages, labelled with magnetic nanoparticles, to primary and metastatic tumour sites in mice, and demonstrate that this leads to reduced tumour growth. Nature Communications doi: 10.1038/ncomms9009 Authors: Munitta Muthana, Aneurin J. Kennerley, Russell Hughes, Ester Fagnano, Jay Richardson, Melanie Paul, Craig Murdoch, Fiona Wright, Christopher Payne, Mark F. Lythgoe, Neil Farrow, Jon Dobson, Joe Conner, Jim M. Wild, Claire Lewis

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Structural mechanism for signal transduction in RXR nuclear receptor heterodimers (2015)

Douglas J. Kojetin; Edna Matta-Camacho; Travis S. Hughes; Sathish Srinivasan; Jerome C. Nwachukwu; Valerie Cavett; Jason Nowak; Michael J. Chalmers; David P. Marciano; Theodore M. Kamenecka; Andrew I. Shulman; Mark Rance; Patrick R. Griffin; John B. Bruning; Kendall W. Nettles

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Some nuclear receptors dimerize with retinoid X receptor to allow ligand-dependent signalling. Here, Kojetin et al. use structural and biophysical techniques to identify structural changes that guide these complex signalling networks. Nature Communications doi: 10.1038/ncomms9013 Authors: Douglas J. Kojetin, Edna Matta-Camacho, Travis S. Hughes, Sathish Srinivasan, Jerome C. Nwachukwu, Valerie Cavett, Jason Nowak, Michael J. Chalmers, David P. Marciano, Theodore M. Kamenecka, Andrew I. Shulman, Mark Rance, Patrick R. Griffin, John B. Bruning, Kendall W. Nettles

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Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans (2015)

Sider Penkov; Damla Kaptan; Cihan Erkut; Mihail Sarov; Fanny Mende; Teymuras V. Kurzchalia

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article When facing environmental stress, the roundworm C. elegans forms so-called dauer larvae. Here, the authors show that dauer formation is influenced by cellular levels of the cofactor NADPH, which can be elevated by increasing biosynthesis of the disaccharide trehalose. Nature Communications doi: 10.1038/ncomms9060 Authors: Sider Penkov, Damla Kaptan, Cihan Erkut, Mihail Sarov, Fanny Mende, Teymuras V. Kurzchalia

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Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy (2015)

Kevin Moreau; Ghita Ghislat; Warren Hochfeld; Maurizio Renna; Eszter Zavodszky; Gautam Runwal; Claudia Puri; Shirley Lee; Farah Siddiqi; Fiona M. Menzies; Brinda Ravikumar; David C. Rubinsztein

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In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Starvation triggers autophagy by inhibiting mTOR signalling. Here, Moreau et al. identify an alternative, transcriptional activation pathway: starvation-induced JNK signalling upregulates Annexin A2 transcription, which in turn enhances actin-dependent transport of Atg9 vesicles from endosomes to autophagosomes. Nature Communications doi: 10.1038/ncomms9045 Authors: Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M. Menzies, Brinda Ravikumar, David C. Rubinsztein

Electronic ISSN: 2041-1723

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Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells (2015)

Kazuhito Naka; Yoshie Jomen; Kaori Ishihara; Junil Kim; Takahiro Ishimoto; Eun-Jin Bae; Robert P. Mohney; Steven M. Stirdivant; Hiroko Oshima; Masanobu Oshima; Dong-Wook Kim; Hiromitsu Nakauchi; Yoshihiro Takihara; Yukio Kato; Akira Ooshima; Seong-Jin Kim

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In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Chronic myelogenous leukaemia contains a stem cell fraction and targeting this population of cells is an attractive therapeutic strategy. Here, the authors demonstrate that the stem cells take up dipeptides and that inhibiting the dipeptide transporter could reduce the number of these stem cells in mice. Nature Communications doi: 10.1038/ncomms9039 Authors: Kazuhito Naka, Yoshie Jomen, Kaori Ishihara, Junil Kim, Takahiro Ishimoto, Eun-Jin Bae, Robert P. Mohney, Steven M. Stirdivant, Hiroko Oshima, Masanobu Oshima, Dong-Wook Kim, Hiromitsu Nakauchi, Yoshihiro Takihara, Yukio Kato, Akira Ooshima, Seong-Jin Kim

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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The precision of value-based choices depends causally on fronto-parietal phase coupling (2015)

Rafael Polanía; Marius Moisa; Alexander Opitz; Marcus Grueschow; Christian C. Ruff

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Recent studies suggest that value-based choices involve communication between parietal and prefrontal cortices. Here the authors use a novel, non-invasive cortical manipulation technique to demonstrate a causal role for such communication in mediating accurate value-based, but not perceptual, choices. Nature Communications doi: 10.1038/ncomms9090 Authors: Rafael Polanía, Marius Moisa, Alexander Opitz, Marcus Grueschow, Christian C. Ruff

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Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Sparsity-based Ankylography for Recovering 3D molecular structures from single-shot 2D scattered light intensity (2015)

Maor Mutzafi; Yoav Shechtman; Yonina C. Eldar; Oren Cohen; Mordechai Segev

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article X-ray laser holds promise for deciphering three-dimensional structures of organic molecules, which constitutes a major goal in structural biology. Mutzafi et al. propose an algorithm to overcome the issue of laser-induced sample damage based on prior knowledge of the atoms that comprise the molecules. Nature Communications doi: 10.1038/ncomms8950 Authors: Maor Mutzafi, Yoav Shechtman, Yonina C. Eldar, Oren Cohen, Mordechai Segev

Electronic ISSN: 2041-1723

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Seismic monitoring in the oceans by autonomous floats (2015)

Alexey Sukhovich; Sébastien Bonnieux; Yann Hello; Jean-Olivier Irisson; Frederik J. Simons; Guust Nolet

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Our understanding of the internal dynamics of the Earth is limited by the lack of seismic data available from oceanic domains. Here, the authors use observations from floating submarine seismographs to show that this technique may provide seismic data to fill the gaps in our knowledge. Nature Communications doi: 10.1038/ncomms9027 Authors: Alexey Sukhovich, Sébastien Bonnieux, Yann Hello, Jean-Olivier Irisson, Frederik J. Simons, Guust Nolet

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Low-threshold amplified spontaneous emission and lasing from colloidal nanocrystals of caesium lead halide perovskites (2015)

Sergii Yakunin; Loredana Protesescu; Franziska Krieg; Maryna I. Bodnarchuk; Georgian Nedelcu; Markus Humer; Gabriele De Luca; Manfred Fiebig; Wolfgang Heiss; Maksym V. Kovalenko

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-22

Description: Article Lead halide perovskite colloidal nanocrystals have promising optoelectronic properties, such as high photoluminescence quantum yields and narrow emission linewidths. Here, the authors report low-threshold amplified spontaneous emission and two kinds of lasing in nanostructured caesium lead halide perovskites. Nature Communications doi: 10.1038/ncomms9056 Authors: Sergii Yakunin, Loredana Protesescu, Franziska Krieg, Maryna I. Bodnarchuk, Georgian Nedelcu, Markus Humer, Gabriele De Luca, Manfred Fiebig, Wolfgang Heiss, Maksym V. Kovalenko

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Sperm navigation along helical paths in 3D chemoattractant landscapes (2015)

Jan F. Jikeli; Luis Alvarez; Benjamin M. Friedrich; Laurence G. Wilson; René Pascal; Remy Colin; Magdalena Pichlo; Andreas Rennhack; Christoph Brenker; U. Benjamin Kaupp

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-19

Description: Article Sperm use external cues to find the egg using ill-defined principles. Here the authors use holographic microscopy and optochemical tools to study sperm swimming in light-sculpted chemical 3D landscapes; they show that sperm translate the temporal stimulation pattern into multiple swimming behaviours to orient deterministically in a gradient. Nature Communications doi: 10.1038/ncomms8985 Authors: Jan F. Jikeli, Luis Alvarez, Benjamin M. Friedrich, Laurence G. Wilson, René Pascal, Remy Colin, Magdalena Pichlo, Andreas Rennhack, Christoph Brenker, U. Benjamin Kaupp

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Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection (2015)

Xing Pei Hao; Carissa M. Lucero; Baris Turkbey; Marcelino L. Bernardo; David R. Morcock; Claire Deleage; Charles M. Trubey; Jeremy Smedley; Nichole R. Klatt; Luis D. Giavedoni; Jan Kristoff; Amy Xu; Gregory Q. Del Prete; Brandon F. Keele; Srinivas S. Rao; W. Gregory Alvord; Peter L. Choyke; Jeffrey D. Lifson; Jason M. Brenchley; Cristian Apetrei; Ivona Pandrea; Jacob D. Estes

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-20

Description: Article HIV-1 infection in humans and SIV infection in rhesus macaques are associated with mucosal damage to the gastrointestinal tract, microbial translocation and chronic immune activation. Here the authors develop a non-human primate DSS colitis model that recapitulates these aspects of the disease in uninfected rhesus macaques. Nature Communications doi: 10.1038/ncomms9020 Authors: Xing Pei Hao, Carissa M. Lucero, Baris Turkbey, Marcelino L. Bernardo, David R. Morcock, Claire Deleage, Charles M. Trubey, Jeremy Smedley, Nichole R. Klatt, Luis D. Giavedoni, Jan Kristoff, Amy Xu, Gregory Q. Del Prete, Brandon F. Keele, Srinivas S. Rao, W. Gregory Alvord, Peter L. Choyke, Jeffrey D. Lifson, Jason M. Brenchley, Cristian Apetrei, Ivona Pandrea, Jacob D. Estes

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Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) (2015)

Matthias Altmeyer; Kai J. Neelsen; Federico Teloni; Irina Pozdnyakova; Stefania Pellegrino; Merete Grøfte; Maj-Britt Druedahl Rask; Werner Streicher; Stephanie Jungmichel; Michael Lund Nielsen; Jiri Lukas

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-21

Description: Article Intrinsically disordered proteins can phase separate from the soluble intracellular space. Here the authors show that the nucleic acid-mimicking biopolymer poly(ADP-ribose) (PAR) nucleates intracellular liquid demixing and orchestrates the earliest cellular responses to DNA breakage. Nature Communications doi: 10.1038/ncomms9088 Authors: Matthias Altmeyer, Kai J. Neelsen, Federico Teloni, Irina Pozdnyakova, Stefania Pellegrino, Merete Grøfte, Maj-Britt Druedahl Rask, Werner Streicher, Stephanie Jungmichel, Michael Lund Nielsen, Jiri Lukas

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Spontaneous emergence of chirality in achiral lyotropic chromonic liquid crystals confined to cylinders (2015)

Karthik Nayani; Rui Chang; Jinxin Fu; Perry W. Ellis; Alberto Fernandez-Nieves; Jung Ok Park; Mohan Srinivasarao

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-21

Description: Article Chirality in molecular materials is commonly used to manipulate the polarization of light. Here, Nayani et al . observe the formation of doubly twisted structure in achiral chromonic liquid crystals when confined to a cylindrical capillary, which leads to spontaneous chiral breaking. Nature Communications doi: 10.1038/ncomms9067 Authors: Karthik Nayani, Rui Chang, Jinxin Fu, Perry W. Ellis, Alberto Fernandez-Nieves, Jung Ok Park, Mohan Srinivasarao

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Rapid sequestration of rock avalanche deposits within glaciers (2015)

Stuart A. Dunning; Nicholas J. Rosser; Samuel T. McColl; Natalya V. Reznichenko

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-21

Description: Article Small, frequent rockfalls are thought to dominate the erosion of mountains above rockfalls, and little is known about rare large landslides as material is rapidly reworked. Here, the authors present sub-surface data from a large rock avalanche showing how such landslides can be recognized from their deposits. Nature Communications doi: 10.1038/ncomms8964 Authors: Stuart A. Dunning, Nicholas J. Rosser, Samuel T. McColl, Natalya V. Reznichenko

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Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli (2015)

Sang Woo Seo; Donghyuk Kim; Edward J. O’Brien; Richard Szubin; Bernhard O. Palsson

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article GadEWX regulons play a critical role in transcription regulation in response to acid stress. By reconstructing genome-wide GadEWX transcriptional network, here the authors show how GadEWX simultaneously coordinates many other cellular processes to produce the overall response of E. coli to acid stress. Nature Communications doi: 10.1038/ncomms8970 Authors: Sang Woo Seo, Donghyuk Kim, Edward J. O’Brien, Richard Szubin, Bernhard O. Palsson

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Genome-wide analysis of the genetic regulation of gene expression in human neutrophils (2015)

Anand Kumar Andiappan; Rossella Melchiotti; Tuang Yeow Poh; Michelle Nah; Kia Joo Puan; Elena Vigano; Doreen Haase; Nurhashikin Yusof; Boris San Luis; Josephine Lum; Dilip Kumar; Shihui Foo; Li Zhuang; Anusha Vasudev; Astrid Irwanto; Bernett Lee; Alessandra Nardin; Hong Liu; Furen Zhang; John Connolly; Jianjun Liu; Alessandra Mortellaro; De Yun Wang; Michael Poidinger; Anis Larbi; Francesca Zolezzi; Olaf Rotzschke

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article Neutrophils are abundant immune cells important for antimicrobial defence and in autoimmunity. Here, by mapping expression quantitative trait loci (eQTL) in neutrophils of Chinese ethnicity from Singapore, Andiappan et al. provide a resource for understanding immune-related trait associated genetic variants. Nature Communications doi: 10.1038/ncomms8971 Authors: Anand Kumar Andiappan, Rossella Melchiotti, Tuang Yeow Poh, Michelle Nah, Kia Joo Puan, Elena Vigano, Doreen Haase, Nurhashikin Yusof, Boris San Luis, Josephine Lum, Dilip Kumar, Shihui Foo, Li Zhuang, Anusha Vasudev, Astrid Irwanto, Bernett Lee, Alessandra Nardin, Hong Liu, Furen Zhang, John Connolly, Jianjun Liu, Alessandra Mortellaro, De Yun Wang, Michael Poidinger, Anis Larbi, Francesca Zolezzi, Olaf Rotzschke

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The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores (2015)

Ho-Soo Lee; Yong-Yea Park; Mi-Young Cho; Sunyoung Chae; Young-Suk Yoo; Myung-Hee Kwon; Chang-Woo Lee; Hyeseong Cho

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-12

Description: Article Polo-like kinase 1 (PLK1) is recruited to kinetochores during mitosis, where it is required for proper chromosome alignment. Lee et al . show that the chromatin-remodelling factor RSF1 is required for PLK1 recruitment, and that this function depends on phosphorylation of RSF1 by the mitotic kinase CDK1. Nature Communications doi: 10.1038/ncomms8904 Authors: Ho-Soo Lee, Yong-Yea Park, Mi-Young Cho, Sunyoung Chae, Young-Suk Yoo, Myung-Hee Kwon, Chang-Woo Lee, Hyeseong Cho

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Refining the pathway of carbide insertion into the nitrogenase M-cluster (2015)

Jared A. Wiig; Yilin Hu; Markus W. Ribbe

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article Carbide insertion plays a pivotal role in the biosynthesis of M-cluster, the cofactor of nitrogenase. Here the authors further define the pathway for interstitial carbide atom insertion, showing that the SAM-derived methyl group is transferred to a FeS precursor sulfur before hydrogen abstraction via an SN2-type reaction. Nature Communications doi: 10.1038/ncomms9034 Authors: Jared A. Wiig, Yilin Hu, Markus W. Ribbe

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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F (2015)

Gil Kanfer; Thibault Courthéoux; Martin Peterka; Sonja Meier; Martin Soste; Andre Melnik; Katarina Reis; Pontus Aspenström; Matthias Peter; Paola Picotti; Benoît Kornmann

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article During mitosis, mitochondria partition into daughter cells through microtubule-based transport. Here the authors show that the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F interact in a cell-cycle dependent manner to promote microtubule-directed movement of mitochondria. Nature Communications doi: 10.1038/ncomms9015 Authors: Gil Kanfer, Thibault Courthéoux, Martin Peterka, Sonja Meier, Martin Soste, Andre Melnik, Katarina Reis, Pontus Aspenström, Matthias Peter, Paola Picotti, Benoît Kornmann

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Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study (2015)

G. Paul Amminger; Miriam R. Schäfer; Monika Schlögelhofer; Claudia M. Klier; Patrick D. McGorry

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article Long-chain omega-3 polyunsaturated fatty acids are essential for neural development and lack of these fatty acids has been implicated in a number of mental health conditions. Here the authors report the longer-term efficacy of a randomized, double-blind, placebo-controlled clinical trial assessing the effects of fish oil capsules in individuals at ultrahigh risk for psychosis. Nature Communications doi: 10.1038/ncomms8934 Authors: G. Paul Amminger, Miriam R. Schäfer, Monika Schlögelhofer, Claudia M. Klier, Patrick D. McGorry

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Water impacting on superhydrophobic macrotextures (2015)

Anaïs Gauthier; Sean Symon; Christophe Clanet; David Quéré

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-13

Description: Article The behaviour of water impacting on surfaces is crucial to many applications, including anti-icings and self-cleaning. Here, Gauthier et al. show that the contact time of drops on a straight wire decreases with impact speed in a step manner due to the fragmentation of water in evenly divided subunits. Nature Communications doi: 10.1038/ncomms9001 Authors: Anaïs Gauthier, Sean Symon, Christophe Clanet, David Quéré

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Field propagation-induced directionality of carrier-envelope phase-controlled photoemission from nanospheres (2015)

F. Süßmann; L. Seiffert; S. Zherebtsov; V. Mondes; J. Stierle; M. Arbeiter; J. Plenge; P. Rupp; C. Peltz; A. Kessel; S. A. Trushin; B. Ahn; D. Kim; C. Graf; E. Rühl; M. F. Kling; T. Fennel

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-14

Description: Article The localized enhancement of laser light in optical near-fields of nanostructures enables the steering of ultrafast electronic motion. Here, the authors employ field propagation in nanospheres to obtain directional tunability and attosecond control of near-field-induced strong-field photoemission. Nature Communications doi: 10.1038/ncomms8944 Authors: F. Süßmann, L. Seiffert, S. Zherebtsov, V. Mondes, J. Stierle, M. Arbeiter, J. Plenge, P. Rupp, C. Peltz, A. Kessel, S. A. Trushin, B. Ahn, D. Kim, C. Graf, E. Rühl, M. F. Kling, T. Fennel

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Injectable cryogel-based whole-cell cancer vaccines (2015)

Sidi A. Bencherif; R. Warren Sands; Omar A. Ali; Weiwei A. Li; Sarah A. Lewin; Thomas M. Braschler; Ting-Yu Shih; Catia S. Verbeke; Deen Bhatta; Glenn Dranoff; David J. Mooney

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-14

Description: Article Immune responses are induced in the organized, cytokine-rich environment of lymph nodes, which can be mimicked by biomaterials. Here the authors show that injectable sponge-like gels decorated with immunostimulatory factors attract dendritic cells and boost antitumour immune responses in mice. Nature Communications doi: 10.1038/ncomms8556 Authors: Sidi A. Bencherif, R. Warren Sands, Omar A. Ali, Weiwei A. Li, Sarah A. Lewin, Thomas M. Braschler, Ting-Yu Shih, Catia S. Verbeke, Deen Bhatta, Glenn Dranoff, David J. Mooney

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Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax (2015)

Xiaodong Fang; Eviatar Nevo; Lijuan Han; Erez Y. Levanon; Jing Zhao; Aaron Avivi; Denis Larkin; Xuanting Jiang; Sergey Feranchuk; Yabing Zhu; Alla Fishman; Yue Feng; Noa Sher; Zhiqiang Xiong; Thomas Hankeln; Zhiyong Huang; Vera Gorbunova; Lu Zhang; Wei Zhao; Derek E. Wildman; Yingqi Xiong; Andrei Gudkov; Qiumei Zheng; Gideon Rechavi; Sanyang Liu; Lily Bazak; Jie Chen; Binyamin A. Knisbacher; Yao Lu; Imad Shams; Krzysztof Gajda; Marta FarréJaebum Kim; Harris A. Lewin; Jian Ma; Mark Band; Anne Bicker; Angela Kranz; Tobias Mattheus; Hanno Schmidt; Andrei Seluanov; Jorge Azpurua; Michael R. McGowen; Eshel Ben Jacob; Kexin Li; Shaoliang Peng; Xiaoqian Zhu; Xiangke Liao; Shuaicheng Li; Anders Krogh; Xin Zhou; Leonid Brodsky; Jun Wang

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-14

Description: Corrigendum Nature Communications doi: 10.1038/ncomms9051 Authors: Xiaodong Fang, Eviatar Nevo, Lijuan Han, Erez Y. Levanon, Jing Zhao, Aaron Avivi, Denis Larkin, Xuanting Jiang, Sergey Feranchuk, Yabing Zhu, Alla Fishman, Yue Feng, Noa Sher, Zhiqiang Xiong, Thomas Hankeln, Zhiyong Huang, Vera Gorbunova, Lu Zhang, Wei Zhao, Derek E. Wildman, Yingqi Xiong, Andrei Gudkov, Qiumei Zheng, Gideon Rechavi, Sanyang Liu, Lily Bazak, Jie Chen, Binyamin A. Knisbacher, Yao Lu, Imad Shams, Krzysztof Gajda, Marta Farré, Jaebum Kim, Harris A. Lewin, Jian Ma, Mark Band, Anne Bicker, Angela Kranz, Tobias Mattheus, Hanno Schmidt, Andrei Seluanov, Jorge Azpurua, Michael R. McGowen, Eshel Ben Jacob, Kexin Li, Shaoliang Peng, Xiaoqian Zhu, Xiangke Liao, Shuaicheng Li, Anders Krogh, Xin Zhou, Leonid Brodsky, Jun Wang

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Ionization-induced annealing of pre-existing defects in silicon carbide (2015)

Yanwen Zhang; Ritesh Sachan; Olli H. Pakarinen; Matthew F. Chisholm; Peng Liu; Haizhou Xue; William J. Weber

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-14

Description: Article Silicon carbide possesses myriad properties which render it an ideal material for implementation in harsh radiation environments. Here, the authors show that damaged SiC can be repaired through ionization-induced healing, which has broader implications for the design of future radiation-tolerant materials. Nature Communications doi: 10.1038/ncomms9049 Authors: Yanwen Zhang, Ritesh Sachan, Olli H. Pakarinen, Matthew F. Chisholm, Peng Liu, Haizhou Xue, William J. Weber

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p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia (2015)

Andrea Caporali; Marco Meloni; Audrey Nailor; Tijana MitićSaran Shantikumar; Federica Riu; Graciela B. Sala-Newby; Lorraine Rose; Marie Besnier; Rajesh Katare; Christine Voellenkle; Paul Verkade; Fabio Martelli; Paolo Madeddu; Costanza Emanueli

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-15

Description: Article Vascular function and repair is impaired in patients with diabetes. Here, Caporali et al. report that activation of the neurotrophin receptor in vascular endothelial cells induces the antiangiogenic miR-503, which impairs the function of neighbouring pericytes upon microparticle-mediated transfer. Nature Communications doi: 10.1038/ncomms9024 Authors: Andrea Caporali, Marco Meloni, Audrey Nailor, Tijana Mitić, Saran Shantikumar, Federica Riu, Graciela B. Sala-Newby, Lorraine Rose, Marie Besnier, Rajesh Katare, Christine Voellenkle, Paul Verkade, Fabio Martelli, Paolo Madeddu, Costanza Emanueli

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Boundaries for martensitic transition of 7Li under pressure (2015)

Anne Marie Schaeffer; Weizhao Cai; Ella Olejnik; Jamie J. Molaison; Stanislav Sinogeikin; Antonio M. dos Santos; Shanti Deemyad

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article Lithium metal under extreme pressures shows a sequence of structural phase transitions. Here, the authors use neutron scattering and X-ray diffraction techniques under high pressure to expand the experimental phase diagram of lithium, showing an unexpected deviation from existing boundaries. Nature Communications doi: 10.1038/ncomms9030 Authors: Anne Marie Schaeffer, Weizhao Cai, Ella Olejnik, Jamie J. Molaison, Stanislav Sinogeikin, Antonio M. dos Santos, Shanti Deemyad

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A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa (2015)

Xinzheng Guo; Shao-Bin Wang; Hongping Xu; Adema Ribic; Ethan J. Mohns; Yu Zhou; Xianjun Zhu; Thomas Biederer; Michael C. Crair; Bo Chen

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article Retinitis pigmentosa is an inherited form of blindness caused by the progressive loss of rod and cone photoreceptors. Here, Guo et al. show that expression of a short amino-terminal domain of the histone deacetylase HDAC4 prolongs cone survival in mouse models, helping to partially restore vision. Nature Communications doi: 10.1038/ncomms9005 Authors: Xinzheng Guo, Shao-Bin Wang, Hongping Xu, Adema Ribic, Ethan J. Mohns, Yu Zhou, Xianjun Zhu, Thomas Biederer, Michael C. Crair, Bo Chen

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells (2015)

Kyra Campbell; Jordi Casanova

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article Collective cell migration underlies the morphogenesis of many organs, and often involves heterogeneous cell types. Here the authors show a role for the adhesion molecule E-cadherin in maintaining the attachment of mesenchymal cells during Drosophila posterior midgut development. Nature Communications doi: 10.1038/ncomms8998 Authors: Kyra Campbell, Jordi Casanova

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance (2015)

Jiyong Liang; Zhi-Xiang Xu; Zhiyong Ding; Yiling Lu; Qinghua Yu; Kaitlin D. Werle; Ge Zhou; Yun-Yong Park; Guang Peng; Michael J. Gambello; Gordon B. Mills

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article AMP-activated protein kinase (AMPK) plays a role in starvation-induced autophagy, but a role in mitochondrial damage-induced mitophagy is not known. Here, Liang et al. show that AMPK is recruited to damaged mitochondria in an N -myristoylation-dependent manner and in turn recruits the ATG16 autophagy complex. Nature Communications doi: 10.1038/ncomms8926 Authors: Jiyong Liang, Zhi-Xiang Xu, Zhiyong Ding, Yiling Lu, Qinghua Yu, Kaitlin D. Werle, Ge Zhou, Yun-Yong Park, Guang Peng, Michael J. Gambello, Gordon B. Mills

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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The SnRK2-APC/CTE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways (2015)

Qibing Lin; Fuqing Wu; Peike Sheng; Zhe Zhang; Xin Zhang; Xiuping Guo; Jiulin Wang; Zhijun Cheng; Jie Wang; Haiyang Wang; Jianmin Wan

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-16

Description: Article The hormones abscisic acid and gibberellins act antagonistically in plant development and stress responses. Here Lin et al . show that the rice Tiller Enhancer protein is required for gibberellin-induced degradation of abscisic acid signalling components, uncovering mechanistic insights into hormone signalling crosstalk. Nature Communications doi: 10.1038/ncomms8981 Authors: Qibing Lin, Fuqing Wu, Peike Sheng, Zhe Zhang, Xin Zhang, Xiuping Guo, Jiulin Wang, Zhijun Cheng, Jie Wang, Haiyang Wang, Jianmin Wan

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Superconductivity-induced re-entrance of the orthorhombic distortion in Ba1−xKxFe2As2 (2015)

A. E. Böhmer; F. Hardy; L. Wang; T. Wolf; P. Schweiss; C. Meingast

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-02

Description: Article The interplay between magnetic and superconducting phases is important to understand the physics of iron-based superconductivity. Here, the authors use thermodynamic measurements on Ba 1−x K x Fe 2 As 2 single crystals to provide details of its phase diagram and the re-entrance of a C 2 spin-density-wave phase. Nature Communications doi: 10.1038/ncomms8911 Authors: A. E. Böhmer, F. Hardy, L. Wang, T. Wolf, P. Schweiss, C. Meingast

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Hydrologically driven ecosystem processes determine the distribution and persistence of ecosystem-specialist predators under climate change (2015)

Matthew J. Carroll; Andreas Heinemeyer; James W. Pearce-Higgins; Peter Dennis; Chris West; Joseph Holden; Zoe E. Wallage; Chris D. Thomas

Springer Nature

In: Nature Communications

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Publication Date: 2015-08-02

Description: Article Climatic change is predicted to impact moisture-dependent ecosystems. Here Carroll et al . show that a combination of physical, biophysical and ecosystem processes determine the abundance and distribution of three bird species that feed on craneflies in blanket bogs. Nature Communications doi: 10.1038/ncomms8851 Authors: Matthew J. Carroll, Andreas Heinemeyer, James W. Pearce-Higgins, Peter Dennis, Chris West, Joseph Holden, Zoe E. Wallage, Chris D. Thomas

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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