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  • bic Book Industry Communication::M Medicine  (628)
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  • English  (916)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
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  • 2
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mg alloy is the lightest metallic structural material and possesses the advantages of high specific strength, high specific stiffness, good electromagnetism shield, good damping capacity, good machinability, and easy recycling, etc. Therefore, it has extremely broad application prospects and has drawn considerable interest in the fields of automobile, electronics, electrical appliances, transportation, aerospace, and aviation. In addition, Mg alloys are gradually showing application potential in emerging industries, serving as biodegradable metals in the biomedical field, functional material for hydrogen storage, and so on. This Special Issue (SI), entitled “Research Progress in High-Performance Magnesium Alloy and Its Applications”, presents recent developments and excellent results in the field of Mg alloys, and includes 10 articles and one editorial covering some interesting aspects of the topic.
    Keywords: grain refinement ; high strength and toughness ; {10–12} twin ; Mg-Gd-Y alloy ; multidirectional impact forging ; Mg-Zn-Mn-Ca ; Ca2Mg6Zn3 phase ; corrosion behaviors ; SKPFM ; boride ; MgB2 ; mechanical alloying ; ignition ; combustion ; flame temperature ; magnesium alloy ; biocompatibility ; surface coating modification ; corrosion resistance ; implantable bio-metal materials ; filler material ; welding ; scandium ; microstructure modification ; mechanical properties ; microstructure ; texture ; stretch formability ; high temperature cross-rolling ; annealing ; wire arc additive manufacturing ; cold metal transfer ; Al-Mg alloys ; orthogonal experiment ; Mg-Bi-Ca alloy ; hot deformation ; constitutive model ; dynamic recrystallization kinetics ; Mg alloy ; twinning ; random orientation ; compression ; room temperature ; backward extrusion ; tensile strength ; failure mechanism ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: This reprint focuses on both advanced metals and their alloys and the areas of physical and process metallurgy, materials science, and processing techniques. Specific areas of interest also include titanium/nickel-based superalloys, intermetallics, advanced metallic materials, nanomaterials, metal matrix composites, functional materials, related synthesis and processing techniques, finite element modelling, statistical analysis, physical/mechanical property characterization, experimental validation, and other relevant phenomena. Physical metallurgy is important in the design and optimization of advanced materials with superior physical and mechanical properties through microstructural modifications and processing techniques. The goal of reprint was to bring together recent progress, novel technologies, and advanced equipment for the design and development of advanced metals and alloys and provide guidelines/benchmarks for further research in related areas. Composites, intermetallics, and nanomaterials as well as functional materials will be also included. Some of the recent advances in the field of advanced metals and alloys include novel material processing techniques, manufacturing methods and theories, microstructural characterization, modelling development, and advanced equipment. Conventional and nonconventional processes related to machining, forming, laser processing, additive/subtractive manufacturing, surface modification, and the solidification of high-performance alloys/metals are also included.
    Keywords: Fe-rich Al–Si alloy ; β-Al5FeSi phase ; cooling rate ; melt spinning ; microstructure ; strengthening mechanisms ; Zn-Mg-Ti alloy ; biodegradable metals ; mechanical properties ; cytotoxicity ; Fe-B-W alloy ; manganese ; aluminum ; molten zinc ; microanalysis ; corrosion ; hydrogenated–dehydrogenated titanium powder ; laser directed energy deposition ; mechanical property ; radio frequency plasma technique ; high entropy alloy ; bulk metallic glass ; similar element substitution/addition ; glass forming ability ; lattice distortion ; sapphire ; surface metallization ; deposition mechanism ; wettability ; low-temperature joining ; silver alloy bonding wire ; bonding strength ; vulcanization resistance ; cathodic passivation ; Mg–Nd alloy ; precipitate ; eutectic growth ; modelling and simulation ; recrystallization ; microstructure-property characterization simulation and modeling ; heat treatment and surface treatment ; TC4 alloy ; EBCHM ; aging treatment ; glass-forming ability ; corrosion behavior ; amorphous alloy ; phase transformation ; mechanical behavior ; corrosion wear resistance ; gear grinding ; white layer ; grinding temperature ; surface integrity ; AlSi10Mg alloy ; friction stir processing ; grain boundary ; texture ; dynamic recrystallization ; silver wire ; wire bonding ; chloride ions ; ion migration ; galvanic corrosion ; Cu-15Ni-8Sn alloys ; grain size ; solution treatment ; microalloying ; microstructural evolution ; laser-powder bed fusion ; MgAl2O4 ; TiB2 ; metallothermic reduction ; SHS powder metallurgy ; combustion wave propagation ; HSLA steel ; microstructural characterization ; laser welding ; thick plate ; corrosion resistance ; high entropy alloys ; lightweight ; magnesium alloys ; ultrasound treatment ; solution ; aging ; Mg17Al12 ; converter ; vortex ; flow field analysis ; numerical simulation ; steel ball ; skew rolling ; cold forming ; stainless steel ; copper–scandium CuSc ; copper alloy ; differential scanning calorimetry DSC ; precipitation kinetics ; cold-working ; cold-rolling ; activation energy ; Kissinger method ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This Special Issue covers manufacturing of a smart polymer composites via choice of ingredients, such as polymer, filler, and additives, as well as their unique composition. It also covers the smart processing of polymer composites, which is influenced by the choice of mixers, processing condition, processing technique, etc.
    Keywords: thermoplastic polyurethane ; expanded bead ; supercritical CO2 foaming ; expansion ratio ; resilience ; hardness ; poly(lactic acid) ; lignin ; maleic anhydride ; chemical modification ; 3D printing filament ; SEBS ; membrane ; water uptake ; impedance spectroscopy ; ionic conductivity ; phlogopite ; natural rubber (NR) ; ethylene-propylene-diene monomer rubber (EPDM) ; mechanical properties ; compatibility ; nylon 6 ; polyketone ; chain extender ; hydrogen bonding ; chain branching ; chain crosslinking ; melt viscosity ; shape memory polymer ; NIR light responsive ; semicrystalline maleated polyolefin elastomer ; polyaniline ; melt blending ; adhesive ; fluorosilicone ; thermal conductivity ; magnesium oxide ; boron nitride ; syntactic foams ; hyperbranched polymer ; polyamide 6 ; hollow glass microsphere ; lubricant ; compatibilizer ; composites ; silica ; silane ; hydrolysis ; interfacial adhesion ; zinc mechanism ; hybrid flame retardant materials ; influence of gypsum ; minimum total heat release ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: Third millennium engineering address new challenges in materials sciences and engineering. In particular, the advances in materials engineering combined with the advances in data acquisition, processing and mining as well as artificial intelligence allow for new ways of thinking in designing new materials and products. Additionally, this gives rise to new paradigms in bridging raw material data and processing to the induced properties and performance. This present topical issue is a compilation of contributions on novel ideas and concepts, addressing several key challenges using data and artificial intelligence, such as:- proposing new techniques for data generation and data mining;- proposing new techniques for visualizing, classifying, modeling, extracting knowledge, explaining and certifying data and data-driven models;- processing data to create data-driven models from scratch when other models are absent, too complex or too poor for making valuable predictions;- processing data to enhance existing physic-based models to improve the quality of the prediction capabilities and, at the same time, to enable data to be smarter; and- processing data to create data-driven enrichment of existing models when physics-based models exhibit limits within a hybrid paradigm.
    Keywords: plasticity ; machine learning ; constitutive modeling ; manifold learning ; topological data analysis ; GENERIC ; soft living tissues ; hyperelasticity ; computational modeling ; data-driven mechanics ; TDA ; Code2Vect ; nonlinear regression ; effective properties ; microstructures ; model calibration ; sensitivity analysis ; elasto-visco-plasticity ; Gaussian process ; high-throughput experimentation ; additive manufacturing ; Ti–Mn alloys ; spherical indentation ; statistical analysis ; Gaussian process regression ; nanoporous metals ; open-pore foams ; FE-beam model ; data mining ; mechanical properties ; hardness ; principal component analysis ; structure–property relationship ; microcompression ; nanoindentation ; analytical model ; finite element model ; artificial neural networks ; model correction ; feature engineering ; physics based ; data driven ; laser shock peening ; residual stresses ; data-driven ; multiscale ; nonlinear ; stochastics ; neural networks ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Additive manufacturing (AM) processes are gaining more and more attention from many industrial fields, mainly because they are revolutionizing the components’ designs and production lines. The complete industrialization of these processes has to be supported by the full understanding of correlation between AM building conditions and the final materials’ properties. Another critical aspect is that nowadays only a reduced number of materials processable by AM are available on the market. It is, therefore, fundamental to widen the materials’ portfolio, and to study and develop new materials that can take advantage of these unique building processes.
    Keywords: amorphous poly(lactide acid) ; poly(styrene-co-methyl methacrylate) ; polymer blends ; filament extrusion ; 3D printing ; additive manufacturing ; silicon nitride ; high performance ceramics ; photopolymerisation ; lithography-based ceramic manufacturing ; fused-deposition modeling ; mechanical properties ; thermal behavior ; polyetherimide ; fused filament modelling ; design of experiments ; directed energy deposition ; AISI 316L ; microstructure ; LPBF ; as-built ; as-cast ; microhardness ; tensile test ; Ni–Cu alloy ; materials development ; polymers ; metals ; ceramics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This book, consisting of 21 articles, including three review papers, written by research groups of experts in the field, considers recent research on reinforced polymer composites. Most of them relate to the fiber-reinforced polymer composites, which are a real hot topic in the field. Depending on the reinforcing fiber nature, such composites are divided into synthetic and natural fiber-reinforced ones. Synthetic fibers, such as carbon, glass, or basalt, provide more stiffness, while natural fibers, such as jute, flax, bamboo, kenaf, and others, are inexpensive and biodegradable, making them environmentally friendly. To acquire the benefits of design flexibility and recycling possibilities, natural reinforcers can be hybridized with small amounts of synthetic fibers to make them more desirable for technical applications. Elaborated composites have great potential as structural materials in automotive, marine and aerospace application, as fire resistant concrete, in bridge systems, as mechanical gear pair, as biomedical materials for dentistry and orthopedic application and tissue engineering, as well as functional materials such as proton-exchange membranes, biodegradable superabsorbent resins and polymer electrolytes.
    Keywords: glass fibers ; surface modification ; polyethersulfone ; impregnation ; composite materials ; mechanical properties ; damping properties ; stability ; 3D printing ; composites ; DLP ; lignocellulose ; nanoindentation ; fiber-reinforced polymer ; natural fibers ; synthetic fibers ; PET fiber ; PP ; compatibility ; modification ; co-injection molding ; fiber reinforced plastics (FRP) ; fiber orientation distribution (FOD) ; micro-computerized tomography (μ-CT) scan technology ; bearing ; salt fog aging ; glass-flax hybrid coposites ; pinned joints ; failure modes ; polymer-matrix composites ; carbon fibers ; polysulfone ; rubber ; short jute fibers ; surface treatments ; scanning electron microscopy ; PVA ; CMC ; Na2CO3 ; film ; hydrogel mechanical properties ; nanocomposites ; double-network hydrogels ; polymer–nanoparticle interactions ; bamboo-plastic composites (BPCs) ; waste bamboo fibers ; chemical composition ; physico-mechanical properties ; thermal decomposition kinetics ; PEEK composites ; reinforcements ; self-lubricating bush ; friction and wear ; pin joints ; flat slab ; two-way shear ; carbon fiber reinforced polymers ; glass fiber reinforced polymers ; natural rubber ; maleated natural rubber ; palm stearin ; halloysite nanotubes ; heat treatment ; surface modification of staple carbon fiber ; natural rubber latex ; reinforcement mechanism ; dopamine ; rubber composite ; bifunctionally composite ; sulfonic acid based proton exchange membrane ; silica nanofiber ; mechanical stability ; high temperature fuel cell ; polyetherimide ; polycarbonate ; polyphenylene sulfone ; kenaf fibre ; glass fibre ; hybrid composites ; low velocity impact ; damage progression ; bamboo ; n/a ; poly (lactic acid) (PLA) ; wastes rubber ; recycling ; tensile properties ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the implementation of sustainable concrete systems has been a topic of great interest in the field of construction engineering worldwide, as a result of the large and rapid increase in carbon emissions and environmental problems resulting from traditional concrete production and industry. For example, the uses of supplementary cementitious materials, geopolymer binder, recycled aggregate and industrial/agricultural wastes in concrete are all approaches to building a sustainable concrete system. However, such materials have inherent flaws due to their variety of sources, and exhibit very different properties compared with traditional concrete. Therefore, they require specific modifications in preprocessing, design, and evaluation before use in concrete. This reprint, entitled “Advances in Sustainable Concrete System”, covers a broad range of advanced concrete research in environmentally friendly concretes, cost-effective admixtures, and waste recycling, specifically including the design methods, mechanical properties, durability, microstructure, various models, hydration mechanisms, and practical applications of solid wastes in concrete systems.
    Keywords: high-strength concrete ; energy evolution ; elastic strain energy ; brittleness evaluation index ; concrete ; humidity ; moisture absorption ; moisture desorption ; numerical simulation ; acoustic emission ; AE rate process theory ; corrosion rate ; damage evolution ; axial load ; precast concrete structure ; lattice girder semi-precast slabs ; bending resistance ; FE modelling ; concrete damage ; GSP ; high strength ; hydration ; strength ; penetrability ; rice husk ash ; sustainable concrete ; artificial neural networks ; multiple linear regression ; eco-friendly concrete ; green concrete ; sustainable development ; artificial intelligence ; data science ; machine learning ; bagasse ash ; mechanical properties ; natural coarse aggregate ; recycled coarse aggregate ; two-stage concrete ; materials design ; recycled concrete ; crumb rubber concrete ; crumb rubber ; NaOH treatment ; lime treatment ; water treatment ; detergent treatment ; compressive strength ; materials ; adhesively-bonded joint ; temperature aging ; residual strength ; mechanical behavior ; failure criterion ; steel slag powder ; compound activator ; mortar strength ; orthogonal experiment ; GM (0, N) model ; ultrafine metakaolin ; silica fume ; durability ; fiber-reinforced concrete ; damage mechanism ; uniaxial tension ; cracked concrete ; crack width ; crack depth ; tortuosity ; sustainability ; concrete composites ; sulfate and acid attacks ; WPFT fibers ; coal gangue ; gradation ; cement content ; unconfined compressive strength ; freeze–thaw cycle ; minimum energy dissipation principle ; three-shear energy yield criterion ; damage variable ; constitutive model ; phosphorus slag ; limestone ; sulphate-corrosion resistance ; volume deformation ; blast furnace ferronickel slag ; alkali-activated material ; dosage of activator ; reactive powder concrete ; beam-column joint ; FE modeling ; crack ; cementitious gravel ; fly ash ; age ; optimal dosage ; bamboo ; sawdust ; pretreatment ; bio-based material ; mechanical property ; self-compacting concrete ; supplementary cementitious materials ; hydration mechanisms ; microstructure ; fresh properties ; synthetic polymer ; high temperature ; bentonite-free drilling fluid ; rheology ; filtration ; FRP reinforced concrete slab ; punching shear strength ; SHAP ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Metal 3D printing, as an advanced forming, can manufacture parts directly from digital model by using layer by layer material build-up approach. This manufacturing method can prepare complex shape metal parts in short time, with and high precision. Three-dimensional printing processes can be classified into two major groups: Powder Bed Fusion-based technologies and Directed Energy Deposition. Three-dimensional printing features freedom of part complexity, part design, and light-weighting for aerospace, automobile, and other industries application. The Global Metal 3D Printing Market is mainly driven by the the fast developing of aerospace and automobile industry. The Global Metal 3D Printing Market size was valued at USD 534.18 Million in 2020 and is projected to reach USD 4458.76 Million by 2028, growing at a CAGR of 30.38% from 2021 to 2028.
    Keywords: 17-4PH ; SLM ; solution temperature ; microstructure and properties ; selective laser melting ; CuCrZr alloy ; process parameters ; relative density ; tensile properties ; Ni-based superalloys ; electron beam melting ; additive manufacturing ; Argon gas atomized ; plasma rotation electrode process ; powder characteristics ; residual stresses ; selective laser melting (SLM) ; finite element modeling (FEM) ; triply periodic minimal surface (TPMS) ; copper corrosion ; liquefied petroleum gas ; H2S corrosion ; SEM ; XPS ; CLF-1 steel ; microstructure ; mechanical properties ; in-situ alloying ; composition inhomogeneity ; computer simulation ; processing map ; laser powder bed fusion ; graphene ; high temperature ; mechanical property ; alumina ; cobalt-chromium-molybdenum alloy ; electroless plating ; friction performance ; implants ; Laser Powder Bed Fusion ; defects ; process parameter ; powder bed fusion ; surface roughness ; porosity ; residual stress ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Absorbable metals have shown significant clinical potential for temporary implant applications, where the material is eventually replaced by healthy, functioning tissue. However, several challenges remain before these metals can be used in humans. Innovations and further improvements are required. This book collects scientific contributions dealing with the development of absorbable metals with improved and unique corrosion and mechanical properties for applications in highly loaded implants or cardiovascular and urethral stents.
    Keywords: surface treatments ; roughness ; Mg-alloys ; degradation behavior ; absorbable ; corrosion ; degradation ; magnesium ; ureteral stent ; zinc ; mandibular condylar fracture ; unsintered hydroxyapatite/poly-l-lactide composite plate ; bioactive resorbable plate ; biomechanical loading evaluation ; fracture fixation ; WE43/HA composite ; friction stir processing ; microstructure ; mechanical properties ; corrosion behavior ; absorbable metal ; cytotoxicity ; stent ; ureteral ; urothelial cells ; zinc alloy ; poly-L-lactide ; uncalcined and unsintered hydroxyapatite ; biocompatibility ; osteoconductivity ; mesenchymal stem cell ; iron foam ; polyethyleneimine (PEI) ; biodegradation ; powder metallurgy ; coating ; biodegradable magnesium implants ; bioceramics ; bioactivity ; orthopedic implant ; bone surgery ; absorbable implants ; magnesium (Mg) ; oral and maxillofacial ; orthopedic ; titanium (Ti) ; biomaterials ; electrochemistry ; hydrogen evolution ; microscopy ; Mg-Zn-Sn alloy ; osteoinductive activity ; sirolimus ; rabbit coronary artery endothelial cells ; smooth muscle cells ; bioabsorbable metals ; in-vivo biocompatibility ; strontium ; toxicity ; systemic reactions ; alloy accumulation ; internal organs ; iron ; corrosion rate ; biodegradable material ; n/a
    Language: English
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: The articles featured in this Special Issue cover different aspects of the design, testing, and application of various types of supplementary cementitious materials in concrete. The results of the research, conducted by over 50 international universities and scientific centers, prove the great interest in the SCM topic.
    Keywords: crystalline admixture ; chemical exposure ; sulphuric acid attack ; durability ; Xypex ; fly ash ; substitution strategy ; structural concrete ; steel reinforcement ; limit states ; RC beams in bending ; carbon footprint ; concrete ; carbonation modeling ; calcareous fly ash ; biomass ; wood ash ; fibrocement ; strength ; mortar ; clean coal combustion ; fluidized bed fly ash ; microstructure ; phase composition ; portlandite ; unburned carbon ; slag ; soil stabilization ; embankment ; cement ; lime ; high temperature ; damage ; permeability ; CEMI and CEMIII ; mechanical properties ; alkali-activated concrete ; geopolymer concrete ; flexure ; beams ; fiber-reinforced concrete ; crack spacing ; tension stiffening ; bamboo ash ; supplementary materials ; elevated temperature ; high volume fly ash (HVFA) ; steel reinforcing fiber ; jacketing ; environmental impact ; fibre reinforced ; alkali-activated ; strain hardening ; recycled cementitious supplementary material ; comprehensive concrete recycling ; recycled fine fraction ; rehydration reactivity ; compressive strength ; ground granulated blast furnace slag ; apparent activation energy ; equivalent age ; construction debris ; recycling ; circular economy ; eco-friendly concretes ; fly ash (FA) ; silica fume (SF) ; palm oil fuel ash (POFA) ; rice husk ash (RHA) ; sewage sludge ash (SSA) and sugarcane bagasse ash (SBA) ; mine tailings ; marble dust ; construction and demolition debris (CDD) ; porous feldspar ; activation ; substitute material ; energy saving concrete ; calcined clay ; binder ; supplementary cementitious materials ; cement-based materials ; steatite ; wood particles ; Portland cement ; fire performance ; tensile strength ; micro-silica/silica fume ; steel fiber ; high performance concrete (HPC) ; self-consolidating concrete (SCC) ; flowability ; freeze-thaw cycle ; fire resistance ; bentonite ; clays ; cryogenic condition ; GGBS ; thermal conductivity ; semi-adiabatic test ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 27
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book derives from the Special Issue of the Manufacturing Engineering Society 2019 (SIMES-2019) that has been launched as a joint issue of the journals Materials and Applied Sciences. The 29 contributions published in this Special Issue of Materials present cutting-edge advances in the field of manufacturing engineering focusing on additive manufacturing and 3D printing; advances and innovations in manufacturing processes; sustainable and green manufacturing; manufacturing of new materials; metrology and quality in manufacturing; industry 4.0; design, modeling, and simulation in manufacturing engineering; and manufacturing engineering and society. Among them, the topic "Additive Manufacturing and 3D Printing" has attracted a large number of contributions in this journal due to its widespread popularity and potential.
    Keywords: Bayesian inference ; control chart ; dynamic methodology ; hidden Markov chain ; occupational accident ; risk assessment ; risk control ; risk management ; Fused Deposition Modeling ; roughness ; Polylactic Acid ; print orientation angle ; build angle ; titanium alloys ; sustainable lubrication ; cryogenic lubrication ; MQL ; OD grinding ; CBN ; dressing ; rotary dresser ; wear ; CVD diamond ; additive manufacturing ; 3D printing ; fused filament fabrication ; flexural properties ; fatigue ; PLA ; cements ; ballast waste ; cornubianite ; mechanical properties ; Spain ; joining ; forming ; sheet–tube connections ; experimentation ; modelling and simulation ; quality enhancement ; process parameters ; design optimization ; calibration artifact ; kinematic support ; dimensional metrology ; machine tool ; length measurement ; rapid prototyping ; efficiency ; printing time ; experimental model ; prepeg ; carbon fiber ; Raman spectroscopy ; AWJM ; waterjet ; CFRP ; kerf taper ; surface quality ; metal forming ; bi-metallic ; cylinders ; compression ; finite elements ; microscopy ; cold expansion ; mandrel ; cold-forming ; swaging ; shipbuilding ; LARG paradigm ; supply chain ; coordinate metrology ; confocal microscopy ; measurement ; calibration ; traceability ; uncertainty ; quality assessment ; digital image correlation ; indentation process ; incremental forming ; finite element method ; material flow ; AWJM (Abrasive waterjet machining) ; CFRTP (Carbon fiber-reinforced thermoplastics) ; RSM (response surface methodology) ; ANOVA (Analysis of variance) ; C/TPU (carbon/polyurethane) ; image processing ; position control ; accuracy ; micromachines ; position compensation ; inverse conical perspective ; micromanufacturing ; manufacturing systems ; mechatronics ; FDM ; bimodulus materials ; standards ; finite element analysis (FEA) ; ABS ; anisotropy ; infill density ; layer orientation ; ASTM D638–14:2014 ; ISO 527–2:2012 ; grounding electrodes in two-layered soils ; step and touch potentials ; step potentials upper bound ; orthoses ; prostheses ; fused deposition modeling ; laminated object manufacturing ; selective laser sintering ; laser tracker ; Monte Carlo method ; verification ; green manufacturing ; sustainability metrics ; cleaner product life cycle ; material removal processes ; hybrid components ; light alloys ; magnesium ; aluminum ; drilling ; dry machining ; cold compressed air ; lubrication and cooling systems ; arithmetical mean roughness ; Ra ; average maximum height ; Rz ; repair and maintenance operations ; fused deposition modelling ; composites ; polymer injection moulding ; polyamide ; metal matrix composite ; Al-SiC ; microstructure ; machining ; cooling compressed air ; thrust force ; energy ; material removed rate ; PEEK-GF30 ; multi-response optimization ; sustainable manufacturing ; metrology ; industry 4.0 ; modeling and simulation ; quality in manufacturing ; technological and industrial heritage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: In this book, the performance of homogeneous and heterogeneous catalysts applied in biomass processing was assessed, paying special attention to the main advantages and challenges related to their use. Indeed, these challenges are opportunities to develop new research lines that could be fruitful in the near future. Thus, different studies are included, dealing with diverse subjects, with one main goal in common: the improvement of different aspects related to biomass processing through the use of catalysts.
    Keywords: nanospheroids ; zinc-doped CaO ; natural triglycerides ; aminolysis ; heterogeneous catalyst ; recyclability ; catalyst ; sodium hydroxide ; fatty acid methyl ester ; central composite rotatable design ; operational conditions ; aerated irrigation ; soil enzyme activity ; soil microbial biomass ; soil respiration ; bio-derived phenol ; Ni-Cu-Co/Al2O3 ; in-situ hydrodeoxygenation ; cyclohexane ; hydrogenolysis ; biomass ; 5-hydroxymethylfurfural ; 2,5-furandicrboxylic acid ; aerobic oxidation ; metal catalysts ; acid catalysis ; biodiesel ; biofuel ; esterification ; fatty acid ; methanolysis ; molybdenum oxide ; transesterification ; vegetable oil ; fatty acid methyl esters ; 2-ethyl-1-hexanol ; 1-heptanol ; 4-methyl-2-pentanol ; viscosity ; flash and combustion points ; methyl oleate ; methyl ricinoleate ; cellulase ; cellulose ; paper sludge ; Saccharomyces cerevisiae ; synergism ; furfural ; carbon-supported catalyst ; xylose conversion ; iron ; heterogeneous catalysts ; thermoset polymer ; epoxy ; cellulose nanofiber ; curing characteristics ; thermal properties ; mechanical properties ; RSM ; numerical optimization ; keratinase ; feather ; Bacillus sp. ; amino acids ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: In recent years, there has been significant progress in biomass research as bio-based products are beneficial to the environment, energy-saving, and cost-saving if they are processed properly. The book collects the most state-of-the-art works related to the natural fiber composites in a Special Issue entitled “Natural Fiber Biocomposites”. These works address all the issues related the manufacturing of natural fiber composite products, from (1) raw materials, such as wood, flax fiber, and cellulose nanofiber; to the (2) raw material treatments, such as furfuryl alcohol pretreatment, ultrasonic vibration treatment (UVT), and extraction method for the resins; to the (3) process of the composites fabrication, such as thermo-hygro-mechanical densification; and to the (4) performance of the composites, including mechanical, moisture absorption, opacity, thermal, and biodegradability. Discussions on the adhesives/resins used in the natural fiber composites fabrication, such as dried distiller’s grains and solubles (DDGS), pennycress (Thlaspi arvense L.) press cakes (PPC), and lesquerella [Lesquerella fendleri (A. Gary) S. Watson] press cake (LPC), starch, and polylactic acid (PLA), are also part of the book. It is believed the technical information presented in this book will contribute to the development of the bio-based composites.
    Keywords: flexural properties ; panels ; by-products ; non-dietetic uses ; modulus of rupture ; modulus of elasticity ; nanofiber cellulose ; water hyacinth ; thermoplastic starch ; bionanocomposites ; ultrasonic vibration time ; density ; gas permeability ; thermal conductivity ; densification ; durability ; green composites ; cellulosic fibers ; water uptake ; biocomposite ; starch ; cellulose ; ultrasonication ; moisture absorption ; opacity ; mat porosity ; mat thermal conductivity ; fiber size ; hot-pressing process ; PLA ; flax ; thermoplastic composites ; mechanical properties ; biodegradability ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-24
    Description: This book consists of 12 original research articles and one comprehensive review from invited chemists from around the world covering different fields of chemistry. The article on analytical chemistry features the analysis of highly polar metabolites in biological fluids, the determination of non-steroidal anti-inflammatory drugs with a gas chromatography coupled to ion trap mass spectrometry, and the synthesis of MoS2 nanostructures for the production of near-infrared photodetectors. The environmental chemistry articles include discussions on weekly and longitudinal elemental variability in hair samples, use of bottom ash as a stabilizing agent, the removal of phosphorus from the effluent of a paper company, and the chemistry and consequences of arsenic contamination of groundwater. Polymer/coating chemistry coverage includes the incorporation of superabsorbent polymers into cementitious-based composite materials, the use of licorice root extracts for edible coatings and postharvest quality improvement, and the use of mucin-grafted polyethylene glycol-based micro- for the oral delivery of insulin. The reported research on nanomaterials chemistry covers the synthesis of ZnO-doped ceria nanorods made up of CeO2/ZnO mixed oxides, and the production of carbon fiber-reinforced plastic bonded joints with novel carbon nanotube (CNT) adhesive films. A final paper on flavonol chemistry utilizes LC-MS/MS to investigate the stability of four common types of dietary flavonols.
    Keywords: carbon nanotubes ; aging ; structural health monitoring ; water uptake ; adhesive film ; surfactant ; insulin ; mucin ; polyethylene glycol ; microparticles ; toxicology ; biomass production ; Chlorella vulgaris ; microalgae ; nutrients removal ; paper industry effluent ; effluent treatment ; non-steroidal anti-inflammatory drug (NSAID) ; urine ; doping analysis ; dispersive liquid–liquid microextraction (DLLME) ; gas chromatography mass spectrometry (GC-MS) ; sewage sludge disposal ; municipal solid waste ; co-combustion ; fly ash ; bottom ash ; heavy metal stabilization ; polar amino acids ; mixed cationic-RP column ; LC-HRMS ; BMAA ; TMAO ; flavonols ; H2O2 ; saliva ; metabolism ; oxidation ; LC-MS/MS ; CeO2/ZnO mixed oxides ; zinc oxide ; ceria nanorods ; oxygen storage capacity ; CO oxidation ; licorice ; chitosan ; edible coating ; strawberry shelf life ; rheological properties ; ultrasound-assisted extraction ; mechanical properties ; microstructure ; self-healing ; SAP ; microCT ; cementitious materials ; mortar ; hairs ; variability ; week ; longitudinal ; element ; metals ; INAA ; occupational exposure ; unexposed subject ; MoS2 ; microwave-assisted hydrothermal synthesis ; low-cost photosensors ; arsenic ; groundwater ; contamination ; water quality ; domestic filter systems ; health effects ; treatment methods ; Bangladesh ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Additive manufacturing (AM) has been at the center of attention of studies and industry. The AM process involves gradual build-up in layers, and capability in the fabrication of complex shapes with low cost. Advances in the processing of polymers and polymer composites with this method are in the domain of this journal, which can provide a vital resource for anyone involved in additive manufacturing. This Special Issue cover original reviews and research articles dedicated to: AM processes of manufacturing and materials; Process–microstructure/morphology–properties relationships; Optimization of process parameters; Mechanical properties of fabricated parts; Modeling and simulation.
    Keywords: hybrid bio-inspired design ; nacre ; woodpecker beak ; mechanical performance ; failure mode ; finite element simulation ; Taguchi design ; ANOVA ; FFF ; response surface ; cylindricity ; process optimization ; polymer gear ; additive manufacturing ; differential pressure vacuum casting ; polyurethane resin ; abrasion ; fused filament fabrication ; temperature distribution modelling ; dynamic and static model ; thermal history ; impeller ; polymers ; polymer composites ; manufacturing process ; conventional manufacturing ; injection moulding ; performance ; face mask ; medical devices ; filtration performance ; 3D reconstruction ; customized implant ; PEEK ; accuracy evaluation ; finite element analysis ; 3D printing ; fused deposition modeling ; tensile testing ; infill rate ; crystallizable PET ; micromechanical model ; viscoplasticity ; temperature effect ; biaxial loading ; polylactic acid (PLA) ; dimensional deviation ; definitive screening design ; desirability function ; material extrusion ; rheological behavior ; mechanical properties ; temperature profile ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This reprint presents groundbreaking discoveries, practical techniques, and rigorous analyses related to the cultivation, preparation, and exploitation of mycelium composites. The papers cover a wide range of topics, including functional modifications of mycelium with inorganic particles, modifying and assessing the mechanical properties of mycelium composites, strategies for improving the flexural behaviour of composites, beehives from fungal materials, bio-welding and reinforcement of composites, bioreactors for fungal production, co-production of composites by fungi and bacteria, growing large-scale mycelium structures, sound absorption by composites, and the geometrical parameterisation of fungi. This informative compendium of techniques, methods, and insights on growing fungal material appeals to readers from all walks of life, from high school pupils to university professors, from mathematicians, computer scientists, and engineers to chemists, from craft practitioners to industrial producers of fungal materials, and from biologists to architects and artists.
    Keywords: mycelium-based composites ; additive manufacturing ; bio-based materials ; circular construction ; digital fabrication ; mycelium ; bio-composites ; bio-fabrication ; ultrasonic welding ; wood printing ; robotic fabrication ; reinforced composites ; natural fiber reinforced polymers ; NFRP ; growing materials ; rattan ; lightweight structure ; architecture ; structural design ; computational design ; subtractive manufacturing ; circular economy ; compressive structures ; compressive strength ; digital image correlation ; masonry ; growth ; mechanical properties ; materials science ; mycelium-based composite ; biomaterials ; natural composites ; bacterial cellulose ; biocompatibility ; knitted fabric ; material tinkering ; lignocellulosic fibers ; natural fiber reinforcement ; mechanical characteristics ; manufacturing variables ; nanoclay ; fungal fruiting bodies ; parametric design thinking ; plasticity ; linearity ; non-linearity ; biohybrid architecture ; bio fabrication ; living architecture ; beehive ; 3D printing ; mycelium materials ; symbiosis ; multispecies architecture ; healthy materials ; binding capacity ; bio-adhesives ; building biomaterials ; fungal mycelium ; mechanical performance ; acoustic materials ; sound absorption ; fungal architecture ; myceliated material ; living material ; sustainability ; biotechnology ; compression ; bending ; waste upcycling ; mycoremediation ; myco-materials ; myco-fabrication ; sustainable buildings ; sustainable structures ; architectural design ; material ethics ; modular chain bioreactor ; solid-state fermentation ; mycelium production ; Ganoderma lucidum ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Keywords: chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Keywords: neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Cement and lime currently are the most common binders in building materials. However, alternative materials and methods are needed to overcome the functional limitations and environmental footprint of conventional products. This Special Issue dedicated to “New frontiers in cementitious and lime-based materials and composites” gathers selected reviews and experimental articles that showcase the most recent trends in this multidisciplinary field. Authoritative contributions from all around the world provide important insights into all areas of research related to cementitious and lime-based materials and composites, spanning from structural engineering to geotechnics, including materials science and processing technology. This Topical Collection is intended to foster innovation and help researchers and developers to identify new solutions for a more sustainable and functional built environment.
    Keywords: durability ; hardened properties ; green composite ; fresh properties ; recycled concrete aggregates ; natural coarse aggregates ; enzyme-induced calcite precipitation ; microbial-induced calcite precipitation ; geotechnical engineering ; geoenvironmental engineering ; precast concrete wall ; interfacial bonding strength ; joint concrete ; interface processing ; washed rough surface ; roughness ; storage time ; cement mortar ; End-of-Life Tyre ; waste ; surface treatment ; compressive strength ; flexural strength ; workability ; fly ash ; freezing shaft sinking ; shaft lining structure ; uneven pressure ; hybrid fiber-reinforced concrete ; crack ; autogenous self-healing ; curing conditions ; supplementary cementitious materials (SCMs) ; GRC-PC ; integrated wall panels ; composite method ; shrinkage properties ; dissipation energy density ; high-strength concrete ; Weibull distribution ; damage mechanics ; constitutive model ; repeated impact ; ACI 544-2R ; high temperatures ; fire ; residual strength ; lime-cement mortar ; air-entrained agent ; heritage conservation ; reconstruction and restoration of historical buildings ; properties ; mechanical ; electrical resistivity ; ecofriendly ternary concrete ; SCBA ; SF ; coastal cemented soil ; nano silica ; iron tailings ; mechanical properties ; microscopic mechanism ; granite dust ; stabilizer ; particle size ; plasticity ; unconfined compression strength ; cement ; lime ; sustainable materials ; fibre-reinforced composite ; recycled aggregates ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: There is increasingly intensive research for energy storage technologies development due to the enhanced energy needs of the contemporary societies. Increased global energy consumption results in the reduction in the availability of traditional energy resources, such as coal, oil and natural gas. Therefore, there is an urgent need for new systems development based on the conversion and storage of sustainable and clean energy. Phase change materials (PCMs) are one of the key components for the development of advanced sustainable solutions in renewable energy and engineering systems. In order to update the field of renewable energy and engineering systems with the use of PCMs, a Special Issue entitled “Phase Change Materials: Design and Applications” is introduced. This book gathers and reviews the collection of ten contributions (nine articles and one review), with authors from Europe, Asia and Americam accepted for publication in the aforementioned Special Issue of Applied Sciences.
    Keywords: phase change materials ; thermal energy storage ; energy efficiency ; building applications ; construction materials ; phase-change material ; dispersion ; thermal-mechanical stability ; viscosity ; supercooling ; nucleating agent ; cold storage ; battery cooling ; LPMO ; Fourier Transform ac Voltammetry (FTacV) ; cyclic voltammetry ; Direct Electron Transfer (DET) ; lathrate hydrate ; tetrabutylammonium acrylate (TBAAc) ; crystal growth ; ultrasonic vibration ; polyurethane elastomers ; microencapsulated PCMs ; thermal properties ; mechanical properties ; phase change material ; sugar alcohol ; erythritol ; latent heat storage ; thermal stability ; degradation kinetics ; PCM ; mini-channels ; air ; melting ; solidification ; latent heat thermal energy storage ; phase change materials (PCM) ; macro-encapsulation ; rectangular slab ; experimental study ; sodium nitrate ; thermal conductivity ; microencapsulation ; latent heat ; multicriteria decision ; finite element ; automotive ; energy storage ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PH Physics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.
    Keywords: MPC polymer ; dry eye ; ocular surface ; lacrimal fluid ; mucin ; 3D bioprinting ; cornea ; retina ; ophthalmology ; tissue regeneration ; electrospinning ; conjunctiva ; decellularized tissue matrix ; small intestinal submucosa ; urinary bladder matrix ; polycaprolactone ; fiber ; tissue engineering ; stratification ; conjunctival epithelial cells ; hydrogel ; keratoplasty ; scaffold ; collagen ; advanced therapy medicinal product ; ATMP ; cell therapy ; gene therapy ; eye ; ocular ; regulatory ; marketing authorization ; double-crosslinking ; carbodiimide ; glutaraldehyde ; sodium metabisulfite ; sodium borohydride ; EDC/NHS ; stem cells ; retinal diseases ; optic nerve diseases ; cell replacement ; cell sources ; advanced therapies ; ocular mucosa ; blindness ; CLET ; limbal niche ; limbal stem cell ; LSCD ; mesenchymal stem cell transplantation ; MSCT ; corneal limbus ; decellularized xenograft ; recellularization ; mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: The scope of the Special Issue is research and reviews on evaluations of current practice, innovations in medication management, developments in therapeutics, and pharmaceutical science research that informs and improves practice and administration, as well as the social and administrative pharmacy. We will mainly feature original research, reviews, short reports, and clinical studies, but also case reports, descriptive/how-to, and commentary submissions for consideration.
    Keywords: older adults ; polypharmacy ; internal medicine ward ; community pharmacy ; drug disposal ; unused medication ; environment ; awareness ; practice ; ambulatory care facilities ; health workforce ; pharmacists ; Taiwan ; Commonwealth Partnerships for Antimicrobial Stewardship (CwPAMS) ; National Health Service (NHS) ; Chief Pharmaceutical Officer’s Global Health Fellowship ; CPhOGH Fellows ; CwPAMS ; pharmacy ; fellowship ; health partnerships ; antimicrobial resistance (AMR) ; global health ; leadership ; non-prescription medicines ; emergency contraception ; community pharmacies ; information gathering ; availability ; pricing ; mystery calls ; ulipristal acetate ; levonorgestrel ; Germany ; e-prescription ; prescription writing ; Jazan ; Saudi Arabia ; prescription errors ; medicine consumption ; defined daily dose ; adolescents and young adults ; cancer patients ; fragility ; pain ; MUR ; medication review ; barriers ; pharmacist ; pregabalin ; abuse ; community pharmacists ; reproductive health ; contraception ; emergency contraceptives ; patient education ; biosensing technology ; digital medicine system ; medication adherence ; medication event monitoring system ; nonadherence ; prescription opioids ; mortality ; standardized mortality ratio ; underlying cause of death ; prescriptions ; community pharmacy services ; emergency prescribing ; pharmacy practice ; pharmacy law and regulation ; COVID-19 ; additional monitoring ; black triangle ; adverse event reporting ; pharmacovigilance ; intervention ; outcomes ; systematic review ; pharmacy education ; decision to study in pharmacy ; selecting pharmacy as a first choice ; pharmacogenomics ; learning activity ; asynchronous learning ; virtual learning ; student survey ; Program of All-Inclusive Care for the Elderly ; adverse drug events ; medication-related problems ; drug-related problems ; medication safety ; Medicare ; Medicaid ; financial management ; pharmacy management ; business ; entrepreneurship ; pharmacy students ; perception ; attitudes ; ability ; interprofessional ; simulation ; acute care ; nursing ; students ; standardized patients ; high fidelity ; SPICE-R2 ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The trend of digitalization is an omnipresent phenomenon nowadays – in social life and in the dental community. Advancement in digital technology has fostered research into new dental materials for the use of these workflows, particularly in the field of prosthodontics and oral implantology.CAD/CAM-technology has been the game changer for the production of tooth-borne and implant-supported (monolithic) reconstructions: from optical scanning, to on-screen designing, and rapid prototyping using milling or 3D-printing. In this context, the continuous development and speedy progress in digital workflows and dental materials ensure new opportunities in dentistry.The objective of this Special Issue is to provide an update on the current knowledge with state-of-the-art theory and practical information on digital workflows to determine the uptake of technological innovations in dental materials science. In addition, emphasis is placed on identifying future research needs to manage the continuous increase in digitalization in combination with dental materials and to accomplish their clinical translation.This Special Issue welcomes all types of studies and reviews considering the perspectives of the various stakeholders with regard to digital dentistry and dental materials.
    Keywords: Dentistry ; Prosthodontics ; Implant ; dentistry ; Digital ; technology ; Dental ; materials ; Rapid ; prototyping ; CAD/CAM ; Optical ; scanning ; 3D ; printing ; Translational ; research ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Laser welding is a high-energy process used in a wide range of advanced materials to obtain micro- to macro-sized joints in both similar and dissimilar combinations. Moreover, this technique is widely used in several industries, such as automotive, aerospace, and medical industries, as well as in electrical devices. Although laser welding has been used for several decades, significant and exciting innovations often arise from both the process and/or advanced materials side.
    Keywords: TA1-2040 ; T1-995 ; n/a ; tensile strength ; microstructure ; aided electric current ; stainless steel ; accuracy ; porosity control ; laser offset welding ; T-joint ; BTi-6431S ; dissimilar metal ; finite element method ; weld pool behavior ; dissimilar welding ; WPP ; laser welds ; HLAW ; fiber laser ; steel S700MC ; conduction regime ; liquid metal ; buy-to-fly ; EBSD phase mapping ; mass transfer ; mechanical properties ; hardness ; MAG ; phase transformation ; prediction ; LKW ; Ti-5Al-5V-5Mo-3Cr ; laser beam ; laser welding-brazing ; DP1000 steel ; Ti–6Al–4V ; titanium ; low alloyed steel ; H-shaped fusion zone ; pulsed Nd:YAG laser beam welding ; spatter ; high-speed imaging ; weld morphology ; high temperature titanium alloy ; Al/steel joints ; hybrid welding ; dissimilar material ; laser beam welding ; intermetallic layer ; WW ; L-joint ; penetration ; laser stake welding ; laser keyhole welding ; trip steel ; finite element analysis ; laser welding ; magnesium alloy thin sheet ; keyhole ; tensile properties ; dissimilar joining ; IMC layers ; SKM ; fiber laser welding ; aluminium ; dual phase steel ; aluminum alloy T-joint ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.
    Keywords: R5-920 ; RC620-627 ; gluten ; n/a ; mental health ; 33-mer ; gut motility ; gluten re-introduction ; teenagers ; gastric emptying ; islet of Langerhans ; children ; high-fat diet-induced obesity ; affective disorders ; FODMAP intake ; Brazilian CD-QoL ; DQ2.5-glia-?3 epitopes ; place of residence ; zinc ; glutenin ; quality of life (QoL) ; mood disorders ; magnesium ; dietary adherence ; coeliac disease ; food habit ; villous atrophy ; pepsin ; peptides derived from gluten in faeces and urine ; beta cell ; body mass index (BMI) ; oral food challenge ; gliadin ; ?-gliadin ; non-celiac gluten sensitivity ; celiac disease ; wheat ; outcome ; DQ2.5-glia-?1 ; DQ2.5-glia-?2 ; gut microbiota ; type 2 diabetes ; major depressive disorder ; micronutrient ; beta-cell stress ; non-coeliac gluten sensitivity ; screening ; gluten free diet ; gluten-related disorders ; threshold ; diary recommended intake ; wheat species ; non-coeliac wheat sensitivity ; body composition ; serology ; educational level ; mineral ; disease duration ; gastrointestinal symptoms ; gluten-free diet ; NOD mouse ; diagnosis ; osteoporosis ; nutrition ; cholecyst ; wheat allergy ; celiac disease (CD) ; quality of life ; microbiota ; questionnaire ; nutritionists ; structured questionnaires ; Pseudomonas ; intestinal permeability ; Celiac Disease ; economic status ; effectiveness ; type 1 diabetes ; cost ; calcium ; irritable bowel syndrome ; adherence ; non celiac gluten sensitivity ; deficiency ; gluten sensitivity ; iron ; low FODMAP diet ; depression ; clinic ; duodenal biopsies ; fortification ; mucosal recovery ; bic Book Industry Communication::M Medicine
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    Publication Date: 2023-12-21
    Description: The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
    Keywords: R5-920 ; TA1-2040 ; RM1-950 ; fiber optic sensor ; computational optical sensing and imaging ; imaging spectroscopy ; spectral imaging ; optical coherent tomography ; optical feedback interferometry ; optical tomography ; Raman sensing and imaging ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Rare diseases, or orphan diseases, are those that individually affect a small number of patients, but taken together affect over 300 million people worldwide. They are characterized by their etiological, diagnostic and evolutionary complexity, important morbi-mortality, with high levels of disability that entail and hinder the development of a normal vital subject, not only in those who suffer from them, but also their families; therefore, a comprehensive social health approach is necessary to address this problem.About 80% of rare diseases have a genetic origin, mainly monogenic; thus, genetic testing is mandatory for the confirmation of clinical diagnostics and to ensure correct genetic counseling. Next-generation sequencing (NGS) has enabled a revolution in genetic diseases, specially in rare diseases. However, their complexity makes diagnoses difficult even with the advent of NGS.In this Special Issue, we present several examples of the complexity of genetic diagnosis for most of these diseases and the consequences that genetic testing implies for genetic counseling. There are examples of the genetic heterogeneity of hearing loss, some metabolic and lisosomal disorders, ataxia, Prader–Willi syndrome, and three comprehensive reviews on syndromic retinal dystrophies, the complexity of the molecular diagnosis of neuromuscular disorders, and the value of genetic counseling before and after a genetic test.
    Keywords: retina ; inherited retinal diseases ; syndrome ; Turner syndrome ; mosaicism ; ring chromosomes ; growth hormone deficiency ; pituitary microadenoma ; clinical genetics ; early onset ataxia ; dystonia ; neurodevelopment ; network analysis ; bioinformatics ; ataxia ; phenotype ; child ; NGS ; next generation sequencing ; inborn errors of metabolism ; lysosomal disorders ; neuromuscular disease ; genetic testing ; whole exome sequencing ; Prader–Willi syndrome ; imprinting disorder ; recombinant human growth hormone ; insulin-like growth factor 1 ; HMGLD ; HMGCL ; HMG-CoA lyase deficiency ; inherited metabolic diseases ; familial hearing loss ; multiple diagnoses ; non-syndromic hearing loss ; ACTG1 ; MYH9 ; genetic counselling ; rare diseases ; professional recognition ; hearing loss ; genetic diagnosis ; SLC26A4 ; DFNB4 ; Tuvinians ; Altaians ; Southern Siberia ; Russia ; GSDME ; DFNA5 ; single-exon CNV ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Wood composites have shown very good performance, and substantial service lives when correctly specified for the exposure risks present. Selection of an appropriate product for the job should be accompanied by decisions about the appropriate protection, whether this is by design, by preservative treatment or by wood modification techniques. This Special Issue, Advances in Wood Composites presents recent progress in enhancing and refining the performance and properties of wood composites by chemical and thermal modification and the application of smart nanomaterials, which have made them a particular area of interest for researchers. In addition, it reviews some important aspects in the field of wood composites, with particular focus on their materials, applications, and engineering and scientific advances, including solutions inspired biomimetrically by the structure of wood and wood composites. This Special Issue, with a collection of 13 original contributions, provides selected examples of recent Advances in Wood Composites
    Keywords: TA1-2040 ; T1-995 ; shear strength ; n/a ; buckling ; thermal property ; acetic anhydride ; WPC ; silicon carbide ; coating amount ; composite ; polymer-triticale boards ; wood ; activation volume ; oriented strand lumber (OSL) ; bending strength ; nanowollastonite ; VOCs ; wood-inorganic composites ; thermal modification ; wood plastic composite ; crystallinity ; sol-gel process ; wood adhesive ; straw ; mechanical properties ; bamboo ; plastic ; carbothermal reduction ; formaldehyde emissions ; cellulose ; graphene nano-platelets ; creep behavior ; surface properties ; dimensional stability ; nanocompounds ; UF resin ; tunnel-structured ; ceramic ; color ; water absorption ; high-density polyethylene film ; mechanical property ; aquacultural ; HDPE ; biorefinery lignin ; methyl methacrylate ; structural analysis ; sol–gel process ; polyurethane-acrylate ; mechanical and physical properties ; water-based UV curing coating ; oak (Quercus alba L.) ; dynamic thermodynamic ; stepped isostress method ; thermoplastic polymers ; sustainable adhesives ; finite element analysis ; rapid formaldehyde release ; adhesive penetration ; modulus of elasticity in bending ; Southwell’s method ; hydrophobicity ; Abaqus ; sepiolite ; chemical structure ; alder plywood ; wood panels ; particleboard properties ; chemical modification ; thickness swelling ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This book presents a collection of papers revealing the impact of advanced computation and instrumentation on healthcare. It highlights the increasing global trend driving innovation for a new era of multifunctional technologies for personalized digital healthcare. Moreover, it highlights that contemporary research on healthcare is performed on a multidisciplinary basis comprising computational engineering, biomedicine, biomedical engineering, electronic engineering, and automation engineering, among other areas.
    Keywords: eHealth ; mHealth ; telemedicine ; telehealth ; social sciences ; bibliometrics ; telediagnostic ; project management ; funding ; IT infrastructure ; cross-border multiprofessional team ; European Union ; Interreg ; reporting ; quality control ; resident ; diagnostic error ; artificial intelligence ; healthcare AI ; deployment and scaling ; medical center ; critical factors ; stakeholders ; health information technology ; information sharing ; hospital costs ; poverty ratio ; concentration ; continuous glucose monitoring ; insulin pump ; continuous subcutaneous insulin infusion ; pediatric diabetes ; biomedical data ; medical imaging ; shared data ; massive databases ; AI-based healthcare solutions ; trueness ; 3D printing ; milling ; interim dental crown ; digital dentistry ; dental device ; data mining ; bio-signal analysis ; bio-signal repository ; execution engine ; bio-signal monitoring ; digital healthcare ; patient-centric ; blockchain ; federated learning ; coronavirus (COVID-19) ; pandemic management ; healthcare transformation ; public health strategies ; stroke detection ; portable head scanner ; low-intensity EM waves ; intrinsically safe ; low carbon footprint ; orthodontic treatment ; clear aligners ; smart application ; AI ; computerized learning ; behavior change techniques ; decision tree algorithm ; digital interventions ; mental health literacy ; audiovisual ; dentistry ; computer-controlled local anesthetic delivery ; ultrasounds ; chemomechanical caries removal ; modern technologies ; laser ; ozone ; healthcare ; emergency department ; patient flow ; simulation modeling ; agent-based modeling ; pandemic decision support ; additive manufacturing ; patient-centric dosage form ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Supporting initiation, development and resolution of appropriate immune responses is key to survival. Many nutrients and dietary components have been purported to have a role in supporting optimal immune function. This is vital throughout the life course, from the development and programming of the immune system in early life, to supporting immunity and reducing chronic inflammation in older people. In this special issue of Nutrients, we examine the evidence for the role of diet and dietary components in promoting protective immunity.
    Keywords: R5-920 ; RC581-607 ; immunonutrition ; supplementation ; superoxide dismutase (SOD) ; fermented milk ; selenocysteine ; dendritic cells ; lipoxygenase (LOX) ; chronic inflammatory conditions ; formulation ; immune system ; cytokines ; skeletal muscle ; zinc ; non-digestible carbohydrates ; Toll-like receptor ; carbohydrates ; fiber ; lymphocytes ; antibody ; infants ; liver ; macrophage ; inflammatory process ; probiotic ; plant ; older people ; gut barrier ; infection ; amino acids ; gut ; T helper 1 (Th1) ; immunity ; T cells ; bioactive peptide ; inhibitor of kappa kinase (IKK) ; inflammation ; adhesion molecules ; leukocytes ; human milk oligosaccharides ; vitamin D ; food structure ; vitamin E ; mitogen-activated protein Kinase (MAPK) ; gut microbiota ; weaning ; homeostasis ; intestinal immune system ; extra-cellular signal regulated kinases (ERK) ; cyclooxygenase (COX) ; oxidative stress ; life course ; polyphenols ; oligosaccharides ; micronutrients ; Th17 ; obesity ; tolerance ; arachidonic acid ; growth factors ; anti-inflammation ; age-related immunity ; prebiotic ; biomarker ; microbiome ; functional foods ; immunosenescence ; nutrition ; molecular mechanisms ; metabolism ; macronutrients ; toll-like receptor 4 ; sepsis ; nutrition guidelines ; microbiota ; immunomodulation ; inflammatory markers ; elderly ; Th1/Th17 response ; adults ; reactive oxygen species (ROS) ; anorexia nervosa ; macrophages ; autoimmune diseases ; fatty acids ; T cell ; Treg ; breast milk ; nitric oxide synthase (NOS) ; chemokines ; anti-tumorigenic ; metabolites ; deficiency ; protein hydrolysate ; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) ; cancer ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In the last decade, design and material innovations for manufacturing composites have reached new heights. Thermoplastic polymers and their composites have become the most in-demand materials in recent times as they provide numerous advantages over thermoset composites. Thermoplastic polymers have a high damage tolerance, high impact resistance, recyclability, formability, weldability, repairability, and cost-effectiveness compared with thermoset composites. Thermoplastic polymers and composites are widely used in automotive, aerospace, electrical and electronics, industrial, and medical applications. Thermoplastic composites are estimated to grow from USD 28.0 billion in 2019 to USD 36.0 billion by 2024. High-performance thermoplastic materials are used in conjunction with a multitude of manufacturing processes like injection moulding, thermoforming, prepreg, liquid injection processes, automated tape placement, filament winding, pultrusion, additive manufacturing, and other processes. The material limits, design, and assembly requirements, as well as the processing constraints, are significantly important for the realisation of novel product development using a manufacturing process by simultaneously optimising reliability, safety, and other performance-related issues. The current thermoplastic material systems and manufacturing techniques still have plenty of room for optimisation and advancement. This reprint presents the latest scientific and technical advances in thermoplastic materials and their composites, processing, characterisation, product development, and manufacturing process parameter optimisations.
    Keywords: thermoplastic composites ; automated tape placement ; fibre misalignment ; voids ; CT scan ; circular distribution ; textured surface ; scratch ; scratch resistance ; thermoplastic polymer ; finite element modelling ; antimicrobial ; metallic ions ; ligand ; copper nanoparticles ; polypropylene ; thermoplastic resin ; process modeling ; filament winding ; automated fiber placement ; EWF ; polymer-layered silicates ; oMMT ; clay minerals ; mechanical properties ; nanocomposite ; physio-thermo-mechanical properties ; polyurethane ; polymers ; bio-applications ; energetic binder ; block copolyurethane ; sensitivity ; mechanical property ; thermal behavior ; bone scaffold ; recycled bone powder ; chitosan ; PLA ; PCL ; antibacterial activity ; aircraft cabin interior panels ; optimal curing of prepregs ; foams ; non-structural composite panels ; thermoplastic starch ; nanocomposites ; biopolymers ; properties ; packaging ; nanofiller ; vacuum forming ; thermoplastic face sheets ; polyphenylene sulfone ; cardo fragments ; IR spectroscopy ; heat resistance ; thermostability ; FDM ; oil palm fiber ; ABS ; rheology ; 4D printing ; material programming ; digital fabrication ; shape-memory polymers ; PPS ; carbon nanotubes ; thermal analysis ; electrical properties ; rheological properties ; resin transfer molding ; non-crimp fabrics ; consolidation ; ultra-high molecular weight component ; rheological property ; crystallization behavior ; polyimide foam ; rigid closed-cell foam ; high temperature ; benzimidazole ; polyamide 12 ; carbon nanofiller ; carbon nanotube ; graphene nanoplatelet ; 3D printing ; thermal conductivity ; compound ; fluorinated aromatic polyimide ; low dielectric loss ; molecular chain orientation ; molecular dynamics simulation ; long-fiber-reinforced thermoplastic ; fiber length ; fiber orientation ; injection molding ; hollow composite tubes ; bending ; failure mechanisms ; in situ consolidation ; void content ; processing parameters ; thermosetting resins ; thermoplastics ; co-bonding ; interphase ; diffusion ; adhesion ; phosphorescent composites ; compatibilizer ; thermal and mechanical ; composite ; thermoplastic ; thermoforming ; simulation ; Taguchi ; DOE ; oil palm fiber composites ; 3D composites ; thermoset ; off-axis flexure behaviour ; on-axis flexure behaviour ; hybrid fibers ; hybrid composites ; vacuum assisted resin infusion (VARI) ; fracture toughness ; fractography ; reinforcements ; thermal properties ; biobased polymer composites ; polymer modification ; PBAT ; starch ; microcrystalline cellulose ; biodegradable ; polyethylene glycol ; poly(butylene adipate-co-terephthalate) ; supercritical CO2 ; foam ; thermoplastic matrix composites ; impregnation processes ; manufacturing ; fiber reinforced ; processing ; retrogradation ; extrusion ; co-plasticization ; isosorbide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: This book was proposed and organized as a means to present recent developments in the field of testing of materials and elements in civil engineering. For this reason, the articles highlighted in this editorial relate to different aspects of testing of different materials and elements in civil engineering, from building materials to building structures. The current trend in the development of testing of materials and elements in civil engineering is mainly concerned with the detection of flaws and defects in concrete elements and structures, and acoustic methods predominate in this field. As in medicine, the trend is towards designing test equipment that allows one to obtain a picture of the inside of the tested element and materials. Interesting results with significance for building practices were obtained.
    Keywords: rock bolt ; grouting quality ; dynamic response ; natural frequency ; finite element method ; monitoring ; historical masonry wall ; hygrothermal processes ; internal insulation ; testing of building materials ; test uncertainty ; validation of test methods ; sustainable test methods ; recycling ; foamed asphalt mixtures with cement (FAC) ; base layer ; reclaimed asphalt pavement (RAP) ; fatigue durability ; GFRP ; FRP reinforcement ; shear ; capacity ; reinforced concrete beams ; column ; stiffness ; FRCM ; PBO mesh ; PBO–FRCM ; carpentry joints ; scarf and splice joints ; stop-splayed scarf joints (‘bolt of lightning’) ; static behaviour ; experimental research ; concrete ; non-destructive testing ; ultrasounds ; ultrasonic tomography ; acoustic methods ; defects ; diagnostic ; detection ; convolutional neural networks ; transfer learning ; monitoring FBG ; power transmission tower ; civil engineering ; X-ray microtomography ; microstructure characteristics ; infiltration damage ; high-strength concrete ; steel fibres ; flexural tensile strength ; fracture energy ; numerical analysis ; concrete floors ; compressive strength ; strength distribution ; industrial floors ; ultrasound tests ; ventilated facades ; large-scale facade model ; fire safety ; fiber cement board ; large-slab ceramic tile ; plasterboards ; moisture content ; hydration processes ; mechanical properties ; ultrasound measurements ; ESD resin ; expansion joint ; quasi-plastic material ; energy absorption ; asphalt mix ; compaction index ; volumetric parameters ; stiffness modulus ; moisture resistance ; roughness ; texture ; close-range photogrammetry ; bond strength ; random field generation ; semivariograms ; hybrid truss bridge ; steel–concrete connection joint ; mechanical behavior ; failure mode ; strain ; static test ; static elastic modulus ; dynamic elastic modulus ; machine learning ; P-wave ; S-wave ; resonance frequency test ; nondestructive method ; Al–Ti laminate ; fracture ; acoustic emission diagnostic ; pattern recognition ; clustering AE signal ; storage systems ; tab connector ; flexural test ; capable design moment ; restrained ring test ; autogenous shrinkage cracking ; concrete cracking test ; concrete shrinkage cracking test ; restrined ring calibration ; cement–fiber boards ; acoustic emission method ; k-means algorithm ; wavelet analysis ; fiber composites ; ground penetrating radar (GPR) ; HMA dielectric constant ; road pavement thickness estimation ; early age concrete ; damage processes detection before loading ; strength of structures ; aggregate ; classification ; wire mesh ; roundness ; tilting angle ; opening size ; concrete centrifugation ; morphology ; image processing ; porosity ; cement ; waste paper sludge ash (WPSA) ; controlled low-strength material (CLSM) ; unconfined compressive strength ; bearing capacity ; backfill material ; P-wave velocity ; amplitude attenuation ; resistivity ; CT scan ; sandstone ; damage variable ; nuclear magnetic resonance ; spin-lattice relaxometry ; proton ; hydration kinetics ; superplasticizer ; ready-mixed concrete ; construction material ; quality assessment ; conformity criteria ; statistical-fuzzy method ; FRTP ; rivet ; connection ; polyethylene pipe ; mechanical properties of polyethylene ; resistance strain ; computer simulation ; residual shear stress ; particle crushing ; ring shear test ; particle flow code (PFC2D) ; frictional work ; fibre-reinforced concrete ; recycled steel fibres ; micro-computed tomography ; scanning electron microscopy ; tensile strength ; reinforced concrete ; diagnostic testing ; corrosion ; carbonation ; galvanostatic pulse method ; phase composition analysis ; X-ray analysis ; thermal analysis ; quasi-brittle cement composites ; low-module polypropylene fibres ; elastic range ; digital image correlation ; Arcan shear test ; wood ; orthotropic shear modulus ; elastic-plastic material ; shear wave velocity ; sand ; bender elements test ; grain-size characteristics ; complex modulus ; shrinkage analysis ; reclaimed asphalt ; mineral–cement emulsion mixtures ; cement dusty by-products (UCPPs) ; degradation of glass panels ; effective area ratio ; relative mass loss ; visible light transmittance ; windblown sand ; wood-plastic composites ; methods of testing resistance to fungi ; methods of assessment ; ground-penetrating radar (GPR) ; non-destructive techniques (NDT) ; corrosion of reinforcement ; slip resistance ; granite floor ; slip resistance value ; ramp test ; acceptance angle ; sliding friction coefficient ; comparability of test methods ; wall temperature ; fibre bragg grating sensors ; freeze-thaw cycles ; signal analysis ; short-time Fourier transform ; fast Fourier transform ; brine ; sodium chloride ; X-ray ; partition walls ; brick walls ; bending strength ; cracking ; post-tension ; cable ; girder ; destructive test ; non-destructive test ; structural health monitoring ; safety ; monitoring fibre Bragg grating ; mining areas ; strain/stress distribution ; geopolymer concrete ; fly-ash ; bottom-ash ; neural network ; sustainability ; industrial waste management ; flexural strength ; cladding ; AE acoustic emission ; micro-events ; sound spectrum ; traditional and quasi-brittle cement composites ; residual-state creep ; saturation front ; landslides ; erosional stability ; laboratory testing ; grout mixtures ; groundwater ; test apparatus ; testing ; building materials ; elements ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: As we know, strokes are one of the world's leading causes of death, and the cruel aspect of a stroke is that it leaves people with severe functional disability and/or cognitive impairment. Strokes have a significant impact on economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are affected by them. Such people need personal help in their everyday life and must be materially supported by social services. With the advancement of medicine, artificial intelligence, and new technologies have been developing rapidly and are gradually applied in diseases of the nervous system, increasingly helping diagnosis, treatment, rehabilitation, and prognosis of disease.This Special Issue has collected the 14 papers on artificial intelligence and new technologies in strokes, including in the aspects of diagnosis, treatment, prognosis, rehabilitation, and nursing. We welcome your reading.
    Keywords: non-invasive brain stimulation ; stroke ; spasticity ; meta-analysis ; hemiplegia ; electromyographic bridge ; upper limb rehabilitation ; randomized controlled trial ; hypoxic ischemic encephalopathy ; disorders of consciousness ; metabolic connectivity ; positron emission tomography ; 18F-fluorodeoxyglucose ; hand function rehabilitation ; hand rehabilitation robot ; computer vision technology ; wearable devices ; sensors ; artificial intelligence ; brain–computer interface ; active rehabilitation training ; motor function ; brain function ; executive function ; postural control ; gait ; repetitive transcranial stimulation ; facial paralysis ; peripheral magnetic stimulation ; blood flows ; laser speckle ; stroke rehabilitation ; upper limb ; automated system ; motor function assessment ; Fugl-Meyer Assessment ; motor attempt (MA) ; EEG ; deep learning method ; overlapping time window ; facial expression recognition (FER) ; vision transformer (ViT) ; convolutional neural networks (CNNs) ; rehabilitation ; assessment ; upper extremity ; hand ; brain–computer interfaces ; motor task ; sensorimotor rhythm ; hand rehabilitation ; motor imagery ; virtual reality ; rTMS ; DTI ; immersive virtual reality ; post-stroke cognitive impairment ; aging ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars.
    Keywords: hyperbaric oxygen therapy (HBOT) ; Hyperoxia ; wound healing ; antimicrobial properties ; Coronavirus Disease-19 (COVID-19) ; critical flicker fusion frequency ; threshold of flicker fusion ; neuropsychology ; diving and hyperbaric medicine ; minimal hepatic encephalopathy ; diabetes ; hyperbaric oxygen therapy ; glycaemia ; oxygen ; hyperbaric oxygen ; epigenetics ; normobaric oxygen paradox ; hyperoxic-hypoxic paradox ; frostbite ; classification ; cold disease ; prognosis ; amputation ; medical outcome ; atmosphere exposure chambers ; diving physiology ; decompression ; periodontal disease ; oral health index ; dental mobility ; periodontal pockets depth ; subfoveal choroidal thickness ; intraocular pressure ; central corneal thickness ; central serous chorioretinopathy ; flow-mediated dilation ; arterial stiffness ; endothelial dysfunction ; n/a ; FMD ; underwater ; hyperbaric ; commercial diver ; off-shore energy operation ; human ; adverse effects ; autonomic nervous system ; lung ultrasound ; mixed gas diving ; pulmonary function ; technical diving ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Nano/micro-size particles are widely applied in various fields. Among the various particles, silver particles are considered among the most prominent nanomaterials in the biomedical and industrial sectors because of their favorable physical, chemical, and biological characteristics. Thus, numerous studies have been conducted to evaluate their properties and utilize them in various applications, such as diagnostics, anti-bacterial and anti-cancer therapeutics, and optoelectronics. The properties of silver particles are strongly influenced by their size, morphological shape, and surface characteristics, which can be modified by diverse synthetic methods, reducing agents, and stabilizers. This Special Issue provides a range of original contributions detailing the synthesis, modification, properties, and applications of silver materials. Nine outstanding papers describing examples of the most recent advances in silver nano/microparticles are included. Silver nano/micro-size particles have many potential advantages as next-generation materials in various areas, including nanomedicine. This Special Issue might be helpful to understand the value of silver particles in the biomedical and industrial fields
    Keywords: TA1-2040 ; T1-995 ; n/a ; membrane ; bacteria ; cyclodextrin ; silver nanomaterial ; drug delivery ; transparent conductive film ; cytocompatibility ; surface free energy ; administration route ; sericin ; biosensor ; uptake ; substrate modification ; silver ion ; AgNPs ; mechanical properties ; cell culture ; titanium alloy ; Au–Ag alloy ; silver shell ; moderate sintering ; wound dressing ; polymer nanocomposite ; DNA damage ; surface morphology ; reactive oxygen species (ROS) ; flexible and printed electronics ; plants ; reactive oxygen species ; mechanism ; optoelectronics ; cytotoxicity ; photonic sintering ; synthesis ; silver nanoparticle ; doxorubicin (DOX) ; food packaging ; SERS detection ; nanomedicine ; antimicrobial activity ; nanogaps ; TNFR1 ; silica template ; silver ions release ; diagnostics ; phytotoxicity ; polydopamine ; silver nanoparticles ; tumor necrosis factor ; protective agent ; characterization ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In response to the demanding requirements of different sectors, such as construction, transportation, energy, manufacturing, and mining, new generations of microalloyed steels are being developed and brought to market. The addition of microalloying elements, such as niobium, vanadium, titanium, boron, and/or molybdenum, has become a key tool in the steel industry to reach economically-viable grades with increasingly higher mechanical strength, toughness, good formability, and weldable products. The challenges that microalloying steel production faces can be solved with a deeper understanding of the effects that these microalloying additions and combinations of them have during the different steps of the steelmaking process.
    Keywords: niobium microalloyed steel ; as-cast condition ; inclusion ; rare earth elements ; precipitation. ; steel ; thermomechanical processing ; microstructure characterisation ; mechanical properties ; molybdenum ; martensitic steel ; direct quenching ; microalloying ; hardenability ; toughness ; grain refinement ; Hall–Petch coefficient ; microalloy precipitates ; hydrogen embrittlement ; Ti-Mo steel ; hot deformation ; constitutive model ; microstructural evolution ; microalloyed steels ; processing ; microstructural and chemical composition ; micro-alloyed steels ; precipitations ; Zener pinning ; atomic force microscopy (AFM) ; precipitation-microstructure correlation ; EBSD ; reconstruction methods ; continuous casting ; energy absorption ; mechanical metallurgy ; niobium ; reheat process ; thermo-mechanical controlled processing ; plate rolling ; strengthening ; precipitation ; induction ; titanium ; advanced high strength steels ; HSLA steels ; precipitation strengthening ; tempering ; bainitic ferrite ; austenite-to-ferrite transformation ; hot-torsion test ; coiling simulation ; medium-carbon steel ; strength and toughness ; austenite ; abnormal grain growth ; cold-deformation ; precipitate ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: The year 2021 saw the publication of the Special Issue “"Diseases of the Salivary Glands" (https://www.mdpi.com/journal/jcm/special_issues/Salivary_Glands), Part I, covering recent and novel advancements as well as future trends in the field of research evaluating diagnostic and therapeutic treatment of salivary gland (SGs) diseases. Given the enormous success of Part I, the Special Issue “Diseases of the Salivary Glands” Part II has been launched, with the firm belief that it will enrich the panorama of world research in this field. Topics include: 1) Clinical features and presentation of potentially malignant SG disorders; 2) Risk factors and etiopathogenesis of SGs tumors; 3) Etiopathogenesis and molecular mechanisms involved in the chronic inflammatory condition characterizing Sjӧgren’s syndrome; 4) New discoveries in the field of micro RNAs associated with Sjӧgren’s syndrome; 5) Molecular markers linked to development and progression of SG diseases: current knowledge and future implications; 6) More innovative techniques for the study of the SG diseases: current limitations and future directions.
    Keywords: xerostomia ; dry mouth ; protein–protein interaction ; drug target ; head and neck cancer ; Sjögren’s Syndrome ; major histocompatibility complex (MHC) ; human leukocyte antigen (HLA) ; autoantigens ; T cells ; E-cadherins ; salivary glands ; morphogenesis ; EMT ; Sjögren’s syndrome ; autoimmunity ; hydrogen peroxide ; adrenaline ; blood loss ; tonsillectomy ; fibrosis ; pleomorphic adenoma ; epithelial–mesenchymal transition ; carcinoma ex-pleomorphic adenoma ; 99mTc-interleukin-2 ; activated lymphocytes ; inflammation imaging ; Sjögren syndrome ; nuclear medicine ; radiopharmaceuticals ; PET ; SPECT ; Follistatin-like 1 protein ; TGF-β1 ; SMAD2/3 ; fluoride ; sodium fluoride ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.
    Keywords: R5-920 ; RM1-950 ; antibacterial activity ; piroxicam ; n/a ; tissue engineering ; biotechnology ; polydextrose ; solvent casting ; antibacterial ; drug delivery ; diabetic ; pectin ; nanotechnology ; nanocomposite ; hydroxypropyl methyl cellulose ; poorly water-soluble drug ; artificial red blood cells ; oral dosage form ; Lactobacillus ; scanning electron microscopy ; wound healing ; UV imaging ; wetting ; biocompatibility ; scale-up ; polylactide-co-polycaprolactone ; nanofibers ; growth factor ; drug release kinetics ; hydrogel ; differential scanning calorimetry ; bacterial bioreporters ; physical solid-state properties ; PCL ; coaxial spinning ; drug delivery system ; haemanthamine ; probiotics ; amphiphilic nanofibers ; wound dressings ; grinding ; scanning white light interferometry ; biopharmaceuticals ; clove essential oil ; viability ; plant-origin alkaloid ; oligochitosan ; local delivery ; electrospinning ; Lactococcus ; self-assembled liposomes ; microcapsules ; microfibers ; nanofiber ; in situ drug release ; biomedical ; core-sheath nanofibers ; processability ; polymeric carrier ; aceclofenac ; drying ; gentamicin sulfate ; traditional electrospinning ; electrospinning and electrospray ; fourier transform infrared spectroscopy ; drug release ; gelatin ; ultrasound-enhanced electrospinning ; 3D printing ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
    Keywords: bone ; collagen type I ; alginate ; conditioned medium ; viability ; MSC ; osteogenesis ; pulsed electromagnetic field ; osteogenic factors ; wool keratin scaffolds ; bone tissue engineering ; biocompatibility ; biomaterials ; bone augmentation ; bone conduction ; bone grafting ; calcium hydroxyapatite ; tissue regeneration ; dental implants ; osseointegration ; osteoporosis ; zoledronate ; animal model ; titanium membrane ; titanium foil ; occlusive titanium barrier ; guided bone regeneration ; osteoporotic condition ; xenograft ; bone regeneration ; titanium implants ; additive manufacturing ; reused powder ; unit cell topology ; tissue engineering ; mechanical properties ; stem cells ; surface functionalization ; titanium ; protein adsorption ; surface modifications ; cell interactions ; collagen hydrogel ; cell delivery ; olfactory ectomesenchyme stem cells ; bioactive glasses ; alkali-free ; sol–gel ; bone remodeling ; bone disorders ; biomechanics ; scaffolds ; microenvironment ; 3D bioprinting ; computational modeling ; bone implant ; bone defects ; chitosan ; degree of deacetylation ; bone formation ; X-ray micro CT ; histology ; sheep tibia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint focuses on the current progress in sports medicine, with a specific interest in surgery, exercise therapy, and multi-disciplinary research. With the advancement of society, more attention is paid to the quality of life, which emphasizes the importance of sports and exercise. Correspondingly, there is a great need for sports medicine. This issue collected novel findings on sports medicine in surgery, conservative therapy, and the application of exercise training in other disorders
    Keywords: shoulder ; rotator cuff ; allografts ; demineralized bone matrix ; biologics ; diabetes mellitus ; aerobic training ; resistance training ; vascular function ; meta-analysis ; femoroacetabular impingement ; hip arthroscopy ; longitudinal capsulotomy ; femoroplasty ; labrum repair ; degenerative lumbar diseases ; albumin-to-alkaline phosphatase ratio ; spinal fusion rate ; prognostic marker ; arterial hypertension ; exercise hypertension ; blood pressure ; exercise testing ; sports injuries ; machine learning ; injury prediction ; sports monitorization ; elite football ; performance ; systemic inflammation ; physical endurance ; physical fitness ; maximal aerobic capacity ; gingivitis ; cardiac rehabilitation ; exercise therapy ; balance exercises ; cardiovascular diseases ; ACLR ; hamstring tendon with preserved tibial insertion ; MRI ; T2 ; cartilage volume ; gait retraining ; running-related injuries ; kinetics ; kinematics ; rehabilitation ; rotator cuff tear ; rotator cuff repair ; bone quality ; osteopenia ; osteoporosis ; anchor pullout ; pullout strength ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells.
    Keywords: Breast cancer treatment ; Photodynamic therapy ; Inorganic nanoparticles ; Active targeting ; cathepsins ; BAX ; MOMP ; ubiquitination ; apoptosis ; chemotherapy ; cancer ; nanoerythrosome ; nanoerythrocyte ; nanovesicles ; biomimetic ; cancer therapy ; diagnostics ; imaging agents ; cell cycle ; cyclin-dependent kinase ; p16 ; p21 ; p27 ; breast cancer ; prognosis ; drug delivery ; HL60 ; leukemia ; prodrug ; resistance ; retinoic acid ; vitamin K ; drug repurposing ; COVID-19 ; pandemic ; vaccination ; multi-drug resistance ; enhanced permeation and retention effect ; nanotherapeutics ; cancer theranostic ; clinical translation ; cell-penetrating peptides ; protein transduction domains ; tumor imaging ; targeted therapies ; dog ; comparative oncology ; molecular targets ; spheroids ; tumoroids ; hydrogel ; collagen ; agarose ; mammary spheroids ; tissue engineering ; cisplatin ; melanoma ; melanin nanoparticles ; cytotoxicity ; laser medical applications ; hyperthermia ; antimitotics ; mitotic slippage ; spindle assembly checkpoint ; clinical trials ; TRAIL ; cancer stem cells ; TRAIL resistance ; angiogenesis ; on-demand drug delivery systems ; electrospun nanofibers ; poly (N-isopropylacrylamide) ; gold nanorods ; paclitaxel ; β-Cyclodextrin ; SPIONs ; metallodrugs ; RAPTA derivatives ; phosphino-amine ligands ; CTCs ; NSCLCs ; metastasis suppression ; curcumin ; flavonoids ; TNBC ; immunotherapy ; immune checkpoint ; nanocarrier ; combinational immunotherapy ; lung cancer ; miRNA ; oncomiRs ; photodynamic therapy PDT ; porphyrin ; iron oxide nanoparticles ; mesoporous silica nanoparticles ; antibody functionalization ; targeted drug delivery systems ; molecular-targeted therapies ; multifunctional enzymes ; HCC ; CHRNA5 ; metastasis ; stemness property ; sorafenib sensitivity ; neoantigens ; vaccine ; Patched ; chemotherapy resistance ; metastases ; persistent cells ; adrenocortical carcinoma ; BUB3 ; mitosis ; senescence ; anticancer target ; boron neutron capture therapy ; 4-borono-l-phenylalanine ; drug discovery ; solubility ; mebendazole ; polymer ; HPMA ; controlled drug release ; PLK1 ; BI2536 ; Navitoclax ; slippage ; PD-1 ; gemcitabine ; new anti-cancer drugs ; precision medicine ; undruggable targets ; non-coding RNAs ; oligonucleotide therapeutics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow, or, in any case, go hand in hand with the creation and the development of innovative and higher performing materials, instruments, and equipment. Thanks to contemporary applications of dental materials, the effectiveness of clinical dentistry has made remarkable advances. In recent years, thanks to digital technology and the frenetic development of the dental industry, new materials have been developed and proposed in many fields of dentistry: prosthesis, restorative dentistry, endodontics, implantology, and orthodontics. Unfortunately, as often happens, this productive challenge is not always accompanied by valid scientific research, and consequently the clinician finds new materials at their disposal that are not necessarily better than the old. Further studies are needed to gain relevant evidence for all recently introduced dental materials. This reprint includes research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.
    Keywords: MIH ; hypersensitivity ; enamel infiltration ; hypomineralization ; marginal adaptation ; fixed partial denture ; dental technology ; cobalt–chromium alloys ; scanning electron microscopy ; titanium ; dental implants ; hydrophilic ; hydrocarbon ; biological ageing ; UV photofunctionalization ; alveolar bone defects ; guided bone regeneration ; titanium meshes ; customized titanium meshes ; laser melting process ; electron beam melting ; composite restoration ; microleakage ; oblique layering technique ; horizontal layering technique ; composite ; fluorescence ; de-bonding ; residuals ; enamel damage ; orthodontics ; radiolucent sign ; OPG ; CBCT ; third molar ; oral surgery ; periapical sign ; biofilm ; bone healing capacity ; infected gutta-percha ; rat calvarium ; zirconia ; airborne particle abrasion ; femtosecond laser ; flexural strength ; surface roughness ; bond strength ; brackets ; dry ; wet and moistened enamel ; adhesion ; calcium phosphate ; radiation-induced center ; hyperfine interaction ; EDNMR ; ESEEM ; ENDOR ; biomaterial ; bone regeneration ; bone substitute ; dental implant ; octacalcium phosphate ; TiN ion plating ; metal allergy ; orthodontic wire ; micro-implants ; success rate ; insertion ; loading ; biocompatibility ; compliance ; dental material ; restorative material ; glass ionomer ; resin-modified glass ionomer ; pH ; acidity ; oral environment ; dental filling ; dental restoration ; apical negative pressure irrigation ; calcium hydroxide removal ; intracanal medicament ; mechanical activation ; ultrasonic activation ; osseoincorporation ; osseointegration ; trabecular metal ; guided tissue regeneration ; barrier membranes ; allergology ; demineralized dentin matrix ; human demineralized dentin matrix ; human ; bone graft ; FT-MIR ; SEM ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Due to their lightweight and high specific strength, Mg-based alloys are considered as substitutes to their heavier counterparts in applications in which corrosion is non-relevant and weight saving is of importance. Furthermore, due to the biocompatibility of Mg, some alloys with controlled corrosion rates are used as degradable implant materials in the medical sector. The typical processing route of Mg parts incorporates a casting step and, subsequently, a thermo–mechanical treatment. In order to achieve the desired macroscopic properties and thus fulfill the service requirements, thorough knowledge of the relationship between the microstructure, the processing steps, and the resulting property profile is necessary. This Special Issue covers in situ and ex situ experimental and computational investigations of the behavior under thermo–mechanical load of Mg-based alloys utilizing modern characterization and simulation techniques. The papers cover investigations on the effect of rare earth additions on the mechanical properties of different Mg alloys, including the effect of long-period stacking-ordered (LPSO) structures, and the experimental and computational investigation of the effect of different processing routes.
    Keywords: magnesium alloys ; long period stacking ordered structures (LPSO) ; synchrotron radiation diffraction ; magnesium alloy ; low-speed extrusion ; microstructure evolution ; mechanical properties ; thermomechanical processing ; calcium addition ; disintegrated melt deposition ; processing map ; formability ; initial texture ; deformation mechanism ; texture evolution ; ductile damage ; GTN model ; magnesium ; in-situ ; deformation mechanisms ; deformation behaviour ; restoration mechanisms ; electron microscopy ; characterisation ; in-situ diffraction ; Mg-LPSO alloys ; neutron diffraction ; EBSD ; dislocation slip ; twinning ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.
    Keywords: infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%–10% of women of reproductive age, to 50% of infertile women. Its etiopathogenesis of endometriosis still remains controversial—immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.This book aims to summarize recent ground-breaking studies that may open new scenarios and change the perspective of the topic, including cutting-edge elements about diagnosis, pharmacologic and surgical treatments, as well as basic/translational science (immunology, cell biology, genetics, and epigenetics) pieces of evidence, to unravel new pathways to follow for the future diagnosis and management of endometriosis, and to improve our current knowledge of its aetiology.
    Keywords: BTG1 ; endometriosis ; human endometrial stromal cells ; endometrium ; uterus ; purinergic signaling ; ATP ; pathogenesis ; genetics ; epigenetics ; immunology ; ion channels ; etiology ; CFTR ; aquaporin ; chloride channels ; biomarker ; angiogenesis ; cytokines ; urinary biomarkers ; genetic polymorphisms ; SNPs ; aetiology ; Mediterranean population ; Sardinian population ; peritoneal fluid ; microenvironment ; precision medicine ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This Special Issue focuses on the current state of pharmacogenomics (PGx) and the extensive translational process, including the identification of functionally important PGx variation; the characterization of PGx haplotypes and metabolizer statuses, their clinical interpretation, clinical decision support, and the incorporation of PGx into clinical care.
    Keywords: pharmacogenomics ; return of results ; genetic counseling ; qualitative ; pharmacogenetics ; implementation ; pharmacogenetics service ; screening ; pre-emptive ; personalized medicine ; precision medicine ; community pharmacy ; pharmacogenomic testing ; genetic privacy ; pharmaco-economics ; polymorphisms ; pharmacogenes ; pharmacogenomic ; machine learning ; adaptation ; human evolution ; US Food and Drug Administration ; clinical actionability ; clinical translation ; chronic kidney disease ; CYP3A5 ; polymorphism ; progression ; pharmacogenomics (PGx) ; pediatrics ; best practice alerts (BPAs) ; electronic health records (EHR) ; genomic indicators ; clinical decision support (CDS) ; phenotype ; genotype ; polypharmacy ; chronic disease ; medication management ; electronic medical record ; artificial intelligence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The direction of fiber orientation plays a crucial role in deciding the mechanical performance of textile structural composites. Unlike conventional composite materials, geometrically oriented textile structures, e.g., woven, knitted, and braided constructions, can be designed and developed for load bearing in a particular direction. Their properties can be enhanced by modifying the geometry and material composition. One major challenge in producing textile structural composites with superior mechanical properties at a reasonably lower price is cost effective prepreg. Composites constructed from reinforcement having a well-defined geometry perform better than randomly oriented fibers at a reasonable cost. Their flex fatigue is superior to conventional preforms in specific applications. This Special Issue invites research as well as review articles dealing with different types of (2D, 3D, multiaxial) woven, knitted, and braided structures for load bearing structural composite applications. Use of industrial multifilament yarns of pure and hybrid composition in textile geometrical reinforcement structures can also be included. The methods of impregnation of such structures by thermoplastic and thermoset resins should be described. The superior performance in such structural composites must be highlighted. Methods of characterizing woven, knitted, and braided textile reinforced composites is the focus of this issue. Current and future applications of advanced textile structural composites can be summarized in the submitted articles. Theoretical (computational, numerical simulation etc.) as well as experimental work can be submitted with sufficient scientific innovation.
    Keywords: hybrid composite ; polyester waste fiber ; olive root fiber ; coir pith filler ; building materials ; mixture design analysis ; recycled cotton ; glass ; hollow knitted composite ; compression ; flexural modulus ; impact energy ; quasi-static test ; cyclic fatigue ; wavy-lap bond ; natural cotton fabric ; polymer composite ; mechanical properties ; service life ; safety ; SEM ; pressure-actuated cellular structure ; shape morphing ; compliant mechanism ; anisotropic flexure hinges ; textile-reinforced polymer composite ; integrally woven structure ; resin ; glass cloth ; substrate ; glass transition temperature ; surface finish ; pad cratering ; thermal resistance ; textile structural composite ; 3D weaving ; hollow structure ; spacer fabric ; woven honeycomb ; sandwich ; waste cotton ; impact ; flexural rigidity ; hybrid woven reinforcement ; preforming ; carbon-Kevlar ; epoxy resin ; add-on (%) ; amount of hardener (%) ; curing temperature ; curing time ; molding pressure ; fiber composites ; FRP ; architecture ; architectured materials ; hysteresis ; auxetic ; non-Newtonian fluids ; low-velocity impact ; personal protection ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The researchers involved in this reprint will continue their studies to improve the existent dental biomaterials in order to achieve optimal dental treatment with biocompatible, bioactive, and stable properties. As the Guest Editors, we sincerely value and thank the reviewers for their insightful comments and the support of the team at Bioengineering. Finally, we express our gratitude to all contributing authors for their valuable research. Altogether, the 16 research papers/reviews in this Special Issue entitled "Recent Advances in Biomaterials and Dental Disease" reflect the importance of in vitro and in vivo studies for improving the efficacy of using biomaterials in dental treatment.
    Keywords: adhesion ; bonding ; dental porcelain ; glass ceramics ; orthodontic bracket ; shear strength ; aligner ; cytotoxicity ; estrogenicity ; invisalign ; monomer ; retainer ; 3D resin ; endodontic sealer ; polyphenols ; resveratrol ; pyrogallol ; biological activity ; piezoelectric surgery ; endodonticsurgery ; crack formation ; ultrasonic tip ; retropreparation ; antibacterial effect ; dental impressions ; disinfectant agents ; disinfection ; oral bacteria ; implant periapical lesion ; implant failure ; peri-implantitis ; endodontic surgery ; complication ; retreatment procedure ; filling materials removal ; revision system ; sonic activation ; oval-shaped canal ; decontamination ; lithium disilicate ; resin ; saliva ; shear bond strength ; crowns ; fixed prosthodontics ; resin composite ; survival ; bond strength ; contact angle ; dentin ; desensitizers ; resin cements ; 3D printing ; digital light processing ; interim crown ; in vivo study ; wear ; endodontists ; general practicing dentists ; root canal treatment ; quality ; undergraduate students ; traumatic dental injury ; tooth fracture ; adhesive reattachment ; pulp ; regeneration ; revitalization ; transplant ; root ; maxillary premolars ; upper premolars ; canal ; root canal anomalies ; anatomical variations ; root morphology ; coneless ; MEA technique ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.
    Keywords: R5-920 ; screening ; MoCA ; neurodegeneration ; accuracy ; frontotemporal dementia ; cognitive assessment ; Free-Cog ; molecular imaging ; Alzheimer’s ; standardised mini-mental state examination ; decision tree ; differential diagnosis depression vs. MCI/dementia ; computerized cognitive assessment ; quantification ; Alzheimer’s disease ; functional cognitive disorder ; diagnosis ; Triple Test ; diagnostic imaging ; neurocognitive disorder ; feasibility ; TYM-MCI ; amyloid ; cerebrospinal fluid ; dementia ; precision medicine ; Mini-Addenbrooke’s Cognitive Examination ; memory ; depression in old age ; quick mild cognitive impairment screen ; cognition ; nuclear medicine ; TYM ; Rapid Cognitive Screen ; 18F-FDG ; functional neurological disorder cognition ; stroke ; sensitivity and specificity ; Codex ; mortality ; mild cognitive impairment ; cognitive screening instruments ; cognitive impairment ; aging ; SKT (Syndrom-Kurztest) ; PET ; executive function ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes.
    Keywords: statin ; myocardial infarction ; renal function ; coronary CT angiography ; subtraction ; fractional flow reserve ; coronary artery disease ; Agatston score ; uric acid ; endothelial function ; ischemic heart disease ; ischemia with no obstructive coronary artery disease ; angioplasty ; drug-eluting stents ; non-ST-elevation myocardial infarction ; multivessel disease ; acute coronary syndrome ; chronic coronary syndrome ; xanthine oxidoreductase ; coronary artery spasm ; gender differences ; vasospastic angina ; microvascular spasm ; microvascular vasodilatory function ; high coronary thrombus burden ; tissue plasminogen activator ; catheter-directed thrombolysis ; olmesartan ; amlodipine ; rosuvastatin ; single pill combination ; phase III clinical trial ; computed tomography ; computed tomography perfusion ; myocardial perfusion abnormality ; aspirin ; clopidogrel ; prasugrel ; P2Y12 inhibitor ; bleeding ; nitrate ; vasodilator ; biomarker ; mortality ; risk-score model ; n/a ; NGAL ; contrast-induced acute kidney injury ; percutaneous coronary intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 80
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: There has been significant growth in branches of industry directly related to new materials, such as metals, polymers, and composite materials. Considering the increase in material costs, it has become exceedingly important to produce lightweight constructions through the use of certified materials with appropriate mechanical properties. Many composite materials, especially in building engineering, are characterized by the use of waste materials, allowing them to meet environmental demands and often also positively affecting the performance (as well as mechanical) properties of the whole construction. A similar phenomenon has been noticed in polymers and metals, with the “ecologically friendly” factor having increasing influence in such materials. The main aim of our Special Issue was to gather novel research results concerning different materials available for all important industries—building engineering, the heavy industry, automotive, aerospace, and medicine. Such a general title has been proposed to also include different manufacturing technologies using various materials—conventional (milling, casting, forming, and turning) and novel (hybrid and additive manufacturing).
    Keywords: additive manufacturing ; powder bed fusion ; 316L stainless steel ; ultrasonic atomization ; gas atomization ; three-point bending ; polyamide-based composites ; fused filament fabrication ; concrete additives ; concrete fibers ; concrete strength tests ; threshold effect ; flake graphene ; graphene oxide ; reduced graphene oxide ; lubricants ; grease ; fatigue life prediction ; CuZn37 brass ; machine learning ; IPCs ; ceramic preform ; ceramic–elastomer composite ; silane coupling agent ; hot isostatic pressing (HIP) ; wettability ; mechanical properties ; mechanical engineering ; laser powder bed fusion ; 21 NiCrMo2 steel ; process parameters ; post-heat treatment ; torsional strength ; cellular structures ; 20MnCr5 Steel ; cement–glass composite bricks ; digital image correlation analysis ; material extrusion ; PET-G ; waste disposal ; hybrid additive manufacturing ; lattice structures ; hot isostatic pressing ; fatigue behaviour ; polymer–straw boards ; thermoplastic polymers ; annual plants ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. This Special Issue gathers eight research articles covering a broad range of strategies on how to combat spinal cord injuries, from searching for therapeutic target molecules, tackling inflammatory reactions, utilizing cell therapy or cell-based products, combined strategies for axonal plasticity assessment, and prevention of post-surgical epidural adhesions. Moreover, four reviews cover recent findings about the role of stress-activated protein kinases in SCI; progress in stem cell therapies; the mechanisms and benefits of activity-based physical rehabilitation therapies with adjuvant testosterone; and, finally, translational regenerative therapies for chronic spinal cord injury.
    Keywords: R5-920 ; RM1-950 ; spinal cord injury ; neuroinflammation ; cell therapy ; transcriptomics ; cytokines ; hydrogels ; p38. ; neuronal regeneration ; extracellular matrix ; epidural adhesions ; neuroplasticity ; bic Book Industry Communication::M Medicine
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: In higher mammals, including primates and carnivores, the asymmetrical aspects of brain morphology and function have been shown to be species-related, sex-related, and subject to individual diversity, and are associated with cognition, emotion, language, preference of hand/paw use, and numerous other aspects. Disturbance of the brain lateralization is involved in human neurodevelopmental disorders with cognitive impairments, social deficits, and/or specific language impairments. Asymmetric development may be essential to the evolution of the brain in acquiring higher and/or more diverse functions. The purpose of this Special Issue on “Brain Asymmetry in Evolution” is to highlight morphological and functional lateralization of the brain in various species of mammals toward understanding the evolution of the brain.
    Keywords: oxyhemoglobin level ; state anxiety ; task performance ; heart rate ; human ; asymmetry ; sex difference ; MRI ; volumetry ; cerebellum ; ferret ; lateralization ; side bias ; fish ; methodological artefacts ; symmetry ; non-human primate ; Old World monkey ; evolution ; evolutionary expansion ; gyrification ; structural asymmetry ; language laterality ; topological data analysis ; persistent homology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: Ultrasonic waves are nowadays used for multiple purposes including both low-intensity/high frequency and high-intensity/low-frequency ultrasound. Low-intensity ultrasound transmits energy through the medium in order to obtain information about the medium or to convey information through the medium. It is successfully used in non-destructive inspection, ultrasonic dynamic analysis, ultrasonic rheology, ultrasonic spectroscopy of materials, process monitoring, applications in civil engineering, aerospace and geological materials and structures, and in the characterization of biological media. Nowadays, it is an essential tool for assessing metals, plastics, aerospace composites, wood, concrete, and cement. High-intensity ultrasound deliberately affects the propagation medium through the high local temperatures and pressures generated. It is used in industrial processes such as welding, cleaning, emulsification, atomization, etc.; chemical reactions and reactor induced by ultrasonic waves; synthesis of organic and inorganic materials; microstructural effects; heat generation; accelerated material characterization by ultrasonic fatigue testing; food processing; and environmental protection. This book collects eleven papers, one review, and ten research papers with the aim to present recent advances in ultrasonic wave propagation applied for the characterization or the processing of materials. Both fundamental science and applications of ultrasound in the field of material characterization and material processing have been gathered.
    Keywords: ultrasonic lens ; axicon lens ; focused ultrasound ; transcranial ultrasound ; non-destructive inspection ; damage identification ; topology optimization ; ultrasonic wave propagation ; ultrasonic visualization ; L-shaped ultrasonic wave guide rod ; ultrasonic bending vibration ; 2A14 aluminum alloy ; solidification structure ; composition segregation ; 1060 aluminum alloy ; twin-roll casting ; microstructure ; mechanical properties ; concrete ; mesostructure ; Lamb wave ; heterogeneity ; Monte Carlo method ; SHM ; ultrasound ; time of flight ; reinforcement ; resin transfer molding (RTM) ; permeability ; liquid composite molding ; material characterization ; composite manufacturing ; liquid penetration ; ultrasound transmission ; capillary penetration ; porous sheets ; bulk metallic glass ; ultrasonic assisted turning ; finite element analysis ; cutting force ; guided waves ; setting time ; mortar and concrete ; early age ; thermoplastic composites ; ultrasonic joints ; resistance heating ; elastography ; viscoelastic properties ; creep ; stress relaxation ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Because of the increasing pressure on both food safety and packaging/food waste, the topic is important both for academics, applied research, industry and also for environment protection. Different materials, such as glass, metals, paper and paperboards, and non-degradable and degradable polymers, with versatile properties, are attractive for potential uses in food packaging. Food packaging is the largest area of application within the food sector. Only the nanotechnology-enabled products in the food sector account for ~50% of the market value, with and the annual growth rate is 11.65%. Technological developments are also of great interest. In the food sector, nanotechnology is involved in packaging materials with extremely high gas barriers, antimicrobial properties, and also in nanoencapsulants for the delivery of nutrients, flavors, or aromas, antimicrobial, and antioxidant compounds. Applications of materials, including nanomaterials in packaging and food safety, are in forms of: edible films, polymer nanocomposites, as high barrier packaging materials, nanocoatings, surface biocides, silver nanoparticles as potent antimicrobial agents, nutrition and neutraceuticals, active/bioactive packaging, intelligent packaging, nanosensors and nanomaterial-based assays for the detection of food relevant analytes (gasses, small organic molecules and food-borne pathogens) and bioplastics.
    Keywords: TA1-2040 ; T1-995 ; TA401-492 ; alginate film ; antibacterial activity ; chitosan ; simulation ; vegetable oil ; degradation ; antibacterial ; montmorillonite nanoclay ; nanocomposites ; nanocoating ; smart nanomaterials ; tensile test ; fire ; rosehip seed oil ; biomaterials ; essential oil ; nanocoatings ; fused deposition modelling (FDM) ; antioxidant ; pectin film ; mechanical properties ; risk analysis ; personalized design ; powdered rosemary ethanolic extract ; barrier properties ; combustion ; cold-press oil ; polymer ; antimicrobial ; thiazolidine-4-one scaffold ; customization ; poly(lactic) acid ; graphene ; edible film ; carbon nanotubes ; electrospinning ; packaging design ; computer aid design (CAD) ; food packaging ; thermoforming ; reverse engineering ; technology ; product design ; risks ; polymeric systems ; bioactive food packaging ; poly(lactic acid) ; 3D printing ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue provides an overview of pediatric integrative medicine, an emerging field that blends conventional and evidence based complementary therapies with an emphasis on preventive health and wellbeing.
    Keywords: R5-920 ; RJ1-570 ; cognitive behavioral therapy ; pain rehabilitation ; n/a ; education ; pediatric integrative medicine ; musical therapy ; mind-body ; non-pharmacological therapy ; guided imagery ; complementary ; infant ; pediatric ; multidisciplinary pain management strategies ; integrative medicine ; qualitative ; advocacy ; clinic model ; massage ; obesity ; Kneipp ; multidisciplinary ; adolescents ; mindfulness ; sucrose ; program development ; vision ; complementary therapies ; residents ; art therapy ; pastoral care ; academic medicine ; kindergarten ; yoga ; assessment of withdrawal ; clinical practice ; pediatric integrative nursing ; eHealth ; mindful eating ; opioid reduction therapy ; burnout ; resilience ; pediatric blood and marrow transplant ; preventive lifestyle behaviors ; biofeedback ; pain ; migraine ; Integrative therapies ; creative arts therapy ; weaning of opioids ; implementation ; yoga therapy ; mindfulness-based stress reduction ; withdrawal ; music therapy ; hypnosis ; acupuncture ; premature ; chronic illness ; meditation ; pediatrics ; skin-to-skin contact ; opioid therapy ; self-regulation ; headache ; PIMR ; breastfeeding ; bic Book Industry Communication::M Medicine
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book is the result of a Special Issue published in Applied Sciences, entitled “New Trends in Recycled Aggregate Concrete"". It identifies emerging research areas within the field of recycled aggregate concrete and contributes to the increased use of this eco-efficient material.Its contents are organised in the following sections: Upscaling the use of recycled aggregate concrete in structural design; Large scale applications of recycled aggregate concrete; Long-term behaviour of recycled aggregate concrete; Performance of recycled aggregate concrete in very aggressive environments; Reliability of recycled aggregate concrete structures; Life cycle assessment of recycled aggregate concrete; New applications of recycled aggregate concrete.
    Keywords: TA1-2040 ; T1-995 ; crushing ; heavyweight waste glass ; n/a ; recycled aggregate quality ; seismic load ; microstructure ; construction waste ; permeability ; bond strength ; seismic performance ; aggregate interlock mechanism ; recycled concrete aggregates ; compressive strength ; crumb rubber ; cellular concrete ; model ; cyclic load ; recycled aggregate ; crushed glass ; models ; recycled aggregate concrete ; reactive power concrete ; recycled aggregate concrete (RAC) ; energy absorbing ; creep ; elevated temperature ; fiber-reinforced concrete ; size effect ; recycled concrete aggregate ; geological nature of aggregates ; mechanical properties ; recycled concrete ; artificial neural networks ; recycled aggregates ; steel fibre ; quality of aggregates ; aggregates ; foam stability ; ceramic foam ; durable characteristics ; nylon fiber ; concrete ; mechanical characteristics ; strain rate ; steel reinforced recycled aggregate concrete (SRRAC) ; dynamic mechanical property ; concrete sludge fines ; water absorption ; columns ; environmental impact ; blast-furnace slag ; input variable ; tensile splitting strength ; aggregate ; returned concrete ; reinforced concrete member ; variable sensitivity ; soil stabilization ; numerical analysis ; shear behavior ; fly-ash ; modulus ; life cycle assessment ; foam structure ; silica fume ; recycling ; recycled coarse aggregate concrete ; ready-mixed concrete ; foam concrete ; flexural behavior ; mixture proportioning ; aggregate characteristic ; residual properties ; CT ; reinforced concrete ; shrinkage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
    Keywords: idiopathic scoliosis ; health-related quality of life ; cultural adaptation ; Italian Spine Youth Quality of Life Questionnaire ; systematic review ; meta-analysis ; adolescent idiopathic scoliosis ; brace therapy ; brace concepts ; rigid brace ; night time brace ; ring apophysis ; maturation ; ossification ; fusion ; scoliosis ; nighttime orthotic treatment ; surgery ; quality of life ; paraspinal muscles ; cross-sectional area ; posterior approach ; computed tomography ; Italian spine youth quality of life questionnaire ; SRS-22 ; 22q11.2 deletion syndrome ; human model ; neuromuscular scoliosis ; radiography ; MRI ; curve morphology ; intraspinal anomaly ; body height ; pulmonary function test ; Cobb angle ; iTRAQ ; α-actin ; progressive ; differentially expressed proteins ; bracing ; physiotherapeutic scoliosis-specific exercise ; physical activity ; adherence ; spinal appearance ; shared decision-making ; personalised approach ; sclerostin ; osteocytes ; β-catenin ; Wnt signaling pathway ; scoliometer ; truncal asymmetry ; lateral spinal profile ; surface topography ; aetiology ; spinal deformities ; pathobiomechanics ; follow-up study ; Rett syndrome ; motor skills ; telerehabilitation ; physical therapy modalities ; home exercise program ; neurodynamic functions ; assessment ; pain ; treatment ; early onset scoliosis ; non-operative treatment ; body posture ; sports activity ; corrective exercises ; digital photography ; n/a ; bic Book Industry Communication::M Medicine
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered.
    Keywords: as low as reasonably achievable ; computed tomography ; convolutional neural network ; deep learning ; dose reduction ; generative adversarial network ; image processing ; machine learning ; medical imaging ; noise ; contrast-enhanced ultrasound ; head ultrasound ; brain death ; infants ; ancillary test ; child ; paediatric ; infant ; adolescent ; chest X-ray ; CXR ; chest radiography ; COVID-19 ; SARS-CoV-2 ; coronavirus ; biliary atresia ; ultrasonography ; diagnostic accuracy ; intraoperative cholangiography (IOC) ; diagnostic performance ; elastography ; three-dimensional printing ; congenital heart disease ; children ; model ; personalized medicine ; application ; confusion matrix ; disease identification ; image interpretation ; pneumonia ; artificial intelligence (AI) ; deep learning (DL) ; paediatric pneumonia ; chest radiograph ; computer-aided detection (CAD) ; cumulative ; radiation dose ; acute tonsillitis ; shear wave elastography ; stiffness ; pediatric ; magnetic resonance imaging ; infection ; neck ; emergency medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: A collection of articles published under the guidance of Assoc. Prof. Ph.D. Andrei Victor SANDU in the Special Issue "Obtaining and Characterization of New Materials, Volume II". The published articles under this Special Issue represent an excellent collection of research and review articles with cutting-edge results that promote sustainable development in the field of material engineering.
    Keywords: sheep wool thermal-insulating mattresses ; air quality ; water vapor permeability ; formaldehyde ; road concrete ; porosity ; (NMR) relaxometry ; freeze–thaw ; blast furnace slag ; bismuth ; intermetallic compound ; IMC thickness ; mechanical properties ; isothermal annealing ; geopolymer ; fly ash ; GGBFS ; compressive strength ; soil stabilization ; flowable composite resin ; hydrochloric acid ; surface roughness ; toothbrush ; thermal insulation ; recycling ; polyethylene terephthalate (PET) ; polyester (PES) ; natural fibres ; sheep wool ; chia seed oil ; fatty acids composition ; epoxidized vegetable oil ; epoxy equivalent weight ; shear thickening fluids ; aging ; lightfastness ; product degradation ; rigid pavement ; fly ash based geopolymer ; acid resistance ; selective laser sintering ; spread the powder quality ; parameter optimization ; DEM ; RSM ; NSGA-II ; 9K medium ; bioleaching ; Thiobacillus ferrooxidans ; pollution indices ; ecological risk ; polyoxyethylene alkyether sulphate foam ; blended geopolymer foam ; high temperature ; pre-foaming method ; hydroxyapatite ; lysine ; inorganic–organic composite ; glassy carbon electrode ; electrode coating ; electrochemical analysis ; Nile blue A ; multi-beam box girder bridge ; ESP strengthening ; field test ; load lateral transferring performance ; structural stiffness ; densified wood ; ammonia ; Brinell hardness ; Paulownia ; hornbeam ; geopolymers ; laser sintering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.
    Keywords: metronomic ; oral cancer ; oral squamous cell carcinoma ; metronomic chemotherapy ; metastatic castration-resistant prostate cancer ; cyclophosphamide ; side effects ; pediatric tumors ; etoposide ; valproic acid ; prostate cancer ; CRPC ; castration ; capecitabine ; paclitaxel ; immunomodulation ; angiogenesis ; microbiome ; breast cancer ; safety ; preclinical studies ; clinical studies ; pharmacokinetic studies ; biomarkers ; chemo-free ; DLBCL ; diffuse-large-b-cell-lymphoma ; elderly ; frail ; comprehensive geriatric assessment ; chemo-endocrine therapy ; FulVEC ; pediatric oncology ; brain tumors ; pharmacology ; medulloblastoma ; ATRT ; immunotherapy ; lymphoma ; vinorelbine ; checkpoint inhibitors ; bic Book Industry Communication::M Medicine
    Language: English
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.
    Keywords: cross-sectional study ; dry eye disease ; systemic comorbidity ; graves’ ophthalmopathy ; inflammation ; meibomian glands ; morphological changes ; meibomian gland dysfunction ; ocular surface disease ; dry eye symptoms ; questionnaire ; Bangladesh ; global health ; epidemiology ; aqueous-deficient dry eye ; meibomian gland ; intense pulsed light ; severe keratitis ; hyaluronan ; hylan A ; multicenter ; randomized trial ; gabapentin ; dry eye ; neuropathic pain ; diabetes ; neuropathic keratopathy ; neuropathy ; nerve growth ; neurotrophic ; Houttuynia ; ultrasonic atomization ; meibography ; meiboscore ; TRPM8 agonist ; cryosim-3 ; fatty acids ; vitamin D ; brief-type self-administered diet history questionnaire ; Japanese ; bic Book Industry Communication::M Medicine
    Language: English
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-24
    Description: Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.
    Keywords: saffron ; affron® ; depression ; anxiety ; antioxidant ; crocins ; glucose ; β-pancreatic cells ; insulin ; pck1 ; neuroprotective activity ; P2X7 receptor ; fraction ; flumazenil ; rat ; Crocus sativus ; cancer ; anticancer activity ; chemoprevention ; clinical trials ; patents ; anesthetic ketamine ; memory ; Crocus sativus L. ; schizophrenia ; crocetin ; pubertal testis ; X-rays ; radiotherapy ; fertility preservation ; SIRT1 ; HuR ; oxidative stress ; autophagy ; crocin ; picrocrocin ; safranal ; dietary supplement ; nutraceutical ; Crocus sativus L. (Iridaceae) ; reversed-phase UPLC ; metabolomics ; HR MS ; inflammatory bowel disease ; gut microbiota ; colitis ; cytokines ; colorectal cancer ; HCT116 ; MLH1 ; MSH3 ; DNA damage and repair ; apoptosis ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.
    Keywords: R5-920 ; alginate ; chitosan ; gold nanoparticles ; biochemical mechanism ; cancer imaging ; lignin ; thioredoxin reductase ; antimiR ; nanoparticles ; surface enhanced Raman scattering ; biomedical applications ; protein ; multidrug resistant (MDR) microorganisms ; nano-bio interaction ; curcumin ; autophagy ; MIC ; nanoparticle ; biocompatible ; gene delivery ; self-assembly ; glioblastoma ; dual functional imaging nanoprobe ; SERS ; antibiotics ; biogenic nanoparticles ; Hg2+ ions detection ; antimicrobial ; histamine ; layer-by-layer ; dihydroartemisinin ; computational electromagnetism ; photolysis ; Ag-film ; chitosan nanoparticles ; UiO-66 ; plasma liquid Interactions ; anticancer ; MBC ; nanophotonics ; targeted nanoparticles ; near-infrared ; hybrid Fe-Si nanoparticles ; FTIR ; thermoplastic polymer ; synergism ; prognosis ; medical devices ; silver nanoparticles ; glioma ; plasma ; iron oxide superparamagnetic nanoparticles ; oxidative stress ; mycosynthesis ; membrane integrity ; drug delivery ; nanocomposites ; finite element method ; cell labeling ; in vivo application ; non-thermal plasma ; nanocellulose ; biocompatibility ; liposomes ; nanocarriers ; upconversion nanoparticles ; Candida glabrata ; nanomaterials ; middle ear prosthesis ; short-wave infrared ; cytoreduction surgery ; fibril ; nanostars ; fluorescent nanoparticle ; density functional theory calculations ; cross-link ; mitoxantrone ; heat ; SERS sensor ; Caco2 cells ; apoptosis ; surface-enhanced Raman spectroscopy (SERS) ; MFC ; magnetic nanoparticles ; antibiotic resistance ; laser pyrolysis ; cytotoxicity ; core-shell nanoparticles ; enzyme ; extracellular ; nanomaterial synthesis ; cancer cell targeting ; nanodiamond ; breast cancer ; metal-enhanced fluorescence (MEF) ; PEG ; radiation ; trans-resveratrol derivative ; radiosensitization ; cancer ; surface-enhanced Raman scattering (SERS) ; TEM ; bic Book Industry Communication::M Medicine
    Language: English
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: In the past few years, knowledge about glaucoma diagnosis and follow up has evolved dramatically through advances in intraocular pressure (IOP) measurement, corneal biomechanics, structural and functional assessment of the ocular surface, anterior chamber, retina, optic nerve and intracranial visual pathways, as well as the advent of artificial intelligence. In addition, the development of new modalities of IOP-lowering and non-IOP-lowering drugs, alternative deliveries, refined laser technologies, and minimally invasive glaucoma surgery (MIGS) techniques with different implants have widened the therapeutic possibilities for treating this disease. Finally, current insights into risk factors and quality of life in relation to glaucomatous impairment are emerging. The purpose of this Special Issue is to present the latest exciting clinical developments that are taking place in the field of glaucoma.
    Keywords: ripasudil ; suture trabeculotomy ab interno ; Schlemm’s canal incision ; aqueous outflow ; open-angle glaucoma ; glaucoma ; inflammation ; oxidative stress ; phenotype ; polymorphism ; susceptibility ; intraocular pressure ; ocular inflammation ; cornea biomechanics ; Corvis® ST ; subclinical keratoconus ; ocular hypertension ; tears ; miRNAs ; next generation sequencing ; biomarkers ; genes ; signaling pathways ; apoptosis ; neurodegeneration ; glaucoma suspect ; lamina cribrosa ; optical coherence tomography angiography ; peripapillary vessel density ; OCTA ; vessel density ; disc ; peripapillary ; NTG ; BRVO ; corneal hysteresis ; corneal biomechanics ; ocular biomarkers ; deep learning ; perimetry ; optic nerve ; obesity ; risk factor ; young adults ; multifocal visual evoked potentials ; mfVEP ; physical exercise ; sport ; acrobatic gymnastics ; baseline intraocular pressure ; central corneal thickness ; ocular health ; tumbling skills ; hand balance ; cytokines ; BDNF ; VEGF ; fractalkine ; microglia ; saffron ; crocin ; retinal glial cells ; microperimetry ; OCT ; macula ; structure ; function ; correlation ; retina ; inner ; outer ; macular segmentation ; optical coherence tomography-angiography ; vascular density ; blood flow ; biomarker ; myopia ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint covers the latest developments in the field of eco-polymeric materials and natural polymer processing and utilization, highlighting cutting-edge research focusing on the processing of advanced polymers and their composites. It demonstrates that the field of eco-polymeric materials and natural polymers is still gaining increased attention. Innovative approaches as well as advanced applications of eco-polymeric materials and natural polymers in different fields, such as energy, environment, biomedical, biomaterial, and engineering, are reported in this reprint.
    Keywords: outdoor wood mats-based engineering composite ; wood-degrading fungi ; decay resistance ; durability ; nanohydrogels ; citral ; sustained-release ; mechanism ; bamboo ; anti-mould ; rosin modification ; round bamboo culm ; visual characteristics ; eye tracking ; surfactant ; urea-formaldehyde resin ; laminated bamboo veneer ; gluability ; wood–plastic composites ; heat transfer modeling ; sweet sorghum ; high-density polyethylene ; hot-pressing ; fibrovascular bundle ; salacca frond ; modified orientation board ; citric acid ; Aquilaria crassna wood ; natural rubber ; antifungal ; lignin ; proteins ; compression performance ; load–displacement curves ; digital image correlation (DIC) ; failure mode ; coupling agent ; interfacial bonding ; oriented strand–thermoplastic composites ; wood veneer–thermoplastic composites ; cross-laminated timber ; stability coefficient ; axial compression ; timber structures ; slenderness ratio ; Chinese pine wood ; pine needles ; bamboo culms ; bamboo leaves ; industrial hemp hurd ; CMC ; DS ; mechanical properties ; TG ; XRD ; FTIR ; chitosan ; tartaric acid ; nanocrystal ; self-assembly ; evaporation ; dehydration of crystallization ; biopolymers ; sustainability ; emergy accounting ; polyhydoxyalkanoates ; slaughterhouse residues ; poly(lactic acid) ; impact modifier ; polymer blends ; properties ; multilayered bamboo fiber ; topochemistry ; microscopic imaging ; gradient micromechanics ; core–shell structure ; hydrogel ; double load ; response surface ; acidic treatment ; colour ; mould-resistant ; starch ; Phyllostachys pubescens ; fibre ; lignification ; micro-morphological regions of cell wall ; syringyl lignin ; guaiacyl lignin ; visible-light spectrophotometry ; electrochemical method ; moisture content ; shrinkage strain ; wood water loss ; konjac glucomannan ; oxidized hyaluronic acid ; hydrogels ; tung oil ; thermal treatment ; color ; cellulose fibers ; adsorption ; Cr(VI) ; sulfhydryl-modified ; water resistance ; bamboo scrimber composite ; bonding interface ; polymer soil consolidation agent ; preparation conditions ; consolidated adhesive film ; compressive strength ; seedling transplanting ; chemical change ; thermal property ; delignification ; pyrolysis ; bamboo microstructure ; shear performance ; test methods ; moso bamboo ; fracture behavior ; shearing characteristics ; transparent bamboo ; optical properties ; functionalization and application ; glycerin ; sodium alginate ; tensile strength ; elongation at break ; poplar ; cell walls ; cross-linking modification ; wood properties ; egg white hydrogel ; dual cross-linking ; metal ions ; secondary structure ; biocompatibility ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: A full awareness of the role played by a healthy diet, as part of a healthy lifestyle, in countering or slowing-down chronic and degenerative diseases has strongly increased the interest in food bioactives and the return of ancient foods that are nowadays considered functional. In fact, these dietary substances, to which nutraceutical attributes are increasingly entrusted, could display disease-preventing effects on animals and humans. In this context, polyphenols, which are widespread and mostly copious in dietary plant sources, have gained a lot of attention thanks to their potential ability to halt or reverse oxidative stress-related diseases. Indeed, food could contain, beyond health-promoting compounds, toxicants which are naturally occurring or process-induced dietary compounds with adverse effects on human health. The presence and abundance of bioactives are strictly related to their food source. Edible plant components largely contain beneficial secondary metabolites, but understanding them fully is still an important challenge as complex biotic and abiotic interactions are involved in their biosynthesis. Analytical methods, which are increasingly powerful, could enhance our knowledge of food bioactives, whereas the deep investigation of their bioactivity and bioavailability could make them particularly useful.
    Keywords: Urtica dioica ; natural products bioactivity ; food bioactives ; nutraceuticals ; cancer therapy ; breast cancer ; Aloe vera ; Aloe vera polysaccharides ; in vitro fermentation ; SCFAs ; antioxidant capacity ; food waste recovery ; grape leaves ; UHPLC-HR-MS/MS analysis ; flavonol glycuronides recovery ; linoleic acid peroxidation products ; hexane ; gastric cells ; metabolomics ; cDNA microarray ; avocado ; LC/MS ; fat-soluble vitamins ; carotenoids ; Cannabis sativa L. ; phenylamides ; lignanamides ; hemp seeds ; high resolution tandem mass spectrometry ; U-87 glioblastoma cells ; cytotoxicity ; Pistacia vera ; antioxidant ; quality ; tocopherol ; FTIR ; discriminant analysis ; pistacia (Pistacia vera) hulls ; anticancer ; bacterial resistance ; efflux pumps ; terpenoids ; thymol ; carvacrol ; Rosmarinus officinalis L. ; fresh young shoots tincture ; polyphenols ; terpenes ; hepatoprotective ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
    Keywords: infliximab ; etanercept ; TNFα inhibitors ; biologics ; biosimilars ; Germany ; policies ; incentives ; uptake ; market dynamics ; biosimilar market ; biosimilar/supply and distribution ; biosimilar sustainability ; Delphi technique ; pricing ; reimbursement ; utilization ; biosimilar ; biological ; information ; education ; communication ; patient ; Europe ; adalimumab ; biosimilarity assessment ; quality attributes (QAs) ; potentially critical quality attributes (pCQAs) ; European public assessment reports (EPARs) ; clinical governance ; Spain ; barriers ; regulatory ; review ; approval ; clinical ; queries ; regulatory science ; budget impact analysis ; savings ; pharmaceutical spending ; cost containment ; reference biological ; competitive market ; Belgium ; trastuzumab ; intravenous ; subcutaneous ; HER2-positive breast cancer ; drug costs ; healthcare costs ; cost simulation ; tender ; procurement ; off-patent ; award criteria ; switching ; interchangeability ; sustainability ; competition ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
    Keywords: Alzheimer disease ; expression quantitative trait loci (eQTL) ; rare variants ; set-based eQTL ; SKAT-O ; pathways ; immune system ; inflammation ; ROSMAP ; ADNI ; complement ; complement receptor 1 ; clusterin ; late-onset Alzheimer’s disease ; genetics ; neuroinflammation ; Alzheimer’s disease ; cytokines and growth factors ; genome-wide association study (GWAS) ; Polygenic Risk Score (PRS)-based analysis ; TOMM40 gene ; RNA transcription ; pseudogene ; mitochondrial dysfunction ; ITIM ; ITAM ; SIGLEC14 ; SIGLEC5 ; copy number variation ; CNV ; GWAS ; long non-coding RNA ; biomarkers ; peripheral system ; amyloid β ; tau ; APOE ; TREM2 ; OMICS ; therapeutics ; pairwise feature correlation ; feature reduction ; machine learning ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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