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  • Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie  (4,704)
  • Cham :Springer International Publishing :  (3,224)
  • München : Oekom-Verl.
  • English  (4,523)
  • German  (3,445)
  • Dutch
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  • 1
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    Akzeptanz von industriellem CCS in Nordrhein-Westfalen : Empfehlungen für Politik und Industrie (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-01-25
    Description: Für die Landesregierung Nordrhein-Westfalen (NRW) ist die industriell genutzte Kohlenstoffabscheidung und -speicherung (engl. industrial carbon capture and storage, kurz iCCS) ein zentraler Baustein für den Übergang zu einer klimaneutralen Industrie bis 2045. Dafür braucht es aber eine breite gesellschaftliche Akzeptanz - zumal Pläne zur CO2-Abscheidung bei Kohlekraftwerken vor über zehn Jahren schon einmal an mangelnder gesellschaftlicher Akzeptanz gescheitert sind. In diesem In Brief haben die Autor*innen die Ergebnisse von zwei durchgeführten Akzeptanzstudien zu iCCS in NRW zusammengefasst und diskutieren, welche Handlungsempfehlungen sich daraus ergeben.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: workingpaper , doc-type:workingPaper
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  • 2
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    Die Akzeptanz von grünem Wasserstoff in Nordrhein-Westfalen : Status quo und Handlungsempfehlungen (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-01-25
    Description: Nordrhein-Westfalen (NRW) ist Heimat energieintensiver Industrien wie der Stahl- und Chemieindustrie. Künftig wird grüner Wasserstoff notwendig sein, damit die Industrie in NRW Klimaneutralität erreichen kann. Die Herausforderungen hierbei sind jedoch vielfältig - auch wenn die Akzeptanz für grünen Wasserstoff sowohl in der Gesellschaft als auch bei unmittelbar beteiligten Akteursgruppen hoch ist. Die Autor*innen fassen in diesem In Brief die Ergebnisse von zwei durchgeführten Akzeptanzstudien zu grünem Wasserstoff in NRW zusammen und diskutieren, welche Handlungsempfehlungen sich daraus ergeben.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 3
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    Politische Instrumente zur Gewährleistung der Nachhaltigkeit von Wasserstoffimporten : eine Kurzstudie im Auftrag von Brot für die Welt und der Heinrich-Böll-Stiftung (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-04-02
    Description: Für Deutschland und viele Industrieländer weltweit wird der Import von grünem Wasserstoff ein zentraler Baustein auf dem Weg zur Klimaneutralität sein. Dabei muss einerseits gewährleistet sein, dass grüner Wasserstoff auch wirklich "grün" im Sinne von klimaneutral ist. Zugleich gibt es immer mehr Forderungen, dass auch andere Nachhaltigkeitskriterien - soziale, ökonomische und ökologische - bei der Produktion und dem Transport von Wasserstoff eingehalten werden. Der politisch getriebene Aufbau einer globalen Wasserstoffwirtschaft bietet von Anfang an die Möglichkeit, diesen Sektor in Einklang mit den bestehenden politischen Zielen zu bringen. Dazu zählen beispielsweise die Pariser Klimaziele oder die Agenda 2030. Die Industrienation Deutschland, die auch in Zukunft auf Energieimporte angewiesen sein wird, kann hier als führende Industrienation als Vorreiter Einfluss nehmen. Damit kann nicht nur sichergestellt werden, dass der nach Deutschland importierte Wasserstoff "grün und nachhaltig" ist, sondern auch die Nachhaltigkeit des globalen Wasserstoffmarktes insgesamt beeinflusst werden. Diese Kurzstudie untersucht, welche bereits existierenden Politikinstrumente geeignet sind, Nachhaltigkeitskriterien für Wasserstoffimporte zu verankern und im Zusammenspiel den Weg zu einem nachhaltigen globalen Wasserstoffmarkt zu unterstützen. Dabei werden ausschließlich Nachhaltigkeitsziele und -kriterien jenseits der Klimawirkung von Wasserstoff analysiert. Es ist unbestritten, dass das zentrale Ziel der Wasserstoffwirtschaft die Reduktion von Treibhausgasen bis hin zur Klimaneutralität ist, was bereits in einer Vielzahl von Studien und Stellungnahmen diskutiert wurde. Daher wird in dieser Studie von der Klimaneutralität des grünen Wasserstoffs ausgegangen, um den Fokus auf die anderen wesentlichen Nachhaltigkeitsaspekte zu lenken, die für den Import von grünem und nachhaltigen Wasserstoff aus dem Globalen Süden von entscheidender Bedeutung sind.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: report , doc-type:report
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  • 4
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    Pathways towards a green economy in Egypt : analyzing decarbonization and resource efficiency pathways along value chains to support green private sector development in Egypt (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-04-08
    Description: In light of Egypt's transition to a green economy, this report focuses on reducing greenhouse gas (GHG) emissions and increasing resource efficiency along three different value chains in which small and medium-sized enterprises (SMEs) play a crucial role. In order to support SMEs in Egypt to take advantage of implementing greening options along value chains, more detailed analyses are needed. Therefore, the aim of this study is to analyse three selected supply chains to identify greening opportunities for SMEs. Against this background, the project report is structured as follows: Chapter 2 introduces the background with an overview over the concept of green economy followed by Egypt's economy and its green economy. This is followed by a presentation of the value chains and an overview of the respective sectors. Chapter 3 describes the research approach, methods and data collection. The following chapters examine the three selected value chains cotton, sugar beet and refrigerators, including environmental hot spots, greening options as well as the experts' evaluation of those greening options. The report concludes with key recommendations in Chapter 7.
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 5
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    Roadmaps towards a climate neutral petrochemical production system : comparative analysis for Germany and Japan (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-04-10
    Description: In order to limit global warming and fulfill their contributions to the Paris agreement, both Germany and Japan have set targets for climate neutrality towards the middle of the century. Reaching these goals will imply transformation of all sectors of society to avoid all fossil greenhouse gas emissions, heavy industry not the least. The focus of this study is the transformation of the petrochemical industry. This sector can become climate neutral but cannot be "decarbonized", as carbon is integral to the chemical structures of the products like polymers and solvents. Reaching climate neutrality thus means that the whole lifecycle of the petrochemical products has to be regarded. Another specific challenge is today's synergetic relation of this industry to fossil transport fuel production, which cannot be maintained in a climate neutral world. The two countries interestingly share a similar industrial structure overall, and the chemical and petrochemical industry is one of the major industries in both countries. The countries' respective chemical industries are the third and fourth largest in the world in terms of sales, but at the same time, these industries represent just over 5% of the respective countries' greenhouse gas emissions. However, these scope 1 emissions of the chemical industry itself are far less relevant than the end-of-life emissions of their products, which belong to scope 3 and are thus not counted under the chemical industry in the country greenhouse gas balances. To mediate these emissions, there is a need to set the direction, draw out paths and investigate possible alternatives for how the petrochemical industry can be become climate neutral. In this report, the existing scenario analyses, energy strategies and roadmaps dealing with this issue in the two countries are compared, as well as the current state of their petrochemical industries. We highlight similarities, differences and identify possible areas of cooperation and exchange in order to find robust paths forward for the transformation of the petrochemical industries.
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 6
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    Reparatur von Klima- und Einzelraumheizgeräten : Kurzstudie zur Relevanz des Reparierbarkeits-Index (R-Score) (2024)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-05-22
    Description: Die Kurzstudie ist eine Entscheidungshilfe, um die potenzielle Einführung eines Reparierbarkeits-Index (R-Score) für Klima- und Einzelraumheizgeräte im Rahmen der Ökodesign-Richtlinie besser bewerten zu können. Das Ziel der Studie ist es, die Relevanz der Reparierbarkeit von diesen Gerätegruppen einschätzen zu können. Für die Ermittlung der Problemrelevanz wurde eine Befragung durchgeführt, sodass Stimmen von herstellenden Firmen und Verbänden, Großhandel, Installateur*innen, Handwerksbetrieben und Reparatureinrichtungen aufgenommen werden konnten. Die Autor*innen sprechen sich grundsätzlich bei beiden Produktgruppen für die Einführung eines Reparierbarkeits-Index aus und weisen darauf hin, dass für diese Produktgruppen die unabhängige Bewertung der Produktlebensdauer ein wichtiger Hebel ist, um die produktbezogenen Umweltauswirkungen zu reduzieren.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: report , doc-type:report
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  • 7
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    The EU as a normative power? : Fighting greenwashing and promoting the integrity of corporate climate action within and outside Article 6 of the Paris Agreement (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-10-02
    Description: As the climate crisis is accelerating and the pressure to act is steadily increasing, many companies are claiming themselves or their products carbon neutral. This is usually achieved by offsetting residual emissions with carbon certificates (carbon offsetting). However, recent revelations about the inadequate quality of carbon credits and legal uncertainties surrounding the use of such offset claims are increasingly raising doubts about this approach. This Wuppertal Report examines how the EU can promote integrity in corporate climate action. Taking into account the new framework of the Paris Agreement, the paper outlines various options for how the EU could push for more integrity and effectively combat greenwashing through the targeted use of Article 6 of the Paris Agreement. In their recommendations, the authors advocate addressing the most serious consequences of ongoing offset practices through increased regulation of offset claims. If a ban on offset claims cannot be implemented, claims requirements and carbon offset regulations should be further specified, for example, by prohibiting any type of double counting of emissions reductions. In addition to tightening the rules for corporate offset claims within Europe, the EU could help partner countries make informed decisions when approving climate change mitigation measures and respective carbon credits. The report also emphasizes the EU's special role in international climate negotiations, where it should advocate for a strong legal framework for climate action under Article 6.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 8
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    Plastic Credits als Instrument zur Annäherung an eine Circular Economy : Einordnung der Nutzung des Marktmechanismus auf Abnehmerseite (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-10-02
    Description: Die verheerenden Mengen an Abfall am Ende des Lebenszyklus von Produkten zu bewältigen, gilt als eine der größten Herausforderungen auf dem Weg zu einer Circular Economy. Die negativen Folgen, die sich aus dem Missmanagement von Kunststoffabfällen aufgrund fehlender oder nicht funktionierender Abfallwirtschaftsstrukturen in weiten Teilen der Erde ergeben, werden zunehmend deutlich. Bei der Circular Economy als elementarer Lösungsansatz sollen Stoffströme geschlossen und Produktlebenszyklen verlängert werden. Ein Instrument zur Annäherung an dieses Modell ist der Handel mit sogenannten Plastic Credits - ein Mittel, um den Ausbau regionaler Infrastrukturen für die Sammlung und das Recycling von Kunststoffabfällen zu finanzieren. Die Abnehmer von Plastic Credits sind die treibende Kraft hinter dem Mechanismus. Es ist weiterführende Forschung notwendig, insbesondere in Bezug auf die Frage, wie Unternehmen das Instrument der Plastic Credits nutzen und in ihre Gesamtstrategie integrieren. Diese Masterarbeit widmet sich der dabei vorgelagerten Frage: Existieren bestimmte Profile bei Unternehmen, die in Plastic Credits investieren, und lassen sich hierbei spezifische Cluster bilden? Im Rahmen der Beantwortung dieser Frage wurden Expert*innen-Interviews mit Hilfe der qualitativen Inhaltsanalyse nach Mayring ausgewertet. Dabei haben sich drei konkrete Unterfragen ergeben, die sich auf die Motivation, Branchenzugehörigkeit und räumliche Verortung der Abnehmer beziehen. Die Ergebnisse zeigen, dass sich die Abnehmer von Plastic Credits bereits umfangreich mit der Kunststoffabfallproblematik und der damit verbundenen Auswirkung auf die Umwelt beschäftigen. Offen bleibt, inwiefern Maßnahmen zur Vermeidung von neuartigem Kunststoff, der Verbesserung der Recyclingfähigkeit der Produkte oder der Einsatz von Rezyklaten in der Herstellung dem Weg der Kompensation vorangestellt werden. In Bezug auf die Branchenzugehörigkeit legen die Ergebnisse nahe, dass vorrangig Unternehmen, die mit einem erschwerten Rezyklate-Einsatz konfrontiert sind, in Plastic Credits investieren. Welche Auswirkungen Maßnahmen wie die Entbürokratisierung der Zulassungsverfahren für neue Recyclingprozesse oder verpflichtende Anteile an recycelten Materialien in bestimmten Produkten auf die Investition in Plastic Credits haben, wird sich in Zukunft zeigen. Die Analyse der räumlichen Verortung gab Aufschluss darüber, dass zurzeit im Wesentlichen Unternehmen aus dem globalen Norden in Plastic Credits investieren - jedoch verbunden mit dem Ziel, eine Finanzierung aus den Projektländern heraus zu intensivieren.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: masterthesis , doc-type:masterThesis
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  • 9
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    Förderbanken im Wandel : Evolution zu nachhaltigen Transformationsbanken ; fünf Handlungsfelder für die Begleitung einer nachhaltigen Entwicklung (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-10-02
    Description: Förderbanken vergeben in Deutschland jährlich mindestens 200 Milliarden Euro an Mitteln für Investitionen, die sonst nicht oder sehr viel später umgesetzt werden könnten. Sie arbeiten im öffentlichen Auftrag und richten ihre Tätigkeit an gesellschaftlichen Zielen aus. Diese Ziele haben sich weiterentwickelt. Angesichts von Klimawandel, Energiekrise und den Herausforderungen einer Kreislaufwirtschaft wollen sowohl die Länder als auch die Bundesregierung ihre Förderbanken umbauen. Gerade die Förderbanken der Länder müssen sich darum jetzt bereit machen für die "Weiterentwicklung von Förderbanken zu Transformationsbanken". Für die erfolgreiche Gestaltung dieses gesellschaftlichen Umbruchs brauchen sie Unterstützung. Wie dies gelingt, zeigt dieser Zukunftsimpuls.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 10
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    Klimaschutz als Privileg? : Milieuspezifische Handlungsbefähigung von Schüler*innen in Bezug auf den Klimawandel (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-10-02
    Description: Junge Menschen sehen sich durch die Klimakrise einer Einschränkung ihrer Entfaltungs- und Lebensmöglichkeiten gegenübergestellt. Diese explorative Studie verdeutlicht, wie sowohl die Wahrnehmung der Klimakrise, die Verantwortungsattribution, die wahrgenommene Handlungswirksamkeit und die einschlägigen Sozialisationserfahrungen milieuspezifisch strukturiert sind. Informiert durch das Projekt Schools4Future wurden vier Leitfadeninterviews mit Schüler*innen zur Wahrnehmung und Deutung der Klimakrise geführt. Im dreischrittigen Kodierprozess der Grounded Theory konnten Muster der Betroffenheit, der Verantwortungsattribution und der Handlungsstrategien von vier jugendlichen Klimaaktivist*innen aus akademischen und prekären Herkunftsmilieus rekonstruiert werden. Während die sozial bevorteilten Jugendlichen sich als Betroffene und unter dem Fehlverhalten vorangehender Generationen leidende Gruppe wahrnehmen, sehen die sozial benachteiligten Jugendlichen die Klimakrise als ein systemisches Versagen neben anderen. Der medial so vertraute Aktivismus geht von dem gehobenen Milieu aus und verbindet sich mit Konsum als distinktive Praxis des klimafreundlichen Handelns. Im prekären Milieu zeigen sich andere Formen des stillen, konkreten und intrinsisch motivierten Engagements sowie das (schulische) Engagement als Investition in den individuellen, sozialen Aufstieg. Konsistenter Weise sehen sich die akademischen Jugendlichen als bevorteilt in der Bearbeitung der Klimakrise, dethematisieren aber, was die jungen Menschen aus dem sozial schwachen Milieu deutlich diagnostizieren: Der ökologische Fußabdruck ihres Konsums ist ungleich höher als der der benachteiligten Jugendlichen.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: bachelorthesis , doc-type:bachelorThesis
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  • 11
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    Metaanalyse zu Wasserstoffkosten und -bedarfen für die CO2-neutrale Transformation : Studie für den Landesverband Erneuerbare Energien NRW e.V. (LEE NRW) (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-06-27
    Description: Seit Veröffentlichung der vom Landesverband Erneuerbare Energien NRW beauftragten und durch das Wuppertal Institut durchgeführten Studie "Bewertung der Vor- und Nachteile von Wasserstoffimporten im Vergleich zur heimischen Erzeugung" Ende 2020 haben sich die Rahmenbedingungen für den Wasserstoffhochlauf in Deutschland zum Teil deutlich geändert. Darüber hinaus ist zwischenzeitlich eine Reihe von Klimaschutz- und Transformationsstudien erschienen, mit teilweise neuen und differenzierten Einschätzungen zu Wasserstoff-Kosten und -Entwicklungspfaden. Dazu gehören insbesondere die als "Big Five" der Klimaneutralitätsszenarien bezeichneten Publikationen sowie weitere, spezifische H2-Analysen. Vor diesem Hintergrund sind die Ziele der vorliegenden Studie: 1. Eine Aktualisierung der Metaanalyse der oben genannten Wasserstoff-Studie aus dem Jahr 2020 - bezogen auf Kosten- und Mengen-Bandbreiten für die zukünftige Produktion und Bereitstellung von grünem und, soweit möglich, blauem Wasserstoff für Deutschland. 2. Eine kritische Einordnung der absehbaren Wasserstoff-Nachfrage in Deutschland, welche von der Wahl der Nutzungssektoren abhängt. 3. Eine kritische Diskussion und Einordnung der künftigen Rolle von blauem Wasserstoff, also der Frage, ob und inwiefern er eine sinnvolle Übergangslösung zu grünem Wasserstoff darstellen könnte.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 12
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    Meta-analysis of the costs of and demand for hydrogen in the transformation to a carbon-neutral economy : study commissioned by the North Rhine-Westphalian Renewable Energy Association (LEE NRW e. V.) (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
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    Publication Date: 2023-10-25
    Description: The production of green hydrogen in Germany is more competitive than expected compared to imports. This is the key finding of a meta-analysis conducted by the Wuppertal Institute on behalf of the North Rhine-Westphalia Association for Renewable Energies (Landesverband Erneuerbare Energien NRW). The hydrogen study focuses primarily on the year 2030 and beyond - and confirms the advantages of green hydrogen produced in Germany from domestic renewable energies, especially when the evaluation is viewed from a holistic system perspective.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 13
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    Weniger ist Mehrwert : Exnovation und die urbane Verkehrswende ; Handlungsempfehlung für die aktive Gestaltung der Verkehrswende durch Exnovation (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-11-16
    Description: Das Ziel einer urbanen Verkehrswende ist klar definiert: mehr Fläche für städtisches Leben, weniger Lärm und klimaschädliche Emissionen und eine saubere Luft. Das bedeutet weniger Autoverkehr in den Städten und mehr Wege zu Fuß, mit dem Fahrrad, dem Tretroller oder mit dem öffentlichen Verkehr. Dabei reicht es nicht aus nur auf Innovationen und attraktive Alternativen zu setzen - es braucht auch Exnovation, also restriktive und reduzierende Ansätze für den Autoverkehr. Dieser Zukunftsimpuls zeigt, wie die urbane Verkehrswende durch Exnovation beschleunigt und richtungssicher umgesetzt werden kann, welche Hemmnisse es bei bisher umgesetzten deutschen und europäischen Projekten gibt und welche Strategie- und Handlungsempfehlungen sich daraus ableiten lassen.
    Keywords: ddc:380
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 14
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    Less is more - exnovation and the urban mobility transition : recommended course of action for implementing the sustainable mobility transition through exnovation (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-11-17
    Description: The objectives of the urban mobility transition have been clearly set out: gaining more space for urban living, reducing noise and emissions that have a negative impact on the climate and improving air quality. That means less traffic in cities and more trips made using environmentally-friendly modes of transport - i.e., walking, cycling or foot scooters or public transport. In transport policy, the focus is generally on innovative approaches to shaping the mobility transition. This paper aims to explain the concept of exnovation in the context of the urban mobility transition and to underpin it using specific practical examples. In the course of this process, it is intended to identify the obstacles that stand in the way of rolling out the concept on an area-wide basis in order to deduce strategies and courses of action for expanding the concept in the future.
    Keywords: ddc:380
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 15
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    Digitalisation for a sustainable food system : opportunities for shaping production and consumption ; a study commissioned by Huawei Technologies Deutschland GmbH (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-03-24
    Description: The food system faces a multitude of challenges, including high greenhouse gas emissions, threats to biodiversity, increased diet-related diseases due to unbalanced diets, and socially problematic complex supply chains. This requires not only a transformation of the agricultural economy but also a change in the diet and lifestyles of all consumers. Developing and using digital and technological innovations can help to solve these challenges. In this context, the study provides impulses on how digitalisation can contribute to transforming production and consumption and which prerequisites have to be given to achieve this. The study describes the approaches for digitalisation along the value chain. These include optimising the use of resources in agriculture - for example with the help of smart farming - and supporting consumers with digital tools and assistance systems - such as apps designed to support grocery shopping. In addition, new business models and a better connection between production and consumption processes are also possible. This includes, for example, new digital sales channels or tracking and communicating sustainability indicators such as CO2 emissions across all steps of the value chain in order to enable all stakeholders to take reliable action.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 16
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    Digitalisierung für ein nachhaltigeres Ernährungssystem: Potenziale zur Gestaltung von Produktion und Konsum ; eine Studie im Auftrag von Huawei Technologies Deutschland GmbH (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-03-24
    Description: Das Ernährungssystem steht vor einer Vielzahl von Herausforderungen, wie unter anderem: hoher Treibhausgas-Emissionen, der Gefährdung der Biodiversität, der vermehrten ernährungsbedingten Krankheiten durch unausgewogener Ernährung sowie sozial-problematischen komplexen Lieferketten. Das erfordert nicht nur eine Transformation der Agrarwirtschaft sondern auch einen Wandel in den Ernährungs- und Lebensstilen aller Konsumierenden. Digitale und technologische Innovationen zu nutzen und weiterzuentwickeln kann helfen, diese Herausforderungen zu lösen. Vor diesem Hintergrund liefert die vorliegende Studie des Wuppertal Instituts Impulse, wie die Digitalisierung dazu beitragen kann Produktion und Konsum umzugestalten und welche Voraussetzungen dafür gegeben sein müssen. Die Studie beschreibt die Ansatzpunkte für die Digitalisierung entlang der Wertschöpfungskette. Dazu zählen die Optimierung des Ressourceneinsatzes in der Landwirtschaft, etwa mithilfe von Smart Farming, die Unterstützung von Verbraucher*innen durch digitale Tools und Assistenzsysteme - beispielsweise mit Apps als Einkaufshilfe. Daneben erlauben auch neue Geschäftsmodelle und Rahmenbedingungen eine bessere Vernetzung von Produktions- und Konsumprozessen. Dazu gehören zum Beispiel neue digitale Absatzkanäle oder Prozessstufen-übergreifend Nachhaltigkeitskennzahlen wie beispielsweise CO2-Emissionen mitzuführen und zu kommunizieren, um allen Akteur*innen richtungssicheres Handeln zu ermöglichen.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Das petrochemische System in Deutschland und Westeuropa : regionale Analyse der Polymer-Produktion in Deutschland, den Niederlanden und Belgien ; Ergebnisse aus dem Forschungsprojekt "Green Feedstock for a Sustainable Chemistry - Energiewende und Ressourceneffizienz im Kontext der dritten Feedstock-Transformation der chemischen Industrie" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-07-07
    Description: Die Herstellung petrochemischer Grundstoffe ist sowohl energetisch als auch stofflich in Deutschland für rund 20 % der Nachfrage nach Mineralölprodukten verantwortlich. Das Gros fließt in die Produktion von Olefinen und Aromaten, welche als sogenannte Plattformchemikalien wiederum die Ausgangsbasis für die Herstellung von Polymeren und Kunststoffen darstellen. Letztgenannte sind von größter Relevanz für die Branche: Von den knapp 60 Milliarden Euro Umsatz, welche die deutsche petrochemische Industrie im Jahr 2021 generierte, entfiel gut die Hälfte auf das Marktsegment der Polymere. Daraus resultieren jedoch über die gesamte Wertschöpfungskette CO2-Emissionen von rund 50 Millionen Tonnen jährlich. Eine Transformation der heutigen auf fossilen Rohstoffen basierenden petrochemischen Industrie hin zu einem auf erneuerbaren Rohstoffen basierenden zirkulären System kann somit einen bedeutenden Beitrag zu einer primärenergetisch effizienten und klimaneutralen Wirtschaftsweise leisten. Das vom Wuppertal Institut geleitete Forschungsprojekt GreenFeed exploriert gemeinsam mit den Verbundpartnern Karlsruher Institut für Technologie und Deutsches Biomasseforschungszentrum mögliche Pfade hin zu einem solchen System. Vor diesem Hintergrund wird im vorliegenden Papier zunächst das heutige System der ökonomischen und stofflichen Synergiebeziehungen zwischen den Raffinerien und der chemischen Industrie analysiert. Im geografischen Fokus stehen dabei Deutschland und der ARRRA-Raum als bedeutendste Chemie-Region innerhalb Europas sowie inhaltlich der sehr relevante Teilbereich der Polymer-Produktion. Die Kerninhalte des Papiers sind: 1) Charakterisierung des petrochemischen Metabolismus in Deutschland, einschließlich Produktions-, Energie-, Feedstock- und Kohlenstoffbilanz sowie Infrastruktur- und Transport-Verflechtungen innerhalb dieses Systems und 2) regionale Vertiefungen in Form von insgesamt acht Steckbriefen über alle petrochemischen Kunststoff-Regionen in Deutschland sowie des Antwerpener und Rotterdamer Clusters.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Towards a net-zero chemical industry : a meta-analysis of recent scenario studies and roadmaps ; results from the research project "Green feedstock for a sustainable chemistry - Energiewende und Ressourceneffizienz im Kontext der dritten Feedstock-Transformation der chemischen Industrie" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-05-02
    Description: 22 years are left until the German target for climate neutrality should be reached. For the industrial sector, this implies a fundamental change and an acceleration of emission reduction, as from 2000 to 2021 the sector has reduced its greenhouse gas (GHG) emissions by only 13% (ERK, 2022). For the large structures, plants and assets that are characteristic for the energy intensive industrial sectors, the timespan implies no room for delay. One sector facing particular challenges is the chemical industry. Here, fossil resources are used not only for energetic purposes but for feedstock as well, in the petrochemical industry in particular. The efforts made in the petrochemical sector thereby not only affects the sectors own emissions, but the chemicals value chain at large, including the management of end-of-life products. The dependency on energetic resources for material use also means that there is a particular connection from the chemical industry to the energy system at large, which also entails special consideration. The chemical industry also has a particular relevance to the Antwerp-Rotterdam-Rhine-Ruhr-Area (ARRRA) which hosts several large petrochemical clusters in Germany as well as the Netherlands and Belgium, with complexly interlinked production chains. In reaching the climate targets, these regions especially face significant changes and may have the opportunity to position themselves as frontrunners for industrial transformation. That is, if a successful strategy can be found. In the recent years, numerous scenario analyses and roadmaps have been released drawing out pathways for chemical industries to develop in line with national and international climate targets. This can entail mapping of technological options, important prerequisites, particular challenges as well as important opportunities and timeframes. This meta-analysis summarizes and compares the findings of some of the most recent previous works at the national, European and global level. As the goal is to investigate the various strategic options and development paths for Germany and the ARRRA, it has a particular focus on roadmaps for Germany, the Netherlands and Belgium. It takes a quantitative as well as qualitative approach, looking both at resource and production volumes, different emission reduction strategies relative importance, as well as policy recommendations and other important framework conditions. A particular focus is put on the use of non-fossil feedstocks to reduce emissions.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 19
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    Wege zu einer Netto-Null-Chemieindustrie : eine Meta-Analyse aktueller Roadmaps und Szenariostudien ; Ergebnisse aus dem Forschungsprojekt "Green Feedstock for a Sustainable Chemistry - Energiewende und Ressourceneffizienz im Kontext der dritten Feedstock-Transformation der chemischen Industrie" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-05-02
    Description: Die chemische Industrie ist auch für die Antwerpen-Rotterdam-Rhein-Ruhr-Region (engl. Antwerp-Rotterdam-Rhine-Ruhr-Area, kurz ARRRA) von besonderer Bedeutung, die mehrere große petrochemische Cluster in Deutschland, den Niederlanden und Belgien mit komplex vernetzten Produktionsketten beherbergt. Bei der Umsetzung der Klimaziele stehen diese Regionen vor bedeutenden Veränderungen und haben zugleich die Chance, sich als Vorreiter der Industrietransformation zu positionieren. Dafür müssen erfolgreiche Strategien für den Wandel identifiziert und angewendet werden. In den letzten Jahren wurden zahlreiche Szenarioanalysen und Roadmaps veröffentlicht, in denen Entwicklungspfade für die chemische Industrie im Einklang mit nationalen und internationalen Klimazielen aufgezeigt werden. Diese können eine Darstellung von technologischen Optionen, wichtigen Voraussetzungen, besonderen Herausforderungen sowie bedeutsamen Chancen und zeitlichen Entwicklungen beinhalten. Die vorliegende Metaanalyse fasst die Ergebnisse einige der aktuellsten Arbeiten auf nationaler, europäischer und globaler Ebene zusammen und vergleicht diese kritisch miteinander. Da das Kernziel der vorliegenden Analyse darin besteht, die verschiedenen strategischen Optionen und Entwicklungspfade für Deutschland und die ARRRA zu untersuchen, liegt der Schwerpunkt der Arbeit auf Publikationen mit Fokus Deutschland, den Niederlanden und Belgien. Dabei wird sowohl ein quantitativer als auch ein qualitativer Ansatz verfolgt, der die Ressourcen- und Produktionsmengen, die relative Bedeutung verschiedener Emissionsminderungsstrategien sowie auch politische Empfehlungen und andere wichtige Rahmenbedingungen berücksichtigt. Der Fokus liegt dabei auf Strategien für den Einsatz alternativer nicht-fossiler Feedstocks und die Minderung damit verbundener Emissionen.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 20
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    Regionales Ressourcenmanagement am Beispiel der metallverarbeitenden Industrie im Bergischen Städtedreieck : Stakeholderanalyse und ökologische Potentialanalyse ; Abschlussbericht der Arbeitspakete 2 und 4 des Teilprojektes im Rahmen des Verbundvorhabens "Urbane Produktion im Bergischen Städtedreieck" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-01-20
    Description: Die Kaskadennutzung von hochwertigen Materialien wie hochlegierten Metallen, also die Weiternutzung von Werkstoffen mittels Re-engineering beziehungsweise Reuse oder Re-manufacturing von Bauteilen oder Materialien, birgt in Kombination mit integrierten innovativen Produkt-Dienstleistungsmodellen ein hohes Potenzial für Ressourcenschonung und Klimaschutz. Denn über diesen Ansatz können hochwertige Materialien, die meist energieintensive Fertigungsverfahren unterlaufen, länger in der Nutzung gehalten werden. So kann der Zeitpunkt des Recyclings verzögert werden, welches insbesondere bei hochwertigen Materialien meist zu Qualitätsverlusten führt. Auf diese Weise kann der Bedarf an der Primärproduktion und entsprechend die ökologischen Wirkungen verringert werden. Gerade durch die regional hohe Dichte an produzierendem Gewerbe im metallbe- und -verarbeitenden Bereich bietet sich das Bergische Städtedreieck an für ein regional integriertes Ressourcenmanagement an. Das Projekt RegRess trägt mit dazu bei, die Hürden zur Etablierung eines entsprechenden Ressourcenmanagements mit dem Fokus auf das Bergische Städtedreieck zu senken, um so ökonomische und ökologische Potenziale für die regionale Wirtschaft und Profilbildung der Unternehmen, insbesondere KMU, zu heben. Dieser Bericht dokumentiert die Ergebnisse einer Stakeholder-/Netzwerkanalyse von der regionalen bis zur nationalen Ebene als Basis für Kooperationen. Die Analyse identifiziert mittels Desktoprecherche 110 Netzwerke, von denen ca. 25 unmittelbar im Bergischen Städtedreieck tätig sind bzw. die Region abdecken. Darüber hinaus wird eine Methodik und deren Anwendung anhand von theoretischen Beispielen vorgestellt, um den ökologisch sinnvollen Einsatz von Kaskadennutzung aufzuzeigen und zu reflektieren. Die Methodik wurde auf die Beispiele der Kaskadennutzung ausgedienter Spiralbohrer sowie Kochtöpfe angewendet, wobei beide Beispiele tendenziell ökologische Einsparpotentiale aufweisen. Unter Vorbehalt einer detaillierteren Lebenszyklusanalyse wurden bei den Spiralbohrern bei einmaliger Kaskadierung Einsparungen in der Größenordnung von maximal 75 % beim Material Footprint und 60 % beim Carbon Footprint abgeschätzt. Aufgrund der aufwändigeren Form und höheren Reinigungsaufwänden liegen die Einsparungen beim Kochtopf geringer und wurden beim Material Footprint auf eine Größenordnung von maximal 26 % und beim Carbon Footprint von 25% geschätzt.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Suffizienzpolitik als Booster zum Erreichen der Klimaschutzziele (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-14
    Description: Im September 2023 sind zwei wenig ermutigende Untersuchungen veröffentlicht worden: Das Klimasekretariat der Vereinten Nationen macht in seinem Report zur ersten Globalen Bestandsaufnahme (Global Stocktake) deutlich, dass die bisher zugesagten nationalen Klimaschutzbeiträge bei weitem nicht genügen, um die Pariser Klimaschutzziele zu erreichen. Auch das Update zur Einhaltung der planetaren Grenzen fällt ernüchternd aus: In sechs von neun Bereichen sind die Grenzen teils weit überschritten - auch in Bezug auf den Klimawandel. Allerdings reichen die ergriffenen Klimaschutzmaßnahmen nicht aus, um die gesteckten Ziele zu erreichen. Suffizienzstrategien und -politik können den Wandel bringen - bei Konsum, Gebäuden, Verkehr, Kreislaufwirtschaft und Energie, wie der Zukunftsimpuls zeigt.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: workingpaper , doc-type:workingPaper
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    Case study on the German discourse of industry decarbonisation : a discourse network analysis (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-14
    Description: The adoption of the Paris Agreement in 2015 and the passing of the Climate Action Law in Germany in 2019 established the legal need for the basic material industry in Germany to decarbonise. For the industry sector, the target is sets at a 49-51% GHG reduction by 2030 compared to 1990. Even though the sector specific targets are likely to become obsolete, a Hydrogen Strategy, Industry Strategy and Climate Protection Contracts are currently being developed or elaborated on. These are to further ensure and enable the basic material industry in Germany to decarbonise. These developments are emphasising the relevance of studying the industry decarbonisation at the time of conducting this research. As the institutionalisation of the industry decarbonisation is influenced by discourse, the analysis of the discourse is an important tool for studying the power effects produced by and built into the discourse. This is the first research aiming to provide a structured analysis of the discourse on industry decarbonisation in Germany. Drawing on discourse analysis and the Multilevel-Perspectives framework, this research investigated the power and dominance of storylines to influence the discourse of the industry transformation towards decarbonisation. In this research insights were obtained into the storylines used in this discourse, the actors who are part of this discourse, the frequency of storylines used and the percentage of actors making use of these storylines. Additionally, insights were generated into the discursive network and potential coalitions. This research made use of the Discourse Network Analysis software in combination with Visone and Excel for data collection, analysis, and visualisation. Based on 117 documents of various categories from the years 2012 to 2023, the discourse on German industry decarbonisation is discovered to be dominated by storylines of mainly technological or economic nature. The general sentiment discovered by the different actors is positive with the storylines focusing on establishing the conditions for the industry to decarbonise and no resistance being communicated. The discourse is furthermore dominated by most storylines. 18 out of 27 storylines are being used by more than 56% of all actors. The high overlap in storyline indicates discursive homogeneity. The homogeneity is further indicated through the lack of emerging discourse coalitions and the therewith connected lack of struggles for discursive dominance. One coalition can be defined with some actors being deeper involved and some being less involved in the discourse. As decisions on the transition path for Germany's industry to decarbonise are still to be taken the lack of discursive struggles has come to my surprise. In the discussion I reflect on how the positive sentiment, the discursive homogeneity and the great number of dominant storylines may come about.
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: masterthesis , doc-type:masterThesis
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    Wie bleiben gemeinschaftliche Wohnprojekte beständig? : Eine qualitative Analyse der Beständigkeit von gemeinschaftlichen Wohnprojekten in Hinblick auf die nachhaltige Stadtentwicklung (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-14
    Description: Die Schaffung von bezahlbarem und sozial gerechtem Wohnraum stellt eine zentrale Herausforderung der nachhaltigen Stadtentwicklung dar. Zur Begegnung dieser Herausforderungen spielen innovative Wohnformen wie gemeinschaftliche Wohnprojekte eine bedeutende Rolle, da sie vielfältige soziale Nachhaltigkeitsaspekte aufweisen und dadurch zu einer nachhaltigen Stadtentwicklung beitragen können. In diesem Kontext bleibt die Frage offen, ob die Gemeinschaften in Wohnprojekten nach ihrer Gründung beständig bleiben. Das Ziel der Arbeit war die Beantwortung der folgenden Forschungsfrage: "Wie können gemeinschaftliche Wohnprojekte dauerhaft in Bezug auf ihre Weiterentwicklung bestehen bleiben und somit langfristig eine nachhaltige Stadtentwicklung unterstützen?" Zur Beantwortung der Forschungsfrage wurde eine qualitative Studie in Form von narrativen Interviews mit Bewohner:innen gemeinschaftlicher Wohnprojekte durchgeführt. Die Ergebnisse aus Literatur und Praxis konnten acht besonders relevante Faktoren für die Beständigkeit von gemeinschaftlichen Wohnprojekten identifizieren: Soziale Durchmischung, Organisationsstruktur, Gemeinschaftspflege, Vertrauen, Soziales Netzwerk, Kommunikationskultur, gelebte Nachhaltigkeit, Flexibilität und Anpassungsfähigkeit. Diese Faktoren ermöglichen eine nachhaltige und anpassungsfähige Gemeinschaft, welche zu einer nachhaltigen Stadtentwicklung beitragen kann. Dafür sollten gemeinschaftliche Wohnprojekte ihre vorhandenen Potenziale weiterhin ausbauen.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: masterthesis , doc-type:masterThesis
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    D7.2 conclusive policy recommendations guide : version 1: EU and general policy recommendations ; QualDeEPC H2020 project (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: The original objectives for introducing Energy Performance Certificates (EPCs) were 1) to make energy performance transparent in the building market, as a measure of energy costs of using a building that a potential buyer or tenant would be interested in; and 2) to encourage energy efficiency renovation. However, the current implementation of EPC schemes in the Member States still shows significant challenges in achieving these two objectives. The recast of the EU Directive on the Overall Energy Performance of Buildings (EPBD) provides a chance to enhance both the usefulness and quality of EPCs and the EPC schemes overall. This document aims to inform both the debate on the recast of the EPBD and the enhancement of national EPC schemes in EU Member States. It presents the draft policy recommendations of the Horizon 2020 QualDeEPC project for making the EPBD and the national schemes more effective, particularly for deep renovation, and enhance their quality overall. The policy recommendations particularly target the link between EPCs and deep (energy) renovation1, while increasing the levels of ambition and convergence across the EU in terms of building renovation. Deep (energy) renovation is crucial for mitigating climate change and for energy security. The EPBD and all of its articles, as well as national EPC schemes, should aim to make deep (energy) renovation the default. This objective would be embedded and ensured in EPC schemes, if the policy recommendations provided in this document were adopted and implemented.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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    The energy transition in Colombia : current situation, projections, challenges, narratives and public policies - in relation to the energy transition in Germany (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: This Wuppertal Paper analyses the energy transition models of Colombia and Germany. The emphasis of the exercise is on an analysis of options for the complete decarbonization of the energy system in Colombia as a Global South country. To this end, it analyses the current situation, projections, public policy and narratives, and contrasts it with Germany as one of the countries of the Global North with which Colombia has historically maintained energy trade relations and is currently collaborating in the exploration of energy alternatives for decarbonization. Detailed analysis of sectoral energy consumption in Colombia shows the sectors with the highest fossil energy consumption (in this order): transport (fuels), industry (gas, coal), electricity generation (gas, coal) and residential (gas). We show the projected increase in demand for fuels and electricity, and calculate the amount of electricity theoretically needed to substitute fossil sources in each sector. We estimate the total electricity required for decarbonization via sector coupling and derive a first estimation of the range of additional renewable energy capacities needed to supply this demand. We find that required capacities are expectedly large (56-110 GW), depending on decarbonization pathways, and that export capacity beyond national demand may be limited. Our analysis of the policy and scenario arena in both countries finds that Colombia is still lacking both sector-specific decarbonization strategies and an embedding in a systemic vision of a systemic energy transition. Germany has more advanced sector strategies and (national) systemic visions, but lacks embedding assumptions on energy imports in a global-system analysis, i.e. in the analysis of an energy transition in potential exporting countries like Colombia. We formulate requirements to close these gaps in our conclusions.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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    Explorationsstudie Klimawandel und Gesundheit : Studie im Auftrag der BARMER (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: Der Klimawandel wird zunehmend eine der größten Gesundheitsbedrohungen des 21. Jahrhunderts. Die Weltgesundheitsorganisation (WHO) erwartet, dass durch die Folgen des Klimawandels zwischen den Jahren 2030 und 2050 rund 250.000 zusätzliche Todesfälle pro Jahr durch Mangelernährung, Malaria, Durchfallerkrankungen und Hitzestress verursacht werden. Allein für die direkten Gesundheitsschäden - also ohne beispielsweise indirekte Schäden, die in Sektoren wie der Landwirtschaft entstehen - werden bis 2030 Zusatzkosten von jährlich zwei bis vier Milliarden US-Dollar erwartet. Besonders betroffen sind Menschen in Gegenden mit einer schlechten Gesundheitsversorgung und Infrastruktur. Aber auch Deutschland ist von den Folgen des Klimawandels betroffen – heute und künftig. Aktuell liegt in der Forschung noch ein Fokus darauf, zu untersuchen, in welcher Art und Weise die Menschen dem Klimawandel ausgesetzt sind (Expositionswege) und wie sich diese Gesundheitseffekte messen lassen (etwa der Unterschied der Gesundheitsauswirkungen einer globalen Durchschnittserwärmung von 1,5 oder 2 Grad Celsius). Auch wird das klimawandelbedingte Gesundheitsrisiko verschiedener Bevölkerungsgruppen von zahlreichen nationalen und internationalen Akteuren erforscht. Einer der Forschungsschwerpunkte bildet dabei die Untersuchung unterschiedlicher Anfälligkeiten für klimabedingte Gesundheitsrisiken verschiedener Gruppen (bspw. ältere Menschen, Vorerkrankte, Einkommensschwache, Kinder). Andere Studien widmen sich dem Risiko, dem Menschen in ausgewählten geografischen Regionen (etwa Brasilien) oder Angehörige bestimmter Völker (bspw. Gesellschaften in der Arktis) ausgesetzt sind. Ein noch junges Forschungsfeld umfasst Untersuchungen zur Klimaangst (climate anxiety). Gemeinsam mit der gesetzlichen Krankenkasse BARMER hat das Wuppertal Institut sich zum Ziel gesetzt, innerhalb des Projekts "BARMER Explorationsstudie Klimawandel und Gesundheit" den aktuellen Forschungsstand zu den Auswirkungen des Klimawandels auf die Gesundheit aufzubereiten. Die Aufarbeitung erfolgt über vier Arbeitspakete (Module) hinweg. Der vorliegende Projektbericht fasst die zentralen Projektergebnisse zusammen.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    D5.3 guidebook for improved EPCs presenting the project's proposal for an enhanded and converging EPC assessment and certification scheme : consolidated results ; QualDeEPC H2020 project (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: The QualDeEPC project is aiming to both improve quality and cross-EU convergence of Energy Performance Certificate schemes, and the link between EPCs and deep renovation: High-quality Energy Performance Assessment and Certification in Europe Accelerating Deep Energy Renovation. The objective of the project is to improve the practical implementation of the assessment, issuance, design, and use of EPCs as well as their renovation recommendations, in the participating countries and beyond. This report serves as a compilation of the project's proposal for an enhanced and converging EPC assessment and certification scheme. It aims to provide a detailed description on the set of practical concepts, policy proposals, and tools for an enhanced EPC scheme towards deep renovation, developed by the QualDeEPC project. The project's substantial proposals both on EU and national level are presented in a comprehensive and rational way, guiding the relevant stakeholders, in particular the policy makers and competed bodies, on which steps need to be followed so as the proposals to be adapted and how the specific values can be determined in MSs. Furthermore, this report includes the project's proposal for defining "Deep Energy Renovation" based on a modified nZEB-based approach. The project's priorities A) to G) addressed are presented in the following order in this document, reflecting the importance of the enhanced EPC template form and the training of EPC assessors in such schemes: A) Improving the recommendations for renovation, which are provided on the EPCs, towards deep energy renovation; E) High user-friendliness of the EPC, by way of an enhanced EPC template form, including an introduction of the proposed "Energy Rating" indicator; D) Regular mandatory EPC assessor training or examination on assessment and renovation recommendations, required for certification/accreditation and registry; B) Online tool for comparing EPC recommendations to deep energy renovation recommendations; C) Creating Deep Renovation Network Platforms (DRNPs); F) & G) Voluntary/mandatory advertising guidelines for EPCs and Improving compliance with the mandatory use of EPCs in real estate advertisement.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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    Kreislaufwirtschaft in NRW : Überblick über zentrale EU-Maßnahmen und ihre Relevanz für NRW ; Diskussionspapier zum Forschungsmodul 3a im Forschungsprojekt "Nachhaltigkeitsstrategie NRW - Vertiefungsanalysen zur Umsetzung aus wissenschaftlicher Sicht" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: Aufgrund der Wechselwirkungen mit sozialen, ökonomischen und ökologischen Zielen ist die Kreislaufwirtschaft möglicherweise ein Handlungsbereich mit systemischer Schubkraft für die integrierte Nachhaltigkeitsentwicklung von NRW. Sie ist deswegen auch für die Umsetzung der NRW-Nachhaltigkeitsstrategie, die 2016 zum ersten Mal aufgelegt und 2020 aktualisiert wurde, von besonderem Interesse. Aus diesem Grund hat sich das Wuppertal Institut im Rahmen des Forschungsprojekts "Nachhaltigkeitsstrategie NRW - Vertiefungsanalysen zur Umsetzung aus wissenschaftlicher Sicht" in einem Forschungsmodul mit der Umsetzung der Kreislaufwirtschaft im Kontext der Gesamtwirtschaft von NRW beschäftigt und hier insbesondere die Auswirkungen des europäischen, politischen Rahmens auf die Aktivitäten in NRW in den Blick genommen. Mit anderen Worten, das nachfolgende Arbeitspapier nimmt den European Green Deal und seine Bedeutung für NRW in den Blick und fragt: Welche Herausforderungen für NRW lassen sich aus dem Green Deal ablesen, wie und in welchen Sektoren kann/soll NRW eine Transformation zur Kreislaufwirtschaft einleiten und welche Bedingungen müssen dabei beachtet werden? Methodisch basiert diese Auswertung auf der Analyse relevanter Primärdokumente sowie der Sekundärliteratur zur Umsetzung der Kreislaufwirtschaft im politischen Mehrebenensystem. Dabei soll das Papier kein industriepolitisches Innovationsprogramm entwerfen, sondern eine Handreichung zur weiteren Diskussion von potenziellen Maßnahmen und Politikvorschlägen im Hinblick auf die zu entwickelnde Kreislaufwirtschaftsstrategie darstellen.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Wie beeinflussen Protestbewegungen die öffentliche Akzeptanz von Technologien für die Industrietransformation in NRW? : Ein exploratives Protest-Akzeptanz-Modell (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: Um die Treibhausgasneutralität bis 2045 zu erreichen, wird unter anderem erforderlich sein, dass die Industrie klimaneutrale Produktionsweisen entwickelt und umsetzt. Damit einher gehen gesellschaftliche Aushandlungsprozesse darüber, welche neuen Technologien eingesetzt werden und welche Auswirkungen vor Ort akzeptiert werden. Das Ausmaß an Akzeptanz gegenüber Technologien oder Infrastrukturen beeinflusst neben anderen Faktoren die spezifische Ausgestaltung der Transformation. Mangelnde Akzeptanz kann die Entwicklung von Transformationspfaden verlangsamen oder gar verhindern, und zu Protesten, beispielsweise von lokalen Initiativen oder von etablierten Klimaschutz- und Umweltverbänden, führen. Dieses Wuppertal Paper stellt die Frage in den Fokus, welchen Einfluss Protestbewegungen auf öffentliche Akzeptanz haben bzw. haben könnten. Grundlage dafür sind empirische Ergebnisse aus dem Projekt Protanz.NRW zu Protesten und Akzeptanz im Kontext der Industrietransformation in NRW. Darauf aufbauend wird ein Protest-Akzeptanz-Modell entwickelt und es werden Hypothesen abgeleitet, wie unterschiedliche Protestgruppen die öffentliche Akzeptanz von Technologien für die Industrietransformation in NRW beeinflussen können. Abschließend werden Handlungsempfehlungen für Politik und Industrie abgeleitet sowie Forschungsbedarfe aufgezeigt.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    D2.1 report on local EPC situation and cross-country comparison matrix : QualDeEPC H2020 project (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: Considering that 40% of the European Union's energy consumption can be traced back to its buildings, it is essential to improve their energy efficiency in order to achieve the EU's energy efficiency targets. Both the rate of energy renovation and its depth, i.e. the amount of energy savings during a renovation, need to be improved. Energy Performance Certificates (EPC), regulated by the EU's Energy Performance of Buildings Directive (EPBD), are an important instrument to enhance the market uptake of energy-efficient new buildings and the energy-efficient renovation of existing buildings. Against this background, the Horizon2020 funded project QualDeEPC will work on EU-wide convergence of the building assessment and the issuance, design, and use of quality-enhanced EPCs as well as their recommendations for building renovation. The aim is to make these recommendations coherent with deep energy renovation towards a nearly-zero energy building stock by 2050. The first part of the QualDeEPC project (work package 2) aims to identify the priorities for elements of EPC schemes that show a need to be improved, and for which the project will investigate further and propose how the elements can be improved. The first step in identifying these priorities is taking stock of the existing EPC schemes. Based on the input from all national consortium partners and other sources, the Wuppertal Institute prepared this detailed overview of the country-specific EPC assessment and certification procedures and their links to other policies and programmes, existing initiatives, and projects. The analysis was based on a list of almost 50 potential options for enhancing the existing EPC schemes. The aim of this deliverable is to present this stock-taking by a detailed analysis on which of the potential enhanced EPC elements are already implemented in which form in which country, covering all 28 countries that were EU member states until 31 January 2020. All partners conducted bilateral interviews with the major actors in the EPC procedures, including executive bodies on EPC at regional and/or national level. For countries not represented in the Consortium, Wuppertal Institut and EAP conducted specific literature research, e.g. from the Concerted Action EPBD, and aimed to obtain contributions from other member states. The information collected allows a detailed presentation on the elements implemented as well as a cross-country comparison matrix (see Annex I) in this report, which outlines the current EPC practices across the EU regarding the elements of a good practice scheme or innovative improvement options, their comparability, compliance with EU legislation, and to which extent they differ or converge. The results show, once more, the high diversity in EPC schemes across the EU. They also provide useful information in at least two directions: 1) which improvement options are not yet implemented at all or in sufficient quality in most QualDeEPC partner countries as well as other EU member states, and could therefore be interesting candidates for the further work of the QualDeEPC project in development, testing, discussion, and possibly implementation of elements for enhanced and converging EPC schemes; and 2) which countries, within or beyond the QualDeEPC project, offer good practice examples for the implementation of these options that could serve to guide the development and implementation in other countries. This deliverable will thus serve as a basis for the upcoming tasks to develop priorities and actual proposals for improvement of EPC schemes.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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    Circular Economy - Leitbild und Vision : Bericht zum Forschungsmodul E2 im Forschungsprojekt "Umsetzungserfahrungen mit Landesnachhaltigkeitsstrategien - Fallstudie Nachhaltigkeitsstrategie NRW" (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-22
    Description: Die Transformation der bisher linearen Strukturen von Produktion und Konsum ("take-make-dispose") hin zu einer Circular Economy (CE) - im Sinne einer weiterentwickelten Kreislaufwirtschaft - gilt als zentrales Konzept zur Steigerung der Ressourceneffizienz und Kreislaufführung von Materialien und Produkten, zur Stärkung der Wettbewerbsfähigkeit der einheimischen Industrie sowie zur Schaffung neuer Arbeitsplatzpotenziale. Ziel dieses Forschungsmoduls ist es, die bisherige Umsetzung dieses Konzepts im Rahmen der Nachhaltigkeitsstrategie NRW zu analysieren und durch geeignete Impulse zu begleiten. Durch die Entwicklung eines Leitbilds für eine nachhaltige Circular Economy und zu seiner Messung geeigneter Indikatoren soll das noch an vielen Stellen unscharfe Konzept präzisiert und insbesondere an die spezifischen Ausgangsbedingungen und Herausforderungen von Nordrhein-Westfalen angepasst werden. Dazu sollen Bausteine für ein mittel- und langfristiges Leitbild (2030) entworfen werden, das einen konsistenten Entwicklungspfad für diesen komplexen Transformationsprozess beschreiben soll. Die bestehenden stark abfallwirtschaftlich geprägten Indikatoren zum Thema Kreislaufwirtschaft sollen durch Vorschläge für zusätzliche Indikatoren zur Nachhaltigkeit im Rahmen der Kreislaufwirtschaft (Circular Economy, CE) ergänzt werden.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Extended Producer Responsibility (EPR) in der Matratzenindustrie : Evaluierung verschiedener EPR-Modelle für Deutschland hinsichtlich ihrer Umsetzbarkeit und Effektivität zur Kreislaufschließung (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2023-12-21
    Description: In Deutschland werden jährlich über sieben Millionen gebrauchte Matratzen entsorgt, die überwiegend verbrannt und nur zu einem Bruchteil recycelt werden. Dieser lineare Ansatz belastet die Ressourcen, erhöht die Emissionen und birgt Umweltrisiken. Um diesen Herausforderungen zu begegnen, kann die erweiterte Herstellerverantwortung (Extended Producer Responsibility, EPR) als Instrument zur Umsetzung einer Kreislaufwirtschaft dienen. In dieser Masterarbeit wird daher untersucht, wie ein EPR-System für Matratzen in Deutschland gestaltet sein sollte, um Kreisläufe effizient zu schließen. Gleichzeitig zielt diese Thesis darauf ab, die damit verbundenen Anforderungen und Herausforderungen bei der Umsetzung eines solchen Systems zu identifizieren. Zur Beantwortung der Forschungsfragen wurden mithilfe von Expert*innen-Interviews und einer umfassenden Literaturrecherche drei EPR-Modelle entwickelt und anhand von ausgewählten Kriterien bewertet. Die Ergebnisse der Bewertung ergaben, dass ein Modell präferiert werden sollte, in dem eine sogenannte Producer Responsibility Organisation (PRO) gebündelt die Verantwortung der Hersteller übernimmt. Ein solches System würde unter anderem eine angemessene Kontrolle ermöglichen und Anreize für Forschung und Entwicklung im Bereich der Recyclingtechnologien und des zirkulären Designs der Matratzen schaffen. Obwohl die Datenlage über Altmatratzen und deren Verwertung in Deutschland derzeit noch begrenzt sind und die hier präsentierten Ergebnisse von der gewählten Methodik abhängen, dient diese Masterarbeit als erste Grundlage für die weitere Entwicklung eines EPR-Systems für Matratzen in Deutschland.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Flächennutzung optimieren, Neubaudruck reduzieren : OptiWohn - Quartiersspezifische Sondierung und Entwicklung innovativer Strategien zur optimierten Nutzung von Wohnflächen ; Schlussbericht (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-04-04
    Description: Mit verschiedenen Wohnbauoffensiven versuchen viele Kommunen dem vorherrschenden Wohnraummangel entgegenzuwirken. Der Neubau von Häusern nimmt viel Fläche in Anspruch und verbraucht viele Ressourcen. Dabei lässt sich ein Großteil des Wohnraumbedarfs durch bestehende Wohngebäude decken, wenn sich Menschen an biografischen Wendepunkten, wie etwa Auszug der Kinder, für kleinere Wohnflächen und alternative Wohnkonzepte entscheiden würden. Das Projekt OptiWohn ging darum der Frage nach, wie eine optimierte Nutzung der Wohnfläche proaktiv gefördert werden kann. Herzstück bildet die Entwicklung und Gründung von kommunalen Wohnraumagenturen. Sie identifizieren Wohnraumbedarfe im Quartier, bieten Beratung für Wohnungssuchende an, vermitteln alternative Wohnungen oder initiieren Angebote zum Wohnungstausch. Neben dem Beratungs- und Förderangebot zur Optimierung der Wohnflächennutzung in den Städten Köln, Göttingen und Tübingen wurden die Ergebnisse in kommunale Handlungsempfehlungen übertragen, die neben Städten und Kommunen auch weitere Akteure ansprechen sollen. Darüber hinaus entwarfen die Wissenschaftlerinnen und Wissenschaftler ein bundesweites Förderprogramm für flächeneffizientes Wohnen.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Strategies, concepts and measures for decarbonizing the building stock by 2045/50 (2023)
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publication Date: 2024-04-05
    Description: Established in 2016, the German-Japanese Energy Transition Council (GJETC) strives to promote bilateral cooperation between Germany and Japan on energy transition. Among other studies and topical papers, an output paper in 2020 (Rauschen et al., 2020) already compared the energy efficiency in buildings in both countries with a particular focus on heating and cooling. One important finding of this output paper was that further efforts in the building sector are needed to improve the energy efficiency of buildings in Germany and Japan. Following the more ambitious climate protection targets in both countries, this study seeks to analyze the German and Japanese policies put in place to accelerate the decarbonization of the building sector. The decarbonization of the vast number of buildings that both Japan and Germany are facing will be a major contribution to achieving the GHG reduction targets of both countries and should continue to be discussed among experts and developed into a discussion among policy makers. This report examines and compares the characteristics of the building stock in both countries, as well as existing policies and new strategies and policies that are planned or discussed to achieve energy conservation and decarbonization of buildings. The current shape of buildings, especially houses, is greatly influenced by the land area of the country corresponding to the available space for buildings, the natural environment surrounding the country, the natural resources available, and the lifestyle and cultural ideas that have been passed down and taken root over time. Therefore, it might be difficult to compare them and the corresponding strategies and policies with the same yardstick, so we also discuss common or deviant situations. Through this joint research, we aim to find each other's advantages and challenges and to develop useful and concrete policy recommendations that will contribute to decarbonization policies in both countries.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 35
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    Online Resource
    Fuzzy Sets Methods in Image Processing and Understanding : Medical Imaging Applications (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Computer vision. ; Radiology. ; Biotechnology. ; Computer Vision. ; Radiology.
    Description / Table of Contents: Introduction -- Preliminaries -- Fuzzy spatial objects (fuzzy geometry and topology, set theoretic operations) -- Mathematical morphology -- Distances and similarities between fuzzy sets -- Machine learning in image processing and understanding -- Fusion -- Spatial relations -- Structural representations.
    Abstract: This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing. This book also: Enriches reader understanding of the latest fuzzy sets methods using higher level information (object or scene level) for advanced tasks, such as image understanding Shares many insights into fuzzy spatial objects, including fuzzy geometry and topology as well as set theoretical operations Covers in detail machine learning in image processing and understanding, with special focus on clustering, classification, and basic and advanced fuzzy methods .
    Type of Medium: Online Resource
    Pages: XIII, 302 p. 97 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194252
    URL: https://doi.org/10.1007/978-3-031-19425-2
    DOI: 10.1007/978-3-031-19425-2
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Sustainable Forest Management in the Himalaya (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Geography. ; Biotic communities. ; Forestry. ; Regional Geography. ; Ecosystems.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Forest Land Use/Cover Change -- Chapter 3. Forest Classifications and Working Circles -- Chapter 4. National Parks, Wildlife Sanctuaries, and Conservation Reserves -- Chapter 5. Forest Diversity and Distribution -- Chapter 6. Forest Stocks and Products -- Chapter 7. Environmental Index -- Chapter 8. Ecosystem Goods and Services -- Chapter 9. Drivers of Forest Degradation and Conservation Measures -- Chapter 10. Climate Change and Forests -- Chapter 11. Cultural and Socio-Economic Significance of Forests -- Chapter 12. Sustainable Forest Management -- Chapter 13. Conclusions.
    Abstract: This volume presents a comprehensive description of forests of the Uttarakhand Himalaya. It looks into the major drivers of forest depletion and suggests paths toward sustainable forest management. The book comprises thirteen chapters, which together describe forest land use/cover change; forest classification and working circles; national parks, wildlife sanctuaries, and conservation reserves; forest diversity and distribution; forest stocks and products; ecosystem goods and services; environmental index; drivers of forest degradation and conservation; climate change and forests; cultural and economic significance of forests, and sustainable forest management. The text is richly complemented by nearly seventy photographs and figures.
    Type of Medium: Online Resource
    Pages: XXX, 172 p. 71 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219368
    URL: https://doi.org/10.1007/978-3-031-21936-8
    DOI: 10.1007/978-3-031-21936-8
    DDC: 634.9
    Language: English
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  • 37
    Online Resource
    Online Resource
    Mexican Fauna in the Anthropocene (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Vertebrates. ; Invertebrates. ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Vertebrate Zoology. ; Invertebrate Zoology.
    Description / Table of Contents: 1.1 General Introduction Principal -- 2. Zoloogical Groups -- 2.1 Arachnids -- 2.2 Insects: Migrants, endemics, and old to new pests -- 2.3 Freshwater decapod crustaceans: the challenges of documenting and preserving a very diverse fauna -- 2.4 Mexican molluscs: In the process of a 'silent extinction' -- 2.5 Amphibians and reptiles -- 2.6 Anthropocene impacts on the Mexican freshwater fish fauna -- 2.7 Mexican avifaunas of the Anthropocene -- 2.8 Marine birds -- 2.9 Terrestrial mammals -- 2.10 Marine mammals -- 2.11Mexican bats: conservation challenges in the Anthropocene -- 3. Ecosytems -- 3.1 The impact of the growth of urban environments on Mexican fauna -- 3.2 Anchialine fauna of the Yucatan Peninsula -- 3.3 Semi-terrestrial and aquatic invertebrates and fish in mangroves in México -- 3.4 Defaunation of Mexican tropical forests3.5 Mezcal boom and extinction debts in Mexican arid ecosystems -- 3.6 Deep sea life -- 3.7 The importance of agroecosystems for the Mexican fauna -- 3.8 The salamanders of the Mexican cloud forest -- 3.9 Human effects on caves in Mexico -- 3.10 Fauna of lakes and rivers -- 3.11 Coral reef faunal assemblages in the Mexican Caribbean: assessing the cryptic biodiversity -- 4 Processes -- 4.1 Contemporary climate change impacts on Mexican fauna -- 4.2 Invasive alien species of invertebrates and fishes introduced to Mexican freshwater systems -- 4.3 Are marine fisheries sustainable? -- 4.4 Pest dynamics in Mexican forests -- 4.5 Pollination by wild and managed animal vectors -- 4.6 Social participation strategies for the conservation of Mexican fauna -- 4.7 Citizen science for deep ocean biodiversity: a crowdsourcing tool in support of conservation -- 4.8 Legal actions for the conservation of fauna.
    Abstract: This contributed volume presents an analysis of the current conservation status of major faunal groups in Mexico. The chapters describe a prognosis of future challenges, and also explore the expanding threats inherent in the Anthropocene within the context of the unique physical, biological and cultural aspects of the nation. Covering 27 chapters, and written by Mexican and international authors, this book analyzes a wide range of vertebrate and invertebrate animal taxa, their ecosystems and the critical processes related to their present conservation status. This volume is an important reference material for researchers, conservationists and students interested in the biological and ecological processes shaping the Mexican fauna.
    Type of Medium: Online Resource
    Pages: XVII, 597 p. 50 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031172779
    URL: https://doi.org/10.1007/978-3-031-17277-9
    DOI: 10.1007/978-3-031-17277-9
    DDC: 333.95
    Language: English
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    Online Resource
    Online Resource
    Southern Baltic Coastal Systems Analysis (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Abstract: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031136825
    Series Statement: Ecological Studies, Analysis and Synthesis, 246
    URL: https://doi.org/10.1007/978-3-031-13682-5
    DOI: 10.1007/978-3-031-13682-5
    DDC: 577.6
    Language: English
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    Prions and Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    URL: https://doi.org/10.1007/978-3-031-20565-1
    DOI: 10.1007/978-3-031-20565-1
    DDC: 612.8
    Language: English
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    Primates in Anthropogenic Landscapes : Exploring Primate Behavioural Flexibility Across Human Contexts (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Zoology. ; Human evolution. ; Anthropology. ; Physical anthropology. ; Animal culture. ; Zoology. ; Evolutionary Anthropology. ; Physical-Biological Anthropology. ; Animal Science.
    Description / Table of Contents: Introduction -- Part 1-Human Influences on Primate Habitats -- Forest Fragmentation -- Primates in Regenerating Forest -- Responses of primates to roads: Dispersal barriers, mortality, and secondary effects -- Hunting by humans -- Primate-dog interactions -- Primate Tourism -- Infectious disease -- Climate change impacts on non-human primates – what have we modelled and what do we do now? -- PART 2: PRIMATES IN HUMAN-DOMINATED LANSCAPES -- Community-based conservation strategies to promote primate conservation in agricultural landscapes -- Translocated primate populations -- Translocated primate populations -- Exploring the human-primate interface -- Planning primate conservation in shared landscapes -- Non-pathogenic influences on primate health and behaviour -- PART 3: PRIMATES IN CAPTIVITY -- Anthropogenic and observer effects on primate behaviour: Perspectives on the continuum of wild-captive behaviour -- The primate pet trade -- Rescue, rehabilitation, and reintroduction.
    Abstract: The field of primatology has expanded substantially in the last twenty years, particularly with regard to studies of primates in human-altered landscapes. This text aims to review the recent literature on anthropogenic (of human origin) influences on non-human primates, bringing an overview of this important area of primatology together for students. Chapters are grouped into three sections, representing the many ways anthropogenic activities affect primate populations. The first section, ‘Human Influences on Primate Habitat’, covers ways in which wild primates are affected by human actions, including forest fragmentation, climate change, and the presence of dogs. Section two, ‘Primates in Human-Dominated Landscapes’, looks at situations where non-human primates and humans share space; this includes primates in urban environments, primate tourism, and primates in agroecosystems. The final section, ‘Primates in Captivity’, looks at primate behaviour and welfare in captive situations, including zoos, the primate pet trade, and in entertainment.
    Type of Medium: Online Resource
    Pages: XIII, 346 p. 36 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117367
    Series Statement: Developments in Primatology: Progress and Prospects,
    URL: https://doi.org/10.1007/978-3-031-11736-7
    DOI: 10.1007/978-3-031-11736-7
    DDC: 590
    Language: English
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    Basic and Clinical Immunology by Names : From the Biblical Time Until the Present (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    URL: https://doi.org/10.1007/978-3-031-14529-2
    DOI: 10.1007/978-3-031-14529-2
    DDC: 571.96
    Language: English
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    The Secret Lives of Transcription Factors : In Heterochromatin Regulation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Physiology. ; Medical genetics. ; Cell Biology. ; Physiology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
    Abstract: This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
    Type of Medium: Online Resource
    Pages: VI, 45 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031290299
    Series Statement: SpringerBriefs in Biochemistry and Molecular Biology,
    URL: https://doi.org/10.1007/978-3-031-29029-9
    DOI: 10.1007/978-3-031-29029-9
    DDC: 571.6
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    Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Cytology. ; Clinical biochemistry. ; Proteins . ; Ageing. ; Cell Biology. ; Medical Biochemistry. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1:Introduction: Historical Development and Progression of Clinical Research on Ageing -- Chapter 2:Bone Cells Metabolic Changes Induced by Ageing -- Chapter 3:Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-related Diseases -- Chapter 4: Heart Disease and Ageing: The roles of Senescence, Mitochondria and Telomerase in Cardiovascular Disease -- Chapter 5: Chronic Kidney Disease and the Exposome of Ageing -- Chapter 6: Sarcopenia and Ageing -- Chapter 7: Tendon Ageing -- Chapter 8: Virus Infections in Older People -- Chapter 9: Models and Biomarkers for Ovarian Ageing -- Chapter 10: Ageing and the Autonomic Nervous System -- Chapter 11: Astrocytes in Ageing -- Chapter 12: Hearing and Ageing -- Chapter 13: Melatonin and Ageing -- Chapter 14: Protein and Energy Supplements for the Elderly -- Chapter 15: Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants -- Chapter 16: Clinical Ageing.
    Abstract: This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice. To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the ageing process. Additionally, this book discusses how phosphate metabolism and metabolic dysfunction contribute to ageing events and how various organs and tissues (e.g. tendons, ears, heart muscle, and the endocrine system) age. This book follows on from Parts I, II and III of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and aims to bring the subcellular and clinical areas into closer contact by including interesting and significant biomedical ageing topics that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.
    Type of Medium: Online Resource
    Pages: VIII, 458 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031265761
    Series Statement: Subcellular Biochemistry, 103
    URL: https://doi.org/10.1007/978-3-031-26576-1
    DOI: 10.1007/978-3-031-26576-1
    DDC: 571.878
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    Marine Mammals : A Deep Dive into the World of Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Zoology. ; Veterinary medicine. ; Freshwater ecology. ; Marine ecology. ; Zoology. ; Veterinary Science. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter 1. Who are the marine mammals? -- Chapter 2. Marine mammal acoustics -- Chapter 3. Whaling, seal culling, and the effect of fisheries on marine mammals -- Chapter 4. Plastic debris and its impacts on marine mammals -- Chapter 5. Chemical pollution and diseases of marine mammals -- Chapter 6. How to become a marine mammal scientist.
    Abstract: This highly-readable Open Access textbook provides basic background information about marine mammals and anthropogenic impacts on them. The book includes inspiring exercises for education school programs in natural sciences. The book also provides advice on career paths using case studies of marine scientists and veterinarians describing their journeys from student to profession. By sharing real-life career paths, readers find answers to questions such as “What needs to be considered when choosing a career in science?” and “What kind of tasks do scientists undertake on a daily basis?” Marine mammals are amongst some of the most celebrated creatures on Earth, with their high intelligence, social and communicating skills, and capacity for deep diving. Alongside general information about marine mammals, the book aims at generating awareness of the impact of litter and noise pollution on the marine environment using marine mammals as an example. Huge numbers of marine animals, including marine mammals, die every year from entanglement in fishing gear, by ingestion of litter or because of chemical pollution. In the last decade many technological and scientific tools have been developed to aid research, for instance miniaturised sound recorders which can be attached to cetaceans and seals and record noise levels around them, their vocal production as well as their diving behaviour. This Open Access textbook can be used by undergraduate students interested in the fundamentals of marine mammal biology and medicine, and in pursuing the profession of a marine scientist. .
    Type of Medium: Online Resource
    Pages: X, 95 p. 32 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031068362
    URL: https://doi.org/10.1007/978-3-031-06836-2
    DOI: 10.1007/978-3-031-06836-2
    DDC: 590
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    Neuroimmune Interactions in Pain : Mechanisms and Therapeutics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    URL: https://doi.org/10.1007/978-3-031-29231-6
    DOI: 10.1007/978-3-031-29231-6
    DDC: 612.8
    Language: English
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    Machine Learning and Deep Learning in Computational Toxicology (2023)
    Cham :Springer International Publishing :
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    Keywords: Toxicology. ; Machine learning. ; Artificial intelligence. ; Toxicology. ; Machine Learning. ; Artificial Intelligence.
    Description / Table of Contents: Machine Learning and Deep Learning Promotes Predictive Toxicology for Risk Assessment of Chemicals -- Multi-Modal Deep Learning Approaches for Molecular Toxicity prediction -- Emerging Machine Learning Techniques in Predicting Adverse Drug Reactions -- Drug Effect Deep Learner Based on Graphical Convolutional Network -- AOP Based Machine Learning for Toxicity Prediction -- Graph Kernel Learning for Predictive Toxicity Models -- Optimize and Strengthen Machine Learning Models Based on in vitro Assays with Mecha-nistic Knowledge and Real-World Data -- Multitask Learning for Quantitative Structure-Activity Relationships: A Tutorial -- Isalos Predictive Analytics Platform: Cheminformatics, Nanoinformatics and Data Mining Applications -- ED Profiler: Machine Learning Tool for Screening Potential Endocrine Disrupting Chemicals -- Quantitative Target-specific Toxicity Prediction Modeling (QTTPM): Coupling Machine Learning with Dynamic Protein-Ligand Interaction Descriptors (dyPLIDs) to Predict Androgen Receptor-mediated Toxicity -- Mold2 Descriptors Facilitate Development of Machine Learning and Deep Learning Models for Predicting Toxicity of Chemicals -- Applicability Domain Characterization for Machine Learning QSAR Models -- Controlling for Confounding in Complex Survey Machine Learning Models to Assess Drug Safety and Risk. .
    Abstract: This book is a collection of machine learning and deep learning algorithms, methods, architectures, and software tools that have been developed and widely applied in predictive toxicology. It compiles a set of recent applications using state-of-the-art machine learning and deep learning techniques in analysis of a variety of toxicological endpoint data. The contents illustrate those machine learning and deep learning algorithms, methods, and software tools and summarise the applications of machine learning and deep learning in predictive toxicology with informative text, figures, and tables that are contributed by the first tier of experts. One of the major features is the case studies of applications of machine learning and deep learning in toxicological research that serve as examples for readers to learn how to apply machine learning and deep learning techniques in predictive toxicology. This book is expected to provide a reference for practical applications of machine learning and deep learning in toxicological research. It is a useful guide for toxicologists, chemists, drug discovery and development researchers, regulatory scientists, government reviewers, and graduate students. The main benefit for the readers is understanding the widely used machine learning and deep learning techniques and gaining practical procedures for applying machine learning and deep learning in predictive toxicology. .
    Type of Medium: Online Resource
    Pages: XIX, 635 p. 149 illus., 124 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031207303
    Series Statement: Computational Methods in Engineering & the Sciences,
    URL: https://doi.org/10.1007/978-3-031-20730-3
    DOI: 10.1007/978-3-031-20730-3
    DDC: 615.90072
    Language: English
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    A Field Guide to Tropical Plant Families (2023)
    Cham :Springer International Publishing :
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    Keywords: Botany. ; Plant anatomy. ; Biodiversity. ; Plant Science. ; Plant Anatomy and Morphology. ; Biodiversity.
    Description / Table of Contents: Part I – User manual and architectural concepts. Chapter 1. Introduction -- Chapter 2. How to use this book 6 -- Chapter 3. Architectural concepts and key to the models -- Part II. Identification keys -- Chapter 4. Key to the groups of families of trees and shrubs (groups 1 to 52) -- Chapter 5. Keys to families of trees and shrubs -- Chapter 6. Supplementary keys -- Chapter 7. Keys to the groups of families of lianas and woody epiphytic (groups 53 to 57) -- Chapter 8. Keys to families of lianas and woody epiphytes -- PART III. Description of the families -- Chapter 9. Acanthaceae to Asteraceae -- Chapter 10. Bignoniaceae to Buxaceae -- Chapter 11. Cactaceae to Cycadaceae -- Chapter 12. Dichapetalaceae to Dipterocarpaceae -- Chapter 13. Ebenaceae to Euphorbiaceae -- Chapter 14. Fagaceae -- Chapter 15. Gentianaceae to Goupiaceae -- Chapter 16. Hamamelidaceae to Humiriaceae -- Chapter 17. Icacinaceae s.l. to Irvingiaceae -- Chapter 18. Juglandaceae -- Chapter 19. Lamiaceae to Lythraceae -- Chapter 20. Magnoliaceae to Myrtaceae -- Chapter 21. Nyctaginaceae,- Chapter 22. Ochnaceae to Oxalidaceae -- Chapter 23. Pandaceae to Putranjivaceae -- Chapter 24. Rhabdodendraceae to Rutaceae -- Chapter 25. Sabiaceae to Symplocaceae -- Chapter 26. Tetramelaceae to Torricelliaceae -- Chapter 27. Ulmaceae s.l. to Urticaceae -- Chapter 28. Verbenaceae to Vochysiaceae -- Chapter 29. Zygophyllaceae s.l -- Chapter 30. Herbaceous versus arborescent habit in the families and orders of flowering plants - evolutionary trends.
    Abstract: This book provides an identification system permitting recognition of plant families in all seasons by means of morphological and macroanatomical features which are easily observable, such as bark, exudates, stems and leaves characters. Studies of forest vegetation may differ in their underlying objectives, but they all require taxonomic knowledge. The process of taxonomy begins with an inventory of the flora, which has been based to a large extent on reproduction-related organs, such as flowers and fruits. But, those are often difficult to observe and may not exist in the field at a given time. Unlike most such guides or keys, this book can be used anywhere in the tropics and provides, in a straightforward two or three-step process, identification to the level of families, which are now circumscribed according to molecular as well as morphological characters in the universally accepted scheme of the Angiosperm Phylogeny Group. Plant architecture is not a prerequisite theme for plant identification; however, we think that an introduction to this subject is not out of place in this book (architectural traits are taxonomically sound): it is now time for botanists working in the tropics to have an idea on how the whole organism keeps growing. Within the family accounts, there is information concerning important economic plants with notes on the larger genera and, particularly helpfully, discussion of families readily confused and how to separate them. Descriptions of the families rely on short diagnosis bolstered by many photographic pictures, lines drawings and extracts from the author’s field books, all showing features of plants as they are found in the forest.
    Type of Medium: Online Resource
    Pages: XVII, 494 p. 909 illus., 850 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031059421
    URL: https://doi.org/10.1007/978-3-031-05942-1
    DOI: 10.1007/978-3-031-05942-1
    DDC: 580
    Language: English
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    Smart Livestock Nutrition (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Veterinary medicine. ; Agriculture. ; Physiology. ; Agricultural genome mapping. ; Animal welfare Moral and ethical aspects. ; Veterinary Science. ; Agriculture. ; Animal Physiology. ; Agricultural Genetics. ; Animal Ethics.
    Description / Table of Contents: Chapter 1. Putting Smart into Nutrition -- Chapter 2. Mozatching Feed Characteristics to Animal Requirements Through Plant Breeding -- Chapter 3. Circular Feed Production and Consumption in The Context Of Smart Animal Nutrition -- Chapter 4. Assessment of The Nutritive Value of Individual Feeds and Diets by Novel Technologies -- Chapter 5. Large Scale Phenotyping and Genotyping: State of The Art and Emerging Challenges -- Chapter 6. Mathematical and Statistical Approaches to The Challenge of Forecasting Animal Performance for The Purposes of Precision Livestock Feeding -- Chapter 7. Smart Pig Nutrition in the Digital Era -- Chapter 8. Smart Poultry Nutrition -- Chapter 9. Advanced Technology in Aquaculture – Smart Feeding in Marine Fish Farms -- 10. Smart Nutrition of Extensively Kept Ruminants -- Chapter 11. The Potential Contribution of Smart Animal Nutrition in Reducing The Environmental Impacts of Livestock Systems.
    Abstract: This book highlights the latest findings and techniques related to nutrition and feed efficiency in animal agriculture. It addresses the key challenges facing the nutrition industry to achieve high animal productivity with minimal environmental impact. The concept of smart nutrition involves the use of smart technologies in the feeding and management of livestock. The first chapters focus on advances in biological fields such as molecular agriculture and genotype selection, as well as technologies that enhance or enable the collection of relevant information. The next section highlights applications of smart nutrition in a variety of livestock systems, ranging from intensive indoor housing of broilers and pigs to extensive outdoor housing of cattle and sheep, and marine fish farms. Finally, because of the worldwide attention to this issue, the authors address the environmental consequences. This work, which takes a serious look at how nutrition can be used to improve sustainability in animal agriculture, is a key literature for readers in animal and veterinary sciences, the food industry, sustainability research, and agricultural engineering.
    Type of Medium: Online Resource
    Pages: VIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031225840
    Series Statement: Smart Animal Production, 1
    URL: https://doi.org/10.1007/978-3-031-22584-0
    DOI: 10.1007/978-3-031-22584-0
    DDC: 636.089
    Language: English
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    Baking Business Sustainability Through Life Cycle Management (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Food science. ; Sustainability. ; Family-owned business enterprises. ; Economics. ; Food Science. ; Sustainability. ; Family Business. ; Economics.
    Description / Table of Contents: Chapter 1 Bread Industry Sustainability Life Cycle Assessment -- Chapter 2 Product Environmental Footprint and Bread Industry -- Chapter 3 Life Cycle Assessment and Product Environmental Footprint - recommendations for integral optimization of economic and environmental performance -- Chapter 4 Ensuring sustainability of baking industry in North Macedonia -- Chapter 5 Sustainability approach of the baking industry along the food supply chain -- Chapter 6 Sustainability assessment of the baking industry complying with standards requirements: a case of Romania -- Chapter 7 Across American overview on sustainability approach throughout baking industry: An analytical-descriptive approach -- Chapter 8 Asian Overview on Sustainability Approach in Baking Industry -- Chapter 9 African Experience in Ensuring Sustainability in Baking -- Chapter 10 Indian experience in ensuring sustainability in baking industry -- Chapter 11 Measuring Baking Business Performance -- Chapter 12 Forming the efficient business model for bakery -- Chapter 13 Assessment of the sustainable competitiveness of agricultural enterprises on the grain market: case of Ukraine -- Chapter 14 Economic viability and sustainability in baking industry/ Simeuna - bread producer with own grain production -- Chapter 15 Impact of Bakery Innovation on Business Resilience Growth -- Chapter 16 Innovation in the commercial system of the small bakery industry -- New business models in food systems for farmers and companies, based on multi-actor approach -- Chapter 18 The role of rural women in bread industry – Job creation and retention in rural areas.
    Abstract: This timely and comprehensive text focuses on important recent advances in applied sustainability in the baking industry, connecting all of the current methods and strategies into a single book. Those involved in bread production will find the latest developments at the theoretical and practical levels, including information and communication requirements, reporting and regulatory aspects, economic and environmentally sustainable business models, supply chain management, life cycle assessment, product and organizational environmental footprints and more. For small bakery business owners to industry leaders and policymakers, governmental authorities, regulatory authorities and standardization bodies, this book offers a compilation of technical information about sustainability in the market for the bakery sector. Baking Business Sustainability Through Life Cycle Management begins by presenting basic information on the life cycle assessment and product environmental footprint of the bread industry, proposing an analysis of sustainability assessment using environmental and social footprints and providing recommendations for integral optimization of economic and environmental performance. A second section focuses on sustainability in the baking industry, providing a regional focus from Europe to the Americas to Africa and Asia. The third section takes a deep look at economic feasibility and efficiency in the bread industry, including the economic viability of different scenarios for bread-based value chains, and forming efficient business models for bakeries. A final section zeroes in on the most up-to-date innovations in the current bakery industry, including the impact of bakery innovation on business resilience growth, commercial systems, and new business models in regional food systems for farmers and companies, based on multi-actor approach. Innovations within the bakery industry are at an all-time high, with new sustainability and economic models being introduced, along with associated market risks. This timely and ambitious text aims to cover all the most recent advances and methods for successful incorporation into bakery businesses. .
    Type of Medium: Online Resource
    Pages: VIII, 313 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031250279
    URL: https://doi.org/10.1007/978-3-031-25027-9
    DOI: 10.1007/978-3-031-25027-9
    DDC: 641.3
    Language: English
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  • 50
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    Metabolism of Alimentary Compounds by the Intestinal Microbiota and Health (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Nutrition   . ; Medical microbiology. ; Human physiology. ; Medicine, Preventive. ; Health promotion. ; Nutrition. ; Medical Microbiology. ; Human Physiology. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Chapter 1. Physiological and Metabolic Functions of the Intestinal Epithelium: From the Small to the Large Intestine -- Chapter 2. Intestine Offers Board and Lodging for Intestinal Microbes on a Short- or Long-Term Stay -- Chapter 3. Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine -- Chapter 4. Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium -- Chapter 5. Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues’ Metabolism, Physiology, and Pathophysiology -- Chapter 6. Lessons to Be Learned from Clinical and Experimental Research on the Intestinal Microbiota Metabolic Activity for Health Benefit and Perspectives.
    Abstract: This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues. Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented. Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 57 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263224
    URL: https://doi.org/10.1007/978-3-031-26322-4
    DOI: 10.1007/978-3-031-26322-4
    DDC: 613.2
    Language: English
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    Engineering Translational Models of Lung Homeostasis and Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Regenerative medicine. ; Biomedical engineering. ; Cytology. ; Biomaterials. ; Cells. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering. ; Cell Biology. ; Biomaterials-Cells. ; Biotechnology. ; Biomaterials.
    Abstract: Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: X, 326 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031266256
    Series Statement: Advances in Experimental Medicine and Biology, 1413
    URL: https://doi.org/10.1007/978-3-031-26625-6
    DOI: 10.1007/978-3-031-26625-6
    DDC: 612.028
    Language: English
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    The Renin Angiotensin System in Cardiovascular Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    URL: https://doi.org/10.1007/978-3-031-14952-8
    DOI: 10.1007/978-3-031-14952-8
    DDC: 610.72
    Language: English
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    Social and Affective Neuroscience of Everyday Human Interaction : From Theory to Methodology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Description / Table of Contents: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Abstract: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Type of Medium: Online Resource
    Pages: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086519
    URL: https://doi.org/10.1007/978-3-031-08651-9
    DOI: 10.1007/978-3-031-08651-9
    DDC: 612.8
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    Careers in Food Science: From Undergraduate to Professional (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Food science. ; Chemistry. ; Food Science. ; Chemistry.
    Description / Table of Contents: Section 1: Introduction -- 1. Introduction: Career Preparation for the Food & Beverage Industry -- 2. The Equilibrium of Life-Career Planning -- 3. First Jobs for Food Science -- Section 2: The undergraduate student experience -- 4. Making the Most of Your Undergraduate Experience -- 5. Campus Career Services and Centers -- 6. Professionalism and Leadership -- 7. Is Food Science Right For Me? The Transfer Experience -- 8. The Decision to Pursue an Internship -- 9. IFT Student Association -- Section 3: A successful industry career -- 10. Finding and negotiating a job -- 11. Employer expectations/Managing corporate life -- 12. Could a small company be for you? -- 13. A successful industry career or Making your way in a company -- Section 4: Careers with a degree in food science -- 14. Quality -- 15. Production management -- 16. Product development -- 17. Technical sales -- 18. R&D -- 19. Regulatory and food law -- 20. Careers in Traceability -- 21. Using food science in special interest groups -- 22. Food for Good: Leveraging Food Science to Feed the World -- 23. Careers that combine Culinary and Food Science -- 24. Entrepreneurship and Consulting: Taking a Different Path -- 25. Careers in Sensory Science -- 26. Food Science in Community-Based Food Systems -- 27. Working for a Startup Company -- 28. Careers in Sustainability -- 29. A Career in Management -- Section 5: The graduate student experience -- 30. Is grad school right for me? -- 31. Finding and getting into the right grad program -- 32. The transition from undergraduate to graduate student -- 33. Faculty expectations of graduate students.
    Abstract: Careers in Food Science provides detailed guidelines for students and new employees in the food industry to ensure a successful start to their career. Every step towards a rewarding career in this rapidly evolving industry is covered, from which classes to take in college and which degrees to earn, to internships, and finally how to land, and keep, the first job. This book also provides day-to-day examples of what to expect from the many jobs available to help students decide what to do and where to go. This second edition includes nine new chapters covering research chefs, food systems, social justice, food waste, start-ups, sustainability, and management. Several new authors offer fresh perspectives. Provides detailed guidelines for students as well as new employees in food industry; Includes perspectives from school years through how to succeed at new job; Written by individuals who have just gone through that experience or who are working in that particular sector.
    Type of Medium: Online Resource
    Pages: XII, 411 p. 5 illus., 1 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031143533
    URL: https://doi.org/10.1007/978-3-031-14353-3
    DOI: 10.1007/978-3-031-14353-3
    DDC: 641.3
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    Emerging Nanomaterials : Opportunities and Challenges in Forestry Sectors (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Nanotechnology. ; Botany. ; Biotechnology. ; Anatomy. ; Genetics. ; Forestry. ; Nanotechnology. ; Plant Science. ; Biotechnology. ; Anatomy. ; Genetics and Genomics.
    Description / Table of Contents: Preface -- Chapter. 1. Emerging nanomaterials for forestry and associated sectors: An overview -- Chapter. 2. Potential of Nanomaterials in Bio-Based Wood Adhesives: An Overview -- Chapter. 3. Nanomaterials to improve fire properties in wood and wood-based composite panels -- Chapter. 4. Wood Plastic Composites (WPC): Applications of Nanomaterials -- Chapter. 5. Nanomaterials to improve properties in wood-based composite panels -- Chapter. 6. Nanomaterials to improve the strength of wooden joints -- Chapter. 7. Application of nanomaterials for wood protection -- Chapter. 8. Nanocellulose in paper and board coating -- Chapter. 9. Green Materials for Radiation Shielding: An overview -- Chapter. 10. Formaldehyde emissions from wood-based composites: Effects of nanomaterials.
    Abstract: Bio-based materials, including those containing wood, will become increasingly important as we move to a bio-based economy. Among their many attributes, it is vitally important that these materials are renewable, sustainable with proper management and environmentally benign. Wood remains one of our most important bio-based materials. While it is an amazing material, wood still has negative attributes and drawbacks that can affect performance, including dimensional instability when wetted, vulnerability to fire and high temperatures, and susceptibility to biodeterioration. A variety of treatments have been developed to overcome these weaknesses. Among the most exciting of these treatments are nanomaterials. These materials have some exceptionally attractive properties for improving timber performance and have been the subject of intensive research over the past decade. There is a tremendous need for a single comprehensive source of information on this rapidly emerging subject with tremendous potential to enhance the performance of a variety of bio-based materials. This book contains 10 chapters, each compiled by different author(s) who are considered the top researcher(s) in their respective fields. The chapters begin with some basic background on nanomaterials and their synthesis, then explore different areas for potential applications and conclude with a review of the emerging questions about nanomaterial safety. The book is designed to provide the latest information and know-how on application and utilization of different nanomaterials to improve the properties of wood and wood-based composite panels. The contents cover some main topics in the industry including improving physical and mechanical properties, increasing resistance to biodegradation (including fungi and insects), developing wood-plastic composites (WPC), applying nanomaterials in paper and board industry, and emergence of transparent wood and radiation shielding. It also covers the use of nanomaterials to improve the performance of paints and finishes used for forest products. The book provides a single location for those interested in the field to begin.
    Type of Medium: Online Resource
    Pages: X, 362 p. 85 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173783
    URL: https://doi.org/10.1007/978-3-031-17378-3
    DOI: 10.1007/978-3-031-17378-3
    DDC: 634.9
    Language: English
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    Plant Relationships : Fungal-Plant Interactions (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Plant diseases. ; Microbial genetics. ; Plant physiology. ; Fungi. ; Mycology. ; Plants. ; Microbiology. ; Plant Pathology. ; Microbial Genetics. ; Plant Physiology. ; Fungi. ; Plant Signalling.
    Description / Table of Contents: Part I. Pathogenic Fungus – Plant Interactions -- Modulation of Host Immunity and Development by Ustilago Maydis -- RNA Dialogues in Fungal-Plant Relationships -- The Role of Tox Effector Proteins in the Parastagonospora Nodorum-Wheat Interaction -- Part II. Mutualistic Fungus – Plant Interactions -- Genomes of Arbuscular Mycorrhizal Fungi -- Diversity of Seed Endophytes: Causes and Implications -- Lichens and Their Allies Past and Present -- Lichen Fungal Secondary Metabolites: Progress in the Genomic Era Towards Ecological Roles in the Interaction -- Part III. Sensing and Signalling in Fungus-Plant Interactions -- Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens -- Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity -- Role of Volatile Organic Compounds in Establishment of the Trichoderma-Plant Interaction -- Part IV. Regulation of Fungal Gene Expression and Development -- Epigenetic Regulation of Fungal Genes Involved in Plant Colonization -- Toward Understanding the Role of Chromatin in Secondary Metabolite Gene Regulation in the Rice Pathogen Fusarium Fujikuroi -- The Rice Blast Fungus Magnaporthe Oryzae Uses a Turgor-Dependent, Septin-Mediated Mechanism to Invade Rice -- Role of Light in the Life Cycle of Botrytis Cinerea -- Part V. Genomes and Evolution -- Species of Zymoseptoria (Dothideomycetes) as a Model System to Study Plant Pathogen Genome Evolution -- Accessory Chromosomes of the Fusarium Oxysporum Species Complex and Their Contribution to Host Niche Adaptation -- Part VI. Global Pandemics and Food Security -- Global Landscape of Rust Epidemics by Puccinia Species: Current and Future Perspectives -- Magnaporthe oryzae and Its Pathotypes: A Potential Plant Pandemic Threat to Global Food Security.
    Abstract: This fully revised 3rd edition provides a comprehensive overview of the biology of fungi associated with plants. Since the publication of the 2nd Edition in 2009, tremendous new knowledge has been gained in the field of fungal-plant interactions, which is reflected in the contributions of this book. World-leading scientists in the field provide authoritative insights into fungal-plant interactions covering the following main topics: Mutualistic and pathogenic fungal-plant interactions in natural and agricultural ecosystems Sensing and signalling in fungus-plant interactions Regulation of fungal gene expression and development Fungal genomes and evolution Global pandemics caused by fungal pathogens and their implications for food security This volume will be of great interest to both specialists and generalists. It is an indispensable resource for researchers, lecturers and students in microbiology, mycology, and plant sciences, as well as agriculture and biotechnology.
    Type of Medium: Online Resource
    Pages: XXII, 462 p. 70 illus., 62 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031165030
    Series Statement: The Mycota, A Comprehensive Treatise on Fungi as Experimental Systems for Basic and Applied Research, 5
    URL: https://doi.org/10.1007/978-3-031-16503-0
    DOI: 10.1007/978-3-031-16503-0
    DDC: 579
    Language: English
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    The Basics of Molecular Biology (2023)
    Cham :Springer International Publishing :
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    Keywords: Molecular biology. ; Cytology. ; Genetics. ; Virology. ; Cancer. ; Enzymology. ; Molecular Biology. ; Cell Biology. ; Genetics. ; Virology. ; Cancer Biology. ; Enzymology.
    Description / Table of Contents: Introduction -- The major processes in the biological world -- Enzymes, conformational changes, energy, and molecular motors -- The cells -- Genome -- Regulation of gene expression and protein activity -- DNA replication, its fidelity, mutations, and repair -- Transduction of signals -- Multicellular organisms and their development -- Biological defense I. Protection from foreign nucleic acids -- Biological defense II. The immune system of vertebrates -- Pathogens -- Cancer -- Index.
    Abstract: Accessible and comprehensive, this book describes the universal cellular nature of living organisms and is an indispensable tool for anyone in the sciences who wishes to get a quick overview of molecular biology. Individual chapters cover nucleic acids and proteins, genetic code and protein synthesis, the fidelity of transferring genetic information to the next generations, and the regulation of various processes inside the cells. Special attention is paid to new areas rising from modern DNA sequencing technologies which transform biology. The book also touches on developing areas, such as cures for cancer and CRISPR, which are important for medicine and the future of humankind. .
    Type of Medium: Online Resource
    Pages: XIV, 184 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194047
    URL: https://doi.org/10.1007/978-3-031-19404-7
    DOI: 10.1007/978-3-031-19404-7
    DDC: 572
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    Matrix Pathobiology and Angiogenesis (2023)
    Cham :Springer International Publishing :
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    Keywords: Blood-vessels Growth. ; Cytology. ; Clinical biochemistry. ; Angiogenesis. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Fibronectin Fibrillogenesis during Angiogenesis -- Chapter 2: Functional Interplay Between Fibronectin and Matricellular Proteins in the Control of Endothelial Tubulogenesis -- Chapter 3: Endothelial Cell-Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors -- Chapter 4: Collagens and collagen-degrading enzymes in the regulation of angiogenesis -- Chapter 5: Kruppel-like factor 2 and matrix metalloproteinases in the context of vasculature -- Chapter 6: Extracellular Matrix-Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds -- Chapter 7: Cell - extracellular matrix adhesions in vascular endothelium -- Chapter 8: Hypoxia: a potent regulator of angiogenesis through extracellular matrix remodeling -- Chapter 9: Leading roles of heparan sulfate in angiogenesis and cancer -- Chapter 10: The role of pericytes in tumor angiogenesis -- Chapter 11: Lymphatic Mechanoregulation in Development and Disease.
    Abstract: In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: XXVII, 320 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031196164
    Series Statement: Biology of Extracellular Matrix, 12
    URL: https://doi.org/10.1007/978-3-031-19616-4
    DOI: 10.1007/978-3-031-19616-4
    DDC: 571.8
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    Advances in Research on Vegetable Production Under a Changing Climate Vol. 2 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Agriculture. ; Environment. ; Plant genetics. ; Agriculture. ; Environmental Sciences. ; Plant Genetics.
    Description / Table of Contents: Chapter 1 Advances in research trends in vegetables under a changing climate: A way forward -- Chapter 2 Emerging obstacles of vegetable production due to climate change and mitigation strategies -- Chapter 3 Impact of climate change on nutraceutical properties of vegetables -- Chapter 4 Nutritional stress management in vegetable crops under changing climate scenario -- Chapter 5 Impact of climate change on tuber crops production and mitigation strategies -- Chapter 6 Impact of climate change on leafy vegetables and mitigation strategies -- Chapter 7 Impact of climate change on perennial vegetable production and mitigation strategies -- Chapter 8 Impact of climate change on vegetables seed production and mitigation strategies -- Chapter 9 Protected cultivation of high-value vegetables crop under changing climate -- Chapter 10 Impact of climate change on underexploited vegetable crops production and mitigation strategies -- Chapter 11 Improvement of vegetables through grafting techniques in changing climate scenario -- Chapter 12 Improvement of vegetables through molecular breeding in changing climate scenario -- Chapter 13 Kitchen gardening for nutritional security under changing climate -- Chapter 14 Emerging insect-pests of vegetables due to changing climate -- Chapter 15 Emerging diseases of vegetables due to changing climate -- Chapter 16 Impact of climate change on postharvest quality of vegetables.
    Abstract: This second volume on the topic will be extremely useful for the researchers and postgraduate students working on vegetable crops with a special focus on climate change. Today, the entire world is suffering from global warming and its consequent, climate change. This has emerged as the most prominent global environmental issue and there is an urgent need to mitigate its impact on agriculture. Over the past 20 years South Asia has had a robust economic growth, yet it is home to more than one fourth of the world’s hunger and 40% of the world’s malnourished children and women. Persistent climatic variability, which results in frequent drought and flood, is among the major reasons for this phenomenon. Vegetables are in general more succulent (have 90% water) and more sensitive to climatic vagaries and sudden changes in temperature, as well as irregular precipitation at any phase of crop growing, can affect the normal growth, flowering, pollination, fruit setting, fruit development and fruit ripening which eventually decreases the yield. The irregular precipitation also causes the soil salinity and is a major challenge in many vegetable growing areas. To mitigate the harmful impact of climatic change there is an urgent need to develop adequate adaptation strategies for adverse effect of climate change and preference should be given to the development of heat, cold, drought, flood and salinity stress tolerant genotypes along with climate proofing through conventional and non-conventional breeding techniques, as well as exploiting the beneficial effects of CO2 enhancement on crop growth and yield. Available evidence shows that there is high probability of increase in the frequency and intensity of climate related natural hazards due to climate change and hence increase the potential threat due to climate change related natural disasters in the world. At present protected cultivation and grafted seedlings are also popularizing among vegetable growers because of the huge scope as well as, molecular breeding, emerging insect-pests & diseases and postharvest quality of vegetables under this climate change scenario. Moreover, underexploited vegetables, perennial vegetable and tuber crops have a more tolerant ability to climate vagaries compare to major vegetables which are also discussed in this book.
    Type of Medium: Online Resource
    Pages: XVII, 369 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031208409
    Series Statement: Advances in Olericulture,
    URL: https://doi.org/10.1007/978-3-031-20840-9
    DOI: 10.1007/978-3-031-20840-9
    DDC: 630
    Language: English
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    Priority-Zone Mapping for Reforestation : Case Study in the Montane Dry Forests of Bolivia (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Environmental management. ; Geographic information systems. ; Sustainability. ; Forestry. ; Environmental Management. ; Geographical Information System. ; Sustainability.
    Abstract: Andean dry forest ecosystems are threatened by deforestation and unsustainable land use methods. The negative effects for the livelihood of the local population, biodiversity, and the regional climate could be countered by reforestation measures; however, dry land forests have not attracted the same level of interest and investment like other ecosystems. This book describes the development of a priority-zone map for reforestation measures, showing where reforestation might have the greatest social and ecological benefits. To achieve this, a problem analysis of a case study region is conducted and thematic reforestation benefits are determined. Using remote sensing and GIS, the areas where benefits can be obtained are mapped in individual layers and compiled into a summarizing priority-zone map. It is thus possible to identify areas where reforestation would achieve multiple benefits. The concept of priority maps could be used to facilitate reforestation strategies by local communities and municipal governments and could thus contribute to initiate an integrated forest and landscape restoration of the Bolivian montane dry forests.
    Type of Medium: Online Resource
    Pages: XVII, 97 p. 42 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031203756
    Series Statement: SpringerBriefs in Geography,
    URL: https://doi.org/10.1007/978-3-031-20375-6
    DOI: 10.1007/978-3-031-20375-6
    DDC: 634.9
    Language: English
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    History of Arbovirology: Memories from the Field : Volume I: Personal Reflections (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    URL: https://doi.org/10.1007/978-3-031-21999-3
    DOI: 10.1007/978-3-031-21999-3
    DDC: 579.2
    Language: English
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    Multispecies Biofilms : Technologically Advanced Methods to Study Microbial Communities (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biofilms. ; Microbial populations. ; Bacteria. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Biofilms. ; Microbial Communities. ; Bacteria. ; Fungi. ; Medical Microbiology.
    Description / Table of Contents: 3M’s of Multi-Species Biofilms: Microbial Pathogens, Microenvironments and Minimalist Laboratory Approaches to Study Multi-Species Biofilms under Microenvironmental Conditions -- Methods for the visualization of multispecies biofilms -- In vitro, in vivo and ex vivo models to study mixed bacterial and fungal biofilms -- Current and emerging in vitro and in vivo biofilm models in investigating fungal-bacterial polymicrobial communities: Fungal-bacterial biofilm models -- Involvement of bacterial outer membrane vesicles in cell-cell interactions and their role in multi-species communities -- Polymicrobial biofilm models: the case of periodontal disease as an example -- Polymicrobial biofilms in cystic fibrosis lung infections: effects on antimicrobial susceptibility -- High resolution methods to study microbial interactions in biofilms -- Unity in Diversity: Interkingdom Polymicrobial Biofilms in Disease.
    Abstract: In an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context. This book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the book highlights new technologies built and designed for the study of multiple species within biofilm communities, including those that can be leveraged for the evaluation of antimicrobial treatment approaches. The application of these state-of-the-art techniques to further our understanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools. With cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students. .
    Type of Medium: Online Resource
    Pages: VI, 321 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153495
    Series Statement: Springer Series on Biofilms, 12
    URL: https://doi.org/10.1007/978-3-031-15349-5
    DOI: 10.1007/978-3-031-15349-5
    DDC: 579.17
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    Pharmacoresistance in Epilepsy : From Genes and Molecules to Promising Therapies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Abstract: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Type of Medium: Online Resource
    Pages: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031365263
    URL: https://doi.org/10.1007/978-3-031-36526-3
    DOI: 10.1007/978-3-031-36526-3
    DDC: 612.8
    Language: English
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    Therapeutic Applications of Dopamine D3 Receptor Function : New Insight After 30 Years Of Research (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    URL: https://doi.org/10.1007/978-3-031-23058-5
    DOI: 10.1007/978-3-031-23058-5
    DDC: 615
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    Biomedical Visualisation : Volume 14 ‒ COVID-19 Technology and Visualisation Adaptations for Biomedical Teaching (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    URL: https://doi.org/10.1007/978-3-031-17135-2
    DOI: 10.1007/978-3-031-17135-2
    DDC: 610.72
    Language: English
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    Dose Optimization in Digital Radiography and Computed Tomography : An Essential Guide (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Radiation dosimetry. ; Radiology. ; Radiography, Medical. ; Nuclear medicine. ; Radiation Dosimetry and Protection . ; Radiology. ; Radiography. ; Nuclear Medicine.
    Description / Table of Contents: Dose Optimization: A Useful Tool in Radiation Protection -- Digital Radiography: A Technical Review -- Optimization Strategies in Digital Radiography -- Computed Tomography: A Technical Review.
    Abstract: This book addresses radiation protection of patients having digital radiography and computed tomography (CT) examinations. The literature on radiation doses to patients from these two modalities have reported that the doses to patients are high. As a result, the radiology community has focused on methods and procedures to keep these doses as low as reasonably achievable (ALARA) without compromising the diagnostic image quality. This book outlines the motivation for dose optimization in radiology, identifies and describes the ICRP principle of optimization, outlines the factors affecting the dose in digital radiography and in CT, and identifies and describes strategies used in digital radiography and in CT for dose optimization. This book is intended for all those working in digital radiography and CT environments including radiological technologists, and radiographers, radiologists, biomedical engineering technologists, and student medical physicists. It is best used as a supplement to radiologic science textbooks, and in particular, radiation protection textbooks. Furthermore, this book lays the foundations for students and practitioners engaged in research on dose reduction and dose optimization in radiology.
    Type of Medium: Online Resource
    Pages: XIII, 102 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031228711
    URL: https://doi.org/10.1007/978-3-031-22871-1
    DOI: 10.1007/978-3-031-22871-1
    DDC: 571.45
    Language: English
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    Development of the Cerebellum from Molecular Aspects to Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Description / Table of Contents: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Abstract: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Type of Medium: Online Resource
    Pages: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031231049
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-23104-9
    DOI: 10.1007/978-3-031-23104-9
    DDC: 612.8
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    The Flax Genome (2023)
    Cham :Springer International Publishing :
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    Keywords: Botany. ; Genetics. ; Biotechnology. ; Plant Science. ; Genetics and Genomics. ; Biotechnology.
    Description / Table of Contents: Reference genome sequence of flax -- Repeat DNA sequences in flax genomes -- Pale flax (Linum bienne): an underexplored flax wild relative -- Flax breeding -- QTL mapping: strategy, progress and prospects in flax -- Genetics of abiotic stress in flax. QTL and candidate genes for flax disease resistance -- Key stages of flax bast fiber development through the prism of transcriptomics -- Metabolomics and transcriptomics-based tools for linseed improvement.
    Abstract: The Flax Genome is a comprehensive compilation of most recent studies focused on reference genome, genetic resources and molecular diversity, breeding, QTL mapping, gene editing tools, functional genomics and metabolomics, molecular breeding via genomic selection, and genomic resources. The flax genome reference sequences and the new genome assemblies are presented. A list of flax QTL and candidate genes associated with more than 35 traits, including yield and agronomic, seed quality and fatty acid composition, fibre quality and yield, abiotic stress, and disease resistance traits, are summarized. A QTL- based genomic selection strategy and genome–editing tools are systematically introduced. In addition, huge amounts of flax genomic resources generated in the last decade are summarized. The book contains 13 chapters with about 390 pages authored by globally reputed researchers in the relevant fields to this crop The book is intended to be useful to students, teachers, and researchers interested in traditional and molecular breeding, pathology, molecular genetics and breeding, bioinformatics and computational biology, and functional genomics.
    Type of Medium: Online Resource
    Pages: XII, 294 p. 74 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031160615
    Series Statement: Compendium of Plant Genomes,
    URL: https://doi.org/10.1007/978-3-031-16061-5
    DOI: 10.1007/978-3-031-16061-5
    DDC: 580
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    Malarial Drug Delivery Systems : Advances in Treatment of Infectious Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Drug delivery systems. ; Nanobiotechnology. ; Pharmaceutical chemistry. ; Tropical medicine. ; Pharmacology. ; Medical microbiology. ; Drug Delivery. ; Nanobiotechnology. ; Pharmaceutics. ; Tropical Medicine. ; Pharmacology. ; Medical Microbiology.
    Description / Table of Contents: Malaria: Cellular Understanding of Disease -- Drug Resistance, Statistics and Patent Status -- Malaria: Current Treatment Options -- Polymeric Nanoparticles in Malaria -- Solid Lipid Nanoparticles in Malaria -- Dendrimers in Malaria -- Liposomes in Malaria -- Micro and Nano Emulsions in Malaria -- Nanosuspension in Malaria -- Alginate and Gelatin Nanoparticles in Malaria -- Niosomes in Malaria -- Metal Nanoparticles in Malaria -- Nanotechnology in Malaria Diagnosis -- Nanotechnology-based Vaccination -- Herbal Platforms in Malaria -- Surface-modified Drug Delivery Systems in Malaria,- Clinical Trials in Malaria -- Malaria-Overall Picture -- New Drugs in Synthesis Research for Malaria -- Disease Models In Malaria Research.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause of significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at the cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The theme of the first book is Malaria. This book compiles the complete road map of malarial drug delivery systems by understanding the pathophysiology of the disease, the current state of malaria across the globe, new clinical trials, emerging drugs, and the development of novel drug delivery platforms. Various novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of malarial research.
    Type of Medium: Online Resource
    Pages: X, 395 p. 55 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031158483
    URL: https://doi.org/10.1007/978-3-031-15848-3
    DOI: 10.1007/978-3-031-15848-3
    DDC: 615.6
    Language: English
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    Health and Welfare of Captive Reptiles (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Veterinary medicine. ; Physiology. ; Animal welfare Moral and ethical aspects. ; Ecology . ; Zoology. ; Veterinary Science. ; Animal Physiology. ; Animal Ethics. ; Ecology. ; Zoology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Physiology and Functional Anatomy -- Chapter 3. Sensory Systems -- Chapter 4. Biology of Stress -- Chapter 5. Normal Behaviour -- Chapter 6. Social Behaviour as a Challenge for Welfare -- Chapter 7. Brains, Behaviour, and Cognition: Multiple Misconceptions -- Chapter 8. Psychological and Behavioural Principles and Problems -- Chapter 9. Effects of Ontogeny, Rearing Conditions, and Individual Differences on Behaviour: Welfare, Conservation, and Invasive Species Implications -- Chapter 10. Controlled Deprivation and Enrichment -- Chapter 11. Effects of Noise and Light -- Chapter 12. Ethologically Informed Design and DEEP Ethology in Theory and Practice -- Chapter 13. Spatial and Thermal Factors -- Chapter 14. Nutritional Considerations -- Chapter 15. Naturalistic Versus Unnaturalistic Environments -- Chapter 16. Evidential Thresholds for Species Suitability in Captivity -- Chapter 17. Record Keeping as an Aid to Captive Care -- Chapter 18. Arbitrary Husbandry Practices and Misconceptions -- Chapter 19. Miscellaneous Factors.
    Abstract: This extensively revised and expanded new edition offers concepts, principles and applied information that relates to the wellbeing of reptiles. As a manual on health and welfare in a similar vein to volumes addressing the sciences of anatomy, behaviour or psychology, this book thoroughly examines the biology of reptile welfare and is about meeting biological needs. The editors, acknowledged experts in their own right, have once again drawn together an extremely impressive international group of contributors. Positive and negative implications of general husbandry and research programs are discussed. In addition to greatly revised original content are nine new chapters offering readers novel insight into: • sensory systems • social behaviour • brain and cognition • controlled deprivation and enrichment • effects of captivity-imposed noise and light disturbance on welfare • spatial and thermal factors • evidential thresholds for species suitability in captivity • record keeping as an aid to captive care • arbitrary husbandry practices and misconceptions The authors have adopted a user-friendly writing style to accommodate a broad readership. Although primarily aimed at academic professionals, this comprehensive volume is fundamentally a biology book that will also inform all involved in captive reptile husbandry. Among others, zoo personnel, herpetologists, veterinarians, lab animal scientists, and expert readers in animal welfare and behavioural studies will benefit from this updated work.
    Type of Medium: Online Resource
    Pages: XI, 638 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030860127
    URL: https://doi.org/10.1007/978-3-030-86012-7
    DOI: 10.1007/978-3-030-86012-7
    DDC: 636.089
    Language: English
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    Garden Plants Taxonomy : Volume 2: Angiosperms (Eudicots) (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant anatomy. ; Plant physiology. ; Landscape architecture. ; Plant diseases. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Physiology. ; Landscape Architecture. ; Plant Pathology. ; Agriculture.
    Description / Table of Contents: Part-Dicotyledons -- 1. Basal Lineages -- 2. Magnoliids -- 3. Eudicots -- Index.
    Abstract: Horticulture has remained far behind in understanding of botanical principles. Recent phylogenetic (DNA-based) reorganization of higher plants has revolutionized taxonomic treatments of all biological entities, even when morphology does not completely agree with their organization. This book is an example of applying principals of botanical phylogenetic taxonomy to assemble genera, species, and cultivars of 200 vascular plant families of ferns, gymnosperms, and angiosperms that are cultivated for enhancement of human living space; homes, gardens, and parks. The emphases are on cultivated species but examples of some plants are often shown in the wild and in landscapes. In providing descriptions, it is assumed that students and other interested individuals have no background in general botany (plant characteristics), or nomenclature. Fundamental features of all plant groups discussed are fully illustrated by original watercolor drawings or photographs. Discussion of the families is grounded on recent botanical phylogenetic treatments, which is based on common ancestry (monophyly). Of course, phylogenetic taxonomy is not a new concept, and was originally based on morphological characteristics; it is the DNA-based phylogeny that has revolutionized modern biological classifications. In practical terms, this book represents the horticultural treatment that corresponds to phylogenetic-based botanical taxonomy, to which is added cultigens and cultivated genera and species. Hence, the harmony between horticultural and botanical taxonomy. This book covers phylogenetic-based taxonomy of Angiosperms (Eudicots). A companion volume covers Ferns, Gymnosperms, and Angiosperms (Monocots).
    Type of Medium: Online Resource
    Pages: XXXV, 1493 p. 1326 illus., 1325 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115653
    URL: https://doi.org/10.1007/978-3-031-11565-3
    DOI: 10.1007/978-3-031-11565-3
    DDC: 571.32
    Language: English
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    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
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    Regulatory Aspects of Gene Therapy and Cell Therapy Products : A Global Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Medical genetics. ; Genetics. ; Cell Biology. ; Medical Genetics. ; Clinical Genetics. ; Genetics.
    Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .
    Abstract: This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
    Type of Medium: Online Resource
    Pages: IX, 242 p. 37 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031345678
    Series Statement: Advances in Experimental Medicine and Biology, 1430
    URL: https://doi.org/10.1007/978-3-031-34567-8
    DOI: 10.1007/978-3-031-34567-8
    DDC: 571.6
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    Tubercular Drug Delivery Systems : Advances in Treatment of Infectious Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Drug delivery systems. ; Diseases. ; Pharmaceutical chemistry. ; Nanomedicine. ; Drug Delivery. ; Diseases. ; Pharmaceutics. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Global health and Tuberculosis past, present and Future -- Tuberculosis: cellular understanding of disease.-Metal nanoparticles in TB -- TB: current treatment options -- Polymeric nanoparticles in TB -- Solid lipid nanoparticles in TB -- Dendrimers in TB -- Liposomes in TB -- Micro, nano emulsions in TB -- Nano suspension in TB -- Alginate, gelatin nanoparticles in TB -- Niosome in TB -- Surface modified drug delivery systems in TB -- Clinical trials in TB -- Herbal platforms in TB.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the microorganisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious diseases. • Malarial drug delivery systems • Tubercular drug delivery systems • Viral drug delivery systems • Infectious disease drug delivery systems The theme of the second book is Tuberculosis (TB). This book addresses the recent trends in drug delivery for treating TB using new formulation technologies, and the mechanism how it can prevent or delay the drug resistance. It covers current drug therapy and new drug targeting approaches focusing on innovative trend-defining technologies and drug delivery platforms. It is essential to understand the relationship between host pathogens for better treatment. Various novel and nano-formulations using promising technologies are being explored to deliver TB drugs via different administration routes at right pathological site. This book addresses the gap between new and old treatment TB modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of TB research.
    Type of Medium: Online Resource
    Pages: X, 337 p. 51 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031141003
    URL: https://doi.org/10.1007/978-3-031-14100-3
    DOI: 10.1007/978-3-031-14100-3
    DDC: 615.6
    Language: English
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    Hereditary Gastric and Breast Cancer Syndrome : CDH1: One Genotype with Multiple Phenotypes (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer Genetic aspects. ; Cancer Treatment. ; Cancer. ; Medical screening. ; Oncology. ; Cancer Genetics and Genomics. ; Cancer Therapy. ; Cancer Screening. ; Oncology.
    Description / Table of Contents: Part I. Epidemiology -- Family History and the Risk of Breast and Gastric Cancer -- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis -- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome -- Part II. Genetics -- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes -- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes -- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants -- Other Syndromes and Genes Associated with Gastric Cancer Predisposition -- Computer-Assisted Interpretation of Cancer-Predisposing Variants -- Part III. Pathology -- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling -- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations -- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers -- Part IV. Endoscopy and Imaging -- Endoscopy: Is there Anything New? -- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families -- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon -- Part V. Surgery -- Prophylactic Total Gastrectomy: Techniques -- Prophylactic Total Gastrectomy: How Many? -- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery -- Breast Reconstruction -- Part VI. New Issues -- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis -- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives -- The Chemoprevention of Hereditary Diffuse Gastric Cancer -- Malformations and Malformative Syndromes Associated with CDH1 -- Hereditary Breast Cancer Non-CDH1 Associated -- Part VII. Patient Advocacy -- My Hereditary Gastric Cancer -- Hereditary Breast Cancer Syndrome, My Experience -- Part VIII. Miscellaneous -- β-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.
    Abstract: In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
    Type of Medium: Online Resource
    Pages: XV, 422 p. 58 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031213175
    URL: https://doi.org/10.1007/978-3-031-21317-5
    DOI: 10.1007/978-3-031-21317-5
    DDC: 576.5
    Language: English
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    Nanotoxicology in Nanobiomedicine (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Toxicology. ; Nanomedicine. ; Nanobiotechnology. ; Toxicology. ; Nanomedicine and Nanotoxicology. ; Medical Toxicology. ; Nanobiotechnology.
    Description / Table of Contents: Introduction -- Terminology -- nano -- polymer nanoparticles -- Nonpolymer nanoparticles -- Nanodevices -- Hybrid materials -- Nanocomposite -- Biomedical -- Further Reading -- Historical Development and Future Trends -- introduction -- Early Period -- Premodern period -- Middle Ages -- Modern Nanotechnology -- Regulations.-Scientific Trends -- Future Trends.-Small Systems Big Applications -- Smart Pills -- Beating the Big C -- Further Reading -- Sources and Classifications -- Introduction -- Properties -- Nanomaterials and Bulk Materials -- Sources -- Naturally produced -- Incidental -- Engineered Nanomaterials.-Classifications -- Natural NPs/NMs -- Incidental NPs -- Synthetic (Engineered) Nanomaterials (NMS) -- Dimensions Based Nanomaterials -- Nanoparticles -- Nanoclays -- nanoemulsions -- Further Reading -- Synthesis, Detection and Characterization -- Introduction -- Production Approaches -- Synthesis -- Physical Methods -- Chemical Methods -- Biological Approach -- magnetic nps -- Hybrid nanomaterials -- nanocomposites.-Detection -- Characterization and isolation -- Direct Techniques -- indirect Techniques -- Key Issues in Fabrication -- Further Reading -- Mechanisms of Nanotoxicty -- introduction -- Entry Sites and Uptake -- Elimination -- Phagocytosis -- Macropinocytosis -- Other Entry Mechanisms -- Intracellular Trafficking -- Trojan Horse Mechanism -- Cellular Exocytosis -- Cellular Dysfunction -- Inorganic Nanomaterial Toxicity -- Cell Deaths -- Further Readings -- Applications-. Introduction -- Nanoparticle-Based Technologies-. Agriculture -- Energy and Environment -- Materials Science and Engineering -- Materials Science and Engineering -- Health and Medicine -- Hybrid Nanomaterials -- Nanocomposites -- Further Reading -- Nano Based Drug Delivery Systems -- Introduction -- Overview in Biomedical Science -- properties of NP Drug Delivery -- Factors influencing Drug Laden Nanocarriers -- pH Specificity -- Temperature Specificity -- Temperature Specificity -- Advantages of Delivery Vehicles -- Nanocarriers -- Passive Targeting -- Active Targeting -- Uses and Applications -- Delivery Vehicles -- Organic Nanomaterials.-Poly-alkyl-cyano-acrylates (PAC) -- Artificial DNA Nanostructures -- Nanocomposites -- Hybrid nanoparticles -- Further Reading.-Tissue Engineering in Dentistry -- Introduction -- Materials for Dental Applications -- Structure and Periodontal Tissue -- Factors Affecting Bone Tissue Regeneration -- Periodontal Diseases -- Tissue Engineering -- Procedure -- Assembly Methods -- Bone Tissue Engineering -- Stem Cell Sources -- Signaling Molecules -- Scaffold/Matrices -- Bioactive Glasses -- Metal-Based materials -- Polymers -- Composites -- Scaffoldfree Techniques -- Biocompatibility -- Drug or Signaling Molecules Delivery -- Future Prospectives -- Further Reading -- Nanobiosensors -- Introduction -- Variations and Types -- Nanoparticle Based Sensors -- Nanotube Based Sensors -- Nanowire Based Sensors -- Components of a typical Biosensors -- Selection and Optimization -- -- Applications -- Cancer -- Detection of diabetes -- Immunoassay (detection of Ab-Ag reaction) -- Detection of pathogenic bacteria -- Future Prospects -- Further Reading -- Health and Medicine -- Introduction -- Keywords -- Nanostructures -- Polymers or Organic NPs -- Nonpoymers or Inorganic Nanoparticles -- Health and Medicine -- Neurodegenerative Disorders -- Tuberculosis -- Ophthalmology -- Respiratory diseases -- Surgery -- Toxicity -- Conclusion -- Further Reading Multiple Choice Questions. .
    Abstract: This book provides that knowledge needed to introduce individuals to the most important research and content on nanotoxicology in nanobiomedicine. Nanotechnology is helping to considerably improve, even revolutionize many technology and industry sectors: information technology, homeland security, medicine, transportation, energy, food safety, and environmental science, among many others. There is an urgent need for a general reference textbook that presents the most recent information on the toxicity and its effects in all these sectors, biomedicine in particular. It includes historical information, nanotoxicology by subject area and or disease, sources of nanomaterials, drug delivery systems and more. Scientists, researchers, and students in all fields that use nanotechnology will find this book essential reading.
    Type of Medium: Online Resource
    Pages: XVII, 179 p. 45 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031242878
    URL: https://doi.org/10.1007/978-3-031-24287-8
    DOI: 10.1007/978-3-031-24287-8
    DDC: 615.90072
    Language: English
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    New Horizons in Meiobenthos Research : Profiles, Patterns and Potentials (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    Description / Table of Contents: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
    Abstract: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 407 p. 49 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031216220
    URL: https://doi.org/10.1007/978-3-031-21622-0
    DOI: 10.1007/978-3-031-21622-0
    DDC: 577.6
    Language: English
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    Visceral Pain (2023)
    Cham :Springer International Publishing :
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    Keywords: Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Description / Table of Contents: Tools for optogenetic probing of nociceptive pathways; Monitoring activity -- An open science model to accelerate the generation, implementation and distribution of optogenetics and viral tools -- Vagal neuroinflammation accompanying respiratory viral infection: An overview of mechanisms and possible clinical significance -- Stress-induced Visceral Analgesia: Concept and Pathways -- Evidence of early life stress exposure and epigenetic modifications in functional chronic pain disorders -- EPIGENETIC REGULATION OF STRESS-INDUCED VISCERAL PAIN -- The biomechanics and mechanotransduction in visceral nociception -- VISCERAL NOCICEPTION IN GASTROINTESTINAL DISEASE -- Epithelial-Neuronal Communication in Visceral Pain -- Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome -- A fentanyl analogue that activates u-opioid receptors in acidified tissues inhibits colitis pain without opioid side effects -- Signalling in the Gut -- Translating colonic sensory afferent peripheral mechanosensitivity into the spinal cord dorsal horn -- Translating colonic afferent peripheral sensitivity into the spinal cord dorsal horn -- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain -- Pre-clinical Models of Endometriosis -- Spinal afferent innervation of the uterus -- Post-infectious bladder hypersensitivity in the development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Abstract: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Type of Medium: Online Resource
    Pages: VIII, 255 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257025
    URL: https://doi.org/10.1007/978-3-031-25702-5
    DOI: 10.1007/978-3-031-25702-5
    DDC: 612.8
    Language: English
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    Sex Differences in Brain Function and Dysfunction (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: Part 1: Considering sex and gender in research studies -- Sex and Gender Science -- Best practices in the study of sex? -- Best practices in the study of Gender Differences -- The special case of a lack of sex differences – the naked mole rat? -- Lateralization and -- Part 2: Sex differences in cognitive and mental health across the lifespan -- Depression -- Schizophrenia -- Immune and neurodevelopmental disorders – autism? -- Social Cognition -- Cognition and cognitive ageing -- Part 3: Diseases of the brain and relevance of sex -- Epilepsy -- Stroke -- AD -- Parkinson’s -- Multiple Sclerosis.
    Abstract: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.
    Type of Medium: Online Resource
    Pages: X, 373 p. 70 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031267239
    Series Statement: Current Topics in Behavioral Neurosciences, 62
    URL: https://doi.org/10.1007/978-3-031-26723-9
    DOI: 10.1007/978-3-031-26723-9
    DDC: 612.8
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    Trials for Cerebellar Ataxias : From Cellular Models to Human Therapies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-24345-5
    DOI: 10.1007/978-3-031-24345-5
    DDC: 612.8
    Language: English
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    Potency Assays for Advanced Stem Cell Therapy Medicinal Products (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Medical microbiology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Medical Microbiology.
    Description / Table of Contents: The Art of Cell Therapy -- Scope and Applicability of Autologous Cell Therapies -- Scale and Accessibility of Allogeneic Cell Therapies -- Acellular Stem Cell Products. Potency Assays: The Buggy Boo of Stem Cell Therapy -- Potency Assay Development: A Keystone for Clinical Use -- Quantifying Critical Quality Attributes -- Advanced Technologies for Potency Assay Measurement -- Potency Quality by Design: Tailoring for Specific Therapy -- Contract Research Organizations Expediting Therapeutic Availability -- Regulatory Authority Perspectives for Potency Release Criteria -- Illustrative Potency Assay Examples from Approved Therapies -- The Integrity of Potency Assays and Safe Intervention -- The Evolving Landscape of Potency Assays.
    Abstract: This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology .
    Type of Medium: Online Resource
    Pages: XIX, 214 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031300400
    Series Statement: Advances in Experimental Medicine and Biology, 1420
    URL: https://doi.org/10.1007/978-3-031-30040-0
    DOI: 10.1007/978-3-031-30040-0
    DDC: 571.6
    Language: English
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    The Nature of Living Being : From Distinguishing Distinctions to Ethics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biology Philosophy. ; Philosophy of nature. ; Ontology. ; Philosophy of Biology. ; Philosophy of Nature. ; Ontology.
    Description / Table of Contents: Chapter 1 Distinction-Distinguishing -- Chapter 2 Distinguishing Distinctions -- Chapter 3 ב and the Emergence of Living Being -- Chapter 4 Empirical Evidence for ב -- Chapter 5 Formal Definition of Distinction -- Chapter 6 The Mathematical Ideal and the Elision of the Subject -- Chapter 7 Four Kinds Of Things -- Chapter 8 [Subjects] -- Chapter 9 Living Being -- Chapter 10 The Paradoxical Nature of Aliveness and [Ethics].
    Abstract: This book proposes a bold idea. Living beings are distinguishing distinctions. Single cells and multicellular organisms maintain themselves distinct by drawing distinctions. This is what organisms are and what they do. From this starting point, key issues examined range across ontology, epistemology, phenomenology, logic, and ethics. Topics discussed include the origin of life, the nature and purpose of biology, the relation between life and logic, the nature and limits of formal logic, the nature of subjects, the subject-object relation, subject-subject relationships and the deep roots of ethics. The book provides a radical new foundation to think about philosophy and biology and appeals to researchers and students in these fields. It powerfully debunks mechanical thinking about living beings and shows the vast reservoir of insights into aliveness available in the arts and humanities. .
    Type of Medium: Online Resource
    Pages: XIX, 320 p. 36 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031247897
    Series Statement: Biosemiotics, 26
    URL: https://doi.org/10.1007/978-3-031-24789-7
    DOI: 10.1007/978-3-031-24789-7
    DDC: 570.1
    Language: English
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    Neurobiological and Psychological Aspects of Brain Recovery (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Abstract: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Type of Medium: Online Resource
    Pages: XXIV, 406 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031249303
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-24930-3
    DOI: 10.1007/978-3-031-24930-3
    DDC: 612.8
    Language: English
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    The Citron Compendium : The Citron (Etrog) Citrus medica L.: Science and Tradition (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Judaism. ; Religion and science. ; Arts. ; Plant Science. ; Judaism. ; Religion and Sciences. ; Arts.
    Description / Table of Contents: The Biology of the Citron -- Citron Genomics -- Citron Phytochemistry -- Selected Aspects of Commercial Production in Etrog Orchards -- Preserving Etrog Quality After Harvest: Doctrine and Practice -- Citron Arthropod Pests in the Mediterranean, Their Origin and Notes On Their Biology and Management -- Diseases of the Etrog Citron and Other Citrus Trees -- The Citron ( Citrus medica L.) in China -- The Citron in Italy and Its cultivation in Calabria -- The Citron in Corsica -- The Citron in the United States -- The Citron in Mediterranean Food and Beverages -- 'Fruit of the Goodly Trees’: The Talmudic Discourse on the Etrog Citron -- From Theophrastus to the Present: The Citron in Medicine -- The Etrog Citron in Art -- The Etrog Citron in Midrashic and Kabbalistic Literature -- From ‘An Etrog’ to ‘One's Etrog’: A Literary Analysis of S.Y. Agnon’s Story -- History of the Citron in Ancient Israel and the Near East -- The Etrog Citron Trail to the North: Genoa and Trieste -- The Corfu Etrog Citron Polemic -- The Grafted Etrog Citron Controversy -- Etrog Citrons of the Land of Israel in Modern Times.
    Abstract: This comprehensive book covers the theoretical and practical aspects of citron trees and fruit. The citron (Citrus medica L.), one of the three primary species ancestral to most citrus types, is used for traditional medicine and is highly revered in the Jewish religion during the Tabernacles feast, referred to by the name 'Etrog'. This book’s three sections address biology (botany, genomics, Chinese and Mediterranean citrons, diseases, pests, and horticulture), tradition (Talmudic discourse, mysticism, medicine, literature, art, food, and beverages) and history (archaeology, trade, grafting controversies); these sections are supplemented by a glossary and pictorial album. The 22 chapters, some new and some translated and considerably expanded from the 2018 Hebrew edition, were written by world-renowned specialists from Israel, Italy, France, the U.S.A., China and Australia. The book is written in an accessible scientific style aimed at a wide range of readers. .
    Type of Medium: Online Resource
    Pages: XVIII, 607 p. 228 illus., 196 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257759
    URL: https://doi.org/10.1007/978-3-031-25775-9
    DOI: 10.1007/978-3-031-25775-9
    DDC: 580
    Language: English
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    Heart Valves : From Design to Clinical Implantation (2023)
    Cham :Springer International Publishing :
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    Keywords: Cardiovascular system. ; Physiology. ; Biomedical engineering. ; Heart Surgery. ; Cardiology. ; Cardiovascular Physiology. ; Biomedical Engineering and Bioengineering. ; Cardiac Surgery. ; Cardiology.
    Description / Table of Contents: ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE. - The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Complex repair of CHD requiring conduits OR valve replacement outside of the ROSS procedure -- VALVE REPAIR AND REPLACEMENT -- Heart valve disease -- History of heart valve repair -- The Ross Procedure -- The Use of Echocardiographic imaging of Valves -- Advanced 3D imaging (CT and MRI) and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Post TAVR PCI -- Complex Procedures in TAV, SAV, HARPOON, BASILICA w/ case studies -- Tissue engineered heart valves -- New trends for valve replacement like the Ozaki procedure -- Post-operative management of valves: On-X valve in post anticoagulation management -- TESTING, REGULATORY and TRAINING ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Virtual Prototyping and 3D Printing For Simulation -- Computational Modeling, Validation, Verification and Uncertainty: Device simulation in Valvular Anatomies -- Procedural Training and Education: Mixed Realities.
    Abstract: This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
    Type of Medium: Online Resource
    Pages: XVII, 615 p. 252 illus., 206 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031255410
    URL: https://doi.org/10.1007/978-3-031-25541-0
    DOI: 10.1007/978-3-031-25541-0
    DDC: 573.1
    Language: English
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    3D Printing of Sustainable Insect Materials (2023)
    Cham :Springer International Publishing :
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    Keywords: Food science. ; Food security. ; Food Analysis. ; Chemistry. ; Food Science. ; Food Security. ; Food Engineering. ; Food Studies. ; Food Chemistry.
    Description / Table of Contents: Entomophagy in 3D Food Printing -- Entomophagy and its Application through 3D Printing for Sustainable Food Development -- Crickets as a promising alternative edible insect: nutritional and technological aspects and 3D printing prospective -- Insects Nutrition And 3D Printing -- Entomophagy: Application of Edible Insects in 3D Printed Foods -- Edible Insects as Materials for Food Printing: Printability and Nutritional value -- Drosophila as a Potential Functional Food: An Edge over other Edible Insects -- 3D printing, insects and food: a bibliometric analysis -- Inkjet-based 3D food printing for sustainable insect materials: A state-of-the-art review and prospective materials -- Extrusion-based 3D printing concept in customized nutritional products -- A Review on Binder jetting and Selective Laser Sintering: a novel assessment of the processes for 3D Insect food printing materials -- Social, Economic, Scientific and Environment Aspects of Entomophagy in 3D Food Printing.
    Abstract: This book compiles a diverse and interdisciplinary range of scientific literature, laboratory developments, industrial implications and future prospects covering Entomophagy in 3D food printing to fight against hunger and nutritional deficiencies. Recent developments in Entomphagy in 3D printing of Drosophila based materials, and their nutritional, social, economic, scientific and environmental aspects. are comprehensively covered. Readers will also find shortcomings, guidelines, and industrial prospects for these materials, with emphasis on processing methods for the extraction of sustainable materials through 3D food printing. 3D Printing of Sustainable Insect Materials focuses on the methodology, technology and processing used for utilizing insects in 3D food printing applications, establishing technology-driven knowledge to fight against hunger. Chapters cover the principles for Entomophagy, insect processing methods, modern 3D food printing technologies, and the theoretical and practical aspects of Emtomophagy in 3D printing, with a special focus on future prospects and technologies. This ground-breaking book will serve knowledge to researchers and industry professionals across the food industry with broad coverage of emerging technologies, materials developed through Entomophagy, functional characterization and the technical details required to produce sustainable insect-based materials through 3D food printing. .
    Type of Medium: Online Resource
    Pages: VIII, 206 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259944
    URL: https://doi.org/10.1007/978-3-031-25994-4
    DOI: 10.1007/978-3-031-25994-4
    DDC: 641.3
    Language: English
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    Data Monitoring Committees (DMCs) : Past, Present, and Future (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    URL: https://doi.org/10.1007/978-3-031-28760-2
    DOI: 10.1007/978-3-031-28760-2
    DDC: 615
    Language: English
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    Handbook of Bioethical Decisions. Volume I : Decisions at the Bench (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Medical sciences. ; Drug development. ; Clinical medicine Research. ; Environment. ; Bioethics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Preclinical Research. ; Clinical Research. ; Environmental Sciences.
    Description / Table of Contents: Foreword - Peter Singer -- Introduction: Biomedical Research in One World: Current and Future Challenges -- Part I - Biomedical Research -- Section One - Genetic and Cell Research -- Chap 1: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Chap 2: Bioethical Decision Making and Genome Editing -- Chap 3: Therapeutic Genome Editing -- Chap 4: Bioethical Decision-Making about Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Chap 5: Gene Therapy and Germline Cells Research -- Chap 6: Bioethical Quandaries in Preimplantation Genetic Diagnosis -- Chap 7: Rare Disease Research -- Chap 8: Limits of Debate: Governance of Human Embryo Research and the Making of the Fourteen-Day Rule -- Chap 9 Human/Non-Human Chimeras -- Chap 10: Human Cloning: Recent Advances and Bioethical Issues -- Section Two - Enhancement Research -- Chap 11: The Evolutionary Optimality Challenge -- Chap 12: Mood Enhancement -- Chap 13: Superior Sport Performance: Ethical and Legal Issues -- Chap 14: Arguments over Life Extension in Contemporary Bioethics -- Section Three - Research with Human Biological Samples and Health Data -- Chap 15: Research with Human Biological Samples. Systematization of the Phases and Affected Rights -- Chap 16: Biobanks for Biomedical Research: Evolution and Future -- Chap 17: Biobanking in Global Health & Research -- Chap 18: Ethical and Legal Considerations in Genomic Data Sharing: Evolution of the Discourse and the Road Ahead -- Section Four - Biomedical Challenges in Research -- Chap 19: Human Challenge Trials in Pandemics: Risks and Benefits -- Chap 20: Ethical Considerations for Vaccine Research -- Chap 21: Global Health Partnerships and Emerging Infectious Disease -- Chap 22: Precision Medicine -- Chap 23: The Development, Implementation, and Oversight of Artificial -- Intelligence in Health Care: Legal and Ethical Issues -- Part II - Animals, Food and Environment -- Section One - Using Animals in Scientific Research -- Chap 24: The Use of Animals in Basic Biological Research -- Chap 25: The Use of Animals in the Study of Human Disease: Key Roles of General Ethical Principles -- Chap 26: Ethical Issues Concerning Genetically Modified Animals for the Study of Human Diseases -- Chap 27: Of Mice-Rats and Pig-Men: Ethical Issues in the Development of Human/Nonhuman Chimeras -- Chap 28: Animals in Research in Pharmaceutical Industry -- Chap 29: Animal Use in Toxicity Studies -- Chap 30: Ethical Issues from the Use of Animals in the Cosmetics and Fashion Industries -- Chap 31: Is it Time to Phase Out the Use of all Nonhuman Primates in Invasive Research? -- Chap 32: Growing Human Organs Inside Animals -- Chap 33: Animal Cloning -- Section Two - Decision Making and Alternatives to Animal Use in Research -- Chap 34: Replacement, Reduction and Refinement -- Chap 35: Integrating Human and Nonhuman Research Ethics -- Chap 36: Regulation of Animal Research -- Section Three - GMOs for Global Challenges -- Chap 37: Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology -- Chap 38: GMOs and Human and Environmental Safety -- Chap 39: GMOs and Sustainable Agriculture.
    Abstract: The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for “at the bench” bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general. .
    Type of Medium: Online Resource
    Pages: XX, 778 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294518
    Series Statement: Collaborative Bioethics, 2
    URL: https://doi.org/10.1007/978-3-031-29451-8
    DOI: 10.1007/978-3-031-29451-8
    DDC: 174.2
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    Senescence Back and Forth (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Medicine Research. ; Biology Research. ; Public health. ; Biotechnology. ; Psychiatry. ; Ageing. ; Biomedical Research. ; Public Health. ; Chemical Bioengineering. ; Psychiatry.
    Description / Table of Contents: Senescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.
    Abstract: This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
    Type of Medium: Online Resource
    Pages: XXIII, 132 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031322761
    URL: https://doi.org/10.1007/978-3-031-32276-1
    DOI: 10.1007/978-3-031-32276-1
    DDC: 571.878
    Language: English
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    Plant-Based Therapeutics, Volume 1 : Cannabis sativa (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Alternative medicine. ; Pharmacology. ; Medicinal chemistry. ; Physiology. ; Agriculture. ; Plant Science. ; Complementary and Alternative Medicine. ; Pharmacology. ; Medicinal Chemistry. ; Physiology. ; Agriculture.
    Description / Table of Contents: Chapter 1 The History of Cannabis -- Chapter 2 The Bioactive Components of Plants -- Chapter 3 Chemical Constituents of Cannabis -- Chapter 4 The Bioactive Components of Cannabis -- Chapter 5 Neurological Effects of Cannabis -- Chapter 6 Psychotropic Effects of Cannabis -- Chapter 7 The Analgesic effects of Cannabis -- Chapter 8 Cannabis and Perinatal Development -- Chapter 9 Cannabis and Multiple Sclerosis -- Chapter 10 Cannabis and Cancer -- Chapter 11 Cannabis and Parkinson’s disease -- Chapter 12 Cannabis and the Skin -- Chapter 13 Antiviral Activities of Cannabis -- Chapter 14 Alkaline Phosphatase Stimulation.
    Abstract: By examining historical applications of the compounds found in plants, this five-volume series serves as a reference for quality assurance, research, product development, and regulatory guidance of the compounds found in plant-based medicines. This work supports the growing consumers' interest in herbal medicine for wellness and health. Plant-Based Therapeutics, Volume 1: Cannabis sativa, the first in the series, covers a unique plant species and provides the framework to integrate its evidence-based scientific discoveries with healthcare therapies. Cannabis has been used in religious ceremonies and medical purposes for thousands of years. Cannabidiol (CBD), the main non-psychoactive component of Cannabis, was isolated in the 1940s, and its structure was established in the 1960s. In 1964 tetrahydrocannabinol (THC), the psychoactive component, was isolated. Cannabis has more than 500 components, of which 104 cannabinoids have been identified. Two of them, THC and CBD, have been the primary components of scientific investigations. They were approved by the FDA for chemotherapy-induced nausea and vomiting in 1985; for appetite stimulation in wasting conditions, such as AIDS, in 1992, and in 2018 for treating two forms of pediatric epilepsy, Dravet syndrome and Lennox-Gastaut syndrome. Beyond the indications for which cannabinoids are FDA-approved, the evidence reveals that cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Thus, other constituents of Cannabis are extremely promising either as individual compounds or their potential synergistic or entourage effects in the treatment of numerous medical conditions. .
    Type of Medium: Online Resource
    Pages: XXI, 657 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031351556
    URL: https://doi.org/10.1007/978-3-031-35155-6
    DOI: 10.1007/978-3-031-35155-6
    DDC: 580
    Language: English
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    Statistical Methods at the Forefront of Biomedical Advances (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biometry. ; Biomedical engineering. ; Bioinformatics. ; Biological models. ; Biostatistics. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Biological Models.
    Description / Table of Contents: Forecasting of SARS-COV-2 dynamic: beyond the classical SIR model -- Derivation of OED methods for applications in cytogenetic biodosimetry -- Minimum Phi-divergence tests for ophthalmological data grouped in clusters -- Multimodality test for determining which genes distinguish oncological patients -- Exploring the relationship between different cancer sites using disease mapping models -- Advances in flow cytometry gating based on distances and divergences in probability spaces -- Application of quantile regression models for biomedical data -- Hippocampus shape analysis via skeletal models and kernel smoothing -- Methods for analysis of microbiome count data with applications -- The FMM model as a classifier of cardiovascular pathologies -- A novel statistical insight of the circadian markers that govern cardiac rhythms -- Sleep and circadian synchronization assessment from multivariate recordings. .
    Abstract: This book presents novel statistics methods and reproducible software that helps to solve challenging problems in biomedicine. Specifically, it consists of a collection of 11 chapters contributed by some of the leading experts in the mathematical and statistical field which address new challenges in very disparate biomedical areas, such as genomics, cancer, circadian biology, microbiome, mental disorders, and more. The mathematical rigor is written in a user-friendly way to serve a general biomedical audience ranging from trainees or students to doctors, as well as scientific researchers, university departments, and PhD students.
    Type of Medium: Online Resource
    Pages: XI, 276 p. 71 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031327292
    URL: https://doi.org/10.1007/978-3-031-32729-2
    DOI: 10.1007/978-3-031-32729-2
    DDC: 570.15195
    Language: English
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    Psammic Peinobiomes : Nutrient-Limited Ecosystems of the Upper Orinoco and Rio Negro Basins (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotic communities. ; Soil science. ; Plant ecology. ; Geomorphology. ; Ecophysiology. ; Conservation biology. ; Ecology . ; Ecosystems. ; Soil Science. ; Plant Ecology. ; Geomorphology. ; Ecophysiology. ; Conservation Biology.
    Description / Table of Contents: 1 Introduction -- Part I: Forest and woodland biomes -- 2 White sand ecosystems in the Amazon basin: geographic distribution, distinctive features, and ecology. An overview -- 3 The forests of the Rio Negro basin in the north-western Amazon: a phytosociological classification -- 4 Amazon caatinga complex: sclerophyllous vegetation on nutrient-poor white sand soils -- Part II: Meadow biomes -- 5 Mapping white-sand ecosystems by integrating Global PALSAR-2 and SENTINEL-1 with NDVI (LANDSAT data) -- 6 The study areas: landscapes and soils -- 7 Soil properties, formation, distribution, and classification -- 8 Origin and sources of sand: from highlands to lowlands -- 9 Sand dynamics and distribution: a geo-sedimentological approach -- 10 Features and trends of meadow landscape evolution -- 11 Meadow phytodiversity: flora, endemism, vegetation types, and geographic distribution patterns -- 12 Synthesis: white-sand and meadow-vegetation relationships.
    Abstract: The book represents a multidisciplinary approach to understanding soil–landscape–vegetation relationships and, specifically, the ecophysiology of plant communities developing on sandy soils of very low fertility that are subject to seasonal flooding. It provides an overview of the white sand ecosystems within the Amazon basin, and focuses on the forest and herbaceous (meadows) vegetation growing on the dystrophic sandy soils of the upper Negro and Orinoco river basins. Several chapters describe physiographic aspects of the study area using integrated remote sensing and in situ sampling. By doing so they attain a comprehensive description of the origin and evolution of soils and landscapes, an advanced classification of soils, and a mapping of the geographic distribution of psammophilous vegetation. This volume also provides a phytosociological classification of extensive forested areas, and a detailed description of the structure and diversity of little-known herbaceous formations. It targets professionals in the fields of ecology, ecophysiology, geomorphology, soils, vegetation, and the environmental sciences. The information it offers may be of significant use to researchers, protected area planners, and environmental policy makers.
    Type of Medium: Online Resource
    Pages: XIV, 541 p. 136 illus., 122 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031207990
    Series Statement: Ecological Studies, Analysis and Synthesis, 247
    URL: https://doi.org/10.1007/978-3-031-20799-0
    DOI: 10.1007/978-3-031-20799-0
    DDC: 577
    Language: English
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    The Almond Tree Genome (2023)
    Cham :Springer International Publishing :
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    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Almond genome analysis and breeding -- Labelling Almond Genome: SAM, QTLs and Association mapping -- Identification of natural variation in almond target genes -- Recent advances on almond bitterness expression at genomic and trascriptomic level -- Recent advances on flower self-incompatibility expression at genomic and transcriptomic level -- Molecular basis of abiotic and biotic stresses in almond -- Genomics for fruit quality traits in almond: QTLs vs Association mapping -- Transcriptional changes associated with flower bud dormancy in almond and other Prunus species: DNA sequence motifs, mRNA and miRNA expression, transcription factors, chromatin modifications and phytohormone signaling -- Almond transcriptome analysis using high-throughput sequencing technologies -- Almond miRNA expression and horticultural implications.
    Abstract: This book brings together the latest information on almond genomics and transcriptomics, with a particular focus on cutting-edge findings, tools, and strategies employed in genome sequencing and analysis with regard to the most important agronomic traits. Cultivated almond [(Prunus dulcis (Miller) D. A. Webb, syn. Prunus amygdalus Batsch., Amygdalus communis L., Amygdalus dulcis Mill.)] is a tree crop producing seeds of great economic interest, and adapted to hot and dry climates. Domesticated in Southeast Asia, its small diploid genome and phenotypic diversity make it an ideal model to complement genomics studies on peach, generally considered to be the reference Prunus species. Both represent consanguineous species that evolved in two distinct environments: warmer and more humid in the case of peach, and colder and xerophytic for almond. The advent of affordable whole-genome sequencing, in combination with existing Prunus functional genomics data, has now made it possible to leverage the novel diversity found in almond, providing an unmatched resource for the genetic improvement of this species.
    Type of Medium: Online Resource
    Pages: XVIII, 171 p. 33 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030303020
    Series Statement: Compendium of Plant Genomes,
    URL: https://doi.org/10.1007/978-3-030-30302-0
    DOI: 10.1007/978-3-030-30302-0
    DDC: 581.35
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    Computerized Systems for Diagnosis and Treatment of COVID-19 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biomedical engineering. ; Therapeutics. ; Diagnosis. ; Diseases. ; Biophysics. ; Biomedical Engineering and Bioengineering. ; Therapeutics. ; Diagnosis. ; Diseases. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Clinical impact of automatic diagnostic systems -- Lung segmentation from XRay -- Lung segmentation from CT Scan -- Covid Automatic Diagnostic based on XRay -- Covid Automatic Diagnostic based on CTScan -- Cardiovascular analysis of covid patients based on ECG -- Cognitive analysis of covid patients based on EEG -- AI Controlled Mechanical Ventilator for COVID-19 patients.
    Abstract: This book describes the application of signal and image processing technologies, artificial intelligence, and machine learning techniques to support Covid-19 diagnosis and treatment. The book focuses on two main applications: critical diagnosis requiring high precision and speed, and treatment of symptoms, including those affecting the cardiovascular and neurological systems. The areas discussed in this book range from signal processing, time series analysis, and image segmentation to detection and classification. Technical approaches include deep learning, transfer learning, transformers, AutoML, and other machine learning techniques that can be considered not only for Covid-19 issues but also for different medical applications, with slight adjustments to the problem under study. The Covid-19 pandemic has impacted the entire world and changed how societies and individuals interact. Due to the high infection and mortality rates, and the multiple consequences of the virus infection in the human body, the challenges were vast and enormous. These necessitated the integration of different disciplines to address the problems. As a global response, researchers across academia and industry made several developments to provide computational solutions to support epidemiologic, managerial, and health/medical decisions. To that end, this book provides state-of-the-art information on the most advanced solutions.
    Type of Medium: Online Resource
    Pages: VI, 209 p. 91 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031307881
    URL: https://doi.org/10.1007/978-3-031-30788-1
    DOI: 10.1007/978-3-031-30788-1
    DDC: 610.28
    Language: English
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    Baobab : The Hadza of Tanzania and the Baobab as Humanity's Tree of Life (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant anatomy. ; Plant ecology. ; Plants Development. ; Plant physiology. ; Evolution (Biology). ; Anthropology. ; Plant Anatomy and Morphology. ; Plant Ecology. ; Plant Development. ; Plant Physiology. ; Evolutionary Biology. ; Anthropology.
    Description / Table of Contents: Part I: THE BAOBAB -- Chapter 1. The distinguishing features of the tree of life and the baobab -- Chapter. 2. The Hadza and studies that document their use of the baobab -- Part II: THEORETICAL FRAMEWORK -- Chapter. 3. Hominin adaptation as the development of a gendered forager division of labor -- Chapter. 4. Correlated handiness and bipedality as the outcome of the multidimensional selective pressures of the forager way of life -- Part III: MATERIAL CULTURE AND TECHNOLOGY -- Chapter. 5. Africa’s premier fiber tree -- Chapter. 6. The baobab and container -- Chapter. 7. The baobab and fire in hominin evolution -- Part IV: ENVIRONMENTAL CONSIDERATIONS -- Chapter. 8. The baobab and Hadza acquisition, management and use of water -- Chapter. 9. Baobab seasonality -- PART V: BAOBAB RESOURCES: FOOD, HEALTH, AND EXCHANGE BENEFITS -- Chapter. 10. The Hadza preeminent fruit tree -- Chapter. 11. Baobab beverages -- Chapter. 12. Africa’s honey tree -- Chapter. 13. The baobab and birds -- Chapter. 14. The Hadza diet and the baobab as a source of other animal foods -- Chapter. 15. The baobab as a hunger-time tree of life -- Chapter. 16. The baobab and health -- Chapter. 17. The baobab and exchange -- Part VI: THE INSPIRATIONAL VALUE OF THE BAOBAB -- Chapter. 18. The baobab in Hadza inspirational life -- Chapter. 19. The baobab as a fertility tree -- Chapter. 20. Other inspirational uses of the baobab -- Chapter. 21. The baobab and danger -- Chapter. 22. The baobab and death -- Part VII. THE HADZA AND BAOBAB REGENERATION -- Chapter. 23. The baobab and Hadza central-place residential camps -- Chapter. 24. Hadza influence on baobab regeneration -- Chapter. 25. The Hadza baobab retreat -- Literature cited -- Index. .
    Abstract: Modern humans, descendants of a founding population that separated from chimpanzees some five to eight million years ago, are today the only living representative of a branching group of African apes called hominins. Because of its extraordinary size and shape, the baobab (Adansonia digitata L.) has long been identified as the most striking tree of Africa’s mosaic savanna, the landscape generally regarded as the environment of hominin evolution. This book makes the case for identifying the baobab as the tree of life in the hunter-gatherer adaptation that was the economic foundation of hominin evolution. The argument is based on the significance of the baobab as a resource-rich environment for the Hadza of northeastern Tanzania, who continue to be successful hunter-gatherers of the African savanna.
    Type of Medium: Online Resource
    Pages: XXIX, 382 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031264702
    URL: https://doi.org/10.1007/978-3-031-26470-2
    DOI: 10.1007/978-3-031-26470-2
    DDC: 571.32
    Language: English
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    Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biochemical markers. ; Proteins. ; Metabolism. ; Genomics. ; Biomarkers. ; Proteins. ; Metabolism. ; Genomics.
    Description / Table of Contents: Chapter 1. The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology and Variants of Concern -- Chapter 2. Long-term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics -- Chapter 3. Consequences of the Lockdown - Domestic Violence during the COVID-19 Pandemic -- Chapter 4. Psychological distress impact of Coronavirus disease (COVID-19) outbreak on three continents: A systematic review and meta-analysis -- Chapter 5. A Molecular Biomarker-based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms -- Chapter 6. Genetic Associations with Coronavirus Susceptibility and Disease Severity -- Chapter 7. COVID Diagnostics: from Molecules to Omics -- Chapter 8. Assessing Biomarkers in Viral Infection -- Chapter 9. Proteomic Investigation of COVID-19 Severity During the Tsunamis Second Wave in Mumbai -- Chapter 10. NMR-Metabolomics in COVID-19 Research -- Chapter 11. Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection -- Chapter 12. Red Cell Distribution Width as a Prognostic Indicator for Mortality and ICU Admission in Patients with COVID-19 -- Chapter 13. Predicting the COVID-19 Patients Status using Chest CT Scan Findings: A Risk Assessment Model Based on Decision Tree Analysis -- Chapter 14. Inferring Recombination Events in SARS-CoV-2 Variants In Silico -- Chapter 15. Amplicon-based Nanopore Sequencing of Patients Infected by the SARS-CoV-2 Omicron (B.1.1.529) Variant in India -- Chapter 16. Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics -- Chapter 17. Machine Learning and COVID-19: Lessons from SARS-CoV-2 -- Chapter 18. The Relationship between Psoriasis, COVID-19 Infection and Vaccination during Treatment of Patients -- Chapter 19. Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study -- Chapter 20. Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective -- Chapter 21. Antiviral Mechanisms of Curcumin and its Derivatives in Prevention and Treatment of COVID-19: A review -- Chapter 22. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial -- Chapter 23. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach -- Chapter 24. The Potential Effect of Royal Jelly on Biomarkers Related to COVID-19 Infection and Severe Progression -- Chapter 25. Statins: Beneficial Effects in Treatment of COVID-19 -- Chapter 26. Multiplex Immunoassay Approaches Using Luminex® xMAP® Technology for the Study of COVID-19 Disease -- Chapter 27. Rapid Detection of SARS-CoV-2 Variants of Concern by Genomic Surveillance Techniques.
    Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.
    Type of Medium: Online Resource
    Pages: XI, 513 p. 87 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031280122
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1412
    URL: https://doi.org/10.1007/978-3-031-28012-2
    DOI: 10.1007/978-3-031-28012-2
    DDC: 610.72
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    Handbook of Bioethical Decisions. Volume II : Scientific Integrity and Institutional Ethics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Science Moral and ethical aspects. ; Normativity (Ethics). ; Bioethics. ; Biomedical Research. ; Science Ethics. ; Normative Ethics.
    Description / Table of Contents: Foreword: On Handbooks -- Introduction -- Scientific Integrity and Institutional Ethics: Challenges and Perspectives -- Part I - Research Ethics -- Section One - Scientific Integrity and Research Misconduct -- Chap 1: Data Alteration -- Chap 2: Research Misconduct and Questionable Research Practices -- Chap 3: Ethics of Authorship -- Chap 4: Dissemination of Research Results -- Chap 5: Conflicts of Interest in Research -- Chap 6: A Priori Publication Agreements to Improve Adherence to Ethics in Research Publications -- Section Two - Conducting Ethical Research -- Chap 7: Freedom of Scientific Research and Primacy of Human Being: Practical and Epistemological Tensions -- Chap 8: Exploitation in Biomedical Research -- Chap 9: Selection of Research Subjects: Methodological and Ethical Issues -- Chap 10: Confidentiality and Privacy in Digital Clinical Trials -- Chap 11: Dematerialization and Intellectual Property in the Biosciences -- Part II - Institutional Ethics and Bioethics Committees -- Section One - Institutional Ethics -- Chap 12: Historical Development of Institutional Ethics and Bioethics -- Chap 13: Principles of Institutional Ethics -- Chap 14: Institutional Review Boards (IRB): US Perspectives -- Chap 15: Decision Making within Institutions -- Chap 16: Scientific Advances, Ethical Oversight and Legal Institutionality -- Section Two - Ethics and Bioethics Committees -- Chap 17: Members and Structure of Institutional Bioethics Committees -- Chap 18: Foundations of Bioethical Decision-Making in Bioethics and Biolaw -- Chap 19: Just Doing Bioethics': Policy, Principle, and Process -- Chap 20: Ethics Education and Institutional Ethics Committees -- Chap 21: Role of Ethics Committees in Emergency Use of Unproven Interventions Outside Research -- Chap 22: The Ethics of Resource Allocation in Pandemics: A Bayesian Model -- Section Three - Bioethical Issues in Institutional Ethics -- Chap 23: Scientific Knowledge and Social Responsibility -- Chap 24: Conscientious Objection -- Chap 25: Institutional Liability in Research -- Chap 26: Research Assessments Should Recognize Responsible Research Practices. Narrative Review of a Lively Debate and Promising Developments -- Chap 27: Coercion in Mental Health Treatment.
    Abstract: The Handbook of Bioethical Decisions Volume II addresses and analyzes the most important ethical concerns and moral quandaries related to scientific integrity and institutional ethics. It counts on two parts, Part One: Research Ethics, which addresses issues related to Scientific Integrity, Research Misconduct and Conducting Ethical Research, and Part Two: Institutional Ethics and Bioethics Committees, which explores Institutional Ethics issues, Ethics and Bioethics Committees’ roles and scopes, and Bioethical Issues in Institutional Ethics. Consequently, the Handbook, Vol. II, offers a remarkable collection of works by outstanding international experts on institutional and research ethics, in order for bioethics practitioners to obtain better elements to address key issues related to integrity in research as well as to decision-making processes. In this fashion, this volume is a valuable resource for professionals working on different bioethical and biomedical fields, such as, ethics and bioethics committees, health care institutions, biomedical and pharmacological companies, and academic settings, among others. Chapter 26 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 487 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294556
    Series Statement: Collaborative Bioethics, 3
    URL: https://doi.org/10.1007/978-3-031-29455-6
    DOI: 10.1007/978-3-031-29455-6
    DDC: 174.2
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    Trending Topics in Escherichia coli Research : The Latin American Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bacteria. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Immunology. ; Food Safety measures. ; Therapeutics. ; Bacteria. ; Medical Microbiology. ; Biomedical Research. ; Immunology. ; Food Safety. ; Therapeutics.
    Description / Table of Contents: Chapter 1. WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a PostPandemic World -- Chapter 2. Recent progress on enterotoxigenic E. coli (ETEC) and antibiotic resistance in pathogenic E. coli -- Chapter 3. New concepts on domestic and wild reservoirs, and transmission of E. coli and its environment -- Chapter 4. New molecular mechanisms of virulence and pathogenesis in E. coli.-Chapter 5. Bovine reservoir of STEC and EPEC: advances and new contributions -- Chapter 6. Phages and Escherichia coli -- Chapter 7. Insights into animal carriage and pathogen surveillance in Latin America: the case of STEC and APEC -- Chapter 8. Shiga Toxin and its effect on the Central Nervous System -- Chapter 9. Relevance of Escherichia coli in fresh produce safety -- Chapter 10. Quantitative Microbial Risk Assessment of Hemolytic Uremic Syndrome due to Beef Consumption: Impact of Interventions to Reduce the Presence of Shiga Toxin-Producing Escherichia coli -- Chapter 11. An Updated Overview on the Resistance and Virulence of UPEC -- Chapter 12. Interactions of pathogenic Escherichia coli with gut microbiota -- Chapter 13. Emergence of Hybrid Escherichia coli Strains -- Chapter 14. Genomic analysis of pathogenic E. coli strains in Latin America -- Chapter 15. Therapeutic options for diarrheagenic Escherichia coli.
    Abstract: Latin America has been at the forefront in combating infections caused by Escherichia coli strains in humans, animals, and the environment. The continuous emergence and evolution of pathogenic E. coli strains associated with human and animal infections have demonstrated that (i) groups of related pathogenic E. coli are responsible for most infections caused by this bacterial species; (ii) diverse virulence phenotypes expressed during infection defined each one of these pathogroups; (iii) the geographical distribution of pathogroups in Latin America and the evolution of new isolates was defined by the dominant pathogroup and presence of distinct virulence strains; (iv) acquisition of mobile elements or accumulation of point mutations accelerate the development of antibiotic resistance in some of these strains. The Latin American Coalition for Escherichia coli Research (LACER), a multidisciplinary network of over seventy research groups in eleven Latin American countries and the USA, was established in 2009 to apply One Health principles in defining and combating this pathogen. The previous edition of this text, Escherichia coli in the Americas was the culmination of the investigators' wisdom about E. coli, from its role as a commensal bacterium to its characteristics as a pathogen. This new edition introduces recent advances and contextualizes all aspects of E. coli in a One Health perspective, from the environment, to animals, to humans. It addresses E. coli interactions with host microbiota, CNS, and phages, and includes cutting edge insights on hybrid strains, molecular mechanisms of virulence and pathogenesis, domestic and wild reservoirs, disease surveillance in Latin America, food safety, and new therapies. Crucially, it also presents translations and analysis of key reports on Escherichia coli published in Spanish and Portuguese. This book serves as a critical resource for scientists in industry and academia, clinicians managing associated infections, and trainees and students studying basic and clinical aspects of E. coli pathogenesis. .
    Type of Medium: Online Resource
    Pages: XX, 363 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031298820
    URL: https://doi.org/10.1007/978-3-031-29882-0
    DOI: 10.1007/978-3-031-29882-0
    DDC: 579.3
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    Exogenous Enzymes as Feed Additives in Ruminants (2023)
    Cham :Springer International Publishing :
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    Keywords: Animal culture. ; Physiology. ; Veterinary medicine. ; Animal Science. ; Animal Physiology. ; Veterinary Science.
    Description / Table of Contents: Chapter. 1. Yeast as a source of exogenous enzymes in feeding ruminants -- Chapter. 2. Yeast culture and direct-fed microbes: Modes of action and beneficial applications in ruminants -- Chapter. 3. Effects of Exogenous Enzymes on the Nutritive value of some Fibrous Forage in Ruminants -- Chapter. 4. Exogenous fibrolytic enzymes: for the better utilization of Guinea grass and rice straw as ruminant feeds -- Chapter. 5. Role of Exogenous Enzymes in Feed Digestibility and Reducing the Emission Intensity of Enteric Methane Production in Ruminants -- Chapter. 6. Inclusion of exogenous fibrolytic enzymes in the diets of dairy cows and ewes: Effect on milk yield and milk composition -- Chapter. 7. Determining the Effect Enzyme Addition to Locally Available Forages in Mongolia Using In Vitro and In Vivo Techniques -- Chapter. 8. Fungi as a source of exogenous enzymes to feed ruminants -- Chapter. 9. Dietary inclusion of exogenous fibrolytic enzyme in southern China to enhance fibrous feed utilization by goats and cattle.
    Abstract: This book addresses a global issue of increasing high quality food from ruminant animals while reducing their impacts on the environment. However, one of the main constraints to livestock development and the underlying cause of the low productivity in many developing countries is inadequate nutrition associated with inefficient utilization of forages and fibrous feed resources. In many countries, fibrous feed makes up the bulk of available feed resource base, which is characterized by scarcity and fluctuating supply in the quantity and quality of feed resources, nutrient imbalance as seen in many native pastures, grasslands and crop residues-based feeding systems with limited use of commercial concentrate feeds such as soybean, cottonseed and groundnut meals, etc. Furthermore, the production of methane, an important greenhouse gas (GHG), from ruminants fed highly fibrous diets such as straws and stover is higher than those animals fed better quality forages or concentrate diets. Recent research shows that supplementing livestock diets with exogenous fibre degrading enzymes can improve feed utilization by enhancing intake, fibre degradation in the rumen and overall digestibility of fibrous feeds which in turn leads to improved animal performance, farmers’ income, and a reduction in GHG emissions. The book editors would like to acknowledge the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture for funding part of the studies that make up some of these chapters and were part of the final reports of a coordinated research project financed by IAEA.
    Type of Medium: Online Resource
    Pages: VIII, 195 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031279935
    URL: https://doi.org/10.1007/978-3-031-27993-5
    DOI: 10.1007/978-3-031-27993-5
    DDC: 636
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    Transforming Biocities : Designing Urban Spaces Inspired by Nature (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Urban ecology (Biology). ; Sustainable architecture. ; Biodiversity. ; Forestry. ; Urban Ecology. ; Sustainable Architecture/Green Buildings. ; Biodiversity. ; Forestry.
    Description / Table of Contents: Towards the Development of a Conceptual Framework of BioCities -- Urban sustainable futures: concepts and policies leading to BioCities -- Biodiversity and Ecosystem Functions as Pillars of BioCities -- Green Infrastructure and Urban Forests for BioCities: Strategic and Adaptive Management -- Mitigation and Adaptation for Climate Change: The Role of BioCities and Nature Based Solutions -- BioCities as Promotors of Health and Wellbeing -- Forests, Forest Products and Services to Activate a Circular Bioeconomy for City Transformation -- Innovative Design, Materials, and Construction Models for BioCities -- The Social Environment of BioCities -- From BioCities to BioRegions and Back: Transforming Urban-Rural Relationships -- The Enabling Environment for BioCities -- Towards BioCities – The Pathway to Transition.
    Abstract: This edited volume centers around the concept of BioCities, which aim to unify nature and urban spaces in order to reverse the effects of global climate change and inequity. Following this principle, the authors propose multiple approaches for sustainable city growth. The discussed concepts are not only relevant for newly constructed cities, but offer transformative perspectives for existing settlements as well. Placing nature at the forefront of city planning is not an entirely new concept, so the authors build on established ideas like the garden city, green city, eco-city, or smart city. All chapters aim to highlight aspects to develop a city that is a resilient nature-based socio-ecological system. Many of these concepts were formed in an effort to copy the best traits of a forest ecosystem: a home for many different species that build complex communities. Much like many of our forests, urban areas are managed by humans for multifunctional purposes, using living and abiotic components. This viewpoint helps to understand the potential and limitations of sustainable growth. With these chapters, the authors want to inspire planners, ecologists, urban foresters and decision makers of the future.
    Type of Medium: Online Resource
    Pages: X, 304 p. 59 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294662
    Series Statement: Future City, 20
    URL: https://doi.org/10.1007/978-3-031-29466-2
    DOI: 10.1007/978-3-031-29466-2
    DDC: 577.56
    Language: English
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