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  • Organic Chemistry  (1.885)
  • Computational Chemistry and Molecular Modeling  (1.060)
  • Animals  (922)
  • 1990-1994  (3.867)
  • 1980-1984
  • 1955-1959
  • 1993  (1.913)
  • 1992  (1.954)
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  • 1990-1994  (3.867)
  • 1980-1984
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  • 1
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    Crystal structure of the repetitive segments of spectrin (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and spectrin) contain tandemly repeated segments and form resilient cellular meshworks by cross-linking actin filaments. The structure of one of the repetitive segments of alpha-spectrin was determined at a 1.8 angstrom resolution. A segment consists of a three-helix bundle. A model of the interface between two tandem segments suggests that hydrophobic interactions between segments may constrain intersegment flexibility. The helix side chain interactions explain how mutations that are known to produce hemolytic anemias disrupt spectrin associations that sustain the integrity of the erythrocyte membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, Y -- Winograd, E -- Viel, A -- Cronin, T -- Harrison, S C -- Branton, D -- CA 13202/CA/NCI NIH HHS/ -- HL 17411/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2027-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266097" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Crystallization ; Drosophila ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Spectrin/*chemistry
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Army targets a potential vaccine against cholesterol (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, J -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):1974-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266090" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibody Formation ; Cholesterol/administration & dosage/*immunology ; Humans ; Hypercholesterolemia/*prevention & control ; Liposomes ; *Vaccines
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: A human Wilms tumor cell line (RM1) was developed to test the tumor suppressor activity of WT1, a zinc finger transcription factor that is expressed in the developing human kidney and is mutationally inactivated in a subset of Wilms tumors. Transfection of each of four wild-type WT1 isoforms suppressed the growth of RM1 cells. The endogenous WT1 transcript in these cells was devoid of exon 2 sequences, a splicing alteration that was also detected in varying amounts in all Wilms tumors tested but not in normal kidney. Production of this abnormal transcript, which encodes a functionally altered protein, may represent a distinct mechanism for inactivating WT1 in Wilms tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haber, D A -- Park, S -- Maheswaran, S -- Englert, C -- Re, G G -- Hazen-Martin, D J -- Sens, D A -- Garvin, A J -- CA37887/CA/NCI NIH HHS/ -- CA58596/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2057-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Genetics, Massachusetts General Hospital Cancer Center, Boston 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266105" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alternative Splicing ; Amino Acid Sequence ; Animals ; Base Sequence ; Cell Division/genetics ; DNA-Binding Proteins/biosynthesis/*genetics/physiology ; Genes, Wilms Tumor/genetics/*physiology ; Humans ; Mice ; Mice, Nude ; Molecular Sequence Data ; Neoplasm Transplantation ; RNA, Messenger/genetics ; Tumor Cells, Cultured ; WT1 Proteins ; Wilms Tumor/*genetics/*pathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Ice man's fungi: discussion rekindled (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poder, R -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):1956.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8086009" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Freezing ; History, Ancient ; Hominidae/*microbiology ; Humans ; Male ; *Mummies ; Polyporaceae/*isolation & purification
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: The CD4 molecule is essential for binding HIV particles, but is not sufficient for efficient viral entry and infection. The cofactor was shown to be dipeptidyl peptidase IV (DPP IV), also known as CD26. This serine protease cleaves its substrates at specific motifs; such motifs area also highly conserved in the V3 loops of HIV-1, HIV-2, and related simian isolates. Entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines was inhibited by a specific monoclonal antibody against DPP IV or specific peptide inhibitors of this protease. Coexpression of human CD4 and CD26 in murine NIH 3T3 cells rendered them permissive to infection by HIV-1 and HIV-2. These observations could provide the basis for developing simple and specific inhibitors of HIV and open a possibility for vaccine development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Callebaut, C -- Krust, B -- Jacotot, E -- Hovanessian, A G -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2045-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite de Virologie et Immunologie Cellulaire, UA CNRS, Institut Pasteur, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7903479" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3T3 Cells ; Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Antigens, Differentiation, T-Lymphocyte/*physiology ; CD4-Positive T-Lymphocytes/*microbiology ; Cell Line ; Dipeptidyl Peptidase 4 ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & ; inhibitors/*physiology ; HIV Envelope Protein gp120/physiology ; HIV-1/*pathogenicity ; HIV-2/*pathogenicity ; HeLa Cells ; Humans ; L Cells (Cell Line) ; Leukocytes, Mononuclear/microbiology ; Mice ; Molecular Sequence Data ; Peptide Fragments/physiology ; Trypsin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Connexin mutations in X-linked Charcot-Marie-Tooth disease (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: X-linked Charcot-Marie-Tooth disease (CMTX) is a form of hereditary neuropathy with demyelination. Recently, this disorder was mapped to chromosome Xq13.1. The gene for the gap junction protein connexin32 is located in the same chromosomal segment, which led to its consideration as a candidate gene for CMTX. With the use of Northern (RNA) blot and immunohistochemistry technique, it was found that connexin32 is normally expressed in myelinated peripheral nerve. Direct sequencing of the connexin32 gene showed seven different mutations in affected persons from eight CMTX families. These findings, a demonstration of inherited defects in a gap junction protein, suggest that connexin32 plays an important role in peripheral nerve.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergoffen, J -- Scherer, S S -- Wang, S -- Scott, M O -- Bone, L J -- Paul, D L -- Chen, K -- Lensch, M W -- Chance, P F -- Fischbeck, K H -- GM37751/GM/NIGMS NIH HHS/ -- NS01565/NS/NINDS NIH HHS/ -- NS08075/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2039-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Pennsylvania Medical School, Children's Hospital of Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266101" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Charcot-Marie-Tooth Disease/*genetics ; Chromosome Mapping ; Connexins/analysis/*genetics ; Female ; Genetic Linkage ; Humans ; Male ; Molecular Sequence Data ; *Mutation ; Nerve Fibers, Myelinated/chemistry ; Nerve Tissue Proteins/analysis ; Peripheral Nerves/chemistry ; Rats ; X Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Receptive field reorganization in dorsal column nuclei during temporary denervation (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: Altered sensory input can result in the reorganization of somatosensory maps in the cerebral cortex and thalamus, but the extent to which reorganization occurs at lower levels of the somatosensory system is unknown. In cat dorsal column nuclei (DCN), the injection of local anesthetic into the receptive fields of DCN neurons resulted in the emergence of a new receptive field in all 13 neurons studied. New receptive fields emerged rapidly (within minutes), sometimes accompanied by changes in adaptation rates and stimulus selectivity, suggesting that the new fields arose from the unmasking of previously ineffective inputs. Receptive field reorganization was not imposed by descending cortical inputs to the DCN, because comparable results were obtained in 10 additional cells when the somatosensory and motor cortex were removed before recording. These results suggest that mechanisms underlying somatotopic reorganization exist at the earliest stages of somatosensory processing. Such mechanisms may participate in adaptive responses of the nervous system to injury or continuously changing sensory stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pettit, M J -- Schwark, H D -- NS 25729/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2054-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of North Texas, Denton 76203.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266104" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain Mapping ; Cats ; Cerebral Cortex/physiology ; Efferent Pathways/physiology ; Hair/innervation ; Lidocaine/pharmacology ; Neuronal Plasticity/*physiology ; Sensation/*physiology ; Skin/innervation ; Spinal Cord/drug effects/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    p53: at the crossroads of molecular carcinogenesis and risk assessment (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, C C -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):1980-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Human Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266092" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Codon/genetics ; *Genes, p53 ; Humans ; *Mutation ; Neoplasms/etiology/*genetics ; Risk
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Peptide translocation by variants of the transporter associated with antigen processing (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: Major histocompatibility complex (MHC) class I molecules associate with peptides that are delivered from the cytosol to the lumen of the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Liver microsomes of SHR and Lewis rats, which express different alleles of TAP (cim(b) and cim(a), respectively), accumulate different sets of peptides. Use of MHC congenic rats assigned this difference to the MHC, independent of the class I products expressed. Both the cim(a) and cim(b) TAP complexes translocate peptides with a hydrophobic carboxyl terminus, but translocation of peptides with a carboxyl-terminal His, Lys, or Arg residue is unique to cim(a). Thus, the specificity of the TAP peptide translocator restricts the peptides available for antigen presentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heemels, M T -- Schumacher, T N -- Wonigeit, K -- Ploegh, H L -- R01 AI3 3456-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2059-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266106" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *ATP-Binding Cassette Transporters ; Alleles ; Amino Acid Sequence ; Animals ; Antigen Presentation/*physiology ; Biological Transport/physiology ; Carrier Proteins/genetics/*physiology ; Histocompatibility Antigens Class I/physiology ; Histocompatibility Antigens Class II/genetics/*physiology ; In Vitro Techniques ; Microsomes, Liver/metabolism ; Molecular Sequence Data ; Oligopeptides/*metabolism ; Rats ; Rats, Inbred BN ; Rats, Inbred Lew ; Rats, Inbred SHR ; Substrate Specificity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Chromosome condensation in Xenopus mitotic extracts without histone H1 (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-24
    Beschreibung: The contribution of histone H1 to mitotic chromosome condensation was examined with the use of a cell-free extract from Xenopus eggs, which transforms condensed sperm nuclei into metaphase chromosomes. When H1 was removed from the extract, the resultant metaphase chromosomes were indistinguishable from those formed in complete extract. Nucleosomal spacing was the same for both. Thus, H1 is not required for the structural reorganization that leads to condensed metaphase chromosomes in this egg extract.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohsumi, K -- Katagiri, C -- Kishimoto, T -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2033-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cell and Developmental Biology, Faculty of Biosciences, Tokyo Institute of Technology, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266099" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell-Free System ; Chromosomes/*physiology ; Histones/*physiology ; Mitosis/*genetics ; Xenopus laevis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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