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  • Articles  (49)
  • Articles: DFG German National Licenses  (49)
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  • Calcium  (31)
  • Cartilage  (19)
  • Springer  (49)
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  • Articles  (49)
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  • Articles: DFG German National Licenses  (49)
  • Latest Papers from Table of Contents or Articles in Press
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  • Springer  (49)
  • American Association for the Advancement of Science
  • American Chemical Society (ACS)
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  • 1
    Electronic Resource
    Electronic Resource
    Additional evidence for the binding of calcium ions to elastin at neutral sites (1974)
    Springer
    Calcified tissue international 14 (1974), S. 317-325 
    Details
    ISSN: 1432-0827
    Keywords: Calcification ; Neutral sites ; Elastin ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Des études précédentes suggèrent la présence de groupements carboxyles, sulfhydriles et aminés dans les sites de liaison en calcium de l'élastine. La possibilité de l'existence de sites neutres de liaison en calcium au niveau de l'élastine a été étudiée dans ce travail. Une augmentation de la fixation du calcium au niveau de l'élastine est observée après des modifications de dissolution qui ont aussi provoqué des modifications de structure de la protéine. Dans des mélanges méthanol-H2O, les liaisons du calcium semblent indépendantes du pH et de la force ionique. Sur dix ions testés (Ca2+, CO2+, Na2+, Cu2+, Zn2+, Cr3+, Pb+2, K+, Rb+ et Mg2+) seule la liaison du calcium est nettement augmentée, lorsque le méthanol est ajouté. Il semble que les sites neutres sont importants pour les divers rapports entre calcium et élastine et servent, peut-être, comme centres de nucléation au cours de la calcification de la protéine.
    Abstract: Zusammenfassung Vorgängige Studien haben die Bedeutung der Carboxyl-, Sulfhydryl- und Aminogruppen als Stellen der Calciumbindung im Elastin gezeigt. Die vorliegende Arbeit hatte zum Ziel, die Rolle der neutralen Koordinationsstellen im Elastin als mögliche Calcium-Bindungsseite abzuklären. Die Calciumbindindung an das Elastin wurde durch solche Lösungsmittelveränderungen erhöht, die auch gleichartige Verschiebungen im Proteinmolekül bewirkten. In Methanol-Wasser-Mischungen schien die Calciumbindung nicht von Veränderungen des pH oder der Ionenstärke abhängig zu sein. Von 10 Ionen, bei welchen die Bindung überprüft wurde, war einzig diejenige des Calciums signifikant erhöht, wenn Methanol zugesetzt wurde. Es wird vorgeschlagen, daß die neutralen Stellen für die verschiedenen Vorgänge, bei welchen Calcium und Elastin beteiligt sind, eine wichtige Rolle spielen und vielleicht für die Verkalkung der Proteine als Nukleationszentren in Frage kommen.
    Notes: Abstract Previous studies have implicated carboxyl groups, sulphhydryl groups and amino groups as the sites for calcium binding in elastin. In this study, the concept was investigated that neutral co-ordinating sites in elastin may also provide calcium binding sites. Calcium binding to elastin was increased upon solvent changes which also effected conformational changes in the protein. In methanol-H2O mixtures calcium binding appeared to be independent of changes in pH and ionic strength. Of ten ions tested (Ca2+, Co2+, Na+, Cu2+, Zn2+, Cr3+, Pb+2, K+, Rb+, and Mg2+), only calcium binding was significantly increased when methanol was added. It is proposed that neutral sites are important to the various relationships involving calcium and elastin and perhaps serve as nucleation centers in the calcification of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060306
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of vitamin D analogues on bone resorption (1974)
    Springer
    Calcified tissue international 15 (1974), S. 333-339 
    Details
    ISSN: 1432-0827
    Keywords: Vitamin D ; Bone ; Resorption ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract A series of analogues of vitamin D have been tested for their ability to stimulate bone resorption in two test systems used previously to investigate the metabolites of vitamine D. These analogues were tested (a) by directly comparing their action on bone explants of mouse half-calvariain vitro, and (b) by injecting them into young mice and measuring the degree of resorptionin vitro when explants were prepared 18 hours after the injection. It is concluded that the key functional groups concerned with enhancing the activity of vitamin D3 are the 1α- and the 25-hydroxyl,both together; the cis ring structure for ring A appears necessary. 1α-Hydroxycholecalciferol (1α-OHD3) is about as active as 25-OHD3 in the direct test, but its potency is much nearer to that of 1,25-(OH)2D3 when tested by the second (indirect) method; it seems likely that 1α-OHD3 is converted into 1,25-(OH)2D3 in vivo. The results are discussed in relation to the designing of analogues for clinical and experimental use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02059069
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of age on bone calcium and phosphate metabolism in organ culture (1974)
    Springer
    Calcified tissue international 16 (1974), S. 89-92 
    Details
    ISSN: 1432-0827
    Keywords: Age ; Bone culture ; Calcium ; Phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Calvaria taken from mice aged 0, 1, 3 and 5 days were cultured for 48 h, in control medium (no added hormone), or in the presence of PTH (0.5 U/ml) or CT (50 mCl/ml). In the control group, there was a shift from net uptake of Ca and P (0- and 1-day bones) to net release (5-day bones). CT-treated bones of all ages took up Ca from the culture medium, but the percentage uptake declined with increasing age. Bones exposed to PTH released Ca and P to the culture medium, regardless of age. The changes with increasing age may be related to an increase in mineralization and other aspects of maturation in these bones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008215
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  • 4
    Electronic Resource
    Electronic Resource
    Serum calcium, phosphate and alkaline phosphatase and morphometric bone examinations in 30 patients with renal insufficiency (1974)
    Springer
    Calcified tissue international 16 (1974), S. 129-138 
    Details
    ISSN: 1432-0827
    Keywords: Serum ; Calcium ; Phosphate ; Alkaline phosphatase ; Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract In 30 patients with chronic renal insufficiency (16 non-dialysed and 14 on dialysis) serum calcium, phosphate and alkaline phosphatase were determined and, in a crest biopsy specimen, morphometric determinations of bone qualities were calculated. A positive correlation was established between serum alkaline phosphatase, the osteoblast surface and the active resorption surface in both dialysed and non-dialysed patients. A positive correlation was also established between the osteoblast surface and the active resorption. In the non-dialysed patients a negative correlation was established between serum calcium and the osteoid surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008218
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  • 5
    Electronic Resource
    Electronic Resource
    Glycosaminoglycans of iliac crest cartilage in spondyloepiphyseal dysplasia congenita (1974)
    Springer
    Calcified tissue international 16 (1974), S. 183-192 
    Details
    ISSN: 1432-0827
    Keywords: Mucopolysaccharides ; Spondyloepiphyseal dysplasia ; Cartilage ; Growth defects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Iliac crest cartilage biopsies from five children with spondyloepiphyseal dysplasia congenita contained increased amounts of chondroitin-6-sulfate and keratan sulfate. The increase was similar to that observed in the cartilage of patients with Morquio's disease. However, unlike patients with Morquio's disease, those with spondyloepiphyseal dysplasia congenita did not excrete an abnormal amount of keratan sulfate in urine. Spondyloepiphyseal dysplasia congenita can be considered a mucopolysaccharidosis without mucopolysacchariduria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008225
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  • 6
    Electronic Resource
    Electronic Resource
    Effects ofSolanum malacoxylon on embryonic bonein vitro and on isolated mitochondria (1974)
    Springer
    Calcified tissue international 16 (1974), S. 219-226 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Phosphate ; ATP ; Calcium ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract An active constituent of the leaves ofSolanum malacoxylon (SM) is shown to promote calcium resorption and citrate production in embryonic chick frontal bone culturedin vitro. When injected into rats, SM reduces the ATP content of liver and kidneys. This phenomenon may be related to the ability of SM to stimulate mitochondrial ATPase activity at pH 9.4. SM significantly reduces the concentration of phosphate necessary to alter the uptake of calcium and respiration of siolated mitochondria. The data suggest that SM influences calcium and phosphate metabolism by affecting ion movements into and out of mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008229
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  • 7
    Electronic Resource
    Electronic Resource
    Cytochrome oxidase activities of various cartilage tissues during growth and development (1970)
    Springer
    Calcified tissue international 5 (1970), S. 85-90 
    Details
    ISSN: 1432-0827
    Keywords: Cartilage ; Electron transport ; Cytochrome oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Lorsque des lapins augmentent pondéralement de 165 à 2,205 grammes, l'activité en cytochrome oxydase de cartilage épiphysaire homogénéisé n'est pas modifiée, en utilisant des tests enzymatiques manométriques et spectrophotométriques; alors que l'activité en oxydase du cartilage xyphoide du sternum et de l'oreille homogénéisé décroit. Des spectres d'absorption optique des tissus cartilagineux, réalisés pour la première fois à l'aide de fragments d'oreilles de lapin et de cartilage embryonnaire de poulets, montrent un maximum d'absorption caractéristique pour le système respiratoire final des mitochondries, y compris les composés b, c et oxydasiques ainsi que les flavoprotéines.
    Abstract: Zusammenfassung Während Kaninchen ihr Körpergewicht von 165 auf 2205 g erhöhen, erfolgt keine Veränderung in der Cytochrom-Oxydase-Aktivität der epiphysären Knorpel-Homogenate in manometrischen und spectrophotometrischen Enzymversuchen, jedoch vermindern sich die Oxydase-Aktivitäten von xiphisternalen und von Ohrknorpel-Homogenaten. Lichtabsorptionsspektren von Knorpelgewebe wurden zum ersten Mal gemacht, indem Streifen von Kaninchenohrstücken und Stücke von Kükenembryoknorpel verwendet wurden. Solche Spektren zeigen charakteristische Absorptionsmaxima für den terminalen Atmungskomplex der Mitochondrien, einschließlich b, c und Oxydasekomponenten sowie Flavoprotein.
    Notes: Abstract As rabbits increase in size from 165 grams to 2,205 grams body weight, cytochrome oxidase activity of epiphyseal cartilage homogenates does not change in manometric and spectrophotometric enzyme assays, whereas the oxidase activities of xiphisternal and ear cartilage homogenates decline. Light absorption spectra of cartilage tissues were made for the first time, using strips of rabbit ear and pieces of chick embryo cartilage. Such spectra reveal characteristic absorption maxima for the terminal respiratory complex of mitochondria, including b, c and oxidase components and flavoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02017538
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  • 8
    Electronic Resource
    Electronic Resource
    Vitamin A deficiency stimulated phosphatase activity in epiphyseal chick cartilage (1974)
    Springer
    Calcified tissue international 14 (1974), S. 251-255 
    Details
    ISSN: 1432-0827
    Keywords: Cartilage ; Bone ; Vitamin A ; Phosphatases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Au cours d'une étude du cartilage épiphysaire de poulets normaux et déficients en vitamine A, la composition organique et l'activité phosphatasique du cartilage au repos, du cartilage en voie d'ossification et de l'os nouvellement formé ont été mesurées. Le cartilage en voie d'ossification et l'os nouvellement formé ont un contenu plus élevé en matériel inorganique, phosphate et collagène que le cartilage au repos. Une déficience en vitamine A provoque une augmentation du contenu en phospholipide de tous les trois tissus. Le cartilage au repos, en cas de déficience en vitamine A, présente, après homogénéisation et centrifugation, un surnageant dont l'activité en phosphatase alcaline et en glycérophosphatase est plus élevée que celle des témoins. Il semble que les effets enzymatiques de l'avitaminose A soient liés à des altérations de la membrane lysosomiale avec décharge de phosphatases. La minéralisation normale semble aussi faire intervenir une activité phosphatasique.
    Abstract: Zusammenfassung Diese Arbeit beschreibt Untersuchungen des Epiphysenknorpels bei normalen Küken und solchen mit Vitamin-A-Mangel. Die organische Zusammensetzung und die Phosphatase-Aktivität in ruhendem Knorpel, ossifizierendem Knorpel und neugebildetem Knochen wurden gemessen. Der ossifizierende Knorpel und der neugebildete Knochen hatten einen höheren Gehalt an anorganischem Material, an Phosphat und Kollagen als der ruhende Knorpel. Vitamin-A-Mangel führte zu einem erhöhten Phospholipidgehalt in allen drei Geweben. Nach Homogenisierung und Zentrifugierung fand sich im Überstand des ruhenden Knorpels von Vitamin-A-Mangelgewebe eine höhere alkalische Phosphatase- und Glycero-phosphatase-Aktivität als bei den Kontrollen. Es wird angenommen, daß die Wirkung des Vitamin A-Mangels auf die Enzyme im Zusammenhang steht mit der Schädigung der lysosomalen Membran, wobei Phosphatasen freigesetzt werden, und daß die normale Mineralisierung die Phosphatasen-Aktivität ebenfalls anregt.
    Notes: Abstract This paper reports studies of the epiphyseal cartilage in normal and vitamin A deficient chicks. The organic composition and the phosphatase activity in the resting cartilage, ossifying cartilage and new bone were measured. The ossifying cartilage and new bone had a higher content of inorganic material, phosphate and collagen than the resting cartilage. Vitamin A deficiency caused increase in the phospholipid content of all three tissues. The resting cartilage from vitamin A deficient tissue had, after homogenisation and centrifugation, a supernatant with an activity of alkaline phosphatase and glycerophosphatase higher than that in control samples. It is considered that effects of vitamin A deficiency on enzymes are related to defects of the lysosomal membrane with release of phosphatases, and that normal mineralisation also involves phosphatases activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060299
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  • 9
    Electronic Resource
    Electronic Resource
    The lipids of matrix vesicles from bovine fetal epiphyseal cartilage (1974)
    Springer
    Calcified tissue international 14 (1974), S. 275-281 
    Details
    ISSN: 1432-0827
    Keywords: Calcification ; Cartilage ; Lipids ; Membranes ; Vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les vésicules matricielles sont des particules extracellulaires, entourées par une membrane, qui sont nombreuses dans la matrice du cartilage en voie de calcification et qui sont en rapport morphologique avec le dépôt minéral. Les vésicules matricielles et les cellules de l'épiphyse d'os longs d'embryons de veaux sont libérées par digestion grâce à la collagénase et séparées par centrifugation différentielle. Les vésicules ainsi obtenues sont riches en lipides et contiennent significativement plus de sphingomyéline et phosphatidyl sérine que les fractions cellulaires. Le rapport moles de cholestérol sur moles de phospholipides totaux est plus élevé dans les vésicules que dans les cellules; ce résultat est en accord avec l'origine des vésicules au niveau des membranes cellulaires des chondrocytes.
    Abstract: Zusammenfassung Matrixvesikel sind extrazelluläre, membrangebundene Teilchen, welche in der Matrix von verkalkendem Knorpel gehäuft vorkommen und welche in morphologischem Zusammenhang mit der Mineralablagerung in diesem Gewebe stehen. Matrixvesikel und Epiphysenzellen aus Röhrenknochen von Kalbsembryonen wurden mittels Collagenaseverdauung freigesetzt und durch Differential-Zentrifugierung getrennt. Die Vesikelpräparate waren reich an Lipidien und enthielten bedeutend mehr Sphingomyelin und Phosphatidylserin als die Zellfraktionen. Das molare Verhältnis Cholesterol/Gesamtlipide war in den Vesikeln höher als in den Zellen; dieser Befund stimmt mit der Tatsache überein, daß die Vesikel ihren Ursprung in den Plasmamembranen der Chondrozyten haben.
    Notes: Abstract Matrix vesicles are extracellular, membrane-bounded particles which are abundant in the matrix of calcifying cartilage and which are morphologically related to the deposition of mineral in this tissue. The matrix vesicles and cells of the epiphyses of the long bones of fetal calves were liberated by digestion with collagenase and separated by differential centrifugation. Vesicle preparations were found to be lipid-rich and to contain significantly more sphingomyelin and phosphatidyl serine than cellular fractions. The ratio, moles cholesterol to moles total phospholipid, was higher in vesicles than in cells, a finding which is consistent with vesicles having their origins in the plasma membranes of the chondrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060301
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of ethylenediaminetetraacetate (EDTA) on urinary excretion of hydroxyproline, calcium and phosphorus in the rat (1974)
    Springer
    Calcified tissue international 16 (1974), S. 1-12 
    Details
    ISSN: 1432-0827
    Keywords: EDTA ; Bone resorption ; Parathyroid hormone ; Calcium ; Hydroxyproline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The effects of ethylenediaminetetraacetate (EDTA) were studied in rats. Intravenous infusion of 4.84 mM Na2EDTA increased the urinary excretion of calcium six-fold, phosphorus three-fold and hydroxyproline 55% in 158 g thyroparathyroidectomized (TPTXed) rats. Calcitonin (25 MRC mU/rat/h) abolished the sodium EDTA-induced increase in hydroxyproline excretion, presumptive evidence that sodium EDTA was acting on bone. To determine whether the changes induced by sodium EDTA are due to lowering of plasma calcium, rats were infused with 4.84 mM ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA), a more specific calcium chelator. EGTA increased the urinary excretion of calcium and phosphorus (P〈0.001) but not hydroxyproline in thyroparathyroidectomized rats. Furthermore, when TPTXed rats were infused with calcium EDTA (4.84 mM Ca2EDTA) in order that ionic calcium concentration would not be altered, hydroxyproline excretion was again markedly increased but phosphorus excretion was decreased by 26%. Since the displacement of the sodium ions in Na2EDTA by calciumin vivo is instantaneous, and since calcium EDTA itself induces collagenolysis, the increase in urinary hydroxyproline excretion due to sodium EDTA cannot be attributed solely to lowering of plasma calcium. From these data two conclusions are drawn. First, sodium EDTA enhances bone breakdown independently of its effect on parathyroid hormone secretion. Second, since bone plays a major role in the maintenance of plasma calcium, interpretation of results should be made with caution in those investigations in which EDTA is used to study calcium homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008209
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