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  • 1
    Online Resource
    Online Resource
    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cancer Neuroscience (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    URL: https://doi.org/10.1007/978-3-031-32429-1
    DOI: 10.1007/978-3-031-32429-1
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Hepatobiliary Cancers: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    URL: https://doi.org/10.1007/978-3-031-44528-6
    DOI: 10.1007/978-3-031-44528-6
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Gastrointestinal Cancers: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    URL: https://doi.org/10.1007/978-3-031-48371-4
    DOI: 10.1007/978-3-031-48371-4
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Artificial Intelligence and Precision Oncology : Bridging Cancer Research and Clinical Decision Support (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.
    Abstract: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIV, 315 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031215063
    URL: https://doi.org/10.1007/978-3-031-21506-3
    DOI: 10.1007/978-3-031-21506-3
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Molecular Biology of Human Cancers (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    URL: https://doi.org/10.1007/978-3-031-16286-2
    DOI: 10.1007/978-3-031-16286-2
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    URL: https://doi.org/10.1007/978-981-19-8911-7
    DOI: 10.1007/978-981-19-8911-7
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Oncology: Genomics, Precision Medicine and Therapeutic Targets (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    URL: https://doi.org/10.1007/978-981-99-1529-3
    DOI: 10.1007/978-981-99-1529-3
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cancer Research: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.
    Abstract: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).
    Type of Medium: Online Resource
    Pages: XI, 611 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324581
    Series Statement: Interdisciplinary Cancer Research, 1
    URL: https://doi.org/10.1007/978-3-031-32458-1
    DOI: 10.1007/978-3-031-32458-1
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    The African Marine Litter Outlook (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Water. ; Hydrology. ; Africa Economic conditions. ; Oceanography. ; Sustainability. ; Pollution. ; Waste Management/Waste Technology. ; Water. ; African Economics. ; Ocean Sciences. ; Sustainability.
    Description / Table of Contents: Chapter 1. Introduction to Marine Litter in Africa -- Chapter 2. Marine litter sources and distribution pathways -- Chapter 3. Impacts and Threats of Marine Litter to Africa Chapter -- Chapter 4. Legal and Policy Frameworks to address marine litter through improved livelihoods -- Chapter 5. The way forward, building upon-the-ground innovation.
    Abstract: This open access book provides a cross-sectoral, multi-scale assessment of marine litter in Africa with a focus on plastics. From distribution, to impacts on environmental and human health, this book looks at what is known scientifically. It includes a policy analysis of the instruments that currently exist, and what is needed to help Africa tackle marine litter—including local and transboundary sources. Across 5 chapters, experts from Africa and beyond have put together a summary of the scientific knowledge currently known about marine litter in Africa. The context of the African continent and future projections form a backdrop on which the scientific knowledge is built. This scientific knowledge incorporates quantities, distributions, and pathways of litter into the marine environment, highlighting where the impacts of marine litter are most felt in Africa. These impacts have widespread effects, with ecological, social, economic, and human health repercussions. While containing detailed scientific information, this book provides a sound knowledge base for policymakers, NGOs and the broader public.
    Type of Medium: Online Resource
    Pages: XXII, 224 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086267
    URL: https://doi.org/10.1007/978-3-031-08626-7
    DOI: 10.1007/978-3-031-08626-7
    DDC: 363.73
    Language: English
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  • 11
    Online Resource
    Online Resource
    Agricultural Implications of Fukushima Nuclear Accident (IV) : After 10 Years (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Agriculture. ; Radiation dosimetry. ; Forestry. ; Physiology. ; Environmental monitoring. ; Pollution. ; Agriculture. ; Radiation Dosimetry and Protection . ; Forestry. ; Animal Physiology. ; Environmental Monitoring.
    Description / Table of Contents: 1. An Overview of our research -- 2. Recovery of Food Production from Radioactive Contamination Caused by the Fukushima Nuclear Accident -- 3. Annual Reduction of Transfer Factors of Radiocesium from Soil to Rice Cultivated in a KCl Fertilized and Straw Plowed-in Paddy Field from 2015 to 2021 -- 4. Effects of radiocesium from suspended matter and fallout on agricultural products -- 5. Verification of Uptake and Transport Properties of Cesium in Hydroponically Cultivated Quercus Serrata -- 6. Candidates for breeding target genes related to cesium transport in plants after the Fukushima Daiichi Nuclear Power Plant accident -- 7. Evaluation of the Absorption of Different Forms of Cesium from Soil -- 8. Structure, Composition, and Physicochemical Properties of Radiocesium-Bearing Microparticles Emitted by the Fukushima Daiichi Nuclear Power Plant Accident -- 9. Verification of Effects on Crops and Surrounding Environment in Agriculture Using Radioactively Contaminated Grass Silage Compost Made by Aerobic Ultra-High Temperature Fermentation -- 10. Transport of 137Cs into Fruits after External Deposition onto Japanese Persimmon Trees -- 11. Progress Towards Managing Radiocesium Contamination in Orchards -- 12. Overview of Radiocesium Dynamics in Forests: First Decade and Future Perspectives -- 13. Toward the Estimation of Radiocesium Activity Concentration in Trunks of Coppiced Quercus Serrata: Leaf Availability Instead of Felling -- 14. Decomposition of Organic Matters in a Forest Floor Enhanced Downward Migration of Radioactive Cs after the Accident of the FDNPP -- 15. Effect of exchangeable and non-exchangeable potassium in soil on cesium uptake by Quercus serrata seedlings -- 16. Ten-year Transition of Radiocesium Contamination in Wild Mushrooms in the University of Tokyo Forests after the Fukushima Accident -- 17. Challenge to resume production of mushroom bed logs by potassium fertilizer application -- 18. Studies on the revitalization of radioactive-contaminated mushroom log forests: focus on shoots -- 19. Contribution of cesium-bearing microparticles to cesium in soil and river water of the Takase River watershed and their effect on the distribution coefficient -- 20. Global Fallout: Radioactive Materials from Atmospheric Nuclear Tests That Fell Half a Century Ago and Where to Find Them -- 21. Resilience Education Program in Iitate Village for the Young Generation.
    Abstract: This open access book presents the findings from on-site research into radioactive cesium contamination in various agricultural systems affected by the Fukushima Daiichi Nuclear Power Plant accident in March 2011. This fourth volume in the series reports on studies undertaken at contaminated sites such as farmland and forests, focusing on soil, water, mountain, agricultural products, and animals. It also provides additional data collected in the subsequent years to show how the radioactivity levels in agricultural products and their growing environments have changed with time and the route by which radioactive materials entered agricultural products as well as their movement between different components (e.g., soil, water, and trees) within an environmental system (e.g., forests). The book covers various topics, including radioactivity testing of food products; decontamination trials for rice and livestock production; the state of contamination in, trees, mushrooms, and timber; the dynamics of radioactivity distribution in paddy fields and upland forests; damage incurred by the forestry and fishery industries; and the change in consumers’ attitudes. In the series of this book, a real-time radioisotope imaging system has been introduced, a pioneering technique to visualize the movement of cesium in soil and in plants. This is the only book to provide systematic data on the actual change of radioactivity, which is of great value to all researchers who wish to understand the effect of radioactive fallout on agriculture. In addition, it helps the general public better understand radio-contamination issues in the environment. The project is ongoing; the research groups from the Graduate School of Agricultural and Life Sciences of The University of Tokyo continue their work in the field further to evaluate the long-term effects of the Fukushima accident.
    Type of Medium: Online Resource
    Pages: XIII, 276 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811993619
    URL: https://doi.org/10.1007/978-981-19-9361-9
    DOI: 10.1007/978-981-19-9361-9
    DDC: 363.73
    Language: English
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  • 12
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    Online Resource
    Human Health Risk Assessment of Toxic Chemical Pollutants in Stormwater : Implications for Urban Stormwater Reuse (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environmental protection. ; Civil engineering. ; Pollution. ; Water. ; Soil and Water Protection.
    Description / Table of Contents: Background -- Research design -- Linking traffic and land use to stormwater quality -- Human health risk assessment from toxic chemical pollutants in stormwater -- Implications for stormwater management and recommendations for future research.
    Abstract: This book presents a detailed analysis in relation to human health risk assessment of the main toxic chemical pollutants in urban stormwater generated from urban traffic and land use activities. The knowledge presented in this book was derived based on comprehensive experimental investigations including field sampling, laboratory testing, mathematical modelling, spatial analysis and multivariate and univariate statistical data analyses. The key highlights of the book include the quantitative assessment of the human health risk posed by key toxic chemical pollutants in urban stormwater and the development of linkages between risk and traffic and land use. Additionally, a suite of mathematical equations are presented to predict human health risk based on traffic and land use characteristics through mathematical modelling. These outcomes can significantly assist in effective stormwater risk management under changing traffic and land use in the urban environment. The knowledge presented is of particular interest to readers such as stormwater treatment design specialists, decision-makers and urban planners since these outcomes provide practical suggestions and recommendations for effective urban stormwater treatment design.
    Type of Medium: Online Resource
    Pages: VIII, 86 p. 58 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811996160
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-981-19-9616-0
    DOI: 10.1007/978-981-19-9616-0
    DDC: 363.73
    Language: English
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  • 13
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    Online Resource
    Persistent Pollutants in Water and Advanced Treatment Technology (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Environmental protection. ; Civil engineering. ; Environmental engineering. ; Pollution. ; Soil and Water Protection. ; Environmental Civil Engineering.
    Description / Table of Contents: Impact of Persistent Pollutants on Water Quality -- Marine microplastics: abundance, ecotoxic consequences of associated anthropogenic contaminants and interactions with microorganisms -- World profile of foreseeable strategies for the removal of per- and polyfluoroalkyl substances (PFASs) from water -- Plasticizers, plastic monomers, and their transformation products in environmental waters and wastewater -- Occurrence and Removal of phthalates from aqueous medium using bismuth tungstate-based photocatalysts -- Application of electrochemical technologies for the efficacious removal of persistent organic pollutants from wastewater -- Recent progress in Electrochemical/Electro-oxidation technology: its applicability in highly efficient treatment of persistent organic pollutants specially from coal processed wastewater.
    Abstract: This contributed volume discusses the current status of the occurrences, fate and transport of persistent pollutants in water and wastewater. This contents compile the state-of-the-art of emerging technologies such as nanotechnology, advanced oxidation process, membrane processes, sorption, etc. for the clean-up of persistent pollutants in water including heavy metals, pharmaceuticals, phenolic compounds as well as microplastics and their by-products. This volume will be useful as a guide for the researchers to build strategies to deal with persistent pollutant. It also discusses the principal aspects of degradation mechanism of the pollutants, toxic by-products and effectiveness of the emerging technologies. This volume will be a useful guide for those working in soil and water protection, and environmental civil engineering. .
    Type of Medium: Online Resource
    Pages: XVII, 477 p. 136 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819920624
    Series Statement: Energy, Environment, and Sustainability,
    URL: https://doi.org/10.1007/978-981-99-2062-4
    DOI: 10.1007/978-981-99-2062-4
    DDC: 363.73
    Language: English
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  • 14
    Online Resource
    Online Resource
    Remediation of Chromium-Contaminated Soil: ​Theory and Practice​ (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Environmental chemistry. ; Environmental monitoring. ; Pollution. ; Environmental Chemistry. ; Environmental Monitoring.
    Description / Table of Contents: Contamination characteristics of soils and biological and chemical behavior of chromium in soil.-Mechanisms of Cr(VI) reduction by microorganisms -- Microbial remediation of chromium-contaminated soil -- Mechanism of chemical reduction of Cr(VI) -- Chemical remediation of chromium-contaminated soil -- Case of chrome-contaminated site remediation project.
    Abstract: In accordance with the global needs of heavy metal-contaminated site remediation, this book systematically introduces the latest theories and technical achievements of microbial and chemical treatment for the chromium pollution in the chromium slag and chromium-contaminated soil, combined with the author's research achievements over the decades. The book focuses on the biological and chemical behavior of chromium in soil, microbial, and chemical remediation for the chromium-contaminated soil and the cases of chromium-contaminated site remediation project. This book is used by the scientific researchers and engineering technicians engaged in chromium chemical industry and environmental protection. It is also used as a textbook and reference book for graduate students in environmental science and engineering, soil science, chemistry and chemical engineering, and other related fields.
    Type of Medium: Online Resource
    Pages: XI, 303 p. 190 illus., 142 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819954636
    Series Statement: Environmental Science and Engineering,
    URL: https://doi.org/10.1007/978-981-99-5463-6
    DOI: 10.1007/978-981-99-5463-6
    DDC: 363.73
    Language: English
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  • 15
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    Online Resource
    Green Nanoremediation : Sustainable Management of Environmental Pollution (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Green chemistry. ; Environmental chemistry. ; Pollution. ; Green Chemistry. ; Environmental Chemistry.
    Description / Table of Contents: Chapter. 1. Important Features of Nanomaterials for Environmental Remediation -- Part. I: Green nanoremediation: generating eco-friendly nanoremediators -- Chapter. 2. Green-synthesis of nanomaterials for environmental remediation -- Chapter. 3. Nanoremediation: main strategies, advantages and disadvantages - Strategic methods of nanoremediation through nanomaterials synthesized from microbes -- Chapter. 4. Fungi-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 5. Algae-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 6. Plant-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 7. Innovations on the synthesis of metal nanoparticles to nanoremediation -- Part II: Important green nanomaterials in the management of environmental pollution -- Chapter. 8. Main green nanomaterials to water remediation -- Chapter. 9. Green non-carbon-based nanomaterials to environs remediation -- Chapter. 10. Green Iron nanoparticles for nanoremediation -- Chapter. 11. Green Silver nanoparticles for nanoremediation -- Part III: Conjugating nanoremediation to other remediation strategies -- Chapter. 12. Green-based nanomaterial and plants in nanophytoremediation strategies -- Chapter. 13. Main interactions of green nanomaterials and microorganisms on nanoremediation protocols -- Part. IV: Safety aspects and analysis of nanoremediation -- Chapter. 14. Supporting nanotechnology safety through nanoinformatics -- Chapter. 15. Conventional strategies of environmental pollution remediation versus Green Nanoremediation -- Chapter. 16. Using nanoremediation strategies: cost/benefit analysis -- Chapter. 17. Strategies to evaluate nanoremediation efficiency.
    Abstract: This book focuses on green nanoremediation addressing aspects related to the use of nanomaterials generated through green synthesis protocols to efficiently restore polluted environs. Nanomaterials’ characteristics such as large surface area, capacity to easily reach into contaminated sites, good reactivity, and possibility of being developed to present photocatalytic activity and/or to deal with targeted substances by chemical surface modification are useful specially to perform remediation. As an alternative to conventional physicochemical methods, the green-based synthesis protocols reject the use of harmful reagents, prevent waste production, apply renewable energy source and/or materials, and consider in first place offering the smallest negative impact possible to living beings and to the ecosystem. Green synthesis in nanotechnology field involves the use of seaweeds, bacteria, cyanobacteria, yeasts, fungi, plants (living ones, biomass, extracts) and/or bio-derived products to generate the nanomaterials. The introductory chapter will be dedicated to nanomaterials’ characteristics that enable them to be used in environmental remediation. The first part of the book will be dedicated to organic and inorganic pollution and the threats they pose to living forms; advantages, disadvantages and mechanisms of nanoremediation; comparison between conventional strategies of environmental pollution remediation and the green nanoremediation; carbon-based and non-carbon-based green nanomaterials capable of promoting environs’ remediation; cost/benefits of using nanomaterials and nanoinformatics to a safe nanotechnology. The second part will be dedicated to green nanoremediation of water and soil, microbe-based, algae-based and plant-based synthesis of nanomaterials to nanoremediation. This part will also contain chapters dedicated to relevant nanomaterials for green nanoremediation protocols, nano-phytoremediation strategies, strategies to evaluate the efficiency of protocols related to this kind of remediation, main interactions of green nanomaterials and microbes during nanoremediation and, as a consequence of it, biocompatibility of green nanomaterials. This book’s main purpose is to offer readers extensive knowledge on green nanoremediation as a feasible strategy to fight pollution's harmful consequences and clean environmental pollution, but also present the challenges that should be surpassed.
    Type of Medium: Online Resource
    Pages: XI, 388 p. 96 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031305580
    URL: https://doi.org/10.1007/978-3-031-30558-0
    DOI: 10.1007/978-3-031-30558-0
    DDC: 363.73
    Language: English
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  • 16
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    Online Resource
    Managing Persistent Organic Pollutants in India : Case Studies on Vapi and Surat, Gujarat (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pollution. ; Environmental policy. ; Environmental health. ; Pollution. ; Environmental Policy. ; Environmental Health.
    Description / Table of Contents: Chapter 1 – Status of POPs Pollution in India -- Chapter 2 – Regulatory framework, Policies and Programs in POPs Management in India -- Chapter 3 – POPs Associated with Plastic Waste -- Chapter 4 – Transport of POPs from Source to Sea -- Chapter 5 – Environmental Monitoring Techniques of Targeted POPs -- Chapter 6 – Environmental and health impact -- Chapter 7 – International Regulatory Frameworks and Best Practices in Management of POPs -- Chapter 8 – Overview of Use and Release Sources of the Seven New POPs -- Chapter 9 – Analysis of Gaps in Management of POPs in India -- Chapter 10 – Case Studies-Tapi and Daman Ganga River Basins in Gujarat. .
    Abstract: Persistent Organic Pollutants (POPs) are a class of chemicals that are persistent, bio accumulative and toxic (PBT), which are restricted for use under the Stockholm Convention. They adversely impact the environment, human and animal health. Most of the POPs are semi-volatile organic compounds (SVOCs) and known to have a long-range transport potential and are often deposited in colder climate and found in places away from the regions they are produced. POPs are usually hydrophobic (i.e., “water-hating”) and lipophilic (i.e., “fat-loving”) chemicals, due to which they bind to solids, particularly organic matter, and fatty tissues in both marine and terrestrial environments. As a result, POPs may move up the food chain. This book focuses on determining the sources, fate, analytical techniques of detecting POPs as well as their health impacts. It further dwells on the regulatory aspects, management of POPs, best environmental practices (BEPs), Indian and international case studies, gaps in understanding the regulatory aspects. A few key recommendations for the way forward form the concluding chapters of this book.
    Type of Medium: Online Resource
    Pages: X, 200 p. 27 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031313110
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    URL: https://doi.org/10.1007/978-3-031-31311-0
    DOI: 10.1007/978-3-031-31311-0
    DDC: 363.73
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  • 17
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    Online Resource
    Autophagy in Stem Cell Maintenance and Differentiation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    URL: https://doi.org/10.1007/978-3-031-17362-2
    DOI: 10.1007/978-3-031-17362-2
    DDC: 571.978
    Language: English
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  • 18
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    Online Resource
    Methods in Cancer Stem Cell Biology (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biology Technique. ; Stem cells. ; Cancer Biology. ; Biological Techniques. ; Cancer Stem Cells. ; Stem Cell Biology.
    Description / Table of Contents: 1. On the origin of cancer -- 2. Culture of Cells: Basic Principles -- 3. Stem cell culture from embryos -- 4. Reprogramming of normal cells -- 5. Maintenance of human Pluripotent Stem Cells -- 6. Identification of cancer stem cells by different molecular markers -- 7. Enrichment of Cancer Stem Cell from malignant tumor -- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line -- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells -- 10. Quick method to assess non-mutagenic carcinogens with iPS cells -- 11. Self-renewal potential of caner stem cells -- 12. Differentiation potential of cancer stem cells in vitro -- 13. Tumor Angiogenesis by cancer stem cells in vivo -- 14. Invasion and Metastatic potential of cancer stem cells in vitro -- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro -- 17. Tumorigenic potential of cancer stem cells in vivo -- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells -- 19. In-vitro evaluation of anti-cancer stem cell drugs -- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
    Abstract: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters if this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. .
    Type of Medium: Online Resource
    Pages: XVII, 243 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913312
    URL: https://doi.org/10.1007/978-981-99-1331-2
    DOI: 10.1007/978-981-99-1331-2
    DDC: 571.978
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  • 19
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    Online Resource
    Hypoxia in Cancer: Significance and Impact on Cancer Therapy (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.
    Abstract: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
    Type of Medium: Online Resource
    Pages: XV, 447 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903139
    URL: https://doi.org/10.1007/978-981-99-0313-9
    DOI: 10.1007/978-981-99-0313-9
    DDC: 571.978
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  • 20
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    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
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  • 21
    Online Resource
    Online Resource
    Genetics and Epigenetics of Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    URL: https://doi.org/10.1007/978-981-19-9925-3
    DOI: 10.1007/978-981-19-9925-3
    DDC: 571.978
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  • 22
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    Online Resource
    Cancer Stem Cells: Basic Concept and Therapeutic Implications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    URL: https://doi.org/10.1007/978-981-99-3185-9
    DOI: 10.1007/978-981-99-3185-9
    DDC: 571.978
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  • 23
    Online Resource
    Online Resource
    Cytokine and Chemokine Networks in Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Immunological aspects. ; Therapeutics. ; Cancers. ; Tumour Immunology. ; Therapeutics.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy.
    Abstract: Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
    Type of Medium: Online Resource
    Pages: XVII, 440 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819946570
    URL: https://doi.org/10.1007/978-981-99-4657-0
    DOI: 10.1007/978-981-99-4657-0
    DDC: 571.978
    Language: English
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  • 24
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    Online Resource
    Redox Regulation and Therapeutic Approaches in Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    URL: https://doi.org/10.1007/978-981-99-7342-2
    DOI: 10.1007/978-981-99-7342-2
    DDC: 571.978
    Language: English
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  • 25
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    Online Resource
    Formation Mechanism and Control Strategies of Haze in China (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Pollution. ; Environmental chemistry. ; Inorganic chemistry. ; Environmental sciences Mathematics. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Chemical processes. ; Pollution. ; Environmental Chemistry. ; Inorganic Chemistry. ; Mathematical Applications in Environmental Science. ; Fossil Fuel. ; Process Chemistry.
    Description / Table of Contents: Introduction -- Atmospheric oxidation and secondary particle formation -- Haze Source Tracing -- Numerical Model of Atmospheric Haze -- Research and Development, Industrialization, and Application of Advanced Instruments -- Multi-Pollutant Collaborative Treatment Technology and Special Equipment of Atmospheric Haze.
    Abstract: This book summarizes the new major research findings about formation mechanism and control strategies of haze in China, including basic theories, key technologies, equipment and platforms and the applications and implementations of control technologies, in implementing the Strategic Priority Research Program (Class B) of Chinese Academy of Sciences. Different types of air pollution processes experienced by the developed countries in different stages are out-breaking simultaneously in China in the recent years and resulting a new type of “haze chemistry smog” pollution, which is different from the “London smog” and the “Los Angeles photochemical smog”. This book provides a useful reference for related researchers, engineers and policy-makers engaged in atmospheric pollution research, prevention and control in China and other countries.
    Type of Medium: Online Resource
    Pages: XV, 250 p. 122 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811969560
    Series Statement: Advanced Topics in Science and Technology in China, 66
    URL: https://doi.org/10.1007/978-981-19-6956-0
    DOI: 10.1007/978-981-19-6956-0
    DDC: 363.73
    Language: English
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  • 26
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    Online Resource
    Micro and Nanoplastics in Soil : Threats to Plant-Based Food (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Soil science. ; Botany. ; Pollution. ; Soil Science. ; Plant Science.
    Description / Table of Contents: Part1. Soil Pollution by Micro and Nanoplastics -- Chapter1. Soil Pollution by Micro and Nanoplastics: An overview -- Chapter2. Soil Pollution by Micro and Nanoplastics: Sources, Fate and Impact -- Chapter3. Abundance and Distribution of MPs and NPs in Soil – A Global Scenario -- Chapter4. Methodology of assessing micro plastics and nano plastics in the environment -Recent advances in the practical approaches -- Chapter5. Persistence of Micro and Nanoplastics in Soil -- Chapter6. Microplastics as a carrier of antibiotic resistance genes - a revision of literatureiz -- Part2. Trophic transfer of Micro and Nanoplastics -- Chapter7. Phytoaccumulation of Micro and Nanoplastics: Root Uptake -- Part3. Toxicity of Micro and Nanoplastics -- Chapter8. Toxicity Effects of Micro and Nanoplastics in Terrestrial Environment -- Chapter9. Ecological Impacts and Toxicity of Micro and Nanoplastics in Agroecosystem -- Chapter10. Micro and Nanoplastics on Plant Functionalities -- Chapter11. Cellular and Animal Toxicities of Micro and Nanoplastics -- Part4. Bioremediation of Micro and Nano plastics- polluted soil -- Chapter12. Restoration of Micro/Nanoplastics-contaminated Soil by Phytoremediation -- Chapter13. Bacterial Remediation of Micro/Nanoplastics-contaminated soil -- Chapter14. Mycoremediation of Micro and Nano Plastics (MNPs) – contaminated Soils -- Chapter15. Emerging Techniques for the Mitigation of Micro and Nanoplastics in Soil -- Chapter16. Micro and Nanoplastics in Agricultural Soils: Challenges and Future directions.
    Abstract: This contributed volume gives a state-of-the-art overview of microplastics and nanoplastics (MPs and NPs) in soils and their relationship with growing plants. Through chapters contributed by a wide variety of researchers, the book offers readers an understanding of MP and NP adsorption, uptake, and effects, as well as implications for trophic transmission, food safety, and security. Cutting-edge topics such as trophic transfer and remediation of MPs and NPs in soil samples are also addressed. The book begins with a primer on terrestrial MPs and NPs, their effects on terrestrial plants, and how these contaminants affect human populations. From there, the volume is split into four sections which address both problems caused by MPs and NPs in soil and potential remediation solutions. The first section deals with the mechanics of how MPs and NPs pollute soils and how toxic chemicals affect the soil profile and its flora, fauna and microbes. The second section of the book discusses trophic transfer of MPs and NPs from roots to shoot, shoot to leaves, and then to fruits. The third section details the threats to humans that are present as a result of MPs and NPs in soils. The fourth and last section gives covers bioremediation techniques that can be employed in order to reclaim polluted soils.
    Type of Medium: Online Resource
    Pages: XX, 431 p. 58 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031211959
    URL: https://doi.org/10.1007/978-3-031-21195-9
    DOI: 10.1007/978-3-031-21195-9
    DDC: 363.73
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  • 27
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    Online Resource
    Sustainable Advanced Technologies for Industrial Pollution Control : Proceedings of ATIPC 2022 (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pollution. ; Sustainability. ; Refuse and refuse disposal. ; Industrial policy. ; Pollution. ; Sustainability. ; Waste Management/Waste Technology. ; Regulation and Industrial Policy.
    Description / Table of Contents: Chapter 1: Water decontamination through Thiamethoxam removal using DL menthol-octanoic acid Deep Eutectic Solvent : Molecular dynamics insights -- Chapter 2: Methyl Red dye abatement from aqueous solution using Calcium Ferrite and Manganese Ferrite magnetic nanocomposite: Kinetics and isotherm study -- Chapter 3: Adsorption of Fluoride onto PANI-Cl jute fibre - designing higher flow rate and initial concentration column reactor from a batch reactor -- Chapter 4: Biosynthesis of Nano Zero valent Iron (nZVI) using Shorea robusta Leaf Extract and its application in UV-assisted Photocatalytic Degradation of Methyl Orange -- Chapter 5: Method Development for detection of 2-Methylpyridine by High Performance Liquid Chromatography -- Part 2 - Industrial effluent treatment, reuse and conservation -- Chapter 6: Importance of cost functions for biological treatment of wastewater -- Chapter 7: Removal of heavy metals by Laterite soil -- Chapter 8: Removal of Methylene Blue from wastewater by Red Sandy soil-Based Alkali activated binder -- Chapter 9: Assessment and Treatment of iron from industrial wastewater using activated carbon derived from Parkia Speciosa pod -- Chapter 10: Activated Carbon developed from Phumdi biomass and Deccan Hemp for adsorption of Methylene Blue -- Chapter 11: An experimental study of Metanil Yellow dye remediation using Fe-Mn Bimetal oxide composites -- Chapter 12: Optimization of electrocoagulation process parameters using magnesium electrodes for treating pharmaceutical wastewater containing salicylic acid -- Chapter 13: Optimization of process parameters for biodegradation of Cresol by mixed bacterial culture using Response Surface Methodology -- Chapter 14: Biological degradation of Cresol containing wastewater using mixed microbial culture in presence of heavy metals -- Part 3 - Monitoring of industrial emission and control -- Chapter 15: Development of a simplistic model for the prediction of reactive air pollutants in the atmosphere -- Chapter 16: Controlling Air and Metal pollution in industrial area Singrauli, India: Role of plants -- Part 4 - Industrial solid waste management -- Chapter 17: Enhancing the dewatering ability of sludge by locally available biomass -- Chapter 18: Production of Xylose from Water Hyacinth Biomass (WHB) (lignocellulosic waste) for Xylitol production: waste to wealth -- Chapter 19: A simplistic mathematical model for two-stage Anaerobic Digestion of plastic wastes -- Part 5 - Handling and disposal of hazardous waste -- Chapter 20: Modeling migration of Cr(VI) contaminant through Clay Liner using Hydrus-3d -- Chapter 21: Electrokinetic remediation of total Chromium from contaminated soil -- Chapter 22: Low-Cost recovery of Cadmium from wastewater by soil bacteria -- Part 6 - Case Studies on industrial pollution control -- Chapter 23: Tannery waste management in India: A case study -- Chapter 24: Removal of natural organics and selected antibiotics using PAC and AL electrode: A study for Jumar River -- Chapter 25: Quantification of floating plastics using UAV images and Identification of Microplastics in Ukkadam tank -- Chapter 26: Study of wastewater treatment in Hindustan Coca-Cola plant at Khurda -- Part 7 - Innovative technologies in industrial waste management -- Chapter 27: In Vitro Performance Analysis of Ti and Zn doped Hydroxyapatite made from waste Eggshells -- Chapter 28: Production of non-toxic, non-polluting herbal soaps using plant extracts having anti-microbial activity -- Chapter 29: Decolourization of Textile Dye RR 141 using electrochemical process.
    Abstract: This proceedings volume constitutes peer-reviewed full-length papers contributed by the Authors and tailored on various thematic areas of the 3rd International Conference on “Advanced Technologies for Industrial Pollution Control” (ATIPC – 2022). The areas of research covered by these papers include but are not limited to: •Water quality monitoring and treatment in industrial area •Industrial effluent treatment, reuse and conservation •Monitoring of industrial emission and control •Industrial solid waste management •Handling and disposal of hazardous waste •Case Studies on industrial pollution control •Innovative technologies in industrial waste management.
    Type of Medium: Online Resource
    Pages: XVI, 408 p. 232 illus., 175 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031375965
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    URL: https://doi.org/10.1007/978-3-031-37596-5
    DOI: 10.1007/978-3-031-37596-5
    DDC: 363.73
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    Mercury Toxicity : Challenges and Solutions (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Environmental health. ; Environmental management. ; Sustainability. ; Pollution. ; Environmental Health. ; Environmental Management. ; Sustainability.
    Description / Table of Contents: Chapter 1. Environmental Mercury Exposure – A Continuing Challenge -- Chapter 2. Mercury Contamination in Food : An Overview -- Chapter 3. Research Trend on Mercury (Hg) Contamination of Water Resources: A Bibliometric Review -- Chapter 4. Impact of mercury and its toxicity on health and environment: a general perspective -- Chapter 5. Effects of Mercury: Neurological and Cellular Perspective -- Chapter 6. Mercury Adsorption using Biowaste Biochar: A Green Technology Approach -- Chapter 7. Removal of Mercury of Wastewater by Different Natural Biomasses -- Chapter 8. Microbial Remediation of Mercury: An Overview -- Chapter 9. Remediation Strategies of Environmental Mercury: An Overview of its Environmental Persistence, Associated Threats and Health Impacts -- Chapter 10. Mercury Remediation: Easing Biochar Approach -- Chapter 11. Application and Development Strategies of Nano-Adsorbents on Mercury Remediation -- Chapter 12. Amputation of Mercury from Wastewater: Perspectives of Action Methods -- Chapter 13. Environmental Mercury Toxicity and its Bioremediation -- Chapter 14. Biosorption of Mercury from Aqueous Solutions by Biosorbents.
    Abstract: This book presents mercury toxicity with respect to remediation and health issues. It covers sources of mercury contamination, its impact on human health, and prospective remediation by both bioremediation and phytoremediation with the application of recent advanced techniques such as genetic engineering and nanotechnology. Both anthropogenic activities and natural processes cause the release of mercury into different spheres of the environment resulting in severe adverse impacts. Increased anthropogenic discharge of mercury leads to disturbance in its natural biogeochemical cycle, which results in unenviable diseases and hazardous health effects. Mercury pollution is responsible for causing neurobehavioral, kidney, heart, gastrointestinal, liver, and other diseases. Many published works about the impact of mercury on health are also available worldwide; however, there is no complete understanding available on toxicological studies of mercury that covers the broader spectrum of findings ranging from sources of exposure to mercury toxicity to its remediation strategies. This book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by mercury contamination. The book also proposes solutions to contamination through multi-disciplinary approaches. The book contains three sections. The first part describes the different sources and distribution of mercury in soil and plant ecosystems. The second part explains the health risks linked to mercury toxicity. The third part addresses sustainable mercury toxicity mitigation strategies and the potential applications of recent technology in providing solutions. This book is a valuable resource to students, academics, researchers, and environmental professionals working in the field of mercury contamination.
    Type of Medium: Online Resource
    Pages: XI, 374 p. 72 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819977192
    Series Statement: Environmental Science and Engineering,
    URL: https://doi.org/10.1007/978-981-99-7719-2
    DOI: 10.1007/978-981-99-7719-2
    DDC: 363.73
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  • 29
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    Online Resource
    Xenobiotics in Urban Ecosystems : Sources, Distribution and Health Impacts (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental chemistry. ; Urban ecology (Biology). ; Industrial microbiology. ; Pollution. ; Environmental Chemistry. ; Urban Ecology. ; Industrial Microbiology.
    Description / Table of Contents: 1-Xenobiotics in the urban ecosystems: Current status and trend analysis -- 2-Urban water cycle: A potential source and sink of xenobiotics -- 3-Xenobiotics in the urban soils: Sources and environmental concerns -- 4-Major strategies for the assessment of xenobiotics in the urban soils -- 5-Advancements in the analytical techniques for precise xenobiotic assessment -- 6-Xenobiotics in urban soils: Bioavailability and threat levels -- 7-Transport and metabolism of xenobiotics in the urban ecosystem -- 8-Xenobiotics and soil microbial community in the urban ecosystem -- 9-Impact of xenobiotics on urban agriculture/crops -- 10-Xenobiotics and urban plants: impact and threat levels -- 11-Food chain contamination and impact of xenobiotics on human health -- 12-Biotransformation of xenobiotics in the urban ecosystem -- 13-Phytoremediation and xenobiotics: exploring the potential of selected plants -- 14-Remediation strategies for xenobiotics in urban soils -- 15-Socioeconomic impacts and policy measures for xenobiotics in urban ecosystems -- 16-Management and regulatory aspects of xenobiotics: Government initiatives.
    Abstract: This volume provides state-of-the-art knowledge on xenobiotics in urban ecosystems, addressing a wide range of related issues, such as xenobiotic types and chemical composition, environmental fate, remedial approaches, regulatory policies and socioeconomic impacts. The book incorporates theoretical and practical aspects pertaining to xenobiotics to assess their threat level in urban environments, while determining appropriate responses and remediation measures to curb harmful impacts and prevent future contaminations. The book will be of interest to soil scientists, ecological engineers, agriculturists, urban policymakers, students and researchers working in the field of urban agriculture and environmental sciences.
    Type of Medium: Online Resource
    Pages: XV, 433 p. 53 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031357756
    URL: https://doi.org/10.1007/978-3-031-35775-6
    DOI: 10.1007/978-3-031-35775-6
    DDC: 363.73
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    Online Resource
    Geospatial Analytics for Environmental Pollution Modeling : Analysis, Control and Management (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pollution. ; Geographic information systems. ; Environmental management. ; Pollution. ; Geographical Information System. ; Environmental Management.
    Description / Table of Contents: Chapter 1: Types of Environmental Pollution and Its Effects On The Environment and Society -- Chapter 2: Geostatistical Methods and Framework For Pollution Modelling -- Chapter 3: GIS-based Modelling for Estimation of Water Quality Parameters: A Review -- Chapter 4: Air Quality Monitoring Using Geospatial Technology and Field Sensors -- Chapter 5: Geospatial Techniques and Methods for Monitoring and Assessment of Soil Contaminants -- Chapter 6: Geospatial Modelling and Framework For the Detection and Mapping of Noise Pollution -- Chapter 7: Urban Areas and Air Pollution: Causes, Concerns and Mitigation -- Chapter 8: Constructing The Dynamics of Water Quality Parameters Using Geospatial Technology and In Situ Observations -- Chapter 9: Urban Air Quality Monitoring and Modelling Using Ground Monitoring, Remote Sensing and GIS -- Chapter 10: Assessment of Soil Contamination Using Remote Sensing and Spatial Techniques -- Chapter 11: Noise Pollution Modelling Using Gis Techniques in Srinagar City -- Chapter 12: Geostatistics Interceded Groundwater Quality Study With Emphasis on Kriging Across the Andhra Pradesh State Of India -- Chapter 13: Air Quality and Human Health -- Chapter 14: Significance of Geo-Visualization Tools For Pollution Monitoring -- Chapter 15: Environmental Pollution Control Measures And Strategies: An Overview Of Recent Developments -- Chapter 16: Environmental Legislation and Global Initiatives.
    Abstract: This book aims to provide a comprehensive study on various aspects of environmental pollution dynamics using geospatial technology and modeling techniques. The utility of geospatial technology will be demonstrated for the effective study of environmental pollution, as space and location are very important for effective environmental health surveillance. The timeliness of the work is due to the increasing relevance of geospatial technology applications in environmental health investigations. Moreover, different types of pollution are covered in detail, including air and soil, all of which are analyzed using latest Remote Sensing and GIS technology. The basics of environmental pollution and its impacts are covered in the book's first part, while the second part focuses on the use of geospatial technology in investigating and modeling various instances of environmental pollution. The third part discusses policy measures for mitigating environmental pollution hazards, using geospatial analyses and data to craft informed policy decisions. The primary audience for the book is researchers working in the field of environmental pollution with incorporation of geospatial technology, including upper-level undergraduate and graduate students taking courses in remote sensing and its environmental applications. The secondary audience is academicians, planners, environmentalists and policymakers working in the field of environment protection and management.
    Type of Medium: Online Resource
    Pages: XVII, 437 p. 120 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031453007
    URL: https://doi.org/10.1007/978-3-031-45300-7
    DOI: 10.1007/978-3-031-45300-7
    DDC: 363.73
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    Environmental Risks Posed by Microplastics in Urban Waterways (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Water. ; Hydrology. ; Pollution. ; Waste Management/Waste Technology. ; Water.
    Description / Table of Contents: Microplastics as Emerging Pollutants in Urban Waterways -- Factors Influencing MPs Presence in Urban Waterways -- Risk Associated with MPs in Urban Waterways -- Case Study—Risks Posed by MPs Presence and Transport in Brisbane River Sediments, Australia -- Practical Implications and Recommendations for Further Research.
    Abstract: This book presents comprehensive knowledge regarding the spatial and temporal distributions, influential factors, interactions with coexisting contaminants, migration behavior, and environmental risk posed by microplastics (MPs) in urban waterways. It provides a novel theoretical approach for the combined risks from MPs and coexisting contaminants, and advanced three-dimensional modeling techniques for different MPs’ dispersal and transport behaviors in urban waterways. Additionally, this book presents a scientifically robust investigation on the correlations between various influential factors and heterogeneity in relation to MP presence in river systems. The new knowledge presented would be of particular interest to readers such as urban water management professionals, urban plastic waste regulators, decision-makers, urban planners, and water environment quality model developers, as it provides practical solutions and recommendations for plastic-polluted river quality improvement from a risk management perspective.
    Type of Medium: Online Resource
    Pages: VIII, 78 p. 52 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819906284
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-981-99-0628-4
    DOI: 10.1007/978-981-99-0628-4
    DDC: 363.73
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    Online Resource
    The Systemic Effects of Advanced Cancer : A Textbook on Cancer-Associated Cachexia (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    URL: https://doi.org/10.1007/978-3-031-09518-4
    DOI: 10.1007/978-3-031-09518-4
    DDC: 571.978
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    Immuno-Oncology Crosstalk and Metabolism (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    URL: https://doi.org/10.1007/978-981-16-6226-3
    DOI: 10.1007/978-981-16-6226-3
    DDC: 571.978
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    Cancer Metastasis Through the Lymphovascular System (2022)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    URL: https://doi.org/10.1007/978-3-030-93084-4
    DOI: 10.1007/978-3-030-93084-4
    DDC: 571.978
    Language: English
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    Online Resource
    Systems Biology of MicroRNAs in Cancer (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    URL: https://doi.org/10.1007/978-3-031-08356-3
    DOI: 10.1007/978-3-031-08356-3
    DDC: 571.978
    Language: English
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    Online Resource
    The Extracellular Matrix and the Tumor Microenvironment (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    URL: https://doi.org/10.1007/978-3-030-99708-3
    DOI: 10.1007/978-3-030-99708-3
    DDC: 571.978
    Language: English
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    Online Resource
    Breast Cancer: From Bench to Personalized Medicine (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    URL: https://doi.org/10.1007/978-981-19-0197-3
    DOI: 10.1007/978-981-19-0197-3
    DDC: 571.978
    Language: English
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    Online Resource
    Paths to Clean Water Under Rapid Changing Environment in China (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environmental monitoring. ; Freshwater ecology. ; Marine ecology. ; Pollution. ; Water. ; Environmental Monitoring. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Current situation of water pollution in China -- Challenges and opportunities to treat water pollution -- Facing water pollution under rapid changing environment: China’s experiences -- Conclusion.
    Abstract: This book mainly provides the current status of water pollution faced by China under rapid changing environment and the actions that have been taken for prevention and treatment of water pollution. It points out that the water pollution situation is severe. Facing water pollution, China’s experiences include several aspects on source control and pollution interception, internal nutrient removal of sediment, ecological restoration, and water transfer policy. There exists both the opportunity and challenge for the prevention and control of water pollution in China. The book contains numerous charts and diagrams which further illustrating China’s paths to clean water.
    Type of Medium: Online Resource
    Pages: VIII, 96 p. 29 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811900914
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-981-19-0091-4
    DOI: 10.1007/978-981-19-0091-4
    DDC: 363.73
    Language: English
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    Online Resource
    Microfiber Pollution (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Building materials. ; Sustainability. ; Pollution. ; Wood, fabric, and textiles. ; Sustainability.
    Description / Table of Contents: Microfiber Pollution – A Sustainability Issue -- Microfiber Shedding of Textile Materials – Mechanism and Analysis Techniques -- Factors Influencing Microfiber Shedding – Role of Textile and Apparel Characteristics -- Domestic Laundry – A major cause of microfiber shedding -- Impact of microfiber/Microplastic pollution -- Microfiber Pollution Prevention - Mitigation Strategies and Challenges.
    Abstract: This book provides insights into microfiber pollution in textile industries that would help researchers and professionals to work from the textile point of view to mitigate the problem, and create a green sustainable future. Microplastic pollution has received great importance due to its adverse environmental and health impact. Microplastic particles are found to contaminate the ecosystem. Research has reported microplastics on seashores, in deep seas, freshwater systems including rivers and lakes, and most importantly in the air. Various land-based and water-based organisms are also contaminated with microplastics. The most serious issue is when these particles are found in the food chain and air which can reach the human system. It has been estimated that human beings can intake up to 1,21,000 microplastic particles in a year through food and inhalation. Being one of the most polluting industries, the contribution of Textile industries in microplastic pollution is extremely higher (around 35%). This book addresses the issue of microfiber/microplastic pollution cause by various techniques including home laundry and the ways to alleviate it.
    Type of Medium: Online Resource
    Pages: XV, 243 p. 53 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811941856
    Series Statement: Sustainable Textiles: Production, Processing, Manufacturing & Chemistry,
    URL: https://doi.org/10.1007/978-981-19-4185-6
    DOI: 10.1007/978-981-19-4185-6
    DDC: 363.73
    Language: English
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    Online Resource
    Rapid Refrigeration and Water Protection : Next Generation Adsorbents (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environment. ; Environmental chemistry. ; Chemistry, Technical. ; Nanotechnology. ; Pollution. ; Water. ; Environmental Sciences. ; Environmental Chemistry. ; Industrial Chemistry. ; Nanotechnology.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Towards the Development of Compact and High Efficiency Adsorption Heat Pumps -- Chapter 3 Synthesis and Characterization of Various MOFs and MOFs-Zeolite Com-posites: Water Adsorption and Rapid Cooling Production -- Chapter 4 Specific Heat Capacity of Carbon-based Composites for Adsorption Heat Pump and Desalination Applications -- Chapter 5 Characterizing Adsorbent Materials Employing Atomic Force Microscopy -- Chapter 6 Advanced Adsorbents for Ecological Applications: Water Harvesting from the Atmosphere and Recuperation Heat and Moisture in Ventilation Systems -- Chapter 7 Thermochemical Conversion of Lignocellulosic Waste to Activated Carbon: A Potential Resource for Industrial Wastewater Treatment -- Chapter 8 Carbon Nanomaterial-based Adsorbents for Water Protection -- Chapter 9 Nanoparticles-based Adsorbents for Water Pollutants Removal.
    Abstract: This book provides a cross-disciplinary, multi-scale assessment of the development of adsorption-based refrigerants and super-adsorbent-based wastewater purification. The book covers two major aspects from the 21st century, including the development of an environmentally benign adsorption cooling system and the preparation of a super-adsorbent for water purification. Although work has been published on these topics, the authors present the latest findings and introduce some new perspectives. The book is written as a reference book with contributions from global field experts and will appeal to water engineers, chemists, environmentalists, physicists, material scientists, nano-technologists, and environmental technologists.
    Type of Medium: Online Resource
    Pages: VIII, 265 p. 111 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030938451
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-3-030-93845-1
    DOI: 10.1007/978-3-030-93845-1
    DDC: 363.73
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    Organic Pollutants : Toxicity and Solutions (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Toxicology. ; Refuse and refuse disposal. ; Biotechnology. ; Pollution. ; Toxicology. ; Waste Management/Waste Technology. ; Biotechnology.
    Description / Table of Contents: Chapter 1 -- Organic pollutants: Past, present and the future. Chapter 2 -- Persistent Organic Pollutants (POPs): Sources and adverse effects to human health and Environment. Chapter 3 -- Assessment of POPs in water. Chapter 4 -- Monitoring of POPs: A Global Perspective. Chapter 5 -- Organochlorines and organophosphates: Bioaccumulation and Toxicity. Chapter 6 -- Pharmaceutical pollutants in water: Toxicity and health hazards. Chapter 7 -- Textile organic chemicals in water: Pervasive toxicity to humans and aquatic animals. Chapter 8 -- Organic toxins in cosmetic products: Quantification and risk evaluation. Chapter 9 -- Disinfectant products: toxicity and health hazards. Chapter 10 -- Obesogens and obesity: Challenges and prospects. Chapter 11 -- Pheromones: A Potential alternative to organic recalcitrant compounds. Chapter 12 -- Microplastics as carriers of organic pollutants: An overview. Chapter 13 -- Removal of POPs through degradation mechanisms by possible technologies. Chapter 14 -- Microbes assisted adsorptive removal of melanoidin from distillery effluents. Chapter 15 -- Remediation of dye effluents using algal species. Chapter 16 -- Recovery of organic nutrients through the remediation of solid waste. Chapter 17 -- Post -- consumer organic waste management and nutrients recovery through ecofriendly techniques. Chapter 18 -- Instrumental applications in the analysis of various organic pollutants.
    Abstract: This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.
    Type of Medium: Online Resource
    Pages: XVI, 600 p. 139 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030724412
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    URL: https://doi.org/10.1007/978-3-030-72441-2
    DOI: 10.1007/978-3-030-72441-2
    DDC: 363.73
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    Legacy and Emerging Contaminants in Water and Wastewater : Monitoring, Risk Assessment and Remediation Techniques (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental chemistry. ; Water. ; Hydrology. ; Public health. ; Refuse and refuse disposal. ; Environmental health. ; Pollution. ; Environmental Chemistry. ; Water. ; Public Health. ; Waste Management/Waste Technology. ; Environmental Health.
    Description / Table of Contents: Part 1: State of the science on organic micropollutants in water and wastewater -- Chapter 1-Emerging contaminants in water and wastewater: monitoring, risk assessment and remediation techniques -- Chapter 2-Legacy and emerging contaminants in water: Origin, distribution and implications for human exposure and health -- Chapter 3-Groundwater contamination by persistent organic pollutants in India- A review -- Chapter 4-Fate, Transport and Effects of Pharmaceuticals and Personal Care Products in Urban Environment -- Chapter 5-Phenoxyacid herbicides in water ecosystems- a review on their fate, risk assessment and remediation techniques -- Part 2: Monitoring of organic micropolluntants and their associated risks -- Chapter 6-Water contamination and sources of plasticizers in Asia: a review -- Chapter 7-Antifouling Strategies & Environmental Issues in Industrial Cooling Water Systems in the Marine Environment -- Chapter 8-Measuring emerging contaminants in freshwater systems -- Chapter 9-Optical Techniques in Monitoring of Persistent Organic Pollutants (POPs) in Water and Waste Water -- Part 3: Current approaches for remediation of organic micropollutants -- Chapter 10-Pharmaceuticals in Indian Aquatic Environment: Risk and Implications for Management -- Chapter 11-Suspect and Non-target Screening of Pharmaceuticals in Water and Wastewater Matrices -- Chapter 12-Human exposure and health risks -- Chapter 13-Carbamazepine Residues in Wastewater and River Water: Occurrence, Estimation of Use, and Disposal of this Drug in a Small Community in Western Kentucky, USA -- Chapter 14-Source, Treatment and Management Options of Contaminants of Emerging Concerns (CECs) in Water -- Chapter 15-Emerging Contaminants in Water: Potential Risks and Remedial Techniques -- Chapter 16-Emerging Contaminants Removal from Domestic Wastewater by Advanced Treatment Technologies -- Chapter 17-Treatment Technologies for Emerging Contaminants in Water and Wastewater -- Chapter 18-Novel strategies to treat organic micropollutants -- Chapter 19-Advanced treatment technologies to combat antibiotic resistant bacteria and antibiotic resistance genes from urban wastewater -- Chapter 20-Nanotechnology based treatment strategies for removal of antibiotic and antibiotic byproducts from waste water -- Chapter 21-Levels, sources and removal efficiency of PCDDs/PCDFs and dl-PCBs in water and wastewater in Poland and Europe under the European water directives.
    Abstract: This volume provides a collection of research findings on the distribution and risk associated with emerging contaminants (ECs) in water and wastewater across the globe, and effective remediation techniques and technologies. The book covers various monitoring techniques for ECs in water and wastewater and its related impacts on the ambient environment, and offers valuable information on cost-effective monitoring techniques and sustainable treatment technologies for ECs. The authors detail the risks and biological effects of ECs and legacy persistent organic pollutants (POPs) in freshwater and marine systems, including their adverse interactions with aquatic organisms, while also discussing the associated impacts on human health. The book comprehensively covers current research outcomes on treatment methods, cost-effectiveness, and infrastructure needs for effective removal of ECs. It will be of interest to students, researchers, and scholars in environmental science and engineering, water and wastewater, toxicology, environmental biotechnology, soil sciences, and microbial ecology.
    Type of Medium: Online Resource
    Pages: XII, 415 p. 137 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030954437
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    URL: https://doi.org/10.1007/978-3-030-95443-7
    DOI: 10.1007/978-3-030-95443-7
    DDC: 363.73
    Language: English
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    Online Resource
    Strategies and Tools for Pollutant Mitigation : Research Trends in Developing Nations (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental chemistry. ; Agriculture. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Chemistry. ; Agriculture.
    Description / Table of Contents: PartI. State of art and sustainable remediation approaches -- Chapter1. Utilizing organic wastes for probiotic and bioproduct development: a sustainable approach for management of organic waste -- Chapter2. Bioremediation as an alternative and sustainable strategy against environmental pollutants – A review on recent advances -- Chapter3. Recent developments on the application of nanomaterials in Environmental Remediation - A review -- Chapter4. Nano-Bioremediation: An Advanced Technique for Revitalizing the Tarnished Resource -- Chapter5. Application of Biochar in the remediation of contaminated soils as a viable approach for cleaner soil system – A review -- Chapter6. Vermitechnology- an eco-friendly approach for organic solid waste management and soil fertility improvement – a review -- Part2. Waste Management for a Cleaner Environment -- Chapter7. Propelling the future biofuel research: plant breeding, genomics and genetic engineering strategies for cleaner environment -- Chapter8. Microbial Approaches for Bioconversion of Agro-Industrial Wastes -- Chapter9. Contemporary approach for electronic waste management -- Chapter10. Waste recycling and the circular bioeconomy a comprehensive review of recent researches. .
    Abstract: This book offers an overview of the latest work in environmental remediation and waste management coming out of developing nations. It is split into two sections: one on state-of-the-art sustainable remediation approaches, and the other covering waste management for a cleaner environment The ten chapters in this book are structured as reviews that assimilate recent works in these areas; they provide a centralized resource for scholars in developing nations who are working in environmental remediation and waste management. The volume will be of interest to sustainability researchers, environmental engineers, industry managers and agricultural scientists.
    Type of Medium: Online Resource
    Pages: VI, 236 p. 30 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030982416
    URL: https://doi.org/10.1007/978-3-030-98241-6
    DOI: 10.1007/978-3-030-98241-6
    DDC: 363.73
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    Online Resource
    Constructed Wetlands for Wastewater Treatment in Hot and Arid Climates (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Pollution. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability.
    Description / Table of Contents: Chapter 1. Constructed wetlands as a green and sustainable technology for domestic wastewater treatment under the arid climate of rural areas in Morocco (Laila Mandi) -- Chapter 2. Efficiency of constructed wetlands and wastewater stabilization ponds for wastewater treatment in northern Algerian Sahara (Khaled Bouchama) -- Chapter 3. A review of constructed wetlands types and plants used for wastewater treatment in Egypt (Mohamed S. Gaballah) -- Chapter 4. Two decades of experience on Nature-Based Solutions for wastewater treatment in Egypt, Palestine and Tunisia (F. Masi) -- Chapter 5. Constructed Wetlands for wastewater management in Egypt: an overview of 30-years experiences in small / medium-size treatment plants (Hussein I. Abdel-Shafy) -- Chapter 6. Constructed wetland as an efficient technology for the treatment of urban/industrial wastewater in the arid regions: Morocco as a model (Ayoub El Ghadraoui) -- Chapter 7. Vertical Flow Constructed Wetlands for horticulture wastewater treatment under a hot climate in Ethiopia (Frank van DIEN) -- Chapter 8. Constructed Wetlands in a community setting in Mombasa, Kenya (Sarah den Haring) -- Chapter 9. Performance of Constructed Wetlands in a hot tropical climate: the case of Tanzania (Jamidu H.Y. Katima) -- Chapter 10. Constructed wetlands lessons from Israel, Jordan and Palestine: the effect of plants and filter media on CW performance (Hassan Azaizeh) -- Chapter 11. Performance of decentralized Vertical Flow Constructed Wetlands for reuse in agricultural irrigation in Jordan: enhancing nitrogen removal (Ghaida Abdallat) -- Chapter 12. Constructed wetlands for sustainable wastewater treatment in Oman: experiences from research and case studies (Alexandros I. Stefanakis) -- Chapter 13. Constructed Wetlands for Sustainable Wastewater Treatment – Case Studies from Pakistan (Atif Mustafa) -- Chapter 14. Constructed wetland case studies for municipal and glass industry wastewater treatment in Iran (Amir Gholipour) -- Chapter 15. Research and case studies of Sludge Treatment Wetlands in hot and arid climates: experiences and opportunities for sustainable sludge management (Alexandros I. Stefanakis) -- Chapter 16. Full-scale experiences of arid and semi-1 arid land-based decentralized constructed wetlands in India and China (Meera Keraliya) -- Chapter 17. Performance assessment of Constructed Wetland in a semi-arid region in India employing SWOT analysis (Kirti Avishek) -- Chapter 18. Novel media and unit configurations in advanced Constructed Wetlands: case studies under hot climate in Thailand (Thammarat Koottatep) -- Chapter 19. Treatment Wetlands in Atacama 1 Desert, Chile: experiences and lesson learnt from wastewater treatment and reuse (Ismael Vera-Puerto) -- Chapter 20. Wastewater Gardens systems in Yucatan, Mexico; northwest Australia; northern Algeria and southern Iraq (Mark Nelson) -- Chapter 21. Selected Constructed Wetlands case studies in Africa, Asian and Latin American countries (M.A. El-Khateeb).
    Abstract: This edited book presents the first collection of case studies and research projects on the sustainable technology of constructed wetlands for wastewater management under hot and arid climates. It is the first such work that summarizes in a single reference the current international experiences and knowledge on the implementation of this nature-based solution under these diverse and often harsh climatic conditions. It covers the relevant gap in the fragmented and limited literature by providing integrated information and documentation on the feasibility of this green technology. The book presents the treatment efficiency of constructed wetland facilities and the research output from 29 different countries across South America, Africa, Asia and Oceania, while it covers various applications such as domestic and municipal wastewater, various industrial effluents and municipal sludge. Many examples and case studies further demonstrate the potential of this technology to contribute to better address the issues of water scarcity and limited fresh water resources through circular management of treated effluents e.g. reuse in irrigation. It also discusses the various challenges and technical aspects that should be considered in such climates, along with the environmental, financial and social benefits of this technology. This work is a useful handbook and guide for professional engineers, practitioners, academics, researchers, students, and water authorities who wish to get a better understanding and first-hand information on the potential of constructed wetlands for cost-effective and sustainable wastewater management in countries with hot and arid climates.
    Type of Medium: Online Resource
    Pages: XV, 394 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031036002
    Series Statement: Wetlands: Ecology, Conservation and Management, 7
    URL: https://doi.org/10.1007/978-3-031-03600-2
    DOI: 10.1007/978-3-031-03600-2
    DDC: 363.73
    Language: English
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  • 45
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    Online Resource
    Cancer Biomarkers in Diagnosis and Therapeutics (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Tumor markers. ; Cancer. ; Cancer Treatment. ; Nanomedicine. ; Tumour Biomarkers. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Introduction to cancer biomarkers -- Chapter 2.Technologies for identification and validation of cancer biomarkers -- Chapter 3. BIOMARKERS FOR CANCER DRUG DEVELOPMENT -- Chapter 4. Clinical proteomics: diagnostics and prognostic markers of Cancer -- Chapter 5.Microbiome as cancer biomarkers -- Chapter 6. Predictive biomarkers for anticancer drugs -- Chapter 7. Biomarkers in Cancer Survival and Drug Resistance -- Chapter 8. Biomarkers in tumor recurrence and metastasis -- Chapter 9. Biomarkers for Cancer Immunotherapy -- Chapter 10. Role of Biomarkers in Personalized Medicine -- Chapter 11.Development of Novel Cancer Biomarkers for Diagnosis and Prognosis -- Chapter 12. Nanotechnology for Cancer Biomarkers.
    Abstract: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
    Type of Medium: Online Resource
    Pages: XII, 365 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811657597
    URL: https://doi.org/10.1007/978-981-16-5759-7
    DOI: 10.1007/978-981-16-5759-7
    DDC: 571.978
    Language: English
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  • 46
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    Online Resource
    Microfluidics and Biosensors in Cancer Research : Applications in Cancer Modeling and Theranostics (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    URL: https://doi.org/10.1007/978-3-031-04039-9
    DOI: 10.1007/978-3-031-04039-9
    DDC: 571.978
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  • 47
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    Online Resource
    Cancer Diagnostics and Therapeutics : Current Trends, Challenges, and Future Perspectives (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Blood-vessels. ; Blood-vessels Growth. ; Cancer Imaging. ; Cancer Genetic aspects. ; Cancer Biology. ; Tumour Angiogenesis. ; Cancer Imaging. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Part I: Basic Background -- Chapter 1. Fighting with Cancer: A Common Man’s Dilemma -- Chapter 2. Introduction to Cell Biology and Cell Behavior in Cancer -- Chapter 3. Tumor Biology: An Introduction -- Chapter 4. Role of Angiogenesis in Tumours -- Chapter 5. Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis -- Part II: Diagnostics and Theory -- Chapter 6. MRI, CT and PETSCAN: Engineer’s Perspective -- Chapter 7. Diffusion, MRI and Cancer Diagnosis: Physicist’s Outlook -- Chapter 8. Oncology: Radiation Oncologist’s View -- Chapter 9. Oncology: Biochemists’ Perspective -- Chapter 10. Oncology: Pathologist’s View -- Part III: Cancer Therapeutics -- Chapter 11. Surgical Oncology: An Overview -- Chapter 12. Medical Oncology in Cancer Treatment -- Chapter 13. Chemotherapy Effects on Immune System -- Chapter 14. Telomerase and its therapeutic implications in Cancer -- Chapter 15. Pain Management in Oncology -- Part IV: Emerging Trends in Cancer Research -- Chapter 16. New Approaches in Cancer Research: Stem-cell research, Translational Research, Immuno-therapy, and others -- Chapter 17. Cancer Cell Lines: Its Implication for Therapeutic Use -- Chapter 18. Genomics of Cancer -- Chapter 19. Chapter 19: Diabetes and Cancer -- Chapter 20. Oncology Informatics, AI, and Drug Discovery -- Chapter 21. Radiomics: Cropping More from the Images -- Part V: Epidemiology and Statistics of Cancer -- Chapter 22. Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies -- Chapter 23. Epidemiology of Cancer: Asian Perspective -- Chapter 24. Cancer Genomics and Diagnostics: Northeast Indian Scenario.
    Abstract: This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647529
    URL: https://doi.org/10.1007/978-981-16-4752-9
    DOI: 10.1007/978-981-16-4752-9
    DDC: 571.978
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  • 48
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    Online Resource
    Phytonanotechnology (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Pollution. ; Botany. ; Nanotechnology. ; Pollution. ; Plant Science. ; Nanotechnology.
    Description / Table of Contents: - Plant synthesized nanoparticles for dye degradation -- Plant-Mediated Green Synthesis of Nanoparticles for Photocatalytic Dye Degradation -- Plant-derived nanoparticles for heavy metal remediation -- Biomedical applications of phytonanotechnology -- Application of nanotechnology in plant secondary metabolites production -- Applications of Nanotechnology in Preservation and Development of the Plants: A Look Back -- Environmental applications of Phytonanotechnology: a promise to sustainable future -- Phytonanotechnological Approach for Silver Nanoparticles: Mechanistic Aspect, Properties and Reliable Heavy Metal Ion Sensing -- Plant Material Assisted Magnetic Nanoparticles (MNPs) for the Separation of Inorganic Pollutants -- Environmental Applications of Green Engineered Silver Nanoparticles -- Bioremediation of heavy metal contaminated sites using phytogenic nanoparticles -- Environmental applications of green engineered copper nanoparticles -- Plant mediated nanocomposites for water remediation -- Photocatalytic degradation of dye from various metal/metal oxides derived from diverse plants -- Phytonanotechnology for the removal of pollutants from the contaminated soil environment.
    Abstract: This book provides essential information on the role of phytonanotechnology in the removal of environmental pollutants and covers recent advances in experimental and theoretical studies on plant-derived nanoparticles. It also discusses their current and potential applications and challenges. The combination of nanotechnology and phytoremediation, which is called phytonanotechnology, have the potential to remove contaminants from the environment or degrade them. The efficiency of contaminant removal can be improved by combining both methods as they are complementary to each other. Phytonanotechnology offers the advantages of increased bioavailability, prolongation of heavy metal absorption time, and multiple metal removal, all contributing to improved efficacy and decreased toxicity in plants and surroundings. Therefore, there is immense scope for nature-derived molecules to be formulated into nanotechnology-based phytoremediation approaches targeting the specific heavy metal removal from effluents and surroundings. This encourages research initiatives to synthesize more phytonanotechnology based uptake plant systems with high efficiency. Efficient formulation targeting strategies and the evaluation of targeting efficiency of phytonanotechnology, conforming to international standards of their toxicology and biocompatibility, could pave the way for heavy metal uptake and removal by plant-based systems. This book serves as a valuable resource for postgraduate students, environmental scientists and materials scientists in academia and corporate research. .
    Type of Medium: Online Resource
    Pages: VI, 336 p. 54 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811948114
    URL: https://doi.org/10.1007/978-981-19-4811-4
    DOI: 10.1007/978-981-19-4811-4
    DDC: 363.73
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    Hazardous Environmental Micro-pollutants, Health Impacts and Allied Treatment Technologies (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Diseases. ; Medicinal chemistry. ; Medical microbiology. ; Pollution. ; Diseases. ; Medicinal Chemistry. ; Medical Microbiology.
    Description / Table of Contents: Chapter 1-Environmental Micropollutants -- Chapter 2-Infectious Diseases, Challenges and their Impacts on Human Health under Changing Climate -- Chapter 3-Marble Dust as an Environmental and Occupational Hazard -- Chapter 4-Impacts of Micropollutants on Economy and Main Spheres of Environment: Soil, Air and Water -- Chapter 5-Micropollutants Impacts and Preventive Measures to Reduce Diseases Burden among School Children -- Chapter 6-Emerging Organic Contaminants, Pharmaceuticals and Personal Care Products (PPCPs): A Threat to Water Quality -- Chapter 7-Environmental and Health Effects of Heavy Metals and their Treatment Methods -- Chapter 8-Organophosphates Pollution Status and their Remediation through Microbial Interaction in 21st Century -- Chapter 9-Atmospheric Toxic Organic Micropollutants -- Chapter 10-Impact of Aerial Fungal Spores on Human Health -- Chapter 11-Health Risks Associated with Arsenic Contamination and its Biotransformation Mechanisms in Environment: A Review -- Chapter 12-E-waste Threaten to Environment and Public Health -- Chapter 13-Manufacturing and use of flame retardant chemicals and their impact on the environment and public health -- Chapter 14-Mycotoxins in Environment and Its Health Implications -- Chapter 15-Antibiotics; Multipronged Threat to Our Environment -- Chapter 16-Microplastic pollution and Their Health Impacts -- Chapter 17-Treatment Technologies for the Environmental Micropollutant.
    Abstract: This volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks. The book features chapters that cover a variety of topics related to environmental micropollutants, which include dusts, infectious particles, heavy metals, organophosphates, atmospheric toxic organic micropollutants, fungal spores, pollutants from E-waste, antibiotic waste, and more. In addition impacts on human health and the environment, economic issues are addressed, with potential policy solutions offered. This work is timely, as hazardous micropollutants in soil, water and air are becoming more common, and this environmental contamination is leading to increasing instances of suboptimal human health outcomes. The book will be of interest to students and researchers in environmental pollution and remediation technology, microbiologists, and environmental regulators. .
    Type of Medium: Online Resource
    Pages: VIII, 401 p. 35 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030965235
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    URL: https://doi.org/10.1007/978-3-030-96523-5
    DOI: 10.1007/978-3-030-96523-5
    DDC: 363.73
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  • 50
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    Online Resource
    Safe Water and Sanitation for a Healthier World : A Global View of Progress Towards SDG 6 (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Medical policy. ; Pollution. ; Water. ; Water. ; Health Policy.
    Description / Table of Contents: Chapter 1 -- Introduction. Chapter 2 -- Possibilities and scenarios for the fulfillment of the SDGs of water and sanitation in Latin America. Chapter 3 -- The challenges and opportunities of financing the water and sanitation sector from the perspective of meeting the SDG 6 targets in Africa. Chapter 4 -- Gaps and Opportunities in reaching SDG6 targets in Russia. Chapter 5 -- Water and sanitation developments in China. Chapter 6 -- Readiness of Solomon Islands in meeting SDGs in water and sanitation. Chapter 7 -- National WATSAN targets and milestones towards achieving SDG 6 by 2030 in Sri Lanka. Chapter 8 -- Investigating measures to get the Caribbean Region on track to meet water and sanitation targets by 2030. Chapter 9 -- Problems facing developed countries: the case of Australia. Chapter 10 -- Water and health in remote Indigenous communities in developed countries. Chapter 11 -- Sustainable safe water and sanitation interventions in remote Ghanaian Communities. Chapter 12 -- Sanitation in transition: Prospects for a sustainable sanitation business. Chapter 13 -- SDG6 and its interlinkages with other SDGs and integrating SDGs in policy and practice: Uganda case study. Chapter 14 -- Conclusion and beyond 2030.
    Abstract: This volume presents a review of global progress made towards achieving Sustainable Development Goal 6 (SDG 6): Clean Water and Sanitation, part of the United Nations 2030 Agenda for Sustainable Development. It builds on the latest data and statistics provided by the UN and other international organizations through chapters written by a wide variety of authors, including representatives of government ministries and departments, members of international organizations specializing in this area, academics and senior professionals. The book details how SDG 6 is being approached in a number of geographic regions, with each chapter describing developments in a particular region or country. Supporting case studies presented in the book illustrate progress, achievements and challenges that remain in the effort to reach SDG 6 by 2030. The book is intended for academics/researchers, scientists, policymakers, practitioners, and all stakeholders working at the global, regional, national and local levels who support or are engaged with the implementation of SDG 6.
    Type of Medium: Online Resource
    Pages: IX, 232 p. 66 illus., 65 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030940201
    Series Statement: Sustainable Development Goals Series,
    URL: https://doi.org/10.1007/978-3-030-94020-1
    DOI: 10.1007/978-3-030-94020-1
    DDC: 363.73
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    Microplastics Pollution in Aquatic Media : Occurrence, Detection, and Removal (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Sustainability. ; Environmental management. ; Pollution. ; Water. ; Sustainability. ; Environmental Management.
    Description / Table of Contents: Microplastics Occurrence in Different Regions Around the World -- Microplastics pollution in rivers -- Microplastics in freshwater environments and drinking water -- The role of rivers in microplastics spread and pollution -- Microplastics pollution in coastal zones -- A Critical Review on Separation, Identification, Quantification and Removal of Microplastics in Environmental samples: Developments and Challenges -- Pretreatment methods for further analysis of microplastics in wastewater and sludge samples -- Microplastics Sampling and Recovery: Materials, Identification, Characterization Methods and Challenges -- Ecotoxicity assessment of microplastics on aquatic life -- Occurrence, fate and removal of microplastics in wastewater treatment plants (WWTPs) and drinking water treatment plants (DWTPs) -- Microplastic pollution in water and their removal in various wastewater treatment plants -- An Overview of Physical, Chemical and Biological Methods for Removal of Microplastics -- Microplastics and anaerobic digestion -- Role Of Microplastics As Attachment Media For The Growth Of Microorganisms.
    Abstract: This book highlights one of the most important water pollutants known as Microplastics. It has been reported that humans and the environment are dealing with microplastics particles in water and aquatic media. Despite the fact that such pollution might have mainly started out from the sea, it is now in lakes, rivers, ponds and even drinking water. This book presents as overview of microplastics in freshwater environments in different regions around the world. It discusses the ecotoxicological effects of microplastics, the removal/remediation techniques of microplastics and the role of water/wastewater treatment plants in spreading microplastics. This book is a valuable resource, covering wide aspects of microplastics from sources, detection and characterization to removal and their fate in treatment plants.
    Type of Medium: Online Resource
    Pages: VIII, 377 p. 59 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811684401
    Series Statement: Environmental Footprints and Eco-design of Products and Processes,
    URL: https://doi.org/10.1007/978-981-16-8440-1
    DOI: 10.1007/978-981-16-8440-1
    DDC: 363.73
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  • 52
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    Microplastic Pollution : Environmental Occurrence and Treatment Technologies (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental health. ; Refuse and refuse disposal. ; Environmental chemistry. ; Pollution. ; Environmental Health. ; Waste Management/Waste Technology. ; Environmental Chemistry.
    Description / Table of Contents: Part1. Introduction to Plastic pollution -- Chapter1. Emerging issue of Microplastic in Sediments and Surface water of South Asia: A Review of Status, Research Needs and Data Gaps -- Chapter2. Extraction, Enumeration and Identification Methods for Monitoring Microplastics in the Aquatic Environment -- Chapter3. Monitoring of Microplastic Pollution -- Chapter4. Polymer types of microplastic in coastal areas -- Chapter5. Evaluation of Different Metrics to Study Microplastics as an Environmental Forensic Tool -- Part2. Environmental Occurrence -- Chapter6. Atmospheric microplastic distribution, fate, and behaviour in context to pollution -- Chapter7. Microplastic Pollution in the Context of Occurrence, Distribution, Composition, and Concentration in Surface Waters and Sediments: A Global Overview -- Chapter8. Microplastic Pollution in the Black Sea: An Overview of the Current Situation -- Chapter9. Occurrence and fate of microplastics in freshwater resources -- Chapter10. Occurrence of microplastic pollution in freshwater -- Chapter11. Occurrence of Microplastic Pollution in Coastal Areas -- Chapter12. Modeling the fate and transport of microplastics in coastal areas -- Chapter13. Occurrence of microplastic pollution in marine water -- Part III. Risk assessment and health impact -- Chapter14. Microplastic Pollution and Contamination of Seafood (including fish, sharks, mussels, oysters, shrimps, and seaweeds): A Global Overview -- Chapter15. Impacts of Plasticizers on Riverine Ecological Integrity in Context to Sustainability Challenges -- Chapter16. Consequences of Plastic Trash on Behavior and Ecology of Birds -- Chapter17. Risk assessment of microplastic pollution -- Chapter18. The ecotoxicological effects of microplastics on trophic levels of aquatic ecosystems -- Chapter19. Ecological and public health effects of microplastics pollution -- PartIV. Treatment Technologies -- Chapter20. Microplastics as an emerged contaminant and its potential treatment technologies -- Chapter21. Green treatment technologies for microplastic pollution -- Chapter22. Chemical Technologies to degrade microplastic pollution -- Chapter23. Bibliometric Analysis of Emerging Trends in Research on Microplastic Pollution in Post-Paris Agreement and Post-COVID-19 Pandemic World.
    Abstract: This volume discusses the growing issue of global environmental microplastic pollution resulting from the industrial manufacturing of everyday products. The book focuses on the emergence of microplastic pollution, types, sources, fate, dynamic trends in the environment, occurrence in different environmental settings, toxicity, risk assessment, and prevention strategies. The authors provide a detailed explanation and provision of the techniques used for the detection, separation, and identification of microplastics for use by industry workers and scientists, along with policy recommendations for legislative bodies to reduce the spread and impact of harmful microplastics. The book will be of use to students, teachers, researchers, policy makers, and environmental organizations.
    Type of Medium: Online Resource
    Pages: XIII, 550 p. 77 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030892203
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    URL: https://doi.org/10.1007/978-3-030-89220-3
    DOI: 10.1007/978-3-030-89220-3
    DDC: 363.73
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  • 53
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    Social Constructions of Water Quality in South Africa : A case study of the Blesbokspruit River in the Context of Acid Mine Drainage Treatment (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental health. ; Environmental sciences Social aspects. ; Economic development. ; Pollution. ; Environmental Health. ; Environmental Social Sciences. ; Development Studies.
    Description / Table of Contents: Section1. Forest Conservation Ecology -- Chapter1. Introduction to Forest Resources in India: Conservation, Management, and Monitoring Perspectives -- Chapter2. Assessment of Carbon Sequestration using InVEST model in Delhi, India -- Chapter3. Assessments of Bio-physical characteristics of Vegetation cover in Western Part of Puruliya District in West Bengal -- Chapter4. Delineating the mangrove patches along coastal Kerala using Geographical Information System, satellite data and field validation -- Section2. Forest Conservation and Society -- Chapter5. Significance of Social Systems in Forest and Biodiversity Conservation: Experiences from JANGAL MAHALS of West Bengal, India -- Chapter6. ‘Green placemaking’ in Kolkata: Role of Urban Greens and Urban Forestry -- Chapter7. Forest Resource Scenario in Industrial Town: A Study of Asansol-Durgapur Region -- Chapter8. Floristic composition and inventorization of forest resources in some selected forest areas of Paschim Bardhaman district, West Bengal, India -- Section3. Forest Management -- Chapter9. Assessment of Forest cover change, community responses and conservation strategy: Evidence from North Sikkim district, India -- Chapter10. Carbon stock assessment in sub-humid tropical forest stands of the Eastern Himalayan foothills -- Chapter11. A People’s Biodiversity Register of Henry’s Island, Indian Sundarban -- Chapter12. Applications of Geospatial Technology on the Forest Management in Three Districts of North Bengal, India -- Section4. Forest Monitoring using GIS and Remote Sensing -- Chapter13. An assessment of the temporal changes in land cover and forest fragmentation using geospatial techniques: A case study from the Central Indian Highlands -- Chapter14. Analyzing the Trend, Pattern, and Hotspots of Forest Fires Using Geospatial Techniques: A Case Study of Almora District, India -- Chapter15. Approaches and methodologies on mapping vegetation cover and biodiversity status using remote sensing and spatial analysis: A systematic review -- Chapter16. Application of participatory rural appraisal and geospatial techniques for analyzing the dynamics of mangrove forest and dependent livelihood in Indian Sundarban -- Section5. Human-Wildlife Conflicts -- Chapter17. Changing landscape and escalating human-wildlife conflict: Introspection from a transboundary landscape -- Chapter18. Issues of Biodiversity Conservation and Conflict in Gorumara National Park, West Bengal, India -- Chapter19. Assessing potential Habitat suitability for Panthera tigris using multiple grain size and different ensemble methods in maximum entropy modeling -- Chapter20. Assessment of Prospective Check Dam Sites in Kaimur Wildlife Sanctuary, Bihar with Integrated Analytical Hierarchy Process and Geospatial Techniques.
    Abstract: This book details how the water quality of the Blesbokspruit River in Gauteng, South Africa was socially constructed by stakeholders and key individuals in the context of acid mine drainage (AMD) and its treatment. Social constructionism is used as the framing for this research to explain how water is intrinsically social. Findings presented here show that stakeholders are aware that the changes in the physicality of the Blesbokspruit resulted from human interventions and varied uses of the water over the years. Such knowledge, among factors such as the historical context of mining, current coal mining, flows and volumes of water, technology used and processes followed, information and communication, and vested interests influence social constructions of the water quality. What counts as the truth about water varies depending on the individual’s perspective, their purpose, and their individual interests. Further, how one defines water quality influences what treatment processes are preferred in order to improve water quality. The book explains why, for example, a treatment process meant to improve water quality gained a bad reputation by the public because of the South African government’s silo approach. The book explains how these social constructions are entrenched in power relations between stakeholders regarding AMD treatment and illustrates how power was used to influence decisions to improve the water quality of the Blesbokspruit. The case presented in this book offers insights and recommendations for policymakers working in water governance, including means to influence social constructions of water quality and ways to clarify roles and responsibilities in pursuit of improved cooperative government.
    Type of Medium: Online Resource
    Pages: XVIII, 219 p. 38 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030982379
    URL: https://doi.org/10.1007/978-3-030-98237-9
    DOI: 10.1007/978-3-030-98237-9
    DDC: 363.73
    Language: English
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    Online Resource
    Environmental Strategy and Planning in China (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental management. ; Environmental health. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Management. ; Environmental Health.
    Description / Table of Contents: Watershed Eco-compensation in China: Practice and Review -- Practices of Emission Trading in China: Exploration and Innovation -- Chinese Environmental Audit System for the Government -- China’s Carbon Tax Impact on Economy and Society: A Static Computable General Equilibrium Analysis -- Urban Rural Environmental Master Planning: An Instrument for Sustainable Spatial Management -- Synergies between Biodiversity Conservation and Poverty Alleviation in China -- Developing Indicators and Monitoring Systems for Environmentally Livable Cities in China -- An Analysis of Disease Burden Attributable to Urban Air Pollution in the Context of Population Ageing in China from 2010 to 2030 -- China’s Green Financial Policies 2016 -- Research on Economic Policies for Centralized Disposal of Medical Waste -- Formulation of the Belt and Road Ecological and Environmental Cooperation Plan -- Study on Electricity Substitution Plan for Residential Bulk Coal in Beijing-Tianjin-Hebei Region.
    Abstract: This book covers the research fields in biodiversity conservation, the Belt and Road eco-environmental cooperation, China's five-year plan for eco-environmental protection, sustainable development goals assessment, and human health loss assessment. In the past, these achievements have played an important scientific role in supporting China's ecological and environmental protection, and produced extensive social impacts and significant environmental benefits. At the same time, the relevant research ideas and methods also show the latest progress and trend in the field of environmental strategy and planning in China in recent years, which can be used for reference by experts and scholars of other countries in the field of ecological environment.
    Type of Medium: Online Resource
    Pages: VIII, 251 p. 77 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811669095
    URL: https://doi.org/10.1007/978-981-16-6909-5
    DOI: 10.1007/978-981-16-6909-5
    DDC: 363.73
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    Lipid Metabolism in Tumor Immunity (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    URL: https://doi.org/10.1007/978-981-33-6785-2
    DOI: 10.1007/978-981-33-6785-2
    DDC: 571.978
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    Tumor Microenvironment : Signaling Pathways – Part B (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    URL: https://doi.org/10.1007/978-3-030-47189-7
    DOI: 10.1007/978-3-030-47189-7
    DDC: 571.978
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    Online Resource
    Cancer Biology: How Science Works (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    URL: https://doi.org/10.1007/978-3-030-75699-4
    DOI: 10.1007/978-3-030-75699-4
    DDC: 571.978
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    Obesity and Cancer (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    URL: https://doi.org/10.1007/978-981-16-1846-8
    DOI: 10.1007/978-981-16-1846-8
    DDC: 571.978
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    Skin Cancer: Pathogenesis and Diagnosis (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.
    Abstract: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603648
    URL: https://doi.org/10.1007/978-981-16-0364-8
    DOI: 10.1007/978-981-16-0364-8
    DDC: 571.978
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    Genetic Polymorphism and cancer susceptibility (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.
    Abstract: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
    Type of Medium: Online Resource
    Pages: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366992
    URL: https://doi.org/10.1007/978-981-33-6699-2
    DOI: 10.1007/978-981-33-6699-2
    DDC: 571.978
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    Dietary Research and Cancer (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    URL: https://doi.org/10.1007/978-981-16-6050-4
    DOI: 10.1007/978-981-16-6050-4
    DDC: 571.978
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    Anoikis : How the Extracellular Matrix Regulates Life-or-Death Decisions (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    URL: https://doi.org/10.1007/978-3-030-73856-3
    DOI: 10.1007/978-3-030-73856-3
    DDC: 571.978
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    Inflammation, Infection, and Microbiome in Cancers : Evidence, Mechanisms, and Implications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-67951-4
    DOI: 10.1007/978-3-030-67951-4
    DDC: 571.978
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    Water Resources Management of the People’s Republic of China : Framework, Reform and Implementation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environmental management. ; Energy policy. ; Energy and state. ; Pollution. ; Water. ; Environmental Management. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Chapter 1. Physical settings and water challenges -- Chapter 2. Water resources management framework -- Chapter 3. Water resources management institutions -- Chapter 4. River basin management -- Chapter 5. Water resources allocation and regulation -- Chapter 6. Water rights system -- Chapter 7. Water pricing -- Chapter 8. Groundwater management -- Chapter 9 Water quality management -- Chapter 10. Recycled water use management -- Chapter 11. The strictest water resources management strategy and three redlines -- Chapter 12 River and lake leadership system -- Chapter 13. Water resources asset management -- Chapter 14. Water resources allocation and regulation in Yellow River basin -- Chapter 15. Agricultural water management in northern China -- Chapter 16 Integrated urban and rural water affair management reform: Shanghai and Beijing -- Chapter 17 -- Environmental flow definition and management: a case study of Jiaojiang River -- Chapter 18. Climate change and water resources -- Chapter 19 Conclusions and outlook.
    Abstract: This book explores water resources management issues in China and possible solutions. It analyzes a wide range of general and specific topics, providing case studies and a balanced review of the past and present situation as well as future developments. The book begins with a general introduction and an overview of hydrology, water resources, and development issues in China. It then presents a management framework, including a management system, management institutions, river basin management, water pricing, water rights, and groundwater management, and discusses its implementation, covering water resources allocation and regulation in the Yellow River, integrated water affair management reforms, and agricultural water management in northern China. The last section focuses on the current reforms and hot topics, with strong emphasis on stringent water resource strategies applied to the river and lake principle system, recycled water use and water resources asset management, as well as climate change impacts, and concludes with a summary of the many changes in the water sector in China and a look at the road ahead and the areas that still need to be reformed.
    Type of Medium: Online Resource
    Pages: XIX, 455 p. 42 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030619312
    Series Statement: Global Issues in Water Policy, 26
    URL: https://doi.org/10.1007/978-3-030-61931-2
    DOI: 10.1007/978-3-030-61931-2
    DDC: 363.73
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    Online Resource
    Bioenergy Research: Basic and Advanced Concepts (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental chemistry. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Engineering/Biotechnology. ; Environmental Chemistry.
    Description / Table of Contents: 1 Downstream Processing of Biofuels -- 2 Application of Micro-organisms for Biofuel Production -- 3 Influence of Significant Parameters on Cellulase Production by Solid State Fermentation -- 4 Influence of Xenobiotics on Fungal Ligninolytic Enzymes -- 5 Challenges in Bioethanol Production; Effect of Inhibitory Compounds -- 6 Engineering of Zymomonas Mobilis for enhanced Biofuel production -- 7 Sustainable Production of Hydrogen by Algae: Current Status and Future Perspectives -- 8 Bioprocess Parameters for Thermophilic and Mesophilic Biogas Production: Recent Trends and Challenges -- 9 Microbial and Bioinformatics Approach in Biofuel Production -- 10 Substrate Characterization in the Anaerobic Digestion Process. .
    Abstract: This volume is first part of the five-part set on bioenergy research. This volume covers current developments and both basic and advanced concepts in bioenergy production. Based on bioenergy road map, the book will also evaluate about the ratio existing between current challenges associated and practical implementation of these biofuels. The book complies up to-date progressive development in available bioenergy options and discusses opportunities and existing risks. The main objective of the book is to provide insights into the opportunities and required actions for the development of an economically viable bioenergy industry for practical replacement of fossil fuels. This book is of interest to teachers, researchers, scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of environmental sciences. National and international bioenergy scientists, policy makers will also find this to be a useful read. Other four volumes of this set explore latest developments, commercial opportunities, waste to energy and integrated solution for bioenergy concerns.
    Type of Medium: Online Resource
    Pages: XII, 342 p. 82 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813346116
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-33-4611-6
    DOI: 10.1007/978-981-33-4611-6
    DDC: 363.73
    Language: English
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    Online Resource
    Water Pollution and Management Practices (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental monitoring. ; Environmental management. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Monitoring. ; Environmental Management.
    Description / Table of Contents: Chapter 1. Microbial Contamination of Drinking Water -- Chapter 2. Landscape Perspective to River Pollution: A Case Study of Bentong River, Malaysia -- Chapter 3. Existence of Antibiotics in Waste Water as a Pollution Indicator -- Chapter 4. Application of Artificial Intelligence in Predicting Groundwater Contaminants -- Chapter 5. Arsenic Contamination of Ground Water and its Mitigation Strategies -- Chapter 6. Wastewater Reuse in Peri-Urban Agriculture Ecosystem: Current Scenario, Consequences and Control Measures -- Chapter 7. Nitrogenous wastes and its efficient treatment in wastewater -- Chapter 8. Application of Waste Water In Irrigation and Its Regulation with Special reference to Agriculture Residues -- Chapter 9. Riparian Ecotones-An Important Derivative Of Managing The River Pollution -- Chapter 10. Ecosystem Responses to Pollution in the Ganga River: Key Issues to Address River Management -- Chapter 11. An Overview on Heavy metal Contamination of Water System and Sustainable Approach for Remediation -- Chapter 12. An Overview of Sustainability of Textile Wastewater Management In Textile Sectors -- Chapter 13. Role of Coagulation/ flocculation Technology for the Treatment of Dye Wastewater: Trend and Future Aspect.
    Abstract: Water pollution is a matter of concern for both developing and developed parts of the world. This book presents an overview on water pollution and its sustainable management. The book discusses the fundamental aspects of water pollution as well as advanced sustainable technologies for abating water pollution. It is a comprehensive collection of information related with water pollutants which are extremely harmful to man, other living organisms and to the ecosystems. It is all-inclusive coverage of technical, socio-political, scientific as well as social issues revolving around water pollution and management. The book brings out innovative ideas promoting sustainable technologies and extensively covers the diversity of modern technologies related to prevention of water pollution. Book also covers social aspects of water related issues. It is an essential reading for upper level graduates and undergraduates pursuing environmental studies and researchers in the field of waste water management.
    Type of Medium: Online Resource
    Pages: XVI, 331 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811583582
    URL: https://doi.org/10.1007/978-981-15-8358-2
    DOI: 10.1007/978-981-15-8358-2
    DDC: 363.73
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    Climate Change and Water Resources in Africa : Perspectives and Solutions Towards an Imminent Water Crisis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Sustainability. ; Water. ; Hydrology. ; Climatology. ; Pollution. ; Sustainability. ; Water. ; Climate Sciences.
    Description / Table of Contents: Dedication -- Citations -- Foreword by Felix D. Dakora -- Foreword by Daniel Nyanganyura -- Preface -- Acknowledgement to Peer Reviewers -- Authors and Contributors -- About the Editors -- Chapter 1: Introduction: Water Resource Management within the Climate Change Context in Africa: Synthesis, Key Findings and Future Challenges -- Chapter 2: Africa-wide trends in development and water resources through a climate change lens -- Chapter 3: Water Resource Availability and Quality in the North Africa Region under Climate Change -- Chapter 4: Climate Change and Water Resources in West Africa: A Case Study of Ivory Coast, Benin, Burkina Faso and Senegal -- Chapter 5: Climate change impact on hydrological regimes and extreme events in southern Africa -- Chapter 6: Historic climatic variability and change: the importance of managing Holocene and Late Pleistocene groundwater in the Limpopo River Basin, southern Africa -- Chapter 7: A framework for IWRM in the Water-Energy-Food Nexus for the Senegal River Delta -- Chapter 8: Cumulative Impacts of Climate Change Variability around the Goronyo Dam in the Iullemmeden Basin, Northwest Nigeria -- Chapter 9: Lentic-Lotic Water System Response to Anthropogenic and Climatic Factors in Kenya and their Sustainable Management -- Chapter 10: Hydrology and climate impacts on streamflow and sediment yield in the Nyando River Basin, Kenya -- Chapter 11: Saharan agriculture in the Algerian oasis: limited adaptation to environmental, social and economic changes -- Chapter 12: Water management policy for freshwater security in the context of climate change in Senegal -- Chapter 13: Assessment of Hydrological Impacts of Climate Change on the Diarha Watershed -- Chapter 14: Water resources in the Sahel and adaptation of agriculture to climate change: Burkina Faso -- Chapter 15: Impacts of climate change on water resources in the Volta River Basin: reducing vulnerability and enhancing livelihoods and sustainable development -- Chapter 16: Potential Transboundary Impacts of the Grand Ethiopian Renaissance Dam under Climate Change and Variability -- Chapter 17: Strengthening flood and drought risk management tools for the Lake Chad basin -- Chapter 18: Developing a Framework for the Water-Energy-Food Nexus in South Africa -- Chapter 19:Mainstreaming Climate Change into Transboundary River Basins: a SADC Regional Case Study -- Chapter 20: Does the use of local knowledge in complex systems reduce vulnerability to climate change? Insights from nexus water management in the Niger basin -- Chapter 21: Proposed research, science, technology and innovation to address current and future challenges of climate change and water resource management in Africa -- Index. .
    Abstract: This book dedicated to “Climate Change and Water Resources in Africa” sets out the many challenges and implications of climatic change for freshwater resources in Africa, including its rivers, lakes and aquifers. Under the influence of a range of human factors, the status of water resources in Africa has been changing for decades, transpiring in changes in water flow and variability, falling groundwater levels, changes in rainfall levels and timing, as well as overall decreasing water quality. Indeed, change is not new in this context. Climate change, however, will strongly accelerate the rate of change, affecting the ability of people and societies to respond in a timely manner to address their own needs. With this in mind, this book has been dedicated to providing a deeper analysis of the effects of climate change on water resources in some of the most vulnerable areas in Africa, including the approaches that may help reduce or mitigate the impacts of climate change. In this regard, while there is no quick fix to the pressures imposed on water resources by climate change, it is clear that increasing the resilience of ecosystems and communities to extreme events such as flooding and drought, and integrating climate change risks and opportunities into development decision making, will be key. It is also important that wealthier countries as well as major current GHG-emitting countries assume responsibility for their historic GHG emissions and support those countries that are most impacted by those emissions to adapt to such impacts, while reducing their own carbon footprints. As a whole, this book intends to contribute to the debate around climate change in relation to water resources management in the African continent, and in particular inform policy decisions and actions that will improve governments’ and communities’ ability to manage the challenges of climate change and variability in relation to the aquatic ecosystems upon which they depend.
    Type of Medium: Online Resource
    Pages: XXX, 521 p. 214 illus., 193 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030612252
    URL: https://doi.org/10.1007/978-3-030-61225-2
    DOI: 10.1007/978-3-030-61225-2
    DDC: 363.73
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    Assessing Environmental Risk of Oil Spills with ERA Acute : A New Methodology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environment. ; Environmental monitoring. ; Pollution. ; Water. ; Environmental Sciences. ; Environmental Monitoring.
    Description / Table of Contents: Preface -- Introduction to the concepts and use of Era Acute -- Environmental Risk Management Applications of Era Acute -- An Era Acute Model Overview -- Testing and Validating against Historic Spills -- Handling uncertainty and Sensitivity of Era Acute towards input Parameters -- Supplementary Information 1.
    Abstract: This open access book introduces readers to a new methodology for assessing the risks to the marine environment following accidental oil spills. The methodology will soon be implemented on the Norwegian Continental Shelf and will be complemented by guidelines for its use in a regulatory framework. The brief book is intended to provide international readers with a basic grasp of what the ERA Acute methodology consists of, what its applications are, and the underlying impact and restoration models used in its development. The content is divided into three main parts: an introduction and overview of risk management applications for generalists at the management level, a model overview for generalist scientists, and a more detailed final section for risk assessment professionals, which presents the results of the validation and sensitivity testing. .
    Type of Medium: Online Resource
    Pages: XVI, 119 p. 35 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030701765
    Series Statement: SpringerBriefs in Environmental Science,
    URL: https://doi.org/10.1007/978-3-030-70176-5
    DOI: 10.1007/978-3-030-70176-5
    DDC: 363.73
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    Online Resource
    The Secret Life of Chemicals (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental management. ; Refuse and refuse disposal. ; Environmental health. ; Chemicals Safety measures. ; Pollution. ; Environmental Management. ; Waste Management/Waste Technology. ; Environmental Health. ; Chemical Safety.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2: Pesticides in our food -- Chapter 3. The plastics revolution -- Chapter 4. Toxic metals -- Chapter 5. The Indestructibles -- Chapter 6. Air pollutants -- Chapter 7. Chemicals from paper manufacture and use -- Chapter 8. Chemical exposure in the workplace -- Chapter 9. Fluorocarbons -- Chapter 10: Radiation -- Chapter 11. How do our bodies deal with chemicals? -- Chapter 12: Genetic variability and the risk of disease – the advantages and disadvantages of being different -- Chapter 13. Environmental chemicals and our genes -- Chapter 14. Environmental chemicals and mitochondria -- Chapter 15. Environmental chemicals and our immune system -- Chapter 16: Just because the amounts are small, does it mean they are safe? -- Chapter 17. What can we do for a better future?.
    Abstract: This book provides extensive information on the chemicals that inhabit our environment, our food, our water and our air and the impact that they may be having on human health. The author is a medical scientist, with training in the law. The book documents current understanding about pesticides in food, the plastics revolution, toxic metals, air, water and electronic waste pollutants, chemical exposure in the workplace, radiation pollutants, chemical exposure and hearing loss, how our bodies deal with chemicals, genetic variability and the risk of disease, the effect of chemicals on genes, mitochondria and the immune system and what we can do about it all. Industrialisation has resulted in many thousands of chemicals, which are being continuously developed and often escaping from where they are used into our human environment, without us really knowing enough about them. In high dosages or with continuous small dosage, the evidence suggests, that many of them could interfere with human health and some of them are known to be doing so. But for the vast majority, we are left wondering whether some could be responsible for some diseases the causes of which are inadequately understood. Every chapter is thoroughly reinforced with several pages of references from the peer-reviewed literature.
    Type of Medium: Online Resource
    Pages: XV, 241 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030803384
    URL: https://doi.org/10.1007/978-3-030-80338-4
    DOI: 10.1007/978-3-030-80338-4
    DDC: 363.73
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    Microplastic Pollution (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Environmental management. ; Sustainability. ; Pollution. ; Environmental Management. ; Sustainability.
    Description / Table of Contents: Effect Of Textile Parameters On Microfiber Shedding Properties Of Textiles -- Current State Of Microplastics Research In Saarc Countries – A Review -- Distribution And Impact Of Microplastics In The Aquatic Systems: A Review Of Ecotoxicological Effects On Biota -- Microplastics Pollution In Marine Environment: Occurrence, Fate And Effects (With A Specific Focus On Biogeochemical Carbon And Nitrogen Cycles -- Domestic Laundry And Microfiber Shedding Of Synthetic Textiles -- Microplastics In Dentistry- A Review.
    Abstract: This book addresses the emergent need to act on reducing or getting rid of micro plastic pollution, to achieve a sustainable environment. Microplastics are small plastic pieces, which are less than five millimeters long which can be harmful to our oceans and aquatic life. These predominantly include microfibers from clothing, microbeads, and plastic pellets. Microplastics impact aquatic creatures, turtles and birds. According to the first study on estimation of human ingestion of microplastic, on average a person consumes at least 50,000 particles of microplastic a year and breathes a similar quantity. Ingested microplastic particles can physically damage organs and also compromise immune function and stymie growth and reproduction. This book presents six informative chapters in order to alleviate the above mentioned issues .
    Type of Medium: Online Resource
    Pages: IX, 174 p. 28 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602979
    Series Statement: Sustainable Textiles: Production, Processing, Manufacturing & Chemistry,
    URL: https://doi.org/10.1007/978-981-16-0297-9
    DOI: 10.1007/978-981-16-0297-9
    DDC: 363.73
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    Management of Irrigation and Water Supply Under Climatic Extremes : Empirical Analysis and Policy Lessons from India (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environment. ; Climatology. ; Environmental management. ; Natural disasters. ; Pollution. ; Water. ; Environmental Sciences. ; Climate Sciences. ; Environmental Management. ; Natural Hazards.
    Description / Table of Contents: Chapter 1. Climate Risks for Irrigation, Water Supply and Sanitation in India: Overview and Synthesis -- Chapter 2. Climate Variability and Its Implications for Water Management in India -- Chapter 3. Water Management Challenges of Climate Extremes: A Case Study of Adaptive Strategies and Management Options -- Chapter 4. Managing Climate-Induced Water Risks: A Case Study of Institutional Alternatives -- Chapter 5. Planning for Water Resources Management under Climatic Extremes: The Case Study of a Hyper-arid Region -- Chapter 6. Planning of Rural Water Supply Systems: Role of Climatic Factors and Other Considerations -- Chapter 7. A Framework for Assessing Climate-induced Risk for Water Supply, Sanitation and Hygiene -- Chapter 8. Mapping Climate-Induced Risk for Water Supply, Sanitation and Hygiene in Maharashtra -- Chapter 9. Predictions of Disease Spikes induced by Climate Variability: A Pilot Real Time Forecasting Model Project from Maharashtra, India -- Chapter 10. Mapping Climate-Induced Risk for Water Supply, Sanitation and Hygiene in Rajasthan -- Chapter 11. Action Plans for Building Climate-Resilient Water Supply and Sanitation Systems: Results from Case Studies -- Chapter 12. Managing Climate-Induced Water Stress across the Agro-ecological Regions of India: Options and Strategies. Chapter 13. Conclusions and Areas for Future Research.
    Abstract: This volume provides a theoretical basis for the argument that available research that analyzes the impacts of climate on hydrology, water resources, and water systems, without factoring in the effect of climate variability, are inadequate and often misleading. Also, the book empirically shows that the impacts of climate variability on hydrology and water resources, and irrigation, water supply & sanitation systems are far more pronounced than the likely impacts of future change in climate. The book discusses technological, institutional and policy alternatives for reducing these impacts on various competitive use sectors, especially, irrigation, and water supply and sanitation through case studies of river basins in different hydrological setting. To set the context, the volume first presents the long term trends in precipitation and temperature in different regions of India, and compares them against inter-annual, inter-seasonal and intra-day variations in climatic parameters, to show how their differential impacts on water resources.
    Type of Medium: Online Resource
    Pages: XXV, 371 p. 99 illus., 80 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030594596
    Series Statement: Global Issues in Water Policy, 25
    URL: https://doi.org/10.1007/978-3-030-59459-6
    DOI: 10.1007/978-3-030-59459-6
    DDC: 363.73
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    Atlas of Fallen Dust in Kuwait (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental geography. ; Atmospheric science. ; Analytical chemistry. ; Climatology. ; Pollution. ; Integrated Geography. ; Atmospheric Science. ; Analytical Chemistry. ; Climate Sciences.
    Description / Table of Contents: Dust storm Satellite images -- Deposited dust -- Dust particles size and statistical parameters -- Mineralogy (XRD) -- Inductively coupled plasma(ICP) -- Deposited rates of radionuclides -- Pollen in dust -- Other properties -- Spectro absorption.
    Abstract: This open access book serves as an atlas of deposited dust and dust storms in Kuwait in relation to local and global regions. It features a wealth of maps and images of dust storm trajectories in the region, together with detailed descriptions of the chemical and physical properties of fallen dust, including the amount, particle size, statistical parameters, spectra absorption, dust mineralogy, trace and major elements, organic matter, associated pollen, and radionuclides and connected pollutants. Given its scope, the book is a valuable resource for a broad range of researchers, including geologists, chemists, environmentalists, botanists, air quality specialists, nanotechnology scientists, and solar energy experts.
    Type of Medium: Online Resource
    Pages: XI, 250 p. 272 illus., 267 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669775
    URL: https://doi.org/10.1007/978-3-030-66977-5
    DOI: 10.1007/978-3-030-66977-5
    DDC: 363.73
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    Water Governance and Management in India : Issues and Perspectives, Volume 2 (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Sustainability. ; Climatology. ; Environmental management. ; Pollution. ; Water. ; Sustainability. ; Climate Sciences. ; Environmental Management.
    Description / Table of Contents: Introduction -- Catalysing groundwater governance -- Sustainable urban water management strategies -- Estimating efficiency of public investments in irrigation -- Tackling water quality issues -- Wetlands and water management: Finding common ground -- Data usage for development, management of water resources -- Whither federal governance for India’s long-term water security?
    Abstract: This book, the second volume in the series, continues to raise contextual issues and presents perspectives regarding multifaceted challenges in management and governance of water in India. This volume attempts to broad base and expand the dialogue started in the first volume and would touch upon issues that need immediate discussion but have been left unattended like politics and management of groundwater, efficient utilization of water in agriculture (irrigation) and improving water use efficiency and building resilience. As in the first volume, this book presents a set of suggestions and recommendations in each chapter that can help frame policy guidelines in the country.
    Type of Medium: Online Resource
    Pages: XIII, 188 p. 29 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811614729
    Series Statement: Water Resources Development and Management,
    URL: https://doi.org/10.1007/978-981-16-1472-9
    DOI: 10.1007/978-981-16-1472-9
    DDC: 363.73
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    Pollution Control Technologies : Current Status and Future Prospects (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Environmental health. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Pollution. ; Environmental Health. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Pollution Control Technologies: Current Status and Future Prospect -- Remediation of Persistent Organic Pesticides from Wastewater Matrices‒ Present and Future Conceptions -- Uranium(VI) ions Removal from the Aqueous Environment: Current Treatment Technologies and its Future Prospects -- A Study on Different Bioremediation Approaches to Hexavalent Chromium -- Dissolved Arsenic in Groundwater Bodies: A Short Review of Remediation Technologies -- Occurrence, Fate and Removal of Microplastics in Sewage Treatment Plants (STPs) -- Membrane Technology for Desalination and Wastewater recycling -- Forward Osmosis in Desalination and Wastewater Treatment -- Food Processing Wastewater Treatment: Current Practices and Future Challenges -- Energy Analysis of Wastewater Infrastructure -- Prediction of Hospital visits for Respiratory Morbidity due to Air Pollutants in Lucknow -- Technologies for Controlling Particulate Matter Emissions from Industries.
    Abstract: This monograph is based on pollution control technologies available to deal with water and air pollution. It includes removal of variety of pollutants including arsenic, chromium, uranium, pesticides and arsenic from water using adsorption technique. In addition, this book deals with the sampling and removal of microplastics using various techniques. The contents also focus on the role of membrane technology in water and wastewater treatment, and particulate matter air pollution and its control techniques. This volume will be a useful guide for researchers, academics and scientists.
    Type of Medium: Online Resource
    Pages: XV, 290 p. 76 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811608582
    Series Statement: Energy, Environment, and Sustainability,
    URL: https://doi.org/10.1007/978-981-16-0858-2
    DOI: 10.1007/978-981-16-0858-2
    DDC: 363.73
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    Histone Mutations and Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
    Abstract: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
    Type of Medium: Online Resource
    Pages: VII, 96 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581045
    Series Statement: Advances in Experimental Medicine and Biology, 1283
    URL: https://doi.org/10.1007/978-981-15-8104-5
    DOI: 10.1007/978-981-15-8104-5
    DDC: 571.978
    Language: English
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    Role of Exosomes in Biological Communication Systems (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
    Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 373 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811565991
    URL: https://doi.org/10.1007/978-981-15-6599-1
    DOI: 10.1007/978-981-15-6599-1
    DDC: 571.978
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    Cancer Metabolomics : Methods and Applications (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    URL: https://doi.org/10.1007/978-3-030-51652-9
    DOI: 10.1007/978-3-030-51652-9
    DDC: 571.978
    Language: English
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    Resistance to Targeted Therapies in Multiple Myeloma (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    URL: https://doi.org/10.1007/978-3-030-73440-4
    DOI: 10.1007/978-3-030-73440-4
    DDC: 571.978
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    Notch Signaling in Embryology and Cancer : Notch Signaling in Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    URL: https://doi.org/10.1007/978-3-030-55031-8
    DOI: 10.1007/978-3-030-55031-8
    DDC: 571.978
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    Emerging Trends in Nanomedicine (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    URL: https://doi.org/10.1007/978-981-15-9920-0
    DOI: 10.1007/978-981-15-9920-0
    DDC: 571.978
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    Biomarkers and Biosensors for Cervical Cancer Diagnosis (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumor markers. ; Medical screening. ; Materials. ; Detectors. ; Cancer Biology. ; Tumour Biomarkers. ; Cancer Screening. ; Sensors and biosensors.
    Description / Table of Contents: Chapter 1. An Introduction to Cancer Biomarkers -- Chapter 2. Cervical Cancer -- Chapter 3. Potential Biomarkers for Early Diagnosis of Cervical Cancer -- Chapter 4. Methods for Screening of Cervical Cancer: State of Art -- Chapter 5. Electrochemical DNA Biosensors for Cervical Cancers -- Chapter 6. Optical DNA based Sensors for Cervical Cancers -- Chapter 7. Other Biosensors for Cervical Cancer Detection.
    Abstract: This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.
    Type of Medium: Online Resource
    Pages: IX, 115 p. 18 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811625862
    URL: https://doi.org/10.1007/978-981-16-2586-2
    DOI: 10.1007/978-981-16-2586-2
    DDC: 571.978
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    Tumor Microenvironment : Novel Concepts (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    URL: https://doi.org/10.1007/978-3-030-73119-9
    DOI: 10.1007/978-3-030-73119-9
    DDC: 571.978
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    Tumor Microenvironment : The Role of Chemokines – Part B (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Proteins . ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Protein Biochemistry. ; Internal Medicine.
    Description / Table of Contents: CCL2 in the tumor microenvironment -- CXCL3 signaling in the tumor microenvironment -- CXCL8 Signaling in the Tumor Microenvironment -- CXCL11 signaling in the tumor microenvironment -- CXCL12 signaling in the tumor microenvironment -- CXCL13 signaling in the tumor microenvironment -- CCL24 signaling in the tumor microenvironment -- CCL25 signaling in the tumor microenvironment -- CCL27 signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: IX, 139 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626587
    Series Statement: Advances in Experimental Medicine and Biology, 1302
    URL: https://doi.org/10.1007/978-3-030-62658-7
    DOI: 10.1007/978-3-030-62658-7
    DDC: 571.978
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    The Future of Prevention and Treatment of Breast Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    URL: https://doi.org/10.1007/978-3-030-72815-1
    DOI: 10.1007/978-3-030-72815-1
    DDC: 571.978
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    Translational Research in Breast Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Cancer Biology. ; Biomedical Research. ; Medical Biochemistry.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist -- Part II. Breast Cancer Biology and Cell Signaling Pathways -- Chapter 2. Phospholipase Signaling in Breast Cancer -- Chapter 3. HER2 Signaling in Breast Cancer -- Chapter 4. Ras Signaling in Breast Cancer -- Chapter 5. Epigenetic Regulation in Breast Cancer -- Chapter 6. Role of tRNAs in Breast Cancer Regulation -- Chapter 7. Fusion Genes in Breast Cancer -- Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment -- Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer -- Chapter 9. Breast Cancer Metastasis -- Chapter 10. Single Cell Genomics for Tumor Heterogeneity -- Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics -- Chapter 12. Cancer Stem Cell in Immune Microenvironment -- Chapter 13. Theranostics for Breast Cancer Stem Cells -- Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research -- Part IV Biomarkers for Precision Medicine in Breast Cancer Patients -- Chapter 15. Proteomic Interrogation in Cancer Biomarker -- Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer -- Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA -- Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer -- Chapter 19. The Potential Predictors in Chemotherapy Sensitivity -- Chapter 20. Hormone Resistance -- Part V. Managing High Risk Women -- Chapter 21. High-Risk Population Based on BC Risk Factors -- Chapter 22. Breast Cancer-Related Low Penetrance Genes -- Chapter 23. Rare Coding Variants Associated with Breast Cancer -- Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling -- Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes -- Part VI. Next Generation Clinical Research -- Chapter 26. Clinical Databases for Breast Cancer Research -- Chapter 27. Care for Breast Cancer Survivors -- Chapter 28. Considerations in Oncoplastic Surgery -- Chapter 29. Diet Before and After Breast Cancer -- Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer -- Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes -- Chapter 32. Malignant Phyllodes of Breast -- Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations -- Part VII. Epilogue -- Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.
    Abstract: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
    Type of Medium: Online Resource
    Pages: IX, 630 p. 122 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813296206
    Series Statement: Advances in Experimental Medicine and Biology, 1187
    URL: https://doi.org/10.1007/978-981-32-9620-6
    DOI: 10.1007/978-981-32-9620-6
    DDC: 571.978
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    The Heterogeneity of Cancer Metabolism (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Cancer Metabolism. ; Cancer Therapy. ; Cancer Biology.
    Description / Table of Contents: Part I. Basic Metabolism of Cancer Cells -- Glucose Metabolism in Cancer the Warburg effect and Beyond -- Glutamine Metabolism in Cancer -- The Heterogeneity of Lipid Metabolism in Cancer -- Part II. Heterogeneity of Cancer Metabolism -- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions -- The Intricate Metabolism of Pancreatic Cancers -- The heterogeneity of breast cancer metabolism for therapy -- Non-Hodgkin Lymphoma Metabolism -- The Heterogeneity Metabolism of Renal Cell Carcinomas -- The Heterogeneity Metabolism of Liver Cancer -- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes -- The Intratumoral Heterogeneity of Cancer Metabolism -- Cancer Stem Cells Metabolism -- Metabolism of Immune cells in the Tumor Microenvironment -- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts -- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells -- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts -- Part IV. The metabolic interplay between cancer and other diseases -- Diabetes and Cancer: the Epidemiological and Metabolic Associations -- Bridging the Metabolic Parallels between Neurological Diseases and Cancer -- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy -- Index.
    Abstract: This open access volume will introduce recent discoveries in the field of cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, etc. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. .
    Type of Medium: Online Resource
    Pages: XXIII, 271 p. 55 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030657680
    Series Statement: Advances in Experimental Medicine and Biology, 1311
    URL: https://doi.org/10.1007/978-3-030-65768-0
    DOI: 10.1007/978-3-030-65768-0
    DDC: 571.978
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    Tumor Microenvironment : The Role of Interleukins – Part B (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Tumors Immunological aspects. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Interleukin-6 function and targeting in prostate cancer -- IL-7 signaling in the tumor microenvironment -- IL-10 Signaling in the Tumor Microenvironment of Epithelial Ovarian Cancer -- Targeted delivery of IL-12 adjuvants immunotherapy by oncolytic viruses -- IL-22 signaling in the tumor microenvironment -- IL-23 and the Tumor Microenvironment -- Interleukin (IL)-24: Reconfiguring the tumor microenvironment for eliciting antitumor response -- Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XII, 134 p. 23 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030556174
    Series Statement: Advances in Experimental Medicine and Biology, 1290
    URL: https://doi.org/10.1007/978-3-030-55617-4
    DOI: 10.1007/978-3-030-55617-4
    DDC: 571.978
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    Polyphenols-based Nanotherapeutics for Cancer Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Nanomedicine. ; Immunology. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology. ; Immunology. ; Cancer Stem Cells.
    Description / Table of Contents: Chapter 1_Introduction and classification of natural polyphenols -- Chapter 2_Polyphenol intakes and risk of cancer: An epidemiological scenario -- Chapter 3_Polyphenols-based prevention and therapeutics in different cancers -- Chapter 4_Effect of polyphenols on signaling pathways -- Chapter 5_Role of polyphenols in modulating gene expression in different cancers -- Chapter 6_Effect of polyphenols on Inflammation and immune response in cancer -- Chapter 7_Epigenetic basis of polyphenols in cancer prevention and therapy -- Chapter 8_Polyphenols and cancer stem cells (CSCs) -- Chapter 9_Polyphenols as modulator of oxidative stress in cancer disease -- Chapter 10_Development of novel therapeutics for enhanced polyphenol delivery -- Chapter 11_Toxicological concern of different bioactive polyphenols as anticancer agents.
    Abstract: This book reviews the applications of polyphenols in cancer treatment. The initial chapter of the book classifies different polyphenols and discusses their biological and chemical properties. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. This book highlights the usefulness of polyphenol enriched seafood in modulating the anti-tumor and anti-inflammatory cytokine IFN-γ. The book also presents nanoformulation of polyphenol as a promising strategy for their enhanced bioavailability and targeted delivery. Lastly, the book examines the toxicity and safety evaluations of polyphenols as anticancer agents.
    Type of Medium: Online Resource
    Pages: XIII, 437 p. 85 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811649356
    URL: https://doi.org/10.1007/978-981-16-4935-6
    DOI: 10.1007/978-981-16-4935-6
    DDC: 571.978
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    Handbook of Water Resources Management: Discourses, Concepts and Examples (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Physical geography. ; Public health. ; Engineering geology. ; Pollution. ; Water. ; Earth System Sciences. ; Public Health. ; Geoengineering.
    Description / Table of Contents: Introduction and Guide to the Handbook of Water Resources Management: Discourses, Concepts and Examples -- Water a unique phenomenon and resource -- Water and its Management: Dependence, Linkages and Challenges -- A drop in the ocean: on writing histories of water resource management -- Water Ethics -- Water law and rights -- Water discourses -- The water security discourse and its main actors -- Water governance and policies -- Economics of water security -- Drivers, pressures and stressors: the societal framework of water resources management -- Water resources management: integrated and adaptive decision making -- Observation, monitoring and data management -- Assessment of water quantity -- Assessment of land/catchment use and degradation -- Freshwaters: global distribution, biodiversity and ecosystem services, and human pressures -- Water, energy and food relations in Gulf Cooperation Council -- Examples of water resources management options -- Examples of water and land use management -- Water and energy -- Water management and stewardship in mining regions -- Water-related hazard and risk management -- Groundwater and conjunctive use management -- Storage Reservoir Operation and Management -- Complexity in water management and governance.
    Abstract: This book provides an overview of facts, theories and methods from hydrology, geology, geophysics, law, ethics, economics, ecology, engineering, sociology, diplomacy and many other disciplines with relevance for concepts and practice of water resources management. It provides comprehensive, but also critical reading material for all communities involved in the ongoing water discourses and debates. The book refers to case studies in the form of boxes, sections, or as entire chapters. They illustrate success stories, but also lessons to be remembered, to avoid repeating the same mistakes. Based on consolidated state-of-the-art knowledge, it has been conceived and written to attract a multidisciplinary audience. The aim of this handbook is to facilitate understanding between the participants of the international water discourse and multi-level decision making processes. Knowing more about water, but also about concepts, methods and aspirations of different professional, disciplinary communities and stakeholders professionalizes the debate and enhances the decision making.
    Type of Medium: Online Resource
    Pages: XXX, 810 p. 323 illus., 269 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030601478
    URL: https://doi.org/10.1007/978-3-030-60147-8
    DOI: 10.1007/978-3-030-60147-8
    DDC: 363.73
    Language: English
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  • 90
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    Strategies and Tools for Pollutant Mitigation : Avenues to a Cleaner Environment (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental chemistry. ; Agriculture. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Chemistry. ; Agriculture.
    Description / Table of Contents: Part I- Reviews on energy and environment -- Chapter 1. A review on production, properties and applications microbial surfactants as a promising biomolecule for environmental applications (Kidist Mulugeta, M. Kamaraj, Mesfin Tafesse & J. Aravind) -- Chapter 2. Hairy Root Applications in Phytoremediation – An updated Review (Anil Kumar Moola, Balasubramanian P, Lakkakula Satish, Sasanala Shamili, Manikandan Ramesh, T. Senthil Kumar & B. D. Ranjitha Kumari) -- Chapter 3. Pretreatment of wheat straw using ionic liquids for bioethanol production – A review (Ibsa Neme & Chandra Masi) -- Chapter 4. Harnessing the sustainable bioresource, cellulose at the nanoscale for multifarious environmental applications (Ebrahim M. Abda & Rocktotpal Konwarh) -- Chapter 5. Allelochemicals as natural herbicides for sustainable agriculture to promote a cleaner environment- A review (Hemalatha Palanivel, Gebiyaw Tilaye, Sathish Kumar Belliathan, Solomon Benor, Solomon Abera & Kamaraj M) -- Chapter 6. Strategies and limitations of water treatment methods for point-of-use application (N. R. Srinivasan, M. Kamaraj & S. Venkatesa Prabhu) -- Part II - Cleaner technologies on mitigation of organic and inorganic pollutants -- Chapter 7. Recent trends in application of Bacterial polymers to mitigate organic and inorganic pollutants (P Muthukumaran, J Aravind, M Kamaraj & KK Ramachandran) -- Chapter 8. Bioremediation: Efficient technology to combat Pesticide pollutants in Environment (Raman Kumar Ravi & R.Y. Hiranmai) -- Chapter 9. Removal of dyes from industrial effluents using bioremediation technique (Narayana Saibaba K.V.) -- Chapter 10. A harmless approach on textile effluent detoxification: bioremediation and its recent strategies (R. Kavitha, S. Venkatesa Prabhu & Melkamu Kifetew. M) -- Chapter 11. Modern Bioremediation Approaches for Clean and Green Environment (AnkitaMurmu, S. Murugan) -- Chapter 12. Arsenic-transforming bacteria – A potential weapon for Arsenic contaminated soil (Radhesh Krishnan Subramanian & Prabhakaran Narayanasamy) -- Chapter 13. Phycoremediation of heavy metals, factors involved and mechanisms related to functional groups in the algae cell surface- A review (Abate Ayele, Arumuganainar Suresh & Solomon Benor) -- Chapter 14. Heavy Metal Extraction from E-Waste through Bioleaching: A Promising Ecofriendly Approach (S. Venkatesa Prabhu, N.R. Srinivasan & Sintayehu Mekuria. H.) -- Chapter 15. Potential of Free Floating Macrophytes for Bioremediation of Heavy Metals – A conceptual Review (Punita Parikh & Krupa Unadkat) -- Chapter 16. Bioremediation of heavy metals using Salvinia molesta – a freshwater aquatic weed for pollutant remediation approach (Nithya T.G, Snegapriya P & Kamaraj M) -- Chapter 17. Mycoremediation: Fungal-based technology for biosorption of heavy metals – A Review (Abate Ayele, Setegn Haile, Digafe Alemu, Tamiru Tesfay & Kamaraj Murugesan) -- Part III - Impact and risk assessments -- Chapter 18. Geospatial modelling of air pollution and its impact on the health of urban residents using spatial statistical models - A review (Janani Selvaraj, Harathi Dayalan & Prashanthi Devi M) -- Chapter 19. Health impacts of contaminated water in India: Coping Strategies for Sustainable Development (J.V. Arun & A. Premkumar) -- Chapter 20. The potential of biotechnology on soil quality by minimizing agrochemical impact to ensure sustainable agriculture - A review (Solomon Abera).
    Abstract: This volume explores recent research trends and achievements in environmental pollution remediation (e.g. water, air, soil), and compiles critical and constructive papers and reviews with a focus on advances in bioremediation and green technology solutions for waste minimization, waste management and pollution control. The book is timely, as the need for researchers and engineers to develop sustainable and green eco-friendly remediation technologies is increasing with a growing global population, stressed agricultural systems, and an environment impacted by climate change. A key focus of the book is on the efficient use of agricultural waste residues as viable substrates for creating materials for environmental clean-up, and the possible conversion of these pollutants to sustainable bioresources. The volume will be of interest to sustainability researchers, environmental engineers, industry managers and agricultural scientists. .
    Type of Medium: Online Resource
    Pages: VII, 450 p. 92 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030635756
    URL: https://doi.org/10.1007/978-3-030-63575-6
    DOI: 10.1007/978-3-030-63575-6
    DDC: 363.73
    Language: English
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  • 91
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    Quality of Water Resources in Poland (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environmental management. ; Pollution. ; Water. ; Environmental Management.
    Description / Table of Contents: Assessment Of Water Resources In Poland -- Development and Protection of Water Resources in Protected Areas in Poland in Pursuit of Sustainable Developmen.– Anthropogenic Water Reservoirs in Poland -- Irrigation and Drainage in Polish Agriculture – State, Problems and Needs -- Assessment of the Surface Water Quality in Poland -- Water Quality in Main Water Reservoirs in Poland -- Assessment of Pollution of Water Resources and Process of Pollution Spreading -- ngression and Ascension of Saline Waters on the Polish Coast of the Baltic Sea -- Monitoring of Groundwater Quality in Poland -- Sediment Management in River Basins - an Essential Element of River Basin Management Plans -- Environmental and Anthropogenic Determinants of Water Chemistry in the Carpathians -- Surface Water Eutrophication in Poland: Assessment and Prevention -- Monitoring of Small Catchments in Poland as Part of the Integrated -- Water and Wastewater Management Condition in Poland -- Water Problems in Urban Areas -- Multidimensional Aspect of the Water Resources Management in Metropolitan Areas -- Conclusions and Recommendations.
    Abstract: This book presents state-of-the-art knowledge concerning water quality in Poland. It offers a wide variety of cases and issues on water resource quality management. The book also presents different methods and strategies to effectively use the most advanced water resource quality problems such as water pollution, whether physical, chemical, or biological, of surface water resources and groundwater resources. The authors pay exceptional attention to water quality monitoring in agricultural, urban catchments, and water reservoirs. More light into the water quality is required to assess water's physicochemical status accurately and plan suitable protection actions against recognized threats. This book addresses the needs of professional engineers, researchers, policy planners, decision-makers, stakeholders, and anyone looking to learn more about the quality situation of water resources in Poland and other similar countries and regions.
    Type of Medium: Online Resource
    Pages: XII, 464 p. 174 illus., 155 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030648923
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-3-030-64892-3
    DOI: 10.1007/978-3-030-64892-3
    DDC: 363.73
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  • 92
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    Bioenergy Research: Revisiting Latest Development (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Refuse and refuse disposal. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental chemistry. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Engineering/Biotechnology. ; Environmental Chemistry.
    Description / Table of Contents: 1 Biofuel Production Technologies, Comparing the Biofuels and Fossil Fuels -- 2 Microbiological aspects of bioenergy production: Recent update and future directions -- 3 A Comprehensive Review on Microbial Technology for Biogas Production -- 4 Biohydrogen Production from Biomass -- 5 Recent updates of biodiesel production: Source, production methods and metagenomic approach -- 6 Process Modelling and Simulation of Biodiesel Synthesis Reaction for Non-edible Yellow -- 7 Microbial Xylanases: A Helping Module for the Enzyme Biorefinery Platform -- 8 Analysis of various green methods to synthesize nanomaterials: An Ecofriendly Approach. .
    Abstract: This volume is second part of the five-part set on bioenergy research. This book provides new insight about the latest development in bioenergy research. It presents the various bioenergy options which are further explored for practical viability, their progress and utility in the industry. The main objective of the book is to provide insights into the opportunities and required actions for the development of an economically viable bioenergy industry for practical replacement of fossil fuels. This book is of interest to teachers, researchers, scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of environmental sciences. National and international bioenergy scientists, policy makers will also find this to be a useful read. Other four volumes of this set explore basic concepts, commercial opportunities, waste to energy and integrated solution for bioenergy concerns.
    Type of Medium: Online Resource
    Pages: XII, 205 p. 62 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813346154
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-33-4615-4
    DOI: 10.1007/978-981-33-4615-4
    DDC: 363.73
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    ICT for Smart Water Systems: Measurements and Data Science (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Geographic information systems. ; Big data. ; Application software. ; Measurement. ; Measuring instruments. ; Pollution. ; Geographical Information System. ; Big Data. ; Computer and Information Systems Applications. ; Measurement Science and Instrumentation.
    Description / Table of Contents: Data science trends and opportunities for smart water utilities -- Review of Techniques for Optimal Placement of Pressure and Flow Sensors for Leak/Burst Detection and Localisation in Water Distribution Systems -- A bird’s-eye view of data validation in the drinking water industry of The Netherlands.-Monitoring and controlling a smarter wastewater treatment system: a UK perspective -- Using Radial Basis Function for Water Quality Events Classification -- Promoting Smart Water Systems in Developing Countries through Innovation Partnerships: Evidence from VIA Water-supported projects in Africa -- Exploring assimilation of Crowdsourcing Observations into Flood Models -- Precipitation measurement with weather radar -- Satellite Remote Sensing of Soil Moisture for Hydrological Applications: A Review of Issues to Be Solved -- Spectroscopic Methods for Online Water Quality Monitoring -- Quartz-Crystal Microbalance sensors: new tools for the assessment of organic threats to the quality of water.
    Abstract: Today, Information and Communication Technologies (ICT) have a pervasive presence in almost every aspect of the management of water. There is no question that the collection of big data from sensing and the insights gained by smart analytics can bring massive benefits. This book focuses on new perspectives for the monitoring, assessment and control of water systems, based on tools and concepts originating from the ICT sector. It presents a portrait of up-to-date sensing techniques for water, and introduces concepts and implications with the analysis of the acquired data. Particular attention is given to the advancements in developing novel devices and data processing approaches. The chapters guide the reader through multiple disciplinary contexts, without aiming to be exhaustive, but with the effort to present relevant topics in such a highly multi-disciplinary framework. This book will be of interest to advanced students, researchers and stakeholders at various levels.
    Type of Medium: Online Resource
    Pages: XX, 342 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030619732
    Series Statement: The Handbook of Environmental Chemistry, 102
    URL: https://doi.org/10.1007/978-3-030-61973-2
    DOI: 10.1007/978-3-030-61973-2
    DDC: 363.73
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  • 94
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    Anthropogenic Pollution of Aquatic Ecosystems (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Environment. ; Biology. ; Pollution. ; Ecosystems. ; Freshwater and Marine Ecology. ; Environmental Sciences. ; Biological Sciences.
    Description / Table of Contents: 1. Introduction -- 2. Pollution affecting cyanobacteria in aquatic habitats -- 3. Effects of pollution on fish -- 4. Effects of pollution in aquatic food chains -- 5. Pollution in the Arctic Ocean -- 6. Contamination of coral reefs in the Mexican Caribbean.
    Abstract: This book provides examples of pollutants, such as accidental oil spills and non-degradable plastic debris, which affect marine organisms of all taxa. Terrestrial runoff washes large amounts of dissolved organic materials from agriculture and industry, toxic heavy metals, pharmaceuticals, and persistent organic pollutants which end up into rivers, coastal habitats, and open waters. While this book is not intended to encyclopaedically list all kinds of pollution, it rather exemplifies the problems by concentrating on a number of serious and prominent recent developments. The chapters in this book also discuss measures to decrease and remove aquatic pollution to mitigate the stress on aquatic organisms. Aquatic ecosystems provide a wide range of ecological and economical services. In addition to providing a large share of the staple diet for a fast growing human population, oceans absorb most of the anthropogenically emitted carbon dioxide and mitigate climate change. As well as rising temperatures and ocean acidification, pollution poses increasing problems for aquatic ecosystems and organisms reducing its functioning and services which are exposed to a plethora of stress factors.
    Type of Medium: Online Resource
    Pages: XIII, 426 p. 71 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756024
    URL: https://doi.org/10.1007/978-3-030-75602-4
    DOI: 10.1007/978-3-030-75602-4
    DDC: 363.73
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    Nanotoxicology and Nanoecotoxicology Vol. 2 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Nanomedicine. ; Pollution. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Chapter 01 Nanosensors applications in food, medicine, agriculture and nanotoxicology -- Chapter 02 Nanosensors for the detection of chemical food adulterants -- Chapter03 Metal oxides and biopolymer/metal oxides bionanocomposites as green nanomaterials for heavy metals removal -- Chapter 04 Impact of nanomaterials on the food chain -- Chapter 05 Phytotoxic impact of nanomaterials for nanosafety -- Chapter 06 Review of Bioaccumulation, biomagnification, and biotransformation of nanomaterials -- Chapter 07 Nanomaterials and human health: An overview -- Chapter 08 Nanomaterials and human health: Nano-biomaterials in dentistry -- Chapter 09 Nanotoxicological approaches towards nanosafety -- Chapter 10 Nanomaterials in the treatment and prevention of human oral infections -- Chapter 11 Nanomaterials causing cellular toxicity and genotoxicity -- Chapter 12 Techniques, methods, procedures and protocols in nanotoxicology -- Index.
    Abstract: This book reviews advances in the toxicity of nanomaterials, with focus on nanosensors and nanotoxicity testing, biomagnification, biotransformation, nanosafety, genotoxicity, human health and remediation. This is the second volume on Nanotoxicology and Nanoecotoxicology published in the book series Environmental Chemistry for a Sustainable World.
    Type of Medium: Online Resource
    Pages: XII, 305 p. 73 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030694920
    Series Statement: Environmental Chemistry for a Sustainable World, 67
    URL: https://doi.org/10.1007/978-3-030-69492-0
    DOI: 10.1007/978-3-030-69492-0
    DDC: 363.73
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    Advances in Environment Engineering and Management : Proceedings of the 1st National Conference on Sustainable Management of Environment and Natural Resource Through Innovation in Science and Technology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pollution. ; Environmental management. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Pollution. ; Environmental Management. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Water Quality Assessment of Streams of Doon Valley, Dehradun, Uttarakhand -- Synthesis and Medicinal Importance of Benzoxazine, Benzoxazinone and their Derivatives: A short review -- A review on Onshore drilling for Oil and Gas Production with its safety barrier and well control method -- Cultivation Effectiveness and Efficiency using 5S methodology -- COVID19: Impact on environmental parameters during the lockdown period in India -- Impact of Lockdown due to COVID 19 Pandemic on Air Quality of Global Environment -- Stress condition modeling to optimize mud weight window for efficient drilling -- COVID-19 Fallout: India, Power Sector and Lockdown -- Assessing the Impact of Novel Coronavirus (COVID-19) on Renewable Energy Sector of India during the lockdown -- Study of the ecological effect of bismuth layered structured ferroelectric materials over lead zirconate titanate -- Convalescent the ecosystem by enhancing the life cycle of lubricants with blended Nano oxides -- Traditional and Modern Agriculture Implements Used in Agro Sciences - A Case Study in the Part of National Capital Region of Uttar Pradesh, India -- Synthesis, Characterization and Evaluation of Iron-molybdenum Oxide Catalyst for the Hydrothermal Liquefaction of Wastewater to Bio-oil -- Synthesis characterization and Biological Aspects of Novel Indole Derivatives -- A Review of Challenges and Safety Measures in Petroleum Industry duringCOVID-19 -- Sustainable City Planning Strategy Review for Next-Level Technology, Earthquake-Resistant Buildings, Dehradun City -- Investigation of Energy Generation on Large Rotary Wing Unmanned Aerial Vehicle’s Propeller using Coupled Engineering Approaches -- Beneficiation Study of Barsuan Iron Ore Slime to Produce Pellet Grade Concentrate -- Effect of Different Temperature on Host Susceptibility to SMV- Mild and SMV-Severe Isolates of Soybean(Glycine max) -- Development of a conceptual safety culture framework to enhance workplace safety -- Implementation of Total Quality Management in Construction Industry -- Study on Effective Management of Total Suspended Particulate Matter Generated at a High-Rise Building Construction Site -- Women empowerment and Sustainable development in Uttarakhand: challenges and strategies – A case study of selected villages of Dehradun City -- Varietal reaction on the Cultivators of Cucurbita Pepo against two different isolates of Pumpkin Mosaic Virus -- A new method for estimation of staircase evacuation time in high rise buildings -- Study of Carbon Emission during taxi-out operation at International Airport, India -- Healthcare Sustainability through Technological Innovations -- An envelopment analysis by benchmarking the criteria of GRIHA in performance assessment of green building -- Dependence of Physiochemical Features on Marine Chlorophyll Analysis with Learning Techniques -- COVID-19 Spreading Prediction and Impact Analysis by using Artificial Intelligence for Sustainable Global Health Assessment -- Smart Mucoadhesive Bio-flexy film former from pulp of Magnifera indica and its in-built properties for pharmaceutical applications -- Varietal evaluation in okra for yield and yield attributing traits under mid-hill conditions of Garhwal Himalayas -- Population assessment and Phyto-Chemical screening of Meconopsis aculeata Royle an Endangered Medicinal Plant of Western Himalaya -- Multi Disciplinary Analyses on Hydro Rotor using Computational Hydrodynamic Simulation (CHS) -- Sand-gravel mining as a threat to macro-benthic assemblage and habitat parameters: A case study of river Ganga, India -- Organizational Safety Perfection Survey – A tool to identify and correct organizational contributors for Industrial accidents -- Comparative assessment of performance and emission characteristics of DI diesel engine fueled with combined blending of biodiesel, butanol and conventional diesel.
    Abstract: This book presents the proceedings of the First National Conference on “Sustainable Management of Environment & Natural Resource through Innovation in Science and Technology” (SMTST2020). The book highlights the latest development and innovations in the fields of sustainability, natural resource management, ecology and its environmental fields, geosciences and geology, atmospheric sciences, sustainability, climate change, and extreme weather, global warming, and global change, the effect of climate change on the ecosystem, environment, and pollution, as well as putting a strong emphasis on the multidisciplinary studies.
    Type of Medium: Online Resource
    Pages: XVI, 503 p. 316 illus., 141 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030790653
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    URL: https://doi.org/10.1007/978-3-030-79065-3
    DOI: 10.1007/978-3-030-79065-3
    DDC: 363.73
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    Notch Signaling in Embryology and Cancer : Molecular Biology of Notch Signaling (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    URL: https://doi.org/10.1007/978-3-030-36422-9
    DOI: 10.1007/978-3-030-36422-9
    DDC: 571.978
    Language: English
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    Tumor Microenvironment : Molecular Players – Part B (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    URL: https://doi.org/10.1007/978-3-030-50224-9
    DOI: 10.1007/978-3-030-50224-9
    DDC: 571.978
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    Immunotherapy for Gastrointestinal Malignancies (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-6487-1
    DOI: 10.1007/978-981-15-6487-1
    DDC: 571.978
    Language: English
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    Autophagy in tumor and tumor microenvironment (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    URL: https://doi.org/10.1007/978-981-15-6930-2
    DOI: 10.1007/978-981-15-6930-2
    DDC: 571.978
    Language: English
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