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  • 1
    Electronic Resource
    Electronic Resource
    REGULATION OF TELOMERASE BY TELOMERIC PROTEINS (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 73 (2004), S. 177-208 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Telomeres are essential for genome stability in all eukaryotes. Changes in telomere functions and the associated chromosomal abnormalities have been implicated in human aging and cancer. Telomeres are composed of repetitive sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast), and accessory factors (the Est1 proteins and dyskerin in humans and Est1, Est3, and Sm proteins in budding yeast). Telomerase is regulated in cis by proteins that bind to telomeric DNA. This regulation can take place at the telomere terminus, involving single-stranded DNA-binding proteins (POT1 in humans and Cdc13 in budding yeast), which have been proposed to contribute to the recruitment of telomerase and may also regulate the extent or frequency of elongation. In addition, proteins that bind along the length of the telomere (TRF1/TIN2/tankyrase in humans and Rap1/Rif1/Rif2 in budding yeast) are part of a negative feedback loop that regulates telomere length. Here we discuss the details of telomerase and its regulation by the telomere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.73.071403.160049
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  • 2
    Electronic Resource
    Electronic Resource
    REGULATION OF TELOMERASE BY TELOMERIC PROTEINS (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 73 (2004), S. 177-208 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Telomeres are essential for genome stability in all eukaryotes. Changes in telomere functions and the associated chromosomal abnormalities have been implicated in human aging and cancer. Telomeres are composed of repetitive sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast), and accessory factors (the Est1 proteins and dyskerin in humans and Est1, Est3, and Sm proteins in budding yeast). Telomerase is regulated in cis by proteins that bind to telomeric DNA. This regulation can take place at the telomere terminus, involving single-stranded DNA-binding proteins (POT1 in humans and Cdc13 in budding yeast), which have been proposed to contribute to the recruitment of telomerase and may also regulate the extent or frequency of elongation. In addition, proteins that bind along the length of the telomere (TRF1/TIN2/tankyrase in humans and Rap1/Rif1/Rif2 in budding yeast) are part of a negative feedback loop that regulates telomere length. Here we discuss the details of telomerase and its regulation by the telomere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.73.071403.160049
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  • 3
    Electronic Resource
    Electronic Resource
    Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 1068-1071 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When telomeres are rendered dysfunctional through replicative attrition of the telomeric DNA or by inhibition of shelterin, cells show the hallmarks of ataxia telangiectasia mutated (ATM) kinase signalling. In addition, dysfunctional telomeres might induce an ATM-independent pathway, such as ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06065
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  • 4
    Electronic Resource
    Electronic Resource
    POT1 as a terminal transducer of TRF1 telomere length control (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 423 (2003), S. 1013-1018 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Human telomere maintenance is essential for the protection of chromosome ends, and changes in telomere length have been implicated in ageing and cancer. Human telomere length is regulated by the TTAGGG-repeat-binding protein TRF1 and its interacting partners tankyrase 1, TIN2 and PINX1 (refs ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01688
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  • 5
    Electronic Resource
    Electronic Resource
    Ending up with the right partner (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 392 (1998), S. 753-754 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] How do the correct maternal and paternal chromosomes find one another during sexual reproduction? New data from fission yeast indicate that the search for the right partner is simplified by pre-alignment of the chromosomes through clustering of their ends. Arguably the most intimate event ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/33790
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  • 6
    Electronic Resource
    Electronic Resource
    Control of telomere length by the human telomeric protein TRF1 (1997)
    [s.l.] : Nature Publishing Group
    Nature 385 (1997), S. 740-743 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 Tetracyclin-regulated expression of TRF1 proteins in HT1080 cells, a, Domain structure of TRF1 proteins used in this study. NLS, putative nuclear localization signal, b, Western analysis of inducible TRF1 expression in HTC75 clones. Whole-cell extracts from induced and uninduced cells were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/385740a0
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  • 7
    Electronic Resource
    Electronic Resource
    TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 618-623 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Telomere length in humans is partly controlled by a feedback mechanism in which telomere elongation by telomerase is limited by the accumulation of the TRF1 complex at chromosome ends. TRF1 itself can be inhibited by the poly(ADP-ribose) polymerase (PARP) activity of its interacting partner ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1360
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  • 8
    Electronic Resource
    Electronic Resource
    Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2 (1997)
    [s.l.] : Nature Publishing Group
    Nature genetics 17 (1997), S. 231-235 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] An anonymous cDNA fragment encoding a TRF1-related Myb motif was reported in the database8. This sequence information was used in a combination of polymerase chain reaction (PCR) and hybridization strategies to isolate the full-length human and mouse cDNAs representing this protein (called TRF2, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1097-231
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  • 9
    Electronic Resource
    Electronic Resource
    Telomere protection by mammalian Pot1 requires interaction with Tpp1 (2007)
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 14 (2007), S. 754-761 
    Details
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The shelterin complex at mammalian telomeres contains the single-stranded DNA–binding protein Pot1, which regulates telomere length and protects chromosome ends. Pot1 binds Tpp1, the shelterin component that connects Pot1 to the duplex telomeric DNA–binding proteins Trf1 and Trf2. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsmb1270
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  • 10
    Electronic Resource
    Electronic Resource
    Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 451-453 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The physical maps of the BCs and ELCs of VSG genes 117 and 118 are shown in Fig. 1. The regions surrounding both ELCs are indistinguishable and both genes may have been inserted into the same expression site. This site is characterized by long stretches of DNA in which no restriction enzymes cut. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299451a0
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