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  • 1
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    A deep/wide 1-2 GHz snapshot survey of SDSS Stripe 82 using the Karl G. Jansky Very Large Array in a compact hybrid configuration (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-30
    Description: We have used the Karl G. Jansky Very Large Array to image ~100 deg 2 of SDSS Stripe 82 at 1–2 GHz. The survey consists of 1026 snapshot observations of 2.5 min duration, using the hybrid CnB configuration. The survey has good sensitivity to diffuse, low surface brightness structures and extended radio emission, making it highly synergistic with existing 1.4 GHz radio observations of the region. The principal data products are continuum images, with 16  x  10 arcsec resolution, and a catalogue containing 11 782 point and Gaussian components resulting from fits to the thresholded Stokes-I brightness distribution, forming approximately 8948 unique radio sources. The typical effective 1 noise level is 88 μJy beam –1 . Spectral index estimates are included, as derived from the 1 GHz of instantaneous bandwidth. Astrometric and photometric accuracy are in excellent agreement with existing narrowband observations. A large-scale simulation is used to investigate clean bias, which we extend into the spectral domain. Clean bias remains an issue for snapshot surveys with the VLA, affecting our total intensity measurements at the ~1 level. Statistical spectral index measurements are in good agreement with existing measurements derived from matching separate surveys at two frequencies. At flux densities below ~35 the median in-band spectral index measurements begin to exhibit a bias towards flatness that is dependent on both flux density and the intrinsic spectral index. In-band spectral curvature measurements are likely to be unreliable for all but the very brightest components. Image products and catalogues are publicly available via an FTP server.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 2
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    Sex-specific regulation of Lgr3 [Genetics] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-03-02
    Description: The development of sexually dimorphic morphology and the potential for sexually dimorphic behavior in Drosophila are regulated by the Fruitless (Fru) and Doublesex (Dsx) transcription factors. Several direct targets of Dsx have been identified, but direct Fru targets have not been definitively identified. We show that Drosophila leucine-rich repeat G...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Unusual field dependence of spin fluctuations on different timescales in Tb_{2}Ti_{2}O_{7} (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-09-20
    Description: Author(s): P. J. Baker, M. J. Matthews, S. R. Giblin, P. Schiffer, C. Baines, and D. Prabhakaran We have investigated the spin dynamics of Tb 2 Ti 2 O 7 as a function of magnetic field applied along the [111] axis using ac susceptibilty and muon-spin relaxation measurements. We find a significant increase in the imaginary part of the magnetic susceptibility at low fields at our lowest investigated t... [Phys. Rev. B 86, 094424] Published Wed Sep 19, 2012
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-01-20
    Description: Mitochondrial morphology is shaped by fusion and division of their membranes. Here, we found that adult myocardial function depends on balanced mitochondrial fusion and fission, maintained by processing of the dynamin-like guanosine triphosphatase OPA1 by the mitochondrial peptidases YME1L and OMA1. Cardiac-specific ablation of Yme1l in mice activated OMA1 and accelerated OPA1 proteolysis, which triggered mitochondrial fragmentation and altered cardiac metabolism. This caused dilated cardiomyopathy and heart failure. Cardiac function and mitochondrial morphology were rescued by Oma1 deletion, which prevented OPA1 cleavage. Feeding mice a high-fat diet or ablating Yme1l in skeletal muscle restored cardiac metabolism and preserved heart function without suppressing mitochondrial fragmentation. Thus, unprocessed OPA1 is sufficient to maintain heart function, OMA1 is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wai, Timothy -- Garcia-Prieto, Jaime -- Baker, Michael J -- Merkwirth, Carsten -- Benit, Paule -- Rustin, Pierre -- Ruperez, Francisco Javier -- Barbas, Coral -- Ibanez, Borja -- Langer, Thomas -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):aad0116. doi: 10.1126/science.aad0116.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. ; INSERM UMR 1141, Hopital Robert Debre, Paris, France. Universite Paris 7, Faculte de Medecine Denis Diderot, Paris, France. ; Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. Department of Cardiology, Instituto de Investigacion Sanitaria (IIS), Fundacion Jimenez Diaz Hospital, Madrid, Spain. thomas.langer@uni-koeln.de bibanez@cnic.es. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. thomas.langer@uni-koeln.de bibanez@cnic.es.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785494" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathy, Dilated/genetics/metabolism/pathology ; Diet, High-Fat ; Embryonic Development ; Female ; GTP Phosphohydrolases ; Gene Deletion ; Heart/embryology ; Heart Failure/genetics/*metabolism/pathology ; Male ; Metalloendopeptidases/genetics ; Metalloproteases/genetics/metabolism ; Mice ; Mice, Knockout ; Mitochondria, Heart/*metabolism/ultrastructure ; *Mitochondrial Degradation ; *Mitochondrial Dynamics ; Mitochondrial Proteins/genetics/metabolism ; Muscle, Skeletal/enzymology ; Myocardium/*metabolism/pathology ; Myocytes, Cardiac/enzymology/pathology ; Proteolysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    The impact of experimental design choices on parameter inference for models of growing cell colonies (2018)
    Royal Society
    Details
    Publication Date: 2018-08-30
    Description: To better understand development, repair and disease progression, it is useful to quantify the behaviour of proliferative and motile cell populations as they grow and expand to fill their local environment. Inferring parameters associated with mechanistic models of cell colony growth using quantitative data collected from carefully designed experiments provides a natural means to elucidate the relative contributions of various processes to the growth of the colony. In this work, we explore how experimental design impacts our ability to infer parameters for simple models of the growth of proliferative and motile cell populations. We adopt a Bayesian approach, which allows us to characterize the uncertainty associated with estimates of the model parameters. Our results suggest that experimental designs that incorporate initial spatial heterogeneities in cell positions facilitate parameter inference without the requirement of cell tracking, while designs that involve uniform initial placement of cells require cell tracking for accurate parameter inference. As cell tracking is an experimental bottleneck in many studies of this type, our recommendations for experimental design provide for significant potential time and cost savings in the analysis of cell colony growth.
    Keywords: theoretical biology, biomathematics, applied mathematics
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 6
    Electronic Resource
    Electronic Resource
    Microdetermination of Methyl Groups Attached to Carbon (1956)
    s.l. : American Chemical Society
    Analytical chemistry 28 (1956), S. 1304-1308 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60116a021
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous Determination of Total Carbon and Carbon-14 Activity (1955)
    s.l. : American Chemical Society
    Analytical chemistry 27 (1955), S. 795-797 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60101a028
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  • 8
    Electronic Resource
    Electronic Resource
    Basal complex of Fuerteventura (Canary Islands) is an oceanic intrusive complex with rift-system affinities (1975)
    [s.l.] : Nature Publishing Group
    Nature 257 (1975), S. 469-471 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The most obvious feature of the complex is the striking dyke swarm in which the dyke intensity sometimes reaches 100%. The oldest rocks seen at the present erosion level form the host rock to the dyke swarm and comprise basic and alkaline rocks of plutonic aspect together with marine sedimentary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/257469a0
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  • 9
    Electronic Resource
    Electronic Resource
    A METHOD FOR EVALUATING ANTITUBERCULAR ACTIVITY IN MICE (1949)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 52 (1949), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1949.tb53957.x
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  • 10
    Electronic Resource
    Electronic Resource
    COMPARATIVE BIOLOGICAL STUDIES OF POLYMYXIN AND “AEROSPORIN” (1949)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 51 (1949), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1949.tb27314.x
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