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  • BIOTECHNOLOGY  (2)
  • bisantrene  (2)
  • somatic embryogenesis  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Characterization of the pharmacokinetics of bisantrene (NSC-337766) (1983)
    Springer
    Investigational new drugs 1 (1983), S. 253-258 
    Details
    ISSN: 1573-0646
    Schlagwort(e): bisantrene ; CL216,942 ; pharmacokinetics in humans
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of bisantrene, 9,10-anthracenedicarboxaldehyde bis ((4,5-dihydro-1 H-imidazol-2-yl) hydrazone) dihydrochloride were evaluated during a Phase I clinical investigation. Bisantrene at doses of 20 to 280 mg/m2 was administered by variable infusion rates to nine patients with advanced metastatic cancer. Bisantrene's plasma clearance followed a triexponential pattern with a harmonic mean terminal half-life (t1/2 γ) of 26 h. The steady state volume of distribution (Vd ss ) was large, averaging 627 l/m2. Plasma clearance averaged 42.6±6.7 l/h/m2. The cumulative urinary excretion of bisantrene was 3.6±1.6% at 48 h.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00208899
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    In vitro regeneration in Trifolium. 1. Direct somatic embryogenesis in T. rubens (L.) (1988)
    Springer
    Plant cell, tissue and organ culture 15 (1988), S. 33-45 
    Details
    ISSN: 1573-5044
    Schlagwort(e): somatic embryogenesis ; tissue culture ; histology ; Trifolium ; zygotic embryogenesis ; regeneration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The origin and development of zygotic and somatic embryos of Trifolium rubens L. was studied with the aid of paraffin sections and light microscopy. Zygotic embryos were collected, fixed and prepared daily from one to ten days after cross-pollination. Somatic embryos were obtained by plating petiole sections on modified L2 medium with 0.015 mgl-1 picloram and 0.1 mgl-1 6-BAP. Cultured petioles were collected and fixed daily from one to 25 days after plating. Two regions in the vascular bundle sheath of cultured petioles gave rise to callus. The first region was adjacent to the phloem fibers and produced friable callus. The second region gave rise to compact callus that was connected to the fascicular cambium. Somatic embryos originated from single cells in the cortex directly without intervening callus formation and from single cells in the friable callus. In addition, embryos arose from meristematic regions in compact callus. Many early stages of embryogenesis (one, two and four-celled stages) were observed in the cortex and friable callus. Zygotic embryogenesis in Trifolium differs from other legumes in that the suspensor is short and has a broad attachment. This arrangement was observed in zygotic embryos of T. rubens and in many somatic embryos. However, a continuum of somatic embryogenesis was observed where some young embryos had a Trifolium suspensor-like arrangement while others were attached to a long narrow suspensor-like structure more characteristic of Medicago.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00039887
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Genotype-dependent whole plant regeneration from protoplasts of red clover (Trifolium pratense L.) (1989)
    Springer
    Plant cell, tissue and organ culture 19 (1989), S. 113-127 
    Details
    ISSN: 1573-5044
    Schlagwort(e): somatic embryogenesis ; plant regeneration ; protoplasts ; Trifolium pratense ; red clover ; protoclonal variation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Protoplasts are useful for subcellular studies, in vitro selection, somatic hybridization and transformation. Whole plant regeneration from protoplasts is a prerequisite to producing altered crop plants using these methods. Whole plant regeneration was achieved from leaf- and suspension culture-derived protoplasts of T. pratense. Regeneration was most dependent upon identifying genotypes with genetic capacity to regenerate. Additional factors that were used to select genotypes, but which proved to be less important, were a high rate of cell growth in culture and a high plating efficiency of protoplasts. One genotype was identified which had a regeneration response equivalent to that of T. rubens and which regenerated from both leaf- and suspension culture-derived protoplasts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00035811
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Anaphylactoid reactions associated with bisantrene infusions (1983)
    Springer
    Investigational new drugs 1 (1983), S. 85-88 
    Details
    ISSN: 1573-0646
    Schlagwort(e): bisantrene ; hypersensitivity ; histamine release
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Nine of ninety-three patients receiving Bisantrene on an every three week schedule developed an anaphylactoid reaction with a variety of symptoms. Most reactions occurred in patients who had multiple exposures to Bisantrene. Investigatiors utilizing Bisantrene in ongoing clinical trials should be aware of this life threatening toxicity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00180195
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 5
    facet.materialart.
    Unbekannt
    Combined photosynthetic regenerative systems (1964)
    In:  CASI
    Details
    Publikationsdatum: 2006-10-26
    Beschreibung: Photosynthesis as regeneration system for space flight
    Schlagwort(e): BIOTECHNOLOGY
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unbekannt
    Study of a photosynthetic gas exchanger, a quantitative repetition of the priestley experiment. (1964)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-05-24
    Beschreibung: Photosynthetic gas exchange experiment using dwarf mouse and illuminated suspension of Chlorella ellipsoidea
    Schlagwort(e): BIOTECHNOLOGY
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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