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  • 1
    Electronic Resource
    Electronic Resource
    Repairing Periodontal Bone Defect with In Vivo Tissue Engineering Bone (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1121-1124 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The purpose of this study was to develop a feasible approach for repairing periodontalbone defects with the in vivo tissue engineering bone incorporated with bioabsorbable PLAmembrane and to provide evidences for the clinical application. Osteoinductive HA/β-TCP sinteredat 1100℃ were implanted in the femur medial muscles in the hind legs of three dogs. Fourweeks after implantation, the in vivo tissue engineering (TE) bone was explanted. Meanwhile,artificial periodontal bone defects of 8mm×6mm were performed on the buccal side of 4th premolarand 1st molar of mandible bilaterally, with the exposure of dental roots. The defects were treated asfollows: (1) in vivo TE bone and PLA membrane; (2) HA/β-TCP ceramics and PLA membrane; (3)PLA membrane only; (4) empty control. At the 2, 4, 8 weeks post-transplantation, the dogs weresacrificed. The specimen were harvested and evaluated by gross inspection, dental radiography,SPECT (99mTC-MDP) and histological observation by MPIA2500. The results showed that moremature osseointegration was found in the group 1. We presumed that the in vivo TE bone graftcould enhance the reparation of periodontal bone defects
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1121.pdf
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Guiding Bone Regeneration with a Novel Biodegradable Polymeric Membrane and Bioceramic Bone Grafts around Dental Implants (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1417-1420 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of this study is to evaluate treatment effects of novel GBR membranes (PDLLAmembranes) applied to bony defects around dental implants on new bone regeneration alone or incombination with bioceramic bone graft (BIO-OSS®) on the mongrel dog model in comparisonwith collagen membrane (BIO-GIDE®) and therefore to assess the clinical values of the novel GBRmembranes and bioceramic bone graft material in dental implantology. 6 implants were placed inbilateral mandibular of each mongrel dog after preparation of mid- crestal defects. The defects onone side were covered with PDLLA membranes alone or with bone graft, while the contra-lateralsides received collagen membranes alone or with bone graft. These animals were sacrificed at 2, 4,8,12 weeks post the GBR-operation. And gross sample examination, standardized radiographs,99mTc-MDP SPECT and histomorphometric analysis were taken. All examinations showed similaramounts of newly formed bone beneath both types of barriers. The PDLLA or collagen membranewith bone graft groups showed better results than the membrane used alone groups. The resultsindicated that PDLLA membranes especially with bioceramic bone graft presented an improvedresponse in dealing with bony defects around implants
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1417.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Exploring the Osteoinductivity of Calcium Phosphate Ceramics/PLA or Collagen Composites (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1638-1641 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The purpose of this study is to explore the osteoinductivity of the composite materials (calciumphosphate ceramics/PLA or collagen composites) with similar physical character of osteoinductivecalcium phosphate ceramics and the influence of the chemical composition of the composite materials onosteoinductivity, and also to provide an experimental evidence for optimizing the design of the compositematerials. Two kinds of composite materials were prepared. One (BCP/PLA) is fabricated with differentratio of BCP (biphasic calcium phosphate) ceramics powder and PDLLA powder through the particulateleachingtechnique. The other (BCP/collagen) is that BCP ceramics sintered at 1250oC and modified withcollagen. The porous materials cylinders with Φ 5×8 mm were prepared. SEM was used to observe themicrostructure and physical morphology of the composite materials. The two groups of compositematerials cylinders were implanted in the dorsal muscles of four dogs. Six samples of each group wereimplanted in each dog respectively. The specimens were harvested at 2, 4, 12 and 24 weeks post operation,and thin decalcified sections were prepared for light microscopy (LM) analysis to evaluate theirosteoinductivity and compare the capability of osteoinduction. The fibro-tissue and bone-like tissue wereobserved in the two composites, but no obvious bone formation was found in the tested periods. Theresults indicated that the composite materials could modify the mechanical property of ceramics.However, if the composite materials were biodegraded soon, new bone could not form into the scaffold,and the calcium phosphate should be the major component of osteoinductive materials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1638.pdf
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  • 4
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    Colloidal stability and drug incorporation aspects of micellar-like PLA–PEG nanoparticles (1999)
    Elsevier
    Details
    Publication Date: 1999-11-01
    Print ISSN: 0927-7765
    Electronic ISSN: 1873-4367
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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