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  • 1
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    The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Cellular response and cell population kinetics were studied during lymphopoiesis in the thymus of the mouse under continuous gamma irradiation using autoradiographic techniques and specific labeling with tritiated thymidine. On the basis of tissue weights, it is concluded that the response of both the thymus and spleen to continuous low dose-rate irradiation is multiphasic. That is, alternating periods of steady state growth, followed by collapse, which in turn is followed by another period of homeostasis. Since there are two populations of lymphocytes - short lived and long-lived, it may be that different phases of steady state growth are mediated by different lymphocytes. The spleen is affected to a greater extent with shorter periods of steady-state growth than exhibited by the thymus.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140114
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 2
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    Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: A comparison study (1975)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: A comparison study was conducted of the effects of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue (white pulp) of the mouse spleen with findings as they relate to the mouse thymus. Experimental techniques employed included autoradiography and specific labeling with tritiated thymidine (TdR-(h-3)). The problem studied involved the mechanism of cell proliferation of lymphoid tissue of the mouse spleen and thymus under the stress of continuous irradiation at a dose rate of 10 roentgens (R) per day for 105 days (15 weeks). The aim was to determine whether or not a steady state or near-steady state of cell population could be established for this period of time, and what compensatory mechanisms of cell population were involved.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-CR-143262
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: A comparison study (1975)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The mechanism of cell proliferation is studied in the lymphoid tissue of the mouse spleen under the stress of continuous irradiation at a dose-rate of 10 roentgens per day for 105 days. Autoradiography and specific labeling with tritiated thymidine were utilized. It was found that at least four compensatory mechanisms maintained a near-steady state of cellular growth: (1) an increase in the proportion of PAS-positive cells which stimulate mitotic activity, (2) maturation arrest of proliferating and differentiating cells which tend to replenish the cells damaged or destroyed by irradiation, (3) an increase in the proportion of cells proliferating, and (4) an increase in the proportion of precursor cells. The results are compared to previous findings observed in the thymus.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-CR-142068
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue (1973)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The problem studied involved cell proliferation in mice thymus undergoing irradiation at a dose rate of 10 roetgens/day for 105 days. Specifically, the aim was to determine wheather or not a steady state of cell population can be established for the indicated period of time and what compensatory mechanisms of cell population are involved.
    Keywords: BIOSCIENCES
    Type: NASA-CR-135723 , SASR-4
    Format: application/pdf
    Location Call Number Expected Availability
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    NASA TECHNICAL REPORTS
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