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The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissueCellular response and cell population kinetics were studied during lymphopoiesis in the thymus of the mouse under continuous gamma irradiation using autoradiographic techniques and specific labeling with tritiated thymidine. On the basis of tissue weights, it is concluded that the response of both the thymus and spleen to continuous low dose-rate irradiation is multiphasic. That is, alternating periods of steady state growth, followed by collapse, which in turn is followed by another period of homeostasis. Since there are two populations of lymphocytes - short lived and long-lived, it may be that different phases of steady state growth are mediated by different lymphocytes. The spleen is affected to a greater extent with shorter periods of steady-state growth than exhibited by the thymus.
Document ID
19740025416
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Foster, B. R. (Grambling Coll. LA, United States)
Date Acquired
September 3, 2013
Publication Date
October 4, 1974
Subject Category
Biosciences
Report/Patent Number
NASA-CR-140114
Accession Number
74N33529
Funding Number(s)
CONTRACT_GRANT: NGR-19-011-008
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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