ALBERT

Description: Oligomerization of a peptide was attempted in a flow reactor that simulated a submarine hydrothermal system. When fluid containing glycine repeatedly circulated through the hot and cold regions in the reactor, oligopeptides were made from glycine. When divalent ions (such as copper ions) were added under acidic conditions, oligoglycine was elongated up to hexaglycine. This observation suggests that prebiotic monomers could have oligomerized in the vicinity of submarine hydrothermal vents on primitive Earth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Imai, E -- Honda, H -- Hatori, K -- Brack, A -- Matsuno, K -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):831-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of BioEngineering, Nagaoka University of Technology, Nagaoka 940-2188, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9933163" target="_blank"〉PubMed〈/a〉

Description: Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above 6 x 10(19) electron volts and the positions of active galactic nuclei (AGN) lying within approximately 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest-energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pierre Auger Collaboration -- Abraham, J -- Abreu, P -- Aglietta, M -- Aguirre, C -- Allard, D -- Allekotte, I -- Allen, J -- Allison, P -- Alvarez, C -- Alvarez-Muniz, J -- Ambrosio, M -- Anchordoqui, L -- Andringa, S -- Anzalone, A -- Aramo, C -- Argiro, S -- Arisaka, K -- Armengaud, E -- Arneodo, F -- Arqueros, F -- Asch, T -- Asorey, H -- Assis, P -- Atulugama, B S -- Aublin, J -- Ave, M -- Avila, G -- Backer, T -- Badagnani, D -- Barbosa, A F -- Barnhill, D -- Barroso, S L C -- Bauleo, P -- Beatty, J -- Beau, T -- Becker, B R -- Becker, K H -- Bellido, J A -- Benzvi, S -- Berat, C -- Bergmann, T -- Bernardini, P -- Bertou, X -- Biermann, P L -- Billoir, P -- Blanch-Bigas, O -- Blanco, F -- Blasi, P -- Bleve, C -- Blumer, H -- Bohacova, M -- Bonifazi, C -- Bonino, R -- Boratav, M -- Brack, J -- Brogueira, P -- Brown, W C -- Buchholz, P -- Bueno, A -- Busca, N G -- Caballero-Mora, K S -- Cai, B -- Camin, D V -- Caruso, R -- Carvalho, W -- Castellina, A -- Catalano, O -- Cataldi, G -- Cazon-Boado, L -- Cester, R -- Chauvin, J -- Chiavassa, A -- Chinellato, J A -- Chou, A -- Chye, J -- Clark, P D J -- Clay, R W -- Colombo, E -- Conceicao, R -- Connolly, B -- Contreras, F -- Coppens, J -- Cordier, A -- Cotti, U -- Coutu, S -- Covault, C E -- Creusot, A -- Cronin, J -- Dagoret-Campagne, S -- Daumiller, K -- Dawson, B R -- de Almeida, R M -- De Donato, C -- de Jong, S J -- De La Vega, G -- de Mello Junior, W J M -- de Mello Neto, J R T -- De Mitri, I -- de Souza, V -- Del Peral, L -- Deligny, O -- Selva, A Della -- Fratte, C Delle -- Dembinski, H -- Di Giulio, C -- Diaz, J C -- Dobrigkeit, C -- D'Olivo, J C -- Dornic, D -- Dorofeev, A -- Dos Anjos, J C -- Dova, M T -- D'Urso, D -- Duvernois, M A -- Engel, R -- Epele, L -- Erdmann, M -- Escobar, C O -- Etchegoyen, A -- Facal San Luis, P -- Falcke, H -- Farrar, G -- Fauth, A C -- Fazzini, N -- Fernandez, A -- Ferrer, F -- Ferry, S -- Fick, B -- Filevich, A -- Filipcic, A -- Fleck, I -- Fonte, R -- Fracchiolla, C E -- Fulgione, W -- Garcia, B -- Garcia Gamez, D -- Garcia-Pinto, D -- Garrido, X -- Geenen, H -- Gelmini, G -- Gemmeke, H -- Ghia, P L -- Giller, M -- Glass, H -- Gold, M S -- Golup, G -- Albarracin, F Gomez -- Berisso, M Gomez -- Herrero, R Gomez -- Goncalves, P -- Goncalves do Amaral, M -- Gonzalez, D -- Gonzalez, J G -- Gonzalez, M -- Gora, D -- Gorgi, A -- Gouffon, P -- Grassi, V -- Grillo, A -- Grunfeld, C -- Guardincerri, Y -- Guarino, F -- Guedes, G P -- Gutierrez, J -- Hague, J D -- Hamilton, J C -- Hansen, P -- Harari, D -- Harmsma, S -- Harton, J L -- Haungs, A -- Hauschildt, T -- Healy, M D -- Hebbeker, T -- Heck, D -- Hojvat, C -- Holmes, V C -- Homola, P -- Horandel, J -- Horneffer, A -- Horvat, M -- Hrabovsky, M -- Huege, T -- Iarlori, M -- Insolia, A -- Ionita, F -- Italiano, A -- Kaducak, M -- Kampert, K H -- Keilhauer, B -- Kemp, E -- Kieckhafer, R M -- Klages, H O -- Kleifges, M -- Kleinfeller, J -- Knapik, R -- Knapp, J -- Koang, D-H -- Kopmann, A -- Krieger, A -- Kromer, O -- Kumpel, D -- Kunka, N -- Kusenko, A -- La Rosa, G -- Lachaud, C -- Lago, B L -- Lebrun, D -- Lebrun, P -- Lee, J -- Leigui de Oliveira, M A -- Letessier-Selvon, A -- Leuthold, M -- Lhenry-Yvon, I -- Lopez, R -- Lopez Aguera, A -- Lozano Bahilo, J -- Maccarone, M C -- Macolino, C -- Maldera, S -- Malek, M -- Mancarella, G -- Mancenido, M E -- Mandat, D -- Mantsch, P -- Mariazzi, A G -- Maris, I C -- Martello, D -- Martinez, J -- Martinez Bravo, O -- Mathes, H J -- Matthews, J -- Matthews, J A J -- Matthiae, G -- Maurizio, D -- Mazur, P O -- McCauley, T -- McEwen, M -- McNeil, R R -- Medina, M C -- Medina-Tanco, G -- Meli, A -- Melo, D -- Menichetti, E -- Menschikov, A -- Meurer, Chr -- Meyhandan, R -- Micheletti, M I -- Miele, G -- Miller, W -- Mollerach, S -- Monasor, M -- Monnier Ragaigne, D -- Montanet, F -- Morales, B -- Morello, C -- Moreno, E -- Moreno, J C -- Morris, C -- Mostafa, M -- Muller, M A -- Mussa, R -- Navarra, G -- Navarro, J L -- Navas, S -- Nellen, L -- Newman-Holmes, C -- Newton, D -- Thi, T Nguyen -- Nierstenhofer, N -- Nitz, D -- Nosek, D -- Nozka, L -- Oehlschlager, J -- Ohnuki, T -- Olinto, A -- Olmos-Gilbaja, V M -- Ortiz, M -- Ostapchenko, S -- Otero, L -- Pakk Selmi-Dei, D -- Palatka, M -- Pallotta, J -- Parente, G -- Parizot, E -- Parlati, S -- Pastor, S -- Patel, M -- Paul, T -- Pavlidou, V -- Payet, K -- Pech, M -- Pekala, J -- Pelayo, R -- Pepe, I M -- Perrone, L -- Petrera, S -- Petrinca, P -- Petrov, Y -- Ngoc, Dieppham -- Ngoc, Dongpham -- Pham Thi, T N -- Pichel, A -- Piegaia, R -- Pierog, T -- Pimenta, M -- Pinto, T -- Pirronello, V -- Pisanti, O -- Platino, M -- Pochon, J -- Porter, T A -- Privitera, P -- Prouza, M -- Quel, E J -- Rautenberg, J -- Reucroft, S -- Revenu, B -- Rezende, F A S -- Ridky, J -- Riggi, S -- Risse, M -- Riviere, C -- Rizi, V -- Roberts, M -- Robledo, C -- Rodriguez, G -- Rodriguez Frias, D -- Rodriguez Martino, J -- Rodriguez Rojo, J -- Rodriguez-Cabo, I -- Ros, G -- Rosado, J -- Roth, M -- Rouille-d'Orfeuil, B -- Roulet, E -- Rovero, A C -- Salamida, F -- Salazar, H -- Salina, G -- Sanchez, F -- Santander, M -- Santo, C E -- Santos, E M -- Sarazin, F -- Sarkar, S -- Sato, R -- Scherini, V -- Schieler, H -- Schmidt, F -- Schmidt, T -- Scholten, O -- Schovanek, P -- Schussler, F -- Sciutto, S J -- Scuderi, M -- Segreto, A -- Semikoz, D -- Settimo, M -- Shellard, R C -- Sidelnik, I -- Siffert, B B -- Sigl, G -- De Grande, N Smetniansky -- Smialkowski, A -- Smida, R -- Smith, A G K -- Smith, B E -- Snow, G R -- Sokolsky, P -- Sommers, P -- Sorokin, J -- Spinka, H -- Squartini, R -- Strazzeri, E -- Stutz, A -- Suarez, F -- Suomijarvi, T -- Supanitsky, A D -- Sutherland, M S -- Swain, J -- Szadkowski, Z -- Takahashi, J -- Tamashiro, A -- Tamburro, A -- Tascau, O -- Tcaciuc, R -- Thomas, D -- Ticona, R -- Tiffenberg, J -- Timmermans, C -- Tkaczyk, W -- Todero Peixoto, C J -- Tome, B -- Tonachini, A -- Torresi, D -- Travnicek, P -- Tripathi, A -- Tristram, G -- Tscherniakhovski, D -- Tueros, M -- Tunnicliffe, V -- Ulrich, R -- Unger, M -- Urban, M -- Valdes Galicia, J F -- Valino, I -- Valore, L -- van den Berg, A M -- van Elewyck, V -- Vazquez, R A -- Veberic, D -- Veiga, A -- Velarde, A -- Venters, T -- Verzi, V -- Videla, M -- Villasenor, L -- Vorobiov, S -- Voyvodic, L -- Wahlberg, H -- Wainberg, O -- Waldenmaier, T -- Walker, P -- Warner, D -- Watson, A A -- Westerhoff, S -- Wieczorek, G -- Wiencke, L -- Wilczynska, B -- Wilczynski, H -- Wileman, C -- Winnick, M G -- Wu, H -- Wundheiler, B -- Xu, J -- Yamamoto, T -- Younk, P -- Zas, E -- Zavrtanik, D -- Zavrtanik, M -- Zech, A -- Zepeda, A -- Ziolkowski, M -- Kegl, B -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):938-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991855" target="_blank"〉PubMed〈/a〉

Description: The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic environment of the old animals. We also show that this lineage conversion is associated with an activation of the canonical Wnt signaling pathway in aged myogenic progenitors and can be suppressed by Wnt inhibitors. Furthermore, components of serum from aged mice that bind to the Frizzled family of proteins, which are Wnt receptors, may account for the elevated Wnt signaling in aged cells. These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brack, Andrew S -- Conboy, Michael J -- Roy, Sudeep -- Lee, Mark -- Kuo, Calvin J -- Keller, Charles -- Rando, Thomas A -- AG23806/AG/NIA NIH HHS/ -- DK069989/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 10;317(5839):807-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17690295" target="_blank"〉PubMed〈/a〉

Description: A Pennsylvanian arborescent lycopod cone, Lepidostrobus schopfii, has microspores that have been found to have intracellular features that are interpreted as nuclei and mitotic chromosomes. The cellularized gametophytes conform to the early stages of growth that occur in modern Selaginella microgametophytes. Since the megagametophyte of L. schopfii is similar in development to extant species of Isoetes, the fossil now is known to have portions of its life cycle in common with both Selaginella and Isoetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brack-Hanes, S D -- Vaughn, J C -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1383-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17736322" target="_blank"〉PubMed〈/a〉