ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Two new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the β allele of the maternally transmitted factor, Mtf, which were previously thought to be Mta-negative. The other is associated with a new allele, Mtfγ, and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomal Mrfα, the new forms are also dependent on the α allele of Hmt, a chromosomal gene linked to H-2. and are associated with β2-microglobulin. Killers could be raised in all six combinations of a, β, and γ mice, showing that each form of Mtf determines a distinct (set of) epitope(s). We propose that the product of the Hmt gene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target antigen, Mta.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1990.tb00857.x
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