Summary
We have localised a dystrophin-related autosomal gene called DMDL (Duchenne muscular dystrophy-like) to human chromosome 6q24 by in situ hybridisation. Using restriction fragment length polymorphism analysis in two mouse species, we have localised the homologous gene Dmdl in the mouse to chromosome 10 proximal to the Myb oncogene. A neuromuscular disease locus dystrophia muscularis (dy) has previously been assigned to this region of mouse chromosome 10.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bradley WG, Jenkison M (1973) Abnormalities of peripheral nerves in murine muscular dystrophy. J Neurol Sci 18:227–247
Buckle VJ, Craig IW (1986) In situ hybridisation. In: Davies KE (ed) Human genetic diseases. IRL Press, Oxford, pp 85–100
Dutrillaux B, Viegas-Pequignot E (1981) High resolution R- and G-banding on the same preparation. Hum Genet 57:93–95
Guenet J-L, Simon-Chazottes D, Avner PR (1988) The use of interspecific mouse crosses for gene localization: present status and future perspectives. Potter ed Curr Top Microbiol Immunol 137:13–17
Kanno H, Huang I-Y, Kan YW, Yoshida A (1989) Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase. Cell 58:595–606
Koenig M, Monaco AP, Kunkel LM (1988) The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell 53:219–228
Love DR, Hill DF, Dickson G, Spurr NK, Byth BC, Marsden RF, Walsh FS, Edwards YH, Davies KE (1989) An autosomal transcript in skeletal muscle with homology to dystrophin. Nature 339:55–58
Lyon M (1989) Mouse chromosome atlas. Mouse Newslett 84:24–45
Mitchell M, Simon D, Affara N, Ferguson-Smith M, Avner P, Bishop C (1989) Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region. Genetics 121:803–809
Searle AG, Peters J, Lyon MF, Hall JG, Evans EP, Edwards JH, Buckle VJ (1989) Chromosome maps of man and mouse. IV. Ann Hum Genet 53:89–140
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 38:503
Watkins SC, Hoffman EP, Slayter HS, Kunkel LM (1988) Immunoelectron microscopic localization of dystrophin in myofibres. Nature 333:863–866
Zubrzycka-Gaarn EE, Bulman DE, Karpati G, Burghes AHM, Belfall B, Klamut HJ, Talbot J, Hodges RS, Ray PN, Worton RG (1988) The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle. Nature 333:466–469
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Buckle, V.J., Guenet, J.L., Simon-Chazottes, D. et al. Localisation of a dystrophin-related autosomal gene to 6q24 in man, and to mouse chromosome 10 in the region of the dystrophia muscularis (dy) locus. Hum Genet 85, 324–326 (1990). https://doi.org/10.1007/BF00206755
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00206755