ISSN:
0749-1581
Keywords:
Amiodarone
;
Desethylamiodarone
;
Desoxoamiodarone
;
1H NMR
;
13C NMR
;
Selective INEPT
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H and 13C NMR spectra of amiodarone, a potent cardiac antiarrhythmic agent, desethylamiodarone, the main metabolite of amiodarone and desoxoamiodarone, a less toxic form of amiodarone, were assigned using a combination of NMR techniques. Methods applied include 1H-1H COSY, homonuclear Hartmann-Hahn relayed spectroscopy (HOHAHA), broadband decoupled 1H-13C chemical shift correlation, long-range 1H-13C chemical shift correlation and selective INEPT. This combination of NMR experiments has completed a molecular walk along the covalent framework of the cardiac drug molecules, and removed ambiguities in their 1H and 13C NMR assignments.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290513
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