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  • 1
    Electronic Resource
    Electronic Resource
    Preparation and properties of dioxomolybdenum alkoxides, phenoxide, and siloxides prepared by the cocondensation reaction of molybdenum trioxide with alkoxy- or (aryloxy)silanes (1989)
    s.l. : American Chemical Society
    Inorganic chemistry 28 (1989), S. 1279-1283 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00306a015
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  • 2
    Electronic Resource
    Electronic Resource
    FUNCTION, STRUCTURE, AND MECHANISM OF INTRACELLULAR COPPER TRAFFICKING PROTEINS (2001)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 70 (2001), S. 677-701 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract Genetic, biochemical, and spectroscopic studies have established a new function for an intracellular protein, i.e., guiding and inserting a copper cofactor into the active site of a target enzyme. Studies of these new proteins have revealed a fundamental aspect of copper physiology, namely the vast overcapacity of the cytoplasm for copper sequestration. This finding framed the mechanistic, energetic, and structural aspects of intracellular copper trafficking proteins. One hallmark of the copper chaperones is the similarity of the protein fold between the chaperone and its target enzyme. The surface residues presented by each partner, however, are quite different, and some initial findings concerning the complementarity of these interfaces have led to mechanistic insights. The copper chaperones appear to lower the activation barrier for metal transfer into specific protein-binding sites. The manner in which they facilitate metal insertion appears to involve a docking of the metal donor and acceptor sites in close proximity to one another. Although the intimate mechanism is still open, it appears that a low activation barrier for metal transfer is achieved by a network of coordinate-covalent, electrostatic, and hydrogen bonding interactions in the vicinity of the metal-binding site itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.70.1.677
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  • 3
    Electronic Resource
    Electronic Resource
    Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins (2000)
    [s.l.] : Nature America Inc.
    Nature structural biology 7 (2000), S. 766-771 
    Details
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The Hah1 metallochaperone protein is implicated in copper delivery to the Menkes and Wilson disease proteins. Hah1 and the N-termini of its target proteins belong to a family of metal binding domains characterized by a conserved MT/HCXXC sequence motif. The crystal structure of Hah1 has been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/78999
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical and antifungal properties of the copper(II) complexes of 2-formylpyridine4 N-methyl-,4 N-dimethyl,4 N-diethyl and4 N-dipropylthiosemicarbazones (1991)
    Springer
    Transition metal chemistry 16 (1991), S. 565-570 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Two series of copper(II) complexes. [Cu(HL)X2] and [Cu(L)Cl], where HL is a 2-formylpyridine4 N-substituted thiosemicarbazone, L is an anion formed by loss of the2N hydrogen and X=Cl or Br, have been prepared and spectrally characterised. Their growth inhibition ofAspergillus niger andPaecilomyces variotii has been measured and compared with analogous complexes formed from 2-acetylpyridine thiosemicarbazones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01024187
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  • 5
    Electronic Resource
    Electronic Resource
    Transition metal ion complexes of theS-methyldithiocarbazate prepared from 2-acetylpyridineN-oxide (1989)
    Springer
    Transition metal chemistry 14 (1989), S. 190-194 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Metal ion complexes of theS-methyldithiocarbazate of 2-acetylpyridineN-oxide, HONS, have been prepared and characterised by spectral and physical methods. Preparative ethanolic solutions on reflux yield complexes in which the deprotonated form of the ligand, ONS, is complexedvia itsN-oxide oxygen, azomethine nitrogen, and thione sulphur. Representative stoichiometries are as follows: [M(ONS)2]X (M=Fe3+, and X=ClO 4 − , FeCl 4 − or M=Co3+ and X=BF 4 − ) and [M(ONS)X] (M=Co2+, Ni2+ and Cu2+ and X=Cl−, Br−). The i.r., electronic, and electron spin resonance spectra of the complexes are compared to analogous complexes of theX-methyldithiocarbazate of 2-acetylpyridine as well as the thiosemicarbazones of 2-acetylpyridineN-oxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01043792
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  • 6
    Electronic Resource
    Electronic Resource
    Transition metal ion complexes of theS-methyldithiocarbazate prepared from 2-acetylpyridine (1989)
    Springer
    Transition metal chemistry 14 (1989), S. 195-199 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Metal ion complexes of 2-acetylpyridineS-methyldithiocarbazate, HNNS, have been prepared and spectrally characterised. Preparations in EtOH yield complexes in which the deprotonated ligand, NNS, is complexedvia its pyridyl nitrogen, azomethine nitrogen, and thione sulphur. The stoichiometries are: [M(NNS)2]X (M=Fe3+, Co3+ and X=ClO 4 − , [FeCl4]−, BF 4 − , 1/2 [CoCl4]2− and 1/2 [CoBr4]2−), [M(NNS)X] (M=Ni2+, Cu2+ and X=Cl−, Br−), [Cu(NNS)H2O]BF4 and ‘Ni(HNNS)(NNS)F(EtOH)]BF4. The spectral (i.e., i.r., u.v.-vis.-n.i.r. and e.s.r.) and physical properties of these complexes are compared to those of theS-methyldithiocarbazates of 2-formylpyridine and 2-acetylpyridineN-oxide, as well as the related thiosemicarbazones prepared from 2-acetylpyridine. Thermal studies of the nickel(II) complexes indicate that the nature of thermal decomposition of coordinated NNS is different from that of HNNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01043793
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  • 7
    Electronic Resource
    Electronic Resource
    Single- and multiple-dose kinetics of oral lorazepam in humans: The predictability of accumulation (1979)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 7 (1979), S. 159-179 
    Details
    ISSN: 1573-8744
    Keywords: lorazepam ; benzodiazepines ; pharmacokinetics ; drug accumulation ; antipyrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Six healthy volunteers participated in single- and multiple-dose pharmacokinetic studies of oral lorazepam. Following single 4-mg oral doses, peak plasma lorazepam concentrations ranging from 40 to 70 ng/ml were reached within 3 hr of the dose. Values of absorption half-life averaged 25min (range 10.3–42.7min), and elimination half-life (t 1/2β ) averaged 14.2 hr (range 8.4–23.9 hr). During 15 consecutive days of 3 mg per day administered in divided doses, accumulation to the steady-state condition was complete within several days of the initiation of therapy. Values of accumulation half-life (mean 21.1 hr) were slightly longer than t 1/2β , and the two were not well correlated. Observed accumulation ratios (mean 1.88) were very close to those predicted from the single-dose study (mean 1.77), but the correlation between the two (r=0.51) was not significant in the small sample size. “Washout” half-life values (mean 14.9 hr) were highly correlated with t 1/2β (r=0.92). Clearance of a single intravenous dose of antipyrine determined prior to the multiple- dose lorazepam study (mean 0.86 ml/min/kg) was essentially identical to that determined after the study (mean 0.87 ml/min/kg). Overall, the rate and extent of lorazepam accumulation during multiple dosage were reasonably well predicted by the single-dose kinetic study. However, accurate prediction for any specific individual was not always achieved. Stimulation or inhibition by lorazepam of its own clearance probably does not explain imprecise prediction, since single-dose t 1/2β .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059736
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  • 8
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    Fire history of pinyon–juniper woodlands at upper ecotones with ponderosa pine forests in Arizona and New Mexico (2008)
    Canadian Science Publishing
    Details
    Publication Date: 2008-08-01
    Description: We used maps of fire evidence, fire scar dendrochronology, forest age-structure analysis, and landscape analysis to investigate fire history at pinyon pine ( Pinus edulis Engelm.) – juniper ( Juniperus osteosperma (Torr.) Little, Juniperus scopulorum Sarg.) woodland – ponderosa pine ( Pinus ponderosa P. & C. Lawson) forest ecotones in Arizona (Tusayan) and in New Mexico (Canjilon). Results showed that charred trees were not evenly distributed across vegetative communities but were significantly (p 〈 0.001) more abundant than expected in ponderosa pine communities. Composite fire scar analysis indicated that surface fires occurred in ponderosa pine stands at both sites and burned at intervals of 7.2–11.1 years (WMPI; Weibull median probability interval). At Tusayan, landscape structure was fine grained, and maximum pinyon age was 〉200 years across 80% of the site. At Canjilon, landscape pattern was relatively coarse, and most pinyon patches were 200–300 years old. Cumulative standing age distributions suggested pinyon–juniper fire rotations of 340 and 290 years at Tusayan and Canjilon, respectively. We concluded the following: (i) surface fires in ponderosa pine stands did not spread through pinyon–juniper communities at either site, (ii) fire evidence was prevalent across both sites, but old pinyon trees indicated that no widespread lethal fires had occurred in the last 300–400 years, and (iii) structurally heterogeneous landscapes suggested that historical pinyon–juniper fires were of limited extent but lethal in patches.
    Print ISSN: 0045-5067
    Electronic ISSN: 1208-6037
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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  • 9
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    Status of High latitude precipitation estimates from observations and reanalyses (2016)
    Wiley
    Details
    Publication Date: 2016-04-07
    Description: An intercomparison of high-latitude precipitation characteristics from observation-based and reanalysis products is performed. In particular the precipitation products from CloudSat provide an independent assessment to other widely used products, these being the observationally-based GPCP, GPCC and CMAP products and the ERA-Interim, MERRA and NCEP-DOE R2 reanalyses. Seasonal and annual total precipitation in both hemispheres poleward of 55° latitude is considered in all products, and CloudSat is used to assess intensity and frequency of precipitation occurrence by phase, defined as rain, snow or mixed phase. Furthermore, an independent estimate of snow accumulation during the cold season was calculated from the Gravity Recovery and Climate Experiment (GRACE). The intercomparison is performed for the 2007-2010 period when CloudSat was fully operational. It is found that ERA- Interim and MERRA are broadly similar, agreeing more closely with CloudSat over oceans. ERA-Interim also agrees well with CloudSat estimates of snowfall over Antarctica where total snowfall from GPCP and CloudSat is almost identical. A number of disagreements on regional or seasonal scales are identified: CMAP reports much lower ocean precipitation relative to other products, NCEP-DOE R2 reports much higher summer precipitation over northern hemisphere land, GPCP reports much higher snowfall over Eurasia, and CloudSat overestimates precipitation over Greenland, likely due to mischaracterization of rain and mixed-phase precipitation. These outliers are likely unrealistic for these specific regions and time periods. These estimates from observations and reanalyses provide useful insights for diagnostic assessment of precipitation products in high latitudes, quantifying the current uncertainties, improving the products, and establishing a benchmark for assessment of climate models.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
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    IMERG V06: Changes to the Morphing Algorithm (2019)
    American Meteorological Society (AMS)
    Details
    Publication Date: 2019
    Description: Journal of Atmospheric and Oceanic Technology, Ahead of Print. 〈br/〉
    Print ISSN: 0739-0572
    Electronic ISSN: 1520-0426
    Topics: Geography , Geosciences , Physics
    Published by American Meteorological Society (AMS)
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