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  • 1
    Electronic Resource
    Electronic Resource
    Similarity and divergence among rodent repetitive DNA sequences (1989)
    Springer
    Journal of molecular evolution 28 (1989), S. 191-199 
    Details
    ISSN: 1432-1432
    Keywords: Repetitive DNA ; Rodent ; B1 ; B2 ; Species specificity ; Selfish DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have analyzed the sequence of 63 B1 and 71 B2 repetitive elements from published data base sequences. The sequences conform to previously published consensus sequences, but are not identical to them. The B2 sequences show seven regions of high variability between family members, which we show points to the B2 family containing subfamilies; no similar evidence is found for subfamilies of the B1 family. The comparisons show no evidence for the emergence of species-specific variants of B1 or B2 sequences since the separation of murine and hamster lines of descent, nor of their concerted evolution within species in the last 10 million years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02102476
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  • 2
    Electronic Resource
    Electronic Resource
    Codon usage in histone gene families of higher eukaryotes reflects functional rather than phylogenetic relationships (1986)
    Springer
    Journal of molecular evolution 23 (1986), S. 224-241 
    Details
    ISSN: 1432-1432
    Keywords: Sequence alignment ; Nonrandom codon usage ; Histone genes ; Evolutionary model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The nucleic acid sequences coding for 23 H3 histone genes from a variety of species have been analyzed using a computer assisted alignment and analysis program. Although these histones are highly conserved within and between highly divergent species, they represent various classes of histones whose patterns of expression are distinctively regulated. Surprisingly, in dendrograms derived from these comparisons, H3 sequences cluster according to their modes of regulation rather than phylogenetically. These clusters are generated from highly distinctive patterns of codon usage within the functional gene classes. We suggest that one factor involved in specifying the differing codon usage patterns between functional classes is a difference in requirements for rapid translation of mRNA. In addition, the data presented here, together with structural and sequence information, suggest a heterodox evolutionary model in which genes related to the intron-bearing, basally expressed H3.3 vertebrate genes are the ancestors of the intronless H3. 1 class of genes of higher eukaryotes. The H3. 1 class must have arisen, therefore, following duplication of a primitive H3.3 gene, but prior to the plant-animal divergence. Implications of the data presented are discussed with regard to functional and evolutionary relationships.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02115579
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  • 3
    Electronic Resource
    Electronic Resource
    The multiple origins of human Alu sequences (1986)
    Springer
    Journal of molecular evolution 23 (1986), S. 189-199 
    Details
    ISSN: 1432-1432
    Keywords: Repetitive DNA ; Multigene family ; Alu sequences ; Retroposons ; Selfish DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary I have analyzed a collection of published human Alu sequences. The compiled sequences show several unexpected features, including a uniform pattern of divergence from their consensus sequence, a mutual divergence that is not correlated with their age, and common features in the genomic DNA flanking the 5′ ends of the elements. I suggest that the Alu family of sequences derives from a large pool of precursors and not from a single precursor similar to the family consensus sequence, and that new elements integrate into the genome selectively at oligo-A-rich sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02115575
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  • 4
    Electronic Resource
    Electronic Resource
    The parts list of life (2001)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 401-402 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The genome has turned out to be a relatively poor source of explanation for the differences between cells or between people. This was foreseen by certain prescient commentators, who suggested that the genome is far from the answer to all biological questions, powerful as the associated tools of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/88044
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  • 5
    Electronic Resource
    Electronic Resource
    Genetics of schizophrenia (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 402-402 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-As is his wont, Steven Rose (Nature 336, 512; 1988) belittles the efforts of molecular biologists to understand human problems. Rose's objection that "Sher-rington et al, have not shown that [the locus on chromosome 5 to which their RFLP markers are linked] is sufficient [for a person to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/337402a0
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  • 6
    Electronic Resource
    Electronic Resource
    Open source and biotech (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1046-1046 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Your editorial in the June issue (Nat. Biotechnol. 23, 633, 2005) on the biotech open source movement skirted round one critical difference between biotech and the software industry whose 'open source' movement Richard Jefferson seeks to emulate. Writing software is cheap and can be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0905-1046
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  • 7
    Electronic Resource
    Electronic Resource
    Furniture for the shelves? (1996)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 14 (1996), S. 1307-1308 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This encyclopedia of biological molecules is a puzzle. Is it actually meant to be read, or does the editor agree with Sydney Smith that “No furniture is as charming as books, even if you never open them.” For whose education are these words intended? And for whose pocket? The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1096-1307b
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  • 8
    Electronic Resource
    Electronic Resource
    Terminology evolution (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 433-433 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: It is a small point, but could people writing about what David Stone calls “molecular diversity” stop calling the process of selecting random collections of combinatorially synthesized molecules “molecular evolution?”1 “Molecular evolution” means ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0594-433a
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  • 9
    Electronic Resource
    Electronic Resource
    Biotechnology for pleasure and profit (1993)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 11 (1993), S. 1243-1247 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Health care is all very well, but can biotechnology improve the quality of life as well as its ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1193-1243
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  • 10
    Electronic Resource
    Electronic Resource
    Alternative Routes Through the Genome (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 1251-1256 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Like the project that put the first man on the moon, the human genome project has gathered sufficient momentum to advance regardless of its scientific or social merits. Genome projects are now a matter of national prestige. And like the United States' lunar landing program, several less-ambitious ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1290-1251
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