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  • 11
    Electronic Resource
    Electronic Resource
    Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q (1988)
    Springer
    Human genetics 〈Berlin〉 80 (1988), S. 379-381 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The two markers most closely linked to the myotonic dystrophy (DM) locus on chromosome 19 are the gene that codes for apolipoprotein CII (APOC2) and the anonymous probe D19S19 (LDR152). Both of these markers show tight linkage to DM, with maximum lod scores of〉20 at recombination fractions of less than 0.05. We have identified, in a family in which DM segregates, an affected individual where a meiotic recombination event has occurred in which both of these linked markers have crossed over with the gene defect. This demonstrates that APOC2 and D19S19 are probably on the same side of DM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273655
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  • 12
    Electronic Resource
    Electronic Resource
    Pharmacokinetic model based on circulatory transport (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 287-293 
    Details
    ISSN: 1432-1041
    Keywords: linear system theory ; perfusion model ; cardiac output ; pulmonary extraction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Assessment of pharmacokinetics in terms of circulatory drug transport is proposed using the methods of linear system theory. In this model-independent approach drug distribution and disposition are characterized by the total extraction ratio, the mean residence time in the body and the volume of distribution at steady state. In analyzing concentration(c)-time(t) data, the procedure requires calculation only of the areas under the c(t)-and c(t)×t-curves to estimate kinetic parameters, and for prediction of the steady state concentration following continuous infusion or multiple doses. Pulmonary clearance of drugs is included in the theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608408
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  • 13
    Electronic Resource
    Electronic Resource
    Use of gamma distributed residence times in pharmacokinetics (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 695-702 
    Details
    ISSN: 1432-1041
    Keywords: pharmacokinetic theory ; gamma distribution ; residence time ; circulation time ; absorption time ; physiological model ; data evaluation ; concentration-time profil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Using a nonclassical statistically based pharmacokinetic concept, a theory is presented which can be applied to the analysis of concentration-time data fitted by power functions of time C=At−ae−bt, which is shown to be equivalent to the assumption of gamma distributed residence times of drugs. The shape and scale parameters a and b, respectively, are interpreted physiologically in terms of a recirculatory model. It is shown how the shape parameter a, which is only dependent on the coefficient of variation of residence times, is affected by the processes of drug distribution and elimination. The time course of the blood concentration following multiple doses and continuous infusion is predicted for gamma-like drug disposition curves. The assumption of gamma distributed disposition residence times is theoretically based on a random walk model of circulatory drug transport, and the conditions are investigated under which gamma curves can be empirically fitted to oral concentration-time data. The parameters of concentration-time profiles following solid dosage forms, for example, are explained by the means and coefficients of variation of the disposition residence time and dissolution time distribution, respectively. The advantages of this concept compared to the conventional method of fitting sums of exponentials to the data are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542361
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  • 14
    Electronic Resource
    Electronic Resource
    Model-independent assessment of accumulation kinetics based on moments of drug disposition curves (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 355-359 
    Details
    ISSN: 1432-1041
    Keywords: drug accumulation ; reliability theory ; multiple dosing ; curve moments ; mean disposition residence time ; cumulative urinary excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bounds of the accumulation profile can be predicted on the basis of the mean disposition residence time (MDRT) of a drug. The time to reach 90% of the plateau level (t 0.9) is less than 3.7 MDRT. This prediction can be improved if, in addition, the variance of disposition residence time (VDRT, CV D 2 =VDRT/MDRT2), or the terminal exponential coefficient (λ), is known. For CV D 2 →1 or λ MDRT→1, the time to reach steady state (t0.9) approaches 2.3 MDRT (limiting case of monoexponential drug disposition curve). Conditions are stated under which λ can be regarded as the principal determinant of the accumulation rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542175
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  • 15
    Electronic Resource
    Electronic Resource
    Modelling of initial distribution of drugs following intravenous bolus injection (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 121-126 
    Details
    ISSN: 1432-1041
    Keywords: recirculation model ; initial distribution volume ; pharmacokinetic model ; residence time distribution ; cardiac output
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Based on a recirculatory pharmacokinetic model, a physiologically realistic definition of the initial distribution volume has been developed to characterize the overall distribution process occuring shortly after rapid bolus injection of a drug. This apparent volume of distribution, which refers to the peak right atrial blood concentration, depends on the cardiac output and basic pharmacokinetic parameters usually derived from the whole blood concentration vs time curve. The initial distribution process appears to be affected by changes in the variance of the distribution of residence times of the drug in the body. The influence of the site and time of early blood sampling on the estimated initial distribution volume is discussed. This relatively simplea priori model should prove useful in predicting to a first approximation the principal characteristics of the initial distribution process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613938
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  • 16
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of isosorbide-5-nitrate in renal failure (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 349-350 
    Details
    ISSN: 1432-1041
    Keywords: isosorbide-5-nitrate ; renal failure ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the antianginal drug isosorbide-5-nitrate (IS-5-N) was studied in 20 patients with varying degrees of chronic renal failure after repeated oral doses of standard 20 mg tablets t.d.s. Blood samples were taken in the steady state on the 2nd and 28th days, and the plasma level was assayed by HPLC. There was no statistically significant difference in C max ss , t1/2 and AUC 0–8 ss between the 2nd and 28th days, nor was a difference found between patients with mild and severe renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541542
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  • 17
    Electronic Resource
    Electronic Resource
    The relevance of residence time theory to pharmacokinetics (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 571-579 
    Details
    ISSN: 1432-1041
    Keywords: Pharmacokinetics, Residence time ; model, volume of distribution, curve moments, parameter estimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284953
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  • 18
    Electronic Resource
    Electronic Resource
    Rapid achievement of a serum concentration plateau of digoxin through controlled infusion (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 455-457 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; concentration plateau ; pharmacokinetics ; systolic time intervals ; optimal infusion scheme ; dose-response data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Using a volume-controlled infusion pump, a mean serum plateau level of digoxin of 4–5 ng/ml was rapidly achieved and maintained in 6 healthy volunteers. The infusion scheme was calculated on the basis of data published on the pharmacokinetics and pharmacodynamics of digoxin following bolus intravenous injection. The magnitude of the response (change in electromechanical systole) at the end of the plateau phase was comparable to that observed with the concentration in the therapeutic range at steady state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542110
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  • 19
    Electronic Resource
    Electronic Resource
    Radiation enhanced diffusion of Ti in Al2O3 (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 5058-5064 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Titanium bulk and dislocation diffusion coefficients at 1000 °C have been determined for Ti in single crystal α-Al2O3(0001) for three types of samples: (i) Ti evaporated onto Al2O3, (ii) 48Ti+at 100 eV deposited onto Al2O3, and (iii) 48Ti+ at 100 eV deposited onto radiation damaged Al2O3 (damage inflected by implantation of 46Ti+ at 7 keV). Diffusion penetration profiles were obtained by using secondary ion mass spectrometry depth profiling techniques. For the deposited and implanted Ti+ samples, the bulk diffusion coefficients (D) are 5.4×10−21 and 5.6×10−17 m2 s−1, respectively, and dislocation diffusion coefficients are 3.6×10−17 and 1.4×10−12 m2 s−1, respectively. Comparing the D's for Ti in the undamaged and damaged Al2O3, the D's for the latter samples are higher by a factor of 104–105, reflecting the radiation enhanced diffusion due to the defect structure inflected by the implanted 7 keV 46Ti+. Comparing the D's for Ti deposited onto Al2O3 (both the evaporated and 100 eV 48Ti+ samples) with those for Cr deposited onto Al2O3, the Ti D's are larger by a factor of 10, reflecting the influence of the valence state of the cation. These results show that cationic diffusion coefficients in Al2O3 can be controlled by varying the level of defects in the crystal. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1286222
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  • 20
    Electronic Resource
    Electronic Resource
    A Challenging Case for Protein Crystal Structure Determination: the Mating Pheromone Er-1 from Euplotes raikovi (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 469-480 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Four different phasing methods have been applied to the determination of the crystal structure of the 40 amino-acid mating pheromone of the unicellular ciliated protozoan Euplotes raikovi. The difficulties, failures and successes in attempts to solve the structure by: (1) molecular replacement, (2) direct phasing using the `Shake and Bake' algorithm, (3) isomorphous replacement, and (4) multiple-wavelength anomalous disper- sion are described. The structure was first solved by molecular replacement, and then was the first successful structure determination by `Shake and Bake' without the direct involvement of its authors. A description of the current status of the high-resolution refinement of the structure is also given. The model is refined against 1 Å resolution data to an R factor of 12.9%, and includes H atoms and discretely disordered side chains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995014235
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