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  • 11
    Electronic Resource
    Electronic Resource
    Chromosome analysis of bone marrow in mammals after treatment with isoniazid (1978)
    Springer
    Human genetics 〈Berlin〉 42 (1978), S. 15-25 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogenetic investigations in bone marrow from animals treated with isoniazid (INH) were performed in seven different laboratories according to a standard protocol. The experiments were carried out in the Chinese hamster, the mouse, and the rat. In short-term studies INH was administered twice at an interval of 24 h in doses of 5, 25, and 125 mg/kg, and the animals were sacrificed 6, 12, 24, and 48 h after the second dose. In long-term studies doses of 25 and 125 mg/kg were administered thrice weekly for 12 weeks. As a rule, each group consisted of at least four animals, and 100 metaphases per animal were counted. Statistical analysis of the data showed that the incidence of chromosomal aberrations including gaps lay in the critical range for two groups in one laboratory and was significantly higher than in the control in three groups in another of the seven laboratories. From the results of both the short-term and the long-term studies in all laboratories, however, it may be concluded, that isoniazid does not induce gross chromosomal aberrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291618
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  • 12
    Electronic Resource
    Electronic Resource
    Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH) (1978)
    Springer
    Human genetics 〈Berlin〉 42 (1978), S. 50-54 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291623
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  • 13
    Electronic Resource
    Electronic Resource
    The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia (1978)
    Springer
    Human genetics 〈Berlin〉 42 (1978), S. 44-49 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3×125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3–16 mg/kg).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291622
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  • 14
    Electronic Resource
    Electronic Resource
    On glivenko-cantelli convergence (1970)
    Springer
    Probability theory and related fields 16 (1970), S. 195-210 
    Details
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00534596
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  • 15
    Electronic Resource
    Electronic Resource
    Study of the23Na EFG tensor as determined from first order NMR satellite lines near the ferroelectric phase transition of AgNa(NO2)2 (1978)
    Springer
    The European physical journal 31 (1978), S. 187-193 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The23Na NMR first order quadrupolar satellite lines are detected and studied in AgNa(NO2)2 single crystals near the paraelectric-ferroelectric phase transition. Although the intensities of the satellites are small the components of the electric field gradient tensor (EFG) at the23Na sites could be deduced from the angular dependence of the first order quadrupolar line splitting with respect to rotations around the three crystallographic axes by applying the Volkoff method. In the paraelectric phase the principal axes system of the EFG coincides with the crystallographic axes system whereas in the ferroelectric phase there is a strongly temperature dependent small non diagonal elementφ xz (T). The EFG principal componentsφ xx andφ yy are strongly influenced whereas the EFG principal componentφ zz is nearly not affected by the ferroelectric phase transition. The observed temperature dependences of the EFG components are related to the temperature variation of the normalized spontaneous polarizationS(T) by assuming a coupling term which is quadratic inS(T). Finally the problem of the intensities of the satellite lines is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01333891
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  • 16
    Electronic Resource
    Electronic Resource
    A study of branching ratios of cross sections in the charge symmetric reactions10B(d,p)11B and10B(d, n)11C (1973)
    Springer
    The European physical journal 264 (1973), S. 201-210 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract It is shown that the investigation of cross section branching ratios of (d,p) and (d, n) reactions which lead to isobaric analogue states in the residual nuclei may provide some information about reaction mechanism in the low energy region. For the (d, p) and (d, n) reactions on10B the calculation of integrated cross sections by use of DWBA shows that the branching ratio is not so sensitive to the choice of the optical model parameters than angular distribution and absolute cross section. Under the assumption of statistical compound nucleus model the calculated values of branching ratios deviates from those predicted by DWBA, such that the reaction modes can be distinguished. The experimental result is compared with the calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01396276
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  • 17
    Electronic Resource
    Electronic Resource
    NMR of23Na in small particles of ferroelectric NaNO2 (1978)
    Springer
    The European physical journal 32 (1978), S. 83-91 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Pulse and wide line NMR spectroscopy were applied to small ferroelectric NaNO2 particles, produced from aqueous solution and embedded loosely in silicagel. Mean particle diameters as determined by SEM and TEM were between 0.2 and 5.0 µm. From the cw-experiments it followed, that the particles had the crystalline structure of the bulk. It is shown that the spectrum of critical fluctuations and the phase transition temperature in the particles proved to be independent of the size. If there is a “dead layer” at the particle surfaces its thickness does not exceed 1×10−2µm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01322190
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  • 18
    Electronic Resource
    Electronic Resource
    Morphological and cytological abnormalities in a homozygous interchange in Pisum sativum (1976)
    Springer
    Genetica 46 (1976), S. 287-296 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Plants homozygous for an interchange in the long arms of chromosomes 3 and 5 were selected from the progeny of translocated heterozygotes through mitotic chromosome analysis. While a deficit of translocated homozygotes was observed in these segregating families, an increase in the proportion of normal plants was obtained. The translocated homozygotes showed a bushy, dwarfed and weak form coupled with nearly complete sterility. Meiosis turned out to be normal except for the presence of anaphase bridges that occurred in about 10 percent of the pollen mother cells. However, vegetative and floral buds degenerated in the majority of cases before pods developed. In mitosis, anaphase bridges were observed. Their frequency was 30 percent and they were formed by only one of the exchanged chromosomes. Such bridges are considered a consequence of the so-called point errors, which are suggested as the main cause of developmental disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00055472
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  • 19
    Electronic Resource
    Electronic Resource
    Observation of argon lines at normal pressure in the vacuum ultraviolet (1972)
    Springer
    Space science reviews 13 (1972), S. 563-564 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213484
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  • 20
    Electronic Resource
    Electronic Resource
    Der Organzinkgehalt im tierexperimentellen Krankheitsmodell: Dystrophieabhängige Veränderungen in Leber und Skeletmuskel und Einflüsse einer Mineralsubstitution in der Erholungsphase (1979)
    Springer
    European journal of nutrition 18 (1979), S. 286-294 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The zinc content of the liver and the thigh muscle of the rat were measured by means of atomic absorption spectrophotometry under different conditions: standard diet, carbohydrate diet, an experimental dystrophy model and its recovery period. The influence of a parental mineral substitution on the whole body and the organ weight was studied. Carbohydrate diet caused a lower rise of the whole body weight, a decrease of the zinc content of the liver and an increase of the zinc content of the thigh muscle. In dystrophy model, the liver weight decreased to one fifth of the controls. The zinc concentration of the liver increased markedly, the zinc content of the whole liver is equal to that of control animals. The thigh muscle showed an increase of the zinc content, too. The parenteral mineral application had no effect upon the whole body weight and the organ weights. Little influences on the zinc content of the skeletal muscle were seen. The zinc content of parenchymatous organs varies markedly, and it is influenced by diets and disease. In the dystrophy model, zinc is concentrated in atrophic organs in order to protect the organism against zinc deficiency.
    Notes: Zusammenfassung Der Zinkgehalt der Leber und der Oberschenkelmuskulatur der Ratte wurde nach einseitiger Kohlenhydratdiät, einem experimentellen Dystrophiemodell sowie nach dessen Erholungsphase untersucht. Es wurde der Einfluß einer parenteralen Substitution organischer bzw. anorganischer Mineralverbindungen auf das Gesamtkörpergewicht, das Organgewicht und die Organ-Zink-Konzentration verfolgt. Die einseitige Diät führt zu einer retardierten Entwicklung der Versuchstiere und zu einer Umverteilung von Zink aus der Leber in die Skeletmuskulatur. Das Dystrophiemodell reduziert das Lebergewicht durch Atrophie der Hepatozyten auf ein Fünftel des Normalgewichts. Die relative Zinkkonzentration steigt dabei so an, daß der Gesamtzinkgehalt in der Leber unverändert bleibt. In geringerem Ausmaß konzentriert die Skeletmuskulatur Zink in den atrophischen Muskelfasern. In der Erholungsphase hat die parenterale Gabe organischer oder anorganischer Metallverbindungen keinen Einfluß auf das Körpergewicht, das Organgewicht und m. E. den Zinkgehalt der Organe. Die Zinkkonzentrationen der parenchymatösen Organe sind somit Variable, die durch Stoffwechseleinflüsse und Krankheit beeinflußt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020519
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