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Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH)

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Summary

Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.

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References

  • Adler, I.-D.: Comparative cytogenetic study after treatment of mouse spermatogonia with mitomycin C. Mutation Res. 23, 369–379 (1974)

    Google Scholar 

  • Evans, E. P., Breckon, G., Ford, C. E.: An air-drying method for meiotic preparations, from mammalian testes. Cytogenetics 3, 289–294 (1964)

    Google Scholar 

  • Generoso, W. M., Preston, R. J., Brewen, J. G.: 6-Mercaptopurine, an inducer of cytogenetic and dominant lethal effects in premeiotic and early meiotic germ cells of mice. Mutation Res. 28, 437–447 (1975)

    Google Scholar 

  • Leonard, A.: Radiation-induced translocations in spermatogonia of mice. Mutation Res. 11, 71–88 (1971)

    Google Scholar 

  • Leonard, A., Linden, G.: Observation of dividing spermatocytes for chromosome aberrations induced in mouse spermatogonia. Mutation Res. 16, 297–300 (1972)

    Google Scholar 

  • McGaughey, R. W., Chang, M. C.: Initial chromosomal lesions induced by x-irradiating primary spermatocytes of mice. Can. J Genet. Cytol. 15, 341–349 (1973)

    Google Scholar 

  • Rathenberg, R., Müller, D.: Comparative cytogenetic studies on the influence of phenylbutazone and cyclophosphamide on spermatogenesis in the mouse. Agents and Actions 2, 180–186 (1972)

    Google Scholar 

  • Schleiermacher, E.: Über den Einfluß von Trenimon und Endoxan auf die Meiose der männlichen Maus. I. Methodik der Präparation und Analyse meiotischer Teilungen. Humangenetik 3, 127–133 (1966)

    Google Scholar 

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Authors and Affiliations

  1. Abteilung für Genetik, Gesellschaft für Strahlen-und Umweltforschung, Laboratory I, Institut für Biologie, D-8032, Neuherberg bei München, Federal Republic of Germany

    I. -D. Adler & A. Schmaltz

  2. Laboratory II, Institut für Anthropologie und Humangenetik der Universität Heidelberg, D-6900, Heidelberg, Federal Republic of Germany

    R. Rathenberg

  3. Division Pharma, Ciba-Geigy A.G., Laboratory III, Basel, Switzerland

    D. Müller, F. F. Strasser & R. Perret

  4. Biological Research Laboratories of the Pharmaceuticals Division of Ciba-Geigy Limited, Basle, Switzerland

    D. Müller, F. F. Strasser & R. Perret

Authors
  1. I. -D. Adler
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  2. A. Schmaltz
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  3. R. Rathenberg
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  4. D. Müller
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  5. F. F. Strasser
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  6. R. Perret
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Adler, I.D., Schmaltz, A., Rathenberg, R. et al. Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH). Hum Genet 42, 50–54 (1978). https://doi.org/10.1007/BF00291623

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  • DOI: https://doi.org/10.1007/BF00291623

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