ISSN:
1600-5759
Quelle:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Thema:
Chemie und Pharmazie
,
Geologie und Paläontologie
,
Physik
Notizen:
We have determined the crystal structures of two diketopiperazines, cyclo(L-alanyl-L-seryl).H2O, (cis-6-hydroxymethyl-3-methyl-2,5- piperazinedione hydrate, C6H10N2O3.H2O and cyclo(glycyl-L-seryl), 3-hydroxymethyl-2,5-piperazinedione, C5H8N2O3. The crystal structure of cyclo(L-alanyl-L-seryl).H2O [cyclo(L-Ala-L-Ser)] consists of a peptide backbone that is hydrogen bonded to two adjacent diketopiperazine rings, forming extended chains through the crystal. The serine hydroxyl of cyclo(L-Ala-L-Ser) is hydrated by two adjacent water molecules in the crystal. In contrast, the crystal structure of cyclo(Glycyl-L-seryl) [cyclo(Gly L-Ser)] is held together by a three-dimensional network of hydrogen bonds. The serine hydroxyl of cyclo(Gly L-Ser) participates in two hydrogen bonds with the peptide backbone of neighboring molecules.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1107/S0108270195012248
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