Publikationsdatum:
2014-09-19
Beschreibung:
Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suez, Jotham -- Korem, Tal -- Zeevi, David -- Zilberman-Schapira, Gili -- Thaiss, Christoph A -- Maza, Ori -- Israeli, David -- Zmora, Niv -- Gilad, Shlomit -- Weinberger, Adina -- Kuperman, Yael -- Harmelin, Alon -- Kolodkin-Gal, Ilana -- Shapiro, Hagit -- Halpern, Zamir -- Segal, Eran -- Elinav, Eran -- England -- Nature. 2014 Oct 9;514(7521):181-6. doi: 10.1038/nature13793. Epub 2014 Sep 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. ; 1] Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel [2]. ; 1] Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel [2]. ; Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul hospital, Jerusalem Center for Mental Health, Jerusalem 91060, Israel. ; 1] Internal Medicine Department, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel [2] Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel [3] Digestive Center, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel. ; The Nancy and Stephen Grand Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel. ; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel. ; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel. ; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. ; 1] Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel [2] Digestive Center, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25231862" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Anti-Bacterial Agents/pharmacology
;
Aspartame/adverse effects
;
Body Weight/drug effects
;
Diet, High-Fat
;
Dietary Fats/pharmacology
;
Feces/microbiology
;
Female
;
Gastrointestinal Tract/*drug effects/*microbiology
;
Germ-Free Life
;
Glucose/metabolism
;
Glucose Intolerance/*chemically induced/metabolism/*microbiology
;
Humans
;
Male
;
Metabolic Syndrome X/chemically induced/metabolism/microbiology
;
Mice
;
Mice, Inbred C57BL
;
Microbiota/*drug effects
;
Saccharin/administration & dosage/adverse effects
;
Sucrose/adverse effects/analogs & derivatives
;
Sweetening Agents/*adverse effects
;
Waist-Hip Ratio
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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