ISSN:
1432-2242
Schlagwort(e):
Likelihood
;
Peeling
;
Pedigree with loops
;
Segregation analysis
;
Linkage analysis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Abstract This paper presents a new approximation to the likelihood for a pedigree with loops, based on cutting all loops and extending the pedigree at the cuts. An opimum loop-cutting strategy and an iterative extension technique are presented. The likelihood for a pedigree with loops is then approximated by the conditional likelihood for the entire cut-extended pedigree given the extended part. The approximate likelihoods are compared with the exact likelihoods obtained using the program MENDEL for several small pedigrees with loops. The approximation is efficient for large pedigrees with complex loops in terms of computing speed and memory requirements.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00223463
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