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Digitale Medien

Preparation and properties of dioxomolybdenum alkoxides, phenoxide, and siloxides prepared by the cocondensation reaction of molybdenum trioxide with alkoxy- or (aryloxy)silanes (1989)

Kim, Gyu Shik ; Huffman, David ; DeKock, Carroll W.

s.l. : American Chemical Society

Inorganic chemistry 28 (1989), S. 1279-1283

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ISSN: 1520-510X

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/ic00306a015

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Digitale Medien

FUNCTION, STRUCTURE, AND MECHANISM OF INTRACELLULAR COPPER TRAFFICKING PROTEINS (2001)

Huffman, David L. ; O'Halloran, Thomas V.

Palo Alto, Calif. : Annual Reviews

Annual Review of Biochemistry 70 (2001), S. 677-701

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ISSN: 0066-4154

Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Thema: Chemie und Pharmazie , Biologie

Notizen: Abstract Genetic, biochemical, and spectroscopic studies have established a new function for an intracellular protein, i.e., guiding and inserting a copper cofactor into the active site of a target enzyme. Studies of these new proteins have revealed a fundamental aspect of copper physiology, namely the vast overcapacity of the cytoplasm for copper sequestration. This finding framed the mechanistic, energetic, and structural aspects of intracellular copper trafficking proteins. One hallmark of the copper chaperones is the similarity of the protein fold between the chaperone and its target enzyme. The surface residues presented by each partner, however, are quite different, and some initial findings concerning the complementarity of these interfaces have led to mechanistic insights. The copper chaperones appear to lower the activation barrier for metal transfer into specific protein-binding sites. The manner in which they facilitate metal insertion appears to involve a docking of the metal donor and acceptor sites in close proximity to one another. Although the intimate mechanism is still open, it appears that a low activation barrier for metal transfer is achieved by a network of coordinate-covalent, electrostatic, and hydrogen bonding interactions in the vicinity of the metal-binding site itself.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1146/annurev.biochem.70.1.677

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Digitale Medien

Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins (2000)

Wernimont, Amy K. ; Huffman, David L. ; Lamb, Audrey L. ; [weitere]

[s.l.] : Nature America Inc.

Nature structural biology 7 (2000), S. 766-771

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ISSN: 1072-8368

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Hah1 metallochaperone protein is implicated in copper delivery to the Menkes and Wilson disease proteins. Hah1 and the N-termini of its target proteins belong to a family of metal binding domains characterized by a conserved MT/HCXXC sequence motif. The crystal structure of Hah1 has been ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/78999

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4

Digitale Medien

Transition metal ion complexes of theS-methyldithiocarbazate prepared from 2-acetylpyridineN-oxide (1989)

West, Douglas X. ; Huffman, David L.

Springer

Transition metal chemistry 14 (1989), S. 190-194

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ISSN: 1572-901X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Metal ion complexes of theS-methyldithiocarbazate of 2-acetylpyridineN-oxide, HONS, have been prepared and characterised by spectral and physical methods. Preparative ethanolic solutions on reflux yield complexes in which the deprotonated form of the ligand, ONS, is complexedvia itsN-oxide oxygen, azomethine nitrogen, and thione sulphur. Representative stoichiometries are as follows: [M(ONS)2]X (M=Fe3+, and X=ClO 4 − , FeCl 4 − or M=Co3+ and X=BF 4 − ) and [M(ONS)X] (M=Co2+, Ni2+ and Cu2+ and X=Cl−, Br−). The i.r., electronic, and electron spin resonance spectra of the complexes are compared to analogous complexes of theX-methyldithiocarbazate of 2-acetylpyridine as well as the thiosemicarbazones of 2-acetylpyridineN-oxide.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01043792

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Digitale Medien

Transition metal ion complexes of theS-methyldithiocarbazate prepared from 2-acetylpyridine (1989)

West, Douglas X. ; Huffman, David L.

Springer

Transition metal chemistry 14 (1989), S. 195-199

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ISSN: 1572-901X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Metal ion complexes of 2-acetylpyridineS-methyldithiocarbazate, HNNS, have been prepared and spectrally characterised. Preparations in EtOH yield complexes in which the deprotonated ligand, NNS, is complexedvia its pyridyl nitrogen, azomethine nitrogen, and thione sulphur. The stoichiometries are: [M(NNS)2]X (M=Fe3+, Co3+ and X=ClO 4 − , [FeCl4]−, BF 4 − , 1/2 [CoCl4]2− and 1/2 [CoBr4]2−), [M(NNS)X] (M=Ni2+, Cu2+ and X=Cl−, Br−), [Cu(NNS)H2O]BF4 and ‘Ni(HNNS)(NNS)F(EtOH)]BF4. The spectral (i.e., i.r., u.v.-vis.-n.i.r. and e.s.r.) and physical properties of these complexes are compared to those of theS-methyldithiocarbazates of 2-formylpyridine and 2-acetylpyridineN-oxide, as well as the related thiosemicarbazones prepared from 2-acetylpyridine. Thermal studies of the nickel(II) complexes indicate that the nature of thermal decomposition of coordinated NNS is different from that of HNNS.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01043793

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6

Digitale Medien

Chemical and antifungal properties of the copper(II) complexes of 2-formylpyridine4 N-methyl-,4 N-dimethyl,4 N-diethyl and4 N-dipropylthiosemicarbazones (1991)

West, Douglas X. ; Huffman, David L. ; Saleda, Jill S. ; [weitere]

Springer

Transition metal chemistry 16 (1991), S. 565-570

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ISSN: 1572-901X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Two series of copper(II) complexes. [Cu(HL)X2] and [Cu(L)Cl], where HL is a 2-formylpyridine4 N-substituted thiosemicarbazone, L is an anion formed by loss of the2N hydrogen and X=Cl or Br, have been prepared and spectrally characterised. Their growth inhibition ofAspergillus niger andPaecilomyces variotii has been measured and compared with analogous complexes formed from 2-acetylpyridine thiosemicarbazones.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01024187

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7

Digitale Medien

Single- and multiple-dose kinetics of oral lorazepam in humans: The predictability of accumulation (1979)

Greenblatt, David J. ; Allen, Marcia Divoll ; MacLaughlin, Dean S. ; [weitere]

Springer

Journal of pharmacokinetics and pharmacodynamics 7 (1979), S. 159-179

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ISSN: 1573-8744

Schlagwort(e): lorazepam ; benzodiazepines ; pharmacokinetics ; drug accumulation ; antipyrine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract Six healthy volunteers participated in single- and multiple-dose pharmacokinetic studies of oral lorazepam. Following single 4-mg oral doses, peak plasma lorazepam concentrations ranging from 40 to 70 ng/ml were reached within 3 hr of the dose. Values of absorption half-life averaged 25min (range 10.3–42.7min), and elimination half-life (t 1/2β ) averaged 14.2 hr (range 8.4–23.9 hr). During 15 consecutive days of 3 mg per day administered in divided doses, accumulation to the steady-state condition was complete within several days of the initiation of therapy. Values of accumulation half-life (mean 21.1 hr) were slightly longer than t 1/2β , and the two were not well correlated. Observed accumulation ratios (mean 1.88) were very close to those predicted from the single-dose study (mean 1.77), but the correlation between the two (r=0.51) was not significant in the small sample size. “Washout” half-life values (mean 14.9 hr) were highly correlated with t 1/2β (r=0.92). Clearance of a single intravenous dose of antipyrine determined prior to the multiple- dose lorazepam study (mean 0.86 ml/min/kg) was essentially identical to that determined after the study (mean 0.87 ml/min/kg). Overall, the rate and extent of lorazepam accumulation during multiple dosage were reasonably well predicted by the single-dose kinetic study. However, accurate prediction for any specific individual was not always achieved. Stimulation or inhibition by lorazepam of its own clearance probably does not explain imprecise prediction, since single-dose t 1/2β .

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01059736

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Fire history of pinyon–juniper woodlands at upper ecotones with ponderosa pine forests in Arizona and New Mexico (2008)

Huffman, David W. ; Fulé, Peter Z. ; Pearson, Kristen M. ; [weitere]

Canadian Science Publishing

In: Canadian Journal of Forest Research. 2008; 38(8): 2097-2108. Published 2008 Aug 01. doi: 10.1139/x08-053.

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Publikationsdatum: 2008-08-01

Beschreibung: We used maps of fire evidence, fire scar dendrochronology, forest age-structure analysis, and landscape analysis to investigate fire history at pinyon pine ( Pinus edulis Engelm.) – juniper ( Juniperus osteosperma (Torr.) Little, Juniperus scopulorum Sarg.) woodland – ponderosa pine ( Pinus ponderosa P. & C. Lawson) forest ecotones in Arizona (Tusayan) and in New Mexico (Canjilon). Results showed that charred trees were not evenly distributed across vegetative communities but were significantly (p 〈 0.001) more abundant than expected in ponderosa pine communities. Composite fire scar analysis indicated that surface fires occurred in ponderosa pine stands at both sites and burned at intervals of 7.2–11.1 years (WMPI; Weibull median probability interval). At Tusayan, landscape structure was fine grained, and maximum pinyon age was 〉200 years across 80% of the site. At Canjilon, landscape pattern was relatively coarse, and most pinyon patches were 200–300 years old. Cumulative standing age distributions suggested pinyon–juniper fire rotations of 340 and 290 years at Tusayan and Canjilon, respectively. We concluded the following: (i) surface fires in ponderosa pine stands did not spread through pinyon–juniper communities at either site, (ii) fire evidence was prevalent across both sites, but old pinyon trees indicated that no widespread lethal fires had occurred in the last 300–400 years, and (iii) structurally heterogeneous landscapes suggested that historical pinyon–juniper fires were of limited extent but lethal in patches.

Print ISSN: 0045-5067

Digitale ISSN: 1208-6037

Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft

Publiziert von Canadian Science Publishing

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Status of High latitude precipitation estimates from observations and reanalyses (2016)

Ali Behrangi, Matthew Christensen, Mark Richardson, Matthew Lebsock, Graeme Stephens, George J. Huffman, David Bolvin, Robert F. Adler, Alex Gardner, Bjorn Lambrigtsen, Eric Fetzer

Wiley

In: Journal of Geophysical Research JGR - Atmospheres

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Publikationsdatum: 2016-04-07

Beschreibung: An intercomparison of high-latitude precipitation characteristics from observation-based and reanalysis products is performed. In particular the precipitation products from CloudSat provide an independent assessment to other widely used products, these being the observationally-based GPCP, GPCC and CMAP products and the ERA-Interim, MERRA and NCEP-DOE R2 reanalyses. Seasonal and annual total precipitation in both hemispheres poleward of 55° latitude is considered in all products, and CloudSat is used to assess intensity and frequency of precipitation occurrence by phase, defined as rain, snow or mixed phase. Furthermore, an independent estimate of snow accumulation during the cold season was calculated from the Gravity Recovery and Climate Experiment (GRACE). The intercomparison is performed for the 2007-2010 period when CloudSat was fully operational. It is found that ERA- Interim and MERRA are broadly similar, agreeing more closely with CloudSat over oceans. ERA-Interim also agrees well with CloudSat estimates of snowfall over Antarctica where total snowfall from GPCP and CloudSat is almost identical. A number of disagreements on regional or seasonal scales are identified: CMAP reports much lower ocean precipitation relative to other products, NCEP-DOE R2 reports much higher summer precipitation over northern hemisphere land, GPCP reports much higher snowfall over Eurasia, and CloudSat overestimates precipitation over Greenland, likely due to mischaracterization of rain and mixed-phase precipitation. These outliers are likely unrealistic for these specific regions and time periods. These estimates from observations and reanalyses provide useful insights for diagnostic assessment of precipitation products in high latitudes, quantifying the current uncertainties, improving the products, and establishing a benchmark for assessment of climate models.

Print ISSN: 0148-0227

Thema: Geologie und Paläontologie , Physik