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  • 1
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    Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV (1994)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: The 3-dimensional crystal structure of glutathione S-transferase (GST) of Schistosoma japonicum (Sj) fused with a conserved neutralizing epitope on gp41 (glycoprotein, 41 kDa) of human immunodeficiency virus type 1 (HIV-1) (Muster T et al., 1993, J Virol 67:6642-6647) was determined at 2.5 A resolution. The structure of the 3-3 isozyme rat GST of the mu gene class (Ji X, Zhang P, Armstrong RN, Gilliland GL, 1992, Biochemistry 31:10169-10184) was used as a molecular replacement model. The structure consists of a 4-stranded beta-sheet and 3 alpha-helices in domain 1 and 5 alpha-helices in domain 2. The space group of the Sj GST crystal is P4(3)2(1)2, with unit cell dimensions of a = b = 94.7 A, and c = 58.1 A. The crystal has 1 GST monomer per asymmetric unit, and 2 monomers that form an active dimer are related by crystallographic 2-fold symmetry. In the binding site, the ordered structure of reduced glutathione is observed. The gp41 peptide (Glu-Leu-Asp-Lys-Trp-Ala) fused to the C-terminus of Sj GST forms a loop stabilized by symmetry-related GSTs. The Sj GST structure is compared with previously determined GST structures of mammalian gene classes mu, alpha, and pi. Conserved amino acid residues among the 4 GSTs that are important for hydrophobic and hydrophilic interactions for dimer association and glutathione binding are discussed.
    Keywords: Life Sciences (General)
    Type: Protein science : a publication of the Protein Society (ISSN 0961-8368); Volume 3; 12; 2233-44
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  • 2
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    Preliminary crystallographic studies of four crystal forms of serum albumin (1994)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Several crystal forms of serum albumin suitable for three-dimensional structure determination have been grown. These forms include crystals of recombinant and wild-type human serum albumin, baboon serum albumin, and canine serum albumin. The intrinsic limits of X-ray diffraction for these crystals are in the range 0.28-0.22 nm. Two of the crystal forms produced from human and canine albumin include incorporated long-chain fatty acids. Molecular replacement experiments have been successfully conducted on each crystal form using the previously determined atomic coordinates of human serum albumin illustrating the conserved tertiary structure.
    Keywords: Life Sciences (General)
    Type: European journal of biochemistry / FEBS (ISSN 0014-2956); Volume 226; 3; 1049-52
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  • 3
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    Aircraft modal supression system: Existing design approach and its shortcomings (1989)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: The bending of flexible body aircraft may degrade the ride coMfort of passengers. This is especially noticeable towards the aft end of the aircraft (due to the relatively large tail surfaces) which may easily be excited when flying through turbulence. In addition, some aircraft may experience a front body bending mode which can be annoying to the cabin crew and first class passengers. Normally, this dominant body bending mode falls between 1 to 5 Hz. This range is easily perceived by the human body. Also, in some situations, the rigid body control law may be out of phase with the mode and aggravate the vibration. Hence, an active modal suppression system is desirable for improving the ride quality of the airplane. The size of the mathematical model, which has both the airplane rigid body and flexible characteristics, could easily exceed 100 states. The computational burden and fidelity of this large structural model is addressed.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA. Langley Research Center, Proceedings of the Workshop on Computational Aspects in the Control of Flexible Systems, Part 2; p 801-823
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  • 4
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    Structural stability augmentation system design using BODEDIRECT: A quick and accurate approach (1989)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: A methodology is presented for a modal suppression control law design using flight test data instead of mathematical models to obtain the required gain and phase information about the flexible airplane. This approach is referred to as BODEDIRECT. The purpose of the BODEDIRECT program is to provide a method of analyzing the modal phase relationships measured directly from the airplane. These measurements can be achieved with a frequency sweep at the control surface input while measuring the outputs of interest. The measured Bode-models can be used directly for analysis in the frequency domain, and for control law design. Besides providing a more accurate representation for the system inputs and outputs of interest, this method is quick and relatively inexpensive. To date, the BODEDIRECT program has been tested and verified for computational integrity. Its capabilities include calculation of series, parallel and loop closure connections between Bode-model representations. System PSD, together with gain and phase margins of stability may be calculated for successive loop closures of multi-input/multi-output systems. Current plans include extensive flight testing to obtain a Bode-model representation of a commercial aircraft for design of a structural stability augmentation system.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA. Langley Research Center, Proceedings of the Workshop on Computational Aspects in the Control of Flexible Systems, Part 2; p 825-851
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  • 5
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    Properties and performance of fine-filament bronze-process Nb3Sn conductors (1979)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Fine-filament bronze-process Nb3Sn superconductors were fabricated to fulfill stringent requirements on critical current under tension in a one-inch bend diameter, current density, stability, and conductor losses. A large fraction of niobium filaments was incorporated in a bronze matrix, and a cable containing 4453 2-micron diameter filaments in each of six strands provided a current density of 85,000 A/sq cm at 10 to the -11th ohm-cm, 10 T, and 4.2 K. The next step was to incorporate copper stabilizer in a conductor with 20,538 filaments. These conductors, fabricated so that bend strains of about 1% would be experienced by the filaments in the one-inch bend, stably carried currents in the 200-500 A range. A quench current of 540 A in a 5-cm bend corresponds to 158,000 A/sq cm in the bronze and filament area, believed to be the highest critical current density reported for multifilamentary Nb3Sn.
    Keywords: SOLID-STATE PHYSICS
    Format: text
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  • 6
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    Low cost silicon solar arrays (1975)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Continuous growth methodology for silicon solar cell ribbons deals with capillary effects, die effects, thermal effects and crystal shape effects. Emphasis centers on the shape of the meniscus at the ribbon edge as a factor contributing to ribbon quality with respect to defect densities. Structural and electrical characteristics of edge defined, film-fed grown silicon ribbons are elaborated. Ribbon crystal solar cells produce AMO efficiencies of 6 to 10%.
    Keywords: ENERGY PRODUCTION AND CONVERSION
    Type: Proc. of the 1st ERDA Semiann. Solar Photovoltaic Conversion Program Conf.; p 104-171
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  • 7
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    Air Force/Ion Physics hardened lithium doped solar cell development (1971)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Introduction of lithium by ion implantation eliminates reproducibility and surface problem deficiencies of other introduction techniques. Implantation has been demonstrated to make possible a degree of control over the cell lithium content which has not previously been available. Front barrier development remains to be completed. Successful development of the barrier will make available the freedom to select optimum lithium concentration throughout the cell, including in the vicinity of the junction.
    Keywords: AUXILIARY SYSTEMS
    Type: JPL Proc. of the Fourth Ann. Conf. on Effects of Lithium Doping on Silicon Solar Cells; p 31-34
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  • 8
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    Performance of a commercial transport under typical MLS noise environment (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The performance of a 747-200 automatic flight control system (AFCS) subjected to typical Microwave Landing System (MLS) noise is discussed. The performance is then compared with the results from a previous study which had a B747 AFCS subjected to the MLS standards and recommended practices (SARPS) maximum allowable noise. A glide slope control run with Instrument Landing System (ILS) noise is also conducted. Finally, a linear covariance analysis is presented.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Type: NASA-CR-178032 , NAS 1.26:178032 , D6-57212
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  • 9
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    Fault tolerant control laws (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A systematic procedure for the synthesis of fault tolerant control laws to actuator failure has been presented. Two design methods were used to synthesize fault tolerant controllers: the conventional LQ design method and a direct feedback controller design method SANDY. The latter method is used primarily to streamline the full-state Q feedback design into a practical implementable output feedback controller structure. To achieve robustness to control actuator failure, the redundant surfaces are properly balanced according to their control effectiveness. A simple gain schedule based on the landing gear up/down logic involving only three gains was developed to handle three design flight conditions: Mach .25 and Mach .60 at 5000 ft and Mach .90 at 20,000 ft. The fault tolerant control law developed in this study provides good stability augmentation and performance for the relaxed static stability aircraft. The augmented aircraft responses are found to be invariant to the presence of a failure. Furthermore, single-loop stability margins of +6 dB in gain and +30 deg in phase were achieved along with -40 dB/decade rolloff at high frequency.
    Keywords: QUALITY ASSURANCE AND RELIABILITY
    Type: NASA-CR-178094 , NAS 1.26:178094
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  • 10
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    The SA-2239/WLQ-4(V) Cutty Sark distribution system (1981)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: A redundant frequency and time distribution system provides a multiplicity of isolated outputs, all of which are derived from three atomic frequency standards. The distribution system monitors input parameters of the signals coming from the Cesium Standards and selects one to be the primary standard, phase locks an internal oscillator which has excellent aging characteristics in the open loop mode and acts as a filter to provide phase noise improvement, and generates 1 megahertz and 100 kHz by direct synthesis. Additionally, the system distributes RF and timing signals consisting of 5 MHz, 1 MHz, 100 kHz, BCD Time-of-Day, 1 pps and 1 ppm.
    Keywords: COMMUNICATIONS AND RADAR
    Type: NASA. Goddard Space Flight Center Proc. of the 12th Ann. Precise Time and Time Interval. and Planning; p 765-783
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