ISSN:
1573-4978
Keywords:
proteasomes
;
prosomes
;
proteasomal RNA
;
translation inhibition
;
RNase activity
;
RNase E
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The 20S proteasome (prosome) is a highly organized multi-protein complex with approximate molecular weight of about 700 kDa. Whilst the role of the proteasome in the processing and turnover of cellular proteins is becoming clearer, its relationship with RNA remains obscure. Over the last decade the possibility of association of proteasomes with specific RNAs or mRNPs have been particularly controversial. Proteasomes were reported to inhibit translation of viral mRNAs and to be tightly associated with RNase activity. It is possible that proteasomes are also involved in cellular RNA breakdown and RNA processing like prokaryotic RNase E.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00990969
Permalink