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Relationships between proteasomes and RNA

  • Special Issue: Proteasomes And Related Complexes
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Abstract

The 20S proteasome (prosome) is a highly organized multi-protein complex with approximate molecular weight of about 700 kDa. Whilst the role of the proteasome in the processing and turnover of cellular proteins is becoming clearer, its relationship with RNA remains obscure. Over the last decade the possibility of association of proteasomes with specific RNAs or mRNPs have been particularly controversial. Proteasomes were reported to inhibit translation of viral mRNAs and to be tightly associated with RNase activity. It is possible that proteasomes are also involved in cellular RNA breakdown and RNA processing like prokaryotic RNase E.

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References

  1. Grziwa A, Baumeister W, Dahlmann B & Kopp F (1991) FEBS Lett. 290: 186–190

    Google Scholar 

  2. Achstetter T, Ehmann C, Osaki A & Wolf DH (1984) J. Biol. Chem. 259: 13344–13348

    Google Scholar 

  3. Heinetneyer W, Kleinschmidt JA, Saidowsky J, Escher C & Wolf DH (1991) EMBO J. 10: 555–562

    Google Scholar 

  4. Schmid HP, Akhayat O, Martins de Sa C, Puvion F, Köhler K & Scherrer K (1984) EMBO J. 3: 29–34

    Google Scholar 

  5. Martins de Sa C, Grossi de Sa MF, Akhayat O, Broders F, Scherrer K, Horsch A & Schmid HP (1986) J. Mol. Biol. 187: 479–493

    Google Scholar 

  6. Schliephacke M, Kremp A, Schmid HP, Köhler K & Kull U (1991) Eur. J. Cell. Biol. 55: 114–121

    Google Scholar 

  7. Tanaka K, Tamura T, Yoshimura T, Ichihara A (1992) The new biologist. 4: 173–187

    Google Scholar 

  8. Rivett AJ (1993) Biochem. J. 291: 1–10.

    Google Scholar 

  9. Falkenburg PE, Haass C, Kloetzel PM, Niedel B, Kopp F, Kühn L & Dahlmann B (1988) Nature 331: 190–192

    Google Scholar 

  10. Orlowski M (1993) J. Lab. Clin. Med. 121: 187–189

    Google Scholar 

  11. Wilk S & Orlowski M (1983) J. Neurochem. 40: 842–849

    Google Scholar 

  12. Ortiz-Navarrete V, Seelig A, Gernold M, Frentzel S, Kloetzel PM & Hämmerling GJ (1991) Nature 353: 662–664

    Google Scholar 

  13. Martinez CK & Monaco JJ (1991) Nature 353: 664–668

    Google Scholar 

  14. Palombella V, Rando O, Goldberg AL & Maniatis T (1994) Cell 78: 773–785

    Google Scholar 

  15. Driscoll J & Goldberg AL (1990) J. Biol. Chem. 265: 4789–4792.

    Google Scholar 

  16. Eytan E, Ganoth D, Armon T & Hershko A (1989) Proc. Natl. Acad. Sci. USA 86: 7751–7755

    Google Scholar 

  17. Hough R, Pratt G & Rechsteiner M (1987) J. Biol. Chem. 262: 8303–8313

    Google Scholar 

  18. Peters JM, Cejka Z, Harris JR, Kleinschmidt JA & Baumeister WJ (1993) J. Mol. Biol. 234: 932–937

    Google Scholar 

  19. Pamnani V, Haas B, Pühler G, Sänger HL & Baumeister W (1994) Eur. J. Biochem. 225: 511–519

    Google Scholar 

  20. Pühler G., Weinkauf S., Bachmann L., Müller S., Engel A., Hegerl R & Baumeister W (1992). EMBO J. 11: 1607–1616.

    Google Scholar 

  21. Horsch A, Martins de Sa C, Dineva B, Spindler E & Schmid HP (1989) FEBS Lett. 246: 131–136

    Google Scholar 

  22. Tsukahara T, Tanaka K, Ogawa T, Ishiura S, Fuaabiki R & Sugitka H (1989) FEBS Lett. 255: 179–183

    Google Scholar 

  23. Pouch M-N, Petit F, Buri J, Briand Y & Schmid HP (1994) Submitted for publication

  24. Nothwang HG, Coux O, Bey F & Scherrer K (1992) Eur. J. Biochem. 207: 621–630

    Google Scholar 

  25. Peters JM, Walsh MJ & Franke WW (1990) EMBO J. 9: 1757–1767

    Google Scholar 

  26. Peters JM, Harris JR, Lustig A, Müller S, Engel A, Volker S & Franke WW (1992) J. Mol. Biol. 223: 557–571

    Google Scholar 

  27. Horsch A, Köhler K, Ellwart-Tschürz M & Schmid HP (1990) FEBS Lett. 269: 336–340

    Google Scholar 

  28. Arrigo AP, Darlix JL, Khandjian EW, Simon M & Spahr PF (1985) EMBO J. 4: 399–406

    Google Scholar 

  29. Coux O, Nothwang HG, Scherrer K, Bergsma-Schutter W, Arnberg AC, Timmins PA, Langowski J & Cohen-Addad C (1992) FEBS Lett. 300: 49–55

    Google Scholar 

  30. Nothwang HG, Coux O, Keith G, Silva-Pereira I & Scherrer K (1992) Nucleic. Acids. Res. 20: 1959–1965

    Google Scholar 

  31. Skilton HE, Eperon IC & Rivett AJ (1991) FEBS Lett. 279: 351–355

    Google Scholar 

  32. Tomek W, Buri J Vallon R & Schmid HP (1990) J. Chromatogr. 521: 221–229

    Google Scholar 

  33. Dineva B, Tomek W, Köhler K & Schmid HP (1989) Mol. Biol. Rep. 13: 207–211

    Google Scholar 

  34. Nothwang HG, Coux O, Bey F & Scherrer K (1992) Eur. J. Biochem. 287: 733–739

    Google Scholar 

  35. Gaedik R (1988) PhD thesis, University of Stuttgart, FRG

  36. Castano JG, Ornberg R, Koster JG, Tobian JA & Zasloff M (1986) Cell 46: 377–387

    Google Scholar 

  37. Doria M, Carvana G, Calandra P & Tocchinivalentini GP (1991) Nucleic. Acids. Res. 19: 2315–2320

    Google Scholar 

  38. Homma S, Horsch A, Pouch M-N, Petit F, Briand Y & Schmid HP (1994) Mol. Biol. Rep. 20: 57–61

    Google Scholar 

  39. Horsch A (1988) PhD thesis, University of Stuttgart, FRG

  40. Brawermann G (1987) Cell 48: 5–6

    Google Scholar 

  41. Belasco JG, Beatty JT, Adams GW, Van Gabain A & Cohen SN (1985) Cell 40: 171–181

    Google Scholar 

  42. Burton ZF, Gross CA, Watanabe KK & Burgess RR (1983) Cell 32: 335–349

    Google Scholar 

  43. Majnik V & Godson GN (1993) J. Biol. Chem. 268: 13253–13260

    Google Scholar 

  44. Mudd EA & Higgins CF (1993) Mol. Microbiol. 9: 557–568

    Google Scholar 

  45. Casarégola S, Jacq A, Ladoudj D, McGurk G, Margarson S, Tempête M, Norris V & Holland JB (1992) J. Mol. Biol. 228: 30–40

    Google Scholar 

  46. Sohlberg B, Lundberg U, Hartl F-U & Van Gabain A (1993) Proc. Natl. Acad. Sci. USA 90: 277–281

    Google Scholar 

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Authors and Affiliations

  1. Clermont-Ferrand II, Université Blaise Pascal, 24 Avenue des Landais, 63177, Aubière Cédex, France

    Hans-Peter Schmid, Marie-Noëlle Pouch, Franck Petit, Marie-Helène Dadet, Saloua Badaoui, Gerard Boissonnet & Yves Briand

  2. Station de Virologie et d'Immunologie Moléculaire, INRA, Domaine de Vilvert, 78350, Jouy en Josas, France

    Jacques Buri

  3. Department of Microbiology and Immunology, University of Leicester, LEI 9HN, Leicester, UK

    Vic Norris

Authors
  1. Hans-Peter Schmid
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  2. Marie-Noëlle Pouch
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  3. Franck Petit
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  4. Marie-Helène Dadet
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  5. Saloua Badaoui
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  6. Gerard Boissonnet
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  7. Jacques Buri
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  8. Vic Norris
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  9. Yves Briand
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Schmid, HP., Pouch, MN., Petit, F. et al. Relationships between proteasomes and RNA. Mol Biol Rep 21, 43–47 (1995). https://doi.org/10.1007/BF00990969

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  • DOI: https://doi.org/10.1007/BF00990969

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