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  • cholesterogenesis  (1)
  • hypothyroidism  (1)
  • solid-phase spectrophotometry  (1)
  • Springer  (3)
  • American Chemical Society (ACS)
  • 1990-1994  (3)
Collection
Keywords
Publisher
  • Springer  (3)
  • American Chemical Society (ACS)
Years
  • 1990-1994  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Methimazole treatment reduces cardiac hypertrophy and mortality without a concomitant reduction in blood pressure in established Goldblatt two-kidney one clip hypertension (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 755-758 
    Details
    ISSN: 1420-9071
    Keywords: Goldblatt two-kidney one clip hypertension ; methimazole ; hypothyroidism ; relative cardiac hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of methimazole, and antithyroid drug, on blood pressure and other parameters were evaluated in the established phase of Goldblatt two-kidney one clip (G2K-1C) hypertension. Methimazole was administered via drinking water for five weeks, starting five weeks after hypertension had been induced. After this period of treatment, similarly high blood pressures were observed in methimazole-treated and non-treated G2K-1C rats, despite the fact that a hypothyroid state had been achieved in methimazole-treated rats. Methimazole-treated G2K-1C rats showed reductions in heart rate, ventricular weight, ventricular/body weight ratio and mortality in comparison with rats not treated with methimazole. These results clearly demonstrate that hypothyroidism induced by methimazole: a) does not reverse G2K-1C hypertension, but b) improves the rate of survival and c) reduces relative cardiac hypertrophy, possibly by the reduction in cardiac work observed in Goldblatt hypothyroid rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124296
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of tungsten with pyrocatechol violet by first-derivative solid-phase spectrophotometry (1994)
    Springer
    Microchimica acta 112 (1994), S. 225-235 
    Details
    ISSN: 1436-5073
    Keywords: solid-phase spectrophotometry ; derivative spectrophotometry ; pyrocatechol violet ; tungsten determination ; natural and industrial waters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Derivative spectrophotometry was applied to solid-phase spectrophotometry in order to enhance its sensitivity and remove the large background caused by the absorbance of the resin layer. Determination of micro-amounts of tungsten with pyrocatechol violet to form a 2∶1 green complex in acid medium which is fixed on a dextran-type anion-exchange resin (Sephadex QAEA-25) is described as an example for the application of this technique. The absorbance of the resin packed in a 1-mm spectrophotometric cell, was measured directly. The characteristic peak amplitude of the signal at 674 nm in the first-derivative spectrum is useful for quantitative determination of tungsten (3–16 μg 1−1; RSD 5.8%) in natural and industrial water samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01242838
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis (1991)
    Springer
    Molecular and cellular biochemistry 105 (1991), S. 21-25 
    Details
    ISSN: 1573-4919
    Keywords: cholesterogenesis ; phenylketonuria ; HMG-CoA reductase ; MVAPP decarboxylase ; phenylalanine-derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Phenylalanine, phenylpyruvate and phenylacetate produced a considerable inhibition of chick liver mevalonate 5-pyrophosphate decarboxylase while mevalonate kinase and mevalonate 5-phosphate kinase were not significantly affected. Phenolic derivatives of phenylalanine produced a similar inhibition of decarboxylase activity than that found in the presence of phenyl metabolites. The degree of inhibition was progressive with increasing concentrations of inhibitors (1.25–5.00 mM). Simultaneous supplementation of different metabolites in conditions similar to those in experimental phenylketonuria (0.25 mM each) produced a clear inhibition of liver decarboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. To our knowledge, this is the first report on the in vitro inhibition of both liver regulatory enzymes of cholesterogenesis in phenylketonuria-like conditions. Our results show a lower inhibition of decarboxylase than that of reductase but suggest an important regulatory role of decarboxylase in cholesterol synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230371
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